Evidence-based effects and studies
Detailed analysis of research findings
In 50 middle-aged Thai women, nightly topical serum containing 20% vitamin C (plus vitamin E and raspberry extract) applied to one side of the face for 8 weeks improved skin lightness, elasticity and radiance versus the untreated side and was well tolerated.
In 50 middle-aged Thai women, nightly topical serum containing 20% vitamin C (plus vitamin E and raspberry extract) applied to one side of the face for 8 weeks improved skin lightness, elasticity and radiance versus the untreated side and was well tolerated.
In 50 middle-aged Thai women, nightly topical serum containing 20% vitamin C (plus vitamin E and raspberry extract) applied to one side of the face for 8 weeks improved skin lightness, elasticity and radiance versus the untreated side and was well tolerated.
In 440 adults with iron-deficiency anemia, adding oral vitamin C (200 mg every 8 hours) to standard oral iron did not improve hemoglobin recovery or iron stores compared with iron alone over 8 weeks (equivalence trial).
Ferrous ascorbate raised hemoglobin and cured more children of anemia than colloidal iron over 12 weeks.
In children with iron‑deficiency anemia, ferrous ascorbate produced larger and faster improvements in hemoglobin and other hematologic indices over 3 months compared with iron polymaltose complex.
An intensive dietary program that increased vitamin C intake (among other changes) improved iron intake and produced modest increases in iron stores compared with placebo, while iron supplementation produced larger increases.
In 440 adults with iron-deficiency anemia, adding oral vitamin C (200 mg every 8 hours) to standard oral iron did not improve hemoglobin recovery or iron stores compared with iron alone over 8 weeks (equivalence trial).
In 440 adults with iron-deficiency anemia, adding oral vitamin C (200 mg every 8 hours) to standard oral iron did not improve hemoglobin recovery or iron stores compared with iron alone over 8 weeks (equivalence trial).
16‑week randomized double‑blind trial (90 enrolled, 87 completed) in women: 5 g/day collagen (± HA + vit C) increased dermal density and reduced roughness and wrinkle severity versus placebo.
16‑week randomized double‑blind trial (90 enrolled, 87 completed) in women: 5 g/day collagen (± HA + vit C) increased dermal density and reduced roughness and wrinkle severity versus placebo.
16‑week randomized double‑blind trial (90 enrolled, 87 completed) in women: 5 g/day collagen (± HA + vit C) increased dermal density and reduced roughness and wrinkle severity versus placebo.
In autologous SCT patients, vitamin C supplementation raised serum vitamin C but did not shorten time to neutrophil recovery; transient higher cytotoxic T cells and a lower (non-significant) bacteremia rate were observed.
Randomized double-blind trial of vitamin C (1000 mg/day) vs placebo in young adults with low vitamin C; not a vitamin D study — included here for completeness but does not test vitamin D.
Patients with acute pancreatitis or colorectal cancer had lower serum vitamin C than healthy controls; antioxidant depletion accompanied increased oxidative stress markers.
Five-year randomized supplementation (50 vs 500 mg/day) showing larger increases in serum vitamin C with high-dose without changing dietary intake.
Randomized double-blind trial of vitamin C (1000 mg/day) vs placebo in young adults with low vitamin C; not a vitamin D study — included here for completeness but does not test vitamin D.
Randomized double-blind trial of vitamin C (1000 mg/day) vs placebo in young adults with low vitamin C; not a vitamin D study — included here for completeness but does not test vitamin D.
In 50 male athletes over 3 weeks of strength training, daily hydrolysed collagen (20 g) plus 50 mg vitamin C restored rate of force development (RFD) to baseline by study end versus continued depression in the placebo group and improved some eccentric jump metrics.
In 50 male athletes over 3 weeks of strength training, daily hydrolysed collagen (20 g) plus 50 mg vitamin C restored rate of force development (RFD) to baseline by study end versus continued depression in the placebo group and improved some eccentric jump metrics.
Among 120 stroke patients with dysphagia, vitamin C stimulation improved swallowing, nutrition markers, and immune markers versus routine care.
Among 120 stroke patients with dysphagia, vitamin C stimulation improved swallowing, nutrition markers, and immune markers versus routine care.
Among 120 stroke patients with dysphagia, vitamin C stimulation improved swallowing, nutrition markers, and immune markers versus routine care.
In a multicenter RCT of septic shock patients, adding IV vitamin C (with hydrocortisone and thiamine) did not speed resolution of shock versus hydrocortisone alone.
In a multicenter RCT of septic shock patients, adding IV vitamin C (with hydrocortisone and thiamine) did not speed resolution of shock versus hydrocortisone alone.
Early combined hydrocortisone, high-dose IV vitamin C, and thiamine did not reduce 90-day or 28-day mortality or improve shock reversal in septic shock patients.
One week of 2 g/day vitamin C in healthy young adults reduced inflammatory markers and modestly lowered blood pressure and improved antioxidant enzyme activity under high PM exposure.
In a randomized, double-blind crossover study (n=27) a single 500 mg dose of liposomal vitamin C produced higher plasma and leukocyte vitamin C levels than standard vitamin C or placebo.
In a randomized, double-blind crossover study (n=27) a single 500 mg dose of liposomal vitamin C produced higher plasma and leukocyte vitamin C levels than standard vitamin C or placebo.
In a randomized, double-blind crossover study (n=27) a single 500 mg dose of liposomal vitamin C produced higher plasma and leukocyte vitamin C levels than standard vitamin C or placebo.
In iron-deficient non-anemic girls, iron therapy with or without added vitamin C improved oxidative stress markers; adding vitamin C did not further change TAC or MDA but raised serum vitamin C levels more.
In this pilot RCT of postmenopausal women with insulin resistance (n=42 completers), vitamin C alone or combined with resveratrol reduced oxidative stress markers and increased total antioxidant capacity but did not change insulin resistance.
Vitamin C (1000 mg/day) reduced lipid peroxidation markers and increased some antioxidant enzymes and certain hematological parameters in power plant workers.
In hyperlipidemic patients, 500 mg vitamin C daily for 10 weeks increased blood vitamin C and was associated with reductions in total cholesterol, apo-B, and MDA versus baseline.
Two-week vitamin C+E supplementation increased plasma vitamins and reduced exercise-induced protein oxidation in trained adults.
A 12-week trial of combined antioxidants including vitamin C (100 mg/day) reduced oxidative damage markers and prevented micronucleus increases versus placebo, with effects influenced by folate status.
Daily vitamin C (1000 mg) plus vitamin E (800 IU) for 8 weeks reduced oxidative stress markers and improved pain scores in women with endometriosis versus placebo.
In zinc-deficient hemodialysis patients, three months of zinc supplementation increased serum zinc, improved red blood cell osmotic fragility and reduced lipid peroxidation (MDA), but some side effects occurred with zinc.
Radioiodine therapy increased oxidative stress markers; vitamin C given before therapy reduced some oxidative enzyme responses versus control.
In HNC patients on cisplatin, the control group given vitamins C+E showed increases in SOD and decreases in MDA, but astaxanthin produced larger MDA reductions.
Vitamin A+C given for 1 month produced mixed effects on oxidative-stress markers: some markers improved in HIV-only patients but worsened or did not improve in HIV-TB co-infected patients.
Three months of community yoga lowered oxidative stress (MDA) and improved BMI, waist, systolic BP and fasting glucose but did not change vitamin C levels.
A 4-month high-antioxidant diet (designed to raise vitamins A, C and E) increased plasma and leukocyte vitamin C, boosted antioxidant enzyme activities, and lowered lipid oxidative markers in women with endometriosis.
In this pilot RCT of postmenopausal women with insulin resistance (n=42 completers), vitamin C alone or combined with resveratrol reduced oxidative stress markers and increased total antioxidant capacity but did not change insulin resistance.
Patients given n‑3 PUFA plus antioxidant vitamins (including 1 g/day vitamin C) before and around cardiac surgery showed reduced oxidative stress and inflammation markers in atrial tissue and blood.
In iron-deficient non-anemic girls, iron therapy with or without added vitamin C improved oxidative stress markers; adding vitamin C did not further change TAC or MDA but raised serum vitamin C levels more.
In patients with prior nonmelanoma skin cancer, 60 days of antioxidant supplementation including zinc produced modest reductions in oxidative stress biomarkers (notably 15-F2t-isoprostane) but differences versus placebo were not statistically significant.
In this pilot RCT of postmenopausal women with insulin resistance (n=42 completers), vitamin C alone or combined with resveratrol reduced oxidative stress markers and increased total antioxidant capacity but did not change insulin resistance.
Resistance training with whey increased some antioxidant markers (including vitamin C) and improved some lipid/HDL measures in overweight young men.
In pregnant smokers randomized to 500 mg/day vitamin C (ancillary analyses of an RCT), umbilical vein blood flow measures were restored toward nonsmoker values and placental gene-expression changes associated with vascular development were partially normalized.
In pregnant smokers randomized to 500 mg/day vitamin C (ancillary analyses of an RCT), umbilical vein blood flow measures were restored toward nonsmoker values and placental gene-expression changes associated with vascular development were partially normalized.
In pregnant smokers randomized to 500 mg/day vitamin C (ancillary analyses of an RCT), umbilical vein blood flow measures were restored toward nonsmoker values and placental gene-expression changes associated with vascular development were partially normalized.
In a biomarker sub-study of the LOVIT sepsis trial (n=457 with plasma samples), three inflammatory subtypes were identified and no subtype showed clear benefit from IV vitamin C; treatment did not produce discernible anti-inflammatory effects.
In a biomarker sub-study of the LOVIT sepsis trial (n=457 with plasma samples), three inflammatory subtypes were identified and no subtype showed clear benefit from IV vitamin C; treatment did not produce discernible anti-inflammatory effects.
In a biomarker sub-study of the LOVIT sepsis trial (n=457 with plasma samples), three inflammatory subtypes were identified and no subtype showed clear benefit from IV vitamin C; treatment did not produce discernible anti-inflammatory effects.
In 30 healthy adults, a 1000 mg vitamin C gummy and caplet produced similar blood absorption and were safe; caplet had a higher peak concentration and gummy had a slower time-to-peak.
In 30 healthy adults, a 1000 mg vitamin C gummy and caplet produced similar blood absorption and were safe; caplet had a higher peak concentration and gummy had a slower time-to-peak.
In 30 healthy adults, a 1000 mg vitamin C gummy and caplet produced similar blood absorption and were safe; caplet had a higher peak concentration and gummy had a slower time-to-peak.
In 58 septic shock patients, intravenous vitamin C (high and low dose) increased norepinephrine concentrations and NE‑synthesis enzyme markers and reduced required exogenous norepinephrine dose, but did not significantly improve clinical scores or mortality.
In 58 septic shock patients, intravenous vitamin C (high and low dose) increased norepinephrine concentrations and NE‑synthesis enzyme markers and reduced required exogenous norepinephrine dose, but did not significantly improve clinical scores or mortality.
In 58 septic shock patients, intravenous vitamin C (high and low dose) increased norepinephrine concentrations and NE‑synthesis enzyme markers and reduced required exogenous norepinephrine dose, but did not significantly improve clinical scores or mortality.
In 30 septic shock patients, a single 60 g sodium ascorbate infusion markedly raised plasma ascorbate, increased cumulative urine output, decreased vasopressor requirements and SOFA score over time, but had small-sample safety signals (hypernatremia, possible hemolysis).
In 30 septic shock patients, a single 60 g sodium ascorbate infusion markedly raised plasma ascorbate, increased cumulative urine output, decreased vasopressor requirements and SOFA score over time, but had small-sample safety signals (hypernatremia, possible hemolysis).
In 30 septic shock patients, a single 60 g sodium ascorbate infusion markedly raised plasma ascorbate, increased cumulative urine output, decreased vasopressor requirements and SOFA score over time, but had small-sample safety signals (hypernatremia, possible hemolysis).
In 83 sepsis patients randomized to standard care ± vitamin C, the vitamin C group had lower SOFA scores, reduced inflammatory and myocardial injury markers, and lower combined morbidity/mortality (9.52% vs 29.27%).
In sepsis patients, IV ascorbic acid combined with thiamine and hydrocortisone shortened time on vasopressors but did not change organ-failure scores or mortality.
In 83 sepsis patients randomized to standard care ± vitamin C, the vitamin C group had lower SOFA scores, reduced inflammatory and myocardial injury markers, and lower combined morbidity/mortality (9.52% vs 29.27%).
In 83 sepsis patients randomized to standard care ± vitamin C, the vitamin C group had lower SOFA scores, reduced inflammatory and myocardial injury markers, and lower combined morbidity/mortality (9.52% vs 29.27%).
A 75-person feasibility RCT of IV then oral vitamin C for moderate–severe CAP showed large increases in plasma vitamin C but no statistically significant differences in mortality or clinical endpoints; trends favored faster clinical stability and shorter hospital stay but the study was underpowered.
A 75-person feasibility RCT of IV then oral vitamin C for moderate–severe CAP showed large increases in plasma vitamin C but no statistically significant differences in mortality or clinical endpoints; trends favored faster clinical stability and shorter hospital stay but the study was underpowered.
A 75-person feasibility RCT of IV then oral vitamin C for moderate–severe CAP showed large increases in plasma vitamin C but no statistically significant differences in mortality or clinical endpoints; trends favored faster clinical stability and shorter hospital stay but the study was underpowered.
In this pilot RCT of septic shock patients, high‑dose IV vitamin C raised plasma vitamin C markedly but did not significantly change vasopressor dose or duration, SOFA scores, ICU/hospital mortality or most inflammatory markers; neutrophil counts were higher at 72 h in the vitamin C group.
In 71 patients with vasoplegic shock, IV vitamin C (1.5 g every 6 h) did not significantly reduce duration of vasopressor use or other clinical outcomes compared with placebo.
In 71 patients with vasoplegic shock, IV vitamin C (1.5 g every 6 h) did not significantly reduce duration of vasopressor use or other clinical outcomes compared with placebo.
Early combined hydrocortisone, high-dose IV vitamin C, and thiamine did not reduce 90-day or 28-day mortality or improve shock reversal in septic shock patients.
Early adjunctive high‑dose IV vitamin C in sepsis was associated with lower 28‑day mortality, lower early SOFA score change, and higher procalcitonin clearance versus control.
In septic shock patients, continuous IV vitamin C did not significantly lower 28-day mortality and was associated with higher use of renal replacement therapy.
In ICU patients with sepsis on vasopressors, IV vitamin C increased the risk of death or persistent organ dysfunction at 28 days compared with placebo.
In septic shock patients, adding vitamin C and thiamine to hydrocortisone did not significantly reduce 28-day mortality but shortened shock duration and vasopressor use and reduced some adverse renal and fever outcomes.
In 60 children with septic shock, IV vitamin C plus hydrocortisone and thiamin was feasible to deliver but did not improve organ-dysfunction-free days and showed a numerically higher 28-day mortality.
In a small RCT of sepsis patients, high‑dose IV vitamin C transiently improved early microvascular perfusion (PPV) and reduced a glycocalyx metric in the smallest capillaries, with no change in mortality.
In septic shock patients, continuous IV vitamin C did not significantly lower 28-day mortality and was associated with higher use of renal replacement therapy.
In septic shock patients, continuous IV vitamin C did not significantly lower 28-day mortality and was associated with higher use of renal replacement therapy.
Double-blind RCT comparing PRP alone vs PRP+vitamin C in partial-thickness rotator cuff tears (two injections 3 weeks apart); both groups improved pain and function over 3 months with no significant difference between groups.
A 6-month randomized trial found the product containing undenatured type II collagen (Artneo) improved pain, stiffness, and some MRI signs of synovitis and was not inferior to glucosamine+chondroitin.
Double-blind RCT comparing PRP alone vs PRP+vitamin C in partial-thickness rotator cuff tears (two injections 3 weeks apart); both groups improved pain and function over 3 months with no significant difference between groups.
Double-blind RCT comparing PRP alone vs PRP+vitamin C in partial-thickness rotator cuff tears (two injections 3 weeks apart); both groups improved pain and function over 3 months with no significant difference between groups.
Oral vitamin C 1000 mg daily did not alter symptom resolution or quality-of-life trajectory compared with placebo in mild-to-moderate COVID-19.
High-dose oral vitamin C for 12 months in children with CMT1A was safe but did not meaningfully improve nerve conduction, strength, function, or quality of life.
Oral vitamin C 1000 mg daily did not alter symptom resolution or quality-of-life trajectory compared with placebo in mild-to-moderate COVID-19.
Small preliminary randomized, placebo-controlled trial of topical QR-333 (combination including vitamin D3) reported symptom improvements in diabetic neuropathy but attribution to vitamin D is unclear.
A wound-specific oral supplement containing arginine, vitamin C and zinc was less effective for wound-healing than a standard nutrition supplement in patients with chronic wounds.
Adding vitamin C to chlorhexidine mouthwash for 14 days did not improve plaque, gingival inflammation, or bleeding compared with chlorhexidine alone; staining patterns were similar between CHX formulations.
Adding vitamin C to chlorhexidine mouthwash for 14 days did not improve plaque, gingival inflammation, or bleeding compared with chlorhexidine alone; staining patterns were similar between CHX formulations.
A dentifrice containing an ascorbic acid derivative showed reduced gingival redness and higher salivary antioxidant activity; primary GI outcome was not significant in ITT but improved in per-protocol analysis.
Adding vitamin C to chlorhexidine mouthwash for 14 days did not improve plaque, gingival inflammation, or bleeding compared with chlorhexidine alone; staining patterns were similar between CHX formulations.
Early combined hydrocortisone, high-dose IV vitamin C, and thiamine did not reduce 90-day or 28-day mortality or improve shock reversal in septic shock patients.
Oral vitamin C starting at 14 weeks in women with prior PPROM modestly delayed membrane rupture and delivery and increased birth weight in the current pregnancy.
Oral vitamin C starting at 14 weeks in women with prior PPROM modestly delayed membrane rupture and delivery and increased birth weight in the current pregnancy.
Oral vitamin C starting at 14 weeks in women with prior PPROM modestly delayed membrane rupture and delivery and increased birth weight in the current pregnancy.
Randomized double-blind trial in pregnant women: micronutrient supplement raised maternal vitamin levels, was associated with 10% higher birth weights and fewer low-birth-weight infants; maternal plasma zinc correlated with newborn height.
Open-label randomized trial of hydrocortisone, vitamin C, and thiamine versus standard care in septic shock found no significant reduction in 60-day/hospital mortality or other key clinical outcomes; trial stopped early.
Open-label randomized trial of hydrocortisone, vitamin C, and thiamine versus standard care in septic shock found no significant reduction in 60-day/hospital mortality or other key clinical outcomes; trial stopped early.
Open-label randomized trial of hydrocortisone, vitamin C, and thiamine versus standard care in septic shock found no significant reduction in 60-day/hospital mortality or other key clinical outcomes; trial stopped early.
In adult cardiac-surgery patients, adding thiamine to high‑dose IV vitamin C reduced immediate postoperative myocardial injury markers and early IL‑6 and was associated with fewer arrhythmias and shorter dobutamine use; no differences in LVEF, CRP, lactate, or ICU/hospital stay.
In adult cardiac-surgery patients, adding thiamine to high‑dose IV vitamin C reduced immediate postoperative myocardial injury markers and early IL‑6 and was associated with fewer arrhythmias and shorter dobutamine use; no differences in LVEF, CRP, lactate, or ICU/hospital stay.
In adult cardiac-surgery patients, adding thiamine to high‑dose IV vitamin C reduced immediate postoperative myocardial injury markers and early IL‑6 and was associated with fewer arrhythmias and shorter dobutamine use; no differences in LVEF, CRP, lactate, or ICU/hospital stay.
In adult cardiac-surgery patients, adding thiamine to high‑dose IV vitamin C reduced immediate postoperative myocardial injury markers and early IL‑6 and was associated with fewer arrhythmias and shorter dobutamine use; no differences in LVEF, CRP, lactate, or ICU/hospital stay.
In adult cardiac-surgery patients, adding thiamine to high‑dose IV vitamin C reduced immediate postoperative myocardial injury markers and early IL‑6 and was associated with fewer arrhythmias and shorter dobutamine use; no differences in LVEF, CRP, lactate, or ICU/hospital stay.
In nulliparous pregnant women, combined vitamins C and E (with iron) from mid-pregnancy reduced the rate of preeclampsia compared with iron alone.
In young healthy men, 12 weeks of vitamin C+E+folate reduced systolic blood pressure but showed no other clear cardiovascular changes.
In a long-term (5 year) randomized trial among participants taking vitamin C (50 mg or 500 mg daily), systolic blood pressure increased over time in all groups and high‑dose vitamin C did not reduce blood pressure.
Eating two kiwifruit daily increased vitamin C intake and lowered systolic blood pressure by ~2.7 mmHg over 7 weeks, without changing fasting insulin or other metabolic markers.
Double-blind controlled trial in overweight older men compared 5 weeks of Enzogenol+vitamin C versus vitamin C alone; cognitive response speed improved with Enzogenol+vitamin C while vitamin C alone produced no improvements.
In mildly hypertensive patients, oral vitamin C supplementation lowered systolic and diastolic blood pressure modestly (short‑term), with no durable lipid changes and no extra benefit from higher doses.
Eight-week randomized trial in 72 middle-aged subjects with cardiovascular risk factors: moderate berry consumption improved platelet function, raised HDL, and lowered systolic blood pressure in those with high baseline BP.
Short-term high-dose combination antioxidants including vitamin C lowered systolic blood pressure (significantly in treated hypertensives) and increased circulating antioxidant levels.
Controlled exposure to fine particulates (± ozone) increased diastolic blood pressure and, in one location, impaired endothelial function; high-dose vitamin C (2 g) pretreatment did not prevent the BP rise or endothelial impairment.
In adolescent girls with metabolic syndrome, 6 weeks of DASH recommendations increased vitamin C levels, lowered insulin and prevented rise in diastolic blood pressure versus usual advice.
In young healthy men, 12 weeks of vitamin C+E+folate reduced systolic blood pressure but showed no other clear cardiovascular changes.
In mildly hypertensive patients, oral vitamin C supplementation lowered systolic and diastolic blood pressure modestly (short‑term), with no durable lipid changes and no extra benefit from higher doses.
In nulliparous pregnant women, combined vitamins C and E (with iron) from mid-pregnancy reduced the rate of preeclampsia compared with iron alone.
In a long-term (5 year) randomized trial among participants taking vitamin C (50 mg or 500 mg daily), systolic blood pressure increased over time in all groups and high‑dose vitamin C did not reduce blood pressure.
In mildly hypertensive patients, oral vitamin C supplementation lowered systolic and diastolic blood pressure modestly (short‑term), with no durable lipid changes and no extra benefit from higher doses.
In this pilot RCT of septic shock patients, high‑dose IV vitamin C raised plasma vitamin C markedly but did not significantly change vasopressor dose or duration, SOFA scores, ICU/hospital mortality or most inflammatory markers; neutrophil counts were higher at 72 h in the vitamin C group.
In this pilot RCT of septic shock patients, high‑dose IV vitamin C raised plasma vitamin C markedly but did not significantly change vasopressor dose or duration, SOFA scores, ICU/hospital mortality or most inflammatory markers; neutrophil counts were higher at 72 h in the vitamin C group.
Bayesian reanalysis of a large randomized trial (LOVIT) found allocation to IV vitamin C was associated with a higher probability of harm: increased risk of death or persistent organ dysfunction at 28 days.
Bayesian reanalysis of a large randomized trial (LOVIT) found allocation to IV vitamin C was associated with a higher probability of harm: increased risk of death or persistent organ dysfunction at 28 days.
Local injectable vitamin C depigmentation produced comparable gingival pigmentation index outcomes to surgical depigmentation at 6 months and higher patient satisfaction (VAS); surgical method showed faster initial improvement at 1 month (objective image score), but long‑term results were similar.
Local injectable vitamin C depigmentation produced comparable gingival pigmentation index outcomes to surgical depigmentation at 6 months and higher patient satisfaction (VAS); surgical method showed faster initial improvement at 1 month (objective image score), but long‑term results were similar.
Local injectable vitamin C depigmentation produced comparable gingival pigmentation index outcomes to surgical depigmentation at 6 months and higher patient satisfaction (VAS); surgical method showed faster initial improvement at 1 month (objective image score), but long‑term results were similar.
In this multicenter double‑blind RCT of early IV vitamin C in ED patients with sepsis/septic shock, there was no significant improvement in the primary outcome (average SOFA day 2–5) or most secondary outcomes; a subgroup with baseline SOFA ≥6 showed a lower SOFA (exploratory). Overall no clear clinical benefit.
In this multicenter double‑blind RCT of early IV vitamin C in ED patients with sepsis/septic shock, there was no significant improvement in the primary outcome (average SOFA day 2–5) or most secondary outcomes; a subgroup with baseline SOFA ≥6 showed a lower SOFA (exploratory). Overall no clear clinical benefit.
In this multicenter double‑blind RCT of early IV vitamin C in ED patients with sepsis/septic shock, there was no significant improvement in the primary outcome (average SOFA day 2–5) or most secondary outcomes; a subgroup with baseline SOFA ≥6 showed a lower SOFA (exploratory). Overall no clear clinical benefit.
In stable COPD patients, oral L‑arginine plus liposomal vitamin C for 4 weeks improved patient‑reported outcomes (CRQ total and dyspnea domains) and activity‑of‑daily‑living scores versus placebo; more patients reached MCID. As the intervention combined two agents, attribution to vitamin C alone is uncertain.
In stable COPD patients, oral L‑arginine plus liposomal vitamin C for 4 weeks improved patient‑reported outcomes (CRQ total and dyspnea domains) and activity‑of‑daily‑living scores versus placebo; more patients reached MCID. As the intervention combined two agents, attribution to vitamin C alone is uncertain.
In stable COPD patients, oral L‑arginine plus liposomal vitamin C for 4 weeks improved patient‑reported outcomes (CRQ total and dyspnea domains) and activity‑of‑daily‑living scores versus placebo; more patients reached MCID. As the intervention combined two agents, attribution to vitamin C alone is uncertain.
Giving an oral combination that included vitamin C improved sexual function and urinary symptoms in people with recurrent UTIs over 3 months.
Giving an oral combination that included vitamin C improved sexual function and urinary symptoms in people with recurrent UTIs over 3 months.
Adding vitamins C (100 mg/day) and E to standard care for 8 weeks reduced seizure frequency in drug-resistant children but did not change the oxidative stress marker (MDA) versus placebo.
Adding vitamins C (100 mg/day) and E to standard care for 8 weeks reduced seizure frequency in drug-resistant children but did not change the oxidative stress marker (MDA) versus placebo.
A single 1 g IV dose of vitamin C given after anesthesia reduced early catheter-related bladder discomfort and increased patient satisfaction after bladder tumor resection.
A single 1 g IV dose of vitamin C given after anesthesia reduced early catheter-related bladder discomfort and increased patient satisfaction after bladder tumor resection.
PEG with ascorbic acid and sodium phosphate tablets achieved similar bowel-cleaning quality and detection rates, but patient satisfaction and compliance favored sodium phosphate tablets.
One year of low-dose beta-carotene plus vitamin C did not produce higher clinical remission of oral leukoplakia or reduce long-term cancer risk versus placebo.
One year of low-dose beta-carotene plus vitamin C did not produce higher clinical remission of oral leukoplakia or reduce long-term cancer risk versus placebo.
In trained men over 10 weeks, combined vitamin C and E supplementation appeared to blunt some upper-body strength and hypertrophy gains but also reduced visceral fat gain compared with placebo.
In trained men over 10 weeks, combined vitamin C and E supplementation appeared to blunt some upper-body strength and hypertrophy gains but also reduced visceral fat gain compared with placebo.
In trained men over 10 weeks, combined vitamin C and E supplementation appeared to blunt some upper-body strength and hypertrophy gains but also reduced visceral fat gain compared with placebo.
Daily magnesium (450 mg) for 16 weeks did not improve asthma control outcomes compared with placebo.
Adding up to 1,000 mg/day vitamin C to citalopram for 8 weeks did not improve depression scores or suicidal behavior compared with placebo.
Adding up to 1,000 mg/day vitamin C to citalopram for 8 weeks did not improve depression scores or suicidal behavior compared with placebo.
In healthy older people, oral vitamin C raised blood vitamin levels but did not improve vascular dilation; a Mediterranean-type diet did improve vascular function.
A three‑arm randomized trial (kiwifruit, vitamin C tablet, placebo) in adults with low vitamin C showed that kiwifruit improved mood and well‑being early; vitamin C tablets raised plasma vitamin C to saturation and reduced fatigue in participants with low baseline vitamin C.
Oral 1 g vitamin C increased plasma vitamin C and attenuated exercise-induced oxidative stress markers in type 1 diabetic patients and healthy controls.
Double-blind RCT of blackcurrant juice rich in vitamin C and polyphenols for 6 weeks: raised plasma vitamin C, lowered oxidative stress and improved endothelial function.
In older women doing 6 weeks of moderate training, 1000 mg/day vitamin C raised blood vitamin C but did not produce clear changes in antioxidant balance or inflammatory gene expression.
Two weeks of 500 mg/day oral vitamin C reduced anxiety scores and raised plasma vitamin C compared with placebo in high-school students.
Single 10 g IV vitamin C reduced 'fatigue right now' scores vs placebo at 2 hours and persisted at 24 hours; plasma vitamin C rose markedly and oxidative stress fell.
In 56 healthy smokers randomized to 500 mg vitamin C daily or placebo for 4 weeks, plasma vitamin C increased but markers of lipid peroxidation and pulmonary function tests did not change.
In a 4-week double-blind crossover trial, combined high-dose vitamin C and E lowered urinary albumin excretion in Type 2 diabetic patients.
After 2 years of daily antioxidant supplementation (including 120 mg vitamin C), plasma concentrations of vitamin C, vitamin E, beta-carotene, selenium and zinc were significantly higher than placebo in a 1000-person subsample.
Children given multiple micronutrients including vitamin C had higher plasma antioxidant levels and less oxidized DNA damage in lymphocytes.
Observational study showing higher fruit intake is associated with higher plasma vitamin C concentrations.
In healthy men given endotoxin, high‑dose IV vitamin C restored endothelial-dependent forearm vasodilation that was suppressed by endotoxin.
Eating two SunGold kiwifruit daily (high in vitamin C) for 28 days improved mood, wellbeing, vitality and gut symptoms and raised plasma vitamin C in adults with mild–moderate mood disturbance.
In 21 septic shock patients, 1.5 g IV vitamin C every 6 hours corrected deficiency and produced high plasma concentrations with a short half-life.
In 35 people with type II diabetes, 1.5 g/day oral vitamin C raised plasma levels but did not change oxidative stress marker, blood pressure, or endothelial function after 3 weeks.
In 40 septic shock patients, 3 days of high‑dose IV vitamin C raised blood vitamin C but did not reduce increases in protein oxidative damage.
In this 2-year dietary trial (n=276), plasma vitamin C rose with increased fruit and vegetable intake but tended to plateau above higher intake levels.
Randomized placebo-controlled 2×2 factorial trial in healthy adults testing micronutrient mix (including vitamin C) and bovine colostrum over 10 weeks; micronutrient supplementation raised plasma vitamin C and other micronutrients and enhanced delayed-type hypersensitivity (DTH) responses, especially in older subjects; most other immune parameters unchanged.
In pregnant women with obesity, adding a supplement (includes 90 mg vitamin C plus other nutrients) raised some micronutrients but did not change vitamin C levels or markers of inflammation/oxidative stress.
Irvingia gabonensis kernel extract (300 mg/day) in overweight/obese women for 12 weeks raised plasma vitamin C and maintained adiponectin but did not change fat oxidation, body composition, telomere length, or aerobic capacity.
Pilot randomized trial in 44 critically ill adults found enteral or parenteral alanyl-glutamine did not change plasma vitamin C, glutathione, markers of oxidative stress, lymphocyte subsets, gut permeability, or nitrogen balance compared to control by day 9.
More frequent hemodialysis did not significantly change predialysis plasma vitamin C concentrations or prevalence of deficiency in this small ancillary cohort.
Alpha-tocopherol (vitamin E) supplementation with insulin infusion reduced lipid peroxides and was associated with increased plasma vitamin C concentrations.
Oral vitamin C supplementation markedly and reliably raised plasma vitamin C concentrations in healthy young men.
In healthy volunteers, a 1-month high-heat-treated diet reduced insulin sensitivity and lowered plasma vitamins (including vitamin C) while increasing blood lipids.
In dental students under exam stress, a daily micronutrient supplement including vitamin C modestly raised plasma vitamin C and showed small non-significant improvements in inflammatory and antioxidant markers.
Eating gold kiwifruit daily increased plasma vitamin C and some antioxidants and reduced duration/severity of selected cold symptoms in older adults.
Adults advised to eat more fruit and vegetables for eight weeks had higher plasma vitamin C and carotenoids but no change in lipids.
IV 2 g ascorbic acid given perioperatively did not reduce intraoperative blood loss or change operative outcomes in women undergoing laparoscopic myomectomy.
In a double-blind crossover trial, oral 2 g vitamin C before wave exposure reduced seasickness symptoms and fewer people wanted to leave the raft early; histamine and DAO rose after vitamin C.
In a double-blind crossover trial, oral 2 g vitamin C before wave exposure reduced seasickness symptoms and fewer people wanted to leave the raft early; histamine and DAO rose after vitamin C.
In a double-blind crossover trial, oral 2 g vitamin C before wave exposure reduced seasickness symptoms and fewer people wanted to leave the raft early; histamine and DAO rose after vitamin C.
Five-year randomized trial in older adults with atrophic gastritis found higher-dose (500 mg) vitamin C reduced frequency of multiple colds but did not affect cold duration or severity.
8-week RCT in young men with low-to-marginal vitamin C found supplementation (1000 mg/day) raised plasma vitamin C, reduced the number of participants who reported colds, tended to shorten cold duration and produced modest increases in reported physical activity.
Five-year randomized trial in older adults with atrophic gastritis found higher-dose (500 mg) vitamin C reduced frequency of multiple colds but did not affect cold duration or severity.
Five-year randomized trial in older adults with atrophic gastritis found higher-dose (500 mg) vitamin C reduced frequency of multiple colds but did not affect cold duration or severity.
In a 4-week RCT (500 mg twice daily) in young adults with low vitamin C, supplementation changed gut microbiota (notably reduced Desulfovibrio), reduced markers of endotoxemia/inflammation and correlated with improved mental vitality measures and BDNF increases in responders.
In a 4-week RCT (500 mg twice daily) in young adults with low vitamin C, supplementation changed gut microbiota (notably reduced Desulfovibrio), reduced markers of endotoxemia/inflammation and correlated with improved mental vitality measures and BDNF increases in responders.
In a 4-week RCT (500 mg twice daily) in young adults with low vitamin C, supplementation changed gut microbiota (notably reduced Desulfovibrio), reduced markers of endotoxemia/inflammation and correlated with improved mental vitality measures and BDNF increases in responders.
Randomized controlled trial (three arms, n=15 each) found that adding VitC-loaded I-PRF to non-surgical periodontal therapy did not significantly change bleeding on probing or most long-term clinical/radiographic outcomes versus controls, but it reduced early postoperative pain and showed transient better CAL at 3 months.
In patients receiving non-surgical periodontal therapy, a 4‑week free-sugar avoidance led to greater reductions in bleeding on probing and periodontal inflamed surface area and increased dietary vitamin C intake compared with control.
Randomized controlled trial (three arms, n=15 each) found that adding VitC-loaded I-PRF to non-surgical periodontal therapy did not significantly change bleeding on probing or most long-term clinical/radiographic outcomes versus controls, but it reduced early postoperative pain and showed transient better CAL at 3 months.
Randomized controlled trial (three arms, n=15 each) found that adding VitC-loaded I-PRF to non-surgical periodontal therapy did not significantly change bleeding on probing or most long-term clinical/radiographic outcomes versus controls, but it reduced early postoperative pain and showed transient better CAL at 3 months.
Randomized trial comparing memantine vs vitamin C after elective abdominal surgery; memantine reduced pain more than vitamin C.
A single 2 g oral vitamin C given 1 hour before major abdominal surgery reduced pain scores, lowered morphine use, and decreased need for extra analgesic compared with placebo.
Vitamin C supplementation improved soft‑tissue healing after dental implant surgery in several patient subgroups but did not reduce pain.
Peri- and postoperative vitamin C reduced subjective pain and analgesic use after hip fracture surgery but did not change hip function scores.
8-week RCT in young men with low-to-marginal vitamin C found supplementation (1000 mg/day) raised plasma vitamin C, reduced the number of participants who reported colds, tended to shorten cold duration and produced modest increases in reported physical activity.
8-week RCT in young men with low-to-marginal vitamin C found supplementation (1000 mg/day) raised plasma vitamin C, reduced the number of participants who reported colds, tended to shorten cold duration and produced modest increases in reported physical activity.
Topical multicomponent serum (contains a stabilized form of vitamin C) twice daily reduced melasma severity similar to 4% hydroquinone, improved skin hydration and was better tolerated.
Topical multicomponent serum (contains a stabilized form of vitamin C) twice daily reduced melasma severity similar to 4% hydroquinone, improved skin hydration and was better tolerated.
Topical multicomponent serum (contains a stabilized form of vitamin C) twice daily reduced melasma severity similar to 4% hydroquinone, improved skin hydration and was better tolerated.
Vitamin C delivered by iontophoresis to one side of the face reduced objective pigmentation compared with the control side at 12 weeks.
Yoga and sham-yoga produced similar improvements in many markers in T2DM; only reduced glutathione improved more with yoga, and vitamin C changed within groups but not between groups.
Dietary changes (and mate tea) increased vitamin C intake and were associated with higher antioxidant capacity and glutathione in dyslipidemic subjects.
Multivitamin/mineral supplements given to women undergoing IVF were associated with decreased oxidative stress markers and higher antioxidant vitamin levels in serum and follicular fluid.
Patients given n‑3 PUFA plus antioxidant vitamins (including 1 g/day vitamin C) before and around cardiac surgery showed reduced oxidative stress and inflammation markers in atrial tissue and blood.
Long-term daily vitamin C (500 mg) did not significantly change risk of developing type 2 diabetes in women at high CVD risk over ~9 years (trend to modest reduction).
High-dose IV vitamin C (1.5 g q6h for 5 days) produced some early improvements in oxygenation on day 3 but did not change mortality or discharge SpO2; hospital stay was longer in the vitamin C group.
High-dose IV vitamin C (1.5 g q6h for 5 days) produced some early improvements in oxygenation on day 3 but did not change mortality or discharge SpO2; hospital stay was longer in the vitamin C group.
In septic patients, adding vitamin C (with/without thiamine) did not change mortality but combined vitamin C+thiamine was associated with greater improvement in SOFA score; oxidative stress markers were higher in sepsis than healthy controls.
In term infants with perinatal asphyxia, early intravenous ascorbic acid plus oral ibuprofen did not improve cytokines, mortality, neurologic discharge status, or 6-month developmental outcomes versus placebo.
High-dose IV vitamin C (1.5 g q6h for 5 days) produced some early improvements in oxygenation on day 3 but did not change mortality or discharge SpO2; hospital stay was longer in the vitamin C group.
Randomized, triple‑blind trial of perioperative ascorbic acid vs placebo in CABG patients; monitored postoperative atrial fibrillation and complications.
A double-blind RCT of a micronutrient combination including vitamin D3 modestly improved common cold symptom scores and reduced the decline in 25(OH)D3 vs placebo.
Physically active men who practiced yoga for 3 months had improvements in antioxidant markers (including higher vitamin C) and some metabolic measures versus controls.
Large observational cohort: heavier soup consumers had higher dietary vitamin C intake; serum vitamin C was slightly higher but not significantly.
In critically ill patients, supplementation with vitamins A, C and E reduced lipid peroxidation (MDA) and altered antioxidant vitamin levels but did not change clinical outcomes (ventilation, mortality, length of stay).
Randomized 8-week trial: adding fruit or nuts raised serum vitamin C in both groups; no change in hepatic fat; basal metabolic rate increased in the nut group.
Six months of a multivitamin (including 150 mg vitamin C) prevented the decline in serum vitamin C seen in the placebo group but did not raise vitamin C above baseline.
Four-week multi-antioxidant supplementation (including 1500 mg/day vitamin C) raised serum vitamin levels but did not change markers of oxidative stress, airway inflammation, or allergen-specific immune responses.
Higher blood vitamin C was associated with lower odds of mild dementia in this cross-sectional case-control study of older adults.
Double-blind randomized trial in 106 alcohol-dependent inpatients comparing 21 days of micronutrient supplementation (including zinc 20 mg) versus placebo and measuring serum vitamin and trace element levels.
Obese participants on a 3-month low-calorie, DRI-covering formula diet showed declines in cellular and serum vitamin C but an increase in leukocyte vitamin C; some vitamin C deficiency cases increased after the diet.
Hemodialysis patients given 250 mg vitamin C every other day for 12 weeks had higher blood vitamin C, lower oxidative stress marker, and improved cholesterol/LDL measures.
Six-month double-blind RCT in institutionalized elderly: vitamin supplementation (including vitamin C) increased serum vitamin levels and improved enzymatic antioxidant activity.
In 44 men with moderate-to-severe COPD, an 8-week fortified whey beverage containing 275 mg elemental magnesium improved inflammation, fat-free mass, muscle strength, and respiratory-quality-of-life measures versus control.
In zinc-deficient hemodialysis patients, three months of zinc supplementation increased serum zinc, improved red blood cell osmotic fragility and reduced lipid peroxidation (MDA), but some side effects occurred with zinc.
A single 500 g strawberry beverage (providing ~255 mg vitamin C) rapidly raised serum vitamin C and folate and modestly improved LDL antioxidant capacity without affecting postprandial glucose.
In healthy adults, serum vitamin C concentrations differed by GST genotype and were associated with differences in oxidative stress biomarkers.
High-dose vitamins C+E raised serum vitamin levels but unexpectedly increased markers of haemolysis without improving haemoglobin in sickle cell patients.
Critically ill septic patients receiving an enteral supplement (including vitamin C) had faster improvement in organ dysfunction and serum vitamin C rose to normal range by day 3.
Drinking Concord grape juice daily for 9 weeks increased serum vitamin C, improved antioxidant measures, and increased certain immune cell measures versus placebo.
A 3-week fruit/vegetable concentrate raised blood vitamin C and some antioxidants but did not change markers of oxidative damage in male smokers.
A single 500 g strawberry beverage (providing ~255 mg vitamin C) rapidly raised serum vitamin C and folate and modestly improved LDL antioxidant capacity without affecting postprandial glucose.
A single 500 g strawberry beverage (providing ~255 mg vitamin C) rapidly raised serum vitamin C and folate and modestly improved LDL antioxidant capacity without affecting postprandial glucose.
Vitamin C injections into the gums reduced gum darkening but laser produced faster and larger improvements; pain was higher immediately after injections though satisfaction was similar.
Vitamin C injections into the gums reduced gum darkening but laser produced faster and larger improvements; pain was higher immediately after injections though satisfaction was similar.
Vitamin C injections into the gums reduced gum darkening but laser produced faster and larger improvements; pain was higher immediately after injections though satisfaction was similar.
In septic patients, adding vitamin C (with/without thiamine) did not change mortality but combined vitamin C+thiamine was associated with greater improvement in SOFA score; oxidative stress markers were higher in sepsis than healthy controls.
Daily vitamins E+C for 1 year improved antioxidant biomarkers but did not improve cognitive test scores in elderly with mild cognitive impairment.
In septic patients, adding vitamin C (with/without thiamine) did not change mortality but combined vitamin C+thiamine was associated with greater improvement in SOFA score; oxidative stress markers were higher in sepsis than healthy controls.
Two weeks of 500 mg/day oral vitamin C reduced anxiety scores and raised plasma vitamin C compared with placebo in high-school students.
Two weeks of 500 mg/day oral vitamin C reduced anxiety scores and raised plasma vitamin C compared with placebo in high-school students.
Taking 1 g/day vitamin C for 40 days after knee replacement reduced the risk of complex regional pain syndrome compared with no vitamin C.
Pre-treatment with IV vitamin C prevented the significant drop in serum cortisol seen after etomidate in the control group, suggesting protection against etomidate-induced adrenal suppression.
Single 2 g oral vitamin C given before surgery reduced 24‑hr morphine use after laparoscopic cholecystectomy.
Single 2 g oral vitamin C given before surgery reduced 24‑hr morphine use after laparoscopic cholecystectomy.
Single 2 g oral vitamin C given before surgery reduced 24‑hr morphine use after laparoscopic cholecystectomy.
One week of 2 g/day vitamin C in healthy young adults reduced inflammatory markers and modestly lowered blood pressure and improved antioxidant enzyme activity under high PM exposure.
In people with atrophic gastritis, a higher vitamin C dose raised serum ascorbic acid but did not change CRP or SAA over 5 years.
Oral vitamin C (250 mg thrice weekly for 2 months) restored plasma vitamin C but did not change markers of oxidative stress or inflammation in haemodialysis patients.
Five-day IV antioxidant regimen (including high-dose vitamin C) did not improve early organ dysfunction (SOFA) or AKI overall, but reduced CRP (blunted inflammation) and showed some shorter hospital stay in trauma subgroup.
In hemodialysis patients with refractory anemia, intravenous vitamin C (300 mg each dialysis) improved hemoglobin and iron availability and reduced inflammation markers over 6 months.
Increasing fruit and vegetable intake after surgery reduced CRP more than usual diet, with a correlation between vitamin C intake and CRP reduction.
A multi-component nutraceutical (includes vitamin D among other ingredients) reduced lymphocyte counts, IL-6, and CRP and improved self-reported wellness in hospitalized elderly compared with untreated elderly controls.
In dental students under exam stress, a daily micronutrient supplement including vitamin C modestly raised plasma vitamin C and showed small non-significant improvements in inflammatory and antioxidant markers.
1000 mg/day vitamin C for 2 months lowered CRP among participants with elevated baseline CRP (≥1.0 mg/L).
In septic shock patients, oral vitamin C (small group) restored vitamin C levels and improved organ dysfunction and some inflammation/oxidative markers.
Two-month Mediterranean-style diet (which increased dietary vitamin C intake) showed within-group decreases in some inflammation markers but no significant between-group changes for most adhesion molecules.
A 5-week multi-ingredient supplement (including vitamin C) modestly increased adiponectin and produced subtle omics-signals of reduced inflammation and oxidative stress in overweight men; CRP unchanged.
In 62 CKD patients randomized to three oral iron therapies, the group receiving ferric sodium EDTA combined with vitamin C and other micronutrients showed larger improvements in hemoglobin and iron parameters and reductions in inflammatory markers.
500 mg/day vitamin C for ~2 months did not significantly change urinary 8‑OHdG (a marker of oxidative DNA damage) in nonsmoking adults.
High‑dose IV vitamin C (2 g q6h for 5 days) was associated with improved oxygen saturation, reduced respiratory rate, and less lung involvement on CT versus standard care in this small trial.
High‑dose IV vitamin C (2 g q6h for 5 days) was associated with improved oxygen saturation, reduced respiratory rate, and less lung involvement on CT versus standard care in this small trial.
High‑dose IV vitamin C (2 g q6h for 5 days) was associated with improved oxygen saturation, reduced respiratory rate, and less lung involvement on CT versus standard care in this small trial.
Single 1000 mg oral vitamin C dose in recovering COVID‑19 volunteers produced a transient inhibition of NOX2‑dependent ROS but did not significantly improve mitochondrial or iNOS‑dependent ROS or bioavailable NO compared with PB‑Blend.
Single 1000 mg oral vitamin C dose in recovering COVID‑19 volunteers produced a transient inhibition of NOX2‑dependent ROS but did not significantly improve mitochondrial or iNOS‑dependent ROS or bioavailable NO compared with PB‑Blend.
Single 1000 mg oral vitamin C dose in recovering COVID‑19 volunteers produced a transient inhibition of NOX2‑dependent ROS but did not significantly improve mitochondrial or iNOS‑dependent ROS or bioavailable NO compared with PB‑Blend.
Randomized trial comparing memantine vs vitamin C after elective abdominal surgery; memantine reduced pain more than vitamin C.
Large observational cohort: heavier soup consumers had higher dietary vitamin C intake; serum vitamin C was slightly higher but not significantly.
Daily fruit-and-vegetable puree drinks raised dietary vitamin C and plasma carotenoids and produced a trend toward improved endothelium-dependent vasodilation.
An intensive dietary program that increased vitamin C intake (among other changes) improved iron intake and produced modest increases in iron stores compared with placebo, while iron supplementation produced larger increases.
Five-year randomized supplementation (50 vs 500 mg/day) showing larger increases in serum vitamin C with high-dose without changing dietary intake.
Increasing fruit and vegetable intake raised dietary and biomarker vitamin C levels in adults at increased CVD risk.
A mobile-technology education program (MyPinkMom) for anemic pregnant women increased dietary vitamin C intake substantially and improved hemoglobin versus routine counseling.
In patients receiving non-surgical periodontal therapy, a 4‑week free-sugar avoidance led to greater reductions in bleeding on probing and periodontal inflamed surface area and increased dietary vitamin C intake compared with control.
Large prospective cohort of male smokers found no link between dietary or serum antioxidant vitamins (including vitamin C) and colorectal cancer risk.
6-month randomized weight-loss program (partial meal replacements + exercise) in older obese adults improved diet quality and increased intake of key micronutrients despite reduced calories.
Single 10 g IV vitamin C reduced 'fatigue right now' scores vs placebo at 2 hours and persisted at 24 hours; plasma vitamin C rose markedly and oxidative stress fell.
Single 10 g IV vitamin C reduced 'fatigue right now' scores vs placebo at 2 hours and persisted at 24 hours; plasma vitamin C rose markedly and oxidative stress fell.
Randomized trial in very preterm infants comparing higher vs lower vitamin C intake for 28 days; no significant differences in primary clinical outcomes.
Randomized trial in very preterm infants comparing higher vs lower vitamin C intake for 28 days; no significant differences in primary clinical outcomes.
Randomized placebo-controlled trial in stable COPD patients showing 12 weeks of vitamin C (250 mg/day) improved resistance of WBC DNA to oxidative challenge but did not change lung function.
Randomized placebo-controlled trial in stable COPD patients showing 12 weeks of vitamin C (250 mg/day) improved resistance of WBC DNA to oxidative challenge but did not change lung function.
Pilot randomized trial in septic shock patients showing hydrocortisone plus vitamin C and B1 improved sublingual microcirculation and renal perfusion vs hydrocortisone alone at 24 hours.
Pilot randomized trial in septic shock patients showing hydrocortisone plus vitamin C and B1 improved sublingual microcirculation and renal perfusion vs hydrocortisone alone at 24 hours.
Pilot randomized trial in septic shock patients showing hydrocortisone plus vitamin C and B1 improved sublingual microcirculation and renal perfusion vs hydrocortisone alone at 24 hours.
A fortified drink given 6 days/week for 8 weeks reduced vitamin B12 deficiency prevalence and increased vitamin B12 concentration and hemoglobin in schoolchildren.
Thirty-two hemodialysis patients with functional iron deficiency were randomized to IV ascorbic acid or placebo thrice weekly for 3 months; ferritin declined significantly in the vitamin C group while other labs were unchanged.
Hemodialysis patients receiving 300 mg IV vitamin C each session for 3 months showed improved hemoglobin and transferrin saturation and reduced reticulocyte hemoglobin content and serum ferritin compared with standard care.
Increasing consumption of citrus fruit/juice (rich in vitamin C) after meals improved serum ferritin in iron-depleted preschool children over three months.
Kindergarten children received Sprinkles (contain vitamin C among other micronutrients) daily or weekly for 13 weeks; high consumption and no evidence of iron overload were observed.
In 324 anemic adolescent girls, once- or twice-weekly multiple micronutrient supplements (including vitamin C) improved vitamin C status and several other micronutrients compared with iron+folic acid over 52 weeks; hemoglobin differences were minimal overall.
Daily low-dose MNP containing bioavailable iron and 2.5 mg zinc reduced iron and zinc deficiencies and modestly improved weight-for-age over 23 weeks.
Adding iron plus ascorbic acid to household water increased hemoglobin and ferritin in children and adults over 4 months.
Randomized 16-week trial showing that eating vitamin C–rich gold kiwifruit with iron-fortified cereal improves iron status in women with low iron stores.
A 6-month school feeding intervention with cowpea-based food plus a vitamin C-rich drink increased hemoglobin and reduced anemia prevalence in children.
Fortified porridge given for 6 months raised hemoglobin and ferritin and improved motor development in infants.
244 subjects with atrophic gastritis were randomized to 50 mg or 500 mg vitamin C daily for 5 years; high-dose vitamin C reduced plasma ROS compared with low-dose (between-group p=0.01).
Low-dose enteral vitamin C (500 mg/day) for 14 days increased short-term survival duration in critically ill COVID-19 patients; serum calcium and other electrolytes were unchanged.
Low-dose enteral vitamin C (500 mg/day) for 14 days increased short-term survival duration in critically ill COVID-19 patients; serum calcium and other electrolytes were unchanged.
