Evidence-based effects and studies
Detailed analysis of research findings
Compared chlorhexidine to povidone-iodine for skin prep in upper abdominal surgery; chlorhexidine had lower SSI rates though overall difference narrowly missed conventional significance.
Large multicenter randomized trial found no difference between chlorhexidine-alcohol and povidone-iodine-alcohol for reoperation, surgical site infection, mediastinitis, or mortality after major cardiac surgery.
Povidone-iodine (alcohol or aqueous) performed similarly to chlorhexidine-alcohol for 30-day surgical site infection, complications, and hospital stay after colorectal surgery.
In lumbar fusion surgery, intraoperative povidone-iodine soaking reduced superficial tissue bacterial contamination but not deep tissues or implants; chlorhexidine soaked implants showed the greatest reduction of implant contamination; SSI rates were low and similar.
A bundle including povidone-iodine dabbing after closure plus chlorhexidine measures reduced surgical site infections compared with conventional care.
Large randomized trial comparing povidone-iodine with alcohol, chlorhexidine with alcohol, or both; no difference in surgical site infection rates among methods.
Compared two alcohol-based skin preps (one iodine-containing) for surgical site infections after colorectal surgery; iodine prep failed noninferiority.
Multicenter randomized trial comparing preoperative skin disinfection with 10% povidone-iodine versus 2% chlorhexidine in alcohol found no significant difference in surgical site infection rates.
In dirty surgical wounds, packing with oxidized regenerated cellulose reduced bacterial contamination more often than gauze soaked in iodine; no clinical surgical-site infections occurred in either group.
Compared chlorhexidine-alcohol versus iodine-alcohol for skin prep at cesarean; chlorhexidine led to fewer surgical-site infections than iodine.
Povidone-iodine irrigation did not reduce surgical site infections or hospital stay compared with normal saline after gastrectomy.
Compared chlorhexidine–alcohol to povidone–iodine for skin prep before cesarean; chlorhexidine had fewer infections but difference was not statistically significant.
Irrigating contaminated/dirty wounds with aqueous povidone‑iodine before closure did not reduce surgical site infections compared with normal saline over 30 days.
Cluster-randomized crossover trial found povidone-iodine in alcohol noninferior to chlorhexidine gluconate in alcohol for preventing surgical site infections after cardiac or abdominal surgery.
Povidone-iodine with alcohol was non-inferior to chlorhexidine-alcohol for preventing surgical site infection and was not superior to aqueous povidone-iodine.
Chlorhexidine-alcohol scrub followed by povidone-iodine paint reduced surgical site infections compared with povidone-iodine paint alone.
Compared chlorhexidine-alcohol versus iodine-alcohol for skin prep at cesarean; chlorhexidine led to fewer surgical-site infections than iodine.
Compared chlorhexidine-alcohol versus iodine-alcohol for skin prep at cesarean; chlorhexidine led to fewer surgical-site infections than iodine.
Cluster-randomized crossover trial comparing iodine-povacrylex-in-alcohol versus chlorhexidine-in-alcohol for preoperative skin antisepsis; iodine solution reduced infections in closed fractures.
Large multi-province cross-sectional survey in China assessing iodine intake sources, urinary iodine, and thyroid disease prevalence in pregnant women and adults.
Large multi-province cross-sectional survey in China assessing iodine intake sources, urinary iodine, and thyroid disease prevalence in pregnant women and adults.
Large multi-province cross-sectional survey in China assessing iodine intake sources, urinary iodine, and thyroid disease prevalence in pregnant women and adults.
Randomized trial showing that a reduced iodinated contrast protocol (≈43% lower iodine load) plus advanced reconstructions maintained or improved image quality and lesion detection in patients with impaired renal function.
Randomized trial showing that a reduced iodinated contrast protocol (≈43% lower iodine load) plus advanced reconstructions maintained or improved image quality and lesion detection in patients with impaired renal function.
Randomized trial showing that a reduced iodinated contrast protocol (≈43% lower iodine load) plus advanced reconstructions maintained or improved image quality and lesion detection in patients with impaired renal function.
Secondary analysis of parallel randomized trials found maternal mild iodine insufficiency (UIC ≤150 μg/L) in women with subclinical thyroid disease was not associated with lower offspring IQ or behavioral deficits at age 5 years.
Secondary analysis of parallel randomized trials found maternal mild iodine insufficiency (UIC ≤150 μg/L) in women with subclinical thyroid disease was not associated with lower offspring IQ or behavioral deficits at age 5 years.
Secondary analysis of parallel randomized trials found maternal mild iodine insufficiency (UIC ≤150 μg/L) in women with subclinical thyroid disease was not associated with lower offspring IQ or behavioral deficits at age 5 years.
Daily supplementation with 150 μg iodine in pregnancy improved maternal urinary iodine and urinary iodine excretion and reduced thyroglobulin compared with control, without changing maternal TSH/FT4 or neonatal TSH.
Double-blind RCT in older adults testing selenium, iodine, their combination, or placebo for 3 months; thyroid function, thyroglobulin, selenium status and urinary iodine measured.
Pregnant women randomized to two cod meals/week vs habitual diet; measured maternal urinary iodine (UIC), thyroid function, and infant development at 11 months.
Educational program improved knowledge/attitudes but did not change pregnant women's urinary iodine status.
12-week RCT in women of childbearing age: increasing cow milk intake raised urinary iodine concentration but did not change thyroid hormone or selenium measures.
A 12-week RCT in adolescents comparing fatty fish meals, meat meals, and n-3 supplements found increases in omega-3 biomarkers but no significant change in urinary iodine concentration between groups.
In overweight iodine-deficient women, daily 200 μg iodine for 6 months increased urinary iodine and reduced total cholesterol and the prevalence of hypercholesterolemia.
Higher iodine nutrition markers (e.g., serum iodine) were associated with greater risk of lateral lymph node metastasis; including iodine markers improved predictive model performance.
Daily 150 μg iodine supplementation for 24 weeks raised urinary iodine and reduced thyroglobulin levels in mildly iodine-deficient adults without changing TSH or free T4.
20-week RCT in 12–20-month-olds showing iodine-fortified milk substantially increased iodine intake and urinary iodine concentration versus non-fortified milk.
Preschool children given fatty fish 3×/week for 16 weeks had higher urinary iodine, higher n‑3 fatty acids, and higher hair mercury than children given meat.
Daily lipid-based supplement with 250 μg iodine did not raise urinary iodine concentrations in pregnant and postpartum women compared with iron–folic acid.
Very small randomized trial testing melatonin vs placebo in hyperthyroid patients receiving iodine-131; measured chromosomal damage and treatment response at 6 months.
Very small randomized trial testing melatonin vs placebo in hyperthyroid patients receiving iodine-131; measured chromosomal damage and treatment response at 6 months.
Pregnant women randomized to two cod meals/week vs habitual diet; measured maternal urinary iodine (UIC), thyroid function, and infant development at 11 months.
Pregnant women randomized to two cod meals/week vs habitual diet; measured maternal urinary iodine (UIC), thyroid function, and infant development at 11 months.
Multi-institution RCT comparing low-tube-voltage CT with lower-concentration iodinated contrast (reduced iodine load) versus conventional CTU, focusing on image quality and radiation dose.
Multi-institution RCT comparing low-tube-voltage CT with lower-concentration iodinated contrast (reduced iodine load) versus conventional CTU, focusing on image quality and radiation dose.
Multi-institution RCT comparing low-tube-voltage CT with lower-concentration iodinated contrast (reduced iodine load) versus conventional CTU, focusing on image quality and radiation dose.
Randomized trial comparing 4% chlorhexidine vs 10% iodine for preoperative vaginal preparation, measuring bacterial counts and positive cultures up to 90 minutes and postoperative infections.
Randomized trial comparing 4% chlorhexidine vs 10% iodine for preoperative vaginal preparation, measuring bacterial counts and positive cultures up to 90 minutes and postoperative infections.
Randomized trial comparing 4% chlorhexidine vs 10% iodine for preoperative vaginal preparation, measuring bacterial counts and positive cultures up to 90 minutes and postoperative infections.
Large multicenter RCT (LISA) in patients with nodular goiter comparing placebo, iodine, levothyroxine (T4), and T4+iodine over 12 months, assessing nodule and thyroid volume and urinary iodine.
Large multicenter RCT (LISA) in patients with nodular goiter comparing placebo, iodine, levothyroxine (T4), and T4+iodine over 12 months, assessing nodule and thyroid volume and urinary iodine.
Randomized comparison of two levothyroxine+iodide dose combos showed both reduced goitre size similarly with different TSH responses.
In iodine-deficient children, salt fortified with iodine plus micronized iron increased hemoglobin and iron stores and improved urinary iodine and thyroid volume over 10 months.
Postpartum iodine (50 or 250 µg) reduced thyroid size by 3 months and produced few mild transient thyroid dysfunctions.
Radioiodine reduced thyroid volume substantially; adjunct lithium prevented early radioiodine-induced hyperthyroidism.
Adding microencapsulated iron to iodized salt improved iron status and amplified the beneficial effects of iodine on thyroid size and function in goitrous, iron-deficient children.
Short-term iodine supplementation raised urinary iodine and TSH; higher supplement doses led to reduced thyroid volume at the highest doses and caused subclinical hypothyroidism at and above certain intake levels.
Low-dose iodine intake in endemic-goitre patients markedly increased urinary iodine and induced autoimmune thyroid changes in a subset (antibody rise, lymphocytic infiltration) with some developing hypo- or hyperthyroidism that mostly remitted after withdrawal.
In an iodine-deficient region, patients with metabolic syndrome had larger thyroid volumes and more nodules than matched controls.
Iodide substitution after thyroid surgery was as effective as L‑thyroxine at preventing goiter recurrence over one year.
Large multicenter RCT (LISA) in patients with nodular goiter comparing placebo, iodine, levothyroxine (T4), and T4+iodine over 12 months, assessing nodule and thyroid volume and urinary iodine.
In middle-aged and elderly patients with endemic goitre, daily iodide reduced thyroid volume over 12 months by about 16%, similar to levothyroxine, without inducing thyroid antibodies.
Low-dose iodide (0.2 mg/day) for 12 months reduced thyroid size in adults with endemic goiter but triggered reversible thyroid autoimmunity/dysfunction in a minority.
6-month randomized, double-blind 2x2 trial in children: vitamin A supplementation decreased TSH stimulation, thyroglobulin, and thyroid volume and thus reduced goiter risk in the context of mild-to-moderate iodine deficiency.
Adding 150 µg iodine to individualized L-thyroxine increased urinary iodine and produced greater (though modest) reductions in thyroid volume and stronger TSH suppression versus L-thyroxine alone.
Double-blind RCT in lactating mothers randomized to placebo, 150 μg/day, or 300 μg/day iodine; assessed maternal and infant UIC, breast-milk iodine, and infant growth over 12 months in an area with effective salt iodization.
Double-blind RCT in lactating mothers randomized to placebo, 150 μg/day, or 300 μg/day iodine; assessed maternal and infant UIC, breast-milk iodine, and infant growth over 12 months in an area with effective salt iodization.
Double-blind RCT in lactating mothers randomized to placebo, 150 μg/day, or 300 μg/day iodine; assessed maternal and infant UIC, breast-milk iodine, and infant growth over 12 months in an area with effective salt iodization.
Single-center RCT assessing whether dual-energy CT with virtual monoenergetic imaging allows halving the iodinated contrast dose for lower limb CTA while maintaining or improving image quality.
Single-center RCT assessing whether dual-energy CT with virtual monoenergetic imaging allows halving the iodinated contrast dose for lower limb CTA while maintaining or improving image quality.
Single-center RCT assessing whether dual-energy CT with virtual monoenergetic imaging allows halving the iodinated contrast dose for lower limb CTA while maintaining or improving image quality.
In chemotherapy-induced oral mucositis, the povidone-iodine–containing antiseptic regimen (AA) was associated with longer symptom duration and slower lesion remission than topical GM-CSF.
Randomized 2-year trial: Paleolithic diet reduced iodine intake and urinary iodine excretion vs standard diet.
Randomized 2-year trial: Paleolithic diet reduced iodine intake and urinary iodine excretion vs standard diet.
Randomized 2-year trial: Paleolithic diet reduced iodine intake and urinary iodine excretion vs standard diet.
Inhabitants with high cold exposure (hunters, settlement dwellers) showed signs of increased thyroid activity (higher thyroglobulin) and lower fT3 despite higher urinary iodine excretion.
Educational program improved knowledge/attitudes but did not change pregnant women's urinary iodine status.
Educational program improved knowledge/attitudes but did not change pregnant women's urinary iodine status.
Randomized trial in elective foot surgery showing both chlorhexidine and iodine skin preps markedly reduce positive skin cultures with similar clinical outcomes.
Randomized trial in elective foot surgery showing both chlorhexidine and iodine skin preps markedly reduce positive skin cultures with similar clinical outcomes.
Randomized trial in elective foot surgery showing both chlorhexidine and iodine skin preps markedly reduce positive skin cultures with similar clinical outcomes.
Fortified biscuits (including iodine) increased iodine and other micronutrient status and reduced anemia in primary schoolchildren and improved deworming effectiveness.
Double-blind randomized trial in pregnant women showed that a micronutrient-fortified beverage (including iodine) increased hemoglobin and ferritin and reduced risk of anemia and iron deficiency.
Large randomized double-blind trial: salt fortified with iodine+iron improved iron status and maintained iodine status in schoolchildren.
Large randomized double-blind trial: salt fortified with iodine+iron improved iron status and maintained iodine status in schoolchildren.
In iodine-deficient children, salt fortified with iodine plus micronized iron increased hemoglobin and iron stores and improved urinary iodine and thyroid volume over 10 months.
Large randomized double-blind trial: salt fortified with iodine+iron improved iron status and maintained iodine status in schoolchildren.
Phase 3 randomized trial comparing recombinant thyrotropin vs thyroid hormone withdrawal prior to radioactive iodine; recombinant thyrotropin was noninferior for ablation success and caused fewer hypothyroid symptoms.
Phase 3 randomized trial comparing recombinant thyrotropin vs thyroid hormone withdrawal prior to radioactive iodine; recombinant thyrotropin was noninferior for ablation success and caused fewer hypothyroid symptoms.
Phase 3 randomized trial comparing recombinant thyrotropin vs thyroid hormone withdrawal prior to radioactive iodine; recombinant thyrotropin was noninferior for ablation success and caused fewer hypothyroid symptoms.
Large field study showing widespread iodine insufficiency in pregnant women despite iodized salt policy; household salt iodine content often too low.
Pregnant women offered daily iodine had higher urinary iodine and fewer were at risk of deficiency, though >20% of supplemented women remained at risk.
Large field study showing widespread iodine insufficiency in pregnant women despite iodized salt policy; household salt iodine content often too low.
Large field study showing widespread iodine insufficiency in pregnant women despite iodized salt policy; household salt iodine content often too low.
Compared two alcohol-based skin preps (one iodine-containing) for surgical site infections after colorectal surgery; iodine prep failed noninferiority.
Povidone-iodine irrigation did not reduce surgical site infections or hospital stay compared with normal saline after gastrectomy.
Compared two alcohol-based skin preps (one iodine-containing) for surgical site infections after colorectal surgery; iodine prep failed noninferiority.
Pregnant women given MMN or small-quantity LNS containing iodine had higher urinary iodine than those given iron+folic acid; MMN/LNS groups achieved WHO-adequate median UIC.
Provision of supplements containing the WHO-recommended iodine dose (250 μg/day) did not change pregnant women's urinary iodine concentration at 36 weeks compared with iron–folic acid, likely because baseline iodine intakes were already adequate.
Pregnant women given MMN or small-quantity LNS containing iodine had higher urinary iodine than those given iron+folic acid; MMN/LNS groups achieved WHO-adequate median UIC.
Pregnant women given MMN or small-quantity LNS containing iodine had higher urinary iodine than those given iron+folic acid; MMN/LNS groups achieved WHO-adequate median UIC.
Follow-up of RCT where lactating mothers received 0, 150, or 300 µg/day iodine; children at 36 months showed higher cognitive scores in the 150 µg group versus placebo but no language/motor effects.
Follow-up of RCT where lactating mothers received 0, 150, or 300 µg/day iodine; children at 36 months showed higher cognitive scores in the 150 µg group versus placebo but no language/motor effects.
Follow-up of RCT where lactating mothers received 0, 150, or 300 µg/day iodine; children at 36 months showed higher cognitive scores in the 150 µg group versus placebo but no language/motor effects.
Short-term iodine supplementation raised urinary iodine and TSH; higher supplement doses led to reduced thyroid volume at the highest doses and caused subclinical hypothyroidism at and above certain intake levels.
20-week RCT in 12–20-month-olds showing iodine-fortified milk substantially increased iodine intake and urinary iodine concentration versus non-fortified milk.
Measured iodine in diet, water and salt of schoolchildren and found intake above recommended but below the upper limit.
Cluster-randomized cross-over trial in children showing that replacing packed lunches with New Nordic Diet school meals increased intake of fish and other foods, raising iodine intake.
Giving fortified biscuits (including iodine) to schoolchildren for 43 weeks improved iodine status, some micronutrients, and short-term memory and reduced some illness-related absences.
Giving fortified biscuits (including iodine) to schoolchildren for 43 weeks improved iodine status, some micronutrients, and short-term memory and reduced some illness-related absences.
A fortified seasoning powder served with school lunch reduced the prevalence of urinary iodine deficiency and improved zinc status in children; no clear effect on anemia prevalence.
Giving fortified biscuits (including iodine) to schoolchildren for 43 weeks improved iodine status, some micronutrients, and short-term memory and reduced some illness-related absences.
Randomized double-blind trial in women with cyclic breast pain: molecular iodine (3.0 and 6.0 mg/day) reduced breast pain and related findings versus placebo.
A daily liquid formula containing GLA, iodine (750 μg), and selenium did not reduce peak breast pain versus control but significantly reduced breast nodularity and reduced analgesic use among users.
A daily liquid formula containing GLA, iodine (750 μg), and selenium did not reduce peak breast pain versus control but significantly reduced breast nodularity and reduced analgesic use among users.
A daily liquid formula containing GLA, iodine (750 μg), and selenium did not reduce peak breast pain versus control but significantly reduced breast nodularity and reduced analgesic use among users.
Analysis of the SELECT trial showed lenvatinib improved progression-free survival and response rates in patients with radioiodine-refractory differentiated thyroid cancer across different RAI-refractory definitions.
Randomized prospective study found adding I-125 brachytherapy to chemotherapy improved local control, response rate, and progression-free survival vs chemotherapy alone in locally recurrent stage III NSCLC.
Analysis of the SELECT trial showed lenvatinib improved progression-free survival and response rates in patients with radioiodine-refractory differentiated thyroid cancer across different RAI-refractory definitions.
Randomized trial comparing three iodinated contrast concentrations (300, 240, 140 mgI/mL) showing non-inferior operator confidence, significantly lower iodine load and less injection pain with the lowest concentration.
Randomized trial comparing three iodinated contrast concentrations (300, 240, 140 mgI/mL) showing non-inferior operator confidence, significantly lower iodine load and less injection pain with the lowest concentration.
Randomized trial comparing three iodinated contrast concentrations (300, 240, 140 mgI/mL) showing non-inferior operator confidence, significantly lower iodine load and less injection pain with the lowest concentration.
School lunch seasoning fortified with multiple micronutrients (including 50 μg iodine per serving) reduced respiratory and diarrheal morbidity and slightly improved a visual recall test, but did not change growth.
Adding percutaneous iodine-125 seed implantation to radiofrequency ablation reduced tumour recurrence and increased long-term survival in hepatocellular carcinoma patients compared with RFA alone.
Prospective study of CT‑guided iodine‑125 brachytherapy for bilateral lung metastases from colorectal cancer showed high procedural success, acceptable safety, improved local control and significantly longer overall survival versus symptomatic care.
Open randomized trial comparing I-125 seed interstitial brachytherapy vs local chemotherapy perfusion in advanced pancreatic cancer patients; tumor response, pain, tumor markers, and survival assessed.
Compared irradiation stent (125I seeds) versus conventional stent for malignant biliary obstruction; irradiation stent relieved jaundice and extended survival and patency.
Randomized trial comparing 131I-labeled Lipiodol versus chemoembolization for HCC: survival and tumor response were similar but 131I-Lipiodol had markedly better tolerance.
Large phase III trial found no significant improvement in 2-year progression-free or overall survival from adding I-131 tositumomab consolidation to CHOP+rituximab.
Adding percutaneous iodine-125 seed implantation to radiofrequency ablation reduced tumour recurrence and increased long-term survival in hepatocellular carcinoma patients compared with RFA alone.
Randomized trial found that placing an iodine-125 seed-loaded irradiation stent before TACE improved survival and reduced liver failure versus sorafenib+TACE.
Randomized trial testing intrahepatic 131I-lipiodol after liver cancer surgery found no clear survival benefit and a few radiation-related adverse events.
Adding percutaneous iodine-125 seed implantation to radiofrequency ablation reduced tumour recurrence and increased long-term survival in hepatocellular carcinoma patients compared with RFA alone.
Topical 0.6% PVP-iodine eye drops shortened disease resolution and reduced corneal complications versus hyaluronate tear substitute in adenoviral keratoconjunctivitis.
Topical 0.6% PVP-iodine eye drops shortened disease resolution and reduced corneal complications versus hyaluronate tear substitute in adenoviral keratoconjunctivitis.
Topical 0.6% PVP-iodine eye drops shortened disease resolution and reduced corneal complications versus hyaluronate tear substitute in adenoviral keratoconjunctivitis.
In adults having blood cultures drawn, skin prep with alcoholic chlorhexidine produced fewer contaminated blood cultures than aqueous 10% povidone-iodine.
Large randomized crossover study comparing skin antisepsis with chlorhexidine versus iodine tincture for blood cultures; found no difference in contamination rates.
Iodine tincture for venipuncture site antisepsis led to fewer blood culture contaminations than povidone-iodine.
In hospitalized adults, skin prep with alcohol+tincture of iodine yielded low blood culture contamination rates similar to alcohol+chlorhexidine.
2% alcoholic chlorhexidine reduced blood-culture contamination compared with 10% aqueous povidone‑iodine.
In children, chlorhexidine-alcohol skin prep led to fewer contaminated blood cultures than povidone-iodine preparations.
Crossover randomized trial evaluating 10% povidone iodine, 2% iodine tincture, and 2% chlorhexidine for blood culture skin antisepsis across 12,904 culture sets; no significant differences in contamination rates among agents.
When iodine delivery rate was held constant, contrast medium iodine concentration did not alter intracoronary enhancement or heart rate, but higher concentration/viscosity increased injection pressure.
When iodine delivery rate was held constant, contrast medium iodine concentration did not alter intracoronary enhancement or heart rate, but higher concentration/viscosity increased injection pressure.
When iodine delivery rate was held constant, contrast medium iodine concentration did not alter intracoronary enhancement or heart rate, but higher concentration/viscosity increased injection pressure.
Daily supplementation with 150 μg iodine in pregnancy improved maternal urinary iodine and urinary iodine excretion and reduced thyroglobulin compared with control, without changing maternal TSH/FT4 or neonatal TSH.
Daily 150 μg iodine supplementation for 24 weeks raised urinary iodine and reduced thyroglobulin levels in mildly iodine-deficient adults without changing TSH or free T4.
Daily supplementation with 150 μg iodine in pregnancy improved maternal urinary iodine and urinary iodine excretion and reduced thyroglobulin compared with control, without changing maternal TSH/FT4 or neonatal TSH.
Provision of supplements containing the WHO-recommended iodine dose (250 μg/day) did not change pregnant women's urinary iodine concentration at 36 weeks compared with iron–folic acid, likely because baseline iodine intakes were already adequate.
Spraying vitamin C solution after Lugol iodine staining reduced acute adverse reactions and sped decolorization of the esophageal mucosa compared with distilled water and performed similarly to sodium thiosulfate.
Spraying vitamin C solution after Lugol iodine staining reduced acute adverse reactions and sped decolorization of the esophageal mucosa compared with distilled water and performed similarly to sodium thiosulfate.
Spraying vitamin C solution after Lugol iodine staining reduced acute adverse reactions and sped decolorization of the esophageal mucosa compared with distilled water and performed similarly to sodium thiosulfate.
Using iodine-alcohol skin antisepsis before elective hip/knee replacement led to fewer surgical site infections than chlorhexidine-alcohol; no difference in superficial wound complications.
Large multicentre cluster-randomized trial found no meaningful difference in surgical-site infection risk between aqueous 10% povidone-iodine and aqueous 4% chlorhexidine for open-fracture surgery.
Large RCT comparing povidone-iodine wound irrigation versus no irrigation at cesarean section: no reduction in surgical site infection.
Using iodine-alcohol skin antisepsis before elective hip/knee replacement led to fewer surgical site infections than chlorhexidine-alcohol; no difference in superficial wound complications.
Applying povidone-iodine to the incision after skin closure did not reduce surgical site infections compared with no application.
Compared ciNPWT versus standard sterile gauze with an iodine disinfectant after ventral hernia repair; ciNPWT reduced infections numerically but increased hospital stay.
No difference in surgical-site infection rate between chlorhexidine gluconate and povidone-iodine for clean-contaminated abdominal surgery.
Microbial sealant was equivalent to standard povidone-iodine cleaning plus plain adhesive drape for skin preparation in cardiac surgery; no postoperative wound infections occurred.
Using iodine-alcohol skin antisepsis before elective hip/knee replacement led to fewer surgical site infections than chlorhexidine-alcohol; no difference in superficial wound complications.
In patients with diabetic kidney disease, moderate sodium restriction or hydrochlorothiazide alone did not change 24-h iodine excretion, but the combination produced a modest statistically significant reduction that remained above deficiency thresholds.
In patients with diabetic kidney disease, moderate sodium restriction or hydrochlorothiazide alone did not change 24-h iodine excretion, but the combination produced a modest statistically significant reduction that remained above deficiency thresholds.
In patients with diabetic kidney disease, moderate sodium restriction or hydrochlorothiazide alone did not change 24-h iodine excretion, but the combination produced a modest statistically significant reduction that remained above deficiency thresholds.
A fortified seasoning powder served with school lunch reduced the prevalence of urinary iodine deficiency and improved zinc status in children; no clear effect on anemia prevalence.
A fortified seasoning powder served with school lunch reduced the prevalence of urinary iodine deficiency and improved zinc status in children; no clear effect on anemia prevalence.
In thyroidectomized patients, radioactive iodine administration reduced the rise in serum FT4 after an LT4 challenge (most notably at 1 month); LT4 formulation (liquid vs tablet) did not change this effect.
In thyroidectomized patients, radioactive iodine administration reduced the rise in serum FT4 after an LT4 challenge (most notably at 1 month); LT4 formulation (liquid vs tablet) did not change this effect.
Among patients receiving prostate brachytherapy with iodine-125 or palladium-103 seeds, clinically diagnosed epididymitis occurred in 5 of 517 patients (≈1%).
A double-low CT protocol reduced radiation and iodine dose while maintaining similar image quality for aortic CTA.
Randomized volunteer study showing 70-kVp CT angiography improves vascular enhancement and image quality and allows reduced iodine contrast volume and lower radiation dose.
Using 80 kVp low-iodine contrast protocol with IMR in CABG patients reduced radiation and iodine load and improved image quality for aorta, left ventricle and venous grafts.
In 179 patients, a low-voltage/low-iodine CT protocol produced diagnostic coronary images while significantly lowering iodine intake and radiation dose.
Gadolinium-based contrast with dual-energy reconstructions can yield good pulmonary CT angiography; iodine-based iohexol gave highest attenuation but more SVC artifacts.
In very low birth weight preterm infants, oral iodine supplementation corrected iodine status and affected thyroid hormones but did not change Bayley-III composite neurodevelopmental scores at 24 months.
Randomized trial giving higher versus standard iodine in preterm formula; no change in thyroid hormone levels up to 41 weeks.
A PVP-iodine liposomal hydrogel accelerated wound epithelialization, improved healing quality and reduced graft loss compared with chlorhexidine gauze.
Randomized trial testing aromatherapy versus placebo in patients receiving radioactive iodine; aromatherapy groups showed improved salivary gland function on scintigraphy.
Randomized trial testing aromatherapy versus placebo in patients receiving radioactive iodine; aromatherapy groups showed improved salivary gland function on scintigraphy.
Randomized trial testing aromatherapy versus placebo in patients receiving radioactive iodine; aromatherapy groups showed improved salivary gland function on scintigraphy.
In patients with thyroid autonomy undergoing iodine exposure, short-term prophylactic antithyroid treatment blunted hormone changes compared with controls.
Randomized dietary trial where children ate liver meat balls for 90 days; urinary iodine, haemoglobin, and cognitive scores improved in the supplemented group.
Adding 150 µg iodine to individualized L-thyroxine increased urinary iodine and produced greater (though modest) reductions in thyroid volume and stronger TSH suppression versus L-thyroxine alone.
In 52 New Zealand women, urinary iodine excretion was low and showed no consistent trends during pregnancy or postpartum due to large variability.
Inhabitants with high cold exposure (hunters, settlement dwellers) showed signs of increased thyroid activity (higher thyroglobulin) and lower fT3 despite higher urinary iodine excretion.
Four weeks of kelp supplementation increased urinary iodine dose-dependently and raised TSH (both low- and high-dose) with high-dose kelp lowering total T3 and augmenting TRH-stimulated TSH response.
Low-dose iodine intake in endemic-goitre patients markedly increased urinary iodine and induced autoimmune thyroid changes in a subset (antibody rise, lymphocytic infiltration) with some developing hypo- or hyperthyroidism that mostly remitted after withdrawal.
Vegetarians and especially vegans had lower urinary iodine and higher prevalence of iodine deficiency compared with mixed-diet adults.
Randomized dietary trial where children ate liver meat balls for 90 days; urinary iodine, haemoglobin, and cognitive scores improved in the supplemented group.
Randomized dietary trial where children ate liver meat balls for 90 days; urinary iodine, haemoglobin, and cognitive scores improved in the supplemented group.
Randomized single-blind pilot trial comparing salso‑bromo‑iodine thermal water versus saline nasal douche in children with middle-ear effusion; iodine solution led to better tympanogram and hearing outcomes.
Randomized single-blind pilot trial comparing salso‑bromo‑iodine thermal water versus saline nasal douche in children with middle-ear effusion; iodine solution led to better tympanogram and hearing outcomes.
Randomized single-blind pilot trial comparing salso‑bromo‑iodine thermal water versus saline nasal douche in children with middle-ear effusion; iodine solution led to better tympanogram and hearing outcomes.
Prospective study of iodine replacement in endemic goitre and healthy controls over 1 year; small proportion developed low-level thyroid antibodies without clinical thyroid dysfunction.
Prospective study of iodine replacement in endemic goitre and healthy controls over 1 year; small proportion developed low-level thyroid antibodies without clinical thyroid dysfunction.