Low-dose enteral vitamin C (500 mg/day) for 14 days increased short-term survival duration in critically ill COVID-19 patients; serum calcium and other electrolytes were unchanged.
Randomized, double-blind, placebo-controlled trial in 1,444 army recruits given vitamin C 6000 mg/day during 30 days; vitamin C reduced the odds of medically recorded common cold.
Pilot 3-month factorial randomized trial (vitamin C 0, 50, 1000 mg/day) in 54 middle-aged subjects; high-dose vitamin C (1000 mg/day) raised serum ascorbic acid substantially and reached steady state by 1 month.
In smokers, daily 1000 mg vitamin C raised blood vitamin C and produced a large (81%) drop in blood lead after one week; 200 mg had no effect on lead.
In people with atrophic gastritis, a higher vitamin C dose raised serum ascorbic acid but did not change CRP or SAA over 5 years.
Community dietary education increased reported vitamin C intake modestly but produced only minimal change in serum ascorbic acid.
Giving oral antioxidant capsules around ESWL reduced markers of oxidative stress and short-term kidney injury compared with no antioxidants.
In pregnant women with essential hypertension, daily vitamin C+E did not prevent superimposed preeclampsia or small-for-gestational-age infants.
In pregnant women with essential hypertension, daily vitamin C+E did not prevent superimposed preeclampsia or small-for-gestational-age infants.
In pregnant women with essential hypertension, daily vitamin C+E did not prevent superimposed preeclampsia or small-for-gestational-age infants.
Combined vitamin C (1000 mg) and vitamin E did not prevent pre-eclampsia and was associated with a higher rate of low birthweight infants.
Eating two SunGold kiwifruit daily (high in vitamin C) for 28 days improved mood, wellbeing, vitality and gut symptoms and raised plasma vitamin C in adults with mild–moderate mood disturbance.
Eating two SunGold kiwifruit daily (high in vitamin C) for 28 days improved mood, wellbeing, vitality and gut symptoms and raised plasma vitamin C in adults with mild–moderate mood disturbance.
Eight weeks of aerobic exercise improved allergic rhinitis symptoms and nasal airflow; adding 2000 mg/day vitamin C did not show additional benefit given the small sample.
Eight weeks of aerobic exercise improved allergic rhinitis symptoms and nasal airflow; adding 2000 mg/day vitamin C did not show additional benefit given the small sample.
Eight weeks of aerobic exercise improved allergic rhinitis symptoms and nasal airflow; adding 2000 mg/day vitamin C did not show additional benefit given the small sample.
In a large RCT, 12-week quercetin supplementation given with vitamin C and niacin did not change body mass or composition versus placebo.
In a large RCT, 12-week quercetin supplementation given with vitamin C and niacin did not change body mass or composition versus placebo.
In a large RCT, 12-week quercetin supplementation given with vitamin C and niacin did not change body mass or composition versus placebo.
A 10-week mixed flavonoid–fish oil supplement (which included 250 mg vitamin C/day) upregulated antiviral/interferon-related gene expression but did not change standard inflammatory or oxidative-stress biomarkers.
In cyclists, regimens containing vitamin C (with flavonoids ± n-3) attenuated the immediate postexercise rise in F2-isoprostanes (oxidative stress marker) compared with placebo.
Children given multiple micronutrients including vitamin C had higher plasma antioxidant levels and less oxidized DNA damage in lymphocytes.
Long-term micronutrient supplementation (capsules including 250 mg vitamin C plus vitamin E and selenium) was associated with small increases in total and LDL cholesterol after ~7.3 years.
Two small controlled studies in adults ≥70 showed statins lowered LDL but adding antioxidant vitamins (including vitamin C in one arm) did not improve brachial artery flow-mediated or nitroglycerin-mediated vasodilation.
Phlebotomy to reduce iron stores did not change CYP2E1 activity but was associated with lower LDL and vitamin E and a small but significant increase in plasma vitamin C.
In subjects with resistant hypertension and dyslipidemia, 500 mg/day vitamin C for 8 weeks produced no significant improvements in blood pressure, LDL, or endothelial function.
Providing 350 g/day vegetables and using water-free (multi-ply) cookware increased blood vitamin C and reduced oxidized LDL and LDL cholesterol over 2 weeks compared with ordinary cooking or usual diet.
Hemodialysis patients received vitamins; vitamin D3 group had reductions in triglycerides and TG/HDL ratio over 3 months.
In a randomized trial of T2DM patients, combined vitamin C (500 mg) and chromium (200 µg) for the treatment group (n=30) improved glycemic control (HbA1c), lipid profile, liver enzymes and BMI versus placebo.
In 40 older type II diabetic patients, chronic oral vitamin C (1 g/day) improved oxidative markers and reduced insulin and lipid concentrations.
A 3-month trial of a polyphenol-rich antioxidant supplement (pomegranate, green tea extracts, plus ascorbic acid) in type 2 diabetics lowered LDL and MDA and increased antioxidant markers compared with placebo.
In a 75-day randomized double-blind trial, vitamin C (and vitamin E) reduced total and LDL cholesterol and raised HDL in healthy adults aged 50+; vitamin C group showed no significant triglyceride change.
Randomized trial in healthy adults testing aspirin, vitamin C, vitamin E for 4 months; vitamins C/E did not change HbA1c.
In older adults undertaking regular exercise, a multi-ingredient antioxidant beverage (containing vitamin C among others) prevented exercise-induced increases in markers of lipid, protein and DNA oxidation and normalized glutathione and vitamin C levels.
In dialysis patients, high-dose vitamin C infusion (500 mg during dialysis) prevented increases in lipid peroxidation during sessions with a nonmodified membrane, but did not enhance the antioxidant effect of a vitamin E-modified membrane long-term.
A randomized double-blind trial found a single 3 g IV vitamin C dose at induction reduced 0–24 h morphine use, early VAS pain scores, early IL-6 and CRP, and improved early hip flexion after total hip arthroplasty.
Double-blind RCT in 100 THA patients: multi-dose IV vitamin C perioperatively reduced opioid use, lowered pain scores, reduced inflammatory markers, and improved early function.
Double-blind RCT in 100 THA patients: multi-dose IV vitamin C perioperatively reduced opioid use, lowered pain scores, reduced inflammatory markers, and improved early function.
Double-blind RCT in 100 THA patients: multi-dose IV vitamin C perioperatively reduced opioid use, lowered pain scores, reduced inflammatory markers, and improved early function.
Prospective randomized double-blind trial (123 patients) giving oral vitamin C for 45 days after PLIF; pain improved in both groups but vitamin C did not change 1-year postoperative pain versus placebo.
Prospective randomized double-blind trial (123 patients) giving oral vitamin C for 45 days after PLIF; pain improved in both groups but vitamin C did not change 1-year postoperative pain versus placebo.
Prospective randomized double-blind trial (123 patients) giving oral vitamin C for 45 days after PLIF; pain improved in both groups but vitamin C did not change 1-year postoperative pain versus placebo.
In adults with asthma undergoing a corticosteroid-reduction protocol, oral magnesium supplementation (450 mg/day) did not meaningfully reduce the inhaled corticosteroid dose required to maintain control compared with placebo.
Hemodialysis patients received vitamins; vitamin D3 group had reductions in triglycerides and TG/HDL ratio over 3 months.
Daily 100 mg vitamin C from week 20 reduced the incidence of premature rupture of membranes compared with placebo.
Daily oral collagen tripeptide (3 g) improved skin hydration and elasticity and tended to reduce transepidermal water loss over 12 weeks compared with no supplement.
In competitive adolescent swimmers, 1 g/day vitamin C did not change URI incidence overall but shortened duration and reduced severity in males.
In competitive adolescent swimmers, 1 g/day vitamin C did not change URI incidence overall but shortened duration and reduced severity in males.
In competitive adolescent swimmers, 1 g/day vitamin C did not change URI incidence overall but shortened duration and reduced severity in males.
Early adjunctive high‑dose IV vitamin C in sepsis was associated with lower 28‑day mortality, lower early SOFA score change, and higher procalcitonin clearance versus control.
Early adjunctive high‑dose IV vitamin C in sepsis was associated with lower 28‑day mortality, lower early SOFA score change, and higher procalcitonin clearance versus control.
1 g/day vitamin C for 40 days after foot/ankle surgery reduced risk of CRPS.
High-dose vitamin C (>1 g) started at cold onset did not reduce duration or severity of colds in adults.
30 calculus-forming subjects chewed vitamin C gums; vitamin C gum reduced supragingival calculus and bleeding sites; iodine used only as titration reagent in release measurements (study not about iodine effects).
30 calculus-forming subjects chewed vitamin C gums; vitamin C gum reduced supragingival calculus and bleeding sites; iodine used only as titration reagent in release measurements (study not about iodine effects).
Runners given 500 mg/day vitamin C for 15 days had higher plasma vitamin C but vitamin C did not change exercise-induced IL-6 or IL-10 responses.
Daily 1 g vitamin C for 8 weeks reduced inflammatory markers (hs-CRP, IL-6) and fasting blood glucose in hypertensive and/or diabetic obese adults versus control.
Runners given 500 mg/day vitamin C for 15 days had higher plasma vitamin C but vitamin C did not change exercise-induced IL-6 or IL-10 responses.
Runners given 500 mg/day vitamin C for 15 days had higher plasma vitamin C but vitamin C did not change exercise-induced IL-6 or IL-10 responses.
In 91 power-plant workers, 1000 mg/day vitamin C for 3 months reduced several proinflammatory cytokines compared with control.
Supplementation including zinc (with omega-3 and vitamin C) improved asthma control, pulmonary function, and sputum inflammatory markers in children with moderate persistent asthma.
In 56 healthy smokers randomized to 500 mg vitamin C daily or placebo for 4 weeks, plasma vitamin C increased but markers of lipid peroxidation and pulmonary function tests did not change.
Supplementation including zinc (with omega-3 and vitamin C) improved asthma control, pulmonary function, and sputum inflammatory markers in children with moderate persistent asthma.
Supplementation including zinc (with omega-3 and vitamin C) improved asthma control, pulmonary function, and sputum inflammatory markers in children with moderate persistent asthma.
In severe preeclampsia postpartum patients, repeated IV vitamin C did not reduce pulmonary oedema on day 1 but was associated with lower lung ultrasound scores on days 2 and 3.
In severe preeclampsia postpartum patients, repeated IV vitamin C did not reduce pulmonary oedema on day 1 but was associated with lower lung ultrasound scores on days 2 and 3.
In severe preeclampsia postpartum patients, repeated IV vitamin C did not reduce pulmonary oedema on day 1 but was associated with lower lung ultrasound scores on days 2 and 3.
In 149 women undergoing laser-assisted delivery, topical vitamin C applied after resurfacing significantly reduced periorbital skin roughness and wrinkle depth at 3 months; adding growth factors produced larger improvements.
In 149 women undergoing laser-assisted delivery, topical vitamin C applied after resurfacing significantly reduced periorbital skin roughness and wrinkle depth at 3 months; adding growth factors produced larger improvements.
In 149 women undergoing laser-assisted delivery, topical vitamin C applied after resurfacing significantly reduced periorbital skin roughness and wrinkle depth at 3 months; adding growth factors produced larger improvements.
In this pilot RCT of IV 1500 mg vitamin C given before reperfusion, PRS incidence was lower in the vitamin C group (10.5% vs 30%) but not statistically significant; vitamin C raised plasma levels and was associated with higher acute kidney injury and higher re-transplantation in this small sample.
In this pilot RCT of IV 1500 mg vitamin C given before reperfusion, PRS incidence was lower in the vitamin C group (10.5% vs 30%) but not statistically significant; vitamin C raised plasma levels and was associated with higher acute kidney injury and higher re-transplantation in this small sample.
In this pilot RCT of IV 1500 mg vitamin C given before reperfusion, PRS incidence was lower in the vitamin C group (10.5% vs 30%) but not statistically significant; vitamin C raised plasma levels and was associated with higher acute kidney injury and higher re-transplantation in this small sample.
Adding oral vitamin C to atypical antipsychotics for 8 weeks reduced oxidative stress markers and improved psychiatric rating scores in schizophrenia patients.
Vitamin C raised blood vitamin C levels but did not prevent oxidative or immune changes during/after an ultramarathon.
In hepatitis C patients receiving interferon and ribavirin, vitamins E+C kept a fatty acid (EPA) level stable and raised blood vitamin levels.
Four-week antioxidant regimens including ascorbic acid increased plasma ascorbic acid but did not change measures of mononuclear leukocyte DNA damage in smokers or nonsmokers.
A 4-week blueberry/apple juice (providing 16 mg ascorbic acid/day) raised plasma antioxidants and reduced some oxidative DNA damage but increased another DNA adduct type; effects varied by genotype.
An antioxidant-rich (vitamin C–containing) diet after acute MI increased plasma vitamin C and reduced lipid peroxidation and cardiac enzyme rise versus control diet.
Giving 25 mg vitamin C twice daily as limeade raised plasma vitamin C but did not improve hemoglobin or other iron status markers in iron‑deficient women consuming high‑phytate diets.
Three-month moderate-dose vitamin supplementation (including 272 mg vitamin C) repleted plasma ascorbic acid in smokers and raised plasma vitamin E markers.
Individualized nutrition support in malnourished hospital patients improved energy/protein intake, maintained weight, raised vitamin C levels, and reduced complications and readmissions.
Vitamin C (with vitamin E) doubled plasma ascorbic acid and increased mucosal ascorbic acid but did not reduce mucosal reactive oxygen species or malondialdehyde associated with H. pylori infection.
In a double‑blind crossover study, vitamin C supplementation raised plasma ascorbic acid and increased lipid‑standardized alpha‑tocopherol and antioxidant capacity (FRAP), indicating in vivo interactions between vitamins C and E.
Six months of combined high-dose vitamins C and E raised plasma antioxidant levels but did not improve coronary or brachial endothelial function in CAD patients.
Vitamin C raised blood vitamin C levels but did not prevent oxidative or immune changes during/after an ultramarathon.
Vitamin C raised blood vitamin C levels but did not prevent oxidative or immune changes during/after an ultramarathon.
Six months of a probiotic plus 50 mg vitamin C reduced coughing, school absenteeism and antibiotic use in children.
Six months of a probiotic plus 50 mg vitamin C reduced coughing, school absenteeism and antibiotic use in children.
Six months of a probiotic plus 50 mg vitamin C reduced coughing, school absenteeism and antibiotic use in children.
Perioperative IV vitamin C (2 g total) reduced intraoperative hemorrhage volume during abdominal hysterectomy.
Oral vitamin C increased plasma and urinary ascorbate in a dose-dependent manner; nasal lavage (RTLF) ascorbate showed an acute rise after a high (1000 mg) dose peaking at 2–4 h but returned to baseline by 24 h.
In a 4-week crossover trial of 500 mg/day vitamin C in healthy smokers, plasma ascorbate rose but markers of oxidation and endothelial activation did not change.
In 40 gout patients, 500 mg/day vitamin C for 8 weeks raised plasma ascorbate but produced only a very small and clinically insignificant decrease in serum urate compared with allopurinol.
Randomized dietary intervention (0.5 vs 2 kiwifruit/day) in healthy young men showing plasma and skeletal muscle ascorbate increase after 6 weeks; muscle ascorbate rose ≈3.5‑fold and correlated with plasma levels.
Half a kiwifruit or a 50 mg vitamin C tablet daily similarly increased plasma, leukocyte and muscle vitamin C with no difference between sources.
Daily moderate antioxidant supplementation (including 272 mg vitamin C) raised plasma ascorbate but did not change measured markers of lipid or protein oxidative damage in healthy men.
Half a kiwifruit or a 50 mg vitamin C tablet daily similarly increased plasma, leukocyte and muscle vitamin C with no difference between sources.
Half a kiwifruit or a 50 mg vitamin C tablet daily similarly increased plasma, leukocyte and muscle vitamin C with no difference between sources.
Randomized dietary intervention (0.5 vs 2 kiwifruit/day) in healthy young men showing plasma and skeletal muscle ascorbate increase after 6 weeks; muscle ascorbate rose ≈3.5‑fold and correlated with plasma levels.
In vitamin C–deficient individuals, 1 g/day vitamin C for 30 days lowered oxidative stress and improved VO2max and muscle peak torque in most participants.
In vitamin C–deficient individuals, 1 g/day vitamin C for 30 days lowered oxidative stress and improved VO2max and muscle peak torque in most participants.
In vitamin C–deficient individuals, 1 g/day vitamin C for 30 days lowered oxidative stress and improved VO2max and muscle peak torque in most participants.
A multi-component nutraceutical (includes vitamin D among other ingredients) reduced lymphocyte counts, IL-6, and CRP and improved self-reported wellness in hospitalized elderly compared with untreated elderly controls.
One week of 2 g/day vitamin C in healthy young adults reduced inflammatory markers and modestly lowered blood pressure and improved antioxidant enzyme activity under high PM exposure.
In 91 power-plant workers, 1000 mg/day vitamin C for 3 months reduced several proinflammatory cytokines compared with control.
A 4-week polyphenol beverage that contained vitamin C did not improve vascular function but was associated with an increase in IL-6 compared with placebo.
In a 6-week RCT in treated hypertensive adults, vitamin C alone did not change BP variability versus placebo; the high-dose vitamin C + polyphenols combination increased some measures of BP variability.
In a 6-week RCT in treated hypertensive adults, vitamin C alone did not change BP variability versus placebo; the high-dose vitamin C + polyphenols combination increased some measures of BP variability.
In a 6-week RCT in treated hypertensive adults, vitamin C alone did not change BP variability versus placebo; the high-dose vitamin C + polyphenols combination increased some measures of BP variability.
In a randomized, double-blind, crossover study of 25 hyperlipidaemic volunteers, a FoodState Vitamin C complex reduced markers of coagulation activation and increased fibrin network compaction versus placebo.
In a randomized, double-blind, crossover study of 25 hyperlipidaemic volunteers, a FoodState Vitamin C complex reduced markers of coagulation activation and increased fibrin network compaction versus placebo.
In a randomized, double-blind, crossover study of 25 hyperlipidaemic volunteers, a FoodState Vitamin C complex reduced markers of coagulation activation and increased fibrin network compaction versus placebo.
A three‑arm randomized trial (kiwifruit, vitamin C tablet, placebo) in adults with low vitamin C showed that kiwifruit improved mood and well‑being early; vitamin C tablets raised plasma vitamin C to saturation and reduced fatigue in participants with low baseline vitamin C.
A three‑arm randomized trial (kiwifruit, vitamin C tablet, placebo) in adults with low vitamin C showed that kiwifruit improved mood and well‑being early; vitamin C tablets raised plasma vitamin C to saturation and reduced fatigue in participants with low baseline vitamin C.
In a 4‑week randomized, double‑blind placebo‑controlled trial in Fontan patients, vitamin C did not change endothelial function or exercise capacity overall but normalized vascular function more often in those with baseline abnormal vascular function.
In a 4‑week randomized, double‑blind placebo‑controlled trial in Fontan patients, vitamin C did not change endothelial function or exercise capacity overall but normalized vascular function more often in those with baseline abnormal vascular function.
In a 6‑week randomized study of type 2 diabetic patients, 1000 mg/day vitamin C reduced fasting and postprandial oxidative stress (MDA) but did not change lipid profiles.
In a 6‑week randomized study of type 2 diabetic patients, 1000 mg/day vitamin C reduced fasting and postprandial oxidative stress (MDA) but did not change lipid profiles.
ESRD patients randomized to 1,000 mg/day vitamin C showed no significant differences versus placebo on lipid profile or lipoprotein oxidation after one year.
Vitamin C 500 mg/day for 4 weeks increased brachial flow-mediated dilation but did not change lipids or inflammatory markers.
In a 6‑week randomized study of type 2 diabetic patients, 1000 mg/day vitamin C reduced fasting and postprandial oxidative stress (MDA) but did not change lipid profiles.
Giving 2 g IV vitamin C during myomectomy reduced bleeding, shortened operations, and shortened hospital stay.
Giving 2 g IV vitamin C during myomectomy reduced bleeding, shortened operations, and shortened hospital stay.
Giving 2 g IV vitamin C during myomectomy reduced bleeding, shortened operations, and shortened hospital stay.
Ten-week zinc- and micronutrient-rich food or ayurvedic zinc supplements increased plasma zinc and reduced zinc deficiency prevalence in adolescent girls.
Giving low consumers ~480 g/day fruit/veg + up to 300 ml juice for 12 weeks raised blood vitamin C and other nutrients but did not change measures of plasma antioxidant capacity or vascular risk markers.
A perioperative antioxidant-containing drink raised plasma vitamin C and total antioxidant capacity shortly after surgery but did not reduce markers of systemic inflammation.
In 32 diabetic patients with low plasma vitamin C, high-dose oral vitamin C partially restored vitamin C levels but did not improve endothelial function or measures of insulin resistance.
In patients with type 2 diabetes, a calorie-restricted vegetarian diet (± exercise) improved insulin sensitivity, reduced visceral fat, and increased plasma vitamin C versus a conventional diet.
Two-week vitamin C+E supplementation increased plasma vitamins and reduced exercise-induced protein oxidation in trained adults.
Children with chronic constipation had lower antioxidant enzyme activities and lower plasma vitamin C and E compared with matched healthy children.
Chlorella supplementation increased plasma vitamin C and other antioxidant markers and improved erythrocyte antioxidant enzymes in smokers, though DNA damage also decreased with placebo.
IV vitamin C raised plasma levels and substantially reduced spontaneous pain in patients with postherpetic neuralgia but did not affect brush-evoked pain.
In low-income adults, fruit-and-vegetable vouchers increased short-term consumption but did not change blood vitamin C levels at 3 months.
In surgical patients on TPN, plasma vitamin C and other non-supplemented antioxidants fell during TPN despite alpha-tocopherol supplementation normalizing tocopherol levels in one group.
A 12-week water-soluble vitamin supplement improved some vitamin biomarkers, increased weight, and lowered homocysteine in elderly female residents; plasma vitamin C rose in both groups.
In adolescent girls with metabolic syndrome, 6 weeks of DASH recommendations increased vitamin C levels, lowered insulin and prevented rise in diastolic blood pressure versus usual advice.
In septic shock patients, IV antioxidant therapy including vitamin C raised vitamin C levels and improved some hemodynamic measures.
An 8-week double-blind RCT of a multivitamin/multimineral/phytonutrient product increased vitamin C and folate status and reduced homocysteine in adults with low fruit/veg intake.
Grapefruit intake for 2 weeks increased blood vitamin C and reduced gum bleeding in periodontitis patients.
In 122 premenopausal women, a high fruit-and-vegetable dietary intervention significantly increased plasma vitamin C and other carotenoids over one year.
Cross‑sectional study found vegetarians had higher plasma antioxidant status and higher plasma vitamin C (statistically significant) and lower LDL TBARS compared with nonvegetarians.
One tablet daily containing iron plus vitamin C for four weeks raised hemoglobin, hematocrit, serum iron, and vitamin C without increasing plasma oxalate in dialysis patients.
Combined vitamin C (1000 mg) and vitamin E supplementation for 4 weeks raised plasma antioxidant levels and reduced multiple oxidative stress markers in Crohn's disease patients.
12-week double-blind RCT of an MVM (including vitamin D) increased vitamin C and zinc levels and reduced reported illness duration/severity, but did not change 25(OH) vitamin D or measured neutrophil functional assays.
Smokers had smaller, more superficial punch wounds and lower vitamin C and PINP (a collagen synthesis marker); smoking cessation increased wound depth, vitamin C, and PINP; nicotine patch had no detectable effect.
A fruit/vegetable purée drink acutely raised plasma vitamin C and plasma antioxidant capacity and showed a trend toward improved endothelium-dependent vasodilation.
Patients with IgA nephropathy had more oxidative damage and lower antioxidant levels including vitamin C than healthy volunteers.
Isoflavone supplementation reduced homocysteine and some resting oxidative markers but did not change plasma vitamin C or prevent exercise-induced oxidative stress.
Double-blind RCT of a multivitamin/mineral vs placebo in older adults on certain medications; MVMS increased folate and vitamin C status but did not significantly change serum calcium.
A mobile intervention or providing fruits/vegetables increased daily intake (~+0.9 servings/day) and raised plasma vitamin C compared to control in young adults.
Adding guava to a supplemental meal increased vitamin C and improved iron status in preschoolers; the study measured B12 but did not report a B12 effect.
In institutionalized elderly, daily vitamin supplementation (including 120 mg vitamin C) raised plasma vitamin levels (including vitamin C) and some antioxidant enzyme activity over 6–12 months, with limited effects on most immune markers.
In very elderly institutionalized participants, a multivitamin beverage plus exercise raised some antioxidant carotenoids but vitamin C levels were not reported to increase.
In a long-term randomized trial subset, daily multivitamin/mineral (Centrum) increased plasma vitamin B12, folate, vitamin E and improved some other nutrient statuses versus placebo.
In a 4-week randomized study, adding mandarin juice (rich in vitamin C and other antioxidants) to a low-calorie diet in obese children reduced oxidative stress markers and greatly increased plasma vitamin C.
In RA patients, shifting to a Mediterranean diet increased reported vitamin C intake but plasma vitamin C levels were unchanged at 12 weeks; baseline vitamin C correlated inversely with inflammation markers.
A randomized dietary trial showed the Mediterranean-type diet group had fewer deaths and cancers over 4 years; plasma vitamin C levels increased in the diet group, but the effect cannot be attributed solely to vitamin C.
Crossover RCT increasing potassium intake from fruit/veg or supplements in early hypertensives; plasma vitamin C was measured and remained unchanged and blood pressure did not improve.
Randomized cross-over trial in hemodialysis patients with low vitamin C showed that 200 mg/day oral vitamin C raised plasma vitamin C and reduced hs-CRP; some nutritional markers trended upward.
Combined antioxidant therapy including vitamin C (1,000 mg/day) given after suspected MI was associated with smaller mean infarct size and reduced oxidative markers and cardiac events versus placebo, but vitamins were given as a combination so effects cannot be attributed to vitamin C alone.
Patients with chronic bacterial prostatitis had lower plasma vitamin C and antioxidant enzymes and higher oxidative-damage markers than healthy controls.
In healthy middle-aged adults, 7-week supplementation with fruit/vegetable concentrates raised blood levels of several antioxidants including vitamin C.
Two-week antioxidant supplementation (vitamin C + E or fruit/veg powder) reduced some exercise-induced oxidative stress markers in men and women.
Obese participants on a 3-month low-calorie, DRI-covering formula diet showed declines in cellular and serum vitamin C but an increase in leukocyte vitamin C; some vitamin C deficiency cases increased after the diet.
In hypertensive men, 8 weeks of vitamins C (1 g/day) + E increased erythrocyte (Na,K)-ATPase activity, improved oxidative stress markers and reduced blood pressure versus placebo.
Combined vitamin C (1000 mg) and vitamin E supplementation for 4 weeks raised plasma antioxidant levels and reduced multiple oxidative stress markers in Crohn's disease patients.
Intravenous antioxidant therapy (including vitamin C) raised antioxidant levels and lowered oxidative stress markers but did not reduce organ dysfunction at 7 days in severe acute pancreatitis.
Oral vitamin C (250 mg thrice weekly for 2 months) restored plasma vitamin C but did not change markers of oxidative stress or inflammation in haemodialysis patients.
Vitamin C 50 mg/day in premature infants increased plasma vitamin C but did not increase hemolysis markers, bilirubin, or other morbidities versus placebo.
A twice-daily enriched drink increased plasma antioxidant levels including vitamin C in frail elderly people over six months.
In older adults undertaking regular exercise, a multi-ingredient antioxidant beverage (containing vitamin C among others) prevented exercise-induced increases in markers of lipid, protein and DNA oxidation and normalized glutathione and vitamin C levels.
Oral vitamin C (250 mg thrice weekly for 2 months) restored plasma vitamin C but did not change markers of oxidative stress or inflammation in haemodialysis patients.
Vitamin C 500 mg/day modestly lowered daytime systolic blood pressure and increased HDL in women, with no change in clinic BP or LDL.
Vitamin C 500 mg/day modestly lowered daytime systolic blood pressure and increased HDL in women, with no change in clinic BP or LDL.
Vitamin C 500 mg/day modestly lowered daytime systolic blood pressure and increased HDL in women, with no change in clinic BP or LDL.
Iron-containing micronutrient supplements that included vitamin C improved hemoglobin and increased ferritin (iron stores); weekly 60 mg iron regimen was effective and better tolerated.
Adding iron plus ascorbic acid to household water increased hemoglobin and ferritin in children and adults over 4 months.
Six months of providing drinking-water with ascorbic acid (with or without iron) in daycare centers reduced anemia prevalence and increased mean hemoglobin and height gain in preschool children.
In 606 schoolchildren with group A strep infection, adding antioxidant vitamins to penicillin was associated with an increase in hemoglobin compared with penicillin alone.
Daily guava juice (≈200 mg ascorbic acid) given with a meal modestly increased hemoglobin and had a smaller, non-significant increase in ferritin in mildly anemic children.
Higher intake of vitamin C–rich fruits and vegetables was associated with slightly higher hemoglobin in the whole sample and higher ferritin in premenopausal women.
In 62 CKD patients randomized to three oral iron therapies, the group receiving ferric sodium EDTA combined with vitamin C and other micronutrients showed larger improvements in hemoglobin and iron parameters and reductions in inflammatory markers.
Intravenous vitamin C (500 mg thrice weekly) increased hemoglobin, raised transferrin saturation, and lowered the EPO/hemoglobin ratio in hemodialysis patients.
Adding guava to a supplemental meal increased vitamin C and improved iron status in preschoolers; the study measured B12 but did not report a B12 effect.
Preschool children consumed milk fortified with multiple micronutrients (including vitamin C) for 1 year; fortified milk improved growth and iron status and reduced anemia.
Two months of multi-micronutrient Sprinkles (including vitamin C) reduced anemia and increased hemoglobin in 9–24 month old children.
Intravenous vitamin C (500 mg thrice weekly) increased hemoglobin, raised transferrin saturation, and lowered the EPO/hemoglobin ratio in hemodialysis patients.
Intravenous vitamin C (500 mg thrice weekly) increased hemoglobin, raised transferrin saturation, and lowered the EPO/hemoglobin ratio in hemodialysis patients.
Hemodialysis patients receiving 300 mg IV vitamin C each session for 3 months showed improved hemoglobin and transferrin saturation and reduced reticulocyte hemoglobin content and serum ferritin compared with standard care.
IV vitamin C given to iron-overloaded hemodialysis patients improved hematologic markers and reduced erythropoietin requirements.
IV ascorbic acid improved haematocrit and iron availability and reduced erythropoietin dose in iron‑overloaded hemodialysis patients.
In zinc-deficient hemodialysis patients, three months of zinc supplementation increased serum zinc, improved red blood cell osmotic fragility and reduced lipid peroxidation (MDA), but some side effects occurred with zinc.
Intravenous vitamin C (1.5 g every 12 h, 8 doses) in post-cardiac arrest patients did not significantly lower NSE (primary outcome) but was associated with some improved inflammatory and clinical parameters (e.g., lower max PCT, shorter ventilation and ICU stay).
Intravenous vitamin C (1.5 g every 12 h, 8 doses) in post-cardiac arrest patients did not significantly lower NSE (primary outcome) but was associated with some improved inflammatory and clinical parameters (e.g., lower max PCT, shorter ventilation and ICU stay).
Intravenous vitamin C (1.5 g every 12 h, 8 doses) in post-cardiac arrest patients did not significantly lower NSE (primary outcome) but was associated with some improved inflammatory and clinical parameters (e.g., lower max PCT, shorter ventilation and ICU stay).
An 8-month randomized double-blind placebo-controlled trial (n=138 completers) found no overall effect of 1 g/day vitamin C on HDL, LDL, total cholesterol or triglycerides; a small subgroup (n=43, low baseline AA) showed HDL +0.10 mmol/L.
Hemodialysis patients received vitamins; vitamin D3 group had reductions in triglycerides and TG/HDL ratio over 3 months.
In a 75-day randomized double-blind trial, vitamin C (and vitamin E) reduced total and LDL cholesterol and raised HDL in healthy adults aged 50+; vitamin C group showed no significant triglyceride change.
In this large randomized trial of combined atorvastatin plus vitamin C and E vs placebo, treatment did not alter progression of coronary calcification; possible non-significant reduction in ASCVD events was observed.
Adding vitamin C to simvastatin did not provide lipid-profile benefits beyond simvastatin alone in patients with low HDL-C.
Long-term micronutrient supplementation (capsules including 250 mg vitamin C plus vitamin E and selenium) was associated with small increases in total and LDL cholesterol after ~7.3 years.
In a subset of PAD patients, antioxidant vitamin therapy was associated with a small increase in von Willebrand factor.
Secondary analysis of an RCT in type-1 diabetic pregnant women; vitamins C+E did not prevent pre-eclampsia across haptoglobin phenotypes.
Daily 1000 mg vitamin C from mid-pregnancy until delivery did not significantly reduce pre-eclampsia or major neonatal adverse outcomes.
Large randomized trial in pregnant women with type 1 diabetes: vitamins C+E increased blood vitamin levels but did not reduce pre-eclampsia or gestational hypertension overall.
Combined vitamin C (1000 mg) and vitamin E did not prevent pre-eclampsia and was associated with a higher rate of low birthweight infants.
Daily vitamins C and E in high-risk pregnant women did not reduce pre-eclampsia or improve maternal/perinatal outcomes.
Combined vitamin C (1000 mg) and vitamin E did not prevent pre-eclampsia and was associated with a higher rate of low birthweight infants.
Patients given n‑3 PUFA plus antioxidant vitamins (including 1 g/day vitamin C) before and around cardiac surgery showed reduced oxidative stress and inflammation markers in atrial tissue and blood.
A fully remote randomized trial where all participants received vitamin C; no clear benefit of added probiotic over vitamin C alone and good detectability of vitamin C in urine tests.
A fully remote randomized trial where all participants received vitamin C; no clear benefit of added probiotic over vitamin C alone and good detectability of vitamin C in urine tests.
Giving vitamins C and E after PPROM was associated with a longer time from membrane rupture to delivery.
Maternal vitamins C+E after PPROM were associated with a longer time to delivery and slightly later gestational age at birth without increased maternal or neonatal harms.
Maternal vitamins C+E after PPROM were associated with a longer time to delivery and slightly later gestational age at birth without increased maternal or neonatal harms.
High‑dose antenatal vitamins C+E did not improve infant respiratory outcomes and were associated with increased healthcare visits and costs.
High‑dose antenatal vitamins C+E did not improve infant respiratory outcomes and were associated with increased healthcare visits and costs.
A 4-week polyphenol beverage that contained vitamin C did not improve vascular function but was associated with an increase in IL-6 compared with placebo.
In healthy young adults a single antioxidant cocktail (including vitamin C) taken before a high-sodium meal did not change endothelial function or arterial stiffness compared with placebo.
A fortified drink given 6 days/week for 8 weeks reduced vitamin B12 deficiency prevalence and increased vitamin B12 concentration and hemoglobin in schoolchildren.
More frequent hemodialysis did not significantly change predialysis plasma vitamin C concentrations or prevalence of deficiency in this small ancillary cohort.
Radioiodine therapy increased oxidative stress markers; vitamin C given before therapy reduced some oxidative enzyme responses versus control.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
In people with atrophic gastritis, a higher vitamin C dose raised serum ascorbic acid but did not change CRP or SAA over 5 years.
Pregnant smokers given 500 mg/day vitamin C had infants with improved certain measures of airway function at 3 months (two secondary FEF measures), though the primary FEF75 was not significantly changed.
Pregnant smokers given 500 mg/day vitamin C had infants with improved certain measures of airway function at 3 months (two secondary FEF measures), though the primary FEF75 was not significantly changed.
Pregnant smokers given 500 mg/day vitamin C had infants with improved certain measures of airway function at 3 months (two secondary FEF measures), though the primary FEF75 was not significantly changed.
In pregnant women with type 1 diabetes, maternal vitamin C/E supplementation did not increase placental or cord vitamin levels nor change placental antioxidant enzyme activity or lipid peroxidation versus placebo.
In pregnant women with type 1 diabetes, maternal vitamin C/E supplementation did not increase placental or cord vitamin levels nor change placental antioxidant enzyme activity or lipid peroxidation versus placebo.
In pregnant women with type 1 diabetes, maternal vitamin C/E supplementation did not increase placental or cord vitamin levels nor change placental antioxidant enzyme activity or lipid peroxidation versus placebo.
In overweight/obese adults, acute intra-arterial vitamin C greatly increased endothelial t-PA release, and 3 months of oral vitamin C (500 mg/day) also increased t-PA release compared with before supplementation.
In overweight/obese adults, acute intra-arterial vitamin C greatly increased endothelial t-PA release, and 3 months of oral vitamin C (500 mg/day) also increased t-PA release compared with before supplementation.
500 mg/day vitamin C for 12 weeks did not significantly lower serum uric acid overall; subgroup with higher baseline uric acid showed a significant reduction.
Smokers who drank milk supplemented with fruit/vegetable extracts and vitamin C twice daily for 6 weeks had higher plasma vitamin C and antioxidant potential and lower uric acid than non‑supplemented milk.
In hemodialysis patients, giving 250 mg vitamin C three times weekly for 8 weeks lowered serum uric acid but did not change creatinine.
In a double-blind RCT, 500 mg/day vitamin C for 2 months lowered serum uric acid by about 0.5 mg/dl and increased estimated GFR.
In women with severe early pre-eclampsia, combined antioxidant therapy (including vitamin C) did not clearly improve biochemical markers or clinical prolongation of pregnancy.
Daily oral collagen tripeptide (3 g) improved skin hydration and elasticity and tended to reduce transepidermal water loss over 12 weeks compared with no supplement.
Randomized placebo‑controlled 12‑week trial in 72 women: daily drinkable collagen peptides + dermonutrients improved objective measures of skin appearance versus placebo.
Perioperative vitamin C+E reduced markers of lipid peroxidation and increased antioxidant enzyme activity and plasma antioxidant vitamin levels versus control.
Perioperative vitamin C+E reduced markers of lipid peroxidation and increased antioxidant enzyme activity and plasma antioxidant vitamin levels versus control.
A 6-month antioxidant regimen including vitamin C raised blood antioxidant levels but did not change liver enzymes or hepatitis C viral load.
Perioperative vitamin C+E reduced markers of lipid peroxidation and increased antioxidant enzyme activity and plasma antioxidant vitamin levels versus control.
In 40 gout patients, 500 mg/day vitamin C for 8 weeks raised plasma ascorbate but produced only a very small and clinically insignificant decrease in serum urate compared with allopurinol.
Randomized study in 89 patients receiving 131I comparing vitamin E, vitamin C, and supragingival scaling with vitamin C; vitamin E protected parotid excretion function, and supragingival scaling with vitamin C improved uptake indices and excretion rates and attenuated serum amylase reduction.
Randomized study in 89 patients receiving 131I comparing vitamin E, vitamin C, and supragingival scaling with vitamin C; vitamin E protected parotid excretion function, and supragingival scaling with vitamin C improved uptake indices and excretion rates and attenuated serum amylase reduction.
Randomized study in 89 patients receiving 131I comparing vitamin E, vitamin C, and supragingival scaling with vitamin C; vitamin E protected parotid excretion function, and supragingival scaling with vitamin C improved uptake indices and excretion rates and attenuated serum amylase reduction.
Intraoperative IV vitamin C (3 g total given in three 1 g doses) reduced postoperative pulmonary complication (PPC) scores and lowered the incidence of PPCs versus saline in low-risk cardiac surgery patients.
Intraoperative IV vitamin C (3 g total given in three 1 g doses) reduced postoperative pulmonary complication (PPC) scores and lowered the incidence of PPCs versus saline in low-risk cardiac surgery patients.
In burned children, combined vitamin C+E+zinc lowered lipid peroxidation and sped wound healing compared with placebo.
In burned children, combined vitamin C+E+zinc lowered lipid peroxidation and sped wound healing compared with placebo.
In burned children, combined vitamin C+E+zinc lowered lipid peroxidation and sped wound healing compared with placebo.
In healthy elderly adults, 6 months of 500–1000 mg ascorbic acid plus 400 IU vitamin E did not significantly change oxidative stress markers, antioxidant enzymes, or DNA damage versus placebo.
In a double-blind RCT, 500 mg/day vitamin C for 2 months lowered serum uric acid by about 0.5 mg/dl and increased estimated GFR.
Perioperative IV vitamin C did not reduce postoperative AKI or improve eGFR after on-pump cardiac surgery; MDA (oxidative stress marker) was not reduced and was higher on POD1 in a subgroup.
Statin plus ascorbic acid reduced the incidence of post-contrast acute kidney injury compared to placebo, though serum creatinine and eGFR changes were not improved between groups.
Topical 20% vitamin C daily produced >50% improvement in under-eye pigmentation in about 27% of patients over 12 weeks and was less effective than chemical peels.
Topical 20% vitamin C daily produced >50% improvement in under-eye pigmentation in about 27% of patients over 12 weeks and was less effective than chemical peels.
Double-blind RCT in post-menopausal women (159 completers) testing an oral multi-ingredient supplement (not collagen); reported reduced wrinkle depth and increased skin collagen deposition in biopsies.
Daily supplementation (vitamin C + E + zinc + selenium) for 17 weeks improved quadriceps maximal voluntary contraction and endurance and altered antioxidant markers, but did not improve 2-minute walk distance.
In a double-blind RCT, maternal 500 mg/day vitamin C in the last month of pregnancy significantly reduced neonatal total bilirubin measured on day 5.
Vitamin C acutely increased endothelium-dependent vasodilation (ACh-mediated forearm blood flow) in hypercholesterolemic patients.
Vitamin C acutely increased endothelium-dependent vasodilation (ACh-mediated forearm blood flow) in hypercholesterolemic patients.
Vitamin C acutely increased endothelium-dependent vasodilation (ACh-mediated forearm blood flow) in hypercholesterolemic patients.
A single 2 g oral dose of vitamin C (with or without vitamin E) acutely increased radial artery flow, lumen diameter and area in patients awaiting CABG.
A single 2 g oral dose of vitamin C (with or without vitamin E) acutely increased radial artery flow, lumen diameter and area in patients awaiting CABG.
A single 2 g oral dose of vitamin C (with or without vitamin E) acutely increased radial artery flow, lumen diameter and area in patients awaiting CABG.
Vitamin C (200 mg) and/or vitamin E (400 mg) taken for 8 weeks reduced restless legs symptom scores (~10-point drop) versus placebo (~3-point drop) in hemodialysis patients.
Adding oral vitamin C to atypical antipsychotics for 8 weeks reduced oxidative stress markers and improved psychiatric rating scores in schizophrenia patients.
Adding oral vitamin C to atypical antipsychotics for 8 weeks reduced oxidative stress markers and improved psychiatric rating scores in schizophrenia patients.
Over 5 years, higher-dose vitamin C (500 mg/day) attenuated the decline in PGI/II ratio versus 50 mg/day, suggesting reduced progression of gastric mucosal atrophy.
In a 4-week randomized study, adding mandarin juice (rich in vitamin C and other antioxidants) to a low-calorie diet in obese children reduced oxidative stress markers and greatly increased plasma vitamin C.
IV vitamin C raised plasma levels and substantially reduced spontaneous pain in patients with postherpetic neuralgia but did not affect brush-evoked pain.
IV vitamin C raised plasma levels and substantially reduced spontaneous pain in patients with postherpetic neuralgia but did not affect brush-evoked pain.
One-week oral antioxidant regimens showed that vitamin E alone and vitamin E plus vitamin C increased minimal erythema dose (photoprotection), whereas vitamin C alone did not.
Six daily 250 mg vitamin C vaginal tablets significantly increased cure rates of bacterial vaginosis versus placebo and were well tolerated.
Six daily 250 mg vitamin C vaginal tablets significantly increased cure rates of bacterial vaginosis versus placebo and were well tolerated.
14-day high-dose vitamin C (3000 mg/day) increased penile-vaginal intercourse frequency and reduced depression scores versus placebo.
14-day high-dose vitamin C (3000 mg/day) increased penile-vaginal intercourse frequency and reduced depression scores versus placebo.
4-month antioxidant supplement (vitamin C as part of a combination) increased antioxidant status, reduced oxidative stress marker and modestly lowered ALT but did not change inflammatory markers.
4-month antioxidant supplement (vitamin C as part of a combination) increased antioxidant status, reduced oxidative stress marker and modestly lowered ALT but did not change inflammatory markers.
In hepatitis C patients receiving interferon and ribavirin, vitamins E+C kept a fatty acid (EPA) level stable and raised blood vitamin levels.
4-month antioxidant supplement (vitamin C as part of a combination) increased antioxidant status, reduced oxidative stress marker and modestly lowered ALT but did not change inflammatory markers.
In children with NAFLD, adding vitamin E plus vitamin C to diet/exercise did not improve liver enzymes, insulin resistance, or weight loss compared with placebo.
Vitamin C 1000 mg/day for 2 months raised serum and follicular-fluid vitamin C but did not change measured oxidative stress markers or IVF implantation and clinical pregnancy rates.
Vitamin C 1000 mg/day for 2 months raised serum and follicular-fluid vitamin C but did not change measured oxidative stress markers or IVF implantation and clinical pregnancy rates.
Vitamin C 1000 mg/day for 2 months raised serum and follicular-fluid vitamin C but did not change measured oxidative stress markers or IVF implantation and clinical pregnancy rates.
Vitamin C 50 mg/day in premature infants increased plasma vitamin C but did not increase hemolysis markers, bilirubin, or other morbidities versus placebo.
Vitamin C 50 mg/day in premature infants increased plasma vitamin C but did not increase hemolysis markers, bilirubin, or other morbidities versus placebo.
Over 12 months, vitamin C 500 mg/day did not reduce plasma F2-isoprostanes (a lipid peroxidation marker), whereas vitamin E did.
In thyroid cancer patients given therapeutic 131I, sucking vitamin C at various times had only a limited effect on salivary radioiodine dose.
Vitamin C supplementation improved soft‑tissue healing after dental implant surgery in several patient subgroups but did not reduce pain.
In this small pediatric RCT, adding 1000 mg/day vitamin C to fluoxetine produced greater reductions in depressive symptom scores (CDRS, CDI) versus placebo; no effect on CGI.
In this small pediatric RCT, adding 1000 mg/day vitamin C to fluoxetine produced greater reductions in depressive symptom scores (CDRS, CDI) versus placebo; no effect on CGI.
In this small pediatric RCT, adding 1000 mg/day vitamin C to fluoxetine produced greater reductions in depressive symptom scores (CDRS, CDI) versus placebo; no effect on CGI.
In young smokers, vitamin C alone did not change LDL oxidizability or neutrophil respiratory burst; vitamin E increased LDL oxidation lag time and combined E+C reduced oxidation rate.
In young smokers, vitamin C alone did not change LDL oxidizability or neutrophil respiratory burst; vitamin E increased LDL oxidation lag time and combined E+C reduced oxidation rate.
High‑dose vitamin C alone (2 g/day) did not improve endothelial function or most thrombosis/fibrinolysis markers in smokers, but combined high‑dose C+E improved endothelial-dependent dilation and reduced some thrombosis markers at higher E dose.
High‑dose vitamin C alone (2 g/day) did not improve endothelial function or most thrombosis/fibrinolysis markers in smokers, but combined high‑dose C+E improved endothelial-dependent dilation and reduced some thrombosis markers at higher E dose.
High‑dose vitamin C alone (2 g/day) did not improve endothelial function or most thrombosis/fibrinolysis markers in smokers, but combined high‑dose C+E improved endothelial-dependent dilation and reduced some thrombosis markers at higher E dose.
Intravenous vitamin C given during dialysis for 8 weeks lowered blood phosphorus and inflammation markers.
Intravenous vitamin C given during dialysis for 8 weeks lowered blood phosphorus and inflammation markers.
Intravenous vitamin C given during dialysis for 8 weeks lowered blood phosphorus and inflammation markers.
Adding the multi-ingredient supplement (contains vitamin C) to standard drug treatment increased the proportion of patients with marked hair improvement at 6 months.
Adding the multi-ingredient supplement (contains vitamin C) to standard drug treatment increased the proportion of patients with marked hair improvement at 6 months.
Adding the multi-ingredient supplement (contains vitamin C) to standard drug treatment increased the proportion of patients with marked hair improvement at 6 months.
Six years of combined slow-release vitamin C and vitamin E slowed carotid atherosclerosis progression, with larger effects in men.
Six years of combined slow-release vitamin C and vitamin E slowed carotid atherosclerosis progression, with larger effects in men.
High-dose IV vitamin C added to steroids improved hearing recovery in sudden sensorineural hearing loss compared with steroids alone.
High-dose IV vitamin C added to steroids improved hearing recovery in sudden sensorineural hearing loss compared with steroids alone.
Hemodialysis patients given 250 mg vitamin C every other day for 12 weeks had higher blood vitamin C, lower oxidative stress marker, and improved cholesterol/LDL measures.
Hemodialysis patients given 250 mg vitamin C every other day for 12 weeks had higher blood vitamin C, lower oxidative stress marker, and improved cholesterol/LDL measures.
Daily 250 mg vitamin C vaginal tablets for 6 days reduced signs and recurrence of non-specific vaginitis versus placebo.
Daily 250 mg vitamin C vaginal tablets for 6 days reduced signs and recurrence of non-specific vaginitis versus placebo.
Daily 250 mg vitamin C vaginal tablets for 6 days reduced signs and recurrence of non-specific vaginitis versus placebo.
Daily vitamin C supplement over 60 days reduced the number of colds and shortened severe symptom duration compared with placebo.
Daily vitamin C supplement over 60 days reduced the number of colds and shortened severe symptom duration compared with placebo.
Daily vitamin C supplement over 60 days reduced the number of colds and shortened severe symptom duration compared with placebo.
Vitamin C given daily after wrist fracture significantly reduced the risk of complex regional pain syndrome; 500 mg/day for 50 days recommended.
Vitamin C given daily after wrist fracture significantly reduced the risk of complex regional pain syndrome; 500 mg/day for 50 days recommended.
In adults, plasma vitamin C correlated inversely with adiposity measures; in a small weight-loss trial both vitamin C and placebo groups lost weight and showed similar increases in adiponectin.
In adults, plasma vitamin C correlated inversely with adiposity measures; in a small weight-loss trial both vitamin C and placebo groups lost weight and showed similar increases in adiponectin.
In adults, plasma vitamin C correlated inversely with adiposity measures; in a small weight-loss trial both vitamin C and placebo groups lost weight and showed similar increases in adiponectin.
A 4-month high-antioxidant diet (designed to raise vitamins A, C and E) increased plasma and leukocyte vitamin C, boosted antioxidant enzyme activities, and lowered lipid oxidative markers in women with endometriosis.
Randomized dietary intervention (0.5 vs 2 kiwifruit/day) in healthy young men showing plasma and skeletal muscle ascorbate increase after 6 weeks; muscle ascorbate rose ≈3.5‑fold and correlated with plasma levels.
In NASH patients, combined vitamin E and vitamin C for 6 months improved liver fibrosis scores but did not change inflammation or ALT.
Daily 500 mg vitamin C for 50 days after wrist fracture reduced the 1-year occurrence of reflex sympathetic dystrophy compared with placebo.
Four-week multi-antioxidant supplementation (including 1500 mg/day vitamin C) raised serum vitamin levels but did not change markers of oxidative stress, airway inflammation, or allergen-specific immune responses.
Four-week multi-antioxidant supplementation (including 1500 mg/day vitamin C) raised serum vitamin levels but did not change markers of oxidative stress, airway inflammation, or allergen-specific immune responses.
In 67 nonsmokers exposed to environmental tobacco smoke, daily vitamin C reduced a plasma oxidative stress biomarker (F2-isoprostanes) over two months.
In smokers with higher BMI, 500 mg/day vitamin C for 2 months lowered a blood marker of lipid oxidation; no effect in low-BMI smokers.
In vitamin C–deficient young β-thalassemia major patients, adding 100 mg/day vitamin C to chelation therapy (especially with deferoxamine) improved iron-related measures over 1 year without adverse events.
Children with β-thalassemia and low vitamins received combined vitamin therapy for 12 months and showed improved antioxidant markers and reduced liver iron.
In vitamin C–deficient young β-thalassemia major patients, adding 100 mg/day vitamin C to chelation therapy (especially with deferoxamine) improved iron-related measures over 1 year without adverse events.
In vitamin C–deficient young β-thalassemia major patients, adding 100 mg/day vitamin C to chelation therapy (especially with deferoxamine) improved iron-related measures over 1 year without adverse events.
Twelve weeks of vitamin C (500 mg twice daily) plus vitamin E raised plasma and gastric-juice vitamin C but did not change gastric mucosal oxidative markers or DNA damage versus placebo.
Twelve weeks of vitamin C (500 mg twice daily) plus vitamin E raised plasma and gastric-juice vitamin C but did not change gastric mucosal oxidative markers or DNA damage versus placebo.
Twelve weeks of vitamin C (500 mg twice daily) plus vitamin E raised plasma and gastric-juice vitamin C but did not change gastric mucosal oxidative markers or DNA damage versus placebo.
A 12-week randomized trial in young children found the herbal product containing echinacea, propolis and vitamin C reduced respiratory infections and fever days versus placebo.
A 12-week randomized trial in young children found the herbal product containing echinacea, propolis and vitamin C reduced respiratory infections and fever days versus placebo.
A 12-week randomized trial in young children found the herbal product containing echinacea, propolis and vitamin C reduced respiratory infections and fever days versus placebo.
In a 4-week crossover trial of 500 mg/day vitamin C in healthy smokers, plasma ascorbate rose but markers of oxidation and endothelial activation did not change.
In a 4-week crossover trial of 500 mg/day vitamin C in healthy smokers, plasma ascorbate rose but markers of oxidation and endothelial activation did not change.
Thirty-three days of a high-dose B‑vitamin/mineral product (including 500 mg vitamin C) improved some mood scores, reduced perceived stress and increased some cognitive task correct responses in healthy men.
Thirty-three days of a high-dose B‑vitamin/mineral product (including 500 mg vitamin C) improved some mood scores, reduced perceived stress and increased some cognitive task correct responses in healthy men.
Thirty-three days of a high-dose B‑vitamin/mineral product (including 500 mg vitamin C) improved some mood scores, reduced perceived stress and increased some cognitive task correct responses in healthy men.
In healthy young adults a single antioxidant cocktail (including vitamin C) taken before a high-sodium meal did not change endothelial function or arterial stiffness compared with placebo.
Double-blind RCT of blackcurrant juice rich in vitamin C and polyphenols for 6 weeks: raised plasma vitamin C, lowered oxidative stress and improved endothelial function.
Antioxidant vitamins including vitamin C (500 mg twice daily) did not improve flow-mediated dilation or nitroglycerin-induced dilation in postmenopausal women with coronary artery disease.
In patients with intermittent claudication, vitamin C administration prevented exercise-induced impairment of endothelial function and rises in oxidative stress markers.
In CAD patients, folic acid supplementation markedly raised plasma folate and produced a modest homocysteine fall and a significant improvement in flow-mediated dilation versus placebo; adding antioxidants did not produce significant additional benefit.
Children conceived by ART given vitamins C (1 g) and E (400 IU) for 4 weeks showed improved NO levels, better brachial FMD and lower pulmonary artery pressure versus placebo (effects seen in ART children only).
In postmenopausal women, estrogen treatment enabled exercise to improve endothelial function; intravenous ascorbic acid infusion increased endothelial function in certain groups.
In patients undergoing bilateral knee replacement, intraoperative high‑dose IV vitamin C was associated with lower oxidative stress markers and lower postoperative troponin I compared with controls.
In patients undergoing bilateral knee replacement, intraoperative high‑dose IV vitamin C was associated with lower oxidative stress markers and lower postoperative troponin I compared with controls.
In patients undergoing bilateral knee replacement, intraoperative high‑dose IV vitamin C was associated with lower oxidative stress markers and lower postoperative troponin I compared with controls.
In critically ill patients with TRALI, high-dose IV vitamin C (2.5 g every 6 h for 96 h) reduced pro-inflammatory and oxidative stress markers and increased anti-inflammatory and antioxidant markers versus placebo.
In critically ill patients with TRALI, high-dose IV vitamin C (2.5 g every 6 h for 96 h) reduced pro-inflammatory and oxidative stress markers and increased anti-inflammatory and antioxidant markers versus placebo.
In critically ill patients with TRALI, high-dose IV vitamin C (2.5 g every 6 h for 96 h) reduced pro-inflammatory and oxidative stress markers and increased anti-inflammatory and antioxidant markers versus placebo.
Compared calcium ascorbate (CA) vs ascorbic acid (AA) in crossover trials: 250 mg showed no differences; 500 mg CA altered vitamin C kinetics and increased neutrophil phagocytosis and certain NK cells.
Compared calcium ascorbate (CA) vs ascorbic acid (AA) in crossover trials: 250 mg showed no differences; 500 mg CA altered vitamin C kinetics and increased neutrophil phagocytosis and certain NK cells.
Compared calcium ascorbate (CA) vs ascorbic acid (AA) in crossover trials: 250 mg showed no differences; 500 mg CA altered vitamin C kinetics and increased neutrophil phagocytosis and certain NK cells.
In corticosteroid‑dependent asthma patients, adding antioxidants including CoQ10, vitamin E and 250 mg vitamin C/day was associated with reduced corticosteroid requirements.
In acute amitriptyline intoxication cases, supplementation with antioxidants (alpha lipoic acid with or without vitamin C) reduced oxidative stress markers more than routine treatment, greatest with combination.
In 50 female patients with mixed melasma, salicylic acid peel plus intradermal vitamin C mesotherapy and peel alone both reduced pigmentation severity and improved quality-of-life; combination was safe and well tolerated.
In 50 female patients with mixed melasma, salicylic acid peel plus intradermal vitamin C mesotherapy and peel alone both reduced pigmentation severity and improved quality-of-life; combination was safe and well tolerated.
In 50 female patients with mixed melasma, salicylic acid peel plus intradermal vitamin C mesotherapy and peel alone both reduced pigmentation severity and improved quality-of-life; combination was safe and well tolerated.
In 32 diabetic patients with low plasma vitamin C, high-dose oral vitamin C partially restored vitamin C levels but did not improve endothelial function or measures of insulin resistance.
In 32 diabetic patients with low plasma vitamin C, high-dose oral vitamin C partially restored vitamin C levels but did not improve endothelial function or measures of insulin resistance.
In a large trial of male smokers, dietary vitamin C intake modified the effect of vitamin E on mortality, with opposite effects in some age subgroups.
In a large trial of male smokers, dietary vitamin C intake modified the effect of vitamin E on mortality, with opposite effects in some age subgroups.
In a large trial of male smokers, dietary vitamin C intake modified the effect of vitamin E on mortality, with opposite effects in some age subgroups.
Three-year RCT found combined vitamin E + slow‑release vitamin C slowed carotid IMT progression in men versus placebo.
Three-year RCT found combined vitamin E + slow‑release vitamin C slowed carotid IMT progression in men versus placebo.
In chronic smokers, vitamin C alone improved endothelial function; adding Enzogenol gave additional reductions in protein oxidation and fibrinogen but no extra macrovascular benefit.
In a crossover human experiment, vitamin C infusion during recovery from hypoglycemia with hyperglycemia attenuated the worsening of endothelial function and increases in oxidative stress and inflammation.
In chronic smokers, vitamin C alone improved endothelial function; adding Enzogenol gave additional reductions in protein oxidation and fibrinogen but no extra macrovascular benefit.
In chronic smokers, vitamin C alone improved endothelial function; adding Enzogenol gave additional reductions in protein oxidation and fibrinogen but no extra macrovascular benefit.
In a small RCT of sepsis patients, high‑dose IV vitamin C transiently improved early microvascular perfusion (PPV) and reduced a glycocalyx metric in the smallest capillaries, with no change in mortality.
In a small RCT of sepsis patients, high‑dose IV vitamin C transiently improved early microvascular perfusion (PPV) and reduced a glycocalyx metric in the smallest capillaries, with no change in mortality.
In hepatitis C patients receiving interferon and ribavirin, vitamins E+C kept a fatty acid (EPA) level stable and raised blood vitamin levels.
In hypercholesterolemic patients, vitamin C coinfusion acutely improved endothelium-dependent vasodilation before statin therapy but not after short-term statin treatment.
In healthy older people, oral vitamin C raised blood vitamin levels but did not improve vascular dilation; a Mediterranean-type diet did improve vascular function.
A fruit/vegetable purée drink acutely raised plasma vitamin C and plasma antioxidant capacity and showed a trend toward improved endothelium-dependent vasodilation.
Daily fruit-and-vegetable puree drinks raised dietary vitamin C and plasma carotenoids and produced a trend toward improved endothelium-dependent vasodilation.
In healthy older people, oral vitamin C raised blood vitamin levels but did not improve vascular dilation; a Mediterranean-type diet did improve vascular function.
Oral antioxidant combination including vitamin C (1,000 mg) improved endothelium-dependent vasodilation in type 1 but not type 2 diabetic patients after 6 months.
High-dose oral vitamin C for 12 months in children with CMT1A was safe but did not meaningfully improve nerve conduction, strength, function, or quality of life.
High-dose oral vitamin C for 12 months in children with CMT1A was safe but did not meaningfully improve nerve conduction, strength, function, or quality of life.
Topical stable vitamin C derivative (5%) significantly improved acne severity and lesion counts versus vehicle over 12 weeks with similar tolerability.
Topical stable vitamin C derivative (5%) significantly improved acne severity and lesion counts versus vehicle over 12 weeks with similar tolerability.
Topical stable vitamin C derivative (5%) significantly improved acne severity and lesion counts versus vehicle over 12 weeks with similar tolerability.
One tablet daily containing iron plus vitamin C for four weeks raised hemoglobin, hematocrit, serum iron, and vitamin C without increasing plasma oxalate in dialysis patients.
One tablet daily containing iron plus vitamin C for four weeks raised hemoglobin, hematocrit, serum iron, and vitamin C without increasing plasma oxalate in dialysis patients.
In nulliparous pregnant women, combined vitamins C and E (with iron) from mid-pregnancy reduced the rate of preeclampsia compared with iron alone.
Drinking concentrated beetroot juice (high nitrate) raised urinary nitrate, nitrite and N‑nitroso compounds; 1000 mg vitamin C blocked the immediate (one-dose) rise in N‑nitroso compounds but not after seven days.
Drinking concentrated beetroot juice (high nitrate) raised urinary nitrate, nitrite and N‑nitroso compounds; 1000 mg vitamin C blocked the immediate (one-dose) rise in N‑nitroso compounds but not after seven days.
Drinking concentrated beetroot juice (high nitrate) raised urinary nitrate, nitrite and N‑nitroso compounds; 1000 mg vitamin C blocked the immediate (one-dose) rise in N‑nitroso compounds but not after seven days.
High-dose IV ascorbic acid during the first 24 hours after major burns reduced fluid needs, edema/weight gain, and duration of mechanical ventilation.
In 80 ICU patients with severe pneumonia, high‑dose IV vitamin C (60 mg/kg/day for 96 h) was safe and associated with shorter mechanical ventilation and vasopressor durations and improved organ‑failure markers, but mortality difference was not statistically significant.
In 80 ICU patients with severe pneumonia, high‑dose IV vitamin C (60 mg/kg/day for 96 h) was safe and associated with shorter mechanical ventilation and vasopressor durations and improved organ‑failure markers, but mortality difference was not statistically significant.
In 80 ICU patients with severe pneumonia, high‑dose IV vitamin C (60 mg/kg/day for 96 h) was safe and associated with shorter mechanical ventilation and vasopressor durations and improved organ‑failure markers, but mortality difference was not statistically significant.
In 111 septic shock patients, IV vitamin C plus thiamine for 48 h raised blood vitamin levels but did not improve organ dysfunction (ΔSOFA) or mortality compared with placebo.
Dietary vitamin C enrichment (500 mg/day) in young men increased plasma ascorbic acid and reduced the susceptibility of lipoproteins to oxidation.
Phase I randomized placebo-controlled trial (severe sepsis) showed IV ascorbic acid rapidly restored plasma levels, was well tolerated, reduced inflammatory biomarkers and was associated with faster declines in SOFA scores versus placebo.
Oral ascorbic acid markedly raised plasma ascorbate levels but did not improve brachial artery flow‑mediated (endothelium-dependent) dilation in hypertensive patients; chronic treatment previously reported to lower blood pressure.
Postoperative ICU patients given an intravenous ascorbic acid substitution overnight reached normal/high-normal plasma ascorbic acid concentrations.
Vitamin C quickly and sustainably improved blood-vessel dilation in patients with coronary artery disease.
Phase I randomized placebo-controlled trial (severe sepsis) showed IV ascorbic acid rapidly restored plasma levels, was well tolerated, reduced inflammatory biomarkers and was associated with faster declines in SOFA scores versus placebo.
Phase I randomized placebo-controlled trial (severe sepsis) showed IV ascorbic acid rapidly restored plasma levels, was well tolerated, reduced inflammatory biomarkers and was associated with faster declines in SOFA scores versus placebo.
In a long-term (5 year) randomized trial among participants taking vitamin C (50 mg or 500 mg daily), systolic blood pressure increased over time in all groups and high‑dose vitamin C did not reduce blood pressure.
Among 322 acutely ill older inpatients, biochemical vitamin C depletion was common and associated with higher depression symptom scores at baseline and at 6 weeks.
Among 322 acutely ill older inpatients, biochemical vitamin C depletion was common and associated with higher depression symptom scores at baseline and at 6 weeks.
Among 322 acutely ill older inpatients, biochemical vitamin C depletion was common and associated with higher depression symptom scores at baseline and at 6 weeks.
In 56 healthy smokers randomized to 500 mg vitamin C daily or placebo for 4 weeks, plasma vitamin C increased but markers of lipid peroxidation and pulmonary function tests did not change.
In a 4-week double-blind crossover trial, combined high-dose vitamin C and E lowered urinary albumin excretion in Type 2 diabetic patients.
In a 4-week double-blind crossover trial, combined high-dose vitamin C and E lowered urinary albumin excretion in Type 2 diabetic patients.
Topical oil‑soluble vitamin C derivative applied twice daily for 8 weeks improved periorbital wrinkles versus placebo on the contralateral side.
Smokers who drank milk supplemented with fruit/vegetable extracts and vitamin C twice daily for 6 weeks had higher plasma vitamin C and antioxidant potential and lower uric acid than non‑supplemented milk.
Smokers who drank milk supplemented with fruit/vegetable extracts and vitamin C twice daily for 6 weeks had higher plasma vitamin C and antioxidant potential and lower uric acid than non‑supplemented milk.
In a 28-day randomized trial, a multivitamin/mineral supplement (including minerals) produced small self-reported improvements in physical stamina, concentration/mental stamina, and alertness in working men.
In a 28-day randomized trial, a multivitamin/mineral supplement (including minerals) produced small self-reported improvements in physical stamina, concentration/mental stamina, and alertness in working men.
In a 28-day randomized trial, a multivitamin/mineral supplement (including minerals) produced small self-reported improvements in physical stamina, concentration/mental stamina, and alertness in working men.
In a controlled-diet depletion–repletion study, plasma ascorbate achieved on identical intake varied widely and was inversely associated with body weight and influenced by prior depletion.
In a controlled-diet depletion–repletion study, plasma ascorbate achieved on identical intake varied widely and was inversely associated with body weight and influenced by prior depletion.
In a controlled-diet depletion–repletion study, plasma ascorbate achieved on identical intake varied widely and was inversely associated with body weight and influenced by prior depletion.
IV 2 g ascorbic acid given perioperatively did not reduce intraoperative blood loss or change operative outcomes in women undergoing laparoscopic myomectomy.
IV 2 g ascorbic acid given perioperatively did not reduce intraoperative blood loss or change operative outcomes in women undergoing laparoscopic myomectomy.
A revised parenteral nutrition formula restored vitamin C and other vitamin levels to normal ranges after gastrointestinal surgery.
In iron-deficient non-anemic girls, iron therapy with or without added vitamin C improved oxidative stress markers; adding vitamin C did not further change TAC or MDA but raised serum vitamin C levels more.
Low-dose vitamin supplementation (including 120 mg vitamin C) for 2 years increased nutrient levels and improved a red blood cell antioxidant resistance assay in elderly participants.
In patients with acute MI, adjunctive antioxidant vitamins C+E for 30 days modestly reduced a composite in-hospital adverse cardiac endpoint versus placebo.
Daily 400 mg vitamin C added to routine antenatal vitamins was associated with fewer hospitalizations and fewer low-birth-weight infants in this Ugandan cohort.
Daily 400 mg vitamin C added to routine antenatal vitamins was associated with fewer hospitalizations and fewer low-birth-weight infants in this Ugandan cohort.
Daily 400 mg vitamin C added to routine antenatal vitamins was associated with fewer hospitalizations and fewer low-birth-weight infants in this Ugandan cohort.
In acute amitriptyline intoxication cases, supplementation with antioxidants (alpha lipoic acid with or without vitamin C) reduced oxidative stress markers more than routine treatment, greatest with combination.
In SLE patients, 12 weeks of combined vitamins C and E increased plasma vitamin levels and reduced MDA but did not change endothelial function measures.
In critically ill patients, supplementation with vitamins A, C and E reduced lipid peroxidation (MDA) and altered antioxidant vitamin levels but did not change clinical outcomes (ventilation, mortality, length of stay).
In critically ill patients, supplementation with vitamins A, C and E reduced lipid peroxidation (MDA) and altered antioxidant vitamin levels but did not change clinical outcomes (ventilation, mortality, length of stay).
In people at risk for type 2 diabetes, blood vitamin C levels were positively associated with immune-related serum proteins and a 21-feature signature (including proteins and clinical variables) predicted vitamin C levels.
Randomized, double-blind crossover in 25 mildly anemic children found adding equimolar ascorbic acid to iron-fortified milk (both drinks contained calcium) nearly doubled fractional iron absorption versus iron alone.
Intravenous antioxidant therapy (including vitamin C) raised antioxidant levels and lowered oxidative stress markers but did not reduce organ dysfunction at 7 days in severe acute pancreatitis.
Adding vitamins C and E to standard triple therapy substantially increased H. pylori eradication rates compared with standard therapy alone.
Daily vitamins C and E in high-risk pregnant women did not reduce pre-eclampsia or improve maternal/perinatal outcomes.
Follow-up of an RCT where pregnant smokers received 500 mg/day vitamin C or placebo; at age 5 offspring of vitamin C mothers had better small-airway function, less wheeze, and persistent buccal DNA methylation differences.
Follow-up of an RCT where pregnant smokers received 500 mg/day vitamin C or placebo; at age 5 offspring of vitamin C mothers had better small-airway function, less wheeze, and persistent buccal DNA methylation differences.
Follow-up of an RCT where pregnant smokers received 500 mg/day vitamin C or placebo; at age 5 offspring of vitamin C mothers had better small-airway function, less wheeze, and persistent buccal DNA methylation differences.
In 69 postoperative thyroid cancer patients receiving 131I, antioxidant regimens (vitamin E+C, selenium, selenium+C) were associated with improved salivary gland function parameters one month after treatment.
In 69 postoperative thyroid cancer patients receiving 131I, antioxidant regimens (vitamin E+C, selenium, selenium+C) were associated with improved salivary gland function parameters one month after treatment.
In patients with cirrhosis, IV ascorbic acid reduced oxidative marker MDA and markedly blunted the postprandial rise in portal pressure.
120 subjects (4 groups) showed lower plasma vitamin C in gingivitis/periodontitis; short-term dietary vitamin C (450 mg/day) plus scaling reduced bleeding in gingivitis and diabetic periodontitis subgroups.
In 51 high‑risk premature infants, daily ascorbic acid (100 mg/kg) during the first week prevented the normal postnatal drop in levels and was not associated with increased hemolysis or short‑term adverse outcomes.
Grapefruit intake for 2 weeks increased blood vitamin C and reduced gum bleeding in periodontitis patients.
120 subjects (4 groups) showed lower plasma vitamin C in gingivitis/periodontitis; short-term dietary vitamin C (450 mg/day) plus scaling reduced bleeding in gingivitis and diabetic periodontitis subgroups.
A 3-month trial of a polyphenol-rich antioxidant supplement (pomegranate, green tea extracts, plus ascorbic acid) in type 2 diabetics lowered LDL and MDA and increased antioxidant markers compared with placebo.
Higher blood vitamin C was associated with lower odds of mild dementia in this cross-sectional case-control study of older adults.
In hyperlipidemic patients, 500 mg vitamin C daily for 10 weeks increased blood vitamin C and was associated with reductions in total cholesterol, apo-B, and MDA versus baseline.
In hyperlipidemic patients, 500 mg vitamin C daily for 10 weeks increased blood vitamin C and was associated with reductions in total cholesterol, apo-B, and MDA versus baseline.
In healthy men given endotoxin, high‑dose IV vitamin C restored endothelial-dependent forearm vasodilation that was suppressed by endotoxin.
Children whose mothers (smokers) received vitamin C in pregnancy had higher expiratory flow measures at age 5, but forced oscillation measures largely did not detect the effect.
Children whose mothers (smokers) received vitamin C in pregnancy had higher expiratory flow measures at age 5, but forced oscillation measures largely did not detect the effect.
Children whose mothers (smokers) received vitamin C in pregnancy had higher expiratory flow measures at age 5, but forced oscillation measures largely did not detect the effect.
Oral 500 mg/day vitamin C for 4 weeks lowered blood pressure and improved arterial stiffness measures in patients with type 2 diabetes.
Oral 500 mg/day vitamin C for 4 weeks lowered blood pressure and improved arterial stiffness measures in patients with type 2 diabetes.
Oral 500 mg/day vitamin C for 4 weeks lowered blood pressure and improved arterial stiffness measures in patients with type 2 diabetes.
In overweight/obese nonsmokers, 1000 mg/day vitamin C for 2 months reduced plasma F2-isoprostanes, especially in participants with high baseline levels.
In overweight/obese nonsmokers, 1000 mg/day vitamin C for 2 months reduced plasma F2-isoprostanes, especially in participants with high baseline levels.
Vaginal vitamin C insertion improved normalization of vaginal flora and pH versus no treatment but caused irritation in some women.
Vaginal vitamin C insertion improved normalization of vaginal flora and pH versus no treatment but caused irritation in some women.
Urinary 8-epi-PGF2α (a free-radical marker) rose transiently after primary PTCA; pre-treatment with vitamin C did not suppress this rise.
In elderly men undergoing 12 weeks of resistance training, high-dose vitamin C+E supplementation blunted exercise-induced gains in bone mineral density and altered some bone-related serum markers.
In elderly men undergoing 12 weeks of resistance training, high-dose vitamin C+E supplementation blunted exercise-induced gains in bone mineral density and altered some bone-related serum markers.
A multicomponent supplement (containing vitamin C among others) lowered leukocyte counts in smokers and increased plasma vitamin E and Q10; effects cannot be attributed solely to vitamin C.
In healthy middle-aged adults, 7-week supplementation with fruit/vegetable concentrates raised blood levels of several antioxidants including vitamin C.
A multicomponent supplement (containing vitamin C among others) lowered leukocyte counts in smokers and increased plasma vitamin E and Q10; effects cannot be attributed solely to vitamin C.
Children with chronic constipation had lower antioxidant enzyme activities and lower plasma vitamin C and E compared with matched healthy children.
A multicomponent supplement (containing vitamin C among others) lowered leukocyte counts in smokers and increased plasma vitamin E and Q10; effects cannot be attributed solely to vitamin C.
A dentifrice containing an ascorbic acid derivative showed reduced gingival redness and higher salivary antioxidant activity; primary GI outcome was not significant in ITT but improved in per-protocol analysis.
A dentifrice containing an ascorbic acid derivative showed reduced gingival redness and higher salivary antioxidant activity; primary GI outcome was not significant in ITT but improved in per-protocol analysis.
Intravenous vitamin C reduced collagen-induced platelet aggregation in both smokers and nonsmokers at early time points.
After varicocele surgery, men given vitamin C had improved sperm movement and shape but not higher sperm counts.
In obese men, alternate-day 1,000 mg vitamin C improved sperm concentration and motility but did not change semen volume or normal morphology.
In patients with metabolic syndrome, intravenous vitamin C quickly improved artery dilation and prevented an exercise/ischemia-related rise in an oxidative stress marker.
In 40 older type II diabetic patients, chronic oral vitamin C (1 g/day) improved oxidative markers and reduced insulin and lipid concentrations.
In 40 older type II diabetic patients, chronic oral vitamin C (1 g/day) improved oxidative markers and reduced insulin and lipid concentrations.
In 99 patients with severe renal failure, thrice-weekly low-dose ascorbate did not improve uraemic symptoms or cardiovascular stability and showed a trend to slightly worse nausea.
In 99 patients with severe renal failure, thrice-weekly low-dose ascorbate did not improve uraemic symptoms or cardiovascular stability and showed a trend to slightly worse nausea.
In 99 patients with severe renal failure, thrice-weekly low-dose ascorbate did not improve uraemic symptoms or cardiovascular stability and showed a trend to slightly worse nausea.
Giving vitamin C and E plus allopurinol around bypass surgery reduced some electrocardiographic ischemic events, perioperative infarctions and enzyme release in certain patient groups.
Giving vitamin C and E plus allopurinol around bypass surgery reduced some electrocardiographic ischemic events, perioperative infarctions and enzyme release in certain patient groups.
Giving vitamin C and E plus allopurinol around bypass surgery reduced some electrocardiographic ischemic events, perioperative infarctions and enzyme release in certain patient groups.
Topical 30% ascorbic acid cleared more basal cell carcinoma lesions at 8 weeks and caused fewer side effects than imiquimod.
Topical 30% ascorbic acid cleared more basal cell carcinoma lesions at 8 weeks and caused fewer side effects than imiquimod.
Supplementation with vitamin C and pantothenic acid showed no major improvement in wound healing; tissue trace-element (including Zn) content correlated with scar mechanical properties in the supplemented group.
Supplementation with vitamin C and pantothenic acid showed no major improvement in wound healing; tissue trace-element (including Zn) content correlated with scar mechanical properties in the supplemented group.
Supplementation with vitamin C and pantothenic acid showed no major improvement in wound healing; tissue trace-element (including Zn) content correlated with scar mechanical properties in the supplemented group.
Five years of vitamin C (500 mg vs 50 mg/day) did not improve overall serum lipid profiles, though high-dose vitamin C may have reduced triglycerides in some women with high baseline levels.
Five years of vitamin C (500 mg vs 50 mg/day) did not improve overall serum lipid profiles, though high-dose vitamin C may have reduced triglycerides in some women with high baseline levels.
Five years of vitamin C (500 mg vs 50 mg/day) did not improve overall serum lipid profiles, though high-dose vitamin C may have reduced triglycerides in some women with high baseline levels.
In 48 men, 500 mg/day slow-release vitamin C raised blood vitamin C but did not reduce markers of lipid peroxidation or DNA oxidation over 36 months.
In 48 men, 500 mg/day slow-release vitamin C raised blood vitamin C but did not reduce markers of lipid peroxidation or DNA oxidation over 36 months.
In 48 men, 500 mg/day slow-release vitamin C raised blood vitamin C but did not reduce markers of lipid peroxidation or DNA oxidation over 36 months.
In 21 septic shock patients, 1.5 g IV vitamin C every 6 hours corrected deficiency and produced high plasma concentrations with a short half-life.
In 160 healthy volunteers, 80–400 mg/day vitamin C for 15 weeks did not increase PBMC vitamin C or reduce oxidative DNA damage.
In 160 healthy volunteers, 80–400 mg/day vitamin C for 15 weeks did not increase PBMC vitamin C or reduce oxidative DNA damage.
In 35 people with type II diabetes, 1.5 g/day oral vitamin C raised plasma levels but did not change oxidative stress marker, blood pressure, or endothelial function after 3 weeks.
In 35 people with type II diabetes, 1.5 g/day oral vitamin C raised plasma levels but did not change oxidative stress marker, blood pressure, or endothelial function after 3 weeks.
In hypertensive men, 8 weeks of vitamins C (1 g/day) + E increased erythrocyte (Na,K)-ATPase activity, improved oxidative stress markers and reduced blood pressure versus placebo.
High‑dose oral vitamin C for 4 weeks eradicated H. pylori in some patients and raised gastric juice vitamin C levels.
High‑dose oral vitamin C for 4 weeks eradicated H. pylori in some patients and raised gastric juice vitamin C levels.
High‑dose oral vitamin C for 4 weeks eradicated H. pylori in some patients and raised gastric juice vitamin C levels.
In patients given 500 mg/day vitamin C, two urate assays yielded similar plasma urate concentrations with only a small non‑significant difference.
Post hoc analysis of a large randomized trial found vitamin C did not alter platelet counts and platelet count changes did not mediate vitamin C–related mortality.
Post hoc analysis of a large randomized trial found vitamin C did not alter platelet counts and platelet count changes did not mediate vitamin C–related mortality.
A 3‑year dietary intervention that increased vitamin C intake was associated with slightly less progression of carotid intima‑media thickness in elderly men.
A 3‑year dietary intervention that increased vitamin C intake was associated with slightly less progression of carotid intima‑media thickness in elderly men.
Slow‑release ascorbic acid produced smaller plasma concentration fluctuations than plain release after 4 weeks in smokers, but clinical significance was small.
Vitamin C (with vitamin E) doubled plasma ascorbic acid and increased mucosal ascorbic acid but did not reduce mucosal reactive oxygen species or malondialdehyde associated with H. pylori infection.
Vitamin C (with vitamin E) doubled plasma ascorbic acid and increased mucosal ascorbic acid but did not reduce mucosal reactive oxygen species or malondialdehyde associated with H. pylori infection.
Oral single-dose vitamin C (2 g) acutely increased radial artery lumen area (vasodilation), with larger effects in smokers and greater increase than diltiazem in preoperative patients.
An oral antioxidant cocktail (including 1000 mg vitamin C) acutely improved flow-mediated brachial artery vasodilation in older adults but reduced it in young adults; reactive hyperemia was unchanged.
An oral antioxidant cocktail (including 1000 mg vitamin C) acutely improved flow-mediated brachial artery vasodilation in older adults but reduced it in young adults; reactive hyperemia was unchanged.
Higher dietary vitamin C was associated with small increases in hip and femoral neck bone density, especially when calcium intake was adequate.
In postmenopausal women, daily antioxidant supplementation including 1000 mg vitamin C prevented the small lumbar spine bone loss seen in the placebo group over 6 months.
Higher dietary vitamin C was associated with small increases in hip and femoral neck bone density, especially when calcium intake was adequate.
Higher dietary vitamin C was associated with small increases in hip and femoral neck bone density, especially when calcium intake was adequate.
In healthy volunteers sensitive to acidic foods, Ester-C caused fewer stomach (epigastric) side effects and was better tolerated than regular ascorbic acid.
In healthy volunteers sensitive to acidic foods, Ester-C caused fewer stomach (epigastric) side effects and was better tolerated than regular ascorbic acid.
In this small RCT of severe acute pancreatitis, daily antioxidant vitamins including 1 g vitamin C did not significantly change organ dysfunction or oxidative stress markers versus standard care.
In patients with early acute pancreatitis, adding antioxidants including vitamin C lowered oxidative stress markers and raised vitamin C, with a non‑significant trend to shorter hospital stay.
In patients with early acute pancreatitis, adding antioxidants including vitamin C lowered oxidative stress markers and raised vitamin C, with a non‑significant trend to shorter hospital stay.
Intravenous vitamin C reduced oxidative stress and, in enalapril-treated moderate CHF patients, augmented the natriuretic effect of furosemide.
In patients with intermittent claudication, vitamin C administration prevented exercise-induced impairment of endothelial function and rises in oxidative stress markers.
In patients with early acute pancreatitis, adding antioxidants including vitamin C lowered oxidative stress markers and raised vitamin C, with a non‑significant trend to shorter hospital stay.
In people with precancerous stomach lesions, short antioxidant regimens raised plasma vitamin C and other plasma antioxidant vitamins but did not increase gastric‑juice vitamin C.
In people with precancerous stomach lesions, short antioxidant regimens raised plasma vitamin C and other plasma antioxidant vitamins but did not increase gastric‑juice vitamin C.
In people with precancerous stomach lesions, short antioxidant regimens raised plasma vitamin C and other plasma antioxidant vitamins but did not increase gastric‑juice vitamin C.
In a double‑blind crossover study, vitamin C supplementation raised plasma ascorbic acid and increased lipid‑standardized alpha‑tocopherol and antioxidant capacity (FRAP), indicating in vivo interactions between vitamins C and E.
In a double‑blind crossover study, vitamin C supplementation raised plasma ascorbic acid and increased lipid‑standardized alpha‑tocopherol and antioxidant capacity (FRAP), indicating in vivo interactions between vitamins C and E.
Grapefruit intake for 2 weeks increased blood vitamin C and reduced gum bleeding in periodontitis patients.
Two-week vitamin C+E supplementation increased plasma vitamins and reduced exercise-induced protein oxidation in trained adults.
IV vitamin C given to iron-overloaded hemodialysis patients improved hematologic markers and reduced erythropoietin requirements.
IV vitamin C given to iron-overloaded hemodialysis patients improved hematologic markers and reduced erythropoietin requirements.
A multicenter randomized trial in smokers found no dose-response effect of oral vitamin C on in vitro mutagen sensitivity.
Randomized study of catheter sealing solutions found vitamin C solution did not prolong central venous catheter patency compared with saline; heparin did prolong patency.
High-dose oral vitamin C (5 g/day for 28 days) did not eradicate H. pylori nor reduce bacterial load in treated patients.
Adding 500 mg daily vitamin C to standard eradication therapy significantly increased H. pylori eradication rates.
Multicenter randomized trial found 1 L PEG with ascorbic acid was non-inferior to sodium picosulfate with magnesium citrate for adequate bowel cleansing and superior for high-quality cleansing, but had slightly lower patient satisfaction.
Multicenter randomized trial found 1 L PEG with ascorbic acid was non-inferior to sodium picosulfate with magnesium citrate for adequate bowel cleansing and superior for high-quality cleansing, but had slightly lower patient satisfaction.
Multicenter randomized trial found 1 L PEG with ascorbic acid was non-inferior to sodium picosulfate with magnesium citrate for adequate bowel cleansing and superior for high-quality cleansing, but had slightly lower patient satisfaction.
Topical THDA combined with acetyl zingerone reduced wrinkles, pigment intensity, and redness more than THDA alone over 8 weeks.
Applying a topical serum containing vitamin C (with vitamin E and ferulic acid) after microneedle RF produced greater wrinkle reduction, higher global improvement ratings, and increased elastin on histology versus placebo.
Topical THDA combined with acetyl zingerone reduced wrinkles, pigment intensity, and redness more than THDA alone over 8 weeks.
Topical THDA combined with acetyl zingerone reduced wrinkles, pigment intensity, and redness more than THDA alone over 8 weeks.
Combined vitamin E and C supplementation reduced LDL oxidation susceptibility in smokers and non-smokers.
Dietary changes (and mate tea) increased vitamin C intake and were associated with higher antioxidant capacity and glutathione in dyslipidemic subjects.
Dietary changes (and mate tea) increased vitamin C intake and were associated with higher antioxidant capacity and glutathione in dyslipidemic subjects.
Combined vitamin C and E increased certain immune cell cytokine outputs more than either vitamin alone in healthy adults.
Combined vitamin C and E increased certain immune cell cytokine outputs more than either vitamin alone in healthy adults.
In CHF patients, an acute IV dose of vitamin C improved baroreceptor sensitivity, but chronic oral vitamin C did not.
High-dose vitamin C (1000 mg twice daily) increased urinary oxalate and stone-risk markers in a subset of participants.
In smokers, daily 1000 mg vitamin C raised blood vitamin C and produced a large (81%) drop in blood lead after one week; 200 mg had no effect on lead.
Blinded randomized tasting study: iodine-based disinfectant (TGHP) worsened water taste, but adding ascorbic acid restored palatability to near plain water.
In young adults, 500 mg vitamin C daily increased plasma antioxidant capacity (ACP) by ~25% at 4 h, ~32% at 24 h, and ~36% after 7 days.
Daily 250 mg vitamin C for six weeks reduced monocyte adhesion in subjects with low baseline vitamin C to levels seen in those with normal levels.
Perioperative supplementation with n-3 PUFAs plus vitamins C and E reduced postoperative atrial fibrillation more in older patients and increased atrial glutathione peroxidase activity in those >60 years.
In young adults, 500 mg vitamin C daily increased plasma antioxidant capacity (ACP) by ~25% at 4 h, ~32% at 24 h, and ~36% after 7 days.
In a double-masked RCT of vitamins C (500 mg) plus E, visual acuity was better at 56 days in the vitamin group, but laser flare (inflammation marker) showed no significant difference over time.
In a double-masked RCT of vitamins C (500 mg) plus E, visual acuity was better at 56 days in the vitamin group, but laser flare (inflammation marker) showed no significant difference over time.
Adults asked to take one vitamin C pill daily for a month showed large self-reported adherence increases in both groups; text reminders correlated with fewer missed pills but between-group difference was not significant.
Adults asked to take one vitamin C pill daily for a month showed large self-reported adherence increases in both groups; text reminders correlated with fewer missed pills but between-group difference was not significant.
In a 12-week double-blind RCT of combined antioxidant doses including vitamin C, high-dose antioxidants markedly increased LDL oxidation lag phase (reduced LDL susceptibility to oxidation) with a dose-response effect.
Randomized blind clinical study in preschool children testing water fortification with iron+ascorbic acid, ascorbic acid alone, or plain water over 3 months; hemoglobin rose in all groups, MCV improved with iron+ascorbic and with ascorbic alone, ferritin increased only with iron+ascorbic.
Hemodialysis patients receiving 300 mg IV vitamin C each session for 3 months showed improved hemoglobin and transferrin saturation and reduced reticulocyte hemoglobin content and serum ferritin compared with standard care.
Daily baobab fruit pulp (rich in vitamin C) given with a school meal for 83 days produced a small increase in hemoglobin and smaller declines in ferritin versus control, but differences were not statistically significant.
In hemodialysis patients with refractory anemia, intravenous vitamin C (300 mg each dialysis) improved hemoglobin and iron availability and reduced inflammation markers over 6 months.
Vitamin C 500 mg/day for 4 weeks increased brachial flow-mediated dilation but did not change lipids or inflammatory markers.
Vitamin C 500 mg/day for 4 weeks increased brachial flow-mediated dilation but did not change lipids or inflammatory markers.
Daily 1 g vitamin C + 1 g vitamin E for 2 months markedly reduced sperm DNA fragmentation in men with elevated baseline levels.
Daily 1 g vitamin C + 1 g vitamin E for 2 months markedly reduced sperm DNA fragmentation in men with elevated baseline levels.
Ascorbic acid 250 mg/day for 6 weeks improved peak expiratory flow in adults ≥35 years, while most other lung measures were unchanged.
Ascorbic acid 250 mg/day for 6 weeks improved peak expiratory flow in adults ≥35 years, while most other lung measures were unchanged.
Ascorbic acid 250 mg/day for 6 weeks improved peak expiratory flow in adults ≥35 years, while most other lung measures were unchanged.
Three-month moderate-dose vitamin supplementation (including 272 mg vitamin C) repleted plasma ascorbic acid in smokers and raised plasma vitamin E markers.
Three-month moderate-dose vitamin supplementation (including 272 mg vitamin C) repleted plasma ascorbic acid in smokers and raised plasma vitamin E markers.
In septic shock patients, IV antioxidant therapy including vitamin C raised vitamin C levels and improved some hemodynamic measures.
In septic shock patients, IV antioxidant therapy including vitamin C raised vitamin C levels and improved some hemodynamic measures.
Daily 250 mg vitamin C for six weeks reduced monocyte adhesion in subjects with low baseline vitamin C to levels seen in those with normal levels.
Local vaginal application of 250 mg vitamin C devices lowered and maintained vaginal pH in women with high baseline pH.
Local vaginal application of 250 mg vitamin C devices lowered and maintained vaginal pH in women with high baseline pH.
High-dose IV ascorbic acid during the first 24 hours after major burns reduced fluid needs, edema/weight gain, and duration of mechanical ventilation.
High-dose IV ascorbic acid during the first 24 hours after major burns reduced fluid needs, edema/weight gain, and duration of mechanical ventilation.
In male physicians, vitamin C supplement use was not associated with a reduced risk of age-related maculopathy.
Oral vitamin C increased blood levels and dose-dependently reduced urinary nicotine metabolite excretion in smokers.
High-dose vitamin C (4.5 g/day) did not significantly lower plasma Lp(a) in patients with premature coronary heart disease.
Oral vitamin C increased plasma and urinary ascorbate in a dose-dependent manner; nasal lavage (RTLF) ascorbate showed an acute rise after a high (1000 mg) dose peaking at 2–4 h but returned to baseline by 24 h.
Oral vitamin C increased plasma and urinary ascorbate in a dose-dependent manner; nasal lavage (RTLF) ascorbate showed an acute rise after a high (1000 mg) dose peaking at 2–4 h but returned to baseline by 24 h.
Patients with chronic bacterial prostatitis had lower plasma vitamin C and antioxidant enzymes and higher oxidative-damage markers than healthy controls.
Perioperative supplementation with n-3 PUFAs plus vitamins C and E reduced postoperative atrial fibrillation more in older patients and increased atrial glutathione peroxidase activity in those >60 years.
Supplementation with n‑3 PUFAs plus vitamins C (1 g/day) and E reduced post‑operative atrial fibrillation and increased cardiac antioxidant enzyme activity.
Adding oral vitamin C around surgery greatly reduced postoperative atrial fibrillation compared with controls on beta-blockers alone.
Perioperative oral ascorbic acid did not significantly reduce the incidence or timing of postoperative atrial fibrillation after on-pump CABG.
Randomized, triple‑blind trial of perioperative ascorbic acid vs placebo in CABG patients; monitored postoperative atrial fibrillation and complications.
Perioperative vitamin C supplementation reduced incidence of postoperative atrial fibrillation and shortened hospital and ICU stays compared with control.
Perioperative oral ascorbic acid did not significantly reduce the incidence or timing of postoperative atrial fibrillation after on-pump CABG.
Isoflavone supplementation reduced homocysteine and some resting oxidative markers but did not change plasma vitamin C or prevent exercise-induced oxidative stress.
In smoking men, 2-month ascorbic acid (500 mg/day) raised plasma vitamin C but did not improve lipoprotein oxidation resistance and plain ascorbate was associated with increased MDA.
Women with endometriosis taking combined vitamins C and E had lower oxidative stress markers over months, but pregnancy rates did not improve.
Daily antioxidant supplement (included ascorbic acid) given to children, young and elderly improved oxidative markers and erythrocyte membrane fluidity in young/elderly but not children.
In women using oral contraceptives, combined low-dose vitamin C and E supplementation decreased lipid peroxidation (MDA) and increased GPx and GR activities.
Bowel prep containing ascorbic acid (PEGA) produced high satisfactory cleansing rates, especially with split-dose; tolerability was similar across groups.
Bowel prep containing ascorbic acid (PEGA) produced high satisfactory cleansing rates, especially with split-dose; tolerability was similar across groups.
Bowel prep containing ascorbic acid (PEGA) produced high satisfactory cleansing rates, especially with split-dose; tolerability was similar across groups.
Topical 10% L-ascorbic acid plus phytic acid serum lightened solar lentigines more than vehicle and was generally well tolerated.
Topical 10% L-ascorbic acid plus phytic acid serum lightened solar lentigines more than vehicle and was generally well tolerated.
Non-hospitalized adults with COVID-19/covid-like illness received melatonin, zinc and multivitamins (including vitamin D) or placebo; the supplement arm had faster symptom resolution by days 5 and 10.
Topical 10% L-ascorbic acid plus phytic acid serum lightened solar lentigines more than vehicle and was generally well tolerated.
2-L PEG with ascorbic acid and sodium picosulfate/magnesium citrate had similar overall cleansing; the SP/MC regimen had better tolerability and fewer adverse events.
Pre-exercise oral ascorbic acid acutely reduced postexercise MDA but over 3 months supplementation produced no consistent changes in oxidative stress markers or metabolic profile.
Pre-exercise oral ascorbic acid acutely reduced postexercise MDA but over 3 months supplementation produced no consistent changes in oxidative stress markers or metabolic profile.
Cross‑sectional study found vegetarians had higher plasma antioxidant status and higher plasma vitamin C (statistically significant) and lower LDL TBARS compared with nonvegetarians.
Pre-exercise oral ascorbic acid acutely reduced postexercise MDA but over 3 months supplementation produced no consistent changes in oxidative stress markers or metabolic profile.
High-dose oral vitamin C during the luteal phase did not improve clinical pregnancy or implantation rates in women undergoing IVF.
High-dose oral vitamin C during the luteal phase did not improve clinical pregnancy or implantation rates in women undergoing IVF.
High-dose oral vitamin C during the luteal phase did not improve clinical pregnancy or implantation rates in women undergoing IVF.
Large randomized trial testing simvastatin and antioxidant vitamin supplementation (including vitamin C) in high-risk patients; early results showed good tolerability and biochemical changes but no specific vitamin C outcomes reported in this early report.
High-dose vitamin C for 4 weeks did not change kidney filtration measures in male type 1 diabetes patients.
High-dose vitamin C for 4 weeks did not change kidney filtration measures in male type 1 diabetes patients.
High-dose vitamin C for 4 weeks did not change kidney filtration measures in male type 1 diabetes patients.
Topical ascorbic acid (AS-G gel) lightened gingival melanin pigmentation versus placebo over 12 weeks.
Ascorbic acid status/IV treatment was associated with lower soluble transferrin receptor levels and higher transferrin saturation in hemodialysis patients.
Ascorbic acid status/IV treatment was associated with lower soluble transferrin receptor levels and higher transferrin saturation in hemodialysis patients.
In hemodialysis patients with refractory anemia, intravenous vitamin C (300 mg each dialysis) improved hemoglobin and iron availability and reduced inflammation markers over 6 months.
In 62 CKD patients randomized to three oral iron therapies, the group receiving ferric sodium EDTA combined with vitamin C and other micronutrients showed larger improvements in hemoglobin and iron parameters and reductions in inflammatory markers.
Daily supplementation with vitamin C, vitamin E and selenium did not reduce cisplatin-induced nephrotoxicity or ototoxicity overall, though higher plasma antioxidant levels correlated with less high-tone hearing loss.
Daily supplementation with vitamin C, vitamin E and selenium did not reduce cisplatin-induced nephrotoxicity or ototoxicity overall, though higher plasma antioxidant levels correlated with less high-tone hearing loss.
In children undergoing outpatient pin removal, acetaminophen or ibuprofen did not reduce pain compared with placebo (vitamin C used as placebo).
In healthy volunteers, single short GTN protected endothelium from I/R injury but protection was lost with prolonged GTN; intra-arterial vitamin C restored acetylcholine-mediated endothelial responses and prevented loss of preconditioning.
In healthy volunteers, single short GTN protected endothelium from I/R injury but protection was lost with prolonged GTN; intra-arterial vitamin C restored acetylcholine-mediated endothelial responses and prevented loss of preconditioning.
Long-term micronutrient supplementation (capsules including 250 mg vitamin C plus vitamin E and selenium) was associated with small increases in total and LDL cholesterol after ~7.3 years.
In a 75-day randomized double-blind trial, vitamin C (and vitamin E) reduced total and LDL cholesterol and raised HDL in healthy adults aged 50+; vitamin C group showed no significant triglyceride change.
In type 2 diabetic patients, combined mineral (Mg+Zn) plus vitamins C+E increased HDL cholesterol and apolipoprotein A1 over 3 months; Mg+Zn alone showed no significant changes.
An 8-month randomized double-blind placebo-controlled trial (n=138 completers) found no overall effect of 1 g/day vitamin C on HDL, LDL, total cholesterol or triglycerides; a small subgroup (n=43, low baseline AA) showed HDL +0.10 mmol/L.
A 3-month trial of a polyphenol-rich antioxidant supplement (pomegranate, green tea extracts, plus ascorbic acid) in type 2 diabetics lowered LDL and MDA and increased antioxidant markers compared with placebo.
Smokers who believed they took a dietary supplement smoked more and felt more invulnerable; positive attitudes toward supplements increased this effect.
Smokers who believed they took a dietary supplement smoked more and felt more invulnerable; positive attitudes toward supplements increased this effect.
Smokers who believed they took a dietary supplement smoked more and felt more invulnerable; positive attitudes toward supplements increased this effect.
ESRD patients randomized to 1,000 mg/day vitamin C showed no significant differences versus placebo on lipid profile or lipoprotein oxidation after one year.
A vitamin C (ascorbic acid) microneedle patch reduced crow's-feet wrinkle measures versus control without causing irritation or sensitization.
A vitamin C (ascorbic acid) microneedle patch reduced crow's-feet wrinkle measures versus control without causing irritation or sensitization.
Oral ascorbic acid increased ASC concentrations in gastric mucosa, plasma and urine; acetylsalicylic acid (ASA) alone decreased ASC, reducing gastric mucosa ASC by ~10% in 6 days.
Oral ascorbic acid increased ASC concentrations in gastric mucosa, plasma and urine; acetylsalicylic acid (ASA) alone decreased ASC, reducing gastric mucosa ASC by ~10% in 6 days.
In patients with acute MI, 14-day treatment with vitamins C and E reduced exercise-induced QT dispersion compared with placebo.
A short controlled intervention with vitamin C–rich nectar in men with low baseline levels substantially increased the proportion exceeding a threshold plasma ascorbic acid concentration.
A short controlled intervention with vitamin C–rich nectar in men with low baseline levels substantially increased the proportion exceeding a threshold plasma ascorbic acid concentration.
In patients with chronic renal impairment undergoing coronary angiography, ascorbic acid did not reduce the incidence of contrast-induced nephropathy versus placebo.
Adding oral vitamin C to bicarbonate hydration did not significantly reduce contrast-induced kidney injury compared with bicarbonate alone.
Dietary vitamin C enrichment (500 mg/day) in young men increased plasma ascorbic acid and reduced the susceptibility of lipoproteins to oxidation.
In adults with acute bronchitis, low‑dose vitamin C was as effective as azithromycin—no meaningful difference in quality of life or return to activities at day 7.
In adults with acute bronchitis, low‑dose vitamin C was as effective as azithromycin—no meaningful difference in quality of life or return to activities at day 7.
In adults with acute bronchitis, low‑dose vitamin C was as effective as azithromycin—no meaningful difference in quality of life or return to activities at day 7.
In 131 patients with septic shock randomized to antioxidant arms, vitamin C treatment (oral 1 g q6h for 5 days) was associated with marked SOFA score improvement and reductions in some oxidative stress markers and inflammatory cytokines.
In septic shock patients, oral vitamin C (small group) restored vitamin C levels and improved organ dysfunction and some inflammation/oxidative markers.
In septic shock patients, vitamin C (1 g q6h) as part of antioxidant therapy reduced organ dysfunction (SOFA) and lowered inflammatory/oxidative markers.
In septic shock patients, oral vitamin C (small group) restored vitamin C levels and improved organ dysfunction and some inflammation/oxidative markers.
Long-term daily vitamin C (500 mg) did not reduce major cardiovascular events or mortality in middle-aged and older men.
Long-term daily vitamin C (500 mg) did not reduce major cardiovascular events or mortality in middle-aged and older men.
Long-term daily vitamin C (500 mg) did not reduce major cardiovascular events or mortality in middle-aged and older men.
A randomized dietary trial showed the Mediterranean-type diet group had fewer deaths and cancers over 4 years; plasma vitamin C levels increased in the diet group, but the effect cannot be attributed solely to vitamin C.
Older women with sarcopenia did 12 weeks of resistance training with either vitamins C+E or placebo; supplementation improved some muscle mass and strength gains and improved antioxidant markers versus placebo.
Older women with sarcopenia did 12 weeks of resistance training with either vitamins C+E or placebo; supplementation improved some muscle mass and strength gains and improved antioxidant markers versus placebo.
Older women with sarcopenia did 12 weeks of resistance training with either vitamins C+E or placebo; supplementation improved some muscle mass and strength gains and improved antioxidant markers versus placebo.
Adults with CMT1A were randomized to 0, 1 g, or 3 g/day ascorbic acid for 12 months; no significant benefit on neuropathy score was observed and treatment was well tolerated.
Runners taking 1000 mg vitamin C + 300 mg vitamin E for 6 weeks showed prevention of exercise-induced lipid peroxidation but still exhibited marked inflammatory marker rises after a 50 km race.
Runners taking 1000 mg vitamin C + 300 mg vitamin E for 6 weeks showed prevention of exercise-induced lipid peroxidation but still exhibited marked inflammatory marker rises after a 50 km race.
Giving 1,000 mg oral vitamin C before surgery did not prevent the postoperative drop in plasma ascorbic acid on day 1.
Adding 500 mg vitamin C to a one-week clarithromycin-based triple therapy increased H. pylori eradication rates for clarithromycin-susceptible strains compared with standard-dose clarithromycin.
Giving vitamin C with vitamin E soon after stroke increased antioxidant capacity and reduced markers of lipid oxidation and inflammation.
Antioxidant vitamins, with or without B-group vitamins (including B12), improved antioxidant capacity, lowered oxidative damage markers and reduced CRP after acute ischemic stroke; B vitamins reduced homocysteine.
Giving vitamin C with vitamin E soon after stroke increased antioxidant capacity and reduced markers of lipid oxidation and inflammation.
Giving vitamin C with vitamin E soon after stroke increased antioxidant capacity and reduced markers of lipid oxidation and inflammation.
Adding high‑dose IV vitamin C to docetaxel did not improve PSA responses or progression outcomes and showed trends toward more toxicity.