Prospective randomized imaging study showed that virtual monochromatic low-energy images with ~50% reduced iodine contrast provided diagnostic aortoiliac CTA with higher intravascular attenuation and lower radiation dose-length product.
Adjusting tube voltage and iodine delivery rate by weight in CCTA reduced contrast agent dose and radiation exposure while preserving or improving image quality.
A prospective randomized study comparing low iodine dose/injection rate and low radiation (with AI denoising) versus standard protocol showed higher vascular CT attenuation, lower iodine intake, and substantially lower radiation dose with maintained diagnostic image quality.
Screened elderly Chinese for thyroid problems; found thyroid dysfunction mainly in women, with possible contributions from autoimmunity and borderline iodine intake.
Short clinical study in HCV patients: excess iodine (with or without rIFN-alpha) caused small changes in thyroid function over 2 months.
6-month randomized, double-blind 2x2 trial in children: vitamin A supplementation decreased TSH stimulation, thyroglobulin, and thyroid volume and thus reduced goiter risk in the context of mild-to-moderate iodine deficiency.
Short-term high-dose iodine and iodide both raised TSH in healthy men; anticipated differential effects versus animal data were not observed.
In abdominal CT, two iodine concentrations produced similar vascular and liver enhancement; higher-concentration contrast had higher peak injection pressure.
In abdominal CT, two iodine concentrations produced similar vascular and liver enhancement; higher-concentration contrast had higher peak injection pressure.
After iodized oil administration, children's urinary iodine rose, goiter rates fell, and linear growth and puberty timing improved.
Pregnant women randomized to iodised salt or iodine supplements showed no difference in child neurodevelopment; prior long-term iodised salt use raised maternal urinary iodine and reduced thyroid volume.
Double-blind randomized trial in moderately iodine-deficient schoolchildren: Lipiodol increased urinary iodine but remained below normal and produced no short-term improvement in T4, TSH, weight, cognitive or motor tests at 4 months.
Daily 150 µg iodine for 28 weeks raised iodine status and produced small improvements in some cognitive tests in mildly iodine-deficient children.
Cluster randomized trial in 1602 children (4–6 years): market introduction of iodized salt increased children's urinary iodine but produced no overall improvement in cognitive/language test scores; some subgroup benefits observed.
Single oral dose of iodized oil corrected iodine deficiency and reduced goiter prevalence in schoolchildren for over a year.
A single oral iodised-oil dose increased urinary iodine and markedly reduced goitre prevalence at 40 weeks; efficacy was lower in children with poorer weight-for-height.
Eating farmed Atlantic salmon three times weekly for 16 weeks increased EPA/DHA biomarkers and modestly improved two raw cognitive subtest scores but did not change global IQ scores in preschool children.
In this cross-sectional pediatric survey iodine status was adequate and thyroid autoimmunity was present in a minority, more in females and older children.
Two weeks of a low‑iodine diet reduced urinary iodine similarly to three weeks and increased thyroid 131I uptake (numerically greater in 2-week group but not significantly different).
Patients with hyperthyroidism randomized to iodated vs non-iodated salt; antithyroid drug needs were tracked over 6 months.
Biscuits fortified with encapsulated ferrous sulfate plus potassium iodate raised women's iron stores and increased urinary iodine concentrations over 22 weeks.
Lower urinary iodine was observed in people with periodontitis; a cutoff <76.93 μg/L was associated with high probability of periodontitis in this small sample.
Dual-fortified salt improved iron status and reduced anemia; iodized salt and one dual-fortified formula increased urinary iodine, while the other iron formulation reduced iodine stability in salt.
Iodine deficiency was present in the population; goiter prevalence rose with age and urinary iodine fell, with higher neonatal TSH observed.
Removing iodized salt for about 1.5 years led to a large drop in children's goiter prevalence.
After iodized oil administration, children's urinary iodine rose, goiter rates fell, and linear growth and puberty timing improved.
In iron-deficient goitrous children, adding iron improved iron status and made iodized salt more effective, reducing thyroid size and goiter rates.
Single oral dose of iodized oil corrected iodine deficiency and reduced goiter prevalence in schoolchildren for over a year.
After iodized oil administration, children's urinary iodine rose, goiter rates fell, and linear growth and puberty timing improved.
A 6-month community cluster education program for women markedly raised knowledge, attitudes and practices related to iodized salt use.
Daily educational text messages improved women's knowledge and attitudes about iodine/iodized salt but did not change reported practice or urinary iodine.
A 6-month community cluster education program for women markedly raised knowledge, attitudes and practices related to iodized salt use.
Daily educational text messages improved women's knowledge and attitudes about iodine/iodized salt but did not change reported practice or urinary iodine.
Daily educational text messages improved women's knowledge and attitudes about iodine/iodized salt but did not change reported practice or urinary iodine.
In this cross-sectional pediatric survey iodine status was adequate and thyroid autoimmunity was present in a minority, more in females and older children.
In this cross-sectional pediatric survey iodine status was adequate and thyroid autoimmunity was present in a minority, more in females and older children.
In coronary CTA, iobitridol 350 mgI/mL was non-inferior to higher-concentration agents for image evaluability; higher iodine concentration gave higher absolute attenuation but similar SNR/CNR and slightly different AE rates.
In coronary CTA, iobitridol 350 mgI/mL was non-inferior to higher-concentration agents for image evaluability; higher iodine concentration gave higher absolute attenuation but similar SNR/CNR and slightly different AE rates.
Double-blind randomized trial of two iodine-containing contrast agents in cerebral angiography found similar diagnostic efficacy and no significant difference in adverse event rates.
In coronary CTA, iobitridol 350 mgI/mL was non-inferior to higher-concentration agents for image evaluability; higher iodine concentration gave higher absolute attenuation but similar SNR/CNR and slightly different AE rates.
Using higher iodine delivery rate with current modulation reduced radiation dose by ~19% while preserving image quality in head and neck CTA.
Using higher iodine delivery rate with current modulation reduced radiation dose by ~19% while preserving image quality in head and neck CTA.
In first- and second-degree perineal tears, surgical glue reduced postpartum perineal pain and shortened repair time, with overall similar healing but a higher short-term re-repair rate in the glue group.
In first- and second-degree perineal tears, surgical glue reduced postpartum perineal pain and shortened repair time, with overall similar healing but a higher short-term re-repair rate in the glue group.
In first- and second-degree perineal tears, surgical glue reduced postpartum perineal pain and shortened repair time, with overall similar healing but a higher short-term re-repair rate in the glue group.
At age 6–9 years, children conceived within 6 months after HSG with oil-based versus water-based iodinated contrast showed no differences in intelligence, behaviour, academic performance or most neurocognitive domains; a small advantage in visuomotor integration for oil-based contrast was observed but may be due to chance.
At age 6–9 years, children conceived within 6 months after HSG with oil-based versus water-based iodinated contrast showed no differences in intelligence, behaviour, academic performance or most neurocognitive domains; a small advantage in visuomotor integration for oil-based contrast was observed but may be due to chance.
At age 6–9 years, children conceived within 6 months after HSG with oil-based versus water-based iodinated contrast showed no differences in intelligence, behaviour, academic performance or most neurocognitive domains; a small advantage in visuomotor integration for oil-based contrast was observed but may be due to chance.
Dosing iodinated contrast by total body weight versus lean body weight produced similar magnitude and interpatient variability in normalized mean hepatic enhancement at routine abdominal CT, though TBW-based dosing used larger contrast volumes.
Dosing iodinated contrast by total body weight versus lean body weight produced similar magnitude and interpatient variability in normalized mean hepatic enhancement at routine abdominal CT, though TBW-based dosing used larger contrast volumes.
In high-risk PCI patients given iodinated contrast, IV prostaglandin E1 reduced the incidence of contrast-induced nephropathy versus control hydration alone.
In Chinese patients with differentiated thyroid cancer, low-dose (1.1 GBq) radioiodine ablation achieved similar ablation success rates to high-dose (3.7 GBq) at 6–8 months.
In Chinese patients with differentiated thyroid cancer, low-dose (1.1 GBq) radioiodine ablation achieved similar ablation success rates to high-dose (3.7 GBq) at 6–8 months.
In Chinese patients with differentiated thyroid cancer, low-dose (1.1 GBq) radioiodine ablation achieved similar ablation success rates to high-dose (3.7 GBq) at 6–8 months.
Chlorhexidine was not inferior to povidone-iodine for preventing symptomatic urinary tract infection within 2 weeks after urogynecologic surgery; secondary infection and irritation outcomes were similar.
Chlorhexidine was not inferior to povidone-iodine for preventing symptomatic urinary tract infection within 2 weeks after urogynecologic surgery; secondary infection and irritation outcomes were similar.
Chlorhexidine was not inferior to povidone-iodine for preventing symptomatic urinary tract infection within 2 weeks after urogynecologic surgery; secondary infection and irritation outcomes were similar.
Daily lipid-based supplement with 250 μg iodine did not raise urinary iodine concentrations in pregnant and postpartum women compared with iron–folic acid.
Lower tube voltage plus iterative reconstruction allowed a ~26% lower iodine load and ~35% lower radiation dose while keeping image quality similar.
In 179 patients, a low-voltage/low-iodine CT protocol produced diagnostic coronary images while significantly lowering iodine intake and radiation dose.
Randomized pediatric CT study showing lower-concentration iodinated contrast plus lower tube settings reduces iodine load and radiation while keeping image quality.
Lower-strength iodine contrast produced diagnostically excellent neck CTs with fewer immediate minor side effects than higher-strength contrast.
Pilot randomized CTA study showing dual-energy CT allows up to ~60% iodinated contrast volume reduction without loss of image quality.
A double-low CT protocol reduced radiation and iodine dose while maintaining similar image quality for aortic CTA.
Randomized trial showing that halving contrast volume and using low tube voltage (80 kV) yields higher arterial attenuation and substantially lower radiation dose with good image quality.
In postmenopausal women, 7 weeks of seaweed (high iodine) raised urinary iodine and produced a small increase in TSH; soy had no effect.
In patients with Hashimoto's hypothyroidism, restricting iodine intake for 3 months led many to recover normal thyroid function.
In men receiving iodine-125 brachytherapy plus EBRT, extending androgen-deprivation therapy to 30 months did not improve 7-year biochemical progression compared with 6 months.
In men receiving iodine-125 brachytherapy plus EBRT, extending androgen-deprivation therapy to 30 months did not improve 7-year biochemical progression compared with 6 months.
In men receiving iodine-125 brachytherapy plus EBRT, extending androgen-deprivation therapy to 30 months did not improve 7-year biochemical progression compared with 6 months.
Bethanechol given after radioactive iodine therapy reduced acute dry mouth and salivary gland symptoms and improved some short-term quality-of-life measures versus placebo.
Bethanechol given after radioactive iodine therapy reduced acute dry mouth and salivary gland symptoms and improved some short-term quality-of-life measures versus placebo.
Bethanechol given after radioactive iodine therapy reduced acute dry mouth and salivary gland symptoms and improved some short-term quality-of-life measures versus placebo.
Daily 150 μg iodine supplementation for 24 weeks raised urinary iodine and reduced thyroglobulin levels in mildly iodine-deficient adults without changing TSH or free T4.
Partially replacing animal proteins with plant proteins for 12 weeks lowered iodine intake and urinary iodine excretion in healthy adults.
A prospective randomized study comparing low iodine dose/injection rate and low radiation (with AI denoising) versus standard protocol showed higher vascular CT attenuation, lower iodine intake, and substantially lower radiation dose with maintained diagnostic image quality.
A 12‑week dietary intervention to increase protein meals in older adults raised overall protein and several micronutrient intakes, including iodine, driven by more animal‑derived protein foods.
Individualized dietary counseling in older caregivers increased protein intake, raised calcium intake modestly, and greatly increased use of vitamin D supplementation over 6 months.
In a small randomized subsample, an 8-week whole-food plant-based diet reduced weight, HbA1c and several cardiometabolic risk factors but decreased intake of some micronutrients including vitamin D and calcium.
Four-week randomized diet trial in women showing the Paleolithic diet led to greater short-term weight and fat loss and reduced dietary calcium intake compared to guidelines-based diet.
6-week RCT in healthy men replacing most red/processed meat with legumes; studied nutrient intakes and biomarkers including iodine intake and urinary iodine excretion.
A reduced-voltage CT protocol with lower-iodine concentration cut iodine dose and radiation while preserving image quality in patients with BMI 18.5–27.9.
An 8-week intensive lifestyle program in children with abdominal obesity increased diet quality and improved some micronutrient intakes including calcium and vitamin D, and reduced BMI-SDS.
In 179 patients, a low-voltage/low-iodine CT protocol produced diagnostic coronary images while significantly lowering iodine intake and radiation dose.
Randomized trial comparing long-term methimazole versus radioiodine in toxic multinodular goiter; most methimazole patients remained euthyroid while radioiodine commonly produced hypothyroidism.
Randomized trial comparing long-term methimazole versus radioiodine in toxic multinodular goiter; most methimazole patients remained euthyroid while radioiodine commonly produced hypothyroidism.
Randomized trial comparing long-term methimazole versus radioiodine in toxic multinodular goiter; most methimazole patients remained euthyroid while radioiodine commonly produced hypothyroidism.
Prospective randomized study of radioiodine ablation after rhTSH versus thyroid hormone withdrawal in 63 patients, assessing iodine biokinetics and dosimetry.
Prospective randomized study of radioiodine ablation after rhTSH versus thyroid hormone withdrawal in 63 patients, assessing iodine biokinetics and dosimetry.
Prospective randomized study of radioiodine ablation after rhTSH versus thyroid hormone withdrawal in 63 patients, assessing iodine biokinetics and dosimetry.
Double-blind, placebo-controlled trial in 133 infants comparing daily/weekly multiple-micronutrient tablets and iron/placebo on urinary iodine at 23 weeks; no significant differences between groups.
In moderately iodine‑deficient children, a single oral iodized oil dose improved iodine and thyroid status and produced significant gains on several cognitive and motor tests at 24 weeks.
Vegetarians and especially vegans had lower urinary iodine and higher prevalence of iodine deficiency compared with mixed-diet adults.
Double-blind, placebo-controlled trial in 133 infants comparing daily/weekly multiple-micronutrient tablets and iron/placebo on urinary iodine at 23 weeks; no significant differences between groups.
Giving mothers MMS raised iodine in breast milk but did not change infant growth at 3 months.
Giving mothers MMS raised iodine in breast milk but did not change infant growth at 3 months.
Giving mothers MMS raised iodine in breast milk but did not change infant growth at 3 months.
Pregnant women offered daily iodine had higher urinary iodine and fewer were at risk of deficiency, though >20% of supplemented women remained at risk.
A single dose of intra-arterial I-131 lipiodol after resection improved 5-year disease-free and overall survival versus observation; long-term (10-year) differences were not statistically significant.
A single dose of intra-arterial I-131 lipiodol after resection improved 5-year disease-free and overall survival versus observation; long-term (10-year) differences were not statistically significant.
A single dose of intra-arterial I-131 lipiodol after resection improved 5-year disease-free and overall survival versus observation; long-term (10-year) differences were not statistically significant.
Short course iopanoic acid rapidly restored euthyroidism and did not impair the efficacy or long-term outcomes of subsequent radioiodine therapy.
Short course iopanoic acid rapidly restored euthyroidism and did not impair the efficacy or long-term outcomes of subsequent radioiodine therapy.
Short course iopanoic acid rapidly restored euthyroidism and did not impair the efficacy or long-term outcomes of subsequent radioiodine therapy.
Cluster-randomized introduction of iodized salt improved maternal/child iodine status and produced a small but significant gain in child cognitive scores.
Cluster-randomized introduction of iodized salt improved maternal/child iodine status and produced a small but significant gain in child cognitive scores.
Cluster-randomized introduction of iodized salt improved maternal/child iodine status and produced a small but significant gain in child cognitive scores.
Both chlorhexidine-alcohol and iodine-alcohol skin preps effectively eliminated skin bacteria before lumbar spine surgery with no clear difference in post-closure cultures.
Both chlorhexidine-alcohol and iodine-alcohol skin preps effectively eliminated skin bacteria before lumbar spine surgery with no clear difference in post-closure cultures.
Double-blind RCT in older adults testing selenium, iodine, their combination, or placebo for 3 months; thyroid function, thyroglobulin, selenium status and urinary iodine measured.
Daily 150 µg iodine for 28 weeks raised iodine status and produced small improvements in some cognitive tests in mildly iodine-deficient children.
Daily 150 µg iodine for 28 weeks raised iodine status and produced small improvements in some cognitive tests in mildly iodine-deficient children.
Adding microencapsulated iron to iodized salt improved iron status and amplified the beneficial effects of iodine on thyroid size and function in goitrous, iron-deficient children.
In iron-deficient goitrous children, adding iron improved iron status and made iodized salt more effective, reducing thyroid size and goiter rates.
Adding microencapsulated iron to iodized salt improved iron status and amplified the beneficial effects of iodine on thyroid size and function in goitrous, iron-deficient children.
Cross-sectional study showing long-term environmental cadmium exposure alters urinary mineral balance, including increased urinary calcium.
In iodine-deficient children, salt fortified with iodine plus micronized iron increased hemoglobin and iron stores and improved urinary iodine and thyroid volume over 10 months.
Intraoperative diluted povidone-iodine irrigation caused a marked, transient rise in urinary iodine but did not change thyroid hormone levels through postoperative day 14.
Women consuming salt fortified with iron and iodine showed improved iron markers versus iodized-salt controls after ~8–9 months.
In preterm infants, iodine-containing contrast increased urinary iodine and improved PICC tip visualization but did not alter subsequent thyroid function (TSH).
Using multiple micronutrient-fortified salt in school meals improved markers of iron status but did not change urinary iodine or serum ferritin over one year.
Single oral doses of iodized oil (200–800 mg iodine) normalized urinary iodine and thyroid hormones for about one year and reduced goiter in about two-thirds of adults.
Children eating salt fortified with multiple micronutrients including iodine for one year showed better micronutrient status and improvements on several memory and attention tests.
Small RCT showing povidone-iodine oral irrigation causes rapid increase in serum and urinary iodine but did not change thyroxine levels in the short term.
A fortified biscuit increased urinary iodine and improved vitamin A and iron markers during school terms, but many gains (except urinary iodine) fell back after long school holidays.
Fortified salt containing iodine and other micronutrients given to children and women for 8 months improved iron and zinc status and reduced anemia; urinary iodine was maintained in the fortified group.
Fortified biscuits (including iodine) increased iodine and other micronutrient status and reduced anemia in primary schoolchildren and improved deworming effectiveness.
Intraoperative diluted povidone-iodine irrigation caused a marked, transient rise in urinary iodine but did not change thyroid hormone levels through postoperative day 14.
Randomized trial (12-year follow-up) comparing long-term methimazole versus radioactive iodine for toxic multinodular goiter found faster and more sustained euthyroidism with methimazole.
Randomized trial (12-year follow-up) comparing long-term methimazole versus radioactive iodine for toxic multinodular goiter found faster and more sustained euthyroidism with methimazole.
Randomized trial (12-year follow-up) comparing long-term methimazole versus radioactive iodine for toxic multinodular goiter found faster and more sustained euthyroidism with methimazole.
Randomized trial in advanced pancreatic cancer reported longer median survival with I-125 seed implantation plus arterial infusion chemotherapy versus systemic chemotherapy.
Adding an iodine-125 seed strand to TACE improved survival compared with TACE alone in patients with hepatocellular carcinoma and portal vein tumor thrombosis.
Randomized trial in advanced pancreatic cancer reported longer median survival with I-125 seed implantation plus arterial infusion chemotherapy versus systemic chemotherapy.
Randomized trial in advanced pancreatic cancer reported longer median survival with I-125 seed implantation plus arterial infusion chemotherapy versus systemic chemotherapy.
In diabetic patients with central serous retinopathy, lecithin-bound iodine produced numerically greater improvement than spironolactone over 6 months but differences were not statistically significant.
In diabetic patients with central serous retinopathy, lecithin-bound iodine produced numerically greater improvement than spironolactone over 6 months but differences were not statistically significant.
In diabetic patients with central serous retinopathy, lecithin-bound iodine produced numerically greater improvement than spironolactone over 6 months but differences were not statistically significant.
In overweight iodine-deficient women, daily 200 μg iodine for 6 months increased urinary iodine and reduced total cholesterol and the prevalence of hypercholesterolemia.
In overweight iodine-deficient women, daily 200 μg iodine for 6 months increased urinary iodine and reduced total cholesterol and the prevalence of hypercholesterolemia.
In nontoxic nodular goiter, 131I therapy reduced goiter size substantially more than suppressive levothyroxine but caused more hypothyroidism; levothyroxine caused bone loss.
Randomized comparison of two fixed radioactive‑iodine doses in drug‑resistant Graves' disease showing the higher 370 MBq dose produced substantially greater overall treatment response but higher rates of hypothyroidism.
In elderly patients with subclinical hyperthyroidism, radioiodine led to more hypothyroidism while long-term low‑dose methimazole maintained euthyroidism in most patients over 60 months.
Radioiodine reduced thyroid volume substantially; adjunct lithium prevented early radioiodine-induced hyperthyroidism.
In elderly patients with subclinical hyperthyroidism, radioiodine led to more hypothyroidism while long-term low‑dose methimazole maintained euthyroidism in most patients over 60 months.
Patients reported fewer unpleasant experiences and adverse events with povidone-iodine nasal decolonization compared with mupirocin.
Using 2% chlorhexidine in alcohol for skin disinfection was associated with a lower risk of catheter-related infection compared with alcoholic povidone-iodine in ICU patients.
In elderly patients with subclinical hyperthyroidism, radioiodine led to more hypothyroidism while long-term low‑dose methimazole maintained euthyroidism in most patients over 60 months.
Using a lower-iodine concentration contrast agent produced image quality similar to a higher-iodine agent and had slightly fewer adverse events.
Giving recombinant human TSH before radioiodine therapy led to greater thyroid size reduction but much higher rates of permanent hypothyroidism.
In 504 low-risk thyroid cancer patients, omission of postoperative radioiodine ablation was non-inferior to ablation for 5-year recurrence-free survival; adverse events were similar.
Iomeprol-400 produced greater arterial and portal venous enhancement on MDCT than iodixanol-320 with similar safety profiles.
Iodopovidone pleurodesis in malignant pleural effusion caused frequent adverse events and raised CRP; efficacy and quality of life were similar for 1% and 2% doses.
Randomized double-blind multicenter trial found povidone iodine and dequalinium chloride equivalently improved vaginal infection symptoms with good tolerability.
In this small pilot RCT povidone‑iodine showed similar wound healing time to honey and paraffin gauze with no statistically significant differences.
Two weeks of a low‑iodine diet reduced urinary iodine similarly to three weeks and increased thyroid 131I uptake (numerically greater in 2-week group but not significantly different).
Adjusting tube voltage and iodine delivery rate by weight in CCTA reduced contrast agent dose and radiation exposure while preserving or improving image quality.
Adjusting tube voltage and iodine delivery rate by weight in CCTA reduced contrast agent dose and radiation exposure while preserving or improving image quality.
Absence of iodine staining at baseline endoscopy identified lesions at higher risk of progression to severe dysplasia or esophageal cancer; a prediction model combining staining and clinical features performed well.
Absence of iodine staining at baseline endoscopy identified lesions at higher risk of progression to severe dysplasia or esophageal cancer; a prediction model combining staining and clinical features performed well.
In a double-blind RCT, 1% iodine caused less patient-reported heartburn/retrosternal pain than 2% iodine during chromoendoscopy, with equivalent staining quality.
In a double-blind RCT, 1% iodine caused less patient-reported heartburn/retrosternal pain than 2% iodine during chromoendoscopy, with equivalent staining quality.
Povidone-iodine pleurodesis reduced drainage time and hospital stay versus surveillance with acceptable complications.
In 460 untreated hyperthyroid patients followed ~9 years, radioiodine (131I) produced higher cure rates and lower recurrence but more hypothyroidism versus antithyroid drugs.
Adding iodine-131 to levothyroxine after thyroid cancer surgery improved response rate and reduced one-year recurrence without increasing side effects.
In 228 low-risk DTC patients randomized to low- (1850 MBq) or high-dose (3700 MBq) radioiodine, long-term recurrence, survival, and biochemical outcomes were similar between doses.
Sentinel lymph node biopsy detected occult lateral metastases but did not change stimulated thyroglobulin after ablation or recurrence rates at median 39-month follow-up.
In 228 low-risk DTC patients randomized to low- (1850 MBq) or high-dose (3700 MBq) radioiodine, long-term recurrence, survival, and biochemical outcomes were similar between doses.
In 228 low-risk DTC patients randomized to low- (1850 MBq) or high-dose (3700 MBq) radioiodine, long-term recurrence, survival, and biochemical outcomes were similar between doses.
In rural Ghana, double-fortified salt (iron+iodine) prevented an increase in women's anemia and reduced anemia in children versus iodised salt alone, while iodine status improved similarly across groups.
In rural Ghana, double-fortified salt (iron+iodine) prevented an increase in women's anemia and reduced anemia in children versus iodised salt alone, while iodine status improved similarly across groups.
In rural Ghana, double-fortified salt (iron+iodine) prevented an increase in women's anemia and reduced anemia in children versus iodised salt alone, while iodine status improved similarly across groups.
In a randomized trial of women undergoing breast-conserving surgery, use of iodine-125 seed localisation (ROLLIS) produced significantly less patient-reported stress and discomfort than hookwire localisation.
In a randomized trial of women undergoing breast-conserving surgery, use of iodine-125 seed localisation (ROLLIS) produced significantly less patient-reported stress and discomfort than hookwire localisation.
Parotid gland massage during high-dose radioactive iodine therapy reduced serum amylase rise and lowered the rate of parotid salivary gland dysfunction on 8-month scintigraphy.
Parotid gland massage during high-dose radioactive iodine therapy reduced serum amylase rise and lowered the rate of parotid salivary gland dysfunction on 8-month scintigraphy.
One-year multicenter community trial: double-fortified salt (iron + iodine) was stable in storage and improved hemoglobin and corrected iodine deficiency similarly to iodized salt; DFS increased hemoglobin more than iodized salt.
Fortified salt containing iodine and other micronutrients given to children and women for 8 months improved iron and zinc status and reduced anemia; urinary iodine was maintained in the fortified group.
10-month double-blind randomized trial in schoolchildren showed triple-fortified salt improved hemoglobin, iron stores, and vitamin A status vs iodized salt.
Women consuming salt fortified with iron and iodine showed improved iron markers versus iodized-salt controls after ~8–9 months.
In iodine-deficient children, salt fortified with iodine plus micronized iron increased hemoglobin and iron stores and improved urinary iodine and thyroid volume over 10 months.
Children given multiple-micronutrient fortified salt (includes iodine) had better blood nutrient markers and improved memory compared with iodized-salt controls.
In iodine-deficient children, salt fortified with iodine plus micronized iron increased hemoglobin and iron stores and improved urinary iodine and thyroid volume over 10 months.
A 6-month community cluster education program for women markedly raised knowledge, attitudes and practices related to iodized salt use.
Short-course lithium before radioiodine increased thyroid iodide uptake, lowered circulating T3/T4 levels, and improved early radioiodine therapy outcomes in hyperthyroid patients.
Short-course lithium before radioiodine increased thyroid iodide uptake, lowered circulating T3/T4 levels, and improved early radioiodine therapy outcomes in hyperthyroid patients.
Short-course lithium before radioiodine increased thyroid iodide uptake, lowered circulating T3/T4 levels, and improved early radioiodine therapy outcomes in hyperthyroid patients.
In a pilot randomized trial, molecular iodine (5 mg/day) given perioperatively (and with chemotherapy in advanced cases) activated antitumor immune pathways and induced epigenetic changes in breast tumors.
In a pilot randomized trial, molecular iodine (5 mg/day) given perioperatively (and with chemotherapy in advanced cases) activated antitumor immune pathways and induced epigenetic changes in breast tumors.
In a pilot randomized trial, molecular iodine (5 mg/day) given perioperatively (and with chemotherapy in advanced cases) activated antitumor immune pathways and induced epigenetic changes in breast tumors.
In a pilot randomized trial, molecular iodine (5 mg/day) given perioperatively (and with chemotherapy in advanced cases) activated antitumor immune pathways and induced epigenetic changes in breast tumors.
In a pilot randomized trial, molecular iodine (5 mg/day) given perioperatively (and with chemotherapy in advanced cases) activated antitumor immune pathways and induced epigenetic changes in breast tumors.
Forty patients underwent CT angiography with a low-iodine contrast protocol; image quality remained diagnostic while iodine dose and radiation dose were reduced.
Randomized whole-body CTA trial showing that low tube voltage with low-concentration contrast reduces iodine load and radiation while preserving vascular enhancement and image quality.
In 255 patients, deep learning image reconstruction plus high-concentration iodinated contrast enabled a double-low protocol (lower radiation and lower contrast volume) while maintaining or improving image quality.
In 120 patients, low-iodine-concentration contrast (iodixanol 270 mgI/ml) with low tube voltage and iterative reconstruction achieved comparable image quality to higher-concentration contrast while substantially reducing radiation dose.
Using lower-concentration iodine contrast with lower tube voltage reduced radiation and kept acceptable image quality.
Lower tube voltage plus iterative reconstruction allowed a ~26% lower iodine load and ~35% lower radiation dose while keeping image quality similar.
Low tube voltage + low-concentration contrast and iterative reconstruction produced similar image quality with lower radiation and iodine dose.
Prospective comparison of 80 kVp with moderate-concentration iodinated contrast vs 120 kVp with high-concentration contrast for renal CTA in 50 patients.
Using 80 kVp plus iterative reconstruction allowed reduction of iodine contrast dose while maintaining or improving some image metrics and lowering radiation dose.
A personalized diluted contrast protocol with a test bolus produced diagnostic craniocervical CTA while significantly reducing radiation dose and iodine uptake.
Compared low- vs high-iodine contrast protocols in 100 patients undergoing aortic CT to assess image quality, radiation dose, and adverse effects.
Women consuming salt fortified with iron and iodine showed improved iron markers versus iodized-salt controls after ~8–9 months.
Biscuits fortified with encapsulated ferrous sulfate plus potassium iodate raised women's iron stores and increased urinary iodine concentrations over 22 weeks.
A fortified biscuit increased urinary iodine and improved vitamin A and iron markers during school terms, but many gains (except urinary iodine) fell back after long school holidays.
Fortified biscuits (including iodine) increased iodine and other micronutrient status and reduced anemia in primary schoolchildren and improved deworming effectiveness.
88 patients with Graves' were randomized to different I-131 dosing methods; no dosing method proved superior.
88 patients with Graves' were randomized to different I-131 dosing methods; no dosing method proved superior.
88 patients with Graves' were randomized to different I-131 dosing methods; no dosing method proved superior.
Children with URTI and postnasal drip received salso-bromo-iodine thermal water or saline; the iodine-containing solution improved cough-related outcomes.