Adding high‑dose IV vitamin C to docetaxel did not improve PSA responses or progression outcomes and showed trends toward more toxicity.
Adding high‑dose IV vitamin C to docetaxel did not improve PSA responses or progression outcomes and showed trends toward more toxicity.
Preoperative oral vitamin C (500 mg twice daily for 7 days) prevented etomidate-induced cortisol suppression and reduced inotrope (adrenaline) requirement.
Preoperative oral vitamin C (500 mg twice daily for 7 days) prevented etomidate-induced cortisol suppression and reduced inotrope (adrenaline) requirement.
Preoperative oral vitamin C (500 mg twice daily for 7 days) prevented etomidate-induced cortisol suppression and reduced inotrope (adrenaline) requirement.
Daily vitamin C (1000 mg) plus vitamin E (800 IU) for 8 weeks reduced oxidative stress markers and improved pain scores in women with endometriosis versus placebo.
Daily vitamin C (1000 mg) plus vitamin E (800 IU) for 8 weeks reduced oxidative stress markers and improved pain scores in women with endometriosis versus placebo.
After varicocele surgery, men given vitamin C had improved sperm movement and shape but not higher sperm counts.
After varicocele surgery, men given vitamin C had improved sperm movement and shape but not higher sperm counts.
In older women at risk for cardiovascular disease, vitamin C did not slow cognitive decline over ~5 years though a small better score at the final assessment was observed.
In older women at risk for cardiovascular disease, vitamin C did not slow cognitive decline over ~5 years though a small better score at the final assessment was observed.
Perioperative IV vitamin C reduced reported postoperative pain and analgesic use after hip fracture surgery.
Peri- and postoperative vitamin C reduced subjective pain and analgesic use after hip fracture surgery but did not change hip function scores.
Perioperative IV vitamin C reduced reported postoperative pain and analgesic use after hip fracture surgery.
Perioperative IV vitamin C reduced reported postoperative pain and analgesic use after hip fracture surgery.
In hemodialysis patients, intravenous vitamin C (with or without a vitamin E–coated dialyzer) reduced dialysis-related oxidative stress and preserved red blood cell reducing activity.
In hemodialysis patients, intravenous vitamin C (with or without a vitamin E–coated dialyzer) reduced dialysis-related oxidative stress and preserved red blood cell reducing activity.
In hemodialysis patients, intravenous vitamin C (with or without a vitamin E–coated dialyzer) reduced dialysis-related oxidative stress and preserved red blood cell reducing activity.
In smoking men, 2-month ascorbic acid (500 mg/day) raised plasma vitamin C but did not improve lipoprotein oxidation resistance and plain ascorbate was associated with increased MDA.
In smoking men, 2-month ascorbic acid (500 mg/day) raised plasma vitamin C but did not improve lipoprotein oxidation resistance and plain ascorbate was associated with increased MDA.
Women with endometriosis taking combined vitamins C and E had lower oxidative stress markers over months, but pregnancy rates did not improve.
Women with endometriosis taking combined vitamins C and E had lower oxidative stress markers over months, but pregnancy rates did not improve.
Oral vitamin C prevented development of nitrate tolerance: it preserved nitroglycerin-induced vasodilation and platelet cGMP after continuous nitrate exposure.
Oral vitamin C prevented development of nitrate tolerance: it preserved nitroglycerin-induced vasodilation and platelet cGMP after continuous nitrate exposure.
Oral vitamin C prevented development of nitrate tolerance: it preserved nitroglycerin-induced vasodilation and platelet cGMP after continuous nitrate exposure.
Daily 500 mg vitamin C did not increase lesion regression and was associated with a non-significant tendency toward higher progression; combined vitamin C + beta‑carotene showed a possible increased progression signal.
Daily 500 mg vitamin C did not increase lesion regression and was associated with a non-significant tendency toward higher progression; combined vitamin C + beta‑carotene showed a possible increased progression signal.
Daily 500 mg vitamin C did not increase lesion regression and was associated with a non-significant tendency toward higher progression; combined vitamin C + beta‑carotene showed a possible increased progression signal.
Short‑term combined vitamins C (1 g) and E (400 IU) improved endothelial function and reduced arterial stiffness in untreated hypertensive men.
Short‑term combined vitamins C (1 g) and E (400 IU) improved endothelial function and reduced arterial stiffness in untreated hypertensive men.
Short‑term combined vitamins C (1 g) and E (400 IU) improved endothelial function and reduced arterial stiffness in untreated hypertensive men.
Giving 25 mg vitamin C twice daily as limeade raised plasma vitamin C but did not improve hemoglobin or other iron status markers in iron‑deficient women consuming high‑phytate diets.
Pilot RCT found feasibility for a larger trial; per‑protocol analysis suggested lower opioid use with vitamin C, but intention‑to‑treat results were inconsistent and the study was underpowered.
Pilot RCT found feasibility for a larger trial; per‑protocol analysis suggested lower opioid use with vitamin C, but intention‑to‑treat results were inconsistent and the study was underpowered.
Pilot RCT found feasibility for a larger trial; per‑protocol analysis suggested lower opioid use with vitamin C, but intention‑to‑treat results were inconsistent and the study was underpowered.
Vitamin C given after distal radius fracture did not improve finger range of motion, arm function, or pain at 6 weeks or 6 months.
Randomized blind clinical study in preschool children testing water fortification with iron+ascorbic acid, ascorbic acid alone, or plain water over 3 months; hemoglobin rose in all groups, MCV improved with iron+ascorbic and with ascorbic alone, ferritin increased only with iron+ascorbic.
In children with iron‑deficiency anemia, ferrous ascorbate produced larger and faster improvements in hemoglobin and other hematologic indices over 3 months compared with iron polymaltose complex.
In children with iron‑deficiency anemia, ferrous ascorbate produced larger and faster improvements in hemoglobin and other hematologic indices over 3 months compared with iron polymaltose complex.
12‑week quercetin supplementation given with modest doses of vitamin C and niacin produced negligible effects on most disease risk factors in community adults.
12‑week quercetin supplementation given with modest doses of vitamin C and niacin produced negligible effects on most disease risk factors in community adults.
12‑week quercetin supplementation given with modest doses of vitamin C and niacin produced negligible effects on most disease risk factors in community adults.
Giving vitamins C and E after PPROM was associated with a longer time from membrane rupture to delivery.
Vitamin C given after distal radius fracture did not improve finger range of motion, arm function, or pain at 6 weeks or 6 months.
Vitamin C given after distal radius fracture did not improve finger range of motion, arm function, or pain at 6 weeks or 6 months.
Vitamin C altered cold-pressor–induced myocardial blood flow (MBF) responses heterogeneously: improved MBF in smokers (short- and long-term) and in hypertensives after long-term treatment, but not in hypercholesterolemic patients.
Vitamin C altered cold-pressor–induced myocardial blood flow (MBF) responses heterogeneously: improved MBF in smokers (short- and long-term) and in hypertensives after long-term treatment, but not in hypercholesterolemic patients.
Vitamin C altered cold-pressor–induced myocardial blood flow (MBF) responses heterogeneously: improved MBF in smokers (short- and long-term) and in hypertensives after long-term treatment, but not in hypercholesterolemic patients.
Short-term supplementation with vitamin C/E during radiotherapy reduced patient-reported dry mouth and improved oral indices at early follow-up compared with placebo.
Short-term supplementation with vitamin C/E during radiotherapy reduced patient-reported dry mouth and improved oral indices at early follow-up compared with placebo.
Short-term supplementation with vitamin C/E during radiotherapy reduced patient-reported dry mouth and improved oral indices at early follow-up compared with placebo.
Randomized clinical trial in off-pump CABG patients found perioperative oral vitamin C (with other arms) did not reduce incidence or severity of acute kidney injury or related morbidity.
In sepsis patients, adding vitamin C + thiamine + hydrocortisone did not change mortality but reduced vasopressor duration and increased lactate clearance.
In sepsis patients, adding vitamin C + thiamine + hydrocortisone did not change mortality but reduced vasopressor duration and increased lactate clearance.
Large randomized, blinded trial gave IV antioxidants (3 g vitamin C + NAC) perioperatively and found no reduction in postoperative myocardial injury compared with placebo.
In adults with septic shock, combination therapy including ascorbic acid did not significantly reduce organ failure (SOFA score), kidney failure, or 30-day mortality versus placebo.
In 501 critically ill sepsis patients, IV vitamin C plus thiamine and hydrocortisone did not increase ventilator- and vasopressor-free days or reduce 30-day mortality compared with placebo.
In sepsis patients, adding vitamin C + thiamine + hydrocortisone did not change mortality but reduced vasopressor duration and increased lactate clearance.
In sepsis patients, adding vitamin C + thiamine + hydrocortisone did not change mortality but reduced vasopressor duration and increased lactate clearance.
Single 1000 mg dose of ascorbic acid produced no overall anxiolytic effect, but reduced state-anxiety in a high trait‑anxiety subgroup.
Single 1000 mg dose of ascorbic acid produced no overall anxiolytic effect, but reduced state-anxiety in a high trait‑anxiety subgroup.
Ascorbic acid given around coronary procedures reduced contrast-induced acute kidney injury (CI-AKI), significantly so with the iso-osmolar agent.
Intravenous ascorbic acid (500 mg twice before procedure) did not significantly prevent contrast-induced acute kidney injury compared with placebo.
Intravenous ascorbic acid (500 mg twice before procedure) did not significantly prevent contrast-induced acute kidney injury compared with placebo.
Supplementation with vitamin C (500 mg) + vitamin E (100 mg) attenuated ozone-induced acute declines in FEV1 and FVC in cyclists.
Supplementation with vitamin C (500 mg) + vitamin E (100 mg) attenuated ozone-induced acute declines in FEV1 and FVC in cyclists.
In septic shock patients, vitamin C (1 g q6h) as part of antioxidant therapy reduced organ dysfunction (SOFA) and lowered inflammatory/oxidative markers.
In septic shock patients, vitamin C (1 g q6h) as part of antioxidant therapy reduced organ dysfunction (SOFA) and lowered inflammatory/oxidative markers.
In hemodialysis patients, giving 250 mg vitamin C three times weekly for 8 weeks lowered serum uric acid but did not change creatinine.
Statin plus ascorbic acid reduced the incidence of post-contrast acute kidney injury compared to placebo, though serum creatinine and eGFR changes were not improved between groups.
In CHF patients, 4 g/day vitamin C for 4 weeks improved endothelial function but increased markers of skeletal muscle metabolic stress during exercise.
In CHF patients, 4 g/day vitamin C for 4 weeks improved endothelial function but increased markers of skeletal muscle metabolic stress during exercise.
In CHF patients, 4 g/day vitamin C for 4 weeks improved endothelial function but increased markers of skeletal muscle metabolic stress during exercise.
In type 2 diabetics, combined minerals + vitamins (including Mg+Zn) for 3 months lowered systolic, diastolic and mean blood pressure; Mg+Zn alone did not.
In type 2 diabetics, combined minerals + vitamins (including Mg+Zn) for 3 months lowered systolic, diastolic and mean blood pressure; Mg+Zn alone did not.
In type 2 diabetics, combined minerals + vitamins (including Mg+Zn) for 3 months lowered systolic, diastolic and mean blood pressure; Mg+Zn alone did not.
In type 2 diabetics, combined minerals + vitamins (including Mg+Zn) for 3 months lowered systolic, diastolic and mean blood pressure; Mg+Zn alone did not.
Vitamin C taken orally or applied locally helped soft tissue healing (reduced socket depth) after tooth extraction by day 21 but did not change bone formation on x-rays.
Vitamin C taken orally or applied locally helped soft tissue healing (reduced socket depth) after tooth extraction by day 21 but did not change bone formation on x-rays.
Ascorbic acid-containing microneedle patches applied twice daily reduced crow's-feet wrinkle measures over 12 weeks with no reported side effects.
Ascorbic acid-containing microneedle patches applied twice daily reduced crow's-feet wrinkle measures over 12 weeks with no reported side effects.
Ascorbic acid-containing microneedle patches applied twice daily reduced crow's-feet wrinkle measures over 12 weeks with no reported side effects.
Adding vitamin C to simvastatin did not provide lipid-profile benefits beyond simvastatin alone in patients with low HDL-C.
Drinking 500 mL/day orange juice while doing aerobic training for 3 months was associated with better cholesterol and less muscle fatigue.
High-dose vitamin C plus E did not reduce the rate of preeclampsia in women at increased risk in this large randomized trial.
High-dose vitamin C plus E did not reduce the rate of preeclampsia in women at increased risk in this large randomized trial.
In patients with metabolic syndrome, intravenous vitamin C quickly improved artery dilation and prevented an exercise/ischemia-related rise in an oxidative stress marker.
In patients with metabolic syndrome, intravenous vitamin C quickly improved artery dilation and prevented an exercise/ischemia-related rise in an oxidative stress marker.
A 6-month antioxidant regimen including vitamin C raised blood antioxidant levels but did not change liver enzymes or hepatitis C viral load.
A 6-month antioxidant regimen including vitamin C raised blood antioxidant levels but did not change liver enzymes or hepatitis C viral load.
Large randomized trial testing simvastatin and antioxidant vitamin supplementation (including vitamin C) in high-risk patients; early results showed good tolerability and biochemical changes but no specific vitamin C outcomes reported in this early report.
Topical serum containing a vitamin C derivative applied daily showed improved wrinkles, firmness and reduced redness over 12 weeks.
Topical serum containing a vitamin C derivative applied daily showed improved wrinkles, firmness and reduced redness over 12 weeks.
Topical serum containing a vitamin C derivative applied daily showed improved wrinkles, firmness and reduced redness over 12 weeks.
Breast-cancer patients given vitamin C plus E during chemotherapy showed improved antioxidant markers and reduced lipid peroxidation and DNA damage compared with chemotherapy alone.
Breast-cancer patients given vitamin C plus E during chemotherapy showed improved antioxidant markers and reduced lipid peroxidation and DNA damage compared with chemotherapy alone.
Breast-cancer patients given vitamin C plus E during chemotherapy showed improved antioxidant markers and reduced lipid peroxidation and DNA damage compared with chemotherapy alone.
Perioperative oral vitamin C prevented postoperative plasma vitamin C depletion and was associated with a lower (non-significant) rate of arthrofibrosis after knee replacement.
Perioperative oral vitamin C prevented postoperative plasma vitamin C depletion and was associated with a lower (non-significant) rate of arthrofibrosis after knee replacement.
Perioperative oral vitamin C prevented postoperative plasma vitamin C depletion and was associated with a lower (non-significant) rate of arthrofibrosis after knee replacement.
Fortified porridge given for 6 months raised hemoglobin and ferritin and improved motor development in infants.
Two months of multi-micronutrient Sprinkles (including vitamin C) reduced anemia and increased hemoglobin in 9–24 month old children.
In this cohort, nonanemic children had higher vitamin C intake than anemic children, suggesting an association between vitamin C intake and lower anemia prevalence.
Six months of providing drinking-water with ascorbic acid (with or without iron) in daycare centers reduced anemia prevalence and increased mean hemoglobin and height gain in preschool children.
A 6-month school feeding intervention with cowpea-based food plus a vitamin C-rich drink increased hemoglobin and reduced anemia prevalence in children.
Daily mungbean meal with guava (high vitamin C) for 7 months increased hemoglobin and reduced anemia prevalence but did not increase body iron stores.
Six months of providing drinking-water with ascorbic acid (with or without iron) in daycare centers reduced anemia prevalence and increased mean hemoglobin and height gain in preschool children.
Critically ill patients receiving enteral formula enriched with vitamins A, C, and E showed increased plasma antioxidant vitamins and improved LDL resistance to oxidation, with no change in clinical outcomes.
Brief behavioural counselling increased fruit and vegetable intake versus nutrition education; plasma beta-carotene and alpha-tocopherol rose but plasma ascorbic acid (vitamin C) did not change.
After 2 years of daily antioxidant supplementation (including 120 mg vitamin C), plasma concentrations of vitamin C, vitamin E, beta-carotene, selenium and zinc were significantly higher than placebo in a 1000-person subsample.
High-dose vitamin C (4 g/day) did not produce clear clinical benefit vs placebo over 2 years for neuropathy in CMT1A patients.
High-dose vitamin C (4 g/day) did not produce clear clinical benefit vs placebo over 2 years for neuropathy in CMT1A patients.
High-dose vitamin C (4 g/day) did not produce clear clinical benefit vs placebo over 2 years for neuropathy in CMT1A patients.
In smoker blood-donors, vitamin C supplementation increased folate measures but unexpectedly increased homocysteine levels when given alone.
In smoker blood-donors, vitamin C supplementation increased folate measures but unexpectedly increased homocysteine levels when given alone.
In smoker blood-donors, vitamin C supplementation increased folate measures but unexpectedly increased homocysteine levels when given alone.
High-dose vitamins C+E during 12 weeks of strength training reduced gains in some muscle mass measures compared with placebo in elderly men.
High-dose vitamins C+E during 12 weeks of strength training reduced gains in some muscle mass measures compared with placebo in elderly men.
High-dose vitamins C+E during 12 weeks of strength training reduced gains in some muscle mass measures compared with placebo in elderly men.
Long-term supplementation with antioxidants and zinc+copper had no detectable benefit or harm on cognition in older adults.
Small preliminary randomized, placebo-controlled trial of topical QR-333 (combination including vitamin D3) reported symptom improvements in diabetic neuropathy but attribution to vitamin D is unclear.
A 2-L PEG solution with added vitamin C cleaned the bowel about as well as the standard 4-L solution, was better accepted by patients, and showed no unsafe lab values though one MI occurred.
A 2-L PEG solution with added vitamin C cleaned the bowel about as well as the standard 4-L solution, was better accepted by patients, and showed no unsafe lab values though one MI occurred.
A 2-L PEG solution with added vitamin C cleaned the bowel about as well as the standard 4-L solution, was better accepted by patients, and showed no unsafe lab values though one MI occurred.
In a 30-day supplementation trial, vitamin E reduced urine lipid peroxidation products, while the supplied text does not report a clear effect for the 1 g/day vitamin C arm.
Daily 1 g vitamin C for 8 weeks reduced inflammatory markers (hs-CRP, IL-6) and fasting blood glucose in hypertensive and/or diabetic obese adults versus control.
Daily 1 g vitamin C for 8 weeks reduced inflammatory markers (hs-CRP, IL-6) and fasting blood glucose in hypertensive and/or diabetic obese adults versus control.
In patients with sepsis and ARDS, a 96-hour IV vitamin C infusion did not significantly change organ dysfunction scores or biomarkers of inflammation/vascular injury compared with placebo.
In patients with sepsis and ARDS, a 96-hour IV vitamin C infusion did not significantly change organ dysfunction scores or biomarkers of inflammation/vascular injury compared with placebo.
In patients with sepsis and ARDS, a 96-hour IV vitamin C infusion did not significantly change organ dysfunction scores or biomarkers of inflammation/vascular injury compared with placebo.
In women with iron deficiency, the multi-nutrient supplement (contains vitamin C) increased blood iron markers after 60 days.
In women with iron deficiency, the multi-nutrient supplement (contains vitamin C) increased blood iron markers after 60 days.
Provision of 1 g/day vitamin C around foot/ankle surgery was associated with a large reduction in CRPS I incidence compared with the historical control period.
Daily 1000 mg vitamin C from mid-pregnancy until delivery did not significantly reduce pre-eclampsia or major neonatal adverse outcomes.
Large randomized trial in pregnant women with type 1 diabetes: vitamins C+E increased blood vitamin levels but did not reduce pre-eclampsia or gestational hypertension overall.
Combined high-dose vitamin E and 1000 mg vitamin C for 3 months reduced markers of oxidative stress and showed a non-significant trend toward lower viral load.
Combined high-dose vitamin E and 1000 mg vitamin C for 3 months reduced markers of oxidative stress and showed a non-significant trend toward lower viral load.
In obese children, 45-day 500 mg/day vitamin C supplementation lowered mean blood pressure and restored peripheral vasodilation during mental stress.
In obese children, 45-day 500 mg/day vitamin C supplementation lowered mean blood pressure and restored peripheral vasodilation during mental stress.
In septic shock patients, IV vitamin C raised blood vitamin C levels but did not reduce an oxidative stress biomarker (8‑isoprostane).
In 324 anemic adolescent girls, once- or twice-weekly multiple micronutrient supplements (including vitamin C) improved vitamin C status and several other micronutrients compared with iron+folic acid over 52 weeks; hemoglobin differences were minimal overall.
In septic shock patients, IV vitamin C raised blood vitamin C levels but did not reduce an oxidative stress biomarker (8‑isoprostane).
In elderly subjects, combined vitamin C+E (with varying beta‑carotene) improved red blood cell resistance to oxidative hemolysis and membrane function.
In elderly subjects, combined vitamin C+E (with varying beta‑carotene) improved red blood cell resistance to oxidative hemolysis and membrane function.
In elderly subjects, combined vitamin C+E (with varying beta‑carotene) improved red blood cell resistance to oxidative hemolysis and membrane function.
In hospitalized infants with severe ALRI, 5-day adjunctive vitamin C+E did not improve clinical recovery, oxidative stress, or immune skin-test responses.
In hospitalized infants with severe ALRI, 5-day adjunctive vitamin C+E did not improve clinical recovery, oxidative stress, or immune skin-test responses.
In hospitalized infants with severe ALRI, 5-day adjunctive vitamin C+E did not improve clinical recovery, oxidative stress, or immune skin-test responses.
In patients post-colorectal cancer resection, 6 months of calcium plus vitamins A, C, E did not reduce colon epithelial proliferation more than placebo.
In chronic periodontitis patients receiving SRP, 8-week adjunctive CELC (includes vitamin C) produced a small but statistically significant improvement in gingival inflammation (GI) versus control; other periodontal measures were similar.
In chronic periodontitis patients receiving SRP, 8-week adjunctive CELC (includes vitamin C) produced a small but statistically significant improvement in gingival inflammation (GI) versus control; other periodontal measures were similar.
In chronic periodontitis patients receiving SRP, 8-week adjunctive CELC (includes vitamin C) produced a small but statistically significant improvement in gingival inflammation (GI) versus control; other periodontal measures were similar.
Among female regular blood donors, adding 500 mg/day ascorbic acid to ferrous fumarate accelerated hemoglobin and RBC index recovery to pre-donation levels (1 month vs 2–3 months).
In healthy elderly adults, 6 months of 500–1000 mg ascorbic acid plus 400 IU vitamin E did not significantly change oxidative stress markers, antioxidant enzymes, or DNA damage versus placebo.
In healthy elderly adults, 6 months of 500–1000 mg ascorbic acid plus 400 IU vitamin E did not significantly change oxidative stress markers, antioxidant enzymes, or DNA damage versus placebo.
In sepsis patients, IV ascorbic acid combined with thiamine and hydrocortisone shortened time on vasopressors but did not change organ-failure scores or mortality.
In sepsis patients, IV ascorbic acid combined with thiamine and hydrocortisone shortened time on vasopressors but did not change organ-failure scores or mortality.
In schoolchildren, added calcium (100–200 mg/meal) reduced iron absorption by ~18–27%, while ascorbic acid (vitamin C) increased absorption 2–4-fold and overcame the calcium inhibition.
In preschool children, iron absorption from a meal did not differ when served with orange juice versus apple juice.
In schoolchildren, added calcium (100–200 mg/meal) reduced iron absorption by ~18–27%, while ascorbic acid (vitamin C) increased absorption 2–4-fold and overcame the calcium inhibition.
In schoolchildren, added calcium (100–200 mg/meal) reduced iron absorption by ~18–27%, while ascorbic acid (vitamin C) increased absorption 2–4-fold and overcame the calcium inhibition.
For colonoscopy prep, 2 L ascorbic acid–supplemented PEG was less palatable and less often rated excellent than 4 L PEG+menthol but had similar overall cleansing rates.
Low-volume PEG with ascorbic acid cleans as well as standard PEG, tastes better, and split dosing gives the best cleansing.
For colonoscopy prep, 2 L ascorbic acid–supplemented PEG was less palatable and less often rated excellent than 4 L PEG+menthol but had similar overall cleansing rates.
For colonoscopy prep, 2 L ascorbic acid–supplemented PEG was less palatable and less often rated excellent than 4 L PEG+menthol but had similar overall cleansing rates.
Applying a topical serum containing vitamin C (with vitamin E and ferulic acid) after microneedle RF produced greater wrinkle reduction, higher global improvement ratings, and increased elastin on histology versus placebo.
Applying a topical serum containing vitamin C (with vitamin E and ferulic acid) after microneedle RF produced greater wrinkle reduction, higher global improvement ratings, and increased elastin on histology versus placebo.
Large double‑blind randomized trial of vitamin C (500 mg daily) ± other antioxidants assessing long‑term cancer incidence and mortality in women.
Daily 500 mg vitamin C did not change prostate or total cancer risk in this large trial of older male physicians.
Long-term daily vitamin C (500 mg) supplementation did not reduce prostate cancer or total cancer incidence in middle-aged and older men over ~8 years.
Long-term daily vitamin C (500 mg) supplementation did not reduce prostate cancer or total cancer incidence in middle-aged and older men over ~8 years.
Daily 500 mg vitamin C did not change prostate or total cancer risk in this large trial of older male physicians.
In this cohort of 1,985 men, higher intake of vitamin C‑rich vegetables (e.g., bell peppers, broccoli) was associated with lower prostate cancer risk.
Preoperative combined vitamin E and 1 g vitamin C given before bypass did not reduce markers or signs of myocardial injury.
Preoperative combined vitamin E and 1 g vitamin C given before bypass did not reduce markers or signs of myocardial injury.
Preoperative combined vitamin E and 1 g vitamin C given before bypass did not reduce markers or signs of myocardial injury.
Three months of 500 mg/day vitamin C (and selenium arm) showed decreases in TPO antibodies within treated groups, but no significant differences compared with placebo.
Three months of 500 mg/day vitamin C (and selenium arm) showed decreases in TPO antibodies within treated groups, but no significant differences compared with placebo.
Three months of 500 mg/day vitamin C (and selenium arm) showed decreases in TPO antibodies within treated groups, but no significant differences compared with placebo.
One gram/day vitamin C for 8 months did not lower plasma lipoprotein(a) compared with placebo.
A 2-L PEG+ascorbate solution produced similar high-quality colon cleansing but better tolerability and fewer adverse events than standard 4-L PEG.
A 2-L PEG+ascorbate solution produced similar high-quality colon cleansing but better tolerability and fewer adverse events than standard 4-L PEG.
In 62 inpatients, low-volume PEG with ascorbic acid had comparable bowel-cleansing efficacy and tolerability to 2 L PEG plus bisacodyl when given split-dose.
A 2-L PEG+ascorbate solution produced similar high-quality colon cleansing but better tolerability and fewer adverse events than standard 4-L PEG.
Long-term daily supplementation with a capsule containing vitamins and minerals (including 20 mg zinc) did not improve health-related quality of life versus placebo.
In postmenopausal women with coronary disease, antioxidant vitamins (including vitamin C) did not slow artery narrowing and were associated with a suggestion of harm including more deaths.
Large randomized placebo-controlled trial in high-risk adults: combined antioxidant regimen (including vitamin C 250 mg/day) produced no significant reduction in mortality, major vascular events, or cancer over ~5 years.
Large randomized placebo-controlled trial in a high-risk Chinese population; long-term (7.3 years) vitamin supplementation (included 250 mg vitamin C with vitamin E and selenium) reduced gastric cancer incidence and gastric cancer mortality over 22.3 years.
Higher blood vitamin C levels were associated with lower mortality risk in older adults.
In this cohort of middle-aged men, higher combined intake of vitamin C and beta-carotene was associated with lower cancer, coronary, and all-cause mortality over long-term follow-up.
Large randomized placebo-controlled trial in high-risk adults: combined antioxidant regimen (including vitamin C 250 mg/day) produced no significant reduction in mortality, major vascular events, or cancer over ~5 years.
Large randomized placebo-controlled trial in high-risk adults: combined antioxidant regimen (including vitamin C 250 mg/day) produced no significant reduction in mortality, major vascular events, or cancer over ~5 years.
A randomized dietary trial showed the Mediterranean-type diet group had fewer deaths and cancers over 4 years; plasma vitamin C levels increased in the diet group, but the effect cannot be attributed solely to vitamin C.
Randomized placebo-controlled study in hemodialysis patients: IV vitamin C (300 mg postdialysis thrice weekly) reduced lymphocyte DNA oxidation and intracellular ROS and increased hOGG1 expression.
Randomized placebo-controlled study in hemodialysis patients: IV vitamin C (300 mg postdialysis thrice weekly) reduced lymphocyte DNA oxidation and intracellular ROS and increased hOGG1 expression.
Randomized placebo-controlled study in hemodialysis patients: IV vitamin C (300 mg postdialysis thrice weekly) reduced lymphocyte DNA oxidation and intracellular ROS and increased hOGG1 expression.
Double-blind RCT in 110 men with grade 1 hypertension: combined vitamins C (1 g/day) and E lowered 24 h ambulatory systolic, diastolic, and mean arterial blood pressure and increased antioxidant capacity.
Double-blind RCT in 110 men with grade 1 hypertension: combined vitamins C (1 g/day) and E lowered 24 h ambulatory systolic, diastolic, and mean arterial blood pressure and increased antioxidant capacity.
Double-blind RCT in 110 men with grade 1 hypertension: combined vitamins C (1 g/day) and E lowered 24 h ambulatory systolic, diastolic, and mean arterial blood pressure and increased antioxidant capacity.
Placebo-controlled randomized study in young women: vitamins C (1 g/day) + E during 10 weeks strength training increased muscle thickness and strength measures but appeared to attenuate strength/work improvements compared with placebo.
Placebo-controlled randomized study in young women: vitamins C (1 g/day) + E during 10 weeks strength training increased muscle thickness and strength measures but appeared to attenuate strength/work improvements compared with placebo.
Placebo-controlled randomized study in young women: vitamins C (1 g/day) + E during 10 weeks strength training increased muscle thickness and strength measures but appeared to attenuate strength/work improvements compared with placebo.
A low-volume PEG solution containing ascorbic acid provided effective bowel cleansing and better proximal colon cleansing versus comparator in this pilot study.
Multivitamin/mineral supplements given to women undergoing IVF were associated with decreased oxidative stress markers and higher antioxidant vitamin levels in serum and follicular fluid.
Randomized trial comparing AJG522 (contains ascorbic acid) with PEG+E for bowel prep: AJG522 produced faster/better early cleansing, lower preparation volume and higher acceptability.
Randomized trial comparing AJG522 (contains ascorbic acid) with PEG+E for bowel prep: AJG522 produced faster/better early cleansing, lower preparation volume and higher acceptability.
Randomized trial comparing AJG522 (contains ascorbic acid) with PEG+E for bowel prep: AJG522 produced faster/better early cleansing, lower preparation volume and higher acceptability.
Randomized allocation to 500 mg or 1000 mg vitamin C daily for 6 weeks in type 2 diabetic patients; 1000 mg/day produced metabolic improvements whereas 500 mg did not.
In type 2 diabetic patients on metformin, adding 500 mg vitamin C daily for 12 months improved fasting glucose, HbA1c and albumin-to-creatinine ratio versus metformin alone.
Randomized allocation to 500 mg or 1000 mg vitamin C daily for 6 weeks in type 2 diabetic patients; 1000 mg/day produced metabolic improvements whereas 500 mg did not.
Randomized allocation to 500 mg or 1000 mg vitamin C daily for 6 weeks in type 2 diabetic patients; 1000 mg/day produced metabolic improvements whereas 500 mg did not.
Double-blind RCT of blackcurrant juice rich in vitamin C and polyphenols for 6 weeks: raised plasma vitamin C, lowered oxidative stress and improved endothelial function.
Randomized trial adding vitamins C (500 mg b.i.d.) and E to standard H. pylori therapy increased eradication rates compared with standard therapy alone.
Randomized trial adding vitamins C (500 mg b.i.d.) and E to standard H. pylori therapy increased eradication rates compared with standard therapy alone.
Randomized double-blind trial in infertile men given high-dose vitamin C (1000 mg) + vitamin E for 56 days showed no improvement in conventional semen parameters or 24-h sperm survival.
Randomized double-blind trial in infertile men given high-dose vitamin C (1000 mg) + vitamin E for 56 days showed no improvement in conventional semen parameters or 24-h sperm survival.
An antioxidant-rich (vitamin C–containing) diet after acute MI increased plasma vitamin C and reduced lipid peroxidation and cardiac enzyme rise versus control diet.
An antioxidant-rich (vitamin C–containing) diet after acute MI increased plasma vitamin C and reduced lipid peroxidation and cardiac enzyme rise versus control diet.
Intravenous vitamin C reduced oxidative stress and, in enalapril-treated moderate CHF patients, augmented the natriuretic effect of furosemide.
A single 2 g dose of vitamin C before exercise increased heart-rate and norepinephrine responses and improved peak VO2 in post-MI patients.
A single 2 g dose of vitamin C before exercise increased heart-rate and norepinephrine responses and improved peak VO2 in post-MI patients.
A low-cost cafeteria nudge intervention made children take and eat more fruit at lunchtime.
Randomized trial comparing GUMLi formula vs cows' milk in toddlers; reports nutrient intake differences including higher vitamin D intake in the GUMLi group.
A low-cost cafeteria nudge intervention made children take and eat more fruit at lunchtime.
Cross-sectional analysis relating dietary vitamins (including vitamin C) to early AMD signs; higher vitamin A (not vitamin C) intake associated with larger drusen in certain genotypes.
An 18‑week worksite plant‑based dietary intervention increased reported vitamin C intake and other micronutrients among completers.
In this cohort, nonanemic children had higher vitamin C intake than anemic children, suggesting an association between vitamin C intake and lower anemia prevalence.
A 6‑month lifestyle intervention led to weight loss and increased physical activity; measured vitamin C intake (marker of fruit/vegetable intake) showed no difference between groups.
Close dietetic supervision of a Mediterranean-style diet increased antioxidant intake, including vitamin C, and raised plasma antioxidant capacity over 2 months.
Eating two kiwifruit daily increased vitamin C intake and lowered systolic blood pressure by ~2.7 mmHg over 7 weeks, without changing fasting insulin or other metabolic markers.
Individualized nutritional counseling after HSCT improved intake adequacy of several micronutrients, including vitamin C, by day 100.
Adults with metabolic syndrome counseled on DASH diet plus low-sodium vegetable juice (a source of vitamin C) increased vitamin C intake and experienced modestly greater weight loss; oxidative stress markers did not change.
A feeding trial comparing diets raised vitamin C intake and produced substantially greater systolic blood pressure reduction, but the study assessed a whole-diet intervention (not isolated vitamin C).
Randomized trial of DNA-based dietary advice found no significant changes in vitamin C intake at 3 or 12 months compared to controls.
In this cross-sectional study, people with diet-related beliefs about colorectal cancer prevention reported higher vitamin C intake.
A school nutrition intervention increased fruit and vegetable intake by 47% in 7-9-year-olds and produced a borderline increase in vitamin C intake.
In 589 individuals from 169 families, a multifaceted family-based intervention (personalized goal setting + cooking + education) increased dietary vitamin C intake at 3 and 18 months versus education alone.
In women, interpersonal stressors were associated with higher ghrelin, lower leptin, and small/marginal increases in several dietary components including vitamin C intake.
A low-cost cafeteria nudge intervention made children take and eat more fruit at lunchtime.
Monthly volunteer home visits did not change infant vitamin C intake but improved some feeding practices and increased certain fruit/vegetable consumption.
Monthly volunteer home visits did not change infant vitamin C intake but improved some feeding practices and increased certain fruit/vegetable consumption.
In smokers, short-term vitamin C supplements reduced the faster loss of vitamin E seen with smoking.
In smokers, short-term vitamin C supplements reduced the faster loss of vitamin E seen with smoking.
Irvingia gabonensis kernel extract (300 mg/day) in overweight/obese women for 12 weeks raised plasma vitamin C and maintained adiponectin but did not change fat oxidation, body composition, telomere length, or aerobic capacity.
Irvingia gabonensis kernel extract (300 mg/day) in overweight/obese women for 12 weeks raised plasma vitamin C and maintained adiponectin but did not change fat oxidation, body composition, telomere length, or aerobic capacity.
Twenty-eight days of L-arginine (1.66 g twice daily) plus liposomal vitamin C (500 mg twice daily) improved 6-minute walk distance, handgrip strength, endothelial function and markedly reduced fatigue in adults with long COVID.
Twenty-eight days of L-arginine (1.66 g twice daily) plus liposomal vitamin C (500 mg twice daily) improved 6-minute walk distance, handgrip strength, endothelial function and markedly reduced fatigue in adults with long COVID.
Daily fortified yogurt containing HMB, 1000 IU vitamin D, and vitamin C improved handgrip strength, gait speed, vitamin D and IGF-1 levels, and reduced inflammation markers versus control in sarcopenic older adults.
Twenty-eight days of L-arginine (1.66 g twice daily) plus liposomal vitamin C (500 mg twice daily) improved 6-minute walk distance, handgrip strength, endothelial function and markedly reduced fatigue in adults with long COVID.
In 120 patients randomized to several antioxidant regimens (one arm received α-lipoic acid plus vitamin C), none of the treatments, including the vitamin C-containing arm, improved hearing outcomes after six months.
In 120 patients randomized to several antioxidant regimens (one arm received α-lipoic acid plus vitamin C), none of the treatments, including the vitamin C-containing arm, improved hearing outcomes after six months.
In 120 patients randomized to several antioxidant regimens (one arm received α-lipoic acid plus vitamin C), none of the treatments, including the vitamin C-containing arm, improved hearing outcomes after six months.
Tested calcium ascorbate (vitamin C) in osteoarthritis; small reduction in pain versus placebo.
Tested calcium ascorbate (vitamin C) in osteoarthritis; small reduction in pain versus placebo.
Tested calcium ascorbate (vitamin C) in osteoarthritis; small reduction in pain versus placebo.
In elderly postmenopausal women, 12 weeks of treatment including vitamin C showed no clear effect of vitamin C on bone or metabolic markers.
In elderly postmenopausal women, 12 weeks of treatment including vitamin C showed no clear effect of vitamin C on bone or metabolic markers.
In elderly postmenopausal women, 12 weeks of treatment including vitamin C showed no clear effect of vitamin C on bone or metabolic markers.
In young healthy men, 12 weeks of vitamin C+E+folate reduced systolic blood pressure but showed no other clear cardiovascular changes.
In patients with cirrhosis, IV ascorbic acid reduced oxidative marker MDA and markedly blunted the postprandial rise in portal pressure.
In patients with cirrhosis, IV ascorbic acid reduced oxidative marker MDA and markedly blunted the postprandial rise in portal pressure.
Offspring of pregnant smokers given 500 mg/day vitamin C had better lung function at age 5 and less wheeze than offspring of placebo mothers.
Offspring of pregnant smokers given 500 mg/day vitamin C had better lung function at age 5 and less wheeze than offspring of placebo mothers.
Offspring of pregnant smokers given 500 mg/day vitamin C had better lung function at age 5 and less wheeze than offspring of placebo mothers.
In adults with CMT1A, 1.5 g/day ascorbic acid for 24 months did not improve the primary neuropathy score or prespecified secondary outcomes versus placebo.
In adults with CMT1A, 1.5 g/day ascorbic acid for 24 months did not improve the primary neuropathy score or prespecified secondary outcomes versus placebo.
In adults with CMT1A, 1.5 g/day ascorbic acid for 24 months did not improve the primary neuropathy score or prespecified secondary outcomes versus placebo.
In SLE patients, 12 weeks of combined vitamins C and E increased plasma vitamin levels and reduced MDA but did not change endothelial function measures.
In SLE patients, 12 weeks of combined vitamins C and E increased plasma vitamin levels and reduced MDA but did not change endothelial function measures.
Oral nutritional supplements plus dietary counseling increased energy and micronutrient intakes (including calcium), and improved appetite versus counseling alone in picky-eating children over 90 days.
In obese men, alternate-day 1,000 mg vitamin C improved sperm concentration and motility but did not change semen volume or normal morphology.
In obese men, alternate-day 1,000 mg vitamin C improved sperm concentration and motility but did not change semen volume or normal morphology.
In smokers, 2 months of vitamin C supplementation increased plasma antioxidant levels but did not change urinary 8-oxodG (oxidative DNA damage marker).
In smokers, 2 months of vitamin C supplementation increased plasma antioxidant levels but did not change urinary 8-oxodG (oxidative DNA damage marker).
Daily consumption of a dairy product enriched with calcium, vitamin D and other bone‑supporting nutrients for 24 weeks improved bone mass and bone turnover markers and mitigated BMD loss in menopausal women at risk of osteoporosis.
In subjects with resistant hypertension and dyslipidemia, 500 mg/day vitamin C for 8 weeks produced no significant improvements in blood pressure, LDL, or endothelial function.
In subjects with resistant hypertension and dyslipidemia, 500 mg/day vitamin C for 8 weeks produced no significant improvements in blood pressure, LDL, or endothelial function.
In women using oral contraceptives, combined low-dose vitamin C and E supplementation decreased lipid peroxidation (MDA) and increased GPx and GR activities.
Randomized double-blind trial of daily multivitamin and trace element supplement (including zinc 20 mg) vs placebo in adults measuring serum nutrient levels and antioxidant markers over 6 months.
Six-month double-blind RCT in institutionalized elderly: vitamin supplementation (including vitamin C) increased serum vitamin levels and improved enzymatic antioxidant activity.
In women using oral contraceptives, combined low-dose vitamin C and E supplementation decreased lipid peroxidation (MDA) and increased GPx and GR activities.
In cyclists, regimens containing vitamin C (with flavonoids ± n-3) attenuated the immediate postexercise rise in F2-isoprostanes (oxidative stress marker) compared with placebo.
Fourteen days of 500 mg twice-daily vitamin C did not change circulating sICAM-1, neopterin, or neutrophil elastase activity in smokers or non-smokers.
Fourteen days of 500 mg twice-daily vitamin C did not change circulating sICAM-1, neopterin, or neutrophil elastase activity in smokers or non-smokers.
Fourteen days of 500 mg twice-daily vitamin C did not change circulating sICAM-1, neopterin, or neutrophil elastase activity in smokers or non-smokers.
Oral vitamin C given before and after CABG reduced postoperative atrial fibrillation and shortened ICU and hospital stays.
Oral vitamin C given before and after CABG reduced postoperative atrial fibrillation and shortened ICU and hospital stays.
Oral vitamin C given before and after CABG reduced postoperative atrial fibrillation and shortened ICU and hospital stays.
Supplemental ascorbic acid (500 mg twice daily) did not speed healing of pressure ulcers compared with low-dose control in an 88-patient randomized trial.
Supplemental ascorbic acid (500 mg twice daily) did not speed healing of pressure ulcers compared with low-dose control in an 88-patient randomized trial.
Low-volume PEG formulations with increased ascorbate produced high 24-h stool output and effective colon cleansing at lower fluid volumes with tolerable adverse events.
Low-volume PEG formulations with increased ascorbate produced high 24-h stool output and effective colon cleansing at lower fluid volumes with tolerable adverse events.
Low-volume PEG formulations with increased ascorbate produced high 24-h stool output and effective colon cleansing at lower fluid volumes with tolerable adverse events.
High-dose vitamins E and C raised blood antioxidant levels but did not change serum cytokines or muscle strength after ACL surgery.
High-dose vitamins E and C raised blood antioxidant levels but did not change serum cytokines or muscle strength after ACL surgery.
High-dose vitamins E and C raised blood antioxidant levels but did not change serum cytokines or muscle strength after ACL surgery.
Postoperative vitamin C reduced early pain, morphine use, inflammatory CRP levels, swelling and improved short-term hip function similar to dexamethasone but without increasing blood glucose.
Postoperative vitamin C reduced early pain, morphine use, inflammatory CRP levels, swelling and improved short-term hip function similar to dexamethasone but without increasing blood glucose.
Postoperative vitamin C reduced early pain, morphine use, inflammatory CRP levels, swelling and improved short-term hip function similar to dexamethasone but without increasing blood glucose.
In smokers with higher BMI, 500 mg/day vitamin C for 2 months lowered a blood marker of lipid oxidation; no effect in low-BMI smokers.
In smokers with higher BMI, 500 mg/day vitamin C for 2 months lowered a blood marker of lipid oxidation; no effect in low-BMI smokers.
Children given a probiotic consortium plus 50 mg/day vitamin C for 6 months had fewer and shorter upper respiratory infections and less preschool absence versus placebo; study used a combined product so effects cannot be ascribed to vitamin C alone.
Children given a probiotic consortium plus 50 mg/day vitamin C for 6 months had fewer and shorter upper respiratory infections and less preschool absence versus placebo; study used a combined product so effects cannot be ascribed to vitamin C alone.
Children given a probiotic consortium plus 50 mg/day vitamin C for 6 months had fewer and shorter upper respiratory infections and less preschool absence versus placebo; study used a combined product so effects cannot be ascribed to vitamin C alone.
Haemodialysis patients receiving 250 mg/day vitamin C for 8 weeks had large reductions in cramp frequency/intensity compared with placebo; greatest reduction seen with vitamins C+E combined.
Haemodialysis patients receiving 250 mg/day vitamin C for 8 weeks had large reductions in cramp frequency/intensity compared with placebo; greatest reduction seen with vitamins C+E combined.
Haemodialysis patients receiving 250 mg/day vitamin C for 8 weeks had large reductions in cramp frequency/intensity compared with placebo; greatest reduction seen with vitamins C+E combined.
Vitamin C alone or with rutin reduced the percent change in fasting blood glucose over 8 weeks; no clear effect on HbA1c, insulin resistance or oxidative stress; some cholesterol and quality-of-life domains improved in specific groups.
Vitamin C alone or with rutin reduced the percent change in fasting blood glucose over 8 weeks; no clear effect on HbA1c, insulin resistance or oxidative stress; some cholesterol and quality-of-life domains improved in specific groups.
Vitamin C alone or with rutin reduced the percent change in fasting blood glucose over 8 weeks; no clear effect on HbA1c, insulin resistance or oxidative stress; some cholesterol and quality-of-life domains improved in specific groups.
In sepsis survivors, early IV vitamin C with thiamine and hydrocortisone did not improve 6-month outcomes and was associated with worse immediate memory and higher PTSD rates.
In sepsis survivors, early IV vitamin C with thiamine and hydrocortisone did not improve 6-month outcomes and was associated with worse immediate memory and higher PTSD rates.
In sepsis survivors, early IV vitamin C with thiamine and hydrocortisone did not improve 6-month outcomes and was associated with worse immediate memory and higher PTSD rates.
Perfusion of renal grafts with ascorbic acid did not produce significant improvements in graft outcomes (incidence of delayed graft function similar to control).
Perfusion of renal grafts with ascorbic acid did not produce significant improvements in graft outcomes (incidence of delayed graft function similar to control).
In this large randomized trial, a long-term antioxidant vitamin cocktail (including 250 mg vitamin C) showed no benefit on major vascular outcomes (preliminary), while simvastatin produced clear benefit.
In this large randomized trial, a long-term antioxidant vitamin cocktail (including 250 mg vitamin C) showed no benefit on major vascular outcomes (preliminary), while simvastatin produced clear benefit.
In 111 septic shock patients, IV vitamin C plus thiamine for 48 h raised blood vitamin levels but did not improve organ dysfunction (ΔSOFA) or mortality compared with placebo.
In 111 septic shock patients, IV vitamin C plus thiamine for 48 h raised blood vitamin levels but did not improve organ dysfunction (ΔSOFA) or mortality compared with placebo.
Cross-sectional multicentre study (~1,400 people) found no population-level association between fasting plasma vitamin C and gastric cancer rates or markers of gastritis/H. pylori.
Cross-sectional multicentre study (~1,400 people) found no population-level association between fasting plasma vitamin C and gastric cancer rates or markers of gastritis/H. pylori.
Cross-sectional multicentre study (~1,400 people) found no population-level association between fasting plasma vitamin C and gastric cancer rates or markers of gastritis/H. pylori.
Large randomized, double‑blind placebo-controlled primary prevention trial (n=12,735) testing daily nutritional-dose antioxidant supplementation including vitamin C (120 mg); after 2 years biochemical markers rose to nutritional but not excessive levels.
In postmenopausal women with coronary disease, antioxidant vitamins (including vitamin C) did not slow artery narrowing and were associated with a suggestion of harm including more deaths.
In postmenopausal women with coronary disease, antioxidant vitamins (including vitamin C) did not slow artery narrowing and were associated with a suggestion of harm including more deaths.
In children with heterozygous familial hypercholesterolemia, combined vitamin C and E therapy altered plasma fatty acid composition but did not change lipid profile or inflammatory markers.
In children with heterozygous familial hypercholesterolemia, combined vitamin C and E therapy altered plasma fatty acid composition but did not change lipid profile or inflammatory markers.
Higher blood vitamin C levels were associated with lower mortality risk in older adults.
Higher blood vitamin C levels were associated with lower mortality risk in older adults.
Daily vitamin C (1 g) plus vitamin E did not reduce gestational hypertension or preeclampsia and was associated with some increased fetal/perinatal risks.
Daily vitamin C (1 g) plus vitamin E did not reduce gestational hypertension or preeclampsia and was associated with some increased fetal/perinatal risks.
Daily vitamin C (1 g) plus vitamin E did not reduce gestational hypertension or preeclampsia and was associated with some increased fetal/perinatal risks.
Targeted vitamin C supplementation reduced oxidative stress and improved performance in individuals with low vitamin C status but not in unselected controls.
Targeted vitamin C supplementation reduced oxidative stress and improved performance in individuals with low vitamin C status but not in unselected controls.
Targeted vitamin C supplementation reduced oxidative stress and improved performance in individuals with low vitamin C status but not in unselected controls.
Intravenous hydration plus oral ascorbic acid did not significantly change contrast-induced nephropathy rates but reduced postprocedural worsening of renal function.
Adding ascorbic acid to saline + N-acetylcysteine did not reduce contrast-induced nephropathy compared with saline + N-acetylcysteine alone; bicarbonate + NAC was superior.
Intravenous hydration plus oral ascorbic acid did not significantly change contrast-induced nephropathy rates but reduced postprocedural worsening of renal function.
Adding 500 mg vitamin C to the Bier block reduced the incidence of CRPS after distal radius fracture surgery compared with control.
Large observational cohort: heavier soup consumers had higher dietary vitamin C intake; serum vitamin C was slightly higher but not significantly.
Large randomized trial in pregnant women with type 1 diabetes: vitamins C+E increased blood vitamin levels but did not reduce pre-eclampsia or gestational hypertension overall.
Randomized trial: vitamins C+E did not alter improvements in VO2max or performance but blocked increases in mitochondrial biogenesis markers in trained muscle.
Randomized trial: vitamins C+E did not alter improvements in VO2max or performance but blocked increases in mitochondrial biogenesis markers in trained muscle.
Randomized trial: vitamins C+E did not alter improvements in VO2max or performance but blocked increases in mitochondrial biogenesis markers in trained muscle.
Daily 500 mg vitamin C modestly reduced new gout diagnoses in middle-aged male physicians.
Community dietary education increased reported vitamin C intake modestly but produced only minimal change in serum ascorbic acid.
Cross‑sectional baseline data from 159 urban African Americans with uncontrolled hypertension showed overall vitamin C intake higher than recommendations, but below‑median intake was associated with greater albuminuria.
Spraying vitamin C solution after Lugol iodine staining reduced acute adverse reactions and sped decolorization of the esophageal mucosa compared with distilled water and performed similarly to sodium thiosulfate.
Spraying vitamin C solution after Lugol iodine staining reduced acute adverse reactions and sped decolorization of the esophageal mucosa compared with distilled water and performed similarly to sodium thiosulfate.
Spraying vitamin C solution after Lugol iodine staining reduced acute adverse reactions and sped decolorization of the esophageal mucosa compared with distilled water and performed similarly to sodium thiosulfate.
Vitamin C (1000 mg/day) reduced lipid peroxidation markers and increased some antioxidant enzymes and certain hematological parameters in power plant workers.
Vitamin C (1000 mg/day) reduced lipid peroxidation markers and increased some antioxidant enzymes and certain hematological parameters in power plant workers.
In young healthy adults simulated train noise worsened sleep and endothelial function; oral vitamin C (2 g) given acutely improved endothelial function after noise nights in women but not men.
In young healthy adults simulated train noise worsened sleep and endothelial function; oral vitamin C (2 g) given acutely improved endothelial function after noise nights in women but not men.
In young healthy adults simulated train noise worsened sleep and endothelial function; oral vitamin C (2 g) given acutely improved endothelial function after noise nights in women but not men.
In a multicenter randomized trial 1‑L PEG with ascorbic acid was non‑inferior to 2‑L PEG+AA for bowel cleaning before small bowel capsule endoscopy.
In a multicenter randomized trial 1‑L PEG with ascorbic acid was non‑inferior to 2‑L PEG+AA for bowel cleaning before small bowel capsule endoscopy.