Children with URTI and postnasal drip received salso-bromo-iodine thermal water or saline; the iodine-containing solution improved cough-related outcomes.
Children with URTI and postnasal drip received salso-bromo-iodine thermal water or saline; the iodine-containing solution improved cough-related outcomes.
Children with URTI and postnasal drip received salso-bromo-iodine thermal water or saline; the iodine-containing solution improved cough-related outcomes.
Children with URTI and postnasal drip received salso-bromo-iodine thermal water or saline; the iodine-containing solution improved cough-related outcomes.
Using multiple micronutrient-fortified salt in school meals improved markers of iron status but did not change urinary iodine or serum ferritin over one year.
Women consuming salt fortified with iron and iodine showed improved iron markers versus iodized-salt controls after ~8–9 months.
Women consuming salt fortified with iron and iodine showed improved iron markers versus iodized-salt controls after ~8–9 months.
Seventy patients randomized to contrast media with 300 vs 370 mg/ml iodine; overall enhancement was similar between concentrations.
Seventy patients randomized to contrast media with 300 vs 370 mg/ml iodine; overall enhancement was similar between concentrations.
Seventy patients randomized to contrast media with 300 vs 370 mg/ml iodine; overall enhancement was similar between concentrations.
10-month double-blind randomized trial in schoolchildren showed triple-fortified salt improved hemoglobin, iron stores, and vitamin A status vs iodized salt.
10-month double-blind randomized trial in schoolchildren showed triple-fortified salt improved hemoglobin, iron stores, and vitamin A status vs iodized salt.
10-month double-blind randomized trial in schoolchildren showed triple-fortified salt improved hemoglobin, iron stores, and vitamin A status vs iodized salt.
240 patients randomized to ChloraPrep, DuraPrep, or Betadine (povidone-iodine); DuraPrep and Betadine produced fewer positive post-prep cultures than ChloraPrep.
240 patients randomized to ChloraPrep, DuraPrep, or Betadine (povidone-iodine); DuraPrep and Betadine produced fewer positive post-prep cultures than ChloraPrep.
I-131–labeled Metuximab preferentially accumulates in hepatocellular carcinoma lesions with best tumor:nontumor contrast at ~192 hours.
I-131–labeled Metuximab preferentially accumulates in hepatocellular carcinoma lesions with best tumor:nontumor contrast at ~192 hours.
I-131–labeled Metuximab preferentially accumulates in hepatocellular carcinoma lesions with best tumor:nontumor contrast at ~192 hours.
Coated iodine-125 prostate seeds reduced apical seed loss and overall seed loss versus regular loose seeds at 30 days postimplant.
Coated iodine-125 prostate seeds reduced apical seed loss and overall seed loss versus regular loose seeds at 30 days postimplant.
Coated iodine-125 prostate seeds reduced apical seed loss and overall seed loss versus regular loose seeds at 30 days postimplant.
In low-risk thyroid cancer, low-activity (1.1 GBq) radioactive iodine ablation was equivalent to high-activity (3.7 GBq); 98% had no evidence of disease at ~5 years.
In low-risk thyroid cancer, low-activity (1.1 GBq) radioactive iodine ablation was equivalent to high-activity (3.7 GBq); 98% had no evidence of disease at ~5 years.
I-125 seed brachytherapy for lung cancer produced better local tumor control and fewer complications than EBRT; I-125 environmental radiation decreased quickly with time/distance and was blocked by lead aprons.
I-125 seed brachytherapy for lung cancer produced better local tumor control and fewer complications than EBRT; I-125 environmental radiation decreased quickly with time/distance and was blocked by lead aprons.
I-125 seed brachytherapy for lung cancer produced better local tumor control and fewer complications than EBRT; I-125 environmental radiation decreased quickly with time/distance and was blocked by lead aprons.
Combining GSI and ASIR in abdominal CT reduced iodine contrast dose (~14%) and radiation dose (~41%) in higher-BMI patients while maintaining diagnostic image quality.
Reducing injection rate and contrast dose (iodine-containing agent) in 3D DSA was feasible and produced satisfactory images.
Combining GSI and ASIR in abdominal CT reduced iodine contrast dose (~14%) and radiation dose (~41%) in higher-BMI patients while maintaining diagnostic image quality.
Low tube voltage + low-concentration contrast and iterative reconstruction produced similar image quality with lower radiation and iodine dose.
Combining GSI and ASIR in abdominal CT reduced iodine contrast dose (~14%) and radiation dose (~41%) in higher-BMI patients while maintaining diagnostic image quality.
Radioactive iodine (RAI) ablation increased inflammatory cytokines (notably IL-6); therapeutic omega-3 given after RAI produced greater anti-inflammatory effects than prophylactic use before RAI.
Radioactive iodine (RAI) ablation increased inflammatory cytokines (notably IL-6); therapeutic omega-3 given after RAI produced greater anti-inflammatory effects than prophylactic use before RAI.
Radioactive iodine (RAI) ablation increased inflammatory cytokines (notably IL-6); therapeutic omega-3 given after RAI produced greater anti-inflammatory effects than prophylactic use before RAI.
In 57 patients with pancreatic cancer, CT imaging at 80kVp showed that 0.3 gI/kg was the minimum iodine load needed to detect tumors.
In 57 patients with pancreatic cancer, CT imaging at 80kVp showed that 0.3 gI/kg was the minimum iodine load needed to detect tumors.
In 40 men randomized to high- or low-activity 125I seeds, higher-activity seeds improved dose coverage, reduced cost, and shortened operating time.
In 40 men randomized to high- or low-activity 125I seeds, higher-activity seeds improved dose coverage, reduced cost, and shortened operating time.
In 40 men randomized to high- or low-activity 125I seeds, higher-activity seeds improved dose coverage, reduced cost, and shortened operating time.
In 52 New Zealand women, urinary iodine excretion was low and showed no consistent trends during pregnancy or postpartum due to large variability.
In 208 Thai pregnant women, universal and targeted iodine supplementation were similarly effective at preventing deficiency, but universal supplementation produced more women with iodine above requirement.
In 208 Thai pregnant women, universal and targeted iodine supplementation were similarly effective at preventing deficiency, but universal supplementation produced more women with iodine above requirement.
In 2013 women undergoing unscheduled cesarean, the type of skin preparation (including iodine-alcohol) was not associated with differences in postoperative surgical site infection rates.
Randomized study in clean and potentially contaminated operations found similar surgical site infection incidence between povidone-iodine and chlorhexidine preparations.
In a review of 170 surgeries, complication rates were similar between iodine-125 seed localization and hook-wire localization for breast-conserving surgery.
Compared a sequential thyroid defunctionalization preoperative method to conventional antithyroid drugs plus iodine; the test method reduced bleeding and complications.
In a review of 170 surgeries, complication rates were similar between iodine-125 seed localization and hook-wire localization for breast-conserving surgery.
In a review of 170 surgeries, complication rates were similar between iodine-125 seed localization and hook-wire localization for breast-conserving surgery.
In thyroid cancer patients given therapeutic 131I, sucking vitamin C at various times had only a limited effect on salivary radioiodine dose.
In thyroid cancer patients given therapeutic 131I, sucking vitamin C at various times had only a limited effect on salivary radioiodine dose.
In thyroid cancer patients given therapeutic 131I, sucking vitamin C at various times had only a limited effect on salivary radioiodine dose.
In infants given oral iodized oil at first OPV dose, iodized oil did not reduce neutralizing antibody responses to poliovirus serotypes 1–3.
In infants given oral iodized oil at first OPV dose, iodized oil did not reduce neutralizing antibody responses to poliovirus serotypes 1–3.
In infants given oral iodized oil at first OPV dose, iodized oil did not reduce neutralizing antibody responses to poliovirus serotypes 1–3.
Providing lipid-based nutrient supplements containing iodine to young children in a region with iodised salt did not change urinary iodine, TSH, or T4 at 18 months compared with controls.
Providing lipid-based nutrient supplements containing iodine to young children in a region with iodised salt did not change urinary iodine, TSH, or T4 at 18 months compared with controls.
Providing lipid-based nutrient supplements containing iodine to young children in a region with iodised salt did not change urinary iodine, TSH, or T4 at 18 months compared with controls.
Daily 225 µg iodine from first trimester increased maternal iodine status, lowered maternal thyroglobulin and altered TSH trends, without adverse thyroid hormone changes.
Daily 225 µg iodine from first trimester increased maternal iodine status, lowered maternal thyroglobulin and altered TSH trends, without adverse thyroid hormone changes.
Daily 225 µg iodine from first trimester increased maternal iodine status, lowered maternal thyroglobulin and altered TSH trends, without adverse thyroid hormone changes.
Patients with short gut and on parenteral nutrition had similar iodine intake and urinary iodine excretion to controls, indicating maintained iodine status.
Patients with short gut and on parenteral nutrition had similar iodine intake and urinary iodine excretion to controls, indicating maintained iodine status.
Patients with short gut and on parenteral nutrition had similar iodine intake and urinary iodine excretion to controls, indicating maintained iodine status.
12-week RCT in women of childbearing age: increasing cow milk intake raised urinary iodine concentration but did not change thyroid hormone or selenium measures.
Iodine administration normalized thyroid tests and improved growth; adding selenium did not alter established disease outcomes at 12 months.
Children given multiple-micronutrient fortified salt (includes iodine) had better blood nutrient markers and improved memory compared with iodized-salt controls.
Children given multiple-micronutrient fortified salt (includes iodine) had better blood nutrient markers and improved memory compared with iodized-salt controls.
In patients with very large multinodular goiters, giving 0.3 mg rhTSH before I-131 improved thyroid shrinkage but increased transient adverse effects.
Giving recombinant human TSH before radioiodine therapy led to greater thyroid size reduction but much higher rates of permanent hypothyroidism.
Giving recombinant human TSH before radioiodine therapy led to greater thyroid size reduction but much higher rates of permanent hypothyroidism.
In patients treated with radioiodine, chewing gum did not change parotid gland radioiodine counts in the first 48 hours nor salivary symptoms at 6 months.
In patients treated with radioiodine, chewing gum did not change parotid gland radioiodine counts in the first 48 hours nor salivary symptoms at 6 months.
Higher radioiodine activity (1110 MBq) produced greater one-year treatment success than lower activity (555 MBq); dose and patient factors influenced outcome.
Higher radioiodine activity (1110 MBq) produced greater one-year treatment success than lower activity (555 MBq); dose and patient factors influenced outcome.
In an iodine-deficient region, patients with metabolic syndrome had larger thyroid volumes and more nodules than matched controls.
In an iodine-deficient region, patients with metabolic syndrome had larger thyroid volumes and more nodules than matched controls.
Pilot study of 36 pregnant/lactating women given 150 µg/day iodine from 20 weeks gestation; urinary and breast milk iodine measured.
Randomized trial in 80 mother–infant pairs: daily iodine‑fortified milk for 4 weeks increased maternal urinary iodine and breast‑milk iodine compared with control; infant iodine status showed no significant adjusted change.
In moderately iodine-deficient Gambian women, prenatal MMN containing 300 μg iodine improved maternal iodine biomarkers during pregnancy and reduced maternal thyroglobulin, but had minimal impact on maternal thyroid hormones and limited postnatal benefit for breastmilk or infant iodine status.
Supplementing lactating women with 75 or 150 μg I/day raised maternal urinary iodine and breast-milk iodine but did not fully correct iodine deficiency in mothers or infants.
Randomized trial in 80 mother–infant pairs: daily iodine‑fortified milk for 4 weeks increased maternal urinary iodine and breast‑milk iodine compared with control; infant iodine status showed no significant adjusted change.
In moderately iodine-deficient Gambian women, prenatal MMN containing 300 μg iodine improved maternal iodine biomarkers during pregnancy and reduced maternal thyroglobulin, but had minimal impact on maternal thyroid hormones and limited postnatal benefit for breastmilk or infant iodine status.
Randomized trial in 80 mother–infant pairs: daily iodine‑fortified milk for 4 weeks increased maternal urinary iodine and breast‑milk iodine compared with control; infant iodine status showed no significant adjusted change.
Cluster randomized trial in 1602 children (4–6 years): market introduction of iodized salt increased children's urinary iodine but produced no overall improvement in cognitive/language test scores; some subgroup benefits observed.
Randomized study in 33 patients comparing 50 ml vs 100 ml iodinated contrast at different tube voltages: low‑volume (50 ml) at low kV provided non‑inferior vascular enhancement for pulmonary CTA.
Randomized study in 33 patients comparing 50 ml vs 100 ml iodinated contrast at different tube voltages: low‑volume (50 ml) at low kV provided non‑inferior vascular enhancement for pulmonary CTA.
Randomized study in 33 patients comparing 50 ml vs 100 ml iodinated contrast at different tube voltages: low‑volume (50 ml) at low kV provided non‑inferior vascular enhancement for pulmonary CTA.
Crossover randomized trial evaluating 10% povidone iodine, 2% iodine tincture, and 2% chlorhexidine for blood culture skin antisepsis across 12,904 culture sets; no significant differences in contamination rates among agents.
Over ~14 years, continuous methimazole had better mood/cognition and fewer thyroid, lipid, and some cardiac abnormalities than radioiodine replacement.
Over ~14 years, continuous methimazole had better mood/cognition and fewer thyroid, lipid, and some cardiac abnormalities than radioiodine replacement.
Over ~14 years, continuous methimazole had better mood/cognition and fewer thyroid, lipid, and some cardiac abnormalities than radioiodine replacement.
In Graves' patients with rapid I-131 turnover, the highest I-131 dose (7.4 MBq/g) gave the best 12-month cure rate with fewer side effects than lower-dose regimens with lithium.
In Graves' patients with rapid I-131 turnover, the highest I-131 dose (7.4 MBq/g) gave the best 12-month cure rate with fewer side effects than lower-dose regimens with lithium.
In Graves' patients with rapid I-131 turnover, the highest I-131 dose (7.4 MBq/g) gave the best 12-month cure rate with fewer side effects than lower-dose regimens with lithium.
Lower urinary iodine was observed in people with periodontitis; a cutoff <76.93 μg/L was associated with high probability of periodontitis in this small sample.
Dual-energy CT at 40 keV allowed a 50% reduction in iodine contrast while maintaining or increasing vascular contrast and SNR, but worsened intrapelvic arterial visualization and increased radiation dose slightly.
In 255 patients, deep learning image reconstruction plus high-concentration iodinated contrast enabled a double-low protocol (lower radiation and lower contrast volume) while maintaining or improving image quality.
Dual-energy CT at 40 keV allowed a 50% reduction in iodine contrast while maintaining or increasing vascular contrast and SNR, but worsened intrapelvic arterial visualization and increased radiation dose slightly.
Dual-energy CT at 40 keV allowed a 50% reduction in iodine contrast while maintaining or increasing vascular contrast and SNR, but worsened intrapelvic arterial visualization and increased radiation dose slightly.
A single very low dose (0.03 mg) rhTSH markedly increased thyroid radioactive iodine uptake and was well tolerated without lasting thyroid dysfunction at 8 weeks.
A single very low dose (0.03 mg) rhTSH markedly increased thyroid radioactive iodine uptake and was well tolerated without lasting thyroid dysfunction at 8 weeks.
A single very low dose (0.03 mg) rhTSH markedly increased thyroid radioactive iodine uptake and was well tolerated without lasting thyroid dysfunction at 8 weeks.
Dual-fortified salt improved iron status and reduced anemia; iodized salt and one dual-fortified formula increased urinary iodine, while the other iron formulation reduced iodine stability in salt.
Late cord clamping (60 s) was associated with higher neonatal FT3/FT4 and fewer neonates with low vitamin B12 compared with early clamping (≤10 s); urinary iodine results were measured but not emphasized.
Late cord clamping (60 s) was associated with higher neonatal FT3/FT4 and fewer neonates with low vitamin B12 compared with early clamping (≤10 s); urinary iodine results were measured but not emphasized.
Late cord clamping (60 s) was associated with higher neonatal FT3/FT4 and fewer neonates with low vitamin B12 compared with early clamping (≤10 s); urinary iodine results were measured but not emphasized.
Randomized trial in DTC patients receiving I-131 comparing antiemetics; ondansetron reduced post-radioiodine nausea versus placebo, pantoprazole and metoclopramide did not.
Randomized trial in DTC patients receiving I-131 comparing antiemetics; ondansetron reduced post-radioiodine nausea versus placebo, pantoprazole and metoclopramide did not.
Small randomized trial comparing two 125I radiation dose regimens with episcleral hyperthermia in uveal melanoma; outcomes were similar between dose groups.
Small randomized trial comparing two 125I radiation dose regimens with episcleral hyperthermia in uveal melanoma; outcomes were similar between dose groups.
Small randomized trial comparing two 125I radiation dose regimens with episcleral hyperthermia in uveal melanoma; outcomes were similar between dose groups.
Two long-term dietary patterns affected several serum minerals over 24 months; serum calcium showed no significant change while other minerals (selenium, manganese, magnesium) increased and serum zinc decreased.
Small RCT showing povidone-iodine oral irrigation causes rapid increase in serum and urinary iodine but did not change thyroxine levels in the short term.
Small RCT showing povidone-iodine oral irrigation causes rapid increase in serum and urinary iodine but did not change thyroxine levels in the short term.
Randomized trial testing excess iodate supplementation (various doses with/without selenium) in older adults; excess iodate markedly increased urinary iodine and induced transient thyroid dysfunction in some participants.
Randomized trial testing excess iodate supplementation (various doses with/without selenium) in older adults; excess iodate markedly increased urinary iodine and induced transient thyroid dysfunction in some participants.
Randomized trial testing excess iodate supplementation (various doses with/without selenium) in older adults; excess iodate markedly increased urinary iodine and induced transient thyroid dysfunction in some participants.
In mildly iodine-deficient Beninese children higher thyroglobulin was linked to worse high-frequency hearing and lower non-verbal test performance.
In mildly iodine-deficient Beninese children higher thyroglobulin was linked to worse high-frequency hearing and lower non-verbal test performance.
Inhabitants with high cold exposure (hunters, settlement dwellers) showed signs of increased thyroid activity (higher thyroglobulin) and lower fT3 despite higher urinary iodine excretion.
In mildly iodine-deficient Beninese children higher thyroglobulin was linked to worse high-frequency hearing and lower non-verbal test performance.
Randomized trial with >10-year follow-up (analyzed n=151) comparing total thyroidectomy alone vs with prophylactic central compartment lymph node dissection: no differences in oncologic outcomes or rates of permanent hypocalcemia or serum calcium at long-term follow-up.
Giving pregnant women cod twice weekly did not change general infant development but improved infant socio-emotional scores in the first months.
Giving pregnant women cod twice weekly did not change general infant development but improved infant socio-emotional scores in the first months.
Short-term high-dose iodine and iodide both raised TSH in healthy men; anticipated differential effects versus animal data were not observed.
Topical combination of tea tree oil plus organically bound iodine cleared molluscum lesions in most children, whereas iodine alone had minimal effect.
Topical combination of tea tree oil plus organically bound iodine cleared molluscum lesions in most children, whereas iodine alone had minimal effect.
Topical combination of tea tree oil plus organically bound iodine cleared molluscum lesions in most children, whereas iodine alone had minimal effect.
Treating mild iodine deficiency in pregnancy with potassium iodide (with or without T4) reduced maternal thyroid stimulation and normalized neonatal thyroid measures.
Treating mild iodine deficiency in pregnancy with potassium iodide (with or without T4) reduced maternal thyroid stimulation and normalized neonatal thyroid measures.
Treating mild iodine deficiency in pregnancy with potassium iodide (with or without T4) reduced maternal thyroid stimulation and normalized neonatal thyroid measures.
Radioiodine therapy increased oxidative stress markers; vitamin C given before therapy reduced some oxidative enzyme responses versus control.
Radioiodine therapy increased oxidative stress markers; vitamin C given before therapy reduced some oxidative enzyme responses versus control.
Radioiodine therapy increased oxidative stress markers; vitamin C given before therapy reduced some oxidative enzyme responses versus control.
Short-term high-dose iodine and iodide both raised TSH in healthy men; anticipated differential effects versus animal data were not observed.
Children eating salt fortified with multiple micronutrients including iodine for one year showed better micronutrient status and improvements on several memory and attention tests.
Children eating salt fortified with multiple micronutrients including iodine for one year showed better micronutrient status and improvements on several memory and attention tests.
Two weeks of inhaled salt–bromide–iodine thermal water modestly improved quality of life and reduced airway neutrophil percentage in COPD patients.
Two weeks of inhaled salt–bromide–iodine thermal water modestly improved quality of life and reduced airway neutrophil percentage in COPD patients.
Two weeks of inhaled salt–bromide–iodine thermal water modestly improved quality of life and reduced airway neutrophil percentage in COPD patients.
Single oral doses of iodized oil (200–800 mg iodine) normalized urinary iodine and thyroid hormones for about one year and reduced goiter in about two-thirds of adults.
Single oral doses of iodized oil (200–800 mg iodine) normalized urinary iodine and thyroid hormones for about one year and reduced goiter in about two-thirds of adults.
Adding lithium to radioiodine therapy increased cure rates and accelerated control of hyperthyroidism and enhanced goiter shrinkage.
Adding lithium to radioiodine therapy increased cure rates and accelerated control of hyperthyroidism and enhanced goiter shrinkage.
Adding lithium to radioiodine therapy increased cure rates and accelerated control of hyperthyroidism and enhanced goiter shrinkage.
Higher maternal urinary iodine in early pregnancy (below ~1 mg/L) was associated with modest increases in birth size measures in male newborns.
Higher maternal urinary iodine in early pregnancy (below ~1 mg/L) was associated with modest increases in birth size measures in male newborns.
Higher maternal urinary iodine in early pregnancy (below ~1 mg/L) was associated with modest increases in birth size measures in male newborns.
Four weeks of kelp supplementation increased urinary iodine dose-dependently and raised TSH (both low- and high-dose) with high-dose kelp lowering total T3 and augmenting TRH-stimulated TSH response.
Four weeks of kelp supplementation increased urinary iodine dose-dependently and raised TSH (both low- and high-dose) with high-dose kelp lowering total T3 and augmenting TRH-stimulated TSH response.
Radioiodine therapy produced large, dose-dependent reductions in thyroid volume, most of which occurred within six months and progressed by one year.
In patients receiving (131)I therapy for multinodular goiter, pre-treatment with 0.03 mg MRrhTSH increased thyroid volume reduction compared with placebo or 0.01 mg.
Low-dose rhTSH before a fixed radioiodine dose increased thyroid volume reduction compared with placebo in patients with multinodular goitre.
In iron-deficient goitrous children, adding iron improved iron status and made iodized salt more effective, reducing thyroid size and goiter rates.
In patients receiving (131)I therapy for multinodular goiter, pre-treatment with 0.03 mg MRrhTSH increased thyroid volume reduction compared with placebo or 0.01 mg.
In patients receiving (131)I therapy for multinodular goiter, pre-treatment with 0.03 mg MRrhTSH increased thyroid volume reduction compared with placebo or 0.01 mg.
Small randomized double-blind trial in Ecuador suggests 4–6 g/d seaweed (rich in iodine) may reduce systolic blood pressure and modestly reduce waist circumference in women.
Eating the iodine- and chromium-enriched Laminaria jam for 6 months led to larger weight loss, lower blood pressure, and better cholesterol than standard therapy.
Small randomized double-blind trial in Ecuador suggests 4–6 g/d seaweed (rich in iodine) may reduce systolic blood pressure and modestly reduce waist circumference in women.
Small randomized double-blind trial in Ecuador suggests 4–6 g/d seaweed (rich in iodine) may reduce systolic blood pressure and modestly reduce waist circumference in women.
Pilot randomized study: molecular iodine (5 mg/day) given with chemotherapy reduced some toxicities, increased tumor response rates, and was associated with longer disease‑free survival in breast cancer patients.
Pilot randomized study: molecular iodine (5 mg/day) given with chemotherapy reduced some toxicities, increased tumor response rates, and was associated with longer disease‑free survival in breast cancer patients.
Pilot randomized study: molecular iodine (5 mg/day) given with chemotherapy reduced some toxicities, increased tumor response rates, and was associated with longer disease‑free survival in breast cancer patients.
In moderately iodine‑deficient children, a single oral iodized oil dose improved iodine and thyroid status and produced significant gains on several cognitive and motor tests at 24 weeks.
In moderately iodine‑deficient children, a single oral iodized oil dose improved iodine and thyroid status and produced significant gains on several cognitive and motor tests at 24 weeks.
In moderately iodine-deficient Gambian women, prenatal MMN containing 300 μg iodine improved maternal iodine biomarkers during pregnancy and reduced maternal thyroglobulin, but had minimal impact on maternal thyroid hormones and limited postnatal benefit for breastmilk or infant iodine status.
Secondary analysis of an RCT in mildly iodine-deficient Thai pregnant women: daily 200 μg iodine raised maternal UIC but produced small declines in maternal thyroxine and no clear benefit on child cognitive outcomes (no significant benefit at 5.7 y; some borderline lower motor scores at 2 y).
Secondary analysis of an RCT in mildly iodine-deficient Thai pregnant women: daily 200 μg iodine raised maternal UIC but produced small declines in maternal thyroxine and no clear benefit on child cognitive outcomes (no significant benefit at 5.7 y; some borderline lower motor scores at 2 y).
Secondary analysis of an RCT in mildly iodine-deficient Thai pregnant women: daily 200 μg iodine raised maternal UIC but produced small declines in maternal thyroxine and no clear benefit on child cognitive outcomes (no significant benefit at 5.7 y; some borderline lower motor scores at 2 y).
Long-term follow-up of randomized low/intermediate-risk differentiated thyroid cancer patients receiving 1.1 vs 3.7 GBq radioactive iodine (RAI) ablation found no difference in long-term outcomes; excellent response in most patients.
Long-term follow-up of randomized low/intermediate-risk differentiated thyroid cancer patients receiving 1.1 vs 3.7 GBq radioactive iodine (RAI) ablation found no difference in long-term outcomes; excellent response in most patients.
Double-blind randomized trial in moderately iodine-deficient schoolchildren: Lipiodol increased urinary iodine but remained below normal and produced no short-term improvement in T4, TSH, weight, cognitive or motor tests at 4 months.
Daily 200 µg iodine in mildly iodine-deficient pregnant women showed no effect on child IQ or executive function at age 5-6 years.
Daily 200 µg iodine in mildly iodine-deficient pregnant women showed no effect on child IQ or executive function at age 5-6 years.
Daily 200 µg iodine in mildly iodine-deficient pregnant women showed no effect on child IQ or executive function at age 5-6 years.
In patients randomized after recurrence, radioiodine treatment resulted in higher rates of hypothyroidism and higher serum cholesterol/LDL compared with continued methimazole.
In patients randomized after recurrence, radioiodine treatment resulted in higher rates of hypothyroidism and higher serum cholesterol/LDL compared with continued methimazole.
In patients randomized after recurrence, radioiodine treatment resulted in higher rates of hypothyroidism and higher serum cholesterol/LDL compared with continued methimazole.
Quintuply-fortified salt (including iodine) did not alter gut microbiome alpha or beta diversity or relative abundance of measured taxa after 12 months compared with standard iodized salt.
Quintuply-fortified salt (including iodine) did not alter gut microbiome alpha or beta diversity or relative abundance of measured taxa after 12 months compared with standard iodized salt.
Quintuply-fortified salt (including iodine) did not alter gut microbiome alpha or beta diversity or relative abundance of measured taxa after 12 months compared with standard iodized salt.
Using iodine-125 seeds for preoperative lesion marking produced similar margin rates but significantly smaller surgical specimens compared with metallic clips.
Using iodine-125 seeds for preoperative lesion marking produced similar margin rates but significantly smaller surgical specimens compared with metallic clips.
A randomized trial testing different fixed radioiodine (I-131) doses found that doses ≥25 mCi achieved higher rates of remnant ablation than lower doses.
A randomized trial testing different fixed radioiodine (I-131) doses found that doses ≥25 mCi achieved higher rates of remnant ablation than lower doses.
In patients receiving radioiodine ablation, parotid gland massage reduced radioiodine retention in the gland; 1 minute of massage was as effective as 2 minutes.
In patients receiving radioiodine ablation, parotid gland massage reduced radioiodine retention in the gland; 1 minute of massage was as effective as 2 minutes.
A 12-week RCT in adolescents comparing fatty fish meals, meat meals, and n-3 supplements found increases in omega-3 biomarkers but no significant change in urinary iodine concentration between groups.
Randomized trial showing higher radioiodine activity (3.7 GBq) produced better lobe ablation than 1.1 GBq with no relevant side effects.
Randomized trial showing higher radioiodine activity (3.7 GBq) produced better lobe ablation than 1.1 GBq with no relevant side effects.
Single oral dose of iodized oil corrected iodine deficiency and reduced goiter prevalence in schoolchildren for over a year.
Randomized trial found no infectious events in either group and minimal differences in symptom scores; povidone-iodine suppository was safe.
In postmenopausal women, 7 weeks of seaweed (high iodine) raised urinary iodine and produced a small increase in TSH; soy had no effect.
In postmenopausal women, 7 weeks of seaweed (high iodine) raised urinary iodine and produced a small increase in TSH; soy had no effect.
Large cluster-randomized trial found no significant difference in surgical-site infection rates between iodine–alcohol and chlorhexidine–alcohol skin antiseptics.
Large cluster-randomized trial found no significant difference in surgical-site infection rates between iodine–alcohol and chlorhexidine–alcohol skin antiseptics.
Large cluster-randomized trial found no significant difference in surgical-site infection rates between iodine–alcohol and chlorhexidine–alcohol skin antiseptics.
In very low birth weight preterm infants, oral iodine supplementation corrected iodine status and affected thyroid hormones but did not change Bayley-III composite neurodevelopmental scores at 24 months.
In very low birth weight preterm infants, oral iodine supplementation corrected iodine status and affected thyroid hormones but did not change Bayley-III composite neurodevelopmental scores at 24 months.
In 110 patients, two contrast media with different iodine concentrations produced similar liver and vascular enhancement with no statistically significant differences.
In 110 patients, two contrast media with different iodine concentrations produced similar liver and vascular enhancement with no statistically significant differences.
Supplementing lactating women with 75 or 150 μg I/day raised maternal urinary iodine and breast-milk iodine but did not fully correct iodine deficiency in mothers or infants.
Supplementing lactating women with 75 or 150 μg I/day raised maternal urinary iodine and breast-milk iodine but did not fully correct iodine deficiency in mothers or infants.
Low-concentration (150 mg I/ml) contrast yielded lower diagnostic quality and confidence and fewer diagnostic exams (69% vs 96%) compared with 300 mg I/ml, but can be diagnostic in non-obese, normal cardiac-output patients.
Low-concentration (150 mg I/ml) contrast yielded lower diagnostic quality and confidence and fewer diagnostic exams (69% vs 96%) compared with 300 mg I/ml, but can be diagnostic in non-obese, normal cardiac-output patients.
Low-concentration (150 mg I/ml) contrast yielded lower diagnostic quality and confidence and fewer diagnostic exams (69% vs 96%) compared with 300 mg I/ml, but can be diagnostic in non-obese, normal cardiac-output patients.
Newborns of mothers who took prenatal iodine supplements had higher urinary iodine (+62%) and smaller thyroid volumes (−18%) compared with non-supplemented newborns; neonatal TSH remained normal.
Newborns of mothers who took prenatal iodine supplements had higher urinary iodine (+62%) and smaller thyroid volumes (−18%) compared with non-supplemented newborns; neonatal TSH remained normal.
Newborns of mothers who took prenatal iodine supplements had higher urinary iodine (+62%) and smaller thyroid volumes (−18%) compared with non-supplemented newborns; neonatal TSH remained normal.
Women evaluated taste/acceptability of salt fortified with iodine and other micronutrients; QFS was well accepted.
Women evaluated taste/acceptability of salt fortified with iodine and other micronutrients; QFS was well accepted.
Women evaluated taste/acceptability of salt fortified with iodine and other micronutrients; QFS was well accepted.
Randomized double-blind trial found iodine supplementation (150 µg) during pregnancy/postpartum did not increase postpartum thyroid dysfunction in TPO-Ab positive women.
Randomized double-blind trial found iodine supplementation (150 µg) during pregnancy/postpartum did not increase postpartum thyroid dysfunction in TPO-Ab positive women.
Randomized study comparing radioiodine, radioiodine+prednisone, and methimazole showed radioiodine increased risk of new/worsening ophthalmopathy unless prednisone was given.
Randomized study comparing radioiodine, radioiodine+prednisone, and methimazole showed radioiodine increased risk of new/worsening ophthalmopathy unless prednisone was given.
Single-blind prospective trial found pilocarpine did not reduce salivary complications after 131I therapy under the study's supportive measures.
Single-blind prospective trial found pilocarpine did not reduce salivary complications after 131I therapy under the study's supportive measures.
Reduced-iodine-dose dual-energy CT with low-energy virtual monochromatic images produced higher vascular attenuation and CNR than standard-iodine-dose single-energy CT.
Reduced-iodine-dose dual-energy CT with low-energy virtual monochromatic images produced higher vascular attenuation and CNR than standard-iodine-dose single-energy CT.
Tailoring iodine dose to both body weight and BMI removes the positive correlation between BMI and arterial attenuation seen when dosing by body weight alone.
Using 80 kVp plus iterative reconstruction allowed reduction of iodine contrast dose while maintaining or improving some image metrics and lowering radiation dose.
Reduced-iodine-dose dual-energy CT with low-energy virtual monochromatic images produced higher vascular attenuation and CNR than standard-iodine-dose single-energy CT.
Randomized study in 89 patients receiving 131I comparing vitamin E, vitamin C, and supragingival scaling with vitamin C; vitamin E protected parotid excretion function, and supragingival scaling with vitamin C improved uptake indices and excretion rates and attenuated serum amylase reduction.
Randomized study in 89 patients receiving 131I comparing vitamin E, vitamin C, and supragingival scaling with vitamin C; vitamin E protected parotid excretion function, and supragingival scaling with vitamin C improved uptake indices and excretion rates and attenuated serum amylase reduction.
Randomized study in 89 patients receiving 131I comparing vitamin E, vitamin C, and supragingival scaling with vitamin C; vitamin E protected parotid excretion function, and supragingival scaling with vitamin C improved uptake indices and excretion rates and attenuated serum amylase reduction.
Multicenter randomized trial comparing ROLLIS (iodine-125 seeds) to hookwire localization in breast conserving surgery; overall good cosmetic outcomes in both, with a higher proportion of good/excellent results in the ROLLIS group (82% vs 74%, P=0.02).
Multicenter randomized trial comparing ROLLIS (iodine-125 seeds) to hookwire localization in breast conserving surgery; overall good cosmetic outcomes in both, with a higher proportion of good/excellent results in the ROLLIS group (82% vs 74%, P=0.02).
Prospective randomized trial in 266 pregnant women comparing iodine supplementation versus none; neonatal median TSH was lower in the iodine group (3.44 vs 3.95 mIU/L, p<0.05) without clinical differences in neonatal outcomes.
Prospective randomized trial in 266 pregnant women comparing iodine supplementation versus none; neonatal median TSH was lower in the iodine group (3.44 vs 3.95 mIU/L, p<0.05) without clinical differences in neonatal outcomes.
Adding iodide to levothyroxine produced similar short-term thyroid hormone changes as levothyroxine alone.
Adding iodide to levothyroxine produced similar short-term thyroid hormone changes as levothyroxine alone.
Adding iodide to levothyroxine produced similar short-term thyroid hormone changes as levothyroxine alone.
Randomized clinical study in advanced NSCLC patients showing bronchial artery chemoembolization combined with 125I seed implantation improved remission rates, tumor markers, immune markers, and 6‑ and 12‑month survival versus 125I alone.
Randomized clinical study in advanced NSCLC patients showing bronchial artery chemoembolization combined with 125I seed implantation improved remission rates, tumor markers, immune markers, and 6‑ and 12‑month survival versus 125I alone.
Randomized clinical study in advanced NSCLC patients showing bronchial artery chemoembolization combined with 125I seed implantation improved remission rates, tumor markers, immune markers, and 6‑ and 12‑month survival versus 125I alone.
A flexible restricted-iodine diet lowered urinary iodine as effectively as a strict diet before radioiodine therapy.
A flexible restricted-iodine diet lowered urinary iodine as effectively as a strict diet before radioiodine therapy.
Higher iodine nutrition markers (e.g., serum iodine) were associated with greater risk of lateral lymph node metastasis; including iodine markers improved predictive model performance.
Higher iodine nutrition markers (e.g., serum iodine) were associated with greater risk of lateral lymph node metastasis; including iodine markers improved predictive model performance.
125I seed implantation improved tumor response, clinical benefit, and median survival versus control in unresectable pancreatic cancer.
125I seed implantation improved tumor response, clinical benefit, and median survival versus control in unresectable pancreatic cancer.
125I seed implantation improved tumor response, clinical benefit, and median survival versus control in unresectable pancreatic cancer.
Compared radioiodine (I-131) versus interstitial laser photocoagulation for hot thyroid nodules; radioiodine normalized TSH more often and reduced total thyroid volume more.
Compared radioiodine (I-131) versus interstitial laser photocoagulation for hot thyroid nodules; radioiodine normalized TSH more often and reduced total thyroid volume more.
Compared radioiodine (I-131) versus interstitial laser photocoagulation for hot thyroid nodules; radioiodine normalized TSH more often and reduced total thyroid volume more.
Compared irradiation stent (125I seeds) versus conventional stent for malignant biliary obstruction; irradiation stent relieved jaundice and extended survival and patency.
Compared irradiation stent (125I seeds) versus conventional stent for malignant biliary obstruction; irradiation stent relieved jaundice and extended survival and patency.
Randomized study of biliary stent ± I-125 seeds in malignant biliary obstruction: I-125 seeds increased stent patency and overall survival without added procedure complications.
Randomized comparison of four oral CT contrast agents; pasteurized whole milk provided best GI distension and tended to give better mural visualization than diluted iodine contrast, but milk had more GI adverse effects.
Randomized comparison of four oral CT contrast agents; pasteurized whole milk provided best GI distension and tended to give better mural visualization than diluted iodine contrast, but milk had more GI adverse effects.
Randomized comparison of four oral CT contrast agents; pasteurized whole milk provided best GI distension and tended to give better mural visualization than diluted iodine contrast, but milk had more GI adverse effects.
Compared low- and high-osmolality iodinated IV contrast agents for abdominal CT angiography; low-osmolality agent with higher iodine concentration provided longer aortic opacification.
Compared low- and high-osmolality iodinated IV contrast agents for abdominal CT angiography; low-osmolality agent with higher iodine concentration provided longer aortic opacification.
Preconception daily iodine-containing supplement (SQ-LNS, 250 μg iodine) raised maternal urinary iodine (I/Cr) at 12 weeks and was nominally associated with greater newborn length and head circumference.
Preconception daily iodine-containing supplement (SQ-LNS, 250 μg iodine) raised maternal urinary iodine (I/Cr) at 12 weeks and was nominally associated with greater newborn length and head circumference.
Preconception daily iodine-containing supplement (SQ-LNS, 250 μg iodine) raised maternal urinary iodine (I/Cr) at 12 weeks and was nominally associated with greater newborn length and head circumference.
Compared 125I-seed esophageal stent plus hyperbaric oxygen versus 125I stent alone; combination therapy produced higher local response rates and overall effective rate.
Compared artificial dermis + rb‑FGF versus standard povidone‑iodine gauze for residual infected burn wounds; artificial dermis + rb‑FGF showed better healing and bacterial clearance.
Compared 125I-seed esophageal stent plus hyperbaric oxygen versus 125I stent alone; combination therapy produced higher local response rates and overall effective rate.
Compared use of intraoperative hand-held gamma probe versus no probe for completion thyroidectomy; probe use associated with lower postoperative thyroglobulin, similar complication rates.
Compared use of intraoperative hand-held gamma probe versus no probe for completion thyroidectomy; probe use associated with lower postoperative thyroglobulin, similar complication rates.
Compared use of intraoperative hand-held gamma probe versus no probe for completion thyroidectomy; probe use associated with lower postoperative thyroglobulin, similar complication rates.
Topical tranexamic acid applied with povidone-iodine in knee replacement increased postoperative hemoglobin and tended to reduce blood loss without more complications.
Compared low- vs high-iodine contrast protocols in 100 patients undergoing aortic CT to assess image quality, radiation dose, and adverse effects.
Compared low- vs high-iodine contrast protocols in 100 patients undergoing aortic CT to assess image quality, radiation dose, and adverse effects.
Tailoring iodine dose to both body weight and BMI removes the positive correlation between BMI and arterial attenuation seen when dosing by body weight alone.
Pilot study of 36 pregnant/lactating women given 150 µg/day iodine from 20 weeks gestation; urinary and breast milk iodine measured.
Randomized comparison of contrast media at 300 vs 370 mg I/mL for 3D CT angiography of hepatic arteries; assessed visual quality and enhancement.
Randomized comparison of contrast media at 300 vs 370 mg I/mL for 3D CT angiography of hepatic arteries; assessed visual quality and enhancement.
Randomized comparison of contrast media at 300 vs 370 mg I/mL for 3D CT angiography of hepatic arteries; assessed visual quality and enhancement.
Double-blind RCT in Morocco comparing maternal oral iodised oil (400 mg) vs direct infant iodine supplementation to assess infant iodine status and thyroid function.
Double-blind RCT in Morocco comparing maternal oral iodised oil (400 mg) vs direct infant iodine supplementation to assess infant iodine status and thyroid function.
Population-based random sample (spot urine) measuring urinary iodine concentration across age groups in Bern region before planned salt iodization increase.
Population-based random sample (spot urine) measuring urinary iodine concentration across age groups in Bern region before planned salt iodization increase.
Postpartum iodine (50 or 250 µg) reduced thyroid size by 3 months and produced few mild transient thyroid dysfunctions.
Postpartum iodine (50 or 250 µg) reduced thyroid size by 3 months and produced few mild transient thyroid dysfunctions.
In cardiac CT patients, an iodine injection rate of ~1 g iodine/s provided optimal vascular contrast enhancement.
In cardiac CT patients, an iodine injection rate of ~1 g iodine/s provided optimal vascular contrast enhancement.
In cardiac CT patients, an iodine injection rate of ~1 g iodine/s provided optimal vascular contrast enhancement.
8-week oral iodinated activated charcoal modestly improved baseline FEV1 in moderate COPD versus placebo.
8-week oral iodinated activated charcoal modestly improved baseline FEV1 in moderate COPD versus placebo.
High cumulative I-131 (≥11.1 GBq) was associated with higher rates of nasolacrimal duct obstruction.
High cumulative I-131 (≥11.1 GBq) was associated with higher rates of nasolacrimal duct obstruction.
High cumulative I-131 (≥11.1 GBq) was associated with higher rates of nasolacrimal duct obstruction.
After radioiodine therapy, ~9.8% had GO exacerbation; low-dose prophylactic corticosteroid (15 mg) did not significantly prevent exacerbation.
After radioiodine therapy, ~9.8% had GO exacerbation; low-dose prophylactic corticosteroid (15 mg) did not significantly prevent exacerbation.
After radioiodine therapy, ~9.8% had GO exacerbation; low-dose prophylactic corticosteroid (15 mg) did not significantly prevent exacerbation.
Randomized trial in 82 thyroid cancer patients receiving 100 mCi radioiodine; vitamin E (100–300 mg/day) around therapy preserved salivary gland function on scintigraphy compared with control.
Randomized trial in 82 thyroid cancer patients receiving 100 mCi radioiodine; vitamin E (100–300 mg/day) around therapy preserved salivary gland function on scintigraphy compared with control.
Randomized trial in 82 thyroid cancer patients receiving 100 mCi radioiodine; vitamin E (100–300 mg/day) around therapy preserved salivary gland function on scintigraphy compared with control.
Retrospective cohort (N=854) developing machine-learning models to predict response to 131I therapy and TSH suppression; stimulated/suppressed thyroglobulin and radioiodine uptake were top predictors; RF models achieved high AUCs.
Retrospective cohort (N=854) developing machine-learning models to predict response to 131I therapy and TSH suppression; stimulated/suppressed thyroglobulin and radioiodine uptake were top predictors; RF models achieved high AUCs.
Retrospective cohort (N=854) developing machine-learning models to predict response to 131I therapy and TSH suppression; stimulated/suppressed thyroglobulin and radioiodine uptake were top predictors; RF models achieved high AUCs.
Randomized controlled trial (n=204) testing assistant distance countdown during Lugol chromoendoscopy; countdown markedly reduced iodine reflux and multiple post-procedure adverse events.
Randomized controlled trial (n=204) testing assistant distance countdown during Lugol chromoendoscopy; countdown markedly reduced iodine reflux and multiple post-procedure adverse events.
Randomized controlled trial (n=204) testing assistant distance countdown during Lugol chromoendoscopy; countdown markedly reduced iodine reflux and multiple post-procedure adverse events.
Randomized double-blind trial in women with cyclic breast pain: molecular iodine (3.0 and 6.0 mg/day) reduced breast pain and related findings versus placebo.
Randomized double-blind trial in women with cyclic breast pain: molecular iodine (3.0 and 6.0 mg/day) reduced breast pain and related findings versus placebo.
Short clinical study in HCV patients: excess iodine (with or without rIFN-alpha) caused small changes in thyroid function over 2 months.
Healthy adults given 100–300 μg iodide daily for 6 months showed no meaningful change in thyroid function but had slight anti-inflammatory/antioxidant marker changes.
Screened elderly Chinese for thyroid problems; found thyroid dysfunction mainly in women, with possible contributions from autoimmunity and borderline iodine intake.
Short clinical study in HCV patients: excess iodine (with or without rIFN-alpha) caused small changes in thyroid function over 2 months.
Screened elderly Chinese for thyroid problems; found thyroid dysfunction mainly in women, with possible contributions from autoimmunity and borderline iodine intake.
Blinded randomized tasting study: iodine-based disinfectant (TGHP) worsened water taste, but adding ascorbic acid restored palatability to near plain water.
Blinded randomized tasting study: iodine-based disinfectant (TGHP) worsened water taste, but adding ascorbic acid restored palatability to near plain water.
Study of prostate brachytherapy (I-125): short-term urinary symptoms peaked at 1 month; high intraprostatic dose volumes did not predict 12-month urinary or rectal morbidity.
Study of prostate brachytherapy (I-125): short-term urinary symptoms peaked at 1 month; high intraprostatic dose volumes did not predict 12-month urinary or rectal morbidity.
Large prospective cohort from a randomized trial: I-125 brachytherapy led to high cataract incidence by 5 years and cataract surgery usually improved vision.
Large prospective cohort from a randomized trial: I-125 brachytherapy led to high cataract incidence by 5 years and cataract surgery usually improved vision.
Adding intraoperative iodine-125 seed implantation to surgery reduced local recurrence and improved longer-term survival in advanced esophageal squamous cell carcinoma.
A single postoperative intra-arterial 131I‑lipiodol dose after liver cancer resection reduced local recurrence and improved disease-free and overall survival versus no adjuvant treatment.
Adding intraoperative iodine-125 seed implantation to surgery reduced local recurrence and improved longer-term survival in advanced esophageal squamous cell carcinoma.
Adding I-125 seed brachytherapy to sphincter-preserving surgery reduced local recurrences and improved 3-year survival and some functional outcomes.
Adding intraoperative iodine-125 seed implantation to surgery reduced local recurrence and improved longer-term survival in advanced esophageal squamous cell carcinoma.
Adding intraoperative iodine-125 seed implantation to surgery reduced local recurrence and improved longer-term survival in advanced esophageal squamous cell carcinoma.
Many schoolchildren had clinical goitre despite biochemical measures reported as indicating adequate environmental iodine and most household salt having recommended iodine levels.
A single oral iodised-oil dose increased urinary iodine and markedly reduced goitre prevalence at 40 weeks; efficacy was lower in children with poorer weight-for-height.
Many schoolchildren had clinical goitre despite biochemical measures reported as indicating adequate environmental iodine and most household salt having recommended iodine levels.
Many schoolchildren had clinical goitre despite biochemical measures reported as indicating adequate environmental iodine and most household salt having recommended iodine levels.
Assessed whether povidone-iodine skin prep affects infants' thyroid hormones after cardiac surgery; cardiopulmonary bypass had larger effects than antiseptic used.
Short-term iodine supplementation raised urinary iodine and TSH; higher supplement doses led to reduced thyroid volume at the highest doses and caused subclinical hypothyroidism at and above certain intake levels.
Short-term iodine supplementation raised urinary iodine and TSH; higher supplement doses led to reduced thyroid volume at the highest doses and caused subclinical hypothyroidism at and above certain intake levels.
EUS-guided iodine-125 brachytherapy achieved high complete response rates and better tumor control than ethanol ablation for selected refractory left-sided liver tumors, with a good safety profile.
EUS-guided iodine-125 brachytherapy achieved high complete response rates and better tumor control than ethanol ablation for selected refractory left-sided liver tumors, with a good safety profile.
Using a higher iodine concentration contrast (370 mg I/mL) at fixed volume and rate improved detection sensitivity and diagnostic accuracy for hypervascular hepatocellular carcinomas on MDCT compared with 300 mg I/mL.
Using a higher iodine concentration contrast (370 mg I/mL) at fixed volume and rate improved detection sensitivity and diagnostic accuracy for hypervascular hepatocellular carcinomas on MDCT compared with 300 mg I/mL.
In patients with Hashimoto's thyroiditis, daily 250 μg potassium iodide led to thyroid dysfunction in a minority: several developed subclinical or overt hypothyroidism that in some cases reversed after stopping iodine.
In patients with Hashimoto's thyroiditis, daily 250 μg potassium iodide led to thyroid dysfunction in a minority: several developed subclinical or overt hypothyroidism that in some cases reversed after stopping iodine.
In patients with Hashimoto's thyroiditis, daily 250 μg potassium iodide led to thyroid dysfunction in a minority: several developed subclinical or overt hypothyroidism that in some cases reversed after stopping iodine.
In patients given high-dose I-131, vitamin E around treatment appeared to protect salivary gland function compared with placebo.
In nontoxic nodular goiter, 131I therapy reduced goiter size substantially more than suppressive levothyroxine but caused more hypothyroidism; levothyroxine caused bone loss.
In nontoxic nodular goiter, 131I therapy reduced goiter size substantially more than suppressive levothyroxine but caused more hypothyroidism; levothyroxine caused bone loss.
Thyroid ultrasound echogenicity and gland size predict response to radioiodine in Graves' disease: normoechogenic and large glands are more radioresistant.
Thyroid ultrasound echogenicity and gland size predict response to radioiodine in Graves' disease: normoechogenic and large glands are more radioresistant.
Placing an iodine-containing tampon into the extraction socket after wisdom tooth removal reduced pain and improved oral health–related quality of life in the first postoperative week.
Placing an iodine-containing tampon into the extraction socket after wisdom tooth removal reduced pain and improved oral health–related quality of life in the first postoperative week.
Placing an iodine-containing tampon into the extraction socket after wisdom tooth removal reduced pain and improved oral health–related quality of life in the first postoperative week.
Randomized trial in patients with Graves' disease comparing drugs, surgery, or radioactive iodine; thyroid hormones normalized quickly and relapse rates differed by treatment.
Randomized trial in patients with Graves' disease comparing drugs, surgery, or radioactive iodine; thyroid hormones normalized quickly and relapse rates differed by treatment.
Randomized trial in patients with Graves' disease comparing drugs, surgery, or radioactive iodine; thyroid hormones normalized quickly and relapse rates differed by treatment.
Randomized trial comparing four empirical 131I doses for thyroid remnant ablation; ablation rates improved up to ~50 mCi and plateaued at higher doses.
Randomized trial comparing four empirical 131I doses for thyroid remnant ablation; ablation rates improved up to ~50 mCi and plateaued at higher doses.
Cluster randomized community trial where behavior-change intervention to promote iodized salt increased children's urinary iodine and was associated with improved growth (reduced stunting and greater height gains).
Cluster randomized community trial where behavior-change intervention to promote iodized salt increased children's urinary iodine and was associated with improved growth (reduced stunting and greater height gains).
Cluster randomized community trial where behavior-change intervention to promote iodized salt increased children's urinary iodine and was associated with improved growth (reduced stunting and greater height gains).
Among 103 university staff, 24-h urinary measures showed median UIC consistent with mild iodine deficiency and estimated intake below recommended levels; household salt often had low iodine.
Among 103 university staff, 24-h urinary measures showed median UIC consistent with mild iodine deficiency and estimated intake below recommended levels; household salt often had low iodine.
Among 103 university staff, 24-h urinary measures showed median UIC consistent with mild iodine deficiency and estimated intake below recommended levels; household salt often had low iodine.
In 92 Graves' patients randomized to three I-131 dosing strategies, higher fixed doses increased cure rates but also produced larger increases in ophthalmopathy (proptosis and CAS); a calculated dose balanced efficacy and fewer eye complications.
In 92 Graves' patients randomized to three I-131 dosing strategies, higher fixed doses increased cure rates but also produced larger increases in ophthalmopathy (proptosis and CAS); a calculated dose balanced efficacy and fewer eye complications.
In patients receiving radioiodine for Graves' disease, pretreatment with methimazole did not change final cure rates or time to hypothyroidism compared with no pretreatment.
In patients receiving radioiodine for Graves' disease, pretreatment with methimazole did not change final cure rates or time to hypothyroidism compared with no pretreatment.
In ICU patients, a catheter hub containing 3% iodinated alcohol markedly reduced hub colonization and catheter-related bloodstream infections compared with standard connectors.
In ICU patients, a catheter hub containing 3% iodinated alcohol markedly reduced hub colonization and catheter-related bloodstream infections compared with standard connectors.
In ICU patients, a catheter hub containing 3% iodinated alcohol markedly reduced hub colonization and catheter-related bloodstream infections compared with standard connectors.
Many postpartum Colombian mothers had high TSH; salt restriction was associated with higher TSH and levels fell by 14 days and term.
Many postpartum Colombian mothers had high TSH; salt restriction was associated with higher TSH and levels fell by 14 days and term.
Many postpartum Colombian mothers had high TSH; salt restriction was associated with higher TSH and levels fell by 14 days and term.
In CT imaging, higher iodine mass produced greater liver enhancement; estimated 0.28 gI/kg yields a 50-HU increase.
In CT imaging, higher iodine mass produced greater liver enhancement; estimated 0.28 gI/kg yields a 50-HU increase.
Thyroid hormone withdrawal caused a significant drop in GFR (~18–22%), while rhTSH stimulation preserved GFR.
Thyroid hormone withdrawal caused a significant drop in GFR (~18–22%), while rhTSH stimulation preserved GFR.
Radioiodine (131I) increased genotoxic markers (micronuclei and clastogenic factors) in placebo patients; Ginkgo biloba prevented these increases.
Radioiodine (131I) increased genotoxic markers (micronuclei and clastogenic factors) in placebo patients; Ginkgo biloba prevented these increases.
Parotid gland massage reduced salivary gland radioisotope accumulation and may help prevent salivary damage from radioiodine therapy.
Parotid gland massage reduced salivary gland radioisotope accumulation and may help prevent salivary damage from radioiodine therapy.
Weight-adapted low-kVp CT protocols maintain image quality and allow substantial reduction in iodine contrast dose (>50% in lighter patients).
Weight-adapted low-kVp CT protocols maintain image quality and allow substantial reduction in iodine contrast dose (>50% in lighter patients).
Compared two iodinated contrast agents; iodixanol caused less discomfort and had similar diagnostic efficacy with differing short-term renal enzyme and creatinine effects.
Compared two iodinated contrast agents; iodixanol caused less discomfort and had similar diagnostic efficacy with differing short-term renal enzyme and creatinine effects.
Compared two iodinated contrast agents; iodixanol caused less discomfort and had similar diagnostic efficacy with differing short-term renal enzyme and creatinine effects.
Radioiodine reduced thyroid volume substantially; adjunct lithium prevented early radioiodine-induced hyperthyroidism.
Iodine administration normalized thyroid tests and improved growth; adding selenium did not alter established disease outcomes at 12 months.
Iodine administration normalized thyroid tests and improved growth; adding selenium did not alter established disease outcomes at 12 months.
Compared two radioisotopes for prostate brachytherapy; Pd-103 gave quicker recovery and lower early urinary symptom scores than I-125.
Randomized trial comparing I-125 and Pd-103 seeds for prostate brachytherapy found differences in early and mid-term urinary and rectal side effects: Pd-103 produced worse urinary symptoms early but recovered sooner; I-125 showed a trend toward more rectal bleeding.
Compared two radioisotopes for prostate brachytherapy; Pd-103 gave quicker recovery and lower early urinary symptom scores than I-125.
Higher iodine concentration (≥300 mg/ml) produced superior aortic and porto-venous hepatic enhancement; lower concentrations risk insufficient hepatic porto-venous enhancement.
Higher iodine concentration (≥300 mg/ml) produced superior aortic and porto-venous hepatic enhancement; lower concentrations risk insufficient hepatic porto-venous enhancement.
Patients with hyperthyroidism randomized to iodated vs non-iodated salt; antithyroid drug needs were tracked over 6 months.
Prospective comparison of 80 kVp with moderate-concentration iodinated contrast vs 120 kVp with high-concentration contrast for renal CTA in 50 patients.
Randomized volunteer study showing 70-kVp CT angiography improves vascular enhancement and image quality and allows reduced iodine contrast volume and lower radiation dose.
Randomized trial showing low-concentration contrast with low tube voltage + iterative reconstruction reduces radiation dose while maintaining or improving vascular attenuation and image quality.
Prospective comparison of 80 kVp with moderate-concentration iodinated contrast vs 120 kVp with high-concentration contrast for renal CTA in 50 patients.
Randomized trial comparing I-125–seed radioactive stent vs conventional stent for malignant airway obstruction; restenosis, survival, and complications assessed.
Stents loaded with 125I seeds prolonged median overall survival compared with conventional stents in unresectable oesophageal cancer.
CT-guided permanent 125I seed implantation improved local tumor control and resulted in longer survival compared with radiochemotherapy for pelvic recurrence after cervical cancer surgery.
Randomized trial comparing I-125–seed radioactive stent vs conventional stent for malignant airway obstruction; restenosis, survival, and complications assessed.
Randomized trial comparing I-125–seed radioactive stent vs conventional stent for malignant airway obstruction; restenosis, survival, and complications assessed.
Open randomized trial comparing I-125 seed interstitial brachytherapy vs local chemotherapy perfusion in advanced pancreatic cancer patients; tumor response, pain, tumor markers, and survival assessed.
Compared a new topical dressing to Alvogyl (which contains iodoform); new dressing gave faster short-term pain relief (30–60 min) but Alvogyl provided better pain control at 24–72 hours; no complications.
Open randomized trial comparing I-125 seed interstitial brachytherapy vs local chemotherapy perfusion in advanced pancreatic cancer patients; tumor response, pain, tumor markers, and survival assessed.
Randomized trial comparing Alvogyl (contains iodoform) versus black seed mixture and saline for dry socket; black seed produced fastest pain relief and Alvogyl improved pain gradually.
Open randomized trial comparing I-125 seed interstitial brachytherapy vs local chemotherapy perfusion in advanced pancreatic cancer patients; tumor response, pain, tumor markers, and survival assessed.
Open randomized trial comparing I-125 seed interstitial brachytherapy vs local chemotherapy perfusion in advanced pancreatic cancer patients; tumor response, pain, tumor markers, and survival assessed.
Randomized trial comparing I-125 vs Cs-131 isotopes for prostate brachytherapy with long-term follow-up (~97 months); urinary, sexual, bowel QOL and biochemical relapse assessed.
Randomized trial comparing I-125 vs Cs-131 isotopes for prostate brachytherapy with long-term follow-up (~97 months); urinary, sexual, bowel QOL and biochemical relapse assessed.
Randomized trial comparing I-125 vs Cs-131 isotopes for prostate brachytherapy with long-term follow-up (~97 months); urinary, sexual, bowel QOL and biochemical relapse assessed.
Double-blind RCT in older adults testing selenium, iodine, their combination, or placebo for 3 months; thyroid function, thyroglobulin, selenium status and urinary iodine measured.
Pregnant women randomized to iodised salt or iodine supplements showed no difference in child neurodevelopment; prior long-term iodised salt use raised maternal urinary iodine and reduced thyroid volume.
Pregnant women randomized to iodised salt or iodine supplements showed no difference in child neurodevelopment; prior long-term iodised salt use raised maternal urinary iodine and reduced thyroid volume.
Children with ASD who received iodine-bromine baths showed biochemical changes in stress hormones and reported calming effects in those with severe hyperactivity.
Children with ASD who received iodine-bromine baths showed biochemical changes in stress hormones and reported calming effects in those with severe hyperactivity.
Children with ASD who received iodine-bromine baths showed biochemical changes in stress hormones and reported calming effects in those with severe hyperactivity.
In 460 untreated hyperthyroid patients followed ~9 years, radioiodine (131I) produced higher cure rates and lower recurrence but more hypothyroidism versus antithyroid drugs.
In 460 untreated hyperthyroid patients followed ~9 years, radioiodine (131I) produced higher cure rates and lower recurrence but more hypothyroidism versus antithyroid drugs.
Randomized, double-masked trial in 617 Indonesian infants showed oral iodized oil given ~6 weeks of age reduced early infant deaths and delayed time to death among those who died.
Randomized, double-masked trial in 617 Indonesian infants showed oral iodized oil given ~6 weeks of age reduced early infant deaths and delayed time to death among those who died.
In 752 thyroid cancer patients, recombinant TSH (rhTSH) avoided the transient HRQoL deterioration caused by thyroid hormone withdrawal (THW) around 131I administration but at higher cost.