In a multicenter randomized trial 1‑L PEG with ascorbic acid was non‑inferior to 2‑L PEG+AA for bowel cleaning before small bowel capsule endoscopy.
In Fabry patients and controls IV ascorbate reduced cerebral blood flow; patients had lower baseline plasma ascorbate and higher myeloperoxidase levels.
In Fabry patients and controls IV ascorbate reduced cerebral blood flow; patients had lower baseline plasma ascorbate and higher myeloperoxidase levels.
In Fabry patients and controls IV ascorbate reduced cerebral blood flow; patients had lower baseline plasma ascorbate and higher myeloperoxidase levels.
Post-hoc biomarker analysis of a multicenter randomized placebo-controlled trial (CITRIS-ALI) in sepsis-induced ARDS: high-dose IV vitamin C attenuated rises in plasma cfDNA and syndecan-1 at 48 h and these biomarker changes correlated with oxygenation and 28-day mortality.
Post-hoc biomarker analysis of a multicenter randomized placebo-controlled trial (CITRIS-ALI) in sepsis-induced ARDS: high-dose IV vitamin C attenuated rises in plasma cfDNA and syndecan-1 at 48 h and these biomarker changes correlated with oxygenation and 28-day mortality.
Post-hoc biomarker analysis of a multicenter randomized placebo-controlled trial (CITRIS-ALI) in sepsis-induced ARDS: high-dose IV vitamin C attenuated rises in plasma cfDNA and syndecan-1 at 48 h and these biomarker changes correlated with oxygenation and 28-day mortality.
Randomized study of 104 H. pylori–infected patients: adding vitamin C (250 mg) and E to standard triple therapy did not improve eradication and was associated with lower eradication rates in metronidazole-susceptible infections.
Randomized study of 104 H. pylori–infected patients: adding vitamin C (250 mg) and E to standard triple therapy did not improve eradication and was associated with lower eradication rates in metronidazole-susceptible infections.
Randomized study of 104 H. pylori–infected patients: adding vitamin C (250 mg) and E to standard triple therapy did not improve eradication and was associated with lower eradication rates in metronidazole-susceptible infections.
Randomized single-blind trial in patients with melasma found both treatments reduced severity; hydroquinone+ascorbic acid gave greater melanin index reduction.
Double-blind RCT in post-menopausal women (159 completers) testing an oral multi-ingredient supplement (not collagen); reported reduced wrinkle depth and increased skin collagen deposition in biopsies.
Double-blind RCT in post-menopausal women (159 completers) testing an oral multi-ingredient supplement (not collagen); reported reduced wrinkle depth and increased skin collagen deposition in biopsies.
In male smokers with mixed high lipids, antioxidant supplementation (including vitamin C) raised serum vitamin E and made LDL less prone to oxidative modification in vitro.
In male smokers with mixed high lipids, antioxidant supplementation (including vitamin C) raised serum vitamin E and made LDL less prone to oxidative modification in vitro.
In male smokers with mixed high lipids, antioxidant supplementation (including vitamin C) raised serum vitamin E and made LDL less prone to oxidative modification in vitro.
Six weeks of high-dose vitamin C plus vitamin E raised blood antioxidant levels but did not reduce exercise-induced muscle damage or loss of strength after a 50-km run.
Six weeks of high-dose vitamin C plus vitamin E raised blood antioxidant levels but did not reduce exercise-induced muscle damage or loss of strength after a 50-km run.
Six weeks of high-dose vitamin C plus vitamin E raised blood antioxidant levels but did not reduce exercise-induced muscle damage or loss of strength after a 50-km run.
In outpatients undergoing colonoscopy, the low-volume PEG with ascorbic acid prep had similar bowel cleansing efficacy and detection rates to comparator but higher compliance.
In outpatients undergoing colonoscopy, the low-volume PEG with ascorbic acid prep had similar bowel cleansing efficacy and detection rates to comparator but higher compliance.
In outpatients undergoing colonoscopy, the low-volume PEG with ascorbic acid prep had similar bowel cleansing efficacy and detection rates to comparator but higher compliance.
A 2-L PEG solution plus ascorbic acid cleaned the colon as well as 4-L PEG, with better taste and higher patient compliance.
1-L PEG plus ascorbate was noninferior to 4-L PEG for colon cleansing, had higher patient compliance, and similar safety.
In patients with acute MI, combined vitamin C+E supplementation reduced neutrophil oxidative radical production and limited lipid peroxidation versus usual care.
In patients with acute MI, combined vitamin C+E supplementation reduced neutrophil oxidative radical production and limited lipid peroxidation versus usual care.
In patients with acute MI, combined vitamin C+E supplementation reduced neutrophil oxidative radical production and limited lipid peroxidation versus usual care.
Oral ascorbic acid (2 g) increased the duration of forearm reactive hyperaemia in hypercholesterolaemic patients but did not change peak blood flow.
Oral ascorbic acid (2 g) increased the duration of forearm reactive hyperaemia in hypercholesterolaemic patients but did not change peak blood flow.
Large double‑blind randomized trial of vitamin C (500 mg daily) ± other antioxidants assessing long‑term cancer incidence and mortality in women.
In this cohort of middle-aged men, higher combined intake of vitamin C and beta-carotene was associated with lower cancer, coronary, and all-cause mortality over long-term follow-up.
In this cohort of middle-aged men, higher combined intake of vitamin C and beta-carotene was associated with lower cancer, coronary, and all-cause mortality over long-term follow-up.
In pregnant women with moderate IDA, ferrous ascorbate produced the largest mean hemoglobin rise and had fewer gastrointestinal adverse effects than ferrous sulphate over 90 days.
In pregnant women with moderate IDA, ferrous ascorbate produced the largest mean hemoglobin rise and had fewer gastrointestinal adverse effects than ferrous sulphate over 90 days.
In pregnant women with moderate IDA, ferrous ascorbate produced the largest mean hemoglobin rise and had fewer gastrointestinal adverse effects than ferrous sulphate over 90 days.
Six weeks of 1000 mg/day vitamin C in poorly controlled T2D lowered blood pressure and reduced oxidative stress markers while increasing plasma ascorbate and NO compared with placebo.
Six weeks of 1000 mg/day vitamin C in poorly controlled T2D lowered blood pressure and reduced oxidative stress markers while increasing plasma ascorbate and NO compared with placebo.
Six weeks of 1000 mg/day vitamin C in poorly controlled T2D lowered blood pressure and reduced oxidative stress markers while increasing plasma ascorbate and NO compared with placebo.
Two 1-L bowel‑prep solutions containing ascorbic acid cleaned the colon equally well; one (CleanViewAL) tasted slightly better and no serious side effects occurred.
PEG with ascorbate components (2 L) produced substantially higher successful bowel cleansing than sodium phosphate and was well tolerated.
Two 1-L bowel‑prep solutions containing ascorbic acid cleaned the colon equally well; one (CleanViewAL) tasted slightly better and no serious side effects occurred.
Two 1-L bowel‑prep solutions containing ascorbic acid cleaned the colon equally well; one (CleanViewAL) tasted slightly better and no serious side effects occurred.
A 3-week fruit/vegetable concentrate raised blood vitamin C and some antioxidants but did not change markers of oxidative damage in male smokers.
In elderly outpatients, 2‑L PEG‑ascorbic acid was non‑inferior to oral sulfate solution for colon cleansing and had lower rates of vomiting and thirst.
1 L PEG with ascorbic acid achieved similarly high adequate bowel-prep rates to oral sodium sulfate but caused more thirst and dizziness.
In elderly outpatients, 2‑L PEG‑ascorbic acid was non‑inferior to oral sulfate solution for colon cleansing and had lower rates of vomiting and thirst.
In elderly outpatients, 2‑L PEG‑ascorbic acid was non‑inferior to oral sulfate solution for colon cleansing and had lower rates of vomiting and thirst.
High‑dose vitamin C (3×1000 mg/day for 8 days) did not reduce markers or symptoms of delayed onset muscle soreness after eccentric exercise.
High‑dose vitamin C (3×1000 mg/day for 8 days) did not reduce markers or symptoms of delayed onset muscle soreness after eccentric exercise.
High‑dose vitamin C (3×1000 mg/day for 8 days) did not reduce markers or symptoms of delayed onset muscle soreness after eccentric exercise.
Higher intake of vitamin C–rich fruits and vegetables was associated with slightly higher hemoglobin in the whole sample and higher ferritin in premenopausal women.
Higher intake of vitamin C–rich fruits and vegetables was associated with slightly higher hemoglobin in the whole sample and higher ferritin in premenopausal women.
In power-plant workers, daily vitamin C (1,000 mg) reduced markers of DNA damage measured by comet assay but did not change apoptosis measures.
In power-plant workers, daily vitamin C (1,000 mg) reduced markers of DNA damage measured by comet assay but did not change apoptosis measures.
Vitamin A+C given for 1 month produced mixed effects on oxidative-stress markers: some markers improved in HIV-only patients but worsened or did not improve in HIV-TB co-infected patients.
In HNC patients on cisplatin, the control group given vitamins C+E showed increases in SOD and decreases in MDA, but astaxanthin produced larger MDA reductions.
In healthy volunteers, vitamin E supplementation markedly raised platelet alpha-tocopherol and reduced platelet function; vitamin C and beta-carotene showed no significant effects.
In patients with intermittent claudication, vitamin C administration prevented exercise-induced impairment of endothelial function and rises in oxidative stress markers.
In this randomized investigator-blind trial in Korean patients, oral sulfate solution produced superior overall bowel cleansing compared with 2-L ascorbic acid plus PEG.
In this randomized investigator-blind trial in Korean patients, oral sulfate solution produced superior overall bowel cleansing compared with 2-L ascorbic acid plus PEG.
In this randomized investigator-blind trial in Korean patients, oral sulfate solution produced superior overall bowel cleansing compared with 2-L ascorbic acid plus PEG.
In women with functional hypercortisolemia, 1000 mg/day vitamin C for 2 months significantly lowered elevated cortisol and DHEA-S levels compared with untreated controls.
Intravenous ascorbic acid did not attenuate etomidate-induced suppression of adrenal steroid production in this small clinical study.
In women with functional hypercortisolemia, 1000 mg/day vitamin C for 2 months significantly lowered elevated cortisol and DHEA-S levels compared with untreated controls.
Randomized trial (n=200) comparing low-volume PEG+ascorbic acid vs sodium picosulfate+magnesium citrate for colon cleansing; similar efficacy but better tolerance with PEG+ascorbic.
Randomized trial (n=200) comparing low-volume PEG+ascorbic acid vs sodium picosulfate+magnesium citrate for colon cleansing; similar efficacy but better tolerance with PEG+ascorbic.
Randomized trial (n=200) comparing low-volume PEG+ascorbic acid vs sodium picosulfate+magnesium citrate for colon cleansing; similar efficacy but better tolerance with PEG+ascorbic.
Two related studies in haemodialysis patients (small RCT n=21 and larger 3-month cohort n=153) found no improvement in haemoglobin or iron availability with oral or IV ascorbic acid; plasma AA rose and serum oxalate increased.
Two related studies in haemodialysis patients (small RCT n=21 and larger 3-month cohort n=153) found no improvement in haemoglobin or iron availability with oral or IV ascorbic acid; plasma AA rose and serum oxalate increased.
Two related studies in haemodialysis patients (small RCT n=21 and larger 3-month cohort n=153) found no improvement in haemoglobin or iron availability with oral or IV ascorbic acid; plasma AA rose and serum oxalate increased.
6-week randomized prospective study in 80 postmenopausal women (40 with T2D) showing HRT ± vitamin C/E associated with improved kidney and liver biochemical markers in diabetic women but no change in thyroid hormones.
6-week randomized prospective study in 80 postmenopausal women (40 with T2D) showing HRT ± vitamin C/E associated with improved kidney and liver biochemical markers in diabetic women but no change in thyroid hormones.
6-week randomized prospective study in 80 postmenopausal women (40 with T2D) showing HRT ± vitamin C/E associated with improved kidney and liver biochemical markers in diabetic women but no change in thyroid hormones.
Randomized, placebo‑controlled crossover study in 30 male smokers found minor acute cardiovascular effects; moderate vitamins increased vagal HR control but antioxidants did not change baroreflex sensitivity.
Randomized, placebo‑controlled crossover study in 30 male smokers found minor acute cardiovascular effects; moderate vitamins increased vagal HR control but antioxidants did not change baroreflex sensitivity.
Randomized, placebo‑controlled crossover study in 30 male smokers found minor acute cardiovascular effects; moderate vitamins increased vagal HR control but antioxidants did not change baroreflex sensitivity.
Rehab plus oral collagen-containing supplement produced greater and more sustained improvements in pain, disability, and physical QoL than rehab alone.
Rehab plus oral collagen-containing supplement produced greater and more sustained improvements in pain, disability, and physical QoL than rehab alone.
Rehab plus oral collagen-containing supplement produced greater and more sustained improvements in pain, disability, and physical QoL than rehab alone.
Long-term low-dose antioxidant/multi-mineral supplementation (including 20 mg zinc) reduced total cancer incidence and all-cause mortality in men but not in women over ~7.5 years.
Large randomized trial of daily low-dose antioxidant supplement (included 20 mg Zn) showed lower total cancer incidence in men but not in women after 7.5 years.
Long-term low-dose antioxidant supplementation (including 120 mg vitamin C) did not affect vascular disease but lowered total cancer incidence in men.
Large randomized trial of daily low-dose antioxidant supplement (included 20 mg Zn) showed lower total cancer incidence in men but not in women after 7.5 years.
Large randomized trial of daily low-dose antioxidant supplement (included 20 mg Zn) showed lower total cancer incidence in men but not in women after 7.5 years.
In a randomized crossover study in male blood donors, elemental iron powders were less well absorbed than ferrous sulfate; electrolytic iron given with 50 mg ascorbic acid showed absorption similar to ferrous sulfate.
Adults advised to eat more fruit and vegetables for eight weeks had higher plasma vitamin C and carotenoids but no change in lipids.
A 6-month school feeding intervention with cowpea-based food plus a vitamin C-rich drink increased hemoglobin and reduced anemia prevalence in children.
Fortified porridge given for 6 months raised hemoglobin and ferritin and improved motor development in infants.
A fortified drink given 6 days/week for 8 weeks reduced vitamin B12 deficiency prevalence and increased vitamin B12 concentration and hemoglobin in schoolchildren.
Weekly or daily micronutrient supplements including zinc raised hemoglobin, serum zinc, and retinol versus placebo; growth improved only in children who were stunted at baseline.
Children given improved gruel with or without a multi-micronutrient mix (including iodine) both showed Hb increases; the micronutrient mix added no significant benefit.
Anemic children given iron/folate improved hemoglobin; adding vitamins A and C helped restore iron stores faster.
Daily mungbean meal with guava (high vitamin C) for 7 months increased hemoglobin and reduced anemia prevalence but did not increase body iron stores.
In 324 anemic adolescent girls, once- or twice-weekly multiple micronutrient supplements (including vitamin C) improved vitamin C status and several other micronutrients compared with iron+folic acid over 52 weeks; hemoglobin differences were minimal overall.
Home fortification micronutrient powder (contains vitamin C among others) was at least as effective as iron–folic acid tablets in maintaining hemoglobin during pregnancy, though adherence was lower.
Daily low-dose MNP containing bioavailable iron and 2.5 mg zinc reduced iron and zinc deficiencies and modestly improved weight-for-age over 23 weeks.
Daily mungbean meal with guava (high vitamin C) for 7 months increased hemoglobin and reduced anemia prevalence but did not increase body iron stores.
In adults with septic shock, combination therapy including ascorbic acid did not significantly reduce organ failure (SOFA score), kidney failure, or 30-day mortality versus placebo.
In adults with septic shock, combination therapy including ascorbic acid did not significantly reduce organ failure (SOFA score), kidney failure, or 30-day mortality versus placebo.
Older adults received vitamin C/E with or without resistance training for 6 months; antioxidant profile improved but strength did not change and body composition changed significantly.
Older adults received vitamin C/E with or without resistance training for 6 months; antioxidant profile improved but strength did not change and body composition changed significantly.
Older adults received vitamin C/E with or without resistance training for 6 months; antioxidant profile improved but strength did not change and body composition changed significantly.
In men with mildly elevated homocysteine, B‑group vitamin supplementation (including cyanocobalamin) reduced plasma homocysteine over 8 weeks.
Vitamin C co-infusion tended to improve endothelial responses in some treatment groups but changes were not statistically significant versus placebo.
Combined vitamin C+E prevented the training-related reduction in exercise-induced plasma IL-6 and increased some oxidative stress markers.
Combined vitamin C+E prevented the training-related reduction in exercise-induced plasma IL-6 and increased some oxidative stress markers.
Vitamin C alone lowered P-selectin and combined vitamin E+C lowered ICAM-1 over 6 months in patients with aortic stenosis.
Vitamin C alone lowered P-selectin and combined vitamin E+C lowered ICAM-1 over 6 months in patients with aortic stenosis.
Oral 1 g vitamin C increased plasma vitamin C and attenuated exercise-induced oxidative stress markers in type 1 diabetic patients and healthy controls.
In 30 HCV patients, adding black cumin and vitamin C to standard antivirals showed small improvements in hematologic and antioxidant markers and a significant drop in fasting glucose, but most comparisons were not statistically significant.
In a randomized double-blind crossover trial, diabetics received magnesium or vitamin C to assess effects on blood pressure, glucose and lipids.
In a randomized double-blind crossover trial, diabetics received magnesium or vitamin C to assess effects on blood pressure, glucose and lipids.
In type 2 diabetic men on metformin, daily vitamin C (alone or with vitamin E) for 90 days improved glycemic control, insulin resistance measures, and some oxidative stress markers versus placebo.
In type 2 diabetic patients on metformin, adding 500 mg vitamin C daily for 12 months improved fasting glucose, HbA1c and albumin-to-creatinine ratio versus metformin alone.
In a randomized trial of T2DM patients, combined vitamin C (500 mg) and chromium (200 µg) for the treatment group (n=30) improved glycemic control (HbA1c), lipid profile, liver enzymes and BMI versus placebo.
In a randomized double-blind crossover trial, diabetics received magnesium or vitamin C to assess effects on blood pressure, glucose and lipids.
A 12-week trial of combined antioxidants including vitamin C (100 mg/day) reduced oxidative damage markers and prevented micronucleus increases versus placebo, with effects influenced by folate status.
A 12-week trial of combined antioxidants including vitamin C (100 mg/day) reduced oxidative damage markers and prevented micronucleus increases versus placebo, with effects influenced by folate status.
In 62 inpatients, low-volume PEG with ascorbic acid had comparable bowel-cleansing efficacy and tolerability to 2 L PEG plus bisacodyl when given split-dose.
In 62 inpatients, low-volume PEG with ascorbic acid had comparable bowel-cleansing efficacy and tolerability to 2 L PEG plus bisacodyl when given split-dose.
Multicenter randomized trial (per-protocol n=211) found OST noninferior to 2 L-PEG with ascorbic acid for bowel cleansing and showed better tolerability measures for OST.
Multicenter randomized trial (per-protocol n=211) found OST noninferior to 2 L-PEG with ascorbic acid for bowel cleansing and showed better tolerability measures for OST.
Multicenter randomized trial (per-protocol n=211) found OST noninferior to 2 L-PEG with ascorbic acid for bowel cleansing and showed better tolerability measures for OST.
Small randomized double-blind placebo-controlled trial of topical ascorbic acid solution showed faster lesion healing and reduced virus culture positivity.
Small randomized double-blind placebo-controlled trial of topical ascorbic acid solution showed faster lesion healing and reduced virus culture positivity.
In 589 individuals from 169 families, a multifaceted family-based intervention (personalized goal setting + cooking + education) increased dietary vitamin C intake at 3 and 18 months versus education alone.
Nutrition education classes reduced fat intake and increased fiber and ascorbic acid (vitamin C) intake among postmenopausal women, especially in those motivated to change.
In 589 individuals from 169 families, a multifaceted family-based intervention (personalized goal setting + cooking + education) increased dietary vitamin C intake at 3 and 18 months versus education alone.
Perioperative vitamin C did not reduce postoperative acute kidney injury or change key renal function measures after elective on-pump CABG.
Perioperative vitamin C did not reduce postoperative acute kidney injury or change key renal function measures after elective on-pump CABG.
Perioperative vitamin C did not reduce postoperative acute kidney injury or change key renal function measures after elective on-pump CABG.
In type 2 diabetic patients, 1000 mg/day vitamin C for six weeks significantly reduced anxiety compared with vitamin E and placebo, with no effect on stress or depression.
In type 2 diabetic patients, 1000 mg/day vitamin C for six weeks significantly reduced anxiety compared with vitamin E and placebo, with no effect on stress or depression.
In type 2 diabetic patients, 1000 mg/day vitamin C for six weeks significantly reduced anxiety compared with vitamin E and placebo, with no effect on stress or depression.
In patients starting hemodialysis, 1000 mg/day vitamin C for one year attenuated the rise in LDL oxidation products (TBARS) compared with placebo, with mixed results for other oxidation markers.
In patients starting hemodialysis, 1000 mg/day vitamin C for one year attenuated the rise in LDL oxidation products (TBARS) compared with placebo, with mixed results for other oxidation markers.
In patients starting hemodialysis, 1000 mg/day vitamin C for one year attenuated the rise in LDL oxidation products (TBARS) compared with placebo, with mixed results for other oxidation markers.
Topical sodium ascorbyl phosphate (a vitamin C derivative) combined with PKEK reduced skin pigmentation more than SAP alone in several small controlled cohorts.
Low-volume PEG with ascorbic acid cleans as well as standard PEG, tastes better, and split dosing gives the best cleansing.
In healthy adults, low-dose ascorbic acid added to 1‑L PEG gave similar bowel cleansing, better tolerability than 2‑L PEG‑Asc, and less residual gastric fluid than standard 1‑L PEG‑Asc.
In healthy adults, low-dose ascorbic acid added to 1‑L PEG gave similar bowel cleansing, better tolerability than 2‑L PEG‑Asc, and less residual gastric fluid than standard 1‑L PEG‑Asc.
Compared colonoscopy preparations; the low-volume PEG with ascorbic acid (PEGA) had similar cleansing efficacy to PEG when regimens matched and was better tolerated than PEG.
Compared bowel preparations including polyethylene glycol with ascorbic acid and found similar optimal preparation intervals and overall efficacy; tolerability depended on product type.
12-week triple-blind randomized placebo-controlled trial in women showed that a drinkable supplement containing collagen peptides and dermonutrients improved dermal collagen structure and subjective skin measures without adverse events.
In healthy adults, low-dose ascorbic acid added to 1‑L PEG gave similar bowel cleansing, better tolerability than 2‑L PEG‑Asc, and less residual gastric fluid than standard 1‑L PEG‑Asc.
In corticosteroid‑dependent asthma patients, adding antioxidants including CoQ10, vitamin E and 250 mg vitamin C/day was associated with reduced corticosteroid requirements.
An ascorbic acid–enriched PEG solution prepared the bowel as well as standard PEG with a lower total drinking volume.
In patients with inactive ulcerative colitis, OSS was non‑inferior to 2‑L PEG+ascorbic acid for bowel preparation, with similar tolerability and no effect on disease activity.
In patients with inactive ulcerative colitis, OSS was non‑inferior to 2‑L PEG+ascorbic acid for bowel preparation, with similar tolerability and no effect on disease activity.
In patients with inactive ulcerative colitis, OSS was non‑inferior to 2‑L PEG+ascorbic acid for bowel preparation, with similar tolerability and no effect on disease activity.
In NASH patients, combined vitamin E and vitamin C for 6 months improved liver fibrosis scores but did not change inflammation or ALT.
In young women consuming whole diets, higher vitamin C content increased non‑heme iron absorption compared with low vitamin C diets.
In young women consuming whole diets, higher vitamin C content increased non‑heme iron absorption compared with low vitamin C diets.
Two-week antioxidant supplementation (vitamin C + E or fruit/veg powder) reduced some exercise-induced oxidative stress markers in men and women.
Two-week antioxidant supplementation (vitamin C + E or fruit/veg powder) reduced some exercise-induced oxidative stress markers in men and women.
Six months of combined high-dose vitamins C and E raised plasma antioxidant levels but did not improve coronary or brachial endothelial function in CAD patients.
Six months of combined high-dose vitamins C and E raised plasma antioxidant levels but did not improve coronary or brachial endothelial function in CAD patients.
Immediate vitamin C (1 g/day) during MI reduced platelet-derived microparticles more than control and markedly reduced endothelial-derived microparticles in higher-risk subgroups.
Immediate vitamin C (1 g/day) during MI reduced platelet-derived microparticles more than control and markedly reduced endothelial-derived microparticles in higher-risk subgroups.
Immediate vitamin C (1 g/day) during MI reduced platelet-derived microparticles more than control and markedly reduced endothelial-derived microparticles in higher-risk subgroups.
A wound-specific oral supplement containing arginine, vitamin C and zinc was less effective for wound-healing than a standard nutrition supplement in patients with chronic wounds.
A wound-specific oral supplement containing arginine, vitamin C and zinc was less effective for wound-healing than a standard nutrition supplement in patients with chronic wounds.
In type 2 diabetic patients, combined mineral (Mg+Zn) plus vitamins C+E increased HDL cholesterol and apolipoprotein A1 over 3 months; Mg+Zn alone showed no significant changes.
In type 2 diabetic patients, combined mineral (Mg+Zn) plus vitamins C+E increased HDL cholesterol and apolipoprotein A1 over 3 months; Mg+Zn alone showed no significant changes.
Secondary analysis of a large RCT (ATBC) shows that dietary vitamin C intake modifies harms from high-dose β-carotene supplementation in specific smoker subgroups; this is an interaction analysis rather than a vitamin C trial.
Secondary analysis of a large RCT (ATBC) shows that dietary vitamin C intake modifies harms from high-dose β-carotene supplementation in specific smoker subgroups; this is an interaction analysis rather than a vitamin C trial.
In adults undergoing colonoscopy, a 2-L PEG solution with ascorbic acid achieved at least as good (and in some metrics better) bowel cleansing and higher acceptability than standard 4-L PEG.
In adults undergoing colonoscopy, a 2-L PEG solution with ascorbic acid achieved at least as good (and in some metrics better) bowel cleansing and higher acceptability than standard 4-L PEG.
In men with untreated prostate cancer, a combined supplement including vitamin C produced no change in PSA or sex-hormone levels over 21 weeks.
In men with untreated prostate cancer, a combined supplement including vitamin C produced no change in PSA or sex-hormone levels over 21 weeks.
Local intra-arterial vitamin C prevented ischemia-reperfusion–induced impairment of endothelium-dependent vasodilation in healthy volunteers and patients with PAD.
Local intra-arterial vitamin C prevented ischemia-reperfusion–induced impairment of endothelium-dependent vasodilation in healthy volunteers and patients with PAD.
Local intra-arterial vitamin C prevented ischemia-reperfusion–induced impairment of endothelium-dependent vasodilation in healthy volunteers and patients with PAD.
In a crossover human experiment, vitamin C infusion during recovery from hypoglycemia with hyperglycemia attenuated the worsening of endothelial function and increases in oxidative stress and inflammation.
In a crossover human experiment, vitamin C infusion during recovery from hypoglycemia with hyperglycemia attenuated the worsening of endothelial function and increases in oxidative stress and inflammation.
In a placebo-controlled RCT in pregnant high-risk women, daily vitamin C (1000 mg) + vitamin E increased rates of PROM and PPROM compared with placebo.
In a placebo-controlled RCT in pregnant high-risk women, daily vitamin C (1000 mg) + vitamin E increased rates of PROM and PPROM compared with placebo.
Randomized cross-over trial in hemodialysis patients with low vitamin C showed that 200 mg/day oral vitamin C raised plasma vitamin C and reduced hs-CRP; some nutritional markers trended upward.
Daily fortified yogurt containing HMB, 1000 IU vitamin D, and vitamin C improved handgrip strength, gait speed, vitamin D and IGF-1 levels, and reduced inflammation markers versus control in sarcopenic older adults.
Randomized cross-over trial in hemodialysis patients with low vitamin C showed that 200 mg/day oral vitamin C raised plasma vitamin C and reduced hs-CRP; some nutritional markers trended upward.
Single-blind randomized trial in male COPD patients found that vitamin C (alone) improved antioxidant status (notably plasma glutathione) and helped nutritional measures over six months.
Single-blind randomized trial in male COPD patients found that vitamin C (alone) improved antioxidant status (notably plasma glutathione) and helped nutritional measures over six months.
In this small RCT of severe acute pancreatitis, daily antioxidant vitamins including 1 g vitamin C did not significantly change organ dysfunction or oxidative stress markers versus standard care.
In this small RCT of severe acute pancreatitis, daily antioxidant vitamins including 1 g vitamin C did not significantly change organ dysfunction or oxidative stress markers versus standard care.
In older adults undertaking regular exercise, a multi-ingredient antioxidant beverage (containing vitamin C among others) prevented exercise-induced increases in markers of lipid, protein and DNA oxidation and normalized glutathione and vitamin C levels.
Laser-assisted delivery followed by topical growth factors+vitamin C or vitamin C alone reduced scar roughness and volume; adding growth factors produced significantly better scar improvement.
Laser-assisted delivery followed by topical growth factors+vitamin C or vitamin C alone reduced scar roughness and volume; adding growth factors produced significantly better scar improvement.
High‑dose IV vitamin C for 48 h after cardiac surgery greatly reduced serious postoperative lung complications, improved oxygenation, and lowered mortality.
High‑dose IV vitamin C for 48 h after cardiac surgery greatly reduced serious postoperative lung complications, improved oxygenation, and lowered mortality.
High‑dose IV vitamin C for 48 h after cardiac surgery greatly reduced serious postoperative lung complications, improved oxygenation, and lowered mortality.
Dietary vitamin C intake was not associated with colorectal cancer risk in this case–control study.
Large prospective cohort of male smokers found no link between dietary or serum antioxidant vitamins (including vitamin C) and colorectal cancer risk.
Adding IV N‑acetylcysteine plus vitamin C did not lower overall contrast‑induced nephropathy incidence but reduced oxidative stress markers and lessened cystatin‑C rises in affected patients.
Adding IV N‑acetylcysteine plus vitamin C did not lower overall contrast‑induced nephropathy incidence but reduced oxidative stress markers and lessened cystatin‑C rises in affected patients.
Adding IV N‑acetylcysteine plus vitamin C did not lower overall contrast‑induced nephropathy incidence but reduced oxidative stress markers and lessened cystatin‑C rises in affected patients.
Preoperative multi-vitamin/mineral supplementation (which tended to raise 25(OH)D) significantly blunted the postoperative rise in the IL-6/IL-10 ratio after total knee arthroplasty.
Preoperative multi-vitamin/mineral supplementation (which tended to raise 25(OH)D) significantly blunted the postoperative rise in the IL-6/IL-10 ratio after total knee arthroplasty.
Preoperative multi-vitamin/mineral supplementation (which tended to raise 25(OH)D) significantly blunted the postoperative rise in the IL-6/IL-10 ratio after total knee arthroplasty.
Oral ascorbic acid 500 mg/day was associated with a lower incidence of restenosis after PTCA compared with controls in this preliminary study.
Topical formulations including 5% ascorbyl glucosamine (vitamin C derivative) showed no clear benefit on solar lentigines in this pilot study.
PEG with ascorbic acid bowel prep had similar electrolyte changes to 4-L PEG but better taste and higher willingness to repeat.
1 L polyethylene glycol with ascorbic acid plus a low-residue diet provided similar or better bowel cleansing and greater patient satisfaction than 2 L PEGA.
PEG with ascorbic acid bowel prep had similar electrolyte changes to 4-L PEG but better taste and higher willingness to repeat.
Adding pidotimod plus vitamin C after laser vaporization showed a higher clinical clearance rate of warts (81% vs 67%) but the difference was not statistically significant.
Vitamin C supplementation did not prevent Depo-Provera-related menstrual irregularities or weight changes in adolescent girls.
Vitamin C supplementation did not prevent Depo-Provera-related menstrual irregularities or weight changes in adolescent girls.
Addition of L-ascorbic acid (with chitosan) for 8 weeks accentuated weight and BMI reduction compared with chitosan alone or placebo; BMI decrease was greater with ascorbic acid plus chitosan.
Vitamin C supplementation did not prevent Depo-Provera-related menstrual irregularities or weight changes in adolescent girls.
Peri- and postoperative vitamin C reduced subjective pain and analgesic use after hip fracture surgery but did not change hip function scores.
Adding topical magnesium ascorbyl phosphate (a vitamin C derivative) to TCA peels produced greater reduction in melasma severity than peel alone.
Adding topical magnesium ascorbyl phosphate (a vitamin C derivative) to TCA peels produced greater reduction in melasma severity than peel alone.
Vitamin C+E supplementation (with or without exercise) reduced oxidative stress markers and increased antioxidant measures in fibromyalgia patients, but symptoms did not improve.
Maternal vitamin C (500 mg/day) given to pregnant smokers improved newborn lung function and reduced wheezing through age 1 year.
Maternal vitamin C (500 mg/day) given to pregnant smokers improved newborn lung function and reduced wheezing through age 1 year.
Maternal vitamin C (500 mg/day) given to pregnant smokers improved newborn lung function and reduced wheezing through age 1 year.
Oral ascorbic acid around the time of coronary angiography reduced the incidence of contrast-induced nephropathy and attenuated the rise in serum creatinine.
Oral ascorbic acid around the time of coronary angiography reduced the incidence of contrast-induced nephropathy and attenuated the rise in serum creatinine.
In 31 patients, acute IV ascorbic acid (3 g) reversed cold-pressor-induced coronary vasoconstriction in chronic smokers.
An 8-month randomized double-blind placebo-controlled trial (n=138 completers) found no overall effect of 1 g/day vitamin C on HDL, LDL, total cholesterol or triglycerides; a small subgroup (n=43, low baseline AA) showed HDL +0.10 mmol/L.
In elderly patients, 2L PEG with ascorbic acid cleaned bowels as well as 4L PEG, with less liquid to drink and better tolerability.
In elderly patients, 2L PEG with ascorbic acid cleaned bowels as well as 4L PEG, with less liquid to drink and better tolerability.
In elderly patients, 2L PEG with ascorbic acid cleaned bowels as well as 4L PEG, with less liquid to drink and better tolerability.
In healthy volunteers, vitamin E supplementation markedly raised platelet alpha-tocopherol and reduced platelet function; vitamin C and beta-carotene showed no significant effects.
Double-blind randomized trial in 106 alcohol-dependent inpatients comparing 21 days of micronutrient supplementation (including zinc 20 mg) versus placebo and measuring serum vitamin and trace element levels.
In women with severe early pre-eclampsia, combined antioxidant therapy (including vitamin C) did not clearly improve biochemical markers or clinical prolongation of pregnancy.
In women with severe early pre-eclampsia, combined antioxidant therapy (including vitamin C) did not clearly improve biochemical markers or clinical prolongation of pregnancy.
A low-volume PEG–ascorbic acid (contains vitamin C) bowel prep (0.8 L) was as effective and safe as standard 2 L PEG–Asc for colonoscopy, with fewer bubbles and similar tolerability.
A low-volume PEG–ascorbic acid (contains vitamin C) bowel prep (0.8 L) was as effective and safe as standard 2 L PEG–Asc for colonoscopy, with fewer bubbles and similar tolerability.
A low-volume PEG–ascorbic acid (contains vitamin C) bowel prep (0.8 L) was as effective and safe as standard 2 L PEG–Asc for colonoscopy, with fewer bubbles and similar tolerability.
Vitamin C+E supplementation (with or without exercise) reduced oxidative stress markers and increased antioxidant measures in fibromyalgia patients, but symptoms did not improve.
Vitamin C+E supplementation (with or without exercise) reduced oxidative stress markers and increased antioxidant measures in fibromyalgia patients, but symptoms did not improve.
In postmenopausal women, daily antioxidant supplementation including 1000 mg vitamin C prevented the small lumbar spine bone loss seen in the placebo group over 6 months.
In 98 patients after rotator cuff repair, postoperative vitamin C (500 mg/day for 45 days) showed a non-significant trend toward lower non-healing rate at 6 months (11% vs 23%).
In 98 patients after rotator cuff repair, postoperative vitamin C (500 mg/day for 45 days) showed a non-significant trend toward lower non-healing rate at 6 months (11% vs 23%).
Short-term supplementation with vitamins C (500 mg/day) and E reduced exercise-induced oxidative stress in young football players but did not improve performance or reduce muscle soreness/damage.
Short-term supplementation with vitamins C (500 mg/day) and E reduced exercise-induced oxidative stress in young football players but did not improve performance or reduce muscle soreness/damage.
In colonoscopy patients, 1 L PEG with ascorbic acid was noninferior to 2 L for bowel cleansing but caused more thirst.
In colonoscopy patients, 1 L PEG with ascorbic acid was noninferior to 2 L for bowel cleansing but caused more thirst.
In colonoscopy patients, 1 L PEG with ascorbic acid was noninferior to 2 L for bowel cleansing but caused more thirst.
1 L PEG with ascorbic acid achieved similarly high adequate bowel-prep rates to oral sodium sulfate but caused more thirst and dizziness.
In cardiac transplant patients, vitamins C+E slowed early progression of coronary intimal thickening.
In cardiac transplant patients, vitamins C+E slowed early progression of coronary intimal thickening.
Randomized double-blind trial of daily multivitamin and trace element supplement (including zinc 20 mg) vs placebo in adults measuring serum nutrient levels and antioxidant markers over 6 months.
Randomized double-blind trial of daily multivitamin and trace element supplement (including zinc 20 mg) vs placebo in adults measuring serum nutrient levels and antioxidant markers over 6 months.
A double-blind trial in 100 volunteers tested a nitrite+ascorbic acid gel system (with/without lidocaine) and found the active formulation reduced pain during hand vein cannulation.
A double-blind trial in 100 volunteers tested a nitrite+ascorbic acid gel system (with/without lidocaine) and found the active formulation reduced pain during hand vein cannulation.
Fifty patients applied a serum containing 15% vitamin C to one side of the face after Fraxel laser; the vitamin-C–containing side showed less redness, lower erythema index, improved short-term hydration and less pain vs saline on the other side.
Fifty patients applied a serum containing 15% vitamin C to one side of the face after Fraxel laser; the vitamin-C–containing side showed less redness, lower erythema index, improved short-term hydration and less pain vs saline on the other side.
Fifty patients applied a serum containing 15% vitamin C to one side of the face after Fraxel laser; the vitamin-C–containing side showed less redness, lower erythema index, improved short-term hydration and less pain vs saline on the other side.
In 43 non-malnourished patients with severe pressure ulcers, a high-protein, arginine- and micronutrient-enriched oral supplement (which included vitamin C) accelerated ulcer healing and reduced dressing needs compared with control; blood vitamin C levels rose in the supplement group.
In 43 non-malnourished patients with severe pressure ulcers, a high-protein, arginine- and micronutrient-enriched oral supplement (which included vitamin C) accelerated ulcer healing and reduced dressing needs compared with control; blood vitamin C levels rose in the supplement group.
In 43 non-malnourished patients with severe pressure ulcers, a high-protein, arginine- and micronutrient-enriched oral supplement (which included vitamin C) accelerated ulcer healing and reduced dressing needs compared with control; blood vitamin C levels rose in the supplement group.
Providing 350 g/day vegetables and using water-free (multi-ply) cookware increased blood vitamin C and reduced oxidized LDL and LDL cholesterol over 2 weeks compared with ordinary cooking or usual diet.
Analysis of 146 men in an arterial imaging trial found no association between higher self-selected supplementary vitamin C intake (≥250 mg/day subgroup) and reduced carotid intima-media thickness progression.
In a 2×2 factorial RCT (n=99) adding vitamins E+C (including vitamin C ~1000 mg/day) to antipsychotics worsened psychotic positive symptoms in patients with low baseline RBC PUFA; combining vitamins with EPA neutralized the effect.
In a 2×2 factorial RCT (n=99) adding vitamins E+C (including vitamin C ~1000 mg/day) to antipsychotics worsened psychotic positive symptoms in patients with low baseline RBC PUFA; combining vitamins with EPA neutralized the effect.
In 131 patients with septic shock randomized to antioxidant arms, vitamin C treatment (oral 1 g q6h for 5 days) was associated with marked SOFA score improvement and reductions in some oxidative stress markers and inflammatory cytokines.
In 131 patients with septic shock randomized to antioxidant arms, vitamin C treatment (oral 1 g q6h for 5 days) was associated with marked SOFA score improvement and reductions in some oxidative stress markers and inflammatory cytokines.
In 61 AMI patients, supplementation with vitamins C and E (600 mg/day each) for 14 days prevented worsening of SAECG indices seen in controls and reduced leukocyte oxygen free radical production.
In 61 AMI patients, supplementation with vitamins C and E (600 mg/day each) for 14 days prevented worsening of SAECG indices seen in controls and reduced leukocyte oxygen free radical production.
An oral supplement containing lutein, zeaxanthin and coantioxidants (including vitamin C) produced functional and morphologic benefits in early AMD over 36 months.
An oral supplement containing lutein, zeaxanthin and coantioxidants (including vitamin C) produced functional and morphologic benefits in early AMD over 36 months.
An oral supplement containing lutein, zeaxanthin and coantioxidants (including vitamin C) produced functional and morphologic benefits in early AMD over 36 months.
Statin plus ascorbic acid reduced the incidence of post-contrast acute kidney injury compared to placebo, though serum creatinine and eGFR changes were not improved between groups.
A 6-month randomized trial found the product containing undenatured type II collagen (Artneo) improved pain, stiffness, and some MRI signs of synovitis and was not inferior to glucosamine+chondroitin.
A 6-month randomized trial found the product containing undenatured type II collagen (Artneo) improved pain, stiffness, and some MRI signs of synovitis and was not inferior to glucosamine+chondroitin.
Adding NAC and vitamin C did not significantly change urine IL-18 or NGAL or the incidence/duration of delayed graft function after living-donor kidney transplant in this trial.
Adding NAC and vitamin C did not significantly change urine IL-18 or NGAL or the incidence/duration of delayed graft function after living-donor kidney transplant in this trial.
Adding NAC and vitamin C did not significantly change urine IL-18 or NGAL or the incidence/duration of delayed graft function after living-donor kidney transplant in this trial.
In term infants with perinatal asphyxia, early intravenous ascorbic acid plus oral ibuprofen did not improve cytokines, mortality, neurologic discharge status, or 6-month developmental outcomes versus placebo.
In term infants with perinatal asphyxia, early intravenous ascorbic acid plus oral ibuprofen did not improve cytokines, mortality, neurologic discharge status, or 6-month developmental outcomes versus placebo.
Short-term vitamin C (2 g/day) plus high-dose vitamin E (800 IU/day) improved reactive hyperemia and reduced several inflammatory markers in smokers, whereas vitamin C alone was ineffective.
Short-term vitamin C (2 g/day) plus high-dose vitamin E (800 IU/day) improved reactive hyperemia and reduced several inflammatory markers in smokers, whereas vitamin C alone was ineffective.
A 2-L PEG solution containing ascorbic acid produced at least comparable bowel cleansing to sodium phosphate and was better tolerated.
A 2-L PEG solution containing ascorbic acid produced at least comparable bowel cleansing to sodium phosphate and was better tolerated.
1 L PEG with ascorbic acid achieved similarly high adequate bowel-prep rates to oral sodium sulfate but caused more thirst and dizziness.
1 L PEG with ascorbic acid achieved similarly high adequate bowel-prep rates to oral sodium sulfate but caused more thirst and dizziness.
Strength training reduced perceived and performance fatigue in breast cancer survivors; adding vitamins C (500 mg/day) and E gave no additional benefit.
Strength training reduced perceived and performance fatigue in breast cancer survivors; adding vitamins C (500 mg/day) and E gave no additional benefit.
Strength training reduced perceived and performance fatigue in breast cancer survivors; adding vitamins C (500 mg/day) and E gave no additional benefit.
High‑dose IV and short-term oral ascorbic acid did not reduce serum creatinine rise or incidence of contrast-induced nephropathy in patients with renal insufficiency undergoing coronary angiography.
High‑dose IV and short-term oral ascorbic acid did not reduce serum creatinine rise or incidence of contrast-induced nephropathy in patients with renal insufficiency undergoing coronary angiography.
Over 72 months, cure of H. pylori improved gastric antral atrophy; dietary ascorbic acid supplementation showed no significant independent effect.
In young men undergoing intense endurance training, antioxidant supplementation (vitamin C 500 mg + vitamin E) did not alter the training-induced increase in insulin sensitivity or improvements in fitness.
In young men undergoing intense endurance training, antioxidant supplementation (vitamin C 500 mg + vitamin E) did not alter the training-induced increase in insulin sensitivity or improvements in fitness.
In elderly patients with type 2 diabetes, vitamin C (0.5–1 g/day) increased cellular glutathione and LDL vitamin E content but did not reduce LDL susceptibility to peroxidation.
In elderly patients with type 2 diabetes, vitamin C (0.5–1 g/day) increased cellular glutathione and LDL vitamin E content but did not reduce LDL susceptibility to peroxidation.
In elderly patients with type 2 diabetes, vitamin C (0.5–1 g/day) increased cellular glutathione and LDL vitamin E content but did not reduce LDL susceptibility to peroxidation.
Elderly stroke patients received ascorbic acid or Cytoflavin; vitamin C showed no morphologic benefit.
In ischemic stroke patients, ascorbic acid showed no effect on ischemic lesion volume or morphologic parameters, whereas cytoflavin produced volume reductions and better clinical outcomes.
Elderly stroke patients received ascorbic acid or Cytoflavin; vitamin C showed no morphologic benefit.
In ischemic stroke patients, ascorbic acid showed no effect on ischemic lesion volume or morphologic parameters, whereas cytoflavin produced volume reductions and better clinical outcomes.
A mobile intervention or providing fruits/vegetables increased daily intake (~+0.9 servings/day) and raised plasma vitamin C compared to control in young adults.
A multi‑component product that includes caffeine improved common‑cold symptom scores more than controls, though caffeine was not tested alone.
High‑dose sustained‑release vitamin C for 14 days reduced BP reactivity and subjective stress and sped cortisol recovery during an acute laboratory stress test.
High‑dose sustained‑release vitamin C for 14 days reduced BP reactivity and subjective stress and sped cortisol recovery during an acute laboratory stress test.
High‑dose sustained‑release vitamin C for 14 days reduced BP reactivity and subjective stress and sped cortisol recovery during an acute laboratory stress test.
After 2 years of daily antioxidant supplementation (including 120 mg vitamin C), plasma concentrations of vitamin C, vitamin E, beta-carotene, selenium and zinc were significantly higher than placebo in a 1000-person subsample.
Chlorella supplementation increased plasma vitamin C and other antioxidant markers and improved erythrocyte antioxidant enzymes in smokers, though DNA damage also decreased with placebo.
Chlorella supplementation increased plasma vitamin C and other antioxidant markers and improved erythrocyte antioxidant enzymes in smokers, though DNA damage also decreased with placebo.
Smokers had smaller, more superficial punch wounds and lower vitamin C and PINP (a collagen synthesis marker); smoking cessation increased wound depth, vitamin C, and PINP; nicotine patch had no detectable effect.
Smokers had smaller, more superficial punch wounds and lower vitamin C and PINP (a collagen synthesis marker); smoking cessation increased wound depth, vitamin C, and PINP; nicotine patch had no detectable effect.
An antioxidant supplement regimen including vitamin C reduced exercise-induced oxidative stress and improved adiponectin and some inflammatory/lipid responses in overweight young adults.
An antioxidant supplement regimen including vitamin C reduced exercise-induced oxidative stress and improved adiponectin and some inflammatory/lipid responses in overweight young adults.
An antioxidant supplement regimen including vitamin C reduced exercise-induced oxidative stress and improved adiponectin and some inflammatory/lipid responses in overweight young adults.
In adolescent girls with metabolic syndrome, 6 weeks of DASH recommendations increased vitamin C levels, lowered insulin and prevented rise in diastolic blood pressure versus usual advice.
In adolescent girls with metabolic syndrome, 6 weeks of DASH recommendations increased vitamin C levels, lowered insulin and prevented rise in diastolic blood pressure versus usual advice.
Four years after a community dietary program, participants largely maintained a low-salt, high-carotene and high–vitamin C diet compared with pre-intervention.
In people with type 2 diabetes, 8 weeks of 500 mg/day vitamin C raised leptin and restored a significant leptin–CRP correlation compared with placebo.
In people with type 2 diabetes, 8 weeks of 500 mg/day vitamin C raised leptin and restored a significant leptin–CRP correlation compared with placebo.
In people with type 2 diabetes, 8 weeks of 500 mg/day vitamin C raised leptin and restored a significant leptin–CRP correlation compared with placebo.
After H. pylori eradication, 6 months of 500 mg/day ascorbic acid led to greater regression of gastric intestinal metaplasia versus no treatment.
After H. pylori eradication, 6 months of 500 mg/day ascorbic acid led to greater regression of gastric intestinal metaplasia versus no treatment.
Perioperative vitamin C supplementation reduced incidence of postoperative atrial fibrillation and shortened hospital and ICU stays compared with control.
In patients with renal impairment undergoing angiography, high-dose ascorbic acid produced a small rise in creatinine and tended to higher CIN rates compared with high-dose NAC; diabetics on ascorbic acid had higher CIN.
In patients with renal impairment undergoing angiography, high-dose ascorbic acid produced a small rise in creatinine and tended to higher CIN rates compared with high-dose NAC; diabetics on ascorbic acid had higher CIN.
In CKD patients having catheterization, IV sodium bicarbonate plus IV ascorbic acid reduced contrast-induced kidney injury versus saline.
A 4-month high-antioxidant diet (designed to raise vitamins A, C and E) increased plasma and leukocyte vitamin C, boosted antioxidant enzyme activities, and lowered lipid oxidative markers in women with endometriosis.
Six-month double-blind RCT in institutionalized elderly: vitamin supplementation (including vitamin C) increased serum vitamin levels and improved enzymatic antioxidant activity.
Large randomized trial of vitamin C (1000 mg) plus vitamin E vs placebo in pregnancy found no reduction in preeclampsia or major perinatal adverse outcomes.
Large randomized trial of vitamin C (1000 mg) plus vitamin E vs placebo in pregnancy found no reduction in preeclampsia or major perinatal adverse outcomes.
Large randomized trial of vitamin C (1000 mg) plus vitamin E vs placebo in pregnancy found no reduction in preeclampsia or major perinatal adverse outcomes.
Doubling antioxidant intake via supplements (including vitamin C) or foods for 8 weeks did not change measured inflammatory markers in adults at CVD risk.
Doubling antioxidant intake via supplements (including vitamin C) or foods for 8 weeks did not change measured inflammatory markers in adults at CVD risk.
Doubling antioxidant intake via supplements (including vitamin C) or foods for 8 weeks did not change measured inflammatory markers in adults at CVD risk.
In CHD patients over 30 days, vitamin C (1,000 mg) reduced lipid peroxide (TBARS) but did not change lipid concentrations.
In CHD patients over 30 days, vitamin C (1,000 mg) reduced lipid peroxide (TBARS) but did not change lipid concentrations.
Higher maternal dietary vitamin C in pregnancy was associated with lower risk of infant wheeze at 1 year; no protective effect was seen for total vitamin C intake including supplements.
Higher maternal dietary vitamin C in pregnancy was associated with lower risk of infant wheeze at 1 year; no protective effect was seen for total vitamin C intake including supplements.
A fruit/vegetable purée drink acutely raised plasma vitamin C and plasma antioxidant capacity and showed a trend toward improved endothelium-dependent vasodilation.
Oral ascorbic acid markedly raised plasma ascorbate levels but did not improve brachial artery flow‑mediated (endothelium-dependent) dilation in hypertensive patients; chronic treatment previously reported to lower blood pressure.
Oral ascorbic acid markedly raised plasma ascorbate levels but did not improve brachial artery flow‑mediated (endothelium-dependent) dilation in hypertensive patients; chronic treatment previously reported to lower blood pressure.
Combined antioxidant supplementation including 500 mg/day vitamin C for 2–4 months had no significant effect on blood pressure, serum lipids or fasting glucose in older adults.
Combined antioxidant supplementation including 500 mg/day vitamin C for 2–4 months had no significant effect on blood pressure, serum lipids or fasting glucose in older adults.
Combined antioxidant supplementation including 500 mg/day vitamin C for 2–4 months had no significant effect on blood pressure, serum lipids or fasting glucose in older adults.
Three months of community yoga lowered oxidative stress (MDA) and improved BMI, waist, systolic BP and fasting glucose but did not change vitamin C levels.
Adding guava to a supplemental meal increased vitamin C and improved iron status in preschoolers; the study measured B12 but did not report a B12 effect.
In patients with schizophrenia, vitamins E+C (including vitamin C 1000 mg/day) impaired sustained attention in a subgroup and produced adverse neurocognitive effects unless combined with ethyl‑EPA.