In 752 thyroid cancer patients, recombinant TSH (rhTSH) avoided the transient HRQoL deterioration caused by thyroid hormone withdrawal (THW) around 131I administration but at higher cost.
In 752 thyroid cancer patients, recombinant TSH (rhTSH) avoided the transient HRQoL deterioration caused by thyroid hormone withdrawal (THW) around 131I administration but at higher cost.
Single-blinded randomized trial in 57 completers with Graves' disease found similar 6-month outcomes for 60 Gy versus 90 Gy radioiodine dosing, with notable rates of hypothyroidism and nonresponse.
Single-blinded randomized trial in 57 completers with Graves' disease found similar 6-month outcomes for 60 Gy versus 90 Gy radioiodine dosing, with notable rates of hypothyroidism and nonresponse.
Single-blinded randomized trial in 57 completers with Graves' disease found similar 6-month outcomes for 60 Gy versus 90 Gy radioiodine dosing, with notable rates of hypothyroidism and nonresponse.
In 69 postoperative thyroid cancer patients receiving 131I, antioxidant regimens (vitamin E+C, selenium, selenium+C) were associated with improved salivary gland function parameters one month after treatment.
In 69 postoperative thyroid cancer patients receiving 131I, antioxidant regimens (vitamin E+C, selenium, selenium+C) were associated with improved salivary gland function parameters one month after treatment.
In 69 postoperative thyroid cancer patients receiving 131I, antioxidant regimens (vitamin E+C, selenium, selenium+C) were associated with improved salivary gland function parameters one month after treatment.
In 110 iodine-deficient schoolchildren, treating intestinal parasites before oral iodized oil substantially prolonged the duration of urinary iodine protection compared with untreated children.
In 110 iodine-deficient schoolchildren, treating intestinal parasites before oral iodized oil substantially prolonged the duration of urinary iodine protection compared with untreated children.
Measured iodine in diet, water and salt of schoolchildren and found intake above recommended but below the upper limit.
Measured iodine in diet, water and salt of schoolchildren and found intake above recommended but below the upper limit.
Randomized comparison of two levothyroxine+iodide dose combos showed both reduced goitre size similarly with different TSH responses.
Randomized comparison of two levothyroxine+iodide dose combos showed both reduced goitre size similarly with different TSH responses.
Giving short-course methimazole before 131I increased radioiodine uptake and sped goitre shrinkage compared with placebo+131I.
Giving short-course methimazole before 131I increased radioiodine uptake and sped goitre shrinkage compared with placebo+131I.
Giving short-course methimazole before 131I increased radioiodine uptake and sped goitre shrinkage compared with placebo+131I.
In patients with advanced esophageal cancer, stents loaded with 125I seeds provided slightly longer dysphagia relief and improved survival versus covered stents.
In patients with advanced esophageal cancer, stents loaded with 125I seeds provided slightly longer dysphagia relief and improved survival versus covered stents.
In patients with advanced esophageal cancer, stents loaded with 125I seeds provided slightly longer dysphagia relief and improved survival versus covered stents.
In iron-deficient adolescent girls, improving iron status (with or without added iodine) improved some thyroid hormone indices; iodine alone increased urinary iodine but not thyroid indices.
In iron-deficient adolescent girls, improving iron status (with or without added iodine) improved some thyroid hormone indices; iodine alone increased urinary iodine but not thyroid indices.
In iron-deficient adolescent girls, improving iron status (with or without added iodine) improved some thyroid hormone indices; iodine alone increased urinary iodine but not thyroid indices.
Compared dosimetric coverage and uniformity between HDR brachytherapy and permanent iodine-125 prostate implants; HDR provided better coverage and homogeneity.
Compared dosimetric coverage and uniformity between HDR brachytherapy and permanent iodine-125 prostate implants; HDR provided better coverage and homogeneity.
Compared dosimetric coverage and uniformity between HDR brachytherapy and permanent iodine-125 prostate implants; HDR provided better coverage and homogeneity.
Large randomized crossover study comparing skin antisepsis with chlorhexidine versus iodine tincture for blood cultures; found no difference in contamination rates.
Prospective randomized study of radioiodine dosing for Graves' disease showing success rates depend on dose and thyroid volume.
Prospective randomized study of radioiodine dosing for Graves' disease showing success rates depend on dose and thyroid volume.
Prospective randomized study of radioiodine dosing for Graves' disease showing success rates depend on dose and thyroid volume.
Randomized comparison of contrast concentration/volume protocols showing that reducing iodine dose lowers hepatic contrast enhancement and may reduce lesion detectability.
Randomized comparison of contrast concentration/volume protocols showing that reducing iodine dose lowers hepatic contrast enhancement and may reduce lesion detectability.
Randomized comparison of contrast concentration/volume protocols showing that reducing iodine dose lowers hepatic contrast enhancement and may reduce lesion detectability.
Prospective study testing two fixed-time iodine injection protocols for triple‑rule‑out chest CT showing protocol differences by BMI groups with no radiation dose penalty.
Prospective study testing two fixed-time iodine injection protocols for triple‑rule‑out chest CT showing protocol differences by BMI groups with no radiation dose penalty.
Prospective study testing two fixed-time iodine injection protocols for triple‑rule‑out chest CT showing protocol differences by BMI groups with no radiation dose penalty.
Randomized trial comparing two iodine contrast concentrations (300 vs 370 mg/mL) showing higher concentration yields greater hepatic and vascular enhancement on multiphasic CT.
Randomized trial comparing two iodine contrast concentrations (300 vs 370 mg/mL) showing higher concentration yields greater hepatic and vascular enhancement on multiphasic CT.
Randomized trial comparing two iodine contrast concentrations (300 vs 370 mg/mL) showing higher concentration yields greater hepatic and vascular enhancement on multiphasic CT.
Randomized trial showing low-concentration contrast with low tube voltage + iterative reconstruction reduces radiation dose while maintaining or improving vascular attenuation and image quality.
Randomized trial showing low-concentration contrast with low tube voltage + iterative reconstruction reduces radiation dose while maintaining or improving vascular attenuation and image quality.
Individualized iodine-contrast injection based on body mass gave similar image quality while reducing contrast volume.
Individualized iodine-contrast injection based on body mass gave similar image quality while reducing contrast volume.
Individualized iodine-contrast injection based on body mass gave similar image quality while reducing contrast volume.
A nutrition intervention increased women's weight, BMI and use of iodized salt in a large sample of destitute women.
Four-week randomized diet trial in women showing the Paleolithic diet led to greater short-term weight and fat loss and reduced dietary calcium intake compared to guidelines-based diet.
In a small randomized subsample, an 8-week whole-food plant-based diet reduced weight, HbA1c and several cardiometabolic risk factors but decreased intake of some micronutrients including vitamin D and calcium.
A nutrition intervention increased women's weight, BMI and use of iodized salt in a large sample of destitute women.
A nutrition intervention increased women's weight, BMI and use of iodized salt in a large sample of destitute women.
Among CT patients, overall acute adverse reactions were low and similar between moderate- and high-iodine concentration contrast; heat sensation was higher with high concentration.
Randomized trial comparing high (400 mg/ml) vs lower (300 mg/ml) iodinated contrast concentrations; overall patient-reported discomfort was very low with only a small difference in pain favoring lower concentration.
Among CT patients, overall acute adverse reactions were low and similar between moderate- and high-iodine concentration contrast; heat sensation was higher with high concentration.
Low-dose rhTSH before a fixed radioiodine dose increased thyroid volume reduction compared with placebo in patients with multinodular goitre.
Randomized CT angiography study comparing two iodine-containing contrast regimens; arterial image quality similar but lower venous enhancement with lower-volume, higher-concentration contrast.
Tailoring iodine dose to both body weight and BMI removes the positive correlation between BMI and arterial attenuation seen when dosing by body weight alone.
Randomized CT angiography study comparing two iodine-containing contrast regimens; arterial image quality similar but lower venous enhancement with lower-volume, higher-concentration contrast.
Randomized volunteer study showing 70-kVp CT angiography improves vascular enhancement and image quality and allows reduced iodine contrast volume and lower radiation dose.
Prospective randomized study in normal-weight patients showing CCTA at 70 kVp with 28 mL iodinated contrast and low injection rate produced diagnostic image quality similar to standard protocol (40 mL).
Randomized volunteer study showing 70-kVp CT angiography improves vascular enhancement and image quality and allows reduced iodine contrast volume and lower radiation dose.
Pilot randomized CTA study showing dual-energy CT allows up to ~60% iodinated contrast volume reduction without loss of image quality.
Randomized trial showing dual-energy CT allowed >50% reduction in iodinated contrast volume (35 mL vs 80 mL) with comparable diagnostic interpretability and similar CNR/SNR after adjustment.
Randomized imaging study showing saline flushing with contrast increases liver and portal vein peak enhancement and that reducing contrast plus flush shortens the optimal imaging window.
Randomized imaging study showing saline flushing with contrast increases liver and portal vein peak enhancement and that reducing contrast plus flush shortens the optimal imaging window.
Randomized imaging study showing saline flushing with contrast increases liver and portal vein peak enhancement and that reducing contrast plus flush shortens the optimal imaging window.
Randomized double-blind trial showing rhTSH given 24 h before radioiodine produces the largest increase in thyroid radioactive iodine uptake compared with longer intervals.
Randomized double-blind trial showing rhTSH given 24 h before radioiodine produces the largest increase in thyroid radioactive iodine uptake compared with longer intervals.
Randomized double-blind trial showing rhTSH given 24 h before radioiodine produces the largest increase in thyroid radioactive iodine uptake compared with longer intervals.
Randomized comparison of topical minocycline, metronidazole, and iodine glycerin for periodontitis; all improved but iodine glycerin was less effective than the antibiotics.
Randomized comparison of topical minocycline, metronidazole, and iodine glycerin for periodontitis; all improved but iodine glycerin was less effective than the antibiotics.
In preterm infants, iodine-containing contrast increased urinary iodine and improved PICC tip visualization but did not alter subsequent thyroid function (TSH).
In preterm infants, iodine-containing contrast increased urinary iodine and improved PICC tip visualization but did not alter subsequent thyroid function (TSH).
Healthy adults given 100–300 μg iodide daily for 6 months showed no meaningful change in thyroid function but had slight anti-inflammatory/antioxidant marker changes.
Healthy adults given 100–300 μg iodide daily for 6 months showed no meaningful change in thyroid function but had slight anti-inflammatory/antioxidant marker changes.
Compared daily povidone-iodine site care with an occlusive dressing for short-term CVCs and found no significant difference in catheter infection rates.
Compared daily povidone-iodine site care with an occlusive dressing for short-term CVCs and found no significant difference in catheter infection rates.
Randomized study in 60 laboring women comparing povidone iodine (PI) versus DuraPrep (iodophor in isopropyl alcohol) for skin antisepsis before epidural catheter insertion, assessing skin cultures and catheter colonization.
No difference found between 10% povidone-iodine and 0.5% chlorhexidine ethanol in catheter site or tip colonization for short-term epidural catheters.
In neonates requiring central venous catheters, skin disinfection with 10% povidone-iodine was as effective as a chlorhexidine-impregnated dressing for preventing bloodstream infections, but had higher catheter-tip colonization and no contact dermatitis.
Compared daily povidone-iodine site care with an occlusive dressing for short-term CVCs and found no significant difference in catheter infection rates.
In thyroid remnant ablation, rhTSH led to longer remnant radioactive-iodine half-life but shorter whole-body residence times and lower absorbed doses to several non-thyroid organs versus thyroid hormone withdrawal.
In thyroid remnant ablation, rhTSH led to longer remnant radioactive-iodine half-life but shorter whole-body residence times and lower absorbed doses to several non-thyroid organs versus thyroid hormone withdrawal.
In thyroid remnant ablation, rhTSH led to longer remnant radioactive-iodine half-life but shorter whole-body residence times and lower absorbed doses to several non-thyroid organs versus thyroid hormone withdrawal.
Schoolchildren with moderate iodine deficiency had higher oxidative stress markers and lower antioxidant capacity than children with mild deficiency or iodine sufficiency.
Schoolchildren with moderate iodine deficiency had higher oxidative stress markers and lower antioxidant capacity than children with mild deficiency or iodine sufficiency.
Schoolchildren with moderate iodine deficiency had higher oxidative stress markers and lower antioxidant capacity than children with mild deficiency or iodine sufficiency.
Report of multinational treatment experience using radioiodine ablation for differentiated thyroid cancer with generally good outcomes.
Report of multinational treatment experience using radioiodine ablation for differentiated thyroid cancer with generally good outcomes.
Using rhTSH instead of hypothyroidism to prepare for radioiodine ablation preserved quality of life with similar ablation success.
Higher therapeutic I-131 dose (3700 MBq) produced more successful removal of residual thyroid tissue than a lower dose (1110 MBq).
Using rhTSH instead of hypothyroidism to prepare for radioiodine ablation preserved quality of life with similar ablation success.
A higher I-131 dose (100 mCi) achieved higher ablation success than 50 mCi in this small randomized trial.
In patients with differentiated thyroid cancer and low preablative thyroglobulin, low-dose radioiodine produced similar ablation rates to high-dose with no recurrences during short follow-up.
rhTSH preserves quality of life compared with thyroid-hormone withdrawal while achieving comparable low-dose radioiodine remnant ablation success rates.
Randomized trial comparing low (1.1 GBq) vs high (3.7 GBq) 131I doses in low/intermediate-risk thyroid cancer: ablation and therapeutic responses similar, but fewer adverse reactions with low dose.
Using rhTSH instead of hypothyroidism to prepare for radioiodine ablation preserved quality of life with similar ablation success.
In repeat CIED procedures, using an iodine-impregnated adhesive drape reduced pocket contamination and subsequent device infections.
In repeat CIED procedures, using an iodine-impregnated adhesive drape reduced pocket contamination and subsequent device infections.
Adding iodine-131 to levothyroxine after thyroid cancer surgery improved response rate and reduced one-year recurrence without increasing side effects.
Adding iodine-131 to levothyroxine after thyroid cancer surgery improved response rate and reduced one-year recurrence without increasing side effects.
Adolescents with endemic goitre given iodine alone or iodine+levothyroxine both corrected deficiency and reduced thyroid volume and lipids, with greater volume reduction in the combination group.
Adolescents with endemic goitre given iodine alone or iodine+levothyroxine both corrected deficiency and reduced thyroid volume and lipids, with greater volume reduction in the combination group.
Adolescents with endemic goitre given iodine alone or iodine+levothyroxine both corrected deficiency and reduced thyroid volume and lipids, with greater volume reduction in the combination group.
A single oral iodised-oil dose increased urinary iodine and markedly reduced goitre prevalence at 40 weeks; efficacy was lower in children with poorer weight-for-height.
In euthyroid goitre patients, mono-iodine, combination iodine+levothyroxine, and levothyroxine alone produced similar ~34–39% thyroid volume reductions over 6 months.
In euthyroid goitre patients, mono-iodine, combination iodine+levothyroxine, and levothyroxine alone produced similar ~34–39% thyroid volume reductions over 6 months.
In euthyroid goitre patients, mono-iodine, combination iodine+levothyroxine, and levothyroxine alone produced similar ~34–39% thyroid volume reductions over 6 months.
A reduced-voltage CT protocol with lower-iodine concentration cut iodine dose and radiation while preserving image quality in patients with BMI 18.5–27.9.
A reduced-voltage CT protocol with lower-iodine concentration cut iodine dose and radiation while preserving image quality in patients with BMI 18.5–27.9.
Randomized trial comparing 18 vs 42 months carbimazole found no significant difference in 2-year relapse rates after stopping treatment.
Randomized trial comparing 18 vs 42 months carbimazole found no significant difference in 2-year relapse rates after stopping treatment.
Randomized trial comparing 18 vs 42 months carbimazole found no significant difference in 2-year relapse rates after stopping treatment.
Wet silver dressings healed skin wounds faster, reduced dressing changes and pain compared with povidone-iodine dressings.
Amifostine given before high-dose 131I did not prevent decline in salivary gland function measured by quantitative scans.
Amifostine given before high-dose 131I did not prevent decline in salivary gland function measured by quantitative scans.
Randomized trial in 109 patients found more phlebitis with alcoholic iodine than alcohol alone, but the difference was not statistically significant and the study was underpowered.
Randomized trial in 109 patients found more phlebitis with alcoholic iodine than alcohol alone, but the difference was not statistically significant and the study was underpowered.
Randomized trial comparing low (1.1 GBq) vs high (3.7 GBq) 131I doses in low/intermediate-risk thyroid cancer: ablation and therapeutic responses similar, but fewer adverse reactions with low dose.
Randomized trial comparing low (1.1 GBq) vs high (3.7 GBq) 131I doses in low/intermediate-risk thyroid cancer: ablation and therapeutic responses similar, but fewer adverse reactions with low dose.
6-month randomized, double-blind 2x2 trial in children: vitamin A supplementation decreased TSH stimulation, thyroglobulin, and thyroid volume and thus reduced goiter risk in the context of mild-to-moderate iodine deficiency.
Randomized study comparing TBW, LBW, and BSA-based iodine dosing for abdominal CT: LBW and BSA provided more consistent contrast enhancement than TBW.
Randomized study comparing TBW, LBW, and BSA-based iodine dosing for abdominal CT: LBW and BSA provided more consistent contrast enhancement than TBW.
In an iodine-deficient schoolchildren population, those whose urinary iodine increased over one year showed greater gains in combined mental and psychomotor test performance compared with those whose iodine status did not change.
Randomized trial of reduced iodine dose with 80 kVp CT for pancreas: 400 mg/kg iodine at 80 kVp maintained image quality and tumor detectability while reducing iodine load.
Randomized trial of reduced iodine dose with 80 kVp CT for pancreas: 400 mg/kg iodine at 80 kVp maintained image quality and tumor detectability while reducing iodine load.
In newborns with congenital hypothyroidism due to iodine deficiency, adding 100 µg/day oral iodine to L-T4 provided no additional benefit over L-T4 alone during the first three months.
One-year multicenter community trial: double-fortified salt (iron + iodine) was stable in storage and improved hemoglobin and corrected iodine deficiency similarly to iodized salt; DFS increased hemoglobin more than iodized salt.
In patients with Hashimoto's hypothyroidism, restricting iodine intake for 3 months led many to recover normal thyroid function.
In patients with Hashimoto's hypothyroidism, restricting iodine intake for 3 months led many to recover normal thyroid function.
A randomized trial showing that an individualized 131I dosing method achieved high cure rates while using lower radioactivity than a fixed high-dose approach.
A randomized trial showing that an individualized 131I dosing method achieved high cure rates while using lower radioactivity than a fixed high-dose approach.
Pre-treatment with low-dose rhTSH allowed similar goiter volume reduction with ~70% lower administered 131I activity and far fewer hospitalizations.
A large community trial testing different salt iodine levels showed that 15–24 mg/kg iodization produced adequate urinary iodine levels.
A large community trial testing different salt iodine levels showed that 15–24 mg/kg iodization produced adequate urinary iodine levels.
In patients with thyroid autonomy undergoing iodine exposure, short-term prophylactic antithyroid treatment blunted hormone changes compared with controls.
In patients with thyroid autonomy undergoing iodine exposure, short-term prophylactic antithyroid treatment blunted hormone changes compared with controls.
Compared three iodine doses for CT detection of hypervascular liver cancer and identified a minimal effective dose.
Compared three iodine doses for CT detection of hypervascular liver cancer and identified a minimal effective dose.
Compared three iodine doses for CT detection of hypervascular liver cancer and identified a minimal effective dose.
Compared intrapleural aqueous iodine, doxycycline, and drainage for prolonged air leak after lung surgery; iodine shortened drainage and hospital stay but caused more pleural pain.
Compared intrapleural aqueous iodine, doxycycline, and drainage for prolonged air leak after lung surgery; iodine shortened drainage and hospital stay but caused more pleural pain.
Compared intrapleural aqueous iodine, doxycycline, and drainage for prolonged air leak after lung surgery; iodine shortened drainage and hospital stay but caused more pleural pain.
Households randomized to different salt iodine levels; urinary iodine fell after intervention and current standard may produce slight excess intake.
Households randomized to different salt iodine levels; urinary iodine fell after intervention and current standard may produce slight excess intake.
Households randomized to different salt iodine levels; urinary iodine fell after intervention and current standard may produce slight excess intake.
Compared three radioiodine dosing strategies in Graves' disease and found a thyroid-mass–based method cured as many patients with lower administered activity.
Compared three radioiodine dosing strategies in Graves' disease and found a thyroid-mass–based method cured as many patients with lower administered activity.
Compared three radioiodine dosing strategies in Graves' disease and found a thyroid-mass–based method cured as many patients with lower administered activity.
Long-term follow-up of fellow (untreated) eyes in ocular melanoma trials found minimal visual change and no increased risk from radiotherapy to the treated eye.
Long-term follow-up of fellow (untreated) eyes in ocular melanoma trials found minimal visual change and no increased risk from radiotherapy to the treated eye.
Long-term follow-up of fellow (untreated) eyes in ocular melanoma trials found minimal visual change and no increased risk from radiotherapy to the treated eye.
Randomized trial comparing low-dose-rate (I-125 seed) versus high-dose-rate prostate brachytherapy planning and dose distributions.
Randomized trial comparing low-dose-rate (I-125 seed) versus high-dose-rate prostate brachytherapy planning and dose distributions.
Randomized trial comparing low-dose-rate (I-125 seed) versus high-dose-rate prostate brachytherapy planning and dose distributions.
Within-patient comparison of moderate- vs high-iodine-concentration CT contrast agents and injection methods to assess HCC conspicuity.
Within-patient comparison of moderate- vs high-iodine-concentration CT contrast agents and injection methods to assess HCC conspicuity.
In 30 maintenance hemodialysis patients, HFR caused greater acute reductions in several micronutrients compared with HDF, including serum calcium.
Randomized comparison of integrated I-125 seed stents versus conventional metal stents for malignant lower biliary obstruction.
Randomized comparison of integrated I-125 seed stents versus conventional metal stents for malignant lower biliary obstruction.
Randomized comparison of integrated I-125 seed stents versus conventional metal stents for malignant lower biliary obstruction.
Cross-sectional sampling shows Belgian neonates improved iodine status versus past but still below recommended levels; formula corrected preterm deficiency.
Cross-sectional sampling shows Belgian neonates improved iodine status versus past but still below recommended levels; formula corrected preterm deficiency.
Cross-sectional sampling shows Belgian neonates improved iodine status versus past but still below recommended levels; formula corrected preterm deficiency.
Thyroxine plus iodide reduced goitre volume (~24%); weight‑adjusted thyroxine produced more complete TSH suppression than fixed dosing.
rhTSH preserves quality of life compared with thyroid-hormone withdrawal while achieving comparable low-dose radioiodine remnant ablation success rates.
Two randomized trials showed rTSH-stimulated radioiodine scanning plus thyroglobulin testing is at least as sensitive as thyroid-hormone withdrawal (in improved-tech trial) and causes less hypothyroid morbidity.
Combining I-125 seed implantation with chemotherapy and Chinese medicine increased response rates, reduced tumor markers, and improved quality of life versus chemotherapy alone.
In patients with differentiated thyroid cancer and low preablative thyroglobulin, low-dose radioiodine produced similar ablation rates to high-dose with no recurrences during short follow-up.
Adding 150 µg iodine to individualized L-thyroxine increased urinary iodine and produced greater (though modest) reductions in thyroid volume and stronger TSH suppression versus L-thyroxine alone.
A single postoperative intra-arterial 131I‑lipiodol dose after liver cancer resection reduced local recurrence and improved disease-free and overall survival versus no adjuvant treatment.
A single postoperative intra-arterial 131I‑lipiodol dose after liver cancer resection reduced local recurrence and improved disease-free and overall survival versus no adjuvant treatment.
In this randomized trial there was no conclusive superiority of high vs low radioiodine activity for ablating thyroid remnant; lower activity caused fewer side effects and shorter isolation.
In this randomized trial there was no conclusive superiority of high vs low radioiodine activity for ablating thyroid remnant; lower activity caused fewer side effects and shorter isolation.
In this randomized trial there was no conclusive superiority of high vs low radioiodine activity for ablating thyroid remnant; lower activity caused fewer side effects and shorter isolation.
A fortified biscuit increased urinary iodine and improved vitamin A and iron markers during school terms, but many gains (except urinary iodine) fell back after long school holidays.
Thyroxine plus iodide reduced goitre volume (~24%); weight‑adjusted thyroxine produced more complete TSH suppression than fixed dosing.
Small periodic iodine supplements reduced the occurrence of markedly enlarged thyroids in a subgroup of adolescents, though most children showed similar moderate growth.
Iodine deficiency was present in the population; goiter prevalence rose with age and urinary iodine fell, with higher neonatal TSH observed.
Iodine deficiency was present in the population; goiter prevalence rose with age and urinary iodine fell, with higher neonatal TSH observed.
I-125 seed brachytherapy in 36 prostate cancer patients produced large PSA reductions and was reported safe at 6 months.
Large randomized trial comparing Jiakangling plus reduced 131I versus routine 131I in Graves disease showed mixed effects on recurrence/incidence and reduced permanent hypothyroidism.
Large randomized trial comparing Jiakangling plus reduced 131I versus routine 131I in Graves disease showed mixed effects on recurrence/incidence and reduced permanent hypothyroidism.
Large randomized trial comparing Jiakangling plus reduced 131I versus routine 131I in Graves disease showed mixed effects on recurrence/incidence and reduced permanent hypothyroidism.
In randomized CT protocols, a high-concentration contrast at a fast injection rate produced greater pancreatic enhancement than routine protocols.
In 46 Graves patients with mild/no eye disease, RAI did not increase the risk of developing or worsening ophthalmopathy over 12 months.
In 46 Graves patients with mild/no eye disease, RAI did not increase the risk of developing or worsening ophthalmopathy over 12 months.
Using an adjustable-angle template for 125I seed implantation shortened procedures, reduced CT scans and supplementary seeds, and lowered complication rates versus free‑hand implantation in 45 NSCLC patients.
Using an adjustable-angle template for 125I seed implantation shortened procedures, reduced CT scans and supplementary seeds, and lowered complication rates versus free‑hand implantation in 45 NSCLC patients.
Using an adjustable-angle template for 125I seed implantation shortened procedures, reduced CT scans and supplementary seeds, and lowered complication rates versus free‑hand implantation in 45 NSCLC patients.
I-131 metuximab (Licartin) in Phase I/II HCC trials was well tolerated and showed modest antitumor activity and a 21-month survival ~44.5%.
I-131 metuximab (Licartin) in Phase I/II HCC trials was well tolerated and showed modest antitumor activity and a 21-month survival ~44.5%.
I-131 metuximab (Licartin) in Phase I/II HCC trials was well tolerated and showed modest antitumor activity and a 21-month survival ~44.5%.
I-131 metuximab (Licartin) in Phase I/II HCC trials was well tolerated and showed modest antitumor activity and a 21-month survival ~44.5%.
In a double-blind RCT of DTC patients undergoing thyroid hormone withdrawal, probiotics reduced several withdrawal-related symptoms, improved lipid indices and restored gut/oral microbiota diversity.
In a double-blind RCT of DTC patients undergoing thyroid hormone withdrawal, probiotics reduced several withdrawal-related symptoms, improved lipid indices and restored gut/oral microbiota diversity.
In a double-blind RCT of DTC patients undergoing thyroid hormone withdrawal, probiotics reduced several withdrawal-related symptoms, improved lipid indices and restored gut/oral microbiota diversity.
In a double-blind RCT of DTC patients undergoing thyroid hormone withdrawal, probiotics reduced several withdrawal-related symptoms, improved lipid indices and restored gut/oral microbiota diversity.
In a double-blind RCT of DTC patients undergoing thyroid hormone withdrawal, probiotics reduced several withdrawal-related symptoms, improved lipid indices and restored gut/oral microbiota diversity.
Randomized trial comparing I-125 and Pd-103 seeds for prostate brachytherapy found differences in early and mid-term urinary and rectal side effects: Pd-103 produced worse urinary symptoms early but recovered sooner; I-125 showed a trend toward more rectal bleeding.
Randomized trial comparing I-125 and Pd-103 seeds for prostate brachytherapy found differences in early and mid-term urinary and rectal side effects: Pd-103 produced worse urinary symptoms early but recovered sooner; I-125 showed a trend toward more rectal bleeding.
Randomized single-center study in elderly patients with advanced esophageal cancer found 125I-coated stents relieved dysphagia acutely and were associated with longer mean survival than ordinary stents.
Randomized single-center study in elderly patients with advanced esophageal cancer found 125I-coated stents relieved dysphagia acutely and were associated with longer mean survival than ordinary stents.
Randomized single-center study in elderly patients with advanced esophageal cancer found 125I-coated stents relieved dysphagia acutely and were associated with longer mean survival than ordinary stents.
Multicenter randomized noninferiority trial showed low-dose radioiodine (30 mCi) plus thyrotropin alfa is as effective as high-dose (100 mCi) for thyroid remnant ablation, with fewer adverse events and shorter hospital stays.
Multicenter randomized noninferiority trial showed low-dose radioiodine (30 mCi) plus thyrotropin alfa is as effective as high-dose (100 mCi) for thyroid remnant ablation, with fewer adverse events and shorter hospital stays.
Multicenter randomized noninferiority trial showed low-dose radioiodine (30 mCi) plus thyrotropin alfa is as effective as high-dose (100 mCi) for thyroid remnant ablation, with fewer adverse events and shorter hospital stays.
Randomized study in Graves' disease patients found adding propylthiouracil three days after 131I did not significantly change cure rates at six months.
RhTSH prestimulation before 131I therapy produced greater long-term goiter shrinkage and symptom improvement but caused higher rates of permanent hypothyroidism.
RhTSH prestimulation before 131I therapy produced greater long-term goiter shrinkage and symptom improvement but caused higher rates of permanent hypothyroidism.
RhTSH prestimulation before 131I therapy produced greater long-term goiter shrinkage and symptom improvement but caused higher rates of permanent hypothyroidism.
Large pragmatic cohort study with 6–10 year follow-up found that many patients ultimately undergo ablative treatment and that long-term euthyroidism without levothyroxine is achieved in only a minority.
Large pragmatic cohort study with 6–10 year follow-up found that many patients ultimately undergo ablative treatment and that long-term euthyroidism without levothyroxine is achieved in only a minority.
Large pragmatic cohort study with 6–10 year follow-up found that many patients ultimately undergo ablative treatment and that long-term euthyroidism without levothyroxine is achieved in only a minority.
RCT comparing fixed 370 vs 555 MBq I-131 for Graves disease: similar remission at 12 months; higher (nonsignificant) hypothyroidism with the larger dose; no new/worsened eye disease.
Prospective randomized comparison of four I-131 dosing protocols for single toxic thyroid nodule: high calculated dose (CHD) gave higher cure rates but also higher hypothyroidism; calculated low dose (CLD) had similar cure to fixed low dose with less hypothyroidism.