In patients with schizophrenia, vitamins E+C (including vitamin C 1000 mg/day) impaired sustained attention in a subgroup and produced adverse neurocognitive effects unless combined with ethyl‑EPA.
A single 2 g oral vitamin C given 1 hour before major abdominal surgery reduced pain scores, lowered morphine use, and decreased need for extra analgesic compared with placebo.
A single 2 g oral vitamin C given 1 hour before major abdominal surgery reduced pain scores, lowered morphine use, and decreased need for extra analgesic compared with placebo.
Intraoperative antioxidant infusion containing tocopherol and ascorbate attenuated the immediate rise in lipid-peroxidation marker after reperfusion and improved prothrombin time.
Intraoperative antioxidant infusion containing tocopherol and ascorbate attenuated the immediate rise in lipid-peroxidation marker after reperfusion and improved prothrombin time.
Randomized, triple‑blind trial of perioperative ascorbic acid vs placebo in CABG patients; monitored postoperative atrial fibrillation and complications.
Intraoperative antioxidant infusion containing tocopherol and ascorbate attenuated the immediate rise in lipid-peroxidation marker after reperfusion and improved prothrombin time.
Long-term low-dose combined antioxidant supplementation (including 120 mg vitamin C) showed no benefit on carotid intima-media thickness or arterial stiffness and had a higher proportion of carotid plaques in the intervention group.
Long-term low-dose combined antioxidant supplementation (including 120 mg vitamin C) showed no benefit on carotid intima-media thickness or arterial stiffness and had a higher proportion of carotid plaques in the intervention group.
Long-term low-dose combined antioxidant supplementation (including 120 mg vitamin C) showed no benefit on carotid intima-media thickness or arterial stiffness and had a higher proportion of carotid plaques in the intervention group.
In this secondary analysis of the ATBC trial, vitamin E extended lifespan in older men (≥71 years) and particularly in the subgroup with higher dietary vitamin C intake who smoked <1 pack/day.
In this secondary analysis of the ATBC trial, vitamin E extended lifespan in older men (≥71 years) and particularly in the subgroup with higher dietary vitamin C intake who smoked <1 pack/day.
In adults with stable asthma, 1000 mg/day vitamin C for 1 month increased leukocyte vitamin C levels but did not improve lung function.
In adults with stable asthma, 1000 mg/day vitamin C for 1 month increased leukocyte vitamin C levels but did not improve lung function.
Randomized trial comparing 2L PEG+ascorbic acid versus 4L PEG for colon capsule prep found similar cleansing but higher capsule excretion rate with the ascorbic-acid regimen.
Randomized trial comparing 2L PEG+ascorbic acid versus 4L PEG for colon capsule prep found similar cleansing but higher capsule excretion rate with the ascorbic-acid regimen.
In chronic bronchitis patients, 500 mg vitamin C twice daily (alone or with NAC) for 3 months did not reduce inflammatory cell ROS release, change glutathione, or improve symptoms/ spirometry.
In chronic bronchitis patients, 500 mg vitamin C twice daily (alone or with NAC) for 3 months did not reduce inflammatory cell ROS release, change glutathione, or improve symptoms/ spirometry.
In chronic bronchitis patients, 500 mg vitamin C twice daily (alone or with NAC) for 3 months did not reduce inflammatory cell ROS release, change glutathione, or improve symptoms/ spirometry.
High-dose IV vitamin C after cardiac surgery was feasible and safe but did not significantly speed resolution of vasoplegia.
High-dose IV vitamin C after cardiac surgery was feasible and safe but did not significantly speed resolution of vasoplegia.
High-dose IV vitamin C after cardiac surgery was feasible and safe but did not significantly speed resolution of vasoplegia.
Double-blind randomized trial giving high-dose IV and cardioplegia vitamin C in CABG patients found no change in cardiac enzymes but improved ejection fraction and shorter ICU stay.
In older women doing 6 weeks of moderate training, 1000 mg/day vitamin C raised blood vitamin C but did not produce clear changes in antioxidant balance or inflammatory gene expression.
In older women doing 6 weeks of moderate training, 1000 mg/day vitamin C raised blood vitamin C but did not produce clear changes in antioxidant balance or inflammatory gene expression.
A low-volume PEG solution containing ascorbic acid provided effective bowel cleansing and better proximal colon cleansing versus comparator in this pilot study.
In autologous SCT patients, vitamin C supplementation raised serum vitamin C but did not shorten time to neutrophil recovery; transient higher cytotoxic T cells and a lower (non-significant) bacteremia rate were observed.
In autologous SCT patients, vitamin C supplementation raised serum vitamin C but did not shorten time to neutrophil recovery; transient higher cytotoxic T cells and a lower (non-significant) bacteremia rate were observed.
In outpatients undergoing colonoscopy, low-volume PEG with vitamin C gave similar overall cleansing and mucosal injury rates but more residual colonic fluid and better patient acceptance.
In outpatients undergoing colonoscopy, low-volume PEG with vitamin C gave similar overall cleansing and mucosal injury rates but more residual colonic fluid and better patient acceptance.
In outpatients undergoing colonoscopy, low-volume PEG with vitamin C gave similar overall cleansing and mucosal injury rates but more residual colonic fluid and better patient acceptance.
In outpatients undergoing colonoscopy, low-volume PEG with vitamin C gave similar overall cleansing and mucosal injury rates but more residual colonic fluid and better patient acceptance.
In 30 HCV patients, adding black cumin and vitamin C to standard antivirals showed small improvements in hematologic and antioxidant markers and a significant drop in fasting glucose, but most comparisons were not statistically significant.
In 30 HCV patients, adding black cumin and vitamin C to standard antivirals showed small improvements in hematologic and antioxidant markers and a significant drop in fasting glucose, but most comparisons were not statistically significant.
In 30 HCV patients, adding black cumin and vitamin C to standard antivirals showed small improvements in hematologic and antioxidant markers and a significant drop in fasting glucose, but most comparisons were not statistically significant.
In 25 men, daily blond orange juice produced a marked antioxidant effect (linked to hesperetin) and trends toward improved endothelial function and modest apoA-I increase compared with a control beverage that contained vitamin C but lacked phytomicronutrients.
In 25 men, daily blond orange juice produced a marked antioxidant effect (linked to hesperetin) and trends toward improved endothelial function and modest apoA-I increase compared with a control beverage that contained vitamin C but lacked phytomicronutrients.
In 25 men, daily blond orange juice produced a marked antioxidant effect (linked to hesperetin) and trends toward improved endothelial function and modest apoA-I increase compared with a control beverage that contained vitamin C but lacked phytomicronutrients.
IV vitamin C plus thiamine in early septic shock did not change prognostic biomarker levels (IL-6, IL-10, angiopoietin-II, S100β) at 72 hours.
IV vitamin C plus thiamine in early septic shock did not change prognostic biomarker levels (IL-6, IL-10, angiopoietin-II, S100β) at 72 hours.
IV vitamin C plus thiamine in early septic shock did not change prognostic biomarker levels (IL-6, IL-10, angiopoietin-II, S100β) at 72 hours.
In a controlled crossover study (24 subjects across three groups), acute vitamin C infusion improved acetylcholine-mediated endothelial responses in type 1 diabetes patients and regular smokers.
Controlled exposure to fine particulates (± ozone) increased diastolic blood pressure and, in one location, impaired endothelial function; high-dose vitamin C (2 g) pretreatment did not prevent the BP rise or endothelial impairment.
Adding orange juice to PEG–ascorbic acid bowel prep improved taste and reduced nausea without reducing cleansing efficacy.
Adding oral vitamin C to standard saline hydration did not significantly reduce contrast-induced kidney injury compared with hydration alone.
Adding oral vitamin C to standard saline hydration did not significantly reduce contrast-induced kidney injury compared with hydration alone.
Daily vitamins E+C for 1 year improved antioxidant biomarkers but did not improve cognitive test scores in elderly with mild cognitive impairment.
Daily vitamins E+C for 1 year improved antioxidant biomarkers but did not improve cognitive test scores in elderly with mild cognitive impairment.
Daily oral iron plus vitamin C for ~30 days prevented hemoglobin loss in older adults awaiting orthopedic surgery; overall effects in the whole cohort were limited.
Daily oral iron plus vitamin C for ~30 days prevented hemoglobin loss in older adults awaiting orthopedic surgery; overall effects in the whole cohort were limited.
In moderately trained men, 2 weeks of vitamin C (1000 mg/day) plus vitamin E reduced quadriceps soreness and markers of muscle damage and increased antioxidant capacity after repeated downhill runs.
In moderately trained men, 2 weeks of vitamin C (1000 mg/day) plus vitamin E reduced quadriceps soreness and markers of muscle damage and increased antioxidant capacity after repeated downhill runs.
In moderately trained men, 2 weeks of vitamin C (1000 mg/day) plus vitamin E reduced quadriceps soreness and markers of muscle damage and increased antioxidant capacity after repeated downhill runs.
In healthy adults, serum vitamin C concentrations differed by GST genotype and were associated with differences in oxidative stress biomarkers.
In healthy adults, serum vitamin C concentrations differed by GST genotype and were associated with differences in oxidative stress biomarkers.
In 51 high‑risk premature infants, daily ascorbic acid (100 mg/kg) during the first week prevented the normal postnatal drop in levels and was not associated with increased hemolysis or short‑term adverse outcomes.
In 51 high‑risk premature infants, daily ascorbic acid (100 mg/kg) during the first week prevented the normal postnatal drop in levels and was not associated with increased hemolysis or short‑term adverse outcomes.
Cross‑sectional baseline data from 159 urban African Americans with uncontrolled hypertension showed overall vitamin C intake higher than recommendations, but below‑median intake was associated with greater albuminuria.
Cross‑sectional baseline data from 159 urban African Americans with uncontrolled hypertension showed overall vitamin C intake higher than recommendations, but below‑median intake was associated with greater albuminuria.
In calcium stone formers, vitamin C intake correlated with urinary oxalate excretion; an oxalate food load without calcium raised urinary oxalate by ~20%.
In calcium stone formers, vitamin C intake correlated with urinary oxalate excretion; an oxalate food load without calcium raised urinary oxalate by ~20%.
In a randomized crossover trial of overweight/obese adolescents (58 completers), an anti-inflammatory supplement containing vitamin C maintained high-molecular-weight adiponectin but did not change insulin resistance overall; a subgroup (n=23) showed ≥10% improvement in HOMA-IR.
In children with NAFLD, adding vitamin E plus vitamin C to diet/exercise did not improve liver enzymes, insulin resistance, or weight loss compared with placebo.
A combined nutraceutical containing bergamot extract and phytosterols improved triglycerides, LDL-C, and insulin resistance markers versus placebo in overweight dyslipidemic subjects.
In type 2 diabetic men on metformin, daily vitamin C (alone or with vitamin E) for 90 days improved glycemic control, insulin resistance measures, and some oxidative stress markers versus placebo.
In children with NAFLD, adding vitamin E plus vitamin C to diet/exercise did not improve liver enzymes, insulin resistance, or weight loss compared with placebo.
Secondary analysis of a prenatal vitamin C+E trial: maternal adiponectin at delivery was slightly higher with vitamins overall, while cord blood adiponectin did not differ; effects varied by baseline adiponectin tertile.
Secondary analysis of a prenatal vitamin C+E trial: maternal adiponectin at delivery was slightly higher with vitamins overall, while cord blood adiponectin did not differ; effects varied by baseline adiponectin tertile.
Secondary analysis of a prenatal vitamin C+E trial: maternal adiponectin at delivery was slightly higher with vitamins overall, while cord blood adiponectin did not differ; effects varied by baseline adiponectin tertile.
Antioxidant vitamins, with or without B-group vitamins (including B12), improved antioxidant capacity, lowered oxidative damage markers and reduced CRP after acute ischemic stroke; B vitamins reduced homocysteine.
Antioxidant vitamins, with or without B-group vitamins (including B12), improved antioxidant capacity, lowered oxidative damage markers and reduced CRP after acute ischemic stroke; B vitamins reduced homocysteine.
A randomized double-blind trial found a single 3 g IV vitamin C dose at induction reduced 0–24 h morphine use, early VAS pain scores, early IL-6 and CRP, and improved early hip flexion after total hip arthroplasty.
A randomized double-blind trial found a single 3 g IV vitamin C dose at induction reduced 0–24 h morphine use, early VAS pain scores, early IL-6 and CRP, and improved early hip flexion after total hip arthroplasty.
Daily antioxidant capsule containing 20 mg zinc (among other antioxidants) for 7.5 years had no effect on fasting plasma glucose compared with placebo.
Daily antioxidant capsule containing 20 mg zinc (among other antioxidants) for 7.5 years had no effect on fasting plasma glucose compared with placebo.
Multicenter randomized trial comparing PEG with ascorbic acid versus oral sulfate solution for colonoscopy bowel prep; no difference in success rates, slightly less vomiting intensity with PEG+ascorbic acid.
Multicenter randomized trial comparing PEG with ascorbic acid versus oral sulfate solution for colonoscopy bowel prep; no difference in success rates, slightly less vomiting intensity with PEG+ascorbic acid.
Randomized single-blind trial in patients with melasma found both treatments reduced severity; hydroquinone+ascorbic acid gave greater melanin index reduction.
Randomized, blinded trial in older adults with tinnitus tested several antioxidant regimens (one included vitamin C) and found no significant benefit on tinnitus scores after six months.
Randomized, blinded trial in older adults with tinnitus tested several antioxidant regimens (one included vitamin C) and found no significant benefit on tinnitus scores after six months.
Randomized clinical trial in off-pump CABG patients found perioperative oral vitamin C (with other arms) did not reduce incidence or severity of acute kidney injury or related morbidity.
Vitamin C (1000 mg) plus vitamin E given from 16–22 weeks reduced markers of placental dysfunction and lowered pre-eclampsia risk in high‑risk women.
Vitamin C (1000 mg) plus vitamin E given from 16–22 weeks reduced markers of placental dysfunction and lowered pre-eclampsia risk in high‑risk women.
A twice-daily enriched drink increased plasma antioxidant levels including vitamin C in frail elderly people over six months.
1 L PEG plus ascorbate achieved higher overall and right‑colon cleansing success than 4 L PEG with similar tolerability and safety.
1 L PEG plus ascorbate achieved higher overall and right‑colon cleansing success than 4 L PEG with similar tolerability and safety.
In chronic hemodialysis patients, supplementation including vitamin C (250 mg) and vitamin E with whey protein reduced IL‑10 after 8 weeks; other inflammatory markers showed no significant between‑group changes.
High-dose vitamins C+E raised serum vitamin levels but unexpectedly increased markers of haemolysis without improving haemoglobin in sickle cell patients.
High-dose vitamins C+E raised serum vitamin levels but unexpectedly increased markers of haemolysis without improving haemoglobin in sickle cell patients.
An intensive dietary program that increased vitamin C intake (among other changes) improved iron intake and produced modest increases in iron stores compared with placebo, while iron supplementation produced larger increases.
Daily fruit-and-vegetable puree drinks raised dietary vitamin C and plasma carotenoids and produced a trend toward improved endothelium-dependent vasodilation.
Adding oral antioxidants (including vitamin C) to intranasal steroid treatment reduced tissue and serum oxidative marker levels more than steroid alone in patients with nasal polyps.
Adding oral antioxidants (including vitamin C) to intranasal steroid treatment reduced tissue and serum oxidative marker levels more than steroid alone in patients with nasal polyps.
Adding oral antioxidants (including vitamin C) to intranasal steroid treatment reduced tissue and serum oxidative marker levels more than steroid alone in patients with nasal polyps.
In 60 children with septic shock, IV vitamin C plus hydrocortisone and thiamin was feasible to deliver but did not improve organ-dysfunction-free days and showed a numerically higher 28-day mortality.
In 60 children with septic shock, IV vitamin C plus hydrocortisone and thiamin was feasible to deliver but did not improve organ-dysfunction-free days and showed a numerically higher 28-day mortality.
In 341 outpatients with physical disabilities, an ascorbic acid–enriched PEG solution produced adequate bowel cleansing in most patients; an alternative low-volume prep was noninferior and safety was similar.
In 341 outpatients with physical disabilities, an ascorbic acid–enriched PEG solution produced adequate bowel cleansing in most patients; an alternative low-volume prep was noninferior and safety was similar.
In 341 outpatients with physical disabilities, an ascorbic acid–enriched PEG solution produced adequate bowel cleansing in most patients; an alternative low-volume prep was noninferior and safety was similar.
In 336 adults with distal radial fractures, 500 mg daily vitamin C for 50 days did not improve functional outcome at one year and showed some early subgroup harms.
In 336 adults with distal radial fractures, 500 mg daily vitamin C for 50 days did not improve functional outcome at one year and showed some early subgroup harms.
In 336 adults with distal radial fractures, 500 mg daily vitamin C for 50 days did not improve functional outcome at one year and showed some early subgroup harms.
In 184 nonsmokers, 500 mg vitamin C daily reduced a marker of lipid peroxidation and increased antioxidant capacity, with no added benefit from combining vitamins C and E.
In 184 nonsmokers, 500 mg vitamin C daily reduced a marker of lipid peroxidation and increased antioxidant capacity, with no added benefit from combining vitamins C and E.
In 184 nonsmokers, 500 mg vitamin C daily reduced a marker of lipid peroxidation and increased antioxidant capacity, with no added benefit from combining vitamins C and E.
In 122 premenopausal women, a high fruit-and-vegetable dietary intervention significantly increased plasma vitamin C and other carotenoids over one year.
In 122 premenopausal women, a high fruit-and-vegetable dietary intervention significantly increased plasma vitamin C and other carotenoids over one year.
In 44 men with moderate-to-severe COPD, an 8-week fortified whey beverage containing 275 mg elemental magnesium improved inflammation, fat-free mass, muscle strength, and respiratory-quality-of-life measures versus control.
In 44 men with moderate-to-severe COPD, an 8-week fortified whey beverage containing 275 mg elemental magnesium improved inflammation, fat-free mass, muscle strength, and respiratory-quality-of-life measures versus control.
In 44 men with moderate-to-severe COPD, an 8-week fortified whey beverage containing 275 mg elemental magnesium improved inflammation, fat-free mass, muscle strength, and respiratory-quality-of-life measures versus control.
Large randomized trial in older male physicians found daily 500 mg vitamin C had no effect on risk of age-related cataract over 8 years.
Healthy volunteers given LPS showed impaired retinal vascular reactivity that was normalized after 2 weeks of AREDS antioxidants (which include vitamin C) but not after placebo.
Healthy volunteers given LPS showed impaired retinal vascular reactivity that was normalized after 2 weeks of AREDS antioxidants (which include vitamin C) but not after placebo.
Adding orange juice to PEG–ascorbic acid bowel prep improved taste and reduced nausea without reducing cleansing efficacy.
Adding orange juice to PEG–ascorbic acid bowel prep improved taste and reduced nausea without reducing cleansing efficacy.
Antioxidant supplementation including vitamin C (1000 mg/day) prevented the exercise-induced decrease in serum vaspin seen without antioxidants after 4 weeks of training.
Antioxidant supplementation including vitamin C (1000 mg/day) prevented the exercise-induced decrease in serum vaspin seen without antioxidants after 4 weeks of training.
In type 2 diabetic men on metformin, daily vitamin C (alone or with vitamin E) for 90 days improved glycemic control, insulin resistance measures, and some oxidative stress markers versus placebo.
In healthy female volunteers, ascorbic acid (500 mg) increased intestinal permeability (lactulose excretion) more than aspirin alone and had an additive effect when combined with aspirin.
In healthy female volunteers, ascorbic acid (500 mg) increased intestinal permeability (lactulose excretion) more than aspirin alone and had an additive effect when combined with aspirin.
In outpatients undergoing colonoscopy, PEG plus ascorbic acid provided similar bowel cleansing efficacy to picosulphate/magnesium citrate but had lower tolerability and willingness-to-repeat.
In outpatients undergoing colonoscopy, PEG plus ascorbic acid provided similar bowel cleansing efficacy to picosulphate/magnesium citrate but had lower tolerability and willingness-to-repeat.
Bowel prep containing ascorbic acid cleaned the colon better and led to more adenomas being detected, with similar tolerability.
Randomized open-label trial in asymptomatic COVID-19 patients comparing KSK decoction to standard care (vitamin C + zinc) for 7 days; measured viral load and cytokines.
Randomized open-label trial in asymptomatic COVID-19 patients comparing KSK decoction to standard care (vitamin C + zinc) for 7 days; measured viral load and cytokines.
Randomized open-label trial in asymptomatic COVID-19 patients comparing KSK decoction to standard care (vitamin C + zinc) for 7 days; measured viral load and cytokines.
Feasibility randomized, blinded study of IV ascorbic acid (300 mg or 600 mg thrice weekly) vs placebo after angioplasty in hemodialysis access patients; angiographic and clinical restenosis assessed.
Feasibility randomized, blinded study of IV ascorbic acid (300 mg or 600 mg thrice weekly) vs placebo after angioplasty in hemodialysis access patients; angiographic and clinical restenosis assessed.
Feasibility randomized, blinded study of IV ascorbic acid (300 mg or 600 mg thrice weekly) vs placebo after angioplasty in hemodialysis access patients; angiographic and clinical restenosis assessed.
Oral ascorbic acid (500 mg every 8 hours) did not prevent or reduce tooth sensitivity after bleaching.
Oral ascorbic acid (500 mg every 8 hours) did not prevent or reduce tooth sensitivity after bleaching.
Oral ascorbic acid (500 mg every 8 hours) did not prevent or reduce tooth sensitivity after bleaching.
A high-antioxidant diet increased dietary vitamin C intake and was associated with reduced CRP and some liver enzymes but no broad changes in oxidative stress markers.
A high-antioxidant diet increased dietary vitamin C intake and was associated with reduced CRP and some liver enzymes but no broad changes in oxidative stress markers.
In surgical patients on TPN, plasma vitamin C and other non-supplemented antioxidants fell during TPN despite alpha-tocopherol supplementation normalizing tocopherol levels in one group.
A 2-year RCT of combined antioxidants including vitamin C showed no improvement or stabilization of cognitive decline in individuals with Down syndrome and dementia.
Critically ill patients receiving enteral formula enriched with vitamins A, C, and E showed increased plasma antioxidant vitamins and improved LDL resistance to oxidation, with no change in clinical outcomes.
A high-antioxidant diet increased dietary vitamin C intake and was associated with reduced CRP and some liver enzymes but no broad changes in oxidative stress markers.
Pregnant women with gestational diabetes given 1 g/day vitamin C needed less insulin and had improved placental oxidative markers and better neonatal glucose and fewer NICU admissions.
Pregnant women with gestational diabetes given 1 g/day vitamin C needed less insulin and had improved placental oxidative markers and better neonatal glucose and fewer NICU admissions.
Pregnant women with gestational diabetes given 1 g/day vitamin C needed less insulin and had improved placental oxidative markers and better neonatal glucose and fewer NICU admissions.
In elderly adults, 4 weeks of vitamin C supplementation reduced the adverse association between certain perfluorinated compounds and insulin resistance.
In elderly adults, 4 weeks of vitamin C supplementation reduced the adverse association between certain perfluorinated compounds and insulin resistance.
1 L polyethylene glycol with ascorbic acid plus a low-residue diet provided similar or better bowel cleansing and greater patient satisfaction than 2 L PEGA.
1 L polyethylene glycol with ascorbic acid plus a low-residue diet provided similar or better bowel cleansing and greater patient satisfaction than 2 L PEGA.
In a small randomized phase 2 trial, adding high‑dose IV vitamin C to standard chemotherapy improved survival and reduced some chemotherapy toxicities.
In a small randomized phase 2 trial, adding high‑dose IV vitamin C to standard chemotherapy improved survival and reduced some chemotherapy toxicities.
In a small randomized phase 2 trial, adding high‑dose IV vitamin C to standard chemotherapy improved survival and reduced some chemotherapy toxicities.
In the ATBC cohort of male smokers, higher dietary vitamin C was linked to lower tuberculosis risk; vitamin C intake modified the effect of vitamin E supplementation.
In the ATBC cohort of male smokers, higher dietary vitamin C was linked to lower tuberculosis risk; vitamin C intake modified the effect of vitamin E supplementation.
Close dietetic supervision of a Mediterranean-style diet increased antioxidant intake, including vitamin C, and raised plasma antioxidant capacity over 2 months.
Close dietetic supervision of a Mediterranean-style diet increased antioxidant intake, including vitamin C, and raised plasma antioxidant capacity over 2 months.
Ascorbic acid strongly enhanced iron absorption from FeSO4 but had a smaller effect on poorly soluble electrolytic iron in human volunteers.
Ascorbic acid strongly enhanced iron absorption from FeSO4 but had a smaller effect on poorly soluble electrolytic iron in human volunteers.
Ascorbic acid strongly enhanced iron absorption from FeSO4 but had a smaller effect on poorly soluble electrolytic iron in human volunteers.
Daily antioxidant supplement including 1 g vitamin C did not reduce incidence or severity of acute mountain sickness in healthy volunteers at high altitude.
Daily antioxidant supplement including 1 g vitamin C did not reduce incidence or severity of acute mountain sickness in healthy volunteers at high altitude.
Adding high-dose multiple antioxidants (including ~6100 mg/day vitamin C) to chemotherapy showed no statistically significant improvement in response rate or survival in advanced NSCLC.
Adding high-dose multiple antioxidants (including ~6100 mg/day vitamin C) to chemotherapy showed no statistically significant improvement in response rate or survival in advanced NSCLC.
Adding high-dose multiple antioxidants (including ~6100 mg/day vitamin C) to chemotherapy showed no statistically significant improvement in response rate or survival in advanced NSCLC.
Eating gold kiwifruit daily increased plasma vitamin C and some antioxidants and reduced duration/severity of selected cold symptoms in older adults.
Eating gold kiwifruit daily increased plasma vitamin C and some antioxidants and reduced duration/severity of selected cold symptoms in older adults.
Low-volume PEG+ascorbic acid provided similarly adequate bowel cleansing to high-volume PEG+simethicone but had worse bowel wall visualization and slightly fewer small adenoma detections.
Low-volume PEG+ascorbic acid provided similarly adequate bowel cleansing to high-volume PEG+simethicone but had worse bowel wall visualization and slightly fewer small adenoma detections.
Low-volume PEG+ascorbic acid provided similarly adequate bowel cleansing to high-volume PEG+simethicone but had worse bowel wall visualization and slightly fewer small adenoma detections.
Chronic periodontitis patients had lower plasma total antioxidant capacity than controls; non-surgical periodontal therapy reduced oxidative stress, and adjunctive vitamin C showed no clear additional benefit in this small study.
Chronic periodontitis patients had lower plasma total antioxidant capacity than controls; non-surgical periodontal therapy reduced oxidative stress, and adjunctive vitamin C showed no clear additional benefit in this small study.
In CAD patients, folic acid supplementation markedly raised plasma folate and produced a modest homocysteine fall and a significant improvement in flow-mediated dilation versus placebo; adding antioxidants did not produce significant additional benefit.
Giving low consumers ~480 g/day fruit/veg + up to 300 ml juice for 12 weeks raised blood vitamin C and other nutrients but did not change measures of plasma antioxidant capacity or vascular risk markers.
In healthy middle-aged adults, 7-week supplementation with fruit/vegetable concentrates raised blood levels of several antioxidants including vitamin C.
Supplementation with a fruit-and-vegetable concentrate increased plasma vitamin C and folate and modestly lowered homocysteine in men.
Isoflavone supplementation reduced homocysteine and some resting oxidative markers but did not change plasma vitamin C or prevent exercise-induced oxidative stress.
In CAD patients, folic acid supplementation markedly raised plasma folate and produced a modest homocysteine fall and a significant improvement in flow-mediated dilation versus placebo; adding antioxidants did not produce significant additional benefit.
One year of high-dose vitamin C (1,000 mg) plus vitamin E reduced oxidative stress markers and attenuated hip bone loss in elderly participants.
One year of high-dose vitamin C (1,000 mg) plus vitamin E reduced oxidative stress markers and attenuated hip bone loss in elderly participants.
One year of high-dose vitamin C (1,000 mg) plus vitamin E reduced oxidative stress markers and attenuated hip bone loss in elderly participants.
Antioxidant prophylaxis (vitamin C + E) reduced free‑radical signals during hypoxia/exercise but increased thrombin generation at rest.
Antioxidant prophylaxis (vitamin C + E) reduced free‑radical signals during hypoxia/exercise but increased thrombin generation at rest.
Supplementation with n‑3 PUFAs plus vitamins C (1 g/day) and E reduced post‑operative atrial fibrillation and increased cardiac antioxidant enzyme activity.
Daily 500 mg vitamin C for 8 years did not affect risk of visually significant age‑related macular degeneration.
Children with β-thalassemia and low vitamins received combined vitamin therapy for 12 months and showed improved antioxidant markers and reduced liver iron.
Children with β-thalassemia and low vitamins received combined vitamin therapy for 12 months and showed improved antioxidant markers and reduced liver iron.
In children with moderate–severe asthma, daily vitamins C+E prevented ozone-associated decreases in lung function.
In children with moderate–severe asthma, daily vitamins C+E prevented ozone-associated decreases in lung function.
In children with moderate–severe asthma, daily vitamins C+E prevented ozone-associated decreases in lung function.
2-L PEG with ascorbic acid and sodium picosulfate/magnesium citrate had similar overall cleansing; the SP/MC regimen had better tolerability and fewer adverse events.
Compared colonoscopy preparations; the low-volume PEG with ascorbic acid (PEGA) had similar cleansing efficacy to PEG when regimens matched and was better tolerated than PEG.
Perioperative IV vitamin C did not reduce postoperative AKI or improve eGFR after on-pump cardiac surgery; MDA (oxidative stress marker) was not reduced and was higher on POD1 in a subgroup.
Perioperative IV vitamin C did not reduce postoperative AKI or improve eGFR after on-pump cardiac surgery; MDA (oxidative stress marker) was not reduced and was higher on POD1 in a subgroup.
In healthy volunteers, inhalation of NO2 transiently lowered ascorbic acid (vitamin C) in bronchial and bronchoalveolar lavage at 1.5 h, returning to baseline by 6 h.
In healthy volunteers, inhalation of NO2 transiently lowered ascorbic acid (vitamin C) in bronchial and bronchoalveolar lavage at 1.5 h, returning to baseline by 6 h.
In healthy volunteers, inhalation of NO2 transiently lowered ascorbic acid (vitamin C) in bronchial and bronchoalveolar lavage at 1.5 h, returning to baseline by 6 h.
Combined supplementation with alpha-tocopherol and ascorbic acid attenuated the ribavirin-associated decrease in erythrocyte EPA but did not prevent ribavirin-induced anemia.
Combined supplementation with alpha-tocopherol and ascorbic acid attenuated the ribavirin-associated decrease in erythrocyte EPA but did not prevent ribavirin-induced anemia.
In this multicenter randomized trial of ischemic stroke patients, ascorbic acid (given alone) produced no significant morphologic regression of cerebral ischemia or clear clinical benefit, whereas cytoflavin regimens showed lesion volume regression and better outcomes in more severe patients.
In this multicenter randomized trial of ischemic stroke patients, ascorbic acid (given alone) produced no significant morphologic regression of cerebral ischemia or clear clinical benefit, whereas cytoflavin regimens showed lesion volume regression and better outcomes in more severe patients.
In this multicenter randomized trial of ischemic stroke patients, ascorbic acid (given alone) produced no significant morphologic regression of cerebral ischemia or clear clinical benefit, whereas cytoflavin regimens showed lesion volume regression and better outcomes in more severe patients.
Low-volume PEG with ascorbic acid achieved comparable bowel cleansing to 4 L PEG (90.6% vs 96% success, difference not statistically significant); tolerability similar.
In patients undergoing colonoscopy, 2L-PEG/ascorbic acid and an oral sulfate solution had similar successful bowel cleansing rates; tolerability and adverse events were comparable.
Low-volume PEG with ascorbic acid achieved comparable bowel cleansing to 4 L PEG (90.6% vs 96% success, difference not statistically significant); tolerability similar.
Low-volume PEG with ascorbic acid achieved comparable bowel cleansing to 4 L PEG (90.6% vs 96% success, difference not statistically significant); tolerability similar.
Men with higher vitamin C intake (>100 mg/day) had lower rates of esophageal cancer.
Men with higher vitamin C intake (>100 mg/day) had lower rates of esophageal cancer.
Daily antioxidant mixture including 750 mg vitamin C produced a small slowing of cataract progression over 3 years, mainly in the US cohort.
Oral vitamin C after cardioversion reduced early AF recurrence and lowered some inflammation markers.
Oral vitamin C after cardioversion reduced early AF recurrence and lowered some inflammation markers.
IV ascorbic acid improved haematocrit and iron availability and reduced erythropoietin dose in iron‑overloaded hemodialysis patients.
IV ascorbic acid improved haematocrit and iron availability and reduced erythropoietin dose in iron‑overloaded hemodialysis patients.
Multivitamins including vitamin C did not reduce restenosis after coronary angioplasty.
Multivitamins including vitamin C did not reduce restenosis after coronary angioplasty.
IV vitamin C (with vitamin E) prevented the halothane-induced drop in the acute hypoxic ventilatory response in healthy men.
Antioxidant vitamins (A, C, E) markedly reduced recurrence of colorectal polyps compared with no treatment.
A single IV infusion of multivitamin/mineral formulas moved patients' red blood cell ATP/ADP ratios toward the mean, an effect not seen in controls.
In elderly patients with chronic heart failure, long-term high-dose multiple micronutrient supplementation (including vitamin D) improved left ventricular volumes, increased LVEF and improved quality-of-life versus placebo.
Daily moderate antioxidant supplementation (including 272 mg vitamin C) raised plasma ascorbate but did not change measured markers of lipid or protein oxidative damage in healthy men.
In a randomized phase 3 trial, low-volume PEG with high-dose ascorbate (TJP-008) produced noninferior or superior bowel cleansing compared with 2 L PEG with ascorbate.
In a randomized phase 3 trial, low-volume PEG with high-dose ascorbate (TJP-008) produced noninferior or superior bowel cleansing compared with 2 L PEG with ascorbate.
Prophylactic 2,000 mg IV ascorbic acid given before plexus anesthesia with prilocaine did not reduce methemoglobin concentrations in patients.
Ascorbic acid (600 mg/day) did not significantly prevent interferon-associated retinopathy compared with no ascorbic acid.
Ascorbic acid (600 mg/day) did not significantly prevent interferon-associated retinopathy compared with no ascorbic acid.
Ascorbic acid (600 mg/day) did not significantly prevent interferon-associated retinopathy compared with no ascorbic acid.
Providing 350 g/day vegetables and using water-free (multi-ply) cookware increased blood vitamin C and reduced oxidized LDL and LDL cholesterol over 2 weeks compared with ordinary cooking or usual diet.
Giving vitamins including vitamin C with meals prevented post-meal rises in inflammatory and adhesion markers in healthy and type 2 diabetic people.
Giving vitamins including vitamin C with meals prevented post-meal rises in inflammatory and adhesion markers in healthy and type 2 diabetic people.
Giving vitamins including vitamin C with meals prevented post-meal rises in inflammatory and adhesion markers in healthy and type 2 diabetic people.
Taking 2 g/day vitamin C increased urinary oxalate and calcium-oxalate saturation but did not change urine pH.
Taking 2 g/day vitamin C increased urinary oxalate and calcium-oxalate saturation but did not change urine pH.
Taking 2 g/day vitamin C increased urinary oxalate and calcium-oxalate saturation but did not change urine pH.
PEG with ascorbic acid tasted worse and was more distressing but achieved similar completion rates and bowel-cleansing quality compared with SPS-Mg.
PEG with ascorbic acid tasted worse and was more distressing but achieved similar completion rates and bowel-cleansing quality compared with SPS-Mg.
PEG with ascorbic acid tasted worse and was more distressing but achieved similar completion rates and bowel-cleansing quality compared with SPS-Mg.
PEG with ascorbic acid and sodium phosphate tablets achieved similar bowel-cleaning quality and detection rates, but patient satisfaction and compliance favored sodium phosphate tablets.
PEG with ascorbic acid and sodium phosphate tablets achieved similar bowel-cleaning quality and detection rates, but patient satisfaction and compliance favored sodium phosphate tablets.
Compared bowel preparations including polyethylene glycol with ascorbic acid and found similar optimal preparation intervals and overall efficacy; tolerability depended on product type.
Compared bowel preparations including polyethylene glycol with ascorbic acid and found similar optimal preparation intervals and overall efficacy; tolerability depended on product type.
In type 2 diabetic patients on metformin, adding 500 mg vitamin C daily for 12 months improved fasting glucose, HbA1c and albumin-to-creatinine ratio versus metformin alone.
Oral antioxidant combination including vitamin C (1,000 mg) improved endothelium-dependent vasodilation in type 1 but not type 2 diabetic patients after 6 months.
Oral antioxidant combination including vitamin C (1,000 mg) improved endothelium-dependent vasodilation in type 1 but not type 2 diabetic patients after 6 months.
In patients undergoing colonoscopy, 2L-PEG/ascorbic acid and an oral sulfate solution had similar successful bowel cleansing rates; tolerability and adverse events were comparable.
In patients undergoing colonoscopy, 2L-PEG/ascorbic acid and an oral sulfate solution had similar successful bowel cleansing rates; tolerability and adverse events were comparable.
Two-month randomized double-blind supplementation with multiple antioxidants (including ascorbic acid) reduced intrinsic and UV-induced lymphocyte apoptosis, especially in young and elderly adults.
Two-month randomized double-blind supplementation with multiple antioxidants (including ascorbic acid) reduced intrinsic and UV-induced lymphocyte apoptosis, especially in young and elderly adults.
Two-month randomized double-blind supplementation with multiple antioxidants (including ascorbic acid) reduced intrinsic and UV-induced lymphocyte apoptosis, especially in young and elderly adults.
Preprocedure intravenous 3 g vitamin C reduced the incidence of periprocedural myocardial injury in patients undergoing elective PCI.
Preprocedure intravenous 3 g vitamin C reduced the incidence of periprocedural myocardial injury in patients undergoing elective PCI.
Topical antioxidant cocktail (including vitamin C) applied with sunscreen reduced IRA-induced MMP-1 in human skin versus sunscreen alone.
In asthmatic children, daily supplementation with vitamins C and E prevented ozone-induced increases in nasal IL-6.
In asthmatic children, daily supplementation with vitamins C and E prevented ozone-induced increases in nasal IL-6.
In asthmatic children, daily supplementation with vitamins C and E prevented ozone-induced increases in nasal IL-6.
In people with type 2 diabetes, 4 months of 1 g/day ascorbic acid reduced post-meal and 24-hour glucose measures, lowered blood pressure, and reduced an oxidative stress marker.
In people with type 2 diabetes, 4 months of 1 g/day ascorbic acid reduced post-meal and 24-hour glucose measures, lowered blood pressure, and reduced an oxidative stress marker.
In people with type 2 diabetes, 4 months of 1 g/day ascorbic acid reduced post-meal and 24-hour glucose measures, lowered blood pressure, and reduced an oxidative stress marker.
In people with type 2 diabetes, 4 months of 1 g/day ascorbic acid reduced post-meal and 24-hour glucose measures, lowered blood pressure, and reduced an oxidative stress marker.
In people with type 2 diabetes, 4 months of 1 g/day ascorbic acid reduced post-meal and 24-hour glucose measures, lowered blood pressure, and reduced an oxidative stress marker.
Acute and 30-day ascorbic acid increased plasma vitamin C and reduced oxidized LDL acutely, but did not change VO2max or maximal cardiac output in young or older adults.
Acute and 30-day ascorbic acid increased plasma vitamin C and reduced oxidized LDL acutely, but did not change VO2max or maximal cardiac output in young or older adults.
Acute and 30-day ascorbic acid increased plasma vitamin C and reduced oxidized LDL acutely, but did not change VO2max or maximal cardiac output in young or older adults.
Randomized blind clinical study in preschool children testing water fortification with iron+ascorbic acid, ascorbic acid alone, or plain water over 3 months; hemoglobin rose in all groups, MCV improved with iron+ascorbic and with ascorbic alone, ferritin increased only with iron+ascorbic.
Genotype influences whether antioxidant and/or zinc supplements reduce progression to advanced AMD; different genotypes derive benefit from different supplement regimens.
Genotype influences whether antioxidant and/or zinc supplements reduce progression to advanced AMD; different genotypes derive benefit from different supplement regimens.
Re-infusive convective dialysis techniques (HFR and HFR-S) reduced intradialytic loss of vitamin C (~15% less loss vs ol-HDF) but did not produce a significant long-term increase in plasma vitamin C; overall oxidative markers improved.
Re-infusive convective dialysis techniques (HFR and HFR-S) reduced intradialytic loss of vitamin C (~15% less loss vs ol-HDF) but did not produce a significant long-term increase in plasma vitamin C; overall oxidative markers improved.
Re-infusive convective dialysis techniques (HFR and HFR-S) reduced intradialytic loss of vitamin C (~15% less loss vs ol-HDF) but did not produce a significant long-term increase in plasma vitamin C; overall oxidative markers improved.
Phlebotomy to reduce iron stores did not change CYP2E1 activity but was associated with lower LDL and vitamin E and a small but significant increase in plasma vitamin C.
Phlebotomy to reduce iron stores did not change CYP2E1 activity but was associated with lower LDL and vitamin E and a small but significant increase in plasma vitamin C.
In type 2 diabetic patients, combined mineral+vitamin supplementation (including zinc) improved urinary albumin and several metabolic and lipid markers, whereas mineral alone did not show clear benefit.
In type 2 diabetic patients, combined mineral+vitamin supplementation (including zinc) improved urinary albumin and several metabolic and lipid markers, whereas mineral alone did not show clear benefit.
In type 2 diabetic patients, combined mineral+vitamin supplementation (including zinc) improved urinary albumin and several metabolic and lipid markers, whereas mineral alone did not show clear benefit.
In this large randomized trial of combined atorvastatin plus vitamin C and E vs placebo, treatment did not alter progression of coronary calcification; possible non-significant reduction in ASCVD events was observed.
In this large randomized trial of combined atorvastatin plus vitamin C and E vs placebo, treatment did not alter progression of coronary calcification; possible non-significant reduction in ASCVD events was observed.
In patients with fatty liver disease, 6 months of vitamin E (600 IU) plus vitamin C (500 mg) improved liver enzymes similarly to ursodeoxycholic acid; ALT normalized in ~63% vs 55% respectively.
In patients with fatty liver disease, 6 months of vitamin E (600 IU) plus vitamin C (500 mg) improved liver enzymes similarly to ursodeoxycholic acid; ALT normalized in ~63% vs 55% respectively.
In patients with fatty liver disease, 6 months of vitamin E (600 IU) plus vitamin C (500 mg) improved liver enzymes similarly to ursodeoxycholic acid; ALT normalized in ~63% vs 55% respectively.
In middle-aged men with mildly high homocysteine, 8 weeks of B vitamins and/or antioxidants (including 150 mg ascorbic acid) did not change ADMA or CRP versus placebo.
In middle-aged men with mildly high homocysteine, 8 weeks of B vitamins and/or antioxidants (including 150 mg ascorbic acid) did not change ADMA or CRP versus placebo.
Critically ill patients receiving enteral formula enriched with vitamins A, C, and E showed increased plasma antioxidant vitamins and improved LDL resistance to oxidation, with no change in clinical outcomes.
Daily supplementation (vitamin C + E + zinc + selenium) for 17 weeks improved quadriceps maximal voluntary contraction and endurance and altered antioxidant markers, but did not improve 2-minute walk distance.
Daily supplementation (vitamin C + E + zinc + selenium) for 17 weeks improved quadriceps maximal voluntary contraction and endurance and altered antioxidant markers, but did not improve 2-minute walk distance.
Adding vitamins C+E to intensive statin therapy did not provide additional benefit on measures of myocardial ischemia.
Adding vitamins C+E to intensive statin therapy did not provide additional benefit on measures of myocardial ischemia.
Adding vitamins C+E to intensive statin therapy did not provide additional benefit on measures of myocardial ischemia.
An acute antioxidant cocktail including vitamin C improved vascular function measures in COPD patients compared with placebo.
A perioperative antioxidant-containing drink raised plasma vitamin C and total antioxidant capacity shortly after surgery but did not reduce markers of systemic inflammation.
A perioperative antioxidant-containing drink raised plasma vitamin C and total antioxidant capacity shortly after surgery but did not reduce markers of systemic inflammation.
Five-year randomized trial found that supplements including vitamin C, vitamin E and beta carotene did not slow cataract progression versus placebo.
Five-year randomized trial found that supplements including vitamin C, vitamin E and beta carotene did not slow cataract progression versus placebo.
Five-year randomized trial found that supplements including vitamin C, vitamin E and beta carotene did not slow cataract progression versus placebo.
Intravenous ascorbic acid did not attenuate etomidate-induced suppression of adrenal steroid production in this small clinical study.
In patients with prior nonmelanoma skin cancer, 60 days of antioxidant supplementation including zinc produced modest reductions in oxidative stress biomarkers (notably 15-F2t-isoprostane) but differences versus placebo were not statistically significant.
In patients with prior nonmelanoma skin cancer, 60 days of antioxidant supplementation including zinc produced modest reductions in oxidative stress biomarkers (notably 15-F2t-isoprostane) but differences versus placebo were not statistically significant.
Antioxidant vitamins including vitamin C (500 mg twice daily) did not improve flow-mediated dilation or nitroglycerin-induced dilation in postmenopausal women with coronary artery disease.
An enteral diet enriched with EPA, GLA and vitamins A, C and E reduced the occurrence of new pressure ulcers but did not affect healing of existing ulcers in critically ill patients.
An enteral diet enriched with EPA, GLA and vitamins A, C and E reduced the occurrence of new pressure ulcers but did not affect healing of existing ulcers in critically ill patients.
Sequential intracoronary ascorbic acid infusions did not improve acetylcholine-induced coronary vasodilation or nitroglycerin responses in patients with coronary atherosclerosis.
Sequential intracoronary ascorbic acid infusions did not improve acetylcholine-induced coronary vasodilation or nitroglycerin responses in patients with coronary atherosclerosis.
Long-term low-dose antioxidant/multi-mineral supplementation (including 20 mg zinc) reduced total cancer incidence and all-cause mortality in men but not in women over ~7.5 years.
Long-term low-dose antioxidant/multi-mineral supplementation (including 20 mg zinc) reduced total cancer incidence and all-cause mortality in men but not in women over ~7.5 years.
Analysis of factors linked to blood vitamin E levels in postmenopausal women; supplemental vitamin C was associated with higher alpha- and lower gamma-tocopherol.
Double-blind placebo-controlled human study of acute methionine-induced homocysteinemia testing high-dose antioxidant vitamins (2 g vitamin C + 800 IU vitamin E) vs placebo; vitamins reduced lipid peroxidation in hypertensives but did not prevent endothelial dysfunction or ET-1 elevation.
Double-blind placebo-controlled human study of acute methionine-induced homocysteinemia testing high-dose antioxidant vitamins (2 g vitamin C + 800 IU vitamin E) vs placebo; vitamins reduced lipid peroxidation in hypertensives but did not prevent endothelial dysfunction or ET-1 elevation.
Double-blind placebo-controlled human study of acute methionine-induced homocysteinemia testing high-dose antioxidant vitamins (2 g vitamin C + 800 IU vitamin E) vs placebo; vitamins reduced lipid peroxidation in hypertensives but did not prevent endothelial dysfunction or ET-1 elevation.
Combined cohorts (one RCT supplementation subset) of asthmatic children examined longitudinally; low dietary vitamin C intake (≤105 mg/day) was associated with larger ozone-induced decrements in small-airway function (FEF25-75), especially in persistent asthmatics and genetically susceptible children.
Combined cohorts (one RCT supplementation subset) of asthmatic children examined longitudinally; low dietary vitamin C intake (≤105 mg/day) was associated with larger ozone-induced decrements in small-airway function (FEF25-75), especially in persistent asthmatics and genetically susceptible children.
Combined cohorts (one RCT supplementation subset) of asthmatic children examined longitudinally; low dietary vitamin C intake (≤105 mg/day) was associated with larger ozone-induced decrements in small-airway function (FEF25-75), especially in persistent asthmatics and genetically susceptible children.
Randomized placebo-controlled 2×2 factorial trial in healthy adults testing micronutrient mix (including vitamin C) and bovine colostrum over 10 weeks; micronutrient supplementation raised plasma vitamin C and other micronutrients and enhanced delayed-type hypersensitivity (DTH) responses, especially in older subjects; most other immune parameters unchanged.
Randomized placebo-controlled 2×2 factorial trial in healthy adults testing micronutrient mix (including vitamin C) and bovine colostrum over 10 weeks; micronutrient supplementation raised plasma vitamin C and other micronutrients and enhanced delayed-type hypersensitivity (DTH) responses, especially in older subjects; most other immune parameters unchanged.
Two weeks of a phenolic-rich dessert in institutionalised elderly produced no significant changes in antioxidant capacity, antioxidant vitamins (including vitamin C), LDL peroxidation or DNA damage.
In surgical patients on TPN, plasma vitamin C and other non-supplemented antioxidants fell during TPN despite alpha-tocopherol supplementation normalizing tocopherol levels in one group.
Two weeks of a phenolic-rich dessert in institutionalised elderly produced no significant changes in antioxidant capacity, antioxidant vitamins (including vitamin C), LDL peroxidation or DNA damage.
Two weeks of a phenolic-rich dessert in institutionalised elderly produced no significant changes in antioxidant capacity, antioxidant vitamins (including vitamin C), LDL peroxidation or DNA damage.
Controlled diet crossover: 30 g alcohol/day decreased alpha‑tocopherol modestly and marginally increased isoprostanes; vitamin C and selenium were not significantly changed.
Controlled diet crossover: 30 g alcohol/day decreased alpha‑tocopherol modestly and marginally increased isoprostanes; vitamin C and selenium were not significantly changed.
Controlled diet crossover: 30 g alcohol/day decreased alpha‑tocopherol modestly and marginally increased isoprostanes; vitamin C and selenium were not significantly changed.
Combined succimer with calcium and ascorbic acid produced greater reductions in blood lead levels and higher rates of achieving BLL <10 μg/dL compared with nutritional intervention alone.
Combined succimer with calcium and ascorbic acid produced greater reductions in blood lead levels and higher rates of achieving BLL <10 μg/dL compared with nutritional intervention alone.
Combined succimer with calcium and ascorbic acid produced greater reductions in blood lead levels and higher rates of achieving BLL <10 μg/dL compared with nutritional intervention alone.
In short-term supplementation in well-controlled type 2 diabetes, vitamin C (500 mg/day) did not meaningfully change LDL oxidation susceptibility, CRP, or adhesion molecules.
In cancer patients receiving cisplatin-based chemotherapy, a beverage containing antioxidants including vitamin C did not prevent chemotherapy-induced chromosomal damage.
In cancer patients receiving cisplatin-based chemotherapy, a beverage containing antioxidants including vitamin C did not prevent chemotherapy-induced chromosomal damage.
In cancer patients receiving cisplatin-based chemotherapy, a beverage containing antioxidants including vitamin C did not prevent chemotherapy-induced chromosomal damage.
In inactive ulcerative colitis patients, bowel prep containing ascorbic acid (vitamin C) had similar cleansing efficacy and symptom flare risk but higher willingness to repeat.
In inactive ulcerative colitis patients, bowel prep containing ascorbic acid (vitamin C) had similar cleansing efficacy and symptom flare risk but higher willingness to repeat.
In inactive ulcerative colitis patients, bowel prep containing ascorbic acid (vitamin C) had similar cleansing efficacy and symptom flare risk but higher willingness to repeat.
Adding sodium ascorbate (vitamin C) to bowel purge did not improve capsule endoscopy diagnostic yield or small-bowel visualization and was less well tolerated than clear fluids alone.
Adding sodium ascorbate (vitamin C) to bowel purge did not improve capsule endoscopy diagnostic yield or small-bowel visualization and was less well tolerated than clear fluids alone.
Adding sodium ascorbate (vitamin C) to bowel purge did not improve capsule endoscopy diagnostic yield or small-bowel visualization and was less well tolerated than clear fluids alone.
In hemodialysis patients with iron overload, intravenous ascorbic acid did not increase iron mobilization but improved response to erythropoietin.
In hemodialysis patients with iron overload, intravenous ascorbic acid did not increase iron mobilization but improved response to erythropoietin.
In hemodialysis patients with iron overload, intravenous ascorbic acid did not increase iron mobilization but improved response to erythropoietin.
Giving vitamin C to brain-dead donors reduced IL-6 gene expression and improved early liver enzyme levels in transplant recipients.
Giving vitamin C to brain-dead donors reduced IL-6 gene expression and improved early liver enzyme levels in transplant recipients.
Giving vitamin C to brain-dead donors reduced IL-6 gene expression and improved early liver enzyme levels in transplant recipients.
An ascorbic acid–enriched PEG solution prepared the bowel as well as standard PEG with a lower total drinking volume.