RCT comparing fixed 370 vs 555 MBq I-131 for Graves disease: similar remission at 12 months; higher (nonsignificant) hypothyroidism with the larger dose; no new/worsened eye disease.
RCT comparing fixed 370 vs 555 MBq I-131 for Graves disease: similar remission at 12 months; higher (nonsignificant) hypothyroidism with the larger dose; no new/worsened eye disease.
Randomized study of biliary stent ± I-125 seeds in malignant biliary obstruction: I-125 seeds increased stent patency and overall survival without added procedure complications.
Randomized study of biliary stent ± I-125 seeds in malignant biliary obstruction: I-125 seeds increased stent patency and overall survival without added procedure complications.
Prospective randomized comparison of four I-131 dosing protocols for single toxic thyroid nodule: high calculated dose (CHD) gave higher cure rates but also higher hypothyroidism; calculated low dose (CLD) had similar cure to fixed low dose with less hypothyroidism.
Prospective randomized comparison of four I-131 dosing protocols for single toxic thyroid nodule: high calculated dose (CHD) gave higher cure rates but also higher hypothyroidism; calculated low dose (CLD) had similar cure to fixed low dose with less hypothyroidism.
Randomized study comparing calculated vs fixed I-131 doses for hyperthyroidism; no difference in 12-month thyroid outcomes; both reduced gland volume.
Randomized trial comparing estimated (palpation) versus calculated I-131 dosing in hyperthyroid patients; outcomes at 12 months did not differ by dosing method.
Randomized trial comparing estimated (palpation) versus calculated I-131 dosing in hyperthyroid patients; outcomes at 12 months did not differ by dosing method.
Randomized study comparing calculated vs fixed I-131 doses for hyperthyroidism; no difference in 12-month thyroid outcomes; both reduced gland volume.
Randomized study comparing calculated vs fixed I-131 doses for hyperthyroidism; no difference in 12-month thyroid outcomes; both reduced gland volume.
Randomized trial comparing estimated (palpation) versus calculated I-131 dosing in hyperthyroid patients; outcomes at 12 months did not differ by dosing method.
Randomized trial in patients with hyperthyroidism relapse after prior RAI: long-term methimazole led to faster and more sustained euthyroidism than repeat RAI.
Randomized trial in patients with hyperthyroidism relapse after prior RAI: long-term methimazole led to faster and more sustained euthyroidism than repeat RAI.
Randomized trial in patients with hyperthyroidism relapse after prior RAI: long-term methimazole led to faster and more sustained euthyroidism than repeat RAI.
Randomized trial in HCC patients: intraoperative implantation of I-125 seeds into remnant liver after resection reduced recurrence and improved overall survival versus control.
Randomized trial in HCC patients: intraoperative implantation of I-125 seeds into remnant liver after resection reduced recurrence and improved overall survival versus control.
Randomized trial in HCC patients: intraoperative implantation of I-125 seeds into remnant liver after resection reduced recurrence and improved overall survival versus control.
Randomized trial comparing antithyroid‑drug pretreatment vs no pretreatment before I-131 ablation; pretreatment led to transient rises in T4/T3 after stopping drugs, whereas nonpretreated patients had rapid hormone declines after RAI.
Randomized trial comparing antithyroid‑drug pretreatment vs no pretreatment before I-131 ablation; pretreatment led to transient rises in T4/T3 after stopping drugs, whereas nonpretreated patients had rapid hormone declines after RAI.
Randomized trial comparing antithyroid‑drug pretreatment vs no pretreatment before I-131 ablation; pretreatment led to transient rises in T4/T3 after stopping drugs, whereas nonpretreated patients had rapid hormone declines after RAI.
In prostate brachytherapy patients, higher rectal wall doses and more seeds very close to the rectal wall were associated with persistent rectal bleeding; overall persistent bleeding occurred in ~5%.
Higher rectal radiation dose during prostate brachytherapy was linked to more persistent rectal bleeding; two patients developed rectal‑prostatic fistulas.
Higher rectal radiation dose during prostate brachytherapy was linked to more persistent rectal bleeding; two patients developed rectal‑prostatic fistulas.
Higher rectal radiation dose during prostate brachytherapy was linked to more persistent rectal bleeding; two patients developed rectal‑prostatic fistulas.
Adding selumetinib to adjuvant radioactive iodine did not increase complete remission rates at 18 months versus placebo, and selumetinib had more grade ≥3 adverse events.
Adding selumetinib to adjuvant radioactive iodine did not increase complete remission rates at 18 months versus placebo, and selumetinib had more grade ≥3 adverse events.
Pre-treatment with low-dose rhTSH allowed similar goiter volume reduction with ~70% lower administered 131I activity and far fewer hospitalizations.
Pre-treatment with low-dose rhTSH allowed similar goiter volume reduction with ~70% lower administered 131I activity and far fewer hospitalizations.
Adding 131I-labeled metuximab to TACE improved time to progression and average survival versus TACE alone in relapsed mid/advanced hepatocellular carcinoma.
Adding 131I-labeled metuximab to TACE improved time to progression and average survival versus TACE alone in relapsed mid/advanced hepatocellular carcinoma.
Adding 131I-labeled metuximab to TACE improved time to progression and average survival versus TACE alone in relapsed mid/advanced hepatocellular carcinoma.
In patients treated with radioiodine (and other therapies), smokers had worse eye disease outcomes and responded less well to treatments than nonsmokers.
In patients treated with radioiodine (and other therapies), smokers had worse eye disease outcomes and responded less well to treatments than nonsmokers.
In patients treated with radioiodine (and other therapies), smokers had worse eye disease outcomes and responded less well to treatments than nonsmokers.
Adding I-125 seed brachytherapy to sphincter-preserving surgery reduced local recurrences and improved 3-year survival and some functional outcomes.
Adding I-125 seed brachytherapy to sphincter-preserving surgery reduced local recurrences and improved 3-year survival and some functional outcomes.
Radioiodine therapy produced large, dose-dependent reductions in thyroid volume, most of which occurred within six months and progressed by one year.
At 5 years, omitting postoperative radioactive iodine in low‑risk thyroid cancer was non-inferior to giving RAI, with similar proportions of patients free of events.
Tailored radioiodine dosing plus optional low-dose antithyroid drug was assessed for treating Graves' disease versus a fixed-dose control.
Tailored radioiodine dosing plus optional low-dose antithyroid drug was assessed for treating Graves' disease versus a fixed-dose control.
Tailored radioiodine dosing plus optional low-dose antithyroid drug was assessed for treating Graves' disease versus a fixed-dose control.
Compared Lipiodol-targeted epirubicin chemotherapy versus Lipiodol-131I radiotherapy in 95 patients with unresectable liver cancer for tumor response and survival.
Compared Lipiodol-targeted epirubicin chemotherapy versus Lipiodol-131I radiotherapy in 95 patients with unresectable liver cancer for tumor response and survival.
Compared Lipiodol-targeted epirubicin chemotherapy versus Lipiodol-131I radiotherapy in 95 patients with unresectable liver cancer for tumor response and survival.
Randomized study showing short-course lithium prevents rises in serum thyroid hormones after antithyroid drug withdrawal and radioiodine therapy in Graves' disease.
Randomized study showing short-course lithium prevents rises in serum thyroid hormones after antithyroid drug withdrawal and radioiodine therapy in Graves' disease.
Randomized study showing short-course lithium prevents rises in serum thyroid hormones after antithyroid drug withdrawal and radioiodine therapy in Graves' disease.
Randomized trial in 80 patients comparing vertebroplasty alone versus vertebroplasty plus 125I seed implantation for metastatic spinal tumors, focusing on pain and function.
Randomized trial in 80 patients comparing vertebroplasty alone versus vertebroplasty plus 125I seed implantation for metastatic spinal tumors, focusing on pain and function.
Randomized trial in 80 patients comparing vertebroplasty alone versus vertebroplasty plus 125I seed implantation for metastatic spinal tumors, focusing on pain and function.
Phase 3 randomized trial showing omission of postoperative radioiodine in low-risk thyroid cancer was noninferior to radioiodine ablation for a 3-year composite outcome.
Phase 3 randomized trial showing omission of postoperative radioiodine in low-risk thyroid cancer was noninferior to radioiodine ablation for a 3-year composite outcome.
Compared two iodine-containing contrast agents for safety and image quality; similar efficacy and safety, with fewer cases of contrast-related kidney injury after iosimenol.
Phase 3 randomized trial showing omission of postoperative radioiodine in low-risk thyroid cancer was noninferior to radioiodine ablation for a 3-year composite outcome.
Long-term follow-up found Graves' disease patients had reduced vitality and mental quality-of-life compared with population norms; no major QoL differences between antithyroid drugs, radioiodine, or surgery.
Long-term follow-up found Graves' disease patients had reduced vitality and mental quality-of-life compared with population norms; no major QoL differences between antithyroid drugs, radioiodine, or surgery.
Long-term follow-up found Graves' disease patients had reduced vitality and mental quality-of-life compared with population norms; no major QoL differences between antithyroid drugs, radioiodine, or surgery.
In patients with cervical lymph node metastases, adding CT-guided I-125 seed implantation to chemotherapy produced higher tumor response and lower local progression at 6 months than chemotherapy alone.
In patients with cervical lymph node metastases, adding CT-guided I-125 seed implantation to chemotherapy produced higher tumor response and lower local progression at 6 months than chemotherapy alone.
In patients with cervical lymph node metastases, adding CT-guided I-125 seed implantation to chemotherapy produced higher tumor response and lower local progression at 6 months than chemotherapy alone.
Periocular triamcinolone given at radiotherapy and at 4 and 8 months reduced macular edema and lowered rates of moderate and severe vision loss up to 18 months.
Periocular triamcinolone given at radiotherapy and at 4 and 8 months reduced macular edema and lowered rates of moderate and severe vision loss up to 18 months.
Periocular triamcinolone given at radiotherapy and at 4 and 8 months reduced macular edema and lowered rates of moderate and severe vision loss up to 18 months.
In prostate brachytherapy patients, higher rectal wall doses and more seeds very close to the rectal wall were associated with persistent rectal bleeding; overall persistent bleeding occurred in ~5%.
In prostate brachytherapy patients, higher rectal wall doses and more seeds very close to the rectal wall were associated with persistent rectal bleeding; overall persistent bleeding occurred in ~5%.
Pretreatment with propylthiouracil (PTU) before 131I therapy altered early thyroid hormone responses and reduced the radioiodine cure rate (significant in regression analysis).
Pretreatment with propylthiouracil (PTU) before 131I therapy altered early thyroid hormone responses and reduced the radioiodine cure rate (significant in regression analysis).
Compared quintuply-fortified salt (including iodine) versus iodized salt in nonpregnant reproductive-age women; QFS improved several micronutrient deficiencies versus iodized salt.
Compared quintuply-fortified salt (including iodine) versus iodized salt in nonpregnant reproductive-age women; QFS improved several micronutrient deficiencies versus iodized salt.
Compared quintuply-fortified salt (including iodine) versus iodized salt in nonpregnant reproductive-age women; QFS improved several micronutrient deficiencies versus iodized salt.
Phase II randomized comparison of LDR (I-125 seeds) versus HDR prostate brachytherapy measuring dose coverage to MRI-defined dominant intraprostatic lesions.
Phase II randomized comparison of LDR (I-125 seeds) versus HDR prostate brachytherapy measuring dose coverage to MRI-defined dominant intraprostatic lesions.
Randomized trial testing whether restarting methimazole 7 days after 131I alters outcomes; no difference in final thyroid function but less early thyrotoxicosis and smaller goitre shrinkage with resumed methimazole.
Randomized trial testing whether restarting methimazole 7 days after 131I alters outcomes; no difference in final thyroid function but less early thyrotoxicosis and smaller goitre shrinkage with resumed methimazole.
Randomized trial testing whether restarting methimazole 7 days after 131I alters outcomes; no difference in final thyroid function but less early thyrotoxicosis and smaller goitre shrinkage with resumed methimazole.
Phase 3 randomized trial showed low-dose postoperative 131I (1.1 GBq) with recombinant TSH is as effective as higher dose (3.7 GBq) for thyroid ablation in low-risk patients.
Randomized study of neoadjuvant hormonal therapy before I-125 seed implantation showed rapid PSA and prostate-volume reductions pre-implant and lower subsequent PSA compared with implantation alone.
Randomized study of neoadjuvant hormonal therapy before I-125 seed implantation showed rapid PSA and prostate-volume reductions pre-implant and lower subsequent PSA compared with implantation alone.
Randomized study of neoadjuvant hormonal therapy before I-125 seed implantation showed rapid PSA and prostate-volume reductions pre-implant and lower subsequent PSA compared with implantation alone.
Randomized comparison in relapsed/refractory NHL showed that conjugating 131I to tositumomab substantially increased response rates and durability but increased hematologic toxicity.
Randomized comparison in inoperable advanced NSCLC found I-125 seed implantation yielded higher response rates, better survival and improved symptoms/quality of life versus conventional radiotherapy.
Randomized comparison in inoperable advanced NSCLC found I-125 seed implantation yielded higher response rates, better survival and improved symptoms/quality of life versus conventional radiotherapy.
A decision aid increased patients' knowledge and reduced decisional conflict about adjuvant radioactive iodine without significantly changing treatment uptake.
A decision aid increased patients' knowledge and reduced decisional conflict about adjuvant radioactive iodine without significantly changing treatment uptake.
A decision aid increased patients' knowledge and reduced decisional conflict about adjuvant radioactive iodine without significantly changing treatment uptake.
123I-MIBG heart/mediastinum uptake ratios were lower in Parkinson's patients and correlated with some measures of cardiac autonomic dysfunction.
123I-MIBG heart/mediastinum uptake ratios were lower in Parkinson's patients and correlated with some measures of cardiac autonomic dysfunction.
123I-MIBG heart/mediastinum uptake ratios were lower in Parkinson's patients and correlated with some measures of cardiac autonomic dysfunction.
Combining percutaneous vertebroplasty with 125I seed implantation provided high rates of pain relief and improved function compared with regular radiotherapy.
Combining percutaneous vertebroplasty with 125I seed implantation provided high rates of pain relief and improved function compared with regular radiotherapy.
Combining percutaneous vertebroplasty with 125I seed implantation provided high rates of pain relief and improved function compared with regular radiotherapy.
Peri-procedural intravenous saline hydration markedly reduced the incidence and early severity of contrast-induced acute renal insufficiency.
Peri-procedural intravenous saline hydration markedly reduced the incidence and early severity of contrast-induced acute renal insufficiency.
Amifostine given before high-dose radioiodine prevented salivary gland functional decline and xerostomia compared with placebo.
Amifostine given before high-dose radioiodine prevented salivary gland functional decline and xerostomia compared with placebo.
Amifostine given before high-dose radioiodine prevented salivary gland functional decline and xerostomia compared with placebo.
After I-125 brachytherapy for medium-sized choroidal melanoma, posterior pole abnormalities and retinopathy/optic neuropathy increased over 8 years.
After I-125 brachytherapy for medium-sized choroidal melanoma, posterior pole abnormalities and retinopathy/optic neuropathy increased over 8 years.
After I-125 brachytherapy for medium-sized choroidal melanoma, posterior pole abnormalities and retinopathy/optic neuropathy increased over 8 years.
Randomized trial testing intrahepatic 131I-lipiodol after liver cancer surgery found no clear survival benefit and a few radiation-related adverse events.
Randomized trial testing intrahepatic 131I-lipiodol after liver cancer surgery found no clear survival benefit and a few radiation-related adverse events.
Study of thyroid tumor and matched normal tissue from individuals exposed to I-131 after Chernobyl found 11 genes with dose-dependent differential expression.
Study of thyroid tumor and matched normal tissue from individuals exposed to I-131 after Chernobyl found 11 genes with dose-dependent differential expression.
Study of thyroid tumor and matched normal tissue from individuals exposed to I-131 after Chernobyl found 11 genes with dose-dependent differential expression.
Study of thyroid tumor and matched normal tissue from individuals exposed to I-131 after Chernobyl found 11 genes with dose-dependent differential expression.
Study of thyroid tumor and matched normal tissue from individuals exposed to I-131 after Chernobyl found 11 genes with dose-dependent differential expression.
Randomized comparison of 125I brachytherapy vs transpupillary thermotherapy for small choroidal melanoma showed distinct long-term choroidal vascular changes, with brachytherapy causing more vessel closure and vascular wall staining.
Randomized comparison of 125I brachytherapy vs transpupillary thermotherapy for small choroidal melanoma showed distinct long-term choroidal vascular changes, with brachytherapy causing more vessel closure and vascular wall staining.
Randomized comparison of 125I brachytherapy vs transpupillary thermotherapy for small choroidal melanoma showed distinct long-term choroidal vascular changes, with brachytherapy causing more vessel closure and vascular wall staining.
Higher therapeutic I-131 dose (3700 MBq) produced more successful removal of residual thyroid tissue than a lower dose (1110 MBq).
Higher therapeutic I-131 dose (3700 MBq) produced more successful removal of residual thyroid tissue than a lower dose (1110 MBq).
Using radioiodine uptake and thyroglobulin to guide 131I dose reduced administered activity and increased ablation success versus fixed dosing.
Using radioiodine uptake and thyroglobulin to guide 131I dose reduced administered activity and increased ablation success versus fixed dosing.
Using radioiodine uptake and thyroglobulin to guide 131I dose reduced administered activity and increased ablation success versus fixed dosing.
A higher I-131 dose (100 mCi) achieved higher ablation success than 50 mCi in this small randomized trial.
Using a radioactive I-125 seed to localize nonpalpable breast lesions reduced the need for additional margin resection compared with wire localization.
Using a radioactive I-125 seed to localize nonpalpable breast lesions reduced the need for additional margin resection compared with wire localization.
A diagnostic 185 MBq dose of I-131 reduced subsequent thyroid uptake and impaired immediate therapeutic imaging/therapy in some patients (thyroid stunning).
A diagnostic 185 MBq dose of I-131 reduced subsequent thyroid uptake and impaired immediate therapeutic imaging/therapy in some patients (thyroid stunning).
I-123 MIBG cardiac imaging before carvedilol treatment predicted which heart failure patients showed LVEF and functional improvement.
I-123 MIBG cardiac imaging before carvedilol treatment predicted which heart failure patients showed LVEF and functional improvement.
I-123 MIBG cardiac imaging before carvedilol treatment predicted which heart failure patients showed LVEF and functional improvement.
Large randomized noninferiority trial showing lower I-131 activities (0.93 and 1.85 GBq) are equivalent to 3.7 GBq for remnant ablation at 6 months.
Adding short-course oral lithium to 30 mCi 131I improved remnant ablation success at one year in low-risk thyroid cancer patients.
Adding short-course oral lithium to 30 mCi 131I improved remnant ablation success at one year in low-risk thyroid cancer patients.
Large phase III trial found no significant improvement in 2-year progression-free or overall survival from adding I-131 tositumomab consolidation to CHOP+rituximab.
125I radioactive seed implantation combined with EGFR-TKIs improved tumor response, disease control, PFS and 2-year survival versus EGFR-TKIs alone in advanced EGFR-mutant NSCLC.
125I radioactive seed implantation combined with EGFR-TKIs improved tumor response, disease control, PFS and 2-year survival versus EGFR-TKIs alone in advanced EGFR-mutant NSCLC.
125I radioactive seed implantation combined with EGFR-TKIs improved tumor response, disease control, PFS and 2-year survival versus EGFR-TKIs alone in advanced EGFR-mutant NSCLC.
Randomized prospective study found adding I-125 brachytherapy to chemotherapy improved local control, response rate, and progression-free survival vs chemotherapy alone in locally recurrent stage III NSCLC.
Large randomized trial found no significant difference in overall mortality or melanoma-specific mortality between I-125 brachytherapy and enucleation for choroidal melanoma.
Adding intrahepatic arterial 131I-labelled anti-HCC antibody to hepatic artery ligation increased long-term survival and made more tumors resectable.
Adding intrahepatic arterial 131I-labelled anti-HCC antibody to hepatic artery ligation increased long-term survival and made more tumors resectable.
Adding intrahepatic arterial 131I-labelled anti-HCC antibody to hepatic artery ligation increased long-term survival and made more tumors resectable.
Using rhTSH before radioiodine ablation avoids hypothyroidism and greatly reduces sick-leave without reducing ablation efficacy.
Using rhTSH before radioiodine ablation avoids hypothyroidism and greatly reduces sick-leave without reducing ablation efficacy.
Using rhTSH before radioiodine ablation avoids hypothyroidism and greatly reduces sick-leave without reducing ablation efficacy.
CT-guided permanent 125I seed implantation improved local tumor control and resulted in longer survival compared with radiochemotherapy for pelvic recurrence after cervical cancer surgery.
CT-guided permanent 125I seed implantation improved local tumor control and resulted in longer survival compared with radiochemotherapy for pelvic recurrence after cervical cancer surgery.
In thyroid cancer patients, rhTSH stimulation before 131I ablation resulted in lower red-marrow absorbed dose and lower remnant uptake compared with L-T4 withdrawal (hypothyroidism).
In thyroid cancer patients, rhTSH stimulation before 131I ablation resulted in lower red-marrow absorbed dose and lower remnant uptake compared with L-T4 withdrawal (hypothyroidism).
In thyroid cancer patients, rhTSH stimulation before 131I ablation resulted in lower red-marrow absorbed dose and lower remnant uptake compared with L-T4 withdrawal (hypothyroidism).
Adding interstitial I-125 seed implantation to chemotherapy improved tumor response and local control with acceptable toxicity.
Prospective study of CT‑guided iodine‑125 brachytherapy for bilateral lung metastases from colorectal cancer showed high procedural success, acceptable safety, improved local control and significantly longer overall survival versus symptomatic care.
Adding interstitial I-125 seed implantation to chemotherapy improved tumor response and local control with acceptable toxicity.
PEI before radioiodine reduced nodule volume, allowed a lower radioiodine dose, and improved symptoms versus radioiodine alone.
PEI before radioiodine reduced nodule volume, allowed a lower radioiodine dose, and improved symptoms versus radioiodine alone.
PEI before radioiodine reduced nodule volume, allowed a lower radioiodine dose, and improved symptoms versus radioiodine alone.
Combining I-125 seed implantation with chemotherapy and Chinese medicine increased response rates, reduced tumor markers, and improved quality of life versus chemotherapy alone.
Combining I-125 seed implantation with chemotherapy and Chinese medicine increased response rates, reduced tumor markers, and improved quality of life versus chemotherapy alone.
Stereotactically implanted I-125 seed catheters achieved high conformity, though spatial deviations (mean 2.0 mm) sometimes reduced delivered dose.
Stereotactically implanted I-125 seed catheters achieved high conformity, though spatial deviations (mean 2.0 mm) sometimes reduced delivered dose.
Stereotactically implanted I-125 seed catheters achieved high conformity, though spatial deviations (mean 2.0 mm) sometimes reduced delivered dose.
Stopping methimazole 7 days before I-131 or giving no pretreatment resulted in high I-131 treatment success (~96%), whereas continuing methimazole until I-131 markedly reduced success to 63.8%.
Stopping methimazole 7 days before I-131 or giving no pretreatment resulted in high I-131 treatment success (~96%), whereas continuing methimazole until I-131 markedly reduced success to 63.8%.
In 60 thyroid cancer patients researchers defined a quantitative detection limit for iodine-131 uptake on neck scans; this LoD matched specialists' ratings and was lower after rhTSH than after thyroid hormone withdrawal.
In 60 thyroid cancer patients researchers defined a quantitative detection limit for iodine-131 uptake on neck scans; this LoD matched specialists' ratings and was lower after rhTSH than after thyroid hormone withdrawal.
In 60 thyroid cancer patients researchers defined a quantitative detection limit for iodine-131 uptake on neck scans; this LoD matched specialists' ratings and was lower after rhTSH than after thyroid hormone withdrawal.
In 60 thyroid cancer patients researchers defined a quantitative detection limit for iodine-131 uptake on neck scans; this LoD matched specialists' ratings and was lower after rhTSH than after thyroid hormone withdrawal.
Randomized trial of 313 Graves' patients found radioiodine treatment increased the risk of developing or worsening eye disease (TAO) compared with antithyroid drugs, with smokers at highest risk.
Randomized trial of 313 Graves' patients found radioiodine treatment increased the risk of developing or worsening eye disease (TAO) compared with antithyroid drugs, with smokers at highest risk.
Randomized trial of 313 Graves' patients found radioiodine treatment increased the risk of developing or worsening eye disease (TAO) compared with antithyroid drugs, with smokers at highest risk.
In 308 Graves' patients randomized to radioiodine or medical therapy, those who developed or worsened thyroid-associated ophthalmopathy had lower quality of life; TAO occurred more often in patients exposed to radioiodine.
In 308 Graves' patients randomized to radioiodine or medical therapy, those who developed or worsened thyroid-associated ophthalmopathy had lower quality of life; TAO occurred more often in patients exposed to radioiodine.
Among patients treated with radioiodide for Graves' disease or autonomous nodules, oral and intravenous administration produced similar achieved therapeutic doses and similar clinical outcomes at 6 months.
Among patients treated with radioiodide for Graves' disease or autonomous nodules, oral and intravenous administration produced similar achieved therapeutic doses and similar clinical outcomes at 6 months.
Among patients treated with radioiodide for Graves' disease or autonomous nodules, oral and intravenous administration produced similar achieved therapeutic doses and similar clinical outcomes at 6 months.
In 504 low-risk thyroid cancer patients, omission of postoperative radioiodine ablation was non-inferior to ablation for 5-year recurrence-free survival; adverse events were similar.
A single postoperative intraarterial 131I-lipiodol dose reduced intrahepatic recurrence after curative HCC treatment but did not improve overall survival.
In 72 thyroid cancer patients prepared with rhTSH, 1850 MBq and 3700 MBq of iodine-131 achieved similar successful ablation rates.
In 72 thyroid cancer patients prepared with rhTSH, 1850 MBq and 3700 MBq of iodine-131 achieved similar successful ablation rates.
In patients with very large multinodular goiters, giving 0.3 mg rhTSH before I-131 improved thyroid shrinkage but increased transient adverse effects.
In patients with very large multinodular goiters, giving 0.3 mg rhTSH before I-131 improved thyroid shrinkage but increased transient adverse effects.
Long-term randomized study found no superiority of 3.7 GBq over 1.1 GBq I-131 for thyroid remnant ablation in low-risk differentiated thyroid cancer.
Long-term randomized study found no superiority of 3.7 GBq over 1.1 GBq I-131 for thyroid remnant ablation in low-risk differentiated thyroid cancer.
Patients with Graves' eye disease had either near-total thyroidectomy or thyroidectomy plus radioiodine ablation and were followed for eye improvement.
Patients with Graves' eye disease had either near-total thyroidectomy or thyroidectomy plus radioiodine ablation and were followed for eye improvement.
Patients with Graves' eye disease had either near-total thyroidectomy or thyroidectomy plus radioiodine ablation and were followed for eye improvement.
Large series of eye melanoma patients showed that late tumor recurrences (>5 years) occurred after iodine-125 plaque radiation more often than after charged-particle therapy.
Large series of eye melanoma patients showed that late tumor recurrences (>5 years) occurred after iodine-125 plaque radiation more often than after charged-particle therapy.
Patients with moderate-to-severe Graves' eye disease who had thyroidectomy plus postoperative radioiodine ablation showed greater and earlier eye disease improvement than surgery alone.
Patients with moderate-to-severe Graves' eye disease who had thyroidectomy plus postoperative radioiodine ablation showed greater and earlier eye disease improvement than surgery alone.
Patients with moderate-to-severe Graves' eye disease who had thyroidectomy plus postoperative radioiodine ablation showed greater and earlier eye disease improvement than surgery alone.
Analysis of all patients evaluated for the COMS trial showed who was eligible and who enrolled, supporting that enrolled patients were similar to treated patients meeting trial criteria.
Analysis of all patients evaluated for the COMS trial showed who was eligible and who enrolled, supporting that enrolled patients were similar to treated patients meeting trial criteria.
Analysis of all patients evaluated for the COMS trial showed who was eligible and who enrolled, supporting that enrolled patients were similar to treated patients meeting trial criteria.
Many irradiated eyes retained useful vision for years, but vision loss risk depended on tumor size/location and was highest soon after treatment.
Many irradiated eyes retained useful vision for years, but vision loss risk depended on tumor size/location and was highest soon after treatment.
Many irradiated eyes retained useful vision for years, but vision loss risk depended on tumor size/location and was highest soon after treatment.
Low-dose modified-release rhTSH before I-131 increased short-term goiter shrinkage at one dose but did not show consistent long-term benefit and was associated with higher permanent hypothyroidism at higher dose.
Low-dose modified-release rhTSH before I-131 increased short-term goiter shrinkage at one dose but did not show consistent long-term benefit and was associated with higher permanent hypothyroidism at higher dose.
Low-dose modified-release rhTSH before I-131 increased short-term goiter shrinkage at one dose but did not show consistent long-term benefit and was associated with higher permanent hypothyroidism at higher dose.
Adding lithium to radioiodine treatment did not change cure rates for hyperthyroidism but caused mild-moderate side effects in ~10% of patients.
Adding lithium to radioiodine treatment did not change cure rates for hyperthyroidism but caused mild-moderate side effects in ~10% of patients.
Adding lithium to radioiodine treatment did not change cure rates for hyperthyroidism but caused mild-moderate side effects in ~10% of patients.
Intraoperative I-125 brachytherapy plus chemotherapy increased tumor response, relieved pain, and improved short-term survival versus control in advanced pancreatic cancer.
Intraoperative I-125 brachytherapy plus chemotherapy increased tumor response, relieved pain, and improved short-term survival versus control in advanced pancreatic cancer.
Intraoperative I-125 brachytherapy plus chemotherapy increased tumor response, relieved pain, and improved short-term survival versus control in advanced pancreatic cancer.
Randomized trial in men receiving 125I prostate implantation comparing three α1-blockers; silodosin produced the best short-term improvement in urinary symptoms.
Randomized trial in men receiving 125I prostate implantation comparing three α1-blockers; silodosin produced the best short-term improvement in urinary symptoms.
Randomized trial in men receiving 125I prostate implantation comparing three α1-blockers; silodosin produced the best short-term improvement in urinary symptoms.
Randomised multicentre phase 2 trial showing adjuvant 131I‑metuximab after liver resection for CD147+ HCC improved 5-year recurrence-free survival versus no adjuvant treatment.
Randomised multicentre phase 2 trial showing adjuvant 131I‑metuximab after liver resection for CD147+ HCC improved 5-year recurrence-free survival versus no adjuvant treatment.
Phase II randomized study showing CT-guided 125I-seed implantation plus FOLFIRI markedly improved local tumor response and local control time versus FOLFIRI alone for locally recurrent rectal cancer.
Phase II randomized study showing CT-guided 125I-seed implantation plus FOLFIRI markedly improved local tumor response and local control time versus FOLFIRI alone for locally recurrent rectal cancer.
Phase II randomized study showing CT-guided 125I-seed implantation plus FOLFIRI markedly improved local tumor response and local control time versus FOLFIRI alone for locally recurrent rectal cancer.
Randomized study showing stopping methimazole before 131I causes a transient rise in thyroid hormones pre- and early post‑radioiodine; hormone levels then stabilize or fall over 30 days.
Randomized study showing stopping methimazole before 131I causes a transient rise in thyroid hormones pre- and early post‑radioiodine; hormone levels then stabilize or fall over 30 days.
Randomized study showing stopping methimazole before 131I causes a transient rise in thyroid hormones pre- and early post‑radioiodine; hormone levels then stabilize or fall over 30 days.
Long-term follow-up of the HiLo randomized trial showed low-dose (1.1 GBq) radioactive iodine ablation had similar recurrence rates to high-dose (3.7 GBq); preparation with rhTSH and withdrawal had similar recurrence risks.
Adding rituximab to radioiodine improved thyroid control and several eye measures in patients with Graves' ophthalmopathy.
Adding rituximab to radioiodine improved thyroid control and several eye measures in patients with Graves' ophthalmopathy.
Adding rituximab to radioiodine improved thyroid control and several eye measures in patients with Graves' ophthalmopathy.
Low-dose (800 MBq) I-131 was similarly effective as high-dose (3700 MBq) for remnant ablation in low-risk differentiated thyroid cancer.
Low-dose (800 MBq) I-131 was similarly effective as high-dose (3700 MBq) for remnant ablation in low-risk differentiated thyroid cancer.
Low-dose (800 MBq) I-131 was similarly effective as high-dose (3700 MBq) for remnant ablation in low-risk differentiated thyroid cancer.
Thiamazole pretreatment roughly doubled thyroid radioiodine uptake and lowered the calculated therapeutic radioiodine dose needed for cure.
Thiamazole pretreatment roughly doubled thyroid radioiodine uptake and lowered the calculated therapeutic radioiodine dose needed for cure.
Thiamazole pretreatment roughly doubled thyroid radioiodine uptake and lowered the calculated therapeutic radioiodine dose needed for cure.
A single postoperative intraarterial 131I-lipiodol dose reduced intrahepatic recurrence after curative HCC treatment but did not improve overall survival.
A single postoperative intraarterial 131I-lipiodol dose reduced intrahepatic recurrence after curative HCC treatment but did not improve overall survival.
Stents loaded with 125I seeds prolonged median overall survival compared with conventional stents in unresectable oesophageal cancer.
Stents loaded with 125I seeds prolonged median overall survival compared with conventional stents in unresectable oesophageal cancer.
Iodine-125 brachytherapy showed no difference in long-term survival compared with enucleation for choroidal melanoma.
Iodine-125 brachytherapy showed no difference in long-term survival compared with enucleation for choroidal melanoma.
Iodine-125 brachytherapy showed no difference in long-term survival compared with enucleation for choroidal melanoma.
I-125 brachytherapy for medium choroidal melanoma resulted in substantial visual acuity decline for many treated eyes over 3 years; tumor size and proximity to fovea increased risk of poor vision outcomes.
I-125 brachytherapy for medium choroidal melanoma resulted in substantial visual acuity decline for many treated eyes over 3 years; tumor size and proximity to fovea increased risk of poor vision outcomes.
I-125 brachytherapy for medium choroidal melanoma resulted in substantial visual acuity decline for many treated eyes over 3 years; tumor size and proximity to fovea increased risk of poor vision outcomes.
Randomized comparison in relapsed/refractory NHL showed that conjugating 131I to tositumomab substantially increased response rates and durability but increased hematologic toxicity.
Randomized comparison in relapsed/refractory NHL showed that conjugating 131I to tositumomab substantially increased response rates and durability but increased hematologic toxicity.
Two randomized trials showed rTSH-stimulated radioiodine scanning plus thyroglobulin testing is at least as sensitive as thyroid-hormone withdrawal (in improved-tech trial) and causes less hypothyroid morbidity.
Two randomized trials showed rTSH-stimulated radioiodine scanning plus thyroglobulin testing is at least as sensitive as thyroid-hormone withdrawal (in improved-tech trial) and causes less hypothyroid morbidity.
rhTSH preserves quality of life compared with thyroid-hormone withdrawal while achieving comparable low-dose radioiodine remnant ablation success rates.
PSA spikes after brachytherapy were common and were more frequent with iodine-125 than with palladium-103, especially in patients under 65.
PSA spikes after brachytherapy were common and were more frequent with iodine-125 than with palladium-103, especially in patients under 65.
PSA spikes after brachytherapy were common and were more frequent with iodine-125 than with palladium-103, especially in patients under 65.
Low-dose I-131 (1850 MBq) was as effective as high-dose (3700 MBq) for remnant ablation in Chinese patients with differentiated thyroid cancer.
Adding an iodine-125 seed strand to TACE improved survival compared with TACE alone in patients with hepatocellular carcinoma and portal vein tumor thrombosis.
Adding an iodine-125 seed strand to TACE improved survival compared with TACE alone in patients with hepatocellular carcinoma and portal vein tumor thrombosis.
Three-year biochemical control rates were similar after iodine-125 and palladium-103 brachytherapy for low-risk prostate cancer.
Three-year biochemical control rates were similar after iodine-125 and palladium-103 brachytherapy for low-risk prostate cancer.
Randomized trial in Graves' disease comparing radioiodine alone versus methimazole pretreatment then radioiodine: cure rates and 1-year outcomes were similar between groups, so methimazole pretreatment did not affect 1-year success.
Randomized trial in Graves' disease comparing radioiodine alone versus methimazole pretreatment then radioiodine: cure rates and 1-year outcomes were similar between groups, so methimazole pretreatment did not affect 1-year success.
Randomized trial in Graves' disease comparing radioiodine alone versus methimazole pretreatment then radioiodine: cure rates and 1-year outcomes were similar between groups, so methimazole pretreatment did not affect 1-year success.
Randomized comparison of two fixed radioactive‑iodine doses in drug‑resistant Graves' disease showing the higher 370 MBq dose produced substantially greater overall treatment response but higher rates of hypothyroidism.
Randomized comparison of two fixed radioactive‑iodine doses in drug‑resistant Graves' disease showing the higher 370 MBq dose produced substantially greater overall treatment response but higher rates of hypothyroidism.
Prospective study of CT‑guided iodine‑125 brachytherapy for bilateral lung metastases from colorectal cancer showed high procedural success, acceptable safety, improved local control and significantly longer overall survival versus symptomatic care.
Randomized trial comparing 131I-labeled Lipiodol versus chemoembolization for HCC: survival and tumor response were similar but 131I-Lipiodol had markedly better tolerance.
Randomized trial comparing 131I-labeled Lipiodol versus chemoembolization for HCC: survival and tumor response were similar but 131I-Lipiodol had markedly better tolerance.
Randomized prospective study found adding I-125 brachytherapy to chemotherapy improved local control, response rate, and progression-free survival vs chemotherapy alone in locally recurrent stage III NSCLC.
COMS ancillary QoL study comparing I-125 brachytherapy vs enucleation: brachytherapy patients had better driving and peripheral vision for up to 1–2 years but were more likely to have persistent anxiety; differences largely diminished by 3–5 years.
COMS ancillary QoL study comparing I-125 brachytherapy vs enucleation: brachytherapy patients had better driving and peripheral vision for up to 1–2 years but were more likely to have persistent anxiety; differences largely diminished by 3–5 years.
COMS ancillary QoL study comparing I-125 brachytherapy vs enucleation: brachytherapy patients had better driving and peripheral vision for up to 1–2 years but were more likely to have persistent anxiety; differences largely diminished by 3–5 years.
Iodine-125 plaque radiotherapy controlled tumors with high eye preservation but caused some radiation-related eye problems and metastases.
Iodine-125 plaque radiotherapy controlled tumors with high eye preservation but caused some radiation-related eye problems and metastases.
Iodine-125 plaque radiotherapy controlled tumors with high eye preservation but caused some radiation-related eye problems and metastases.
Rapid injection of iodinated contrast (1.75 g iodine/s) produced higher aortic attenuation and better visualization of the Adamkiewicz artery on 64-row CT.
Rapid injection of iodinated contrast (1.75 g iodine/s) produced higher aortic attenuation and better visualization of the Adamkiewicz artery on 64-row CT.
Preparation with rhTSH or L-thyroxine withdrawal resulted in similar ablation rates with low-activity I-131; rhTSH avoids hypothyroidism.
Preparation with rhTSH or L-thyroxine withdrawal resulted in similar ablation rates with low-activity I-131; rhTSH avoids hypothyroidism.
Randomized trial in postoperative thyroid cancer patients showing hydrochlorothiazide increased 24 h 131I uptake and augmented absorbed 131I dose of thyroid remnant.
Randomized trial in postoperative thyroid cancer patients showing hydrochlorothiazide increased 24 h 131I uptake and augmented absorbed 131I dose of thyroid remnant.
Large randomized trial found no significant difference in overall mortality or melanoma-specific mortality between I-125 brachytherapy and enucleation for choroidal melanoma.
Randomized comparison of fixed versus calculated 131I activity for Graves' hyperthyroidism showed higher overall success with standard activity; success correlated strongly with absorbed thyroid dose and was influenced by thyroid size.
Randomized comparison of fixed versus calculated 131I activity for Graves' hyperthyroidism showed higher overall success with standard activity; success correlated strongly with absorbed thyroid dose and was influenced by thyroid size.
Randomized comparison of fixed versus calculated 131I activity for Graves' hyperthyroidism showed higher overall success with standard activity; success correlated strongly with absorbed thyroid dose and was influenced by thyroid size.
rhTSH given before 131I therapy improved tracheal cross-sectional area and inspiratory flow at 12 months compared with placebo, indicating reduced tracheal compression after treatment.
rhTSH given before 131I therapy improved tracheal cross-sectional area and inspiratory flow at 12 months compared with placebo, indicating reduced tracheal compression after treatment.
rhTSH given before 131I therapy improved tracheal cross-sectional area and inspiratory flow at 12 months compared with placebo, indicating reduced tracheal compression after treatment.
Randomized trial showing charged particle therapy produced better long-term local tumor control, higher eye preservation, and longer disease-free survival than iodine-125 plaque therapy for ocular melanoma.
Intrahepatic iodine-125 implantation after HCC resection preserved T-cell levels and increased Th1 cytokines (IL-12, IFN-γ) compared with control.
Intrahepatic iodine-125 implantation after HCC resection preserved T-cell levels and increased Th1 cytokines (IL-12, IFN-γ) compared with control.
Intrahepatic iodine-125 implantation after HCC resection preserved T-cell levels and increased Th1 cytokines (IL-12, IFN-γ) compared with control.
Compared half-dose levothyroxine vs full withdrawal before I-131 scanning: full withdrawal reached target TSH far more often but caused greater biochemical disturbances, with no clinical score advantage.
Compared half-dose levothyroxine vs full withdrawal before I-131 scanning: full withdrawal reached target TSH far more often but caused greater biochemical disturbances, with no clinical score advantage.
Compared half-dose levothyroxine vs full withdrawal before I-131 scanning: full withdrawal reached target TSH far more often but caused greater biochemical disturbances, with no clinical score advantage.
Randomized trial comparing 60 vs 100 mCi 131I for remnant ablation in low-risk DTC found no significant differences in early remission, thyroglobulin levels, or need for re-ablation.
Randomized trial comparing 60 vs 100 mCi 131I for remnant ablation in low-risk DTC found no significant differences in early remission, thyroglobulin levels, or need for re-ablation.
Randomized trial comparing 60 vs 100 mCi 131I for remnant ablation in low-risk DTC found no significant differences in early remission, thyroglobulin levels, or need for re-ablation.
Randomized trial showing charged particle therapy produced better long-term local tumor control, higher eye preservation, and longer disease-free survival than iodine-125 plaque therapy for ocular melanoma.
Randomized trial showing charged particle therapy produced better long-term local tumor control, higher eye preservation, and longer disease-free survival than iodine-125 plaque therapy for ocular melanoma.
Analysis of recurrent glioblastoma specimens showed that adjunctive iodine-125 brachytherapy markedly reduced tumor cell proliferation and adverse histological features compared with controls.
Analysis of recurrent glioblastoma specimens showed that adjunctive iodine-125 brachytherapy markedly reduced tumor cell proliferation and adverse histological features compared with controls.
Analysis of recurrent glioblastoma specimens showed that adjunctive iodine-125 brachytherapy markedly reduced tumor cell proliferation and adverse histological features compared with controls.
Large randomized multicenter study of I-125 plaque brachytherapy showing low rates of local failure and enucleation at 5 years.
Large randomized multicenter study of I-125 plaque brachytherapy showing low rates of local failure and enucleation at 5 years.
Lower-iodine contrast plus 55 keV virtual monochromatic images provided equal-or-better CTA image quality while markedly lowering radiation and iodine exposure.
Randomized pediatric CT study found low-concentration contrast + low tube voltage (80 kVp) reduced iodine load (~37%) and radiation dose while maintaining comparable image quality.
Using 80 kVp low-iodine contrast protocol with IMR in CABG patients reduced radiation and iodine load and improved image quality for aorta, left ventricle and venous grafts.
Randomized whole-body CTA trial showing that low tube voltage with low-concentration contrast reduces iodine load and radiation while preserving vascular enhancement and image quality.
Randomized pediatric CT study showing lower-concentration iodinated contrast plus lower tube settings reduces iodine load and radiation while keeping image quality.
Lower-iodine contrast plus 55 keV virtual monochromatic images provided equal-or-better CTA image quality while markedly lowering radiation and iodine exposure.
Lower-iodine contrast plus 55 keV virtual monochromatic images provided equal-or-better CTA image quality while markedly lowering radiation and iodine exposure.
Room-temperature iodinated contrast was noninferior to prewarmed contrast for abdominal CT image quality and produced slightly higher liver attenuation and better comfort.
Lower-iodine contrast plus 55 keV virtual monochromatic images provided equal-or-better CTA image quality while markedly lowering radiation and iodine exposure.
In this small randomized pilot trial, ear packing with BIPP produced no clear benefit versus no packing for symptoms or hearing at follow-up.
In this small randomized pilot trial, ear packing with BIPP produced no clear benefit versus no packing for symptoms or hearing at follow-up.
In this small randomized pilot trial, ear packing with BIPP produced no clear benefit versus no packing for symptoms or hearing at follow-up.
In this small randomized pilot trial, ear packing with BIPP produced no clear benefit versus no packing for symptoms or hearing at follow-up.
Neonatal thyroid screening showed no increase in congenital hypothyroidism and comparable T4 levels after maternal HSG with oil- versus water-based iodinated contrast.
Neonatal thyroid screening showed no increase in congenital hypothyroidism and comparable T4 levels after maternal HSG with oil- versus water-based iodinated contrast.
Neonatal thyroid screening showed no increase in congenital hypothyroidism and comparable T4 levels after maternal HSG with oil- versus water-based iodinated contrast.
A low-concentration/low-voltage iodinated-contrast protocol produced comparable coronary CT image quality and may improve safety without loss of diagnostic information.
A low-concentration/low-voltage iodinated-contrast protocol produced comparable coronary CT image quality and may improve safety without loss of diagnostic information.
Randomized pediatric CT study showing lower-concentration iodinated contrast plus lower tube settings reduces iodine load and radiation while keeping image quality.
Analysis in STEMI patients showing that diagnostic iodinated contrast injections can mechanically reduce thrombotic stenosis, especially with prior eptifibatide.
Using a lower-iodine concentration contrast agent produced image quality similar to a higher-iodine agent and had slightly fewer adverse events.
Randomized double-blind trial comparing two iodinated contrast agents for head CT found no difference in safety or diagnostic performance.
Iobitridol had comparable safety and diagnostic efficacy to reference iohexol in coronary angiography with few adverse events.
Randomized double-blind trial comparing two iodinated contrast agents for head CT found no difference in safety or diagnostic performance.
Comparative study in children testing an iodinated contrast agent (iobitridol 350) versus iopamidol 370 for angiocardiography; no differences in image quality or safety.
Compared two corticosteroid + H2 antagonist pretreatment schedules before iodinated contrast; no significant difference in preventing adverse reactions.
Assessed whether povidone-iodine skin prep affects infants' thyroid hormones after cardiac surgery; cardiopulmonary bypass had larger effects than antiseptic used.
Assessed whether povidone-iodine skin prep affects infants' thyroid hormones after cardiac surgery; cardiopulmonary bypass had larger effects than antiseptic used.
Crossover trial showed higher iodinated contrast concentration (iomeprol 400 vs 300 mg I/mL) improved arterial-phase lesion enhancement and detection in liver CT.
Crossover trial showed higher iodinated contrast concentration (iomeprol 400 vs 300 mg I/mL) improved arterial-phase lesion enhancement and detection in liver CT.
Crossover trial showed higher iodinated contrast concentration (iomeprol 400 vs 300 mg I/mL) improved arterial-phase lesion enhancement and detection in liver CT.
Randomized comparison in patients with renal impairment showed fewer creatinine rises after angiography with iodixanol than with iohexol.
Randomized comparison in patients with renal impairment showed fewer creatinine rises after angiography with iodixanol than with iohexol.
Single-dose phase‑1 study in healthy men showing rapid plasma peaks, renal excretion of the iodinated agent, and mostly mild transient adverse events.
Single-dose phase‑1 study in healthy men showing rapid plasma peaks, renal excretion of the iodinated agent, and mostly mild transient adverse events.
Iobitridol had comparable safety and diagnostic efficacy to reference iohexol in coronary angiography with few adverse events.
Prospective double-blind randomized multicenter trial comparing two low-osmolar iodinated contrast agents for abdominal CT focusing on adverse events and diagnostic efficacy.
Single-dose phase‑1 study in healthy men showing rapid plasma peaks, renal excretion of the iodinated agent, and mostly mild transient adverse events.
Randomized comparison of contrast injection protocols found high-concentration/high-flow iodine produced higher vessel attenuation and better image quality but more artifacts.
Randomized comparison of contrast injection protocols found high-concentration/high-flow iodine produced higher vessel attenuation and better image quality but more artifacts.
Randomized comparison of contrast injection protocols found high-concentration/high-flow iodine produced higher vessel attenuation and better image quality but more artifacts.
Randomized whole-body CTA trial showing that low tube voltage with low-concentration contrast reduces iodine load and radiation while preserving vascular enhancement and image quality.
Randomized trial showing that halving contrast volume and using low tube voltage (80 kV) yields higher arterial attenuation and substantially lower radiation dose with good image quality.
A BMI-based dual-energy CT protocol reduced radiation dose and iodinated contrast volume without degrading image quality or diagnostic accuracy.
Randomized trial showing that halving contrast volume and using low tube voltage (80 kV) yields higher arterial attenuation and substantially lower radiation dose with good image quality.
Randomized pediatric CT study found low-concentration contrast + low tube voltage (80 kVp) reduced iodine load (~37%) and radiation dose while maintaining comparable image quality.
Randomized pediatric CT study found low-concentration contrast + low tube voltage (80 kVp) reduced iodine load (~37%) and radiation dose while maintaining comparable image quality.
Prospective randomized study indicating that larger amounts of iodinated contrast correlate with greater short-term rises in serum creatinine; CO2 with small added ioxaglate associated with lower renal risk than larger ioxaglate doses alone.
Use of iodinated contrast (iohexol) was associated with increases in creatinine and a measurable rate of contrast-induced nephropathy compared with gadodiamide mixed with a small amount of iohexol.
In ICU patients receiving ≥100 mL iodinated contrast, theophylline reduced incidence of contrast-induced nephropathy more than acetylcysteine.
Prospective randomized study indicating that larger amounts of iodinated contrast correlate with greater short-term rises in serum creatinine; CO2 with small added ioxaglate associated with lower renal risk than larger ioxaglate doses alone.
Prospective randomized study indicating that larger amounts of iodinated contrast correlate with greater short-term rises in serum creatinine; CO2 with small added ioxaglate associated with lower renal risk than larger ioxaglate doses alone.
Compared two epidural injection approaches using iodinated contrast; the parasagittal interlaminar (PIL) approach produced more anterior contrast spread and shorter fluoroscopy time, pain relief was similar.
Compared two epidural injection approaches using iodinated contrast; the parasagittal interlaminar (PIL) approach produced more anterior contrast spread and shorter fluoroscopy time, pain relief was similar.
Compared two epidural injection approaches using iodinated contrast; the parasagittal interlaminar (PIL) approach produced more anterior contrast spread and shorter fluoroscopy time, pain relief was similar.
Compared two epidural injection approaches using iodinated contrast; the parasagittal interlaminar (PIL) approach produced more anterior contrast spread and shorter fluoroscopy time, pain relief was similar.
Randomized trial comparing high (400 mg/ml) vs lower (300 mg/ml) iodinated contrast concentrations; overall patient-reported discomfort was very low with only a small difference in pain favoring lower concentration.
Randomized trial comparing high (400 mg/ml) vs lower (300 mg/ml) iodinated contrast concentrations; overall patient-reported discomfort was very low with only a small difference in pain favoring lower concentration.
Randomized trial showing dual-energy CT allowed >50% reduction in iodinated contrast volume (35 mL vs 80 mL) with comparable diagnostic interpretability and similar CNR/SNR after adjustment.
Randomized trial showing dual-energy CT allowed >50% reduction in iodinated contrast volume (35 mL vs 80 mL) with comparable diagnostic interpretability and similar CNR/SNR after adjustment.
Prospective randomized study in normal-weight patients showing CCTA at 70 kVp with 28 mL iodinated contrast and low injection rate produced diagnostic image quality similar to standard protocol (40 mL).
Prospective randomized study in normal-weight patients showing CCTA at 70 kVp with 28 mL iodinated contrast and low injection rate produced diagnostic image quality similar to standard protocol (40 mL).
Double-blind randomized trial in diabetics with critical limb ischemia showing Iodixanol 270 caused substantially less intra-arterial pain and heat sensation than Ioversol 320.
Double-blind randomized trial in diabetics with critical limb ischemia showing Iodixanol 270 caused substantially less intra-arterial pain and heat sensation than Ioversol 320.
Double-blind randomized trial in diabetics with critical limb ischemia showing Iodixanol 270 caused substantially less intra-arterial pain and heat sensation than Ioversol 320.
Phase III randomized non-inferiority trial in CKD stage IIIb patients showed oral hydration was non-inferior to IV bicarbonate hydration to prevent post-contrast acute kidney injury after CT with iodinated contrast.
Phase III randomized non-inferiority trial in CKD stage IIIb patients showed oral hydration was non-inferior to IV bicarbonate hydration to prevent post-contrast acute kidney injury after CT with iodinated contrast.
Phase III randomized non-inferiority trial in CKD stage IIIb patients showed oral hydration was non-inferior to IV bicarbonate hydration to prevent post-contrast acute kidney injury after CT with iodinated contrast.
Small randomized study showing transient decreases in plasma acetyl- and butyrylcholinesterase activity after injection of iodinated contrast agents.
Small randomized study showing transient decreases in plasma acetyl- and butyrylcholinesterase activity after injection of iodinated contrast agents.
Multicenter randomized double-blind trial showing fenoldopam did not reduce contrast-induced nephropathy after iodinated contrast exposure.
Multicenter randomized double-blind trial showing fenoldopam did not reduce contrast-induced nephropathy after iodinated contrast exposure.
Per-protocol analysis of a randomized trial showing iodinated antimicrobial drapes reduced intraoperative bacterial contamination in knee arthroplasty.
Per-protocol analysis of a randomized trial showing iodinated antimicrobial drapes reduced intraoperative bacterial contamination in knee arthroplasty.
Randomized non-inferiority trial showing no prophylactic IV hydration was non-inferior and cost-saving versus hydration for preventing contrast-induced nephropathy.
Randomized non-inferiority trial showing no prophylactic IV hydration was non-inferior and cost-saving versus hydration for preventing contrast-induced nephropathy.
Randomized trial in HIV-positive patients showing sockets treated with an iodoform-containing paste healed faster than sutured-only sockets.
Rehydration before contrast CT did not change the incidence of acute adverse reactions to iodinated contrast compared with control.
Rehydration before contrast CT did not change the incidence of acute adverse reactions to iodinated contrast compared with control.
Rehydration before contrast CT did not change the incidence of acute adverse reactions to iodinated contrast compared with control.
A BMI-based dual-energy CT protocol reduced radiation dose and iodinated contrast volume without degrading image quality or diagnostic accuracy.
In 255 patients, deep learning image reconstruction plus high-concentration iodinated contrast enabled a double-low protocol (lower radiation and lower contrast volume) while maintaining or improving image quality.
A BMI-based dual-energy CT protocol reduced radiation dose and iodinated contrast volume without degrading image quality or diagnostic accuracy.
Iodoform+calendula-coated silk sutures showed significantly less bacterial colonization than uncoated sutures.
No difference in efficacy or patient tolerance between Merocel tampons and BIPP (iodoform-containing paste) for severe epistaxis.
In children needing pulpectomy, an iodoform paste showed non-inferior 24‑month success versus a calcium hydroxide/iodoform paste.
Tinidazole-dexamethasone-iodoform intracanal paste reduced interappointment emergencies and showed good long-term results versus formocresol.
Randomized comparison in children of two root canal filling pastes (iodoform-based vs Calen®/ZO [calcium hydroxide/ZnO]); both had high clinical/radiographic success at 12 months.
Randomized comparison in children of two root canal filling pastes (iodoform-based vs Calen®/ZO [calcium hydroxide/ZnO]); both had high clinical/radiographic success at 12 months.
Randomized comparison in children of two root canal filling pastes (iodoform-based vs Calen®/ZO [calcium hydroxide/ZnO]); both had high clinical/radiographic success at 12 months.
Chlorhexidine and hydrogen peroxide irrigation reduced postoperative pain and swelling after molar extraction; povidone‑iodine did not show those benefits compared with control.
Preoperative povidone-iodine vaginal cleansing reduced postoperative pain, inflammatory marker (CRP) and analgesic need after elective cesarean.
Randomized comparison of three root canal filling materials (Endoflas, zinc oxide eugenol, Metapex) in primary molars over 18 months; Metapex (a calcium hydroxide/iodoform product) showed 100% success while the other two showed 93.3% success; differences were not statistically significant.
Randomized comparison of three root canal filling materials (Endoflas, zinc oxide eugenol, Metapex) in primary molars over 18 months; Metapex (a calcium hydroxide/iodoform product) showed 100% success while the other two showed 93.3% success; differences were not statistically significant.
In children needing pulpectomy, an iodoform paste showed non-inferior 24‑month success versus a calcium hydroxide/iodoform paste.
In children (5–9 y), Portland cement combined with radiopacifiers used for pulpotomy had 100% clinical and radiographic success over 24 months.
Iso-osmolar (iodixanol) and low-osmolar (iopamidol) iodinated contrasts had similar diagnostic accuracy and image quality, but iodixanol caused less moderate-to-severe flushing.
Iso-osmolar (iodixanol) and low-osmolar (iopamidol) iodinated contrasts had similar diagnostic accuracy and image quality, but iodixanol caused less moderate-to-severe flushing.
Automated CYDAR fusion imaging reduced radiation metrics but used more iodinated contrast during aorto-iliac endovascular procedures.
Sixteen weeks of iodinated glycerol did not improve pulmonary function, symptoms, or sputum properties compared with placebo in chronic bronchitis.
Sixteen weeks of iodinated glycerol did not improve pulmonary function, symptoms, or sputum properties compared with placebo in chronic bronchitis.
PRGF treated dry socket led to faster bone coverage and reduced inflammation and bad breath compared with Alvogyl.
PRGF treated dry socket led to faster bone coverage and reduced inflammation and bad breath compared with Alvogyl.
PRGF treated dry socket led to faster bone coverage and reduced inflammation and bad breath compared with Alvogyl.
In primary molar pulpectomies, ZOE and the modified zinc‑oxide/iodoform/calcium‑hydroxide compound showed high clinical/radiographic success at 6 and 12 months, with different resorption profiles among materials.
In primary molar pulpectomies, ZOE and the modified zinc‑oxide/iodoform/calcium‑hydroxide compound showed high clinical/radiographic success at 6 and 12 months, with different resorption profiles among materials.
In primary molar pulpectomies, ZOE and the modified zinc‑oxide/iodoform/calcium‑hydroxide compound showed high clinical/radiographic success at 6 and 12 months, with different resorption profiles among materials.
In high-risk PCI patients given iodinated contrast, IV prostaglandin E1 reduced the incidence of contrast-induced nephropathy versus control hydration alone.
In patients undergoing coronary angiography with iodinated contrast, nebivolol pretreatment showed a nonsignificant trend toward less creatinine rise and slightly lower CIN incidence versus controls.
Large randomized trial comparing two iodine-based contrast agents (low-osmolar vs iso-osmolar) in high-risk patients; measured contrast-induced nephropathy (CIN), dialysis, and 30-day outcomes.
CO2-guided angioplasty reduced iodinated contrast exposure and had a low incidence of contrast-induced nephropathy but notable CO2-related complications.
In children with normal renal function, iobitridol was noninferior to iodixanol for creatinine clearance change and rates of contrast-induced nephropathy were not significantly different.
CO2-guided angioplasty reduced iodinated contrast exposure and had a low incidence of contrast-induced nephropathy but notable CO2-related complications.
CO2-guided angioplasty reduced iodinated contrast exposure and had a low incidence of contrast-induced nephropathy but notable CO2-related complications.
Iobitridol had comparable safety and diagnostic efficacy to reference iohexol in coronary angiography with few adverse events.
In 180 patients, prone imaging improved polyp detection but adding oral iodinated contrast did not significantly increase polyp detection.
In 180 patients, prone imaging improved polyp detection but adding oral iodinated contrast did not significantly increase polyp detection.
In 180 patients, prone imaging improved polyp detection but adding oral iodinated contrast did not significantly increase polyp detection.
Randomized study in 74 patients comparing CO2 vs iodinated contrast for PICC placement: iodinated contrast had higher placement success, with similar procedure times and no adverse events reported for CO2.
Randomized study in 74 patients comparing CO2 vs iodinated contrast for PICC placement: iodinated contrast had higher placement success, with similar procedure times and no adverse events reported for CO2.
Randomized study in 74 patients comparing CO2 vs iodinated contrast for PICC placement: iodinated contrast had higher placement success, with similar procedure times and no adverse events reported for CO2.
Review of 133 stroke patients found numerical outcome advantages favoring iso-osmolal iodixanol over low-osmolal contrast for several endpoints, but results were inconclusive.
Review of 133 stroke patients found numerical outcome advantages favoring iso-osmolal iodixanol over low-osmolal contrast for several endpoints, but results were inconclusive.
Review of 133 stroke patients found numerical outcome advantages favoring iso-osmolal iodixanol over low-osmolal contrast for several endpoints, but results were inconclusive.