An ascorbic acid–enriched PEG solution prepared the bowel as well as standard PEG with a lower total drinking volume.
Vitamin C 515 mg/day lowered plasma CRP by about 24% versus control over 2 months.
In short-term supplementation in well-controlled type 2 diabetes, vitamin C (500 mg/day) did not meaningfully change LDL oxidation susceptibility, CRP, or adhesion molecules.
Intravenous vitamin C did not reduce rates of colistin-associated nephrotoxicity in this small randomized trial.
Intravenous vitamin C did not reduce rates of colistin-associated nephrotoxicity in this small randomized trial.
Intravenous vitamin C did not reduce rates of colistin-associated nephrotoxicity in this small randomized trial.
In a 6-month randomized trial subgroup, multivitamin use was associated with lower CRP levels compared with placebo.
Adding vitamin C to standard antibiotic and topical therapy reduced pain with intercourse and vaginal discharge in women treated for chlamydial cervicitis.
Adding vitamin C to standard antibiotic and topical therapy reduced pain with intercourse and vaginal discharge in women treated for chlamydial cervicitis.
Adding vitamin C to standard antibiotic and topical therapy reduced pain with intercourse and vaginal discharge in women treated for chlamydial cervicitis.
Oral antioxidant pool given before and during NB-UVB phototherapy improved repigmentation and reduced oxidative stress in patients with nonsegmental vitiligo.
Oral antioxidant pool given before and during NB-UVB phototherapy improved repigmentation and reduced oxidative stress in patients with nonsegmental vitiligo.
Oral antioxidant pool given before and during NB-UVB phototherapy improved repigmentation and reduced oxidative stress in patients with nonsegmental vitiligo.
In CAD patients on simvastatin+niacin, adding antioxidant vitamins (including vitamin C) blunted the favorable increases in HDL metrics observed with lipid therapy alone.
Drinking 500 mL/day orange juice while doing aerobic training for 3 months was associated with better cholesterol and less muscle fatigue.
Adding vitamin C to simvastatin did not provide lipid-profile benefits beyond simvastatin alone in patients with low HDL-C.
Adding ascorbic acid (vitamin C) together with phytase and NaFeEDTA markedly increased iron absorption from a maize meal.
Adding ascorbic acid (vitamin C) together with phytase and NaFeEDTA markedly increased iron absorption from a maize meal.
Adding ascorbic acid (vitamin C) together with phytase and NaFeEDTA markedly increased iron absorption from a maize meal.
A 2-year RCT of combined antioxidants including vitamin C showed no improvement or stabilization of cognitive decline in individuals with Down syndrome and dementia.
In 48 myeloma patients undergoing stem-cell transplant, adding arsenic trioxide plus ascorbic acid to high-dose melphalan was safe and produced responses but showed no difference among arms.
In 48 myeloma patients undergoing stem-cell transplant, adding arsenic trioxide plus ascorbic acid to high-dose melphalan was safe and produced responses but showed no difference among arms.
In 48 myeloma patients undergoing stem-cell transplant, adding arsenic trioxide plus ascorbic acid to high-dose melphalan was safe and produced responses but showed no difference among arms.
In 501 critically ill sepsis patients, IV vitamin C plus thiamine and hydrocortisone did not increase ventilator- and vasopressor-free days or reduce 30-day mortality compared with placebo.
In adolescents with poorly controlled type 1 diabetes, improved glycemic control and 3–6 months of antioxidant supplementation (including vitamin C) did not restore erythrocyte glutathione or reduce markers of oxidative stress.
Perioperative multi-antioxidant treatment (including vitamin C) did not reduce albuminuria but was associated with higher creatinine clearance on day 2.
Perioperative multi-antioxidant treatment (including vitamin C) did not reduce albuminuria but was associated with higher creatinine clearance on day 2.
Daily guava juice (≈200 mg ascorbic acid) given with a meal modestly increased hemoglobin and had a smaller, non-significant increase in ferritin in mildly anemic children.
Vitamin C quickly and sustainably improved blood-vessel dilation in patients with coronary artery disease.
A combination of vitamins E and C reduced chronic pelvic pain and lowered inflammatory markers in women with endometriosis.
A combination of vitamins E and C reduced chronic pelvic pain and lowered inflammatory markers in women with endometriosis.
A combination of vitamins E and C reduced chronic pelvic pain and lowered inflammatory markers in women with endometriosis.
Children given multiple micronutrients including vitamin C had higher plasma antioxidant levels and less oxidized DNA damage in lymphocytes.
Adding ascorbic acid to a reduced-volume bowel prep gave the same cleansing success with better tolerability and fewer side effects.
Adding ascorbic acid to a reduced-volume bowel prep gave the same cleansing success with better tolerability and fewer side effects.
Adding ascorbic acid to a reduced-volume bowel prep gave the same cleansing success with better tolerability and fewer side effects.
Vitamin A+C given for 1 month produced mixed effects on oxidative-stress markers: some markers improved in HIV-only patients but worsened or did not improve in HIV-TB co-infected patients.
Patients with chronic bacterial prostatitis had lower plasma vitamin C and antioxidant enzymes and higher oxidative-damage markers than healthy controls.
Large RCT found no reduction in overall spontaneous preterm birth with vitamins C+E, though births from preterm PROM before 32 weeks were less frequent with vitamins.
Large RCT found no reduction in overall spontaneous preterm birth with vitamins C+E, though births from preterm PROM before 32 weeks were less frequent with vitamins.
In ICU patients with sepsis on vasopressors, IV vitamin C increased the risk of death or persistent organ dysfunction at 28 days compared with placebo.
A cream containing hydroquinone, glycolic acid, vitamins C and E, and sunscreen reduced facial melasma pigmentation vs sunscreen alone over 12 weeks; irritation was more common but transient.
A cream containing hydroquinone, glycolic acid, vitamins C and E, and sunscreen reduced facial melasma pigmentation vs sunscreen alone over 12 weeks; irritation was more common but transient.
In this large prospective cohort of male smokers, dietary vitamin C intake was not associated with incidence of type 2 diabetes after multivariate adjustment.
Large RCT in adults on HAART compared high- vs standard-dose multivitamins (including vitamin C); no benefit for disease progression or death but increased liver enzyme elevations with high-dose.
Large RCT in adults on HAART compared high- vs standard-dose multivitamins (including vitamin C); no benefit for disease progression or death but increased liver enzyme elevations with high-dose.
Large RCT in adults on HAART compared high- vs standard-dose multivitamins (including vitamin C); no benefit for disease progression or death but increased liver enzyme elevations with high-dose.
Phase 3 RCT found adding high‑dose IV vitamin C to first-line chemotherapy did not improve progression-free survival overall, but RAS‑mutant patients showed improved PFS in prespecified subgroup analysis.
Phase 3 RCT found adding high‑dose IV vitamin C to first-line chemotherapy did not improve progression-free survival overall, but RAS‑mutant patients showed improved PFS in prespecified subgroup analysis.
Phase 3 RCT found adding high‑dose IV vitamin C to first-line chemotherapy did not improve progression-free survival overall, but RAS‑mutant patients showed improved PFS in prespecified subgroup analysis.
In a crossover stable‑isotope study of 30 Malawian infants, ascorbic acid–fortified cereals supported measurable iron absorption, with fractional iron absorption varying by cereal formulation.
In a crossover stable‑isotope study of 30 Malawian infants, ascorbic acid–fortified cereals supported measurable iron absorption, with fractional iron absorption varying by cereal formulation.
In a crossover stable‑isotope study of 30 Malawian infants, ascorbic acid–fortified cereals supported measurable iron absorption, with fractional iron absorption varying by cereal formulation.
In hypertensive men, 8 weeks of vitamins C (1 g/day) + E increased erythrocyte (Na,K)-ATPase activity, improved oxidative stress markers and reduced blood pressure versus placebo.
High‑dose zinc gluconate (50 mg nightly) did not significantly shorten time to 50% symptom reduction or other clinical endpoints in outpatients with COVID-19 compared with usual care.
High‑dose zinc gluconate (50 mg nightly) did not significantly shorten time to 50% symptom reduction or other clinical endpoints in outpatients with COVID-19 compared with usual care.
High‑dose zinc gluconate (50 mg nightly) did not significantly shorten time to 50% symptom reduction or other clinical endpoints in outpatients with COVID-19 compared with usual care.
Preconditioning antioxidant supplementation (including 450 mg ascorbic acid) was associated with higher antioxidant levels and reduced markers of lipid peroxidation compared with no supplementation.
Preconditioning antioxidant supplementation (including 450 mg ascorbic acid) was associated with higher antioxidant levels and reduced markers of lipid peroxidation compared with no supplementation.
Preconditioning antioxidant supplementation (including 450 mg ascorbic acid) was associated with higher antioxidant levels and reduced markers of lipid peroxidation compared with no supplementation.
A 12-week water-soluble vitamin supplement improved some vitamin biomarkers, increased weight, and lowered homocysteine in elderly female residents; plasma vitamin C rose in both groups.
Adults with metabolic syndrome counseled on DASH diet plus low-sodium vegetable juice (a source of vitamin C) increased vitamin C intake and experienced modestly greater weight loss; oxidative stress markers did not change.
Addition of L-ascorbic acid (with chitosan) for 8 weeks accentuated weight and BMI reduction compared with chitosan alone or placebo; BMI decrease was greater with ascorbic acid plus chitosan.
A 6‑month lifestyle intervention led to weight loss and increased physical activity; measured vitamin C intake (marker of fruit/vegetable intake) showed no difference between groups.
Addition of L-ascorbic acid (with chitosan) for 8 weeks accentuated weight and BMI reduction compared with chitosan alone or placebo; BMI decrease was greater with ascorbic acid plus chitosan.
Combined antioxidant therapy including vitamin C (1,000 mg/day) given after suspected MI was associated with smaller mean infarct size and reduced oxidative markers and cardiac events versus placebo, but vitamins were given as a combination so effects cannot be attributed to vitamin C alone.
Combined antioxidant therapy including vitamin C (1,000 mg/day) given after suspected MI was associated with smaller mean infarct size and reduced oxidative markers and cardiac events versus placebo, but vitamins were given as a combination so effects cannot be attributed to vitamin C alone.
Drinking 500 mL/day orange juice while doing aerobic training for 3 months was associated with better cholesterol and less muscle fatigue.
In short-term supplementation in well-controlled type 2 diabetes, vitamin C (500 mg/day) did not meaningfully change LDL oxidation susceptibility, CRP, or adhesion molecules.
Low-dose vitamin supplementation (including 120 mg vitamin C) for 2 years increased nutrient levels and improved a red blood cell antioxidant resistance assay in elderly participants.
Adding ascorbic acid (with low-dose NAC) did not reduce contrast-induced kidney injury compared with hydration alone; high-dose NAC plus hydration was superior.
Short-term perioperative ascorbic acid did not reduce the postoperative rise in inflammatory markers after cardiothoracic surgery.
A feeding trial comparing diets raised vitamin C intake and produced substantially greater systolic blood pressure reduction, but the study assessed a whole-diet intervention (not isolated vitamin C).
Fifteen days of combined antioxidant therapy (NAC, vitamin E, vitamin C 250 mg/d) reduced postprandial oxidative stress and improved endothelial function markers across diabetes, IGT, and control groups.
Fifteen days of combined antioxidant therapy (NAC, vitamin E, vitamin C 250 mg/d) reduced postprandial oxidative stress and improved endothelial function markers across diabetes, IGT, and control groups.
Fifteen days of combined antioxidant therapy (NAC, vitamin E, vitamin C 250 mg/d) reduced postprandial oxidative stress and improved endothelial function markers across diabetes, IGT, and control groups.
Low-volume PEG plus ascorbic acid provided bowel cleansing efficacy and tolerability comparable to high-volume PEG plus simethicon for colonoscopy prep.
Low-volume PEG plus ascorbic acid provided bowel cleansing efficacy and tolerability comparable to high-volume PEG plus simethicon for colonoscopy prep.
Ferrous ascorbate raised hemoglobin and cured more children of anemia than colloidal iron over 12 weeks.
Individualized nutrition support in malnourished hospital patients improved energy/protein intake, maintained weight, raised vitamin C levels, and reduced complications and readmissions.
Individualized nutrition support in malnourished hospital patients improved energy/protein intake, maintained weight, raised vitamin C levels, and reduced complications and readmissions.
The effect of AREDS vitamins (including vitamin C) on progression to advanced AMD varied by CFH and ARMS2 genotype, with antioxidants beneficial in one genotype group but zinc harmful in others.
The effect of AREDS vitamins (including vitamin C) on progression to advanced AMD varied by CFH and ARMS2 genotype, with antioxidants beneficial in one genotype group but zinc harmful in others.
1-L PEG plus ascorbate was noninferior to 4-L PEG for colon cleansing, had higher patient compliance, and similar safety.
1-L PEG plus ascorbate was noninferior to 4-L PEG for colon cleansing, had higher patient compliance, and similar safety.
High-dose vitamin C (2 g/day for 4 weeks) improved forearm reactive hyperemia and reduced plasma vWF, tPA, and factor V in patients with type 2 diabetes and CAD.
High-dose vitamin C (2 g/day for 4 weeks) improved forearm reactive hyperemia and reduced plasma vWF, tPA, and factor V in patients with type 2 diabetes and CAD.
In healthy subjects and people with type 1 diabetes, hyperglycemic recovery from hypoglycemia worsened thrombosis and oxidative markers; intravenous vitamin C partially reversed these worsening effects.
High-dose vitamin C (2 g/day for 4 weeks) improved forearm reactive hyperemia and reduced plasma vWF, tPA, and factor V in patients with type 2 diabetes and CAD.
Two formulations of encapsulated juice powder reduced several inflammatory chemokines and increased antioxidant enzyme activity and micronutrient levels (including vitamin C) versus placebo after 60 days.
Two formulations of encapsulated juice powder reduced several inflammatory chemokines and increased antioxidant enzyme activity and micronutrient levels (including vitamin C) versus placebo after 60 days.
Two formulations of encapsulated juice powder reduced several inflammatory chemokines and increased antioxidant enzyme activity and micronutrient levels (including vitamin C) versus placebo after 60 days.
Early antioxidant supplementation including ascorbic acid in critically ill surgical patients reduced multiple organ failure (RR 0.43) and shortened mechanical ventilation and ICU stay; pulmonary morbidity reduction was not statistically significant.
Early antioxidant supplementation including ascorbic acid in critically ill surgical patients reduced multiple organ failure (RR 0.43) and shortened mechanical ventilation and ICU stay; pulmonary morbidity reduction was not statistically significant.
Early antioxidant supplementation including ascorbic acid in critically ill surgical patients reduced multiple organ failure (RR 0.43) and shortened mechanical ventilation and ICU stay; pulmonary morbidity reduction was not statistically significant.
Pilot randomized placebo-controlled trial of IV micronutrient therapy (includes vitamin C) in fibromyalgia showed within-group clinical improvements but no statistically significant differences versus placebo.
Pilot randomized placebo-controlled trial of IV micronutrient therapy (includes vitamin C) in fibromyalgia showed within-group clinical improvements but no statistically significant differences versus placebo.
Pilot randomized placebo-controlled trial of IV micronutrient therapy (includes vitamin C) in fibromyalgia showed within-group clinical improvements but no statistically significant differences versus placebo.
Oral procyanidin combined with vitamins A, C, and E reduced facial pigmentation in women with epidermal melasma over 8 weeks.
Oral procyanidin combined with vitamins A, C, and E reduced facial pigmentation in women with epidermal melasma over 8 weeks.
Oral procyanidin combined with vitamins A, C, and E reduced facial pigmentation in women with epidermal melasma over 8 weeks.
Patients with acute pancreatitis or colorectal cancer had lower serum vitamin C than healthy controls; antioxidant depletion accompanied increased oxidative stress markers.
In this large trial, folic acid/B vitamins did not alter diabetes risk; randomization to vitamin C in the parent factorial trial did not meaningfully change diabetes incidence.
A low-volume PEG preparation containing ascorbate (PEG-A) provided noninferior bowel cleansing compared with standard 4 L PEG in screening colonoscopy.
Iron-containing micronutrient supplements that included vitamin C improved hemoglobin and increased ferritin (iron stores); weekly 60 mg iron regimen was effective and better tolerated.
Sprinkles provided measurable absorbed zinc (dose‑dependent total absorbed) and did not affect iron absorption in young children.
Sprinkles provided measurable absorbed zinc (dose‑dependent total absorbed) and did not affect iron absorption in young children.
Sprinkles provided measurable absorbed zinc (dose‑dependent total absorbed) and did not affect iron absorption in young children.
In variegate porphyria patients, 6-month supplementation with vitamin E (50 mg) + vitamin C (150 mg) increased PPOX gene expression and raised antioxidant enzyme activities.
In variegate porphyria patients, 6-month supplementation with vitamin E (50 mg) + vitamin C (150 mg) increased PPOX gene expression and raised antioxidant enzyme activities.
Lifestyle intervention improved liver histology and lab markers in pediatric NAFLD; adding alpha-tocopherol + ascorbic acid did not provide additional benefit.
Lifestyle intervention improved liver histology and lab markers in pediatric NAFLD; adding alpha-tocopherol + ascorbic acid did not provide additional benefit.
Lifestyle intervention improved liver histology and lab markers in pediatric NAFLD; adding alpha-tocopherol + ascorbic acid did not provide additional benefit.
Eight-week randomized trial in 72 middle-aged subjects with cardiovascular risk factors: moderate berry consumption improved platelet function, raised HDL, and lowered systolic blood pressure in those with high baseline BP.
In healthy subjects and people with type 1 diabetes, hyperglycemic recovery from hypoglycemia worsened thrombosis and oxidative markers; intravenous vitamin C partially reversed these worsening effects.
In healthy subjects and people with type 1 diabetes, hyperglycemic recovery from hypoglycemia worsened thrombosis and oxidative markers; intravenous vitamin C partially reversed these worsening effects.
In a randomized trial of 30 adults, supplementation with glutathione precursors (with or without polydatin) increased endogenous GSH and raised endogenous vitamin C, E and A levels; polydatin‑containing formula also reduced urinary neopterin.
In a randomized trial of 30 adults, supplementation with glutathione precursors (with or without polydatin) increased endogenous GSH and raised endogenous vitamin C, E and A levels; polydatin‑containing formula also reduced urinary neopterin.
In a randomized trial of 30 adults, supplementation with glutathione precursors (with or without polydatin) increased endogenous GSH and raised endogenous vitamin C, E and A levels; polydatin‑containing formula also reduced urinary neopterin.
Young men took vitamin C (500 mg) together with different vitamin E forms; exercise normally raised muscle and serum HSP72 but this increase was fully prevented only when gamma-tocopherol was included, and lipid-peroxidation marker rise was reduced with alpha-tocopherol + vitamin C.
Young men took vitamin C (500 mg) together with different vitamin E forms; exercise normally raised muscle and serum HSP72 but this increase was fully prevented only when gamma-tocopherol was included, and lipid-peroxidation marker rise was reduced with alpha-tocopherol + vitamin C.
Young men took vitamin C (500 mg) together with different vitamin E forms; exercise normally raised muscle and serum HSP72 but this increase was fully prevented only when gamma-tocopherol was included, and lipid-peroxidation marker rise was reduced with alpha-tocopherol + vitamin C.
In young women, adding ascorbic acid (4:1 molar ratio to iron) to fortified cereal markedly increased iron absorption from ferric pyrophosphate and ferrous sulfate; food matrix and iron status strongly modified absorption.
In young women, adding ascorbic acid (4:1 molar ratio to iron) to fortified cereal markedly increased iron absorption from ferric pyrophosphate and ferrous sulfate; food matrix and iron status strongly modified absorption.
In young women, adding ascorbic acid (4:1 molar ratio to iron) to fortified cereal markedly increased iron absorption from ferric pyrophosphate and ferrous sulfate; food matrix and iron status strongly modified absorption.
In a randomized trial of T2DM patients, combined vitamin C (500 mg) and chromium (200 µg) for the treatment group (n=30) improved glycemic control (HbA1c), lipid profile, liver enzymes and BMI versus placebo.
In patients with primary biliary cirrhosis, a mixed oral antioxidant supplement including vitamin C did not improve fatigue or other liver-related symptoms compared with placebo.
In patients with primary biliary cirrhosis, a mixed oral antioxidant supplement including vitamin C did not improve fatigue or other liver-related symptoms compared with placebo.
Short-term high-dose combination antioxidants including vitamin C lowered systolic blood pressure (significantly in treated hypertensives) and increased circulating antioxidant levels.
Short-term high-dose combination antioxidants including vitamin C lowered systolic blood pressure (significantly in treated hypertensives) and increased circulating antioxidant levels.
High-dose vitamin C (1000 mg twice daily) increased urinary oxalate and stone-risk markers in a subset of participants.
High-dose vitamin C (1000 mg twice daily) increased urinary oxalate and stone-risk markers in a subset of participants.
Children conceived by ART given vitamins C (1 g) and E (400 IU) for 4 weeks showed improved NO levels, better brachial FMD and lower pulmonary artery pressure versus placebo (effects seen in ART children only).
Patients with IgA nephropathy had more oxidative damage and lower antioxidant levels including vitamin C than healthy volunteers.
Anemic children given iron/folate improved hemoglobin; adding vitamins A and C helped restore iron stores faster.
Increasing fruit and vegetable intake raised dietary and biomarker vitamin C levels in adults at increased CVD risk.
A 4-month RCT of an antioxidant cocktail including 1 g vitamin C reduced inflammatory and oxidative biomarkers (notably TNF-α and cystine) in colorectal adenoma patients.
Resistance training with whey increased some antioxidant markers (including vitamin C) and improved some lipid/HDL measures in overweight young men.
Yoga and sham-yoga produced similar improvements in many markers in T2DM; only reduced glutathione improved more with yoga, and vitamin C changed within groups but not between groups.
Three months of community yoga lowered oxidative stress (MDA) and improved BMI, waist, systolic BP and fasting glucose but did not change vitamin C levels.
Resistance training with whey increased some antioxidant markers (including vitamin C) and improved some lipid/HDL measures in overweight young men.
Randomized 16-week trial showing that eating vitamin C–rich gold kiwifruit with iron-fortified cereal improves iron status in women with low iron stores.
Omega-3 or vitamins E+C during 3 months of strength training changed concentrations of some B-vitamins and redox aminothiols in older men.
Omega-3 or vitamins E+C during 3 months of strength training changed concentrations of some B-vitamins and redox aminothiols in older men.
Large multicenter randomized trial showing no reduction in preeclampsia or related adverse outcomes with high-dose vitamin C + E started early in pregnancy.
Large multicenter randomized trial showing no reduction in preeclampsia or related adverse outcomes with high-dose vitamin C + E started early in pregnancy.
In patients receiving non-surgical periodontal therapy, a 4‑week free-sugar avoidance led to greater reductions in bleeding on probing and periodontal inflamed surface area and increased dietary vitamin C intake compared with control.
Randomized crossover in children: orange juice (25 mg ascorbic acid) increased absorption of ferrous fumarate compared with apple juice (no ascorbic acid).
Randomized crossover in children: orange juice (25 mg ascorbic acid) increased absorption of ferrous fumarate compared with apple juice (no ascorbic acid).
Prospective cohort of male smokers found no association between dietary or supplemental vitamin C intake and bladder cancer risk over median 11-year follow-up.
Prospective cohort of male smokers found no association between dietary or supplemental vitamin C intake and bladder cancer risk over median 11-year follow-up.
Randomized double-blind 4-week trial comparing isoflavones, vitamins C+E, and placebo; vitamin C+E did not change bone resorption marker.
Randomized double-blind 4-week trial comparing isoflavones, vitamins C+E, and placebo; vitamin C+E did not change bone resorption marker.
Large randomized double-blind trial: multivitamins including vitamin C reduced presumptive clinical malaria but increased any malaria parasitemia.
Large randomized double-blind trial: multivitamins including vitamin C reduced presumptive clinical malaria but increased any malaria parasitemia.
3-year placebo-controlled intervention with calcium plus antioxidants (including vitamin C) showed no overall effect on adenoma growth but suggested reduced new adenoma formation in some subgroups.
3-year placebo-controlled intervention with calcium plus antioxidants (including vitamin C) showed no overall effect on adenoma growth but suggested reduced new adenoma formation in some subgroups.
Double-blind randomized trial giving high-dose IV and cardioplegia vitamin C in CABG patients found no change in cardiac enzymes but improved ejection fraction and shorter ICU stay.
Double-blind randomized trial giving high-dose IV and cardioplegia vitamin C in CABG patients found no change in cardiac enzymes but improved ejection fraction and shorter ICU stay.
In patients with non-healing diabetic foot ulcers, adding oral vitamins E and C to PRP-FG dressing increased wound closures and reduced oxidative/inflammatory markers over 8 weeks.
In patients with non-healing diabetic foot ulcers, adding oral vitamins E and C to PRP-FG dressing increased wound closures and reduced oxidative/inflammatory markers over 8 weeks.
In patients with non-healing diabetic foot ulcers, adding oral vitamins E and C to PRP-FG dressing increased wound closures and reduced oxidative/inflammatory markers over 8 weeks.
Preoperative ascorbic acid did not prevent the surgical stress hormone changes; some hormones transiently rose after surgery.
Preoperative ascorbic acid did not prevent the surgical stress hormone changes; some hormones transiently rose after surgery.
Preoperative ascorbic acid did not prevent the surgical stress hormone changes; some hormones transiently rose after surgery.
Changing cows' diet to alter cheese fat composition raised blood vitamins C and E and lowered oxidized LDL and myristic acid in healthy volunteers after 4 weeks.
New parenteral nutrition with multivitamins increased blood vitamin C and was safely tolerated in healthy volunteers.
A 6-month randomized dietary intervention (Mediterranean Diet) in breast cancer survivors increased blood vitamin C and improved body composition and glycemic measures compared with control.
Changing cows' diet to alter cheese fat composition raised blood vitamins C and E and lowered oxidized LDL and myristic acid in healthy volunteers after 4 weeks.
Changing cows' diet to alter cheese fat composition raised blood vitamins C and E and lowered oxidized LDL and myristic acid in healthy volunteers after 4 weeks.
In this randomized phase II trial, combinations including 2-L PEG with ascorbic acid (split-dose) achieved high rates of successful bowel cleansing for colonoscopy.
In this randomized phase II trial, combinations including 2-L PEG with ascorbic acid (split-dose) achieved high rates of successful bowel cleansing for colonoscopy.
In this randomized phase II trial, combinations including 2-L PEG with ascorbic acid (split-dose) achieved high rates of successful bowel cleansing for colonoscopy.
Randomized study testing ascorbic acid, beta carotene, and allicin with/without standard therapy for H. pylori eradication; ascorbic acid showed no benefit.
Randomized study testing ascorbic acid, beta carotene, and allicin with/without standard therapy for H. pylori eradication; ascorbic acid showed no benefit.
Workers exposed to solvents received an antioxidant vitamin mix (A, C, E, selenium); cytogenetic markers improved after 1 month of supplementation.
Workers exposed to solvents received an antioxidant vitamin mix (A, C, E, selenium); cytogenetic markers improved after 1 month of supplementation.
Perioperative multi-antioxidant regimen (including vitamin C) did not change gut permeability after lower torso ischemia compared with standard care.
In septic shock patients, baseline plasma ascorbic acid levels did not predict hydrocortisone treatment effect or 90-day mortality.
In septic shock patients, baseline plasma ascorbic acid levels did not predict hydrocortisone treatment effect or 90-day mortality.
Young children received cereal fortified with iron and ascorbic acid (3:1 molar ratio); no difference between iron compounds in maintaining hemoglobin >105 g/L.
Large randomized placebo-controlled trial in a high-risk Chinese population; long-term (7.3 years) vitamin supplementation (included 250 mg vitamin C with vitamin E and selenium) reduced gastric cancer incidence and gastric cancer mortality over 22.3 years.
Long-term combined vitamin supplement (including vitamin C) vs placebo had no beneficial effect on precancerous gastric lesions or gastric cancer incidence.
Long-term follow-up of a randomized, placebo-controlled trial: combined vitamin treatment (vitamins C and E plus selenium) did not reduce overall gastric cancer incidence but was associated with fewer gastric or esophageal cancer deaths.
Long-term follow-up of a randomized, placebo-controlled trial: combined vitamin treatment (vitamins C and E plus selenium) did not reduce overall gastric cancer incidence but was associated with fewer gastric or esophageal cancer deaths.
Large randomized placebo-controlled trial in a high-risk Chinese population; long-term (7.3 years) vitamin supplementation (included 250 mg vitamin C with vitamin E and selenium) reduced gastric cancer incidence and gastric cancer mortality over 22.3 years.
Long-term follow-up of a randomized, placebo-controlled trial: combined vitamin treatment (vitamins C and E plus selenium) did not reduce overall gastric cancer incidence but was associated with fewer gastric or esophageal cancer deaths.
Two small controlled studies in adults ≥70 showed statins lowered LDL but adding antioxidant vitamins (including vitamin C in one arm) did not improve brachial artery flow-mediated or nitroglycerin-mediated vasodilation.
Two small controlled studies in adults ≥70 showed statins lowered LDL but adding antioxidant vitamins (including vitamin C in one arm) did not improve brachial artery flow-mediated or nitroglycerin-mediated vasodilation.
Randomized placebo-controlled trial of micronutrient sprinkles (including vitamins A,C,D3, zinc, iron, folic acid) in Cambodian infants; outcomes on fatty acid status reported but vitamin D effect not isolated.
Randomized placebo-controlled trial of micronutrient sprinkles (including vitamins A,C,D3, zinc, iron, folic acid) in Cambodian infants; outcomes on fatty acid status reported but vitamin D effect not isolated.
Randomized placebo-controlled trial of micronutrient sprinkles (including vitamins A,C,D3, zinc, iron, folic acid) in Cambodian infants; outcomes on fatty acid status reported but vitamin D effect not isolated.
High-dose antioxidant formulation including vitamin C plus zinc reduced progression to advanced AMD and reduced risk of moderate vision loss compared with placebo.
High-dose antioxidant formulation including vitamin C plus zinc reduced progression to advanced AMD and reduced risk of moderate vision loss compared with placebo.
A 4-month high-antioxidant diet (designed to raise vitamins A, C and E) increased plasma and leukocyte vitamin C, boosted antioxidant enzyme activities, and lowered lipid oxidative markers in women with endometriosis.
In CAD patients on simvastatin+niacin, adding antioxidant vitamins (including vitamin C) blunted the favorable increases in HDL metrics observed with lipid therapy alone.
In CAD patients on simvastatin+niacin, adding antioxidant vitamins (including vitamin C) blunted the favorable increases in HDL metrics observed with lipid therapy alone.
Three-year supplementation with vitamin C (750 mg/day) plus vitamin E and beta-carotene did not significantly change progression or regression rates of precancerous gastric lesions compared with placebo.
Three-year supplementation with vitamin C (750 mg/day) plus vitamin E and beta-carotene did not significantly change progression or regression rates of precancerous gastric lesions compared with placebo.
In nonadvanced AMD patients, one-year supplementation including vitamin C and carotenoids improved central retinal electrophysiologic responses compared with no supplementation.
An enteral diet enriched with EPA, GLA, and elevated antioxidants lowered 28-day mortality and improved ventilator- and ICU-free days in mechanically ventilated severe sepsis/septic shock patients.
An enteral diet enriched with EPA, GLA, and elevated antioxidants lowered 28-day mortality and improved ventilator- and ICU-free days in mechanically ventilated severe sepsis/septic shock patients.
An enteral diet enriched with EPA, GLA, and elevated antioxidants lowered 28-day mortality and improved ventilator- and ICU-free days in mechanically ventilated severe sepsis/septic shock patients.
In postmenopausal women, vitamins C and E altered angiographic progression of coronary atherosclerosis in a manner dependent on haptoglobin genotype — beneficial in Hp1-1 (especially diabetics) and possibly harmful in Hp2-2 diabetics.
In postmenopausal women, vitamins C and E altered angiographic progression of coronary atherosclerosis in a manner dependent on haptoglobin genotype — beneficial in Hp1-1 (especially diabetics) and possibly harmful in Hp2-2 diabetics.
In postmenopausal women, vitamins C and E altered angiographic progression of coronary atherosclerosis in a manner dependent on haptoglobin genotype — beneficial in Hp1-1 (especially diabetics) and possibly harmful in Hp2-2 diabetics.
Giving oral antioxidant capsules around ESWL reduced markers of oxidative stress and short-term kidney injury compared with no antioxidants.
Giving oral antioxidant capsules around ESWL reduced markers of oxidative stress and short-term kidney injury compared with no antioxidants.
Perioperative micronutrient supplementation (including vitamin C) had little effect on muscle strength but preserved self-rated physical function compared with placebo.
Perioperative micronutrient supplementation (including vitamin C) had little effect on muscle strength but preserved self-rated physical function compared with placebo.
In patients with prior poor preparation, 4-L split-dose PEG cleansing was superior to 2-L PEG plus ascorbic acid; adding ascorbic acid made the lower-volume prep less effective.
Large randomized trial of high-dose antioxidants and zinc in older adults; zinc assignment was associated with lower mortality but no clear mortality benefit reported for antioxidant treatment.
Large randomized trial of high-dose antioxidants and zinc in older adults; zinc assignment was associated with lower mortality but no clear mortality benefit reported for antioxidant treatment.
Large randomized trial of high-dose antioxidants and zinc in older adults; zinc assignment was associated with lower mortality but no clear mortality benefit reported for antioxidant treatment.
Crossover test-meal study in nonanemic women showing added ascorbic acid (31.4 mg) increases iron absorption, but the enhancing effect is smaller in overweight/obese women.
Crossover test-meal study in nonanemic women showing added ascorbic acid (31.4 mg) increases iron absorption, but the enhancing effect is smaller in overweight/obese women.
Crossover test-meal study in nonanemic women showing added ascorbic acid (31.4 mg) increases iron absorption, but the enhancing effect is smaller in overweight/obese women.
Large double-blind RCT of daily multivitamins in pregnant HIV-negative women showed reduced low birth weight and small-for-gestational-age births; vitamin C was part of the multivitamin regimen but not isolated.
In HIV-infected pregnant women, multivitamin supplements (including vitamin C) at single versus multiple RDA doses produced similar pregnancy outcomes.
Large double-blind RCT of daily multivitamins in pregnant HIV-negative women showed reduced low birth weight and small-for-gestational-age births; vitamin C was part of the multivitamin regimen but not isolated.
Large double-blind RCT of daily multivitamins in pregnant HIV-negative women showed reduced low birth weight and small-for-gestational-age births; vitamin C was part of the multivitamin regimen but not isolated.
In healthy volunteers, a 1-month high-heat-treated diet reduced insulin sensitivity and lowered plasma vitamins (including vitamin C) while increasing blood lipids.
In healthy volunteers, a 1-month high-heat-treated diet reduced insulin sensitivity and lowered plasma vitamins (including vitamin C) while increasing blood lipids.
In this 13-year cohort study, higher vitamin C intake was positively associated with verbal memory performance but study design is observational.
Pooled post-hoc analysis of AREDS and AREDS2 found that antioxidant-containing formulations (including 500 mg vitamin C) slowed GA progression toward the central macula but did not change GA area.
Pooled post-hoc analysis of AREDS and AREDS2 found that antioxidant-containing formulations (including 500 mg vitamin C) slowed GA progression toward the central macula but did not change GA area.
Pooled post-hoc analysis of AREDS and AREDS2 found that antioxidant-containing formulations (including 500 mg vitamin C) slowed GA progression toward the central macula but did not change GA area.
In a large randomized trial and follow-up, the AREDS antioxidant/zinc formulation (including vitamin C) reduced risk of progression to advanced and neovascular AMD and lowered risk of moderate vision loss over 10 years.
In a large randomized trial and follow-up, the AREDS antioxidant/zinc formulation (including vitamin C) reduced risk of progression to advanced and neovascular AMD and lowered risk of moderate vision loss over 10 years.
In a large randomized trial and follow-up, the AREDS antioxidant/zinc formulation (including vitamin C) reduced risk of progression to advanced and neovascular AMD and lowered risk of moderate vision loss over 10 years.
Children conceived by ART given vitamins C (1 g) and E (400 IU) for 4 weeks showed improved NO levels, better brachial FMD and lower pulmonary artery pressure versus placebo (effects seen in ART children only).
Long-term combined vitamin supplement (including vitamin C) vs placebo had no beneficial effect on precancerous gastric lesions or gastric cancer incidence.
Long-term combined vitamin supplement (including vitamin C) vs placebo had no beneficial effect on precancerous gastric lesions or gastric cancer incidence.
A 4-month RCT of an antioxidant cocktail including 1 g vitamin C reduced inflammatory and oxidative biomarkers (notably TNF-α and cystine) in colorectal adenoma patients.
A 4-month RCT of an antioxidant cocktail including 1 g vitamin C reduced inflammatory and oxidative biomarkers (notably TNF-α and cystine) in colorectal adenoma patients.
Perioperative supplementation with n-3 PUFAs plus vitamins C and E reduced postoperative atrial fibrillation more in older patients and increased atrial glutathione peroxidase activity in those >60 years.
Daily multivitamin at 100% RDI (including vitamin D among others) did not reduce number or duration of recurrent mouth ulcers compared with placebo over up to 365 days.
Daily multivitamin at 100% RDI (including vitamin D among others) did not reduce number or duration of recurrent mouth ulcers compared with placebo over up to 365 days.
Daily multivitamin at 100% RDI (including vitamin D among others) did not reduce number or duration of recurrent mouth ulcers compared with placebo over up to 365 days.
Ascorbic acid (vitamin C) added to fortified sorghum meals substantially increased iron absorption in young women, overcoming polyphenol inhibition.
Ascorbic acid (vitamin C) added to fortified sorghum meals substantially increased iron absorption in young women, overcoming polyphenol inhibition.
Ascorbic acid (vitamin C) added to fortified sorghum meals substantially increased iron absorption in young women, overcoming polyphenol inhibition.
8-week antioxidant supplement (including vitamin C) reduced insulin resistance and some inflammation and oxidative stress in overweight young adults.
8-week antioxidant supplement (including vitamin C) reduced insulin resistance and some inflammation and oxidative stress in overweight young adults.
8-week antioxidant supplement (including vitamin C) reduced insulin resistance and some inflammation and oxidative stress in overweight young adults.
Giving IV vitamin C during coronary stenting reduced markers of oxidative stress and lowered platelet and soluble CD40L compared with placebo.
Giving IV vitamin C during coronary stenting reduced markers of oxidative stress and lowered platelet and soluble CD40L compared with placebo.
Giving IV vitamin C during coronary stenting reduced markers of oxidative stress and lowered platelet and soluble CD40L compared with placebo.
Large randomized population trial of multiple vitamin/mineral regimens found some regimens reduced overall or cancer mortality; vitamin C (with molybdenum) was associated with decreased stroke mortality.
Large randomized population trial of multiple vitamin/mineral regimens found some regimens reduced overall or cancer mortality; vitamin C (with molybdenum) was associated with decreased stroke mortality.
Large randomized population trial of multiple vitamin/mineral regimens found some regimens reduced overall or cancer mortality; vitamin C (with molybdenum) was associated with decreased stroke mortality.
Giving HIV-infected mothers multivitamins (including B12) during pregnancy and postpartum improved their children's weight at 24 months.
Daily low-dose MNP containing bioavailable iron and 2.5 mg zinc reduced iron and zinc deficiencies and modestly improved weight-for-age over 23 weeks.
Daily low-dose MNP containing bioavailable iron and 2.5 mg zinc reduced iron and zinc deficiencies and modestly improved weight-for-age over 23 weeks.
Daily low-dose MNP containing bioavailable iron and 2.5 mg zinc reduced iron and zinc deficiencies and modestly improved weight-for-age over 23 weeks.
In mild–moderate Alzheimer patients, combined antioxidant treatment including vitamin C lowered a CSF oxidative stress marker but was associated with faster cognitive decline over 16 weeks.
In mild–moderate Alzheimer patients, combined antioxidant treatment including vitamin C lowered a CSF oxidative stress marker but was associated with faster cognitive decline over 16 weeks.
In mild–moderate Alzheimer patients, combined antioxidant treatment including vitamin C lowered a CSF oxidative stress marker but was associated with faster cognitive decline over 16 weeks.
In extremely preterm infants, complete photoprotection of PN reduced peroxide contamination and preserved ascorbic acid in PN, lowering urinary peroxide levels in the first week.
In extremely preterm infants, complete photoprotection of PN reduced peroxide contamination and preserved ascorbic acid in PN, lowering urinary peroxide levels in the first week.
In extremely preterm infants, complete photoprotection of PN reduced peroxide contamination and preserved ascorbic acid in PN, lowering urinary peroxide levels in the first week.
Weekly or daily micronutrient supplements including zinc raised hemoglobin, serum zinc, and retinol versus placebo; growth improved only in children who were stunted at baseline.
Weekly or daily micronutrient supplements including zinc raised hemoglobin, serum zinc, and retinol versus placebo; growth improved only in children who were stunted at baseline.
Small randomized trial in men undergoing hernia repair found perioperative supplementation (arginine, glutamine, vitamin C, zinc) increased markers of collagen synthesis in wound fluid during the first 1–2 days after surgery.
Small randomized trial in men undergoing hernia repair found perioperative supplementation (arginine, glutamine, vitamin C, zinc) increased markers of collagen synthesis in wound fluid during the first 1–2 days after surgery.
Randomized 4-arm safety/tolerability trial (40 completers) testing daily consumption (0–3 stick packs/day for 4 weeks) of an allulose–amino acid–electrolyte powder; product was generally well tolerated with no clinically meaningful adverse changes in labs over 4 weeks.
Randomized 4-arm safety/tolerability trial (40 completers) testing daily consumption (0–3 stick packs/day for 4 weeks) of an allulose–amino acid–electrolyte powder; product was generally well tolerated with no clinically meaningful adverse changes in labs over 4 weeks.
Randomized 4-arm safety/tolerability trial (40 completers) testing daily consumption (0–3 stick packs/day for 4 weeks) of an allulose–amino acid–electrolyte powder; product was generally well tolerated with no clinically meaningful adverse changes in labs over 4 weeks.
In patients with stage III/IV periodontitis, a 2-month multinutrient supplement (including vitamin C) given with scaling/root planing produced some additional improvement in pocket depth and bleeding compared with placebo.
In patients with stage III/IV periodontitis, a 2-month multinutrient supplement (including vitamin C) given with scaling/root planing produced some additional improvement in pocket depth and bleeding compared with placebo.
Four-week antioxidant regimens including ascorbic acid increased plasma ascorbic acid but did not change measures of mononuclear leukocyte DNA damage in smokers or nonsmokers.
A 2-L PEG solution plus ascorbic acid cleaned the colon as well as 4-L PEG, with better taste and higher patient compliance.
A 2-L PEG solution plus ascorbic acid cleaned the colon as well as 4-L PEG, with better taste and higher patient compliance.
Supplementation with a fruit-and-vegetable concentrate increased plasma vitamin C and folate and modestly lowered homocysteine in men.
Ascorbic acid acutely potentiated acetylcholine-induced vasodilation at baseline, but after aliskiren treatment ascorbic acid no longer enhanced endothelium-dependent relaxation.
Low-volume PEG with ascorbic acid cleans as well as standard PEG, tastes better, and split dosing gives the best cleansing.
Long-term combined antioxidant supplementation including 120 mg vitamin C showed a small improvement in episodic/verbal memory, especially in nonsmokers or those with low baseline vitamin C.
Long-term combined antioxidant supplementation including 120 mg vitamin C showed a small improvement in episodic/verbal memory, especially in nonsmokers or those with low baseline vitamin C.
Long-term combined antioxidant supplementation including 120 mg vitamin C showed a small improvement in episodic/verbal memory, especially in nonsmokers or those with low baseline vitamin C.
PEG with ascorbate components (2 L) produced substantially higher successful bowel cleansing than sodium phosphate and was well tolerated.
PEG with ascorbate components (2 L) produced substantially higher successful bowel cleansing than sodium phosphate and was well tolerated.
Daily antioxidant supplement (included ascorbic acid) given to children, young and elderly improved oxidative markers and erythrocyte membrane fluidity in young/elderly but not children.
Acute ingestion of the pre-workout supplement (contains 70 mg methylcobalamin) increased short-term metabolism and improved cognitive scores and perceived energy with minimal safety signals in young trained adults.
Acute ingestion of the pre-workout supplement (contains 70 mg methylcobalamin) increased short-term metabolism and improved cognitive scores and perceived energy with minimal safety signals in young trained adults.
Acute ingestion of the pre-workout supplement (contains 70 mg methylcobalamin) increased short-term metabolism and improved cognitive scores and perceived energy with minimal safety signals in young trained adults.
Eight-week randomized, double-blind trial (supplement contains 70 mg methylcobalamin) found some within-group gains in cognition and strength with PWS, but no consistent between-group advantages in body composition or most performance outcomes; supplements were well tolerated.
Eight-week randomized, double-blind trial (supplement contains 70 mg methylcobalamin) found some within-group gains in cognition and strength with PWS, but no consistent between-group advantages in body composition or most performance outcomes; supplements were well tolerated.
Eight-week randomized, double-blind trial (supplement contains 70 mg methylcobalamin) found some within-group gains in cognition and strength with PWS, but no consistent between-group advantages in body composition or most performance outcomes; supplements were well tolerated.
Brief behavioural counselling increased fruit and vegetable intake versus nutrition education; plasma beta-carotene and alpha-tocopherol rose but plasma ascorbic acid (vitamin C) did not change.
Brief behavioural counselling increased fruit and vegetable intake versus nutrition education; plasma beta-carotene and alpha-tocopherol rose but plasma ascorbic acid (vitamin C) did not change.
Lutein or lutein plus green tea supplements raised plasma lutein and ascorbic acid concentrations but did not change overall antioxidant activity or lipid peroxidation markers.
Warm blood cardioplegia reduced oxidative-stress markers and improved post-ischemic heart function; cold cardioplegia showed increased myocardial consumption of ascorbic acid.
Warm blood cardioplegia reduced oxidative-stress markers and improved post-ischemic heart function; cold cardioplegia showed increased myocardial consumption of ascorbic acid.
Warm blood cardioplegia reduced oxidative-stress markers and improved post-ischemic heart function; cold cardioplegia showed increased myocardial consumption of ascorbic acid.
A 4-week blueberry/apple juice (providing 16 mg ascorbic acid/day) raised plasma antioxidants and reduced some oxidative DNA damage but increased another DNA adduct type; effects varied by genotype.
A 4-week blueberry/apple juice (providing 16 mg ascorbic acid/day) raised plasma antioxidants and reduced some oxidative DNA damage but increased another DNA adduct type; effects varied by genotype.
Nutrition education classes reduced fat intake and increased fiber and ascorbic acid (vitamin C) intake among postmenopausal women, especially in those motivated to change.
An 18‑week worksite plant‑based dietary intervention increased reported vitamin C intake and other micronutrients among completers.
Nutrition education classes reduced fat intake and increased fiber and ascorbic acid (vitamin C) intake among postmenopausal women, especially in those motivated to change.
In institutionalized elderly, daily low‑dose supplements (including ascorbic acid in the vitamin arm) corrected deficiencies but vitamins did not improve cell‑mediated immunity and the vitamin arm had lower influenza antibody titers; trace elements improved antibody response.
In institutionalized elderly, daily low‑dose supplements (including ascorbic acid in the vitamin arm) corrected deficiencies but vitamins did not improve cell‑mediated immunity and the vitamin arm had lower influenza antibody titers; trace elements improved antibody response.
In institutionalized elderly, daily low‑dose supplements (including ascorbic acid in the vitamin arm) corrected deficiencies but vitamins did not improve cell‑mediated immunity and the vitamin arm had lower influenza antibody titers; trace elements improved antibody response.
Moviprep (PEG + ascorbic acid) produced a higher rate of top-quality bowel cleansing and less vomiting than Phosphoral, with similar overall acceptable cleansing rates.
Moviprep (PEG + ascorbic acid) produced a higher rate of top-quality bowel cleansing and less vomiting than Phosphoral, with similar overall acceptable cleansing rates.
Moviprep (PEG + ascorbic acid) produced a higher rate of top-quality bowel cleansing and less vomiting than Phosphoral, with similar overall acceptable cleansing rates.
A 6-month randomized placebo-controlled pilot trial found the micronutrient mix (including vitamin C) reduced gum bleeding and more patients met the defined improvement criteria than placebo.
A 6-month randomized placebo-controlled pilot trial found the micronutrient mix (including vitamin C) reduced gum bleeding and more patients met the defined improvement criteria than placebo.
In Marines completing 24 days of cold-weather training, oxidative stress markers rose in all subjects and the antioxidant mix (including vitamin C) did not significantly reduce stress for the group as a whole.
In Marines completing 24 days of cold-weather training, oxidative stress markers rose in all subjects and the antioxidant mix (including vitamin C) did not significantly reduce stress for the group as a whole.
Lutein or lutein plus green tea supplements raised plasma lutein and ascorbic acid concentrations but did not change overall antioxidant activity or lipid peroxidation markers.
In 299 children, a low-volume PEG with ascorbic acid (PEG-Asc) provided bowel cleansing that was noninferior to high-volume PEG and was among effective low-volume options.
In 299 children, a low-volume PEG with ascorbic acid (PEG-Asc) provided bowel cleansing that was noninferior to high-volume PEG and was among effective low-volume options.
In ~54 completers with CKD, lanthanum carbonate lowered urinary phosphate excretion but did not improve endothelial function or reduce oxidative stress; supraphysiologic ascorbic acid infusion acutely increased FMD during testing but lanthanum had no effect on oxidative markers.
In ~54 completers with CKD, lanthanum carbonate lowered urinary phosphate excretion but did not improve endothelial function or reduce oxidative stress; supraphysiologic ascorbic acid infusion acutely increased FMD during testing but lanthanum had no effect on oxidative markers.
In ~54 completers with CKD, lanthanum carbonate lowered urinary phosphate excretion but did not improve endothelial function or reduce oxidative stress; supraphysiologic ascorbic acid infusion acutely increased FMD during testing but lanthanum had no effect on oxidative markers.
Dietary counselling in pregnant women increased reported vitamin C (ascorbic acid) intake by about 20 mg/day compared with controls.
Dietary counselling in pregnant women increased reported vitamin C (ascorbic acid) intake by about 20 mg/day compared with controls.
Dietary counselling in pregnant women increased reported vitamin C (ascorbic acid) intake by about 20 mg/day compared with controls.
In 1000 outpatients, a bowel preparation containing ascorbic acid cleaned colons as effectively as other split-dose regimens, with no clear tolerability advantage.
In 1000 outpatients, a bowel preparation containing ascorbic acid cleaned colons as effectively as other split-dose regimens, with no clear tolerability advantage.
In 1000 outpatients, a bowel preparation containing ascorbic acid cleaned colons as effectively as other split-dose regimens, with no clear tolerability advantage.
The Cyclo 3 Fort product containing ascorbic acid reduced symptoms and leg size more than rutoside and was safe.
A combination product containing ascorbic acid improved symptoms and reduced leg size more than rutoside and was well tolerated.
A combination product containing ascorbic acid improved symptoms and reduced leg size more than rutoside and was well tolerated.
The Cyclo 3 Fort product containing ascorbic acid reduced symptoms and leg size more than rutoside and was safe.
A combination product containing ascorbic acid improved symptoms and reduced leg size more than rutoside and was well tolerated.
The Cyclo 3 Fort product containing ascorbic acid reduced symptoms and leg size more than rutoside and was safe.
Bowel prep containing ascorbic acid cleaned the colon better and led to more adenomas being detected, with similar tolerability.
Bowel prep containing ascorbic acid cleaned the colon better and led to more adenomas being detected, with similar tolerability.
In a double-blind randomized factorial trial, antioxidant vitamins including 150 mg ascorbic acid increased LDL resistance to ex vivo oxidation over 8 weeks compared with placebo; B-group vitamins did not have this antioxidant effect.
In postmenopausal women, estrogen treatment enabled exercise to improve endothelial function; intravenous ascorbic acid infusion increased endothelial function in certain groups.
In postmenopausal women, estrogen treatment enabled exercise to improve endothelial function; intravenous ascorbic acid infusion increased endothelial function in certain groups.
Using buffers (one containing ascorbic acid) with the oral cholera vaccine increased serologic responses compared with saline; the CeraVacx buffer produced the largest rises.
Using buffers (one containing ascorbic acid) with the oral cholera vaccine increased serologic responses compared with saline; the CeraVacx buffer produced the largest rises.
Using buffers (one containing ascorbic acid) with the oral cholera vaccine increased serologic responses compared with saline; the CeraVacx buffer produced the largest rises.
Large randomized trial where a combined antioxidant supplement (including 120 mg ascorbic acid daily) showed decreased cancer incidence and mortality in men during intervention, but these benefits were no longer evident after 5 years off supplementation.
Large randomized trial where a combined antioxidant supplement (including 120 mg ascorbic acid daily) showed decreased cancer incidence and mortality in men during intervention, but these benefits were no longer evident after 5 years off supplementation.
Large randomized trial where a combined antioxidant supplement (including 120 mg ascorbic acid daily) showed decreased cancer incidence and mortality in men during intervention, but these benefits were no longer evident after 5 years off supplementation.
Pregnant women receiving L. plantarum 299v capsules (which included low-dose iron, 12 mg ascorbic acid and folic acid) had smaller decreases in ferritin and hemoglobin and lower prevalence of iron deficiency and iron-deficiency anemia in late pregnancy compared with placebo.
Pregnant women receiving L. plantarum 299v capsules (which included low-dose iron, 12 mg ascorbic acid and folic acid) had smaller decreases in ferritin and hemoglobin and lower prevalence of iron deficiency and iron-deficiency anemia in late pregnancy compared with placebo.
Pregnant women receiving L. plantarum 299v capsules (which included low-dose iron, 12 mg ascorbic acid and folic acid) had smaller decreases in ferritin and hemoglobin and lower prevalence of iron deficiency and iron-deficiency anemia in late pregnancy compared with placebo.
Various iron delivery strategies (including a fortified water containing iron, zinc and ascorbic acid) all increased hemoglobin in anemic children over 4 months; supplements (iron ± other micronutrients) produced larger Hb increases than fortified complementary food.
Various iron delivery strategies (including a fortified water containing iron, zinc and ascorbic acid) all increased hemoglobin in anemic children over 4 months; supplements (iron ± other micronutrients) produced larger Hb increases than fortified complementary food.
Various iron delivery strategies (including a fortified water containing iron, zinc and ascorbic acid) all increased hemoglobin in anemic children over 4 months; supplements (iron ± other micronutrients) produced larger Hb increases than fortified complementary food.
Large randomized trial tested four supplement combinations (one included ascorbic acid + molybdenum) versus placebo for 5.25 years and found no reduction in lung cancer mortality.
Post-trial follow-up of SU.VI.MAX participants who had taken daily antioxidant supplements (including 120 mg ascorbic acid) found that supplementation increased skin cancer risk in women during the supplementation period but no residual increased risk was evident in the 5 years after stopping.
Post-trial follow-up of SU.VI.MAX participants who had taken daily antioxidant supplements (including 120 mg ascorbic acid) found that supplementation increased skin cancer risk in women during the supplementation period but no residual increased risk was evident in the 5 years after stopping.
In hemodialysis patients, an antioxidant cocktail that included vitamin B12 did not change markers of oxidative stress or inflammation over 8 weeks.
Large randomized trial tested four vitamin/mineral factor combinations (one factor included ascorbic acid + molybdenum) versus placebo for ~5 years and found no overall reduction in primary liver cancer mortality, though some subgroup effects were noted.
Large randomized trial tested four vitamin/mineral factor combinations (one factor included ascorbic acid + molybdenum) versus placebo for ~5 years and found no overall reduction in primary liver cancer mortality, though some subgroup effects were noted.
Double-blind controlled trial in overweight older men compared 5 weeks of Enzogenol+vitamin C versus vitamin C alone; cognitive response speed improved with Enzogenol+vitamin C while vitamin C alone produced no improvements.
Double-blind controlled trial in overweight older men compared 5 weeks of Enzogenol+vitamin C versus vitamin C alone; cognitive response speed improved with Enzogenol+vitamin C while vitamin C alone produced no improvements.
In 40 septic shock patients, 3 days of high‑dose IV vitamin C raised blood vitamin C but did not reduce increases in protein oxidative damage.
Among 619 men randomized to the vitamin C arm (500 mg/day), 70% had laboratory-confirmed SARS-CoV-2 infection; vitamin C served as the comparator and did not protect against infection in this setting.
Among 619 men randomized to the vitamin C arm (500 mg/day), 70% had laboratory-confirmed SARS-CoV-2 infection; vitamin C served as the comparator and did not protect against infection in this setting.
In 91 power-plant workers, 1000 mg/day vitamin C for 3 months reduced several proinflammatory cytokines compared with control.
In 91 power-plant workers, 1000 mg/day vitamin C for 3 months reduced several proinflammatory cytokines compared with control.
In children 4–12 years, the vitamin C control group had more cold days, more respiratory infections and more antibiotic use than the Echinacea group over 4 months.
In children 4–12 years, the vitamin C control group had more cold days, more respiratory infections and more antibiotic use than the Echinacea group over 4 months.
In children 4–12 years, the vitamin C control group had more cold days, more respiratory infections and more antibiotic use than the Echinacea group over 4 months.
In healthy adults a high-salt diet reduced skin microvascular vasodilation; the study tested local infusions including ascorbic acid but ascorbic-acid–specific results are not fully reported in the excerpt.
A 4-week antioxidant-containing drink (included vitamin C) increased plasma antioxidant capacity and serum selenium and increased faecal Lactobacillus plantarum counts.
A 4-week antioxidant-containing drink (included vitamin C) increased plasma antioxidant capacity and serum selenium and increased faecal Lactobacillus plantarum counts.
A 4-week antioxidant-containing drink (included vitamin C) increased plasma antioxidant capacity and serum selenium and increased faecal Lactobacillus plantarum counts.
In RA patients, shifting to a Mediterranean diet increased reported vitamin C intake but plasma vitamin C levels were unchanged at 12 weeks; baseline vitamin C correlated inversely with inflammation markers.
Six weeks of mixed antioxidant (primarily vitamins C & E) supplementation raised plasma vitamin C but did not improve muscle function recovery after damaging exercise and had mixed effects on oxidative/inflammatory markers.
Six weeks of mixed antioxidant (primarily vitamins C & E) supplementation raised plasma vitamin C but did not improve muscle function recovery after damaging exercise and had mixed effects on oxidative/inflammatory markers.
Six weeks of mixed antioxidant (primarily vitamins C & E) supplementation raised plasma vitamin C but did not improve muscle function recovery after damaging exercise and had mixed effects on oxidative/inflammatory markers.
In a large RCT where women with BV received either metronidazole or oral vitamin C, vitamin C recipients did not show increased preterm delivery and in one high-risk subgroup had lower preterm rates than the metronidazole group.
In a large RCT where women with BV received either metronidazole or oral vitamin C, vitamin C recipients did not show increased preterm delivery and in one high-risk subgroup had lower preterm rates than the metronidazole group.
A 6-month randomized dietary intervention (Mediterranean Diet) in breast cancer survivors increased blood vitamin C and improved body composition and glycemic measures compared with control.
A 6-month randomized dietary intervention (Mediterranean Diet) in breast cancer survivors increased blood vitamin C and improved body composition and glycemic measures compared with control.
In septic shock patients, adding vitamin C and thiamine to hydrocortisone did not significantly reduce 28-day mortality but shortened shock duration and vasopressor use and reduced some adverse renal and fever outcomes.
In septic shock patients, adding vitamin C and thiamine to hydrocortisone did not significantly reduce 28-day mortality but shortened shock duration and vasopressor use and reduced some adverse renal and fever outcomes.
12-week double-blind RCT of an MVM (including vitamin D) increased vitamin C and zinc levels and reduced reported illness duration/severity, but did not change 25(OH) vitamin D or measured neutrophil functional assays.
12-week double-blind RCT of an MVM (including vitamin D) increased vitamin C and zinc levels and reduced reported illness duration/severity, but did not change 25(OH) vitamin D or measured neutrophil functional assays.
In a 4-week randomized study, adding mandarin juice (rich in vitamin C and other antioxidants) to a low-calorie diet in obese children reduced oxidative stress markers and greatly increased plasma vitamin C.
A multi-component nutraceutical (includes vitamin D among other ingredients) reduced lymphocyte counts, IL-6, and CRP and improved self-reported wellness in hospitalized elderly compared with untreated elderly controls.
Obese participants on a 3-month low-calorie, DRI-covering formula diet showed declines in cellular and serum vitamin C but an increase in leukocyte vitamin C; some vitamin C deficiency cases increased after the diet.
In a double‑blind randomized cross‑over trial of folic acid vs placebo, the renal plasma flow (RPF) response to an acute vitamin C infusion (+93 to +94 ml/min·m²) did not differ between treatment phases, indicating folic acid did not modify the vitamin C–sensitive component of renal oxidant stress.
In newly diagnosed type 2 diabetes patients, plasma vitamin C (biomarker of fruit/vegetable intake) rose modestly (+2.0 μmol/L) over 1 year and increases in plasma vitamin C were associated with small improvements in BMI, waist, HbA1c and modelled 10‑year CVD risk.
In newly diagnosed type 2 diabetes patients, plasma vitamin C (biomarker of fruit/vegetable intake) rose modestly (+2.0 μmol/L) over 1 year and increases in plasma vitamin C were associated with small improvements in BMI, waist, HbA1c and modelled 10‑year CVD risk.
In newly diagnosed type 2 diabetes patients, plasma vitamin C (biomarker of fruit/vegetable intake) rose modestly (+2.0 μmol/L) over 1 year and increases in plasma vitamin C were associated with small improvements in BMI, waist, HbA1c and modelled 10‑year CVD risk.
In newly diagnosed type 2 diabetes patients, plasma vitamin C (biomarker of fruit/vegetable intake) rose modestly (+2.0 μmol/L) over 1 year and increases in plasma vitamin C were associated with small improvements in BMI, waist, HbA1c and modelled 10‑year CVD risk.
Cross‑sectional study found vegetarians had higher plasma antioxidant status and higher plasma vitamin C (statistically significant) and lower LDL TBARS compared with nonvegetarians.
9-week randomized placebo-controlled trial comparing anthocyanin-rich juice vs a placebo beverage that was high in vitamin C; both drinks reduced DNA strand breaks and improved some lipid markers, likely due in part to high vitamin C content.
9-week randomized placebo-controlled trial comparing anthocyanin-rich juice vs a placebo beverage that was high in vitamin C; both drinks reduced DNA strand breaks and improved some lipid markers, likely due in part to high vitamin C content.
9-week randomized placebo-controlled trial comparing anthocyanin-rich juice vs a placebo beverage that was high in vitamin C; both drinks reduced DNA strand breaks and improved some lipid markers, likely due in part to high vitamin C content.
Two-week RCT increasing fruit & vegetable intake; participants given fresh FV (FVI) showed improved vitality, flourishing and motivation; vitamin C measured rose modestly but did not mediate psychological changes.
Two-week RCT increasing fruit & vegetable intake; participants given fresh FV (FVI) showed improved vitality, flourishing and motivation; vitamin C measured rose modestly but did not mediate psychological changes.
Two-week RCT increasing fruit & vegetable intake; participants given fresh FV (FVI) showed improved vitality, flourishing and motivation; vitamin C measured rose modestly but did not mediate psychological changes.
Randomized controlled study in children comparing massage+oral vitamin C, traditional Chinese medicines (huangqi + bear bile), and combination; TCM groups had larger decreases in recurrence and higher recovery rates than the vitamin C/massage group.
Randomized controlled study in children comparing massage+oral vitamin C, traditional Chinese medicines (huangqi + bear bile), and combination; TCM groups had larger decreases in recurrence and higher recovery rates than the vitamin C/massage group.
In 34 healthy adults, a liposomal multivitamin altered how some minerals and vitamins appeared in blood; serum calcium rose at 2 h after the liposomal MVM and some calcium PK markers (Tmax, absorption rate) differed; no side effects reported.
In 34 healthy adults, a liposomal multivitamin altered how some minerals and vitamins appeared in blood; serum calcium rose at 2 h after the liposomal MVM and some calcium PK markers (Tmax, absorption rate) differed; no side effects reported.
In 34 healthy adults, a liposomal multivitamin altered how some minerals and vitamins appeared in blood; serum calcium rose at 2 h after the liposomal MVM and some calcium PK markers (Tmax, absorption rate) differed; no side effects reported.
An 18‑week worksite plant‑based dietary intervention increased reported vitamin C intake and other micronutrients among completers.
A randomized, double‑blind phase II trial of ArtemiC oral spray (contains vitamin C plus other actives) in hospitalized COVID‑19 patients showed improved clinical scores (NEWS2) versus placebo.
A randomized, double‑blind phase II trial of ArtemiC oral spray (contains vitamin C plus other actives) in hospitalized COVID‑19 patients showed improved clinical scores (NEWS2) versus placebo.
A randomized, double‑blind phase II trial of ArtemiC oral spray (contains vitamin C plus other actives) in hospitalized COVID‑19 patients showed improved clinical scores (NEWS2) versus placebo.
Eight-week randomized trial in 72 middle-aged subjects with cardiovascular risk factors: moderate berry consumption improved platelet function, raised HDL, and lowered systolic blood pressure in those with high baseline BP.
A 6‑month lifestyle intervention led to weight loss and increased physical activity; measured vitamin C intake (marker of fruit/vegetable intake) showed no difference between groups.
Drinking Concord grape juice daily for 9 weeks increased serum vitamin C, improved antioxidant measures, and increased certain immune cell measures versus placebo.
Drinking Concord grape juice daily for 9 weeks increased serum vitamin C, improved antioxidant measures, and increased certain immune cell measures versus placebo.
A double-blind RCT of a micronutrient combination including vitamin D3 modestly improved common cold symptom scores and reduced the decline in 25(OH)D3 vs placebo.
A double-blind RCT of a micronutrient combination including vitamin D3 modestly improved common cold symptom scores and reduced the decline in 25(OH)D3 vs placebo.
Giving low consumers ~480 g/day fruit/veg + up to 300 ml juice for 12 weeks raised blood vitamin C and other nutrients but did not change measures of plasma antioxidant capacity or vascular risk markers.
An 8-week double-blind RCT of a multivitamin/multimineral/phytonutrient product increased vitamin C and folate status and reduced homocysteine in adults with low fruit/veg intake.
A 12-week water-soluble vitamin supplement improved some vitamin biomarkers, increased weight, and lowered homocysteine in elderly female residents; plasma vitamin C rose in both groups.
In a large 7.3‑year randomized trial (n=3411), garlic increased serum folate and a vitamin+selenium supplement increased glutathione, but neither intervention changed serum vitamin B12 or homocysteine.
An 8-week double-blind RCT of a multivitamin/multimineral/phytonutrient product increased vitamin C and folate status and reduced homocysteine in adults with low fruit/veg intake.
Feasibility RCT comparing high‑flow heated humidified air (rhinothermy) versus low‑dose vitamin C (250 mg/day) as control; rhinothermy reduced cold symptom scores faster than the vitamin C control.
Feasibility RCT comparing high‑flow heated humidified air (rhinothermy) versus low‑dose vitamin C (250 mg/day) as control; rhinothermy reduced cold symptom scores faster than the vitamin C control.
Double-masked, placebo-controlled 100-day trial in 100 anemic schoolchildren comparing a multi‑fortified juice (including zinc) vs non‑fortified juice; supervised administration and deworming were done.
Double-masked, placebo-controlled 100-day trial in 100 anemic schoolchildren comparing a multi‑fortified juice (including zinc) vs non‑fortified juice; supervised administration and deworming were done.
In a large online randomized experiment, a "100% Vitamin C" claim on fruit drinks increased parents' selection of fruit drinks over 100% juice or water.
In 75 men with CAD, vitamin C co‑infusion increased baseline forearm blood flow and acetylcholine‑stimulated responses in patients with elevated CRP, indicating improved NO bioavailability.
In 75 men with CAD, vitamin C co‑infusion increased baseline forearm blood flow and acetylcholine‑stimulated responses in patients with elevated CRP, indicating improved NO bioavailability.
A 14-day antioxidant supplement including vitamin C largely restored retinal blood-flow responses blunted by low-dose endotoxin in healthy volunteers.
A 14-day antioxidant supplement including vitamin C largely restored retinal blood-flow responses blunted by low-dose endotoxin in healthy volunteers.
A 14-day antioxidant supplement including vitamin C largely restored retinal blood-flow responses blunted by low-dose endotoxin in healthy volunteers.
Multivitamin/mineral supplements given to women undergoing IVF were associated with decreased oxidative stress markers and higher antioxidant vitamin levels in serum and follicular fluid.
Children treated with a PPI or with low-dose vitamin C both showed reduced adenoid size, with no difference between groups.
Increasing fruit and vegetable intake after surgery reduced CRP more than usual diet, with a correlation between vitamin C intake and CRP reduction.
Following the DASH diet (which raised serum vitamin C) reduced some oxidative stress markers and improved migraine scores versus usual diet.
In healthy men, coinfusion of vitamin C acutely restored endothelial (acetylcholine) responses that were impaired by continuous nitroglycerin.
In healthy men, coinfusion of vitamin C acutely restored endothelial (acetylcholine) responses that were impaired by continuous nitroglycerin.
Critically ill septic patients receiving an enteral supplement (including vitamin C) had faster improvement in organ dysfunction and serum vitamin C rose to normal range by day 3.
Non-hospitalized adults with COVID-19/covid-like illness received melatonin, zinc and multivitamins (including vitamin D) or placebo; the supplement arm had faster symptom resolution by days 5 and 10.
Non-hospitalized adults with COVID-19/covid-like illness received melatonin, zinc and multivitamins (including vitamin D) or placebo; the supplement arm had faster symptom resolution by days 5 and 10.
12-week triple-blind randomized placebo-controlled trial in women showed that a drinkable supplement containing collagen peptides and dermonutrients improved dermal collagen structure and subjective skin measures without adverse events.
12-week triple-blind randomized placebo-controlled trial in women showed that a drinkable supplement containing collagen peptides and dermonutrients improved dermal collagen structure and subjective skin measures without adverse events.
A multi-ingredient CAM (including vitamin D) reduced urinary frequency, nocturia, and urge incontinence and was reported more effective and better tolerated than solifenacin in this small RCT.
A multi-ingredient CAM (including vitamin D) reduced urinary frequency, nocturia, and urge incontinence and was reported more effective and better tolerated than solifenacin in this small RCT.
A multi-ingredient CAM (including vitamin D) reduced urinary frequency, nocturia, and urge incontinence and was reported more effective and better tolerated than solifenacin in this small RCT.
Giving HIV-infected mothers multivitamins (including B12) during pregnancy and postpartum improved their children's weight at 24 months.
Giving HIV-infected mothers multivitamins (including B12) during pregnancy and postpartum improved their children's weight at 24 months.
A 4-week polyphenol beverage that contained vitamin C did not improve vascular function but was associated with an increase in IL-6 compared with placebo.
In this prospective cohort of male smokers, higher dietary vitamin C intake was associated with lower risk of gastric noncardia cancer.
In dental students under exam stress, a daily micronutrient supplement including vitamin C modestly raised plasma vitamin C and showed small non-significant improvements in inflammatory and antioxidant markers.
Randomized placebo‑controlled 12‑week trial in 72 women: daily drinkable collagen peptides + dermonutrients improved objective measures of skin appearance versus placebo.
Randomized placebo‑controlled 12‑week trial in 72 women: daily drinkable collagen peptides + dermonutrients improved objective measures of skin appearance versus placebo.
Randomized placebo‑controlled 12‑week trial in 72 women: daily drinkable collagen peptides + dermonutrients improved objective measures of skin appearance versus placebo.
Osteopenic postmenopausal women receiving antioxidant supplement mix (including vitamin C) plus calcium/vitamin D had a small but borderline-significant better heel BMD after 12 months versus calcium/vitamin D alone.
In patients on isosorbide dinitrate, adding vitamin C (ISD+vitamin C) reduced occurrence of nitrate tolerance and improved endothelial-dependent vasodilation and eNOS expression compared with ISD alone over a 10-day course.
In patients on isosorbide dinitrate, adding vitamin C (ISD+vitamin C) reduced occurrence of nitrate tolerance and improved endothelial-dependent vasodilation and eNOS expression compared with ISD alone over a 10-day course.
In patients on isosorbide dinitrate, adding vitamin C (ISD+vitamin C) reduced occurrence of nitrate tolerance and improved endothelial-dependent vasodilation and eNOS expression compared with ISD alone over a 10-day course.
In institutionalized elderly, daily vitamin supplementation (including 120 mg vitamin C) raised plasma vitamin levels (including vitamin C) and some antioxidant enzyme activity over 6–12 months, with limited effects on most immune markers.
In institutionalized elderly, daily vitamin supplementation (including 120 mg vitamin C) raised plasma vitamin levels (including vitamin C) and some antioxidant enzyme activity over 6–12 months, with limited effects on most immune markers.
Daily fortified yogurt containing HMB, 1000 IU vitamin D, and vitamin C improved handgrip strength, gait speed, vitamin D and IGF-1 levels, and reduced inflammation markers versus control in sarcopenic older adults.
A school nutrition intervention increased fruit and vegetable intake by 47% in 7-9-year-olds and produced a borderline increase in vitamin C intake.
In this 13-year cohort study, higher vitamin C intake was positively associated with verbal memory performance but study design is observational.
A 3-week fruit/vegetable concentrate raised blood vitamin C and some antioxidants but did not change markers of oxidative damage in male smokers.
In pregnant women with obesity, adding a supplement (includes 90 mg vitamin C plus other nutrients) raised some micronutrients but did not change vitamin C levels or markers of inflammation/oxidative stress.
In athletes, adding an antioxidant mixture (includes 60 mg vitamin C) to n-3 supplementation reduced markers of exercise-induced lipid peroxidation but did not prevent increased resting oxidative stress from n-3 alone.
In athletes, adding an antioxidant mixture (includes 60 mg vitamin C) to n-3 supplementation reduced markers of exercise-induced lipid peroxidation but did not prevent increased resting oxidative stress from n-3 alone.
A single 30-s bedtime rinse with a chlorhexidine + vitamin C mouthwash reduced some volatile sulfur compounds in morning breath versus placebo, though organoleptic scores did not differ.
A single 30-s bedtime rinse with a chlorhexidine + vitamin C mouthwash reduced some volatile sulfur compounds in morning breath versus placebo, though organoleptic scores did not differ.
A single 30-s bedtime rinse with a chlorhexidine + vitamin C mouthwash reduced some volatile sulfur compounds in morning breath versus placebo, though organoleptic scores did not differ.
A 12-week randomized trial of a multi-ingredient flavonoid chewable (which included vitamin C) increased urine total phenolics and certain gut-derived phenolic metabolites but did not change common inflammation or oxidative stress markers.
A 12-week randomized trial of a multi-ingredient flavonoid chewable (which included vitamin C) increased urine total phenolics and certain gut-derived phenolic metabolites but did not change common inflammation or oxidative stress markers.
A 12-week randomized trial of a multi-ingredient flavonoid chewable (which included vitamin C) increased urine total phenolics and certain gut-derived phenolic metabolites but did not change common inflammation or oxidative stress markers.
In this observational analysis, higher premorbid vitamin C intake was not linked to tumor ER/PR status or size but was associated with a lower risk of dying from breast cancer.
In this observational analysis, higher premorbid vitamin C intake was not linked to tumor ER/PR status or size but was associated with a lower risk of dying from breast cancer.
In healthy adults placed on a low-ascorbate diet, 2-week antioxidant supplementation including 250 mg vitamin C reduced ozone-induced declines in lung function but did not affect airway inflammatory markers.
In healthy adults placed on a low-ascorbate diet, 2-week antioxidant supplementation including 250 mg vitamin C reduced ozone-induced declines in lung function but did not affect airway inflammatory markers.
In healthy adults placed on a low-ascorbate diet, 2-week antioxidant supplementation including 250 mg vitamin C reduced ozone-induced declines in lung function but did not affect airway inflammatory markers.
Cyclists taking a daily antioxidant supplement (including vitamin C) showed protection of lung function against ozone exposure compared with non-supplemented cyclists.
Cyclists taking a daily antioxidant supplement (including vitamin C) showed protection of lung function against ozone exposure compared with non-supplemented cyclists.
Cyclists taking a daily antioxidant supplement (including vitamin C) showed protection of lung function against ozone exposure compared with non-supplemented cyclists.
People with symptomatic eye floaters who took a 6-month micronutrient supplement (including vitamin C) reported less discomfort and had smaller measured floater areas than before treatment.
People with symptomatic eye floaters who took a 6-month micronutrient supplement (including vitamin C) reported less discomfort and had smaller measured floater areas than before treatment.
People with symptomatic eye floaters who took a 6-month micronutrient supplement (including vitamin C) reported less discomfort and had smaller measured floater areas than before treatment.
Physically active men who practiced yoga for 3 months had improvements in antioxidant markers (including higher vitamin C) and some metabolic measures versus controls.
Physically active men who practiced yoga for 3 months had improvements in antioxidant markers (including higher vitamin C) and some metabolic measures versus controls.
A cluster RCT of an agriculture-plus-nutrition program increased the probability that preschool children met recommended intakes of several micronutrients, including vitamin C.
A cluster RCT of an agriculture-plus-nutrition program increased the probability that preschool children met recommended intakes of several micronutrients, including vitamin C.
A cluster RCT of an agriculture-plus-nutrition program increased the probability that preschool children met recommended intakes of several micronutrients, including vitamin C.
A combined nutraceutical containing bergamot extract and phytosterols improved triglycerides, LDL-C, and insulin resistance markers versus placebo in overweight dyslipidemic subjects.
In women, interpersonal stressors were associated with higher ghrelin, lower leptin, and small/marginal increases in several dietary components including vitamin C intake.
Long-term low-dose antioxidant supplementation (including 120 mg vitamin C) did not affect vascular disease but lowered total cancer incidence in men.
Long-term low-dose antioxidant supplementation (including 120 mg vitamin C) did not affect vascular disease but lowered total cancer incidence in men.
A combined nutraceutical containing bergamot extract and phytosterols improved triglycerides, LDL-C, and insulin resistance markers versus placebo in overweight dyslipidemic subjects.
Subgroup analysis of an RCT (MVP Trial) where one arm received multivitamins (including vitamin C 500 mg) ± probucol; outcomes were lumen loss and restenosis at 6 months.
Subgroup analysis of an RCT (MVP Trial) where one arm received multivitamins (including vitamin C 500 mg) ± probucol; outcomes were lumen loss and restenosis at 6 months.
In healthy volunteers, IV vitamin C (2 g) given with nitroglycerin removed nitroglycerin's protective effect on blood-vessel dilation after ischemia-reperfusion.
A 5-week multi-ingredient supplement (including vitamin C) modestly increased adiponectin and produced subtle omics-signals of reduced inflammation and oxidative stress in overweight men; CRP unchanged.
A 5-week multi-ingredient supplement (including vitamin C) modestly increased adiponectin and produced subtle omics-signals of reduced inflammation and oxidative stress in overweight men; CRP unchanged.
In low-income adults, fruit-and-vegetable vouchers increased short-term consumption but did not change blood vitamin C levels at 3 months.
In 7–11-year-old schoolchildren, one year of a multiple-micronutrient food supplement (including B12) improved hemoglobin/red cell indices and several memory and attention test scores compared with controls.
In 7–11-year-old schoolchildren, one year of a multiple-micronutrient food supplement (including B12) improved hemoglobin/red cell indices and several memory and attention test scores compared with controls.
Randomized trial in children 1–3 y: milk fortified with multiple micronutrients (including vitamin C) reduced diarrhoea, lower respiratory infections and days with severe illness.
Randomized trial in children 1–3 y: milk fortified with multiple micronutrients (including vitamin C) reduced diarrhoea, lower respiratory infections and days with severe illness.
Randomized trial in children 1–3 y: milk fortified with multiple micronutrients (including vitamin C) reduced diarrhoea, lower respiratory infections and days with severe illness.
Two-month Mediterranean-style diet (which increased dietary vitamin C intake) showed within-group decreases in some inflammation markers but no significant between-group changes for most adhesion molecules.
Two-month Mediterranean-style diet (which increased dietary vitamin C intake) showed within-group decreases in some inflammation markers but no significant between-group changes for most adhesion molecules.
Large randomized placebo-controlled trial of combined antioxidant supplements (including 120 mg vitamin C) found higher skin cancer incidence in women assigned to antioxidants, with no effect in men.
Large randomized placebo-controlled trial of combined antioxidant supplements (including 120 mg vitamin C) found higher skin cancer incidence in women assigned to antioxidants, with no effect in men.
Large randomized placebo-controlled trial of combined antioxidant supplements (including 120 mg vitamin C) found higher skin cancer incidence in women assigned to antioxidants, with no effect in men.
Cross-sectional analysis relating dietary vitamins (including vitamin C) to early AMD signs; higher vitamin A (not vitamin C) intake associated with larger drusen in certain genotypes.
Cross-sectional analysis relating dietary vitamins (including vitamin C) to early AMD signs; higher vitamin A (not vitamin C) intake associated with larger drusen in certain genotypes.
Large randomized, blinded trial gave IV antioxidants (3 g vitamin C + NAC) perioperatively and found no reduction in postoperative myocardial injury compared with placebo.
Patients with IgA nephropathy had more oxidative damage and lower antioxidant levels including vitamin C than healthy volunteers.
Randomized double-blind trial in pregnant women: micronutrient supplement raised maternal vitamin levels, was associated with 10% higher birth weights and fewer low-birth-weight infants; maternal plasma zinc correlated with newborn height.
Randomized double-blind trial in pregnant women: micronutrient supplement raised maternal vitamin levels, was associated with 10% higher birth weights and fewer low-birth-weight infants; maternal plasma zinc correlated with newborn height.
A multi-antioxidant supplement (including 500 mg vitamin C) prevented the rise in plasma lipid hydroperoxides seen in placebo but urine oxidative markers rose in both groups, showing mixed effects.
A multi-antioxidant supplement (including 500 mg vitamin C) prevented the rise in plasma lipid hydroperoxides seen in placebo but urine oxidative markers rose in both groups, showing mixed effects.
A multi-antioxidant supplement (including 500 mg vitamin C) prevented the rise in plasma lipid hydroperoxides seen in placebo but urine oxidative markers rose in both groups, showing mixed effects.
GTN and PETN prevented IR-induced endothelial dysfunction; ISMN did not; vitamin C blocked GTN protection but did not alter PETN's protective effect.
GTN and PETN prevented IR-induced endothelial dysfunction; ISMN did not; vitamin C blocked GTN protection but did not alter PETN's protective effect.
A 4-week anti-inflammatory diet (which included vitamin C among many components) reduced gum bleeding in people with gingivitis.
A 4-week anti-inflammatory diet (which included vitamin C among many components) reduced gum bleeding in people with gingivitis.
In elderly patients with chronic heart failure, long-term high-dose multiple micronutrient supplementation (including vitamin D) improved left ventricular volumes, increased LVEF and improved quality-of-life versus placebo.
In elderly patients with chronic heart failure, long-term high-dose multiple micronutrient supplementation (including vitamin D) improved left ventricular volumes, increased LVEF and improved quality-of-life versus placebo.
Following the DASH diet (which raised serum vitamin C) reduced some oxidative stress markers and improved migraine scores versus usual diet.
Following the DASH diet (which raised serum vitamin C) reduced some oxidative stress markers and improved migraine scores versus usual diet.
Randomized crossover field study (75 analyzed); night aircraft noise impaired endothelial function and raised adrenaline; an acute oral Vitamin C challenge (2 g) in a small subgroup (n=5) improved flow‑mediated dilation.
Randomized crossover field study (75 analyzed); night aircraft noise impaired endothelial function and raised adrenaline; an acute oral Vitamin C challenge (2 g) in a small subgroup (n=5) improved flow‑mediated dilation.
Randomized crossover field study (75 analyzed); night aircraft noise impaired endothelial function and raised adrenaline; an acute oral Vitamin C challenge (2 g) in a small subgroup (n=5) improved flow‑mediated dilation.
Randomized trial found a high-polyphenol diet increased vitamin C biomarkers and improved endothelium-dependent vasodilation in hypertensive participants.
Oral nutritional supplements plus dietary counseling increased energy and micronutrient intakes (including calcium), and improved appetite versus counseling alone in picky-eating children over 90 days.
Oral nutritional supplements plus dietary counseling increased energy and micronutrient intakes (including calcium), and improved appetite versus counseling alone in picky-eating children over 90 days.
Daily baobab fruit pulp (rich in vitamin C) given with a school meal for 83 days produced a small increase in hemoglobin and smaller declines in ferritin versus control, but differences were not statistically significant.
Daily baobab fruit pulp (rich in vitamin C) given with a school meal for 83 days produced a small increase in hemoglobin and smaller declines in ferritin versus control, but differences were not statistically significant.
6-month randomized weight-loss program (partial meal replacements + exercise) in older obese adults improved diet quality and increased intake of key micronutrients despite reduced calories.
In adolescents with poorly controlled type 1 diabetes, improved glycemic control and 3–6 months of antioxidant supplementation (including vitamin C) did not restore erythrocyte glutathione or reduce markers of oxidative stress.
A mobile-technology education program (MyPinkMom) for anemic pregnant women increased dietary vitamin C intake substantially and improved hemoglobin versus routine counseling.
Type 2 diabetic patients given micronutrient formulas (one including B-vitamins) reported reduced neuropathy symptom scores, but objective measures did not differ between groups.
Type 2 diabetic patients given micronutrient formulas (one including B-vitamins) reported reduced neuropathy symptom scores, but objective measures did not differ between groups.
Double-blind RCT of a multivitamin/mineral vs placebo in older adults on certain medications; MVMS increased folate and vitamin C status but did not significantly change serum calcium.
In post-polypectomy patients, long-term daily antioxidant supplementation that included zinc (30 mg) reduced adenoma recurrence over follow-up (~39% reduced risk; adjusted HR=0.61, 95% CI 0.41–0.92).
Randomized trial found a high-polyphenol diet increased vitamin C biomarkers and improved endothelium-dependent vasodilation in hypertensive participants.
A revised parenteral nutrition formula restored vitamin C and other vitamin levels to normal ranges after gastrointestinal surgery.
A revised parenteral nutrition formula restored vitamin C and other vitamin levels to normal ranges after gastrointestinal surgery.
Antioxidant supplementation (1000 mg vitamin C + vitamin E) reduced exercise-induced leukocyte DNA damage in women but not in men after a 50 km ultramarathon.
A high-dose antioxidant combination including 250 mg vitamin C showed no benefit in reducing major vascular events in PAD patients over 2 years.
An acute antioxidant cocktail including vitamin C improved vascular function measures in COPD patients compared with placebo.
In smokers with hyperlipidaemia, antioxidant supplementation including 150 mg vitamin C had no effect on measured endothelial cell markers over 6 weeks.
Women with cervical cancer received an antioxidant mix (including vitamin C) during radiotherapy; supplementation reduced protein oxidative stress and improved quality of life.
Women with cervical cancer received an antioxidant mix (including vitamin C) during radiotherapy; supplementation reduced protein oxidative stress and improved quality of life.
Preschool children consumed milk fortified with multiple micronutrients (including vitamin C) for 1 year; fortified milk improved growth and iron status and reduced anemia.
Preschool children consumed milk fortified with multiple micronutrients (including vitamin C) for 1 year; fortified milk improved growth and iron status and reduced anemia.
Adults with metabolic syndrome counseled on DASH diet plus low-sodium vegetable juice (a source of vitamin C) increased vitamin C intake and experienced modestly greater weight loss; oxidative stress markers did not change.
Crossover RCT increasing potassium intake from fruit/veg or supplements in early hypertensives; plasma vitamin C was measured and remained unchanged and blood pressure did not improve.
A large randomized trial found that low-dose antioxidant supplementation (including vitamin C) did not reduce 6.5-year risk of high blood pressure; baseline beta-carotene in men and higher vitamin C in women showed observational associations with lower risk.
A large randomized trial found that low-dose antioxidant supplementation (including vitamin C) did not reduce 6.5-year risk of high blood pressure; baseline beta-carotene in men and higher vitamin C in women showed observational associations with lower risk.
A large randomized trial found that low-dose antioxidant supplementation (including vitamin C) did not reduce 6.5-year risk of high blood pressure; baseline beta-carotene in men and higher vitamin C in women showed observational associations with lower risk.
A case-control study found no association between circulating vitamin C and risk of benign breast fibroadenomas.
A case-control study found no association between circulating vitamin C and risk of benign breast fibroadenomas.
In a large randomized trial, high-dose zinc supplementation increased hospital admissions for genitourinary problems, including UTIs and urinary retention/stone events.
In a large randomized trial, high-dose zinc supplementation increased hospital admissions for genitourinary problems, including UTIs and urinary retention/stone events.
A 10-week mixed flavonoid–fish oil supplement (which included 250 mg vitamin C/day) upregulated antiviral/interferon-related gene expression but did not change standard inflammatory or oxidative-stress biomarkers.
A 10-week mixed flavonoid–fish oil supplement (which included 250 mg vitamin C/day) upregulated antiviral/interferon-related gene expression but did not change standard inflammatory or oxidative-stress biomarkers.
A 10-week mixed flavonoid–fish oil supplement (which included 250 mg vitamin C/day) upregulated antiviral/interferon-related gene expression but did not change standard inflammatory or oxidative-stress biomarkers.
A 10-week mixed flavonoid–fish oil supplement (which included 250 mg vitamin C/day) upregulated antiviral/interferon-related gene expression but did not change standard inflammatory or oxidative-stress biomarkers.
Daily antioxidant tablets (including vitamin C) raised blood antioxidant levels but did not reduce pain or improve quality of life compared with placebo in chronic pancreatitis patients.
Daily antioxidant tablets (including vitamin C) raised blood antioxidant levels but did not reduce pain or improve quality of life compared with placebo in chronic pancreatitis patients.
Daily antioxidant tablets (including vitamin C) raised blood antioxidant levels but did not reduce pain or improve quality of life compared with placebo in chronic pancreatitis patients.
Ten days of steamed broccoli (which contains vitamin C among other antioxidants) reduced oxidized DNA lesions and increased resistance to oxidative DNA damage in young smokers.
Ten days of steamed broccoli (which contains vitamin C among other antioxidants) reduced oxidized DNA lesions and increased resistance to oxidative DNA damage in young smokers.
Ten days of steamed broccoli (which contains vitamin C among other antioxidants) reduced oxidized DNA lesions and increased resistance to oxidative DNA damage in young smokers.
A 4-month high-antioxidant diet (designed to raise vitamins A, C and E) increased plasma and leukocyte vitamin C, boosted antioxidant enzyme activities, and lowered lipid oxidative markers in women with endometriosis.
Randomized double-blind trial of Macuprev (multi-ingredient supplement including vitamin D3 800 IU) vs placebo in 30 patients with intermediate AMD (28 completed): after 6 months the active supplement increased central mfERG amplitudes (R1 and R2) without OCT structural changes.
Randomized double-blind trial of Macuprev (multi-ingredient supplement including vitamin D3 800 IU) vs placebo in 30 patients with intermediate AMD (28 completed): after 6 months the active supplement increased central mfERG amplitudes (R1 and R2) without OCT structural changes.
Randomized double-blind trial of Macuprev (multi-ingredient supplement including vitamin D3 800 IU) vs placebo in 30 patients with intermediate AMD (28 completed): after 6 months the active supplement increased central mfERG amplitudes (R1 and R2) without OCT structural changes.
Kindergarten children received Sprinkles (contain vitamin C among other micronutrients) daily or weekly for 13 weeks; high consumption and no evidence of iron overload were observed.
A large randomized trial of a multivitamin/mineral supplement (including zinc) vs placebo in men showed no significant overall reduction in prostate cancer, but a significant reduction in men with normal baseline PSA; PSA and IGF levels were unchanged.
A large randomized trial of a multivitamin/mineral supplement (including zinc) vs placebo in men showed no significant overall reduction in prostate cancer, but a significant reduction in men with normal baseline PSA; PSA and IGF levels were unchanged.
Daily antioxidant supplementation (including high-dose vitamin C) attenuated ozone-associated declines in lung function among exposed workers compared with placebo.
Daily antioxidant supplementation (including high-dose vitamin C) attenuated ozone-associated declines in lung function among exposed workers compared with placebo.
Daily antioxidant supplementation (including high-dose vitamin C) attenuated ozone-associated declines in lung function among exposed workers compared with placebo.
In HIV-infected breastfeeding women, a multivitamin (which included vitamin C) had no effect on HIV levels in breast milk, whereas β-carotene/preformed vitamin A increased detectable viral load.
In HIV-infected breastfeeding women, a multivitamin (which included vitamin C) had no effect on HIV levels in breast milk, whereas β-carotene/preformed vitamin A increased detectable viral load.
Acute vitamin C infusion improved brachial artery flow-mediated dilation in older men with low testosterone but had no effect in young men or older men with higher testosterone.
Acute vitamin C infusion improved brachial artery flow-mediated dilation in older men with low testosterone but had no effect in young men or older men with higher testosterone.
Children given improved gruel with or without a multi-micronutrient mix (including iodine) both showed Hb increases; the micronutrient mix added no significant benefit.
In placentas from type 1 diabetic pregnancies, maternal vitamin C+E supplementation did not alter nitrotyrosine staining or activities of p38-MAPKα, ERK, or JNK.
In placentas from type 1 diabetic pregnancies, maternal vitamin C+E supplementation did not alter nitrotyrosine staining or activities of p38-MAPKα, ERK, or JNK.
Increasing consumption of citrus fruit/juice (rich in vitamin C) after meals improved serum ferritin in iron-depleted preschool children over three months.
A 1-year dietary consultation aimed to reduce salt and increase vitamin C/carotene; urinary DNA-damage marker (εdA) tended to decrease in the intervention group but changes were not statistically significant.
A 1-year dietary consultation aimed to reduce salt and increase vitamin C/carotene; urinary DNA-damage marker (εdA) tended to decrease in the intervention group but changes were not statistically significant.
Perioperative antioxidant treatment (vitamin C plus other antioxidants) better preserved pulmonary endothelium-dependent vasodilation after cardiopulmonary bypass than placebo.
Perioperative antioxidant treatment (vitamin C plus other antioxidants) better preserved pulmonary endothelium-dependent vasodilation after cardiopulmonary bypass than placebo.
In patients with mild–moderate ulcerative colitis, a multi-ingredient supplement (including vitamin C) did not change disease activity more than placebo but allowed a greater reduction in prednisone use over 6 months.
In patients with mild–moderate ulcerative colitis, a multi-ingredient supplement (including vitamin C) did not change disease activity more than placebo but allowed a greater reduction in prednisone use over 6 months.
Randomized double-blind trial of a multi-nutrient supplement (including collagen type II) vs placebo for lumbar osteochondrosis; no differences in patient-reported outcomes, but supplement group showed significant increases in 3D-measured intervertebral disc (IVD) volumes.
Randomized double-blind trial of a multi-nutrient supplement (including collagen type II) vs placebo for lumbar osteochondrosis; no differences in patient-reported outcomes, but supplement group showed significant increases in 3D-measured intervertebral disc (IVD) volumes.
Eating two kiwifruit daily increased vitamin C intake and lowered systolic blood pressure by ~2.7 mmHg over 7 weeks, without changing fasting insulin or other metabolic markers.
Daily consumption of a dairy product enriched with calcium, vitamin D and other bone‑supporting nutrients for 24 weeks improved bone mass and bone turnover markers and mitigated BMD loss in menopausal women at risk of osteoporosis.
Daily consumption of a dairy product enriched with calcium, vitamin D and other bone‑supporting nutrients for 24 weeks improved bone mass and bone turnover markers and mitigated BMD loss in menopausal women at risk of osteoporosis.
Daily consumption of a dairy product enriched with calcium, vitamin D and other bone‑supporting nutrients for 24 weeks improved bone mass and bone turnover markers and mitigated BMD loss in menopausal women at risk of osteoporosis.
Daily consumption of a dairy product enriched with calcium, vitamin D and other bone‑supporting nutrients for 24 weeks improved bone mass and bone turnover markers and mitigated BMD loss in menopausal women at risk of osteoporosis.
Daily antioxidant (including 50 mg vitamin C) and/or folinic acid given in infancy produced no measurable benefit in development or language at 18 months.
Daily antioxidant (including 50 mg vitamin C) and/or folinic acid given in infancy produced no measurable benefit in development or language at 18 months.
Daily antioxidant (including 50 mg vitamin C) and/or folinic acid given in infancy produced no measurable benefit in development or language at 18 months.
Home fortification micronutrient powder (contains vitamin C among others) was at least as effective as iron–folic acid tablets in maintaining hemoglobin during pregnancy, though adherence was lower.
In healthy young adults a single antioxidant cocktail (including vitamin C) taken before a high-sodium meal did not change endothelial function or arterial stiffness compared with placebo.
Five-day IV antioxidant regimen (including high-dose vitamin C) did not improve early organ dysfunction (SOFA) or AKI overall, but reduced CRP (blunted inflammation) and showed some shorter hospital stay in trauma subgroup.
Five-day IV antioxidant regimen (including high-dose vitamin C) did not improve early organ dysfunction (SOFA) or AKI overall, but reduced CRP (blunted inflammation) and showed some shorter hospital stay in trauma subgroup.
Adults with mild-to-moderate prolonged fatigue who took a pomegranate extract plus water-soluble vitamins (including 200 mg vitamin C) for 2 months reported reduced fatigue severity versus placebo; biomarkers showed no clear treatment-specific changes.
Adults with mild-to-moderate prolonged fatigue who took a pomegranate extract plus water-soluble vitamins (including 200 mg vitamin C) for 2 months reported reduced fatigue severity versus placebo; biomarkers showed no clear treatment-specific changes.
Adults with mild-to-moderate prolonged fatigue who took a pomegranate extract plus water-soluble vitamins (including 200 mg vitamin C) for 2 months reported reduced fatigue severity versus placebo; biomarkers showed no clear treatment-specific changes.
Analysis of factors linked to blood vitamin E levels in postmenopausal women; supplemental vitamin C was associated with higher alpha- and lower gamma-tocopherol.
Analysis of factors linked to blood vitamin E levels in postmenopausal women; supplemental vitamin C was associated with higher alpha- and lower gamma-tocopherol.
In hemodialysis patients, an antioxidant cocktail that included vitamin B12 did not change markers of oxidative stress or inflammation over 8 weeks.
In hemodialysis patients, an antioxidant cocktail that included vitamin B12 did not change markers of oxidative stress or inflammation over 8 weeks.
Large prospective cohort of male smokers found no link between dietary or serum antioxidant vitamins (including vitamin C) and colorectal cancer risk.
Randomized 8-week trial: adding fruit or nuts raised serum vitamin C in both groups; no change in hepatic fat; basal metabolic rate increased in the nut group.
Randomized 8-week trial: adding fruit or nuts raised serum vitamin C in both groups; no change in hepatic fat; basal metabolic rate increased in the nut group.
In HIV-infected pregnant women, multivitamin supplements (including vitamin C) at single versus multiple RDA doses produced similar pregnancy outcomes.
In HIV-infected pregnant women, multivitamin supplements (including vitamin C) at single versus multiple RDA doses produced similar pregnancy outcomes.
In children undergoing outpatient pin removal, acetaminophen or ibuprofen did not reduce pain compared with placebo (vitamin C used as placebo).
In patients with type 2 diabetes, a calorie-restricted vegetarian diet (± exercise) improved insulin sensitivity, reduced visceral fat, and increased plasma vitamin C versus a conventional diet.
In patients with type 2 diabetes, a calorie-restricted vegetarian diet (± exercise) improved insulin sensitivity, reduced visceral fat, and increased plasma vitamin C versus a conventional diet.
The FAVVA brief index correlates moderately-strongly with total daily vegetable/fruit intake and with multiple nutrient intakes (including calcium) and plasma carotenoids.
The FAVVA brief index correlates moderately-strongly with total daily vegetable/fruit intake and with multiple nutrient intakes (including calcium) and plasma carotenoids.
Hemodialysis patients received a multi-nutrient drink (includes 30 µg B12) or placebo for 12 weeks; the supplement improved some objective autonomic and immune markers but not subjective fatigue versus placebo.
Hemodialysis patients received a multi-nutrient drink (includes 30 µg B12) or placebo for 12 weeks; the supplement improved some objective autonomic and immune markers but not subjective fatigue versus placebo.
Hemodialysis patients received a multi-nutrient drink (includes 30 µg B12) or placebo for 12 weeks; the supplement improved some objective autonomic and immune markers but not subjective fatigue versus placebo.
In women, interpersonal stressors were associated with higher ghrelin, lower leptin, and small/marginal increases in several dietary components including vitamin C intake.
Maternal multiple micronutrient supplements (which included 10 µg vitamin D) did not reduce overall fetal loss or early infant mortality; effects of vitamin D alone were not separable.
Maternal multiple micronutrient supplements (which included 10 µg vitamin D) did not reduce overall fetal loss or early infant mortality; effects of vitamin D alone were not separable.
Maternal multiple micronutrient supplements (which included 10 µg vitamin D) did not reduce overall fetal loss or early infant mortality; effects of vitamin D alone were not separable.
New parenteral nutrition with multivitamins increased blood vitamin C and was safely tolerated in healthy volunteers.
New parenteral nutrition with multivitamins increased blood vitamin C and was safely tolerated in healthy volunteers.
Randomized trial comparing GUMLi formula vs cows' milk in toddlers; reports nutrient intake differences including higher vitamin D intake in the GUMLi group.
Randomized trial comparing GUMLi formula vs cows' milk in toddlers; reports nutrient intake differences including higher vitamin D intake in the GUMLi group.
In a large 7.3‑year randomized trial (n=3411), garlic increased serum folate and a vitamin+selenium supplement increased glutathione, but neither intervention changed serum vitamin B12 or homocysteine.
In a large 7.3‑year randomized trial (n=3411), garlic increased serum folate and a vitamin+selenium supplement increased glutathione, but neither intervention changed serum vitamin B12 or homocysteine.
In this cohort, vitamin C intake did not modify associations between nitrate exposure and pancreatic cancer risk.
In this cohort, vitamin C intake did not modify associations between nitrate exposure and pancreatic cancer risk.
Controlled exposure to fine particulates (± ozone) increased diastolic blood pressure and, in one location, impaired endothelial function; high-dose vitamin C (2 g) pretreatment did not prevent the BP rise or endothelial impairment.
Among 867 newly diagnosed type 2 diabetes patients, adopting multiple healthy behaviors within 1 year was linked to lower cardiovascular disease risk over ~5 years (plasma vitamin C was used as a diet marker).
Among 867 newly diagnosed type 2 diabetes patients, adopting multiple healthy behaviors within 1 year was linked to lower cardiovascular disease risk over ~5 years (plasma vitamin C was used as a diet marker).
Among 867 newly diagnosed type 2 diabetes patients, adopting multiple healthy behaviors within 1 year was linked to lower cardiovascular disease risk over ~5 years (plasma vitamin C was used as a diet marker).
In 1,237 genotyped AREDS participants, response to AREDS supplement components (including vitamin C) reduced progression to late AMD across genotype groups with no significant genotype-by-treatment interaction.
Pooled post-hoc analysis of AREDS and AREDS2 cohorts (8,242 participants) found higher dietary intake of multiple nutrients, including vitamin C (top quintiles), was associated with decreased risk of progression to late AMD over ~10 years.
In 1,237 genotyped AREDS participants, response to AREDS supplement components (including vitamin C) reduced progression to late AMD across genotype groups with no significant genotype-by-treatment interaction.
In a randomized crossover trial of overweight/obese adolescents (58 completers), an anti-inflammatory supplement containing vitamin C maintained high-molecular-weight adiponectin but did not change insulin resistance overall; a subgroup (n=23) showed ≥10% improvement in HOMA-IR.
In a randomized crossover trial of overweight/obese adolescents (58 completers), an anti-inflammatory supplement containing vitamin C maintained high-molecular-weight adiponectin but did not change insulin resistance overall; a subgroup (n=23) showed ≥10% improvement in HOMA-IR.
Pilot randomized trial in 44 critically ill adults found enteral or parenteral alanyl-glutamine did not change plasma vitamin C, glutathione, markers of oxidative stress, lymphocyte subsets, gut permeability, or nitrogen balance compared to control by day 9.
In 186 generally healthy volunteers randomized to low-dose multi-antioxidant supplementation (including vitamin C) or placebo for two years, the supplemented group had a lower urinary thromboxane/prostacyclin metabolite ratio, suggesting reduced platelet activation.
In 186 generally healthy volunteers randomized to low-dose multi-antioxidant supplementation (including vitamin C) or placebo for two years, the supplemented group had a lower urinary thromboxane/prostacyclin metabolite ratio, suggesting reduced platelet activation.
A randomized, double-blind trial of a multi-ingredient antioxidant (including 500 mg vitamin C) found no improvement in semen parameters, sperm DNA fragmentation, or live-birth rates versus placebo.
A randomized, double-blind trial of a multi-ingredient antioxidant (including 500 mg vitamin C) found no improvement in semen parameters, sperm DNA fragmentation, or live-birth rates versus placebo.
A randomized, double-blind trial of a multi-ingredient antioxidant (including 500 mg vitamin C) found no improvement in semen parameters, sperm DNA fragmentation, or live-birth rates versus placebo.
Large multicenter prospective study found no overall reduction in hypertensive disorders of pregnancy (HDP) with antioxidants, but reported reduced HDP incidence in a predefined high-risk subgroup.
Large multicenter prospective study found no overall reduction in hypertensive disorders of pregnancy (HDP) with antioxidants, but reported reduced HDP incidence in a predefined high-risk subgroup.