Bolus-tracking in 75 patients showed nephrographic phase onset varies with contrast volume and injection rate; onset times differed across groups (mean 75–103 s).
Bolus-tracking in 75 patients showed nephrographic phase onset varies with contrast volume and injection rate; onset times differed across groups (mean 75–103 s).
Bolus-tracking in 75 patients showed nephrographic phase onset varies with contrast volume and injection rate; onset times differed across groups (mean 75–103 s).
Compared dilute iodinated oral contrast with other low-attenuation agents for abdominal-pelvic CT; PEG performed best for bowel distention and transit.
Compared dilute iodinated oral contrast with other low-attenuation agents for abdominal-pelvic CT; PEG performed best for bowel distention and transit.
Compared dilute iodinated oral contrast with other low-attenuation agents for abdominal-pelvic CT; PEG performed best for bowel distention and transit.
Compared two retrograde venography techniques using iodinated contrast during TIPS; balloon occlusion markedly improved portal vein visualization and portogram quality and reduced procedure time.
Compared two retrograde venography techniques using iodinated contrast during TIPS; balloon occlusion markedly improved portal vein visualization and portogram quality and reduced procedure time.
Compared two retrograde venography techniques using iodinated contrast during TIPS; balloon occlusion markedly improved portal vein visualization and portogram quality and reduced procedure time.
Triple-blind RCT testing 5% povidone-iodine applied to the ear before tympanoplasty found no short-term hearing (bone conduction) impairment at one month.
Randomized trial comparing Alvogyl (contains iodoform) versus black seed mixture and saline for dry socket; black seed produced fastest pain relief and Alvogyl improved pain gradually.
Clinical study found that irrigation of extraction sockets with 1% povidone-iodine stopped bleeding more often than saline.
Timed intraoperative iodine irrigation (0.33% povidone-iodine equivalent) during cataract surgery greatly reduced cultivable bacteria and bacterial DNA on the ocular surface without adverse epithelial or endothelial effects.
Timed intraoperative iodine irrigation (0.33% povidone-iodine equivalent) during cataract surgery greatly reduced cultivable bacteria and bacterial DNA on the ocular surface without adverse epithelial or endothelial effects.
In patients receiving iodinated contrast, NGAL rose early (8 h) and predicted contrast-induced nephropathy while serum creatinine rose later (24 h).
In patients receiving iodinated contrast, NGAL rose early (8 h) and predicted contrast-induced nephropathy while serum creatinine rose later (24 h).
In patients receiving iodinated contrast, NGAL rose early (8 h) and predicted contrast-induced nephropathy while serum creatinine rose later (24 h).
In infertile women, a positive ultrasound contrast (Infoson) provided better tubal patency diagnoses than saline and matched iodinated HSG accuracy.
Povidone-iodine pleurodesis had similar complete response rates to bleomycin and is a cost-effective option.
Prospective randomized comparison of 5% povidone-iodine vs tetracycline for pleurodesis in malignant pleural effusion: similar high overall success rates with no significant difference.
Povidone-iodine pleurodesis had similar complete response rates to bleomycin and is a cost-effective option.
Preoperative povidone-iodine 5% significantly reduced conjunctival bacterial counts; 1% was not effective; chloramphenicol also reduced counts.
Preoperative povidone-iodine 5% significantly reduced conjunctival bacterial counts; 1% was not effective; chloramphenicol also reduced counts.
Povidone-iodine pleurodesis reduced drainage time and hospital stay versus surveillance with acceptable complications.
Povidone-iodine pleurodesis reduced drainage time and hospital stay versus surveillance with acceptable complications.
Use of povidone-iodine dressings showed fewer groin wound infections numerically but the difference was not statistically significant.
Both Lavasept and 1.25% PVP-iodine reduced conjunctival bacterial counts, with Lavasept reducing colonies more than PVP-iodine.
Irrigation with povidone-iodine did not reduce overall 30-day SSI and was associated with higher superficial incisional SSI compared to saline.
Irrigation with povidone-iodine did not reduce overall 30-day SSI and was associated with higher superficial incisional SSI compared to saline.
Irrigating spinal fusion wounds with diluted povidone-iodine reduced infections and did not harm wound healing, bone fusion, or clinical recovery.
Irrigating spinal fusion wounds with diluted povidone-iodine reduced infections and did not harm wound healing, bone fusion, or clinical recovery.
Irrigating spinal fusion wounds with diluted povidone-iodine reduced infections and did not harm wound healing, bone fusion, or clinical recovery.
Applying 5% povidone-iodine eye drops caused slowing and short pauses in breathing in many children under general anesthesia.
Postoperative irrigation with povidone-iodine reduced jaw opening limitation (trismus); 3% concentration was most effective at reducing facial swelling.
Low-concentration povidone-iodine irrigation during third molar extraction reduced postoperative swelling and trismus but did not significantly change pain; higher patient satisfaction reported for the PVI-treated side.
Using povidone-iodine as an irrigant after third-molar removal was associated with more pain, alveolar osteitis, swelling, and trismus compared with chlorhexidine.
Postoperative irrigation with povidone-iodine reduced jaw opening limitation (trismus); 3% concentration was most effective at reducing facial swelling.
Irrigating subcutaneous tissue with 10% povidone-iodine reduced superficial incisional wound infections compared with saline irrigation.
Use of povidone-iodine soaked wound wicks did not reduce post-appendectomy wound infections and had a numerically higher infection rate than subcuticular closure.
Vaginal cleansing with 10% povidone-iodine before cesarean had higher wound infection rates than 4% chlorhexidine and similar rates of endometritis and fever.
In ED patients with simple traumatic wounds, cleansing skin with povidone-iodine did not reduce subsequent wound infection rates compared with control.
Applying povidone-iodine gel to subcutaneous tissue and sealing the wound markedly reduced postoperative wound infections compared with standard open treatment in high-risk hepatobiliary surgery patients.
Compared shower+saline skin prep vs traditional scrub with povidone-iodine/chlorhexidine in outpatient plastic surgery; no wound infections occurred in either group.
A single-application povidone-iodine applicator used much less solution and was non-inferior to conventional sterilization for wound infection after abdominal surgery.
Vaginal cleansing with 10% povidone-iodine before cesarean had higher wound infection rates than 4% chlorhexidine and similar rates of endometritis and fever.
Vaginal cleansing with 10% povidone-iodine before cesarean had higher wound infection rates than 4% chlorhexidine and similar rates of endometritis and fever.
Mixing povidone-iodine 10% with levofloxacin 0.5% before cataract surgery reduced positive aqueous cultures compared with povidone-iodine alone.
Regular oropharyngeal rinsing with povidone-iodine in ventilated head-trauma patients markedly reduced ventilator-associated pneumonia compared with saline or standard care.
Regular oropharyngeal rinsing with povidone-iodine in ventilated head-trauma patients markedly reduced ventilator-associated pneumonia compared with saline or standard care.
Randomized trial found no infectious events in either group and minimal differences in symptom scores; povidone-iodine suppository was safe.
Randomized trial found no infectious events in either group and minimal differences in symptom scores; povidone-iodine suppository was safe.
Applying povidone-iodine to the incision after skin closure did not reduce surgical site infections compared with no application.
Applying povidone-iodine to the incision after skin closure did not reduce surgical site infections compared with no application.
In patients with malignant pleural effusion, povidone-iodine produced similar pleurodesis success and complications compared with bleomycin.
In patients with malignant pleural effusion, povidone-iodine produced similar pleurodesis success and complications compared with bleomycin.
Both PVP‑I 0.1% and boric acid 0.5% plus SRP improved periodontitis; boric acid produced greater reductions in gum inflammation and bleeding.
In peri-implant mucositis, 2% and 10% povidone-iodine adjunctive irrigation improved gingival and bleeding indices more than 0.1%.
In peri-implant mucositis, 2% and 10% povidone-iodine adjunctive irrigation improved gingival and bleeding indices more than 0.1%.
Postoperative povidone-iodine soaks did not improve outcomes after operative drainage of hand abscesses.
Postoperative povidone-iodine soaks did not improve outcomes after operative drainage of hand abscesses.
Using a povidone-iodine paint alone for abdominal preoperative skin prep was equivalent to scrub-and-paint for preventing wound infections.
Sixty patients with external fixators had dressings with either diluted povidone-iodine or saline; infection rates were similar between groups.
Vaginal irrigation with povidone-iodine before cesarean reduced postpartum endometritis, especially in women in labor or with ruptured membranes.
Three hundred gynecologic oncology patients had subcutaneous irrigation with saline, saline + povidone-iodine, or saline + rifampicin; no difference in incisional SSI between groups.
In 300 cesarean patients randomized to saline, rifampicin, or 10% povidone-iodine irrigation, povidone-iodine did not reduce incisional surgical site infections.
Irrigating the distal urethra with 2% povidone-iodine before cystoscopy markedly reduced post-procedure urinary tract infections.
Patients receiving preoperative vaginal antisepsis with povidone-iodine or chlorhexidine reported similar short-term vaginal symptoms.
Sequential skin cleansing with chlorhexidine followed by two povidone-iodine washes eliminated detectable skin bacterial growth in neurosurgery patients.
In patients with venous leg ulcers, topical povidone-iodine with compression improved healing rates versus povidone-iodine without compression; systemic antibiotics had similar healing but higher relapse.
In patients with venous leg ulcers, topical povidone-iodine with compression improved healing rates versus povidone-iodine without compression; systemic antibiotics had similar healing but higher relapse.
In patients with venous leg ulcers, topical povidone-iodine with compression improved healing rates versus povidone-iodine without compression; systemic antibiotics had similar healing but higher relapse.
In patients with venous leg ulcers, topical povidone-iodine with compression improved healing rates versus povidone-iodine without compression; systemic antibiotics had similar healing but higher relapse.
Healthy volunteers had antiseptics applied; chlorhexidine was removed by saline gauze while iodine film remained on skin and both reduced bacteria counts.
Healthy volunteers had antiseptics applied; chlorhexidine was removed by saline gauze while iodine film remained on skin and both reduced bacteria counts.
Among randomized full-term neonates, povidone-iodine prophylaxis was associated with higher rates of ophthalmia neonatorum and sterile conjunctivitis compared with tetracycline.
Among randomized full-term neonates, povidone-iodine prophylaxis was associated with higher rates of ophthalmia neonatorum and sterile conjunctivitis compared with tetracycline.
Large randomized trial found no significant difference in 30-day cesarean surgical site infection rates between chlorhexidine-alcohol and povidone-iodine skin preparations.
Large randomized equivalence trial found hand-rubbing with 75% aqueous alcohol was as effective as traditional hand-scrubbing with antiseptic soap containing 4% povidone iodine or 4% chlorhexidine in preventing 30-day surgical site infections, with better tolerance and compliance for hand-rubbing.
In 24 neonates with major omphalocoele, topical povidone-iodine and Acacia paste had similar clinical outcomes; no thyroid test changes were observed with povidone-iodine.
In 24 neonates with major omphalocoele, topical povidone-iodine and Acacia paste had similar clinical outcomes; no thyroid test changes were observed with povidone-iodine.
Randomized trial comparing 2% alcoholic chlorhexidine vs 5% povidone-iodine alcohol for skin antisepsis before perineural catheter placement; chlorhexidine reduced catheter colonisation.
Randomized trial comparing 2% alcoholic chlorhexidine vs 5% povidone-iodine alcohol for skin antisepsis before perineural catheter placement; chlorhexidine reduced catheter colonisation.
Randomized trial comparing 2% alcoholic chlorhexidine vs 5% povidone-iodine alcohol for skin antisepsis before perineural catheter placement; chlorhexidine reduced catheter colonisation.
Comparative study in children testing an iodinated contrast agent (iobitridol 350) versus iopamidol 370 for angiocardiography; no differences in image quality or safety.
Randomized trial of preoperative skin preparation before elective cesarean: chlorhexidine groups showed better wound outcomes and comfort than povidone-iodine.
Randomized trial of preoperative skin preparation before elective cesarean: chlorhexidine groups showed better wound outcomes and comfort than povidone-iodine.
Randomized trial of preoperative skin preparation before elective cesarean: chlorhexidine groups showed better wound outcomes and comfort than povidone-iodine.
Randomized trial in gingivitis patients showing that a 2-minute rinse with 7.5% povidone-iodine before ultrasonic scaling markedly reduced incidence and magnitude of oral bacteraemia.
Randomized trial in gingivitis patients showing that a 2-minute rinse with 7.5% povidone-iodine before ultrasonic scaling markedly reduced incidence and magnitude of oral bacteraemia.
Randomized trial in gingivitis patients showing that a 2-minute rinse with 7.5% povidone-iodine before ultrasonic scaling markedly reduced incidence and magnitude of oral bacteraemia.
Prospective randomized clinical trial in third-molar surgery showing low-concentration (0.5%) povidone-iodine used as irrigant reduced postoperative swelling.
Low-concentration povidone-iodine irrigation during third molar extraction reduced postoperative swelling and trismus but did not significantly change pain; higher patient satisfaction reported for the PVI-treated side.
Chlorhexidine and hydrogen peroxide irrigation reduced postoperative pain and swelling after molar extraction; povidone‑iodine did not show those benefits compared with control.
Prospective randomized clinical trial in third-molar surgery showing low-concentration (0.5%) povidone-iodine used as irrigant reduced postoperative swelling.
Prospective randomized comparison of 5% povidone-iodine vs tetracycline for pleurodesis in malignant pleural effusion: similar high overall success rates with no significant difference.
Prospective randomized comparison of 5% povidone-iodine vs tetracycline for pleurodesis in malignant pleural effusion: similar high overall success rates with no significant difference.
Randomized study showing a single preoperative 10% povidone-iodine shower 2 hours before elective plastic surgery significantly reduced staphylococcal skin colonization.
Randomized study showing a single preoperative 10% povidone-iodine shower 2 hours before elective plastic surgery significantly reduced staphylococcal skin colonization.
Topical tranexamic acid applied with povidone-iodine in knee replacement increased postoperative hemoglobin and tended to reduce blood loss without more complications.
Topical tranexamic acid applied with povidone-iodine in knee replacement increased postoperative hemoglobin and tended to reduce blood loss without more complications.
Automated CYDAR fusion imaging reduced radiation metrics but used more iodinated contrast during aorto-iliac endovascular procedures.
Automated CYDAR fusion imaging reduced radiation metrics but used more iodinated contrast during aorto-iliac endovascular procedures.
Contrast-enhanced CT was associated with higher AKI rates and worse clinical outcomes on unadjusted analysis, but after adjusting for disease severity there was no significant difference.
Contrast-enhanced CT was associated with higher AKI rates and worse clinical outcomes on unadjusted analysis, but after adjusting for disease severity there was no significant difference.
Contrast-enhanced CT was associated with higher AKI rates and worse clinical outcomes on unadjusted analysis, but after adjusting for disease severity there was no significant difference.
Microbial sealant was equivalent to standard povidone-iodine cleaning plus plain adhesive drape for skin preparation in cardiac surgery; no postoperative wound infections occurred.
Patients reported fewer unpleasant experiences and adverse events with povidone-iodine nasal decolonization compared with mupirocin.
Two double-blind RCTs tested multiple antiseptic rinses including povidone iodine; only the CPC-containing rinse significantly reduced salivary SARS-CoV-2 viral load at 30 min, while povidone iodine did not show a significant effect in these trials.
Randomized trial (n=40 COVID-19 patients) testing four mouthrinses including 0.5% povidone-iodine; primary outcome was reduction in salivary SARS-CoV-2 load at 15 minutes.
Gargling with 0.25% povidone-iodine did not reduce salivary SARS-CoV-2 viral load compared with saline.
Povidone-iodine skin prep had higher Propionibacterium acnes suture contamination than chlorhexidine-alcohol with an adhesive drape.
Povidone-iodine skin prep had higher Propionibacterium acnes suture contamination than chlorhexidine-alcohol with an adhesive drape.
Preoperative povidone-iodine vaginal cleansing reduced postoperative pain, inflammatory marker (CRP) and analgesic need after elective cesarean.
Preoperative povidone-iodine vaginal cleansing reduced postoperative pain, inflammatory marker (CRP) and analgesic need after elective cesarean.
Mouth rinsing/gargling with 0.5%–1% povidone-iodine increased SARS-CoV-2 RT-PCR CT values (indicating lower viral RNA) over 5 days.
A 1% povidone-iodine mouthwash significantly increased salivary SARS-CoV-2 Ct values (reduced salivary viral load) compared with water.
Irrigating the conjunctival sac with 0.5% or 5% povidone-iodine reduced conjunctival bacteria similarly to gentamycin with no safety concerns reported.
Topical ofloxacin reduced conjunctival bacteria and adding preoperative 5% povidone-iodine further reduced conjunctival flora to very low levels; anterior chamber contamination was rare.
Irrigating the conjunctival sac with 0.5% or 5% povidone-iodine reduced conjunctival bacteria similarly to gentamycin with no safety concerns reported.
Washing the biopsy needle with povidone-iodine did not change infection rates after transrectal prostate biopsy.
In children after circumcision, application of wound induction gel resulted in fewer glans scabs and slightly faster wound healing than povidone-iodine application.
In this small pilot RCT povidone‑iodine showed similar wound healing time to honey and paraffin gauze with no statistically significant differences.
Wet silver dressings healed skin wounds faster, reduced dressing changes and pain compared with povidone-iodine dressings.
Sequential intraoperative irrigation including hydrogen peroxide + povidone‑iodine + saline markedly reduced superficial and periprosthetic joint infections versus saline alone after TKA.
Sequential intraoperative irrigation including hydrogen peroxide + povidone‑iodine + saline markedly reduced superficial and periprosthetic joint infections versus saline alone after TKA.
Adding 0.5% povidone‑iodine irrigation to one‑stage periodontal debridement did not improve probing depth reduction at 3 months compared with controls.
Adding 0.5% povidone‑iodine irrigation to one‑stage periodontal debridement did not improve probing depth reduction at 3 months compared with controls.
In patients needing root canal retreatment, using 5% iodine-potassium iodide as a final rinse reduced bacteria more than 2% IKI.
In patients needing root canal retreatment, using 5% iodine-potassium iodide as a final rinse reduced bacteria more than 2% IKI.
In patients needing root canal retreatment, using 5% iodine-potassium iodide as a final rinse reduced bacteria more than 2% IKI.
Brushing the tongue with povidone-iodine or hydrogen peroxide significantly lowered tongue bacterial counts, while benzethonium chloride and water did not.
Brushing the tongue with povidone-iodine or hydrogen peroxide significantly lowered tongue bacterial counts, while benzethonium chloride and water did not.
Brushing the tongue with povidone-iodine or hydrogen peroxide significantly lowered tongue bacterial counts, while benzethonium chloride and water did not.
Preprocedural rinses/irrigation with chlorhexidine, povidone-iodine, or ozone all reduced aerobic and anaerobic microbial counts in dental aerosols, with varying percent reductions by location.
Preprocedural rinses/irrigation with chlorhexidine, povidone-iodine, or ozone all reduced aerobic and anaerobic microbial counts in dental aerosols, with varying percent reductions by location.
Preprocedural rinses/irrigation with chlorhexidine, povidone-iodine, or ozone all reduced aerobic and anaerobic microbial counts in dental aerosols, with varying percent reductions by location.
Applying 10% povidone-iodine in the mouth of ventilated patients reduced oral bacterial counts for at least 3 hours and lowered several tested pathogens without disrupting microbiota balance.
Applying 10% povidone-iodine in the mouth of ventilated patients reduced oral bacterial counts for at least 3 hours and lowered several tested pathogens without disrupting microbiota balance.
Applying 10% povidone-iodine in the mouth of ventilated patients reduced oral bacterial counts for at least 3 hours and lowered several tested pathogens without disrupting microbiota balance.
Preoperative vaginal preparation with 4% chlorhexidine resulted in lower vaginal/cervical culture growth before colpotomy than 2% chlorhexidine or 10% povidone-iodine in patients undergoing laparoscopic hysterectomy.
Preoperative vaginal preparation with 4% chlorhexidine resulted in lower vaginal/cervical culture growth before colpotomy than 2% chlorhexidine or 10% povidone-iodine in patients undergoing laparoscopic hysterectomy.
Preoperative vaginal preparation with 4% chlorhexidine resulted in lower vaginal/cervical culture growth before colpotomy than 2% chlorhexidine or 10% povidone-iodine in patients undergoing laparoscopic hysterectomy.
Periurethral cleansing with povidone-iodine, chlorhexidine, or sterile water showed no statistically significant differences in catheter-associated urinary tract infection rates in this pediatric ICU trial.
Periurethral cleansing with povidone-iodine, chlorhexidine, or sterile water showed no statistically significant differences in catheter-associated urinary tract infection rates in this pediatric ICU trial.
Periurethral cleansing with povidone-iodine, chlorhexidine, or sterile water showed no statistically significant differences in catheter-associated urinary tract infection rates in this pediatric ICU trial.
Tested mupirocin vs povidone-iodine for clearing nasal Staphylococcus aureus in healthcare workers; mupirocin worked better.
DuraPrep plus drape was equivalent to povidone-iodine scrub/paint plus drape for wound contamination prevention, with less drape lift and lower cost for DuraPrep.
Compared PVI twice versus PVI once then chlorhexidine; sequential PVI+CHG reduced bacterial wound contamination more than PVI alone.
Compared 5% povidone-iodine to topical ciprofloxacin and ofloxacin for conjunctival bacterial sterilization; antibiotics (ciprofloxacin) performed better than povidone-iodine.
Tested topical antibiotics versus no drops prior to intravitreal injection, with povidone-iodine applied before injection; povidone-iodine alone produced large reduction in conjunctival bacterial positivity and was as effective as pre-applied antibiotics.
Measured conjunctival and anterior chamber bacterial contamination during cataract surgery; povidone-iodine markedly reduced conjunctival bacterial presence.
In patients with tobacco-associated oral lesions, chemiluminescence plus toluidine blue detected dysplasia with higher sensitivity than chemiluminescence plus Lugol's iodine.
In patients with tobacco-associated oral lesions, chemiluminescence plus toluidine blue detected dysplasia with higher sensitivity than chemiluminescence plus Lugol's iodine.
Randomized study showed both 5- and 10-minute povidone-iodine scrubs greatly reduced skin CFUs compared to painting alone, with no significant difference between 5 and 10 minutes.
Both povidone-iodine with isopropyl alcohol and chlorhexidine gluconate with isopropyl alcohol significantly reduced bacterial counts before forefoot surgery with no difference between methods.
Both povidone-iodine with isopropyl alcohol and chlorhexidine gluconate with isopropyl alcohol significantly reduced bacterial counts before forefoot surgery with no difference between methods.
A specifically manufactured 5% povidone-iodine nasal antiseptic (SNA) decreased nasal S. aureus carriage at 4 hours more than off-the-shelf 10% PI or saline, but differences were not sustained at 24 hours.
A specifically manufactured 5% povidone-iodine nasal antiseptic (SNA) decreased nasal S. aureus carriage at 4 hours more than off-the-shelf 10% PI or saline, but differences were not sustained at 24 hours.
Warming povidone-iodine before skin disinfection reduced preparation pain and shortened procedure time and needle attempts during PICC insertion in preterm infants compared with room-temperature PI.
Warming povidone-iodine before skin disinfection reduced preparation pain and shortened procedure time and needle attempts during PICC insertion in preterm infants compared with room-temperature PI.
Warming povidone-iodine before skin disinfection reduced preparation pain and shortened procedure time and needle attempts during PICC insertion in preterm infants compared with room-temperature PI.
Applying povidone-iodine to skin before wound closure removed surface contamination but did not demonstrably reduce wound infection or SSI rates in this randomized surgical sample.
Applying povidone-iodine to skin before wound closure removed surface contamination but did not demonstrably reduce wound infection or SSI rates in this randomized surgical sample.
Compared a new topical dressing to Alvogyl (which contains iodoform); new dressing gave faster short-term pain relief (30–60 min) but Alvogyl provided better pain control at 24–72 hours; no complications.
Compared a new topical dressing to Alvogyl (which contains iodoform); new dressing gave faster short-term pain relief (30–60 min) but Alvogyl provided better pain control at 24–72 hours; no complications.
Povidone-iodine suppositories and lactobacilli both improved BV; povidone-iodine reduced pathogenic bacteria more and showed significant benefit in acute BV at day 15.
Povidone-iodine suppositories and lactobacilli both improved BV; povidone-iodine reduced pathogenic bacteria more and showed significant benefit in acute BV at day 15.
Povidone-iodine suppositories and lactobacilli both improved BV; povidone-iodine reduced pathogenic bacteria more and showed significant benefit in acute BV at day 15.
In neonates, 2.5% povidone-iodine and 1% chloramphenicol both significantly reduced conjunctival bacterial colonies with no difference between them and no adverse effects.
In neonates, 2.5% povidone-iodine and 1% chloramphenicol both significantly reduced conjunctival bacterial colonies with no difference between them and no adverse effects.
DuraPrep plus drape was equivalent to povidone-iodine scrub/paint plus drape for wound contamination prevention, with less drape lift and lower cost for DuraPrep.
DuraPrep plus drape was equivalent to povidone-iodine scrub/paint plus drape for wound contamination prevention, with less drape lift and lower cost for DuraPrep.
Across >28,000 intravitreal injections, povidone-iodine use was associated with very low endophthalmitis rates; lack of povidone-iodine was associated with infections in the very small group not treated with it.
Across >28,000 intravitreal injections, povidone-iodine use was associated with very low endophthalmitis rates; lack of povidone-iodine was associated with infections in the very small group not treated with it.
In ED patients with simple traumatic wounds, cleansing skin with povidone-iodine did not reduce subsequent wound infection rates compared with control.
Low-dose iodine intake in endemic-goitre patients markedly increased urinary iodine and induced autoimmune thyroid changes in a subset (antibody rise, lymphocytic infiltration) with some developing hypo- or hyperthyroidism that mostly remitted after withdrawal.
Povidone-iodine 1.25% performed similarly to commonly available topical antibiotics for treating bacterial keratitis.
Povidone-iodine 1.25% performed similarly to commonly available topical antibiotics for treating bacterial keratitis.
Both PVP‑I 0.1% and boric acid 0.5% plus SRP improved periodontitis; boric acid produced greater reductions in gum inflammation and bleeding.
Randomized trial (n=36) comparing single-visit full-mouth ultrasonic debridement (one arm used povidone iodine) versus quadrant-wise therapy for chronic periodontitis; clinical and microbiological outcomes assessed up to 6 months.
Both PVP‑I 0.1% and boric acid 0.5% plus SRP improved periodontitis; boric acid produced greater reductions in gum inflammation and bleeding.
An optimized bolus-tracking threshold for DECT allowed maintenance of vascular image quality with about half the usual iodine contrast dose.
An optimized bolus-tracking threshold for DECT allowed maintenance of vascular image quality with about half the usual iodine contrast dose.
Preoperative vaginal douching with 1% povidone-iodine reduced postoperative infectious morbidity after total abdominal hysterectomy compared with no douching.
Iodine dosing based on lean body weight achieved equivalent aortic and hepatic CT enhancement while reducing iodine exposure in patients with normal/high BMI.
Iodine dosing based on lean body weight achieved equivalent aortic and hepatic CT enhancement while reducing iodine exposure in patients with normal/high BMI.
8-week randomized double-blind trial of boiled (iodine-reduced) kelp tablets in overweight Japanese adults: reduced body fat in men and lowered LDL in some subgroups; no thyroid hormone changes.
8-week randomized double-blind trial of boiled (iodine-reduced) kelp tablets in overweight Japanese adults: reduced body fat in men and lowered LDL in some subgroups; no thyroid hormone changes.
8-week randomized double-blind trial of boiled (iodine-reduced) kelp tablets in overweight Japanese adults: reduced body fat in men and lowered LDL in some subgroups; no thyroid hormone changes.
Randomized trial at cesarean delivery: povidone-iodine had higher incision-site bacterial culture positivity at 18 hours compared with chlorhexidine.
Adults undergoing intraocular surgery: povidone-iodine 5% effectively reduced conjunctival bacterial colonization; adding topical moxifloxacin provided no additional reduction.
In 28 patients, a 10 ml flush of 5% povidone-iodine reduced conjunctival bacterial organisms more than 2–3 drops (50% vs 18.7% reduction in broth media), though P=0.07.
Applying periocular 10% and conjunctival 5% povidone-iodine the day before and one hour before cataract surgery greatly reduced positive conjunctival cultures.
In neonates requiring central venous catheters, skin disinfection with 10% povidone-iodine was as effective as a chlorhexidine-impregnated dressing for preventing bloodstream infections, but had higher catheter-tip colonization and no contact dermatitis.
Alcohol-based chlorhexidine (0.5% and 1.0%) reduced catheter-tip colonization compared with 10% aqueous povidone-iodine; no significant difference in bloodstream infection rates.
Study comparing skin antisepsis methods for central venous catheter insertion: chlorhexidine-based prep reduced catheter colonization and catheter-related bloodstream infections compared with povidone-iodine.
Using 2% chlorhexidine in alcohol for skin disinfection was associated with a lower risk of catheter-related infection compared with alcoholic povidone-iodine in ICU patients.
Chlorhexidine-based skin antisepsis halved catheter colonization rates compared with alcohol-based povidone-iodine and showed a trend toward fewer bloodstream infections.
Aqueous povidone-iodine had higher catheter colonization (24.7%) than chlorhexidine solutions (~14–16%); bacteremia rates were similar across groups.
In this small neonatal pilot RCT, catheter colonization rates were similar between povidone-iodine and chlorhexidine groups; no dermatitis observed at chlorhexidine sites and chlorhexidine was detectable in some infants' blood.
Study comparing skin antisepsis methods for central venous catheter insertion: chlorhexidine-based prep reduced catheter colonization and catheter-related bloodstream infections compared with povidone-iodine.
Randomized trial in hospitalized men comparing povidone-iodine and octenidine for urethral antisepsis: similar antimicrobial efficacy but better local tolerability with povidone-iodine.
Randomized trial in hospitalized men comparing povidone-iodine and octenidine for urethral antisepsis: similar antimicrobial efficacy but better local tolerability with povidone-iodine.
Adding a 3-minute dilute povidone-iodine soak/scrub to standard alcohol+chlorhexidine skin prep did not reduce bacterial growth from the hallux nailfold.
In 24 neonates with major omphalocoele, topical povidone-iodine and Acacia paste had similar clinical outcomes; no thyroid test changes were observed with povidone-iodine.
In 30 children after full mouth rehab, periodic topical 10% povidone-iodine reduced Streptococcus mutans levels and was associated with fewer caries relapses over 12 months.
In 30 children after full mouth rehab, periodic topical 10% povidone-iodine reduced Streptococcus mutans levels and was associated with fewer caries relapses over 12 months.
In patients undergoing regional anesthesia, alcohol-based chlorhexidine produced fewer positive skin cultures after antisepsis than povidone-iodine (10% vs 35%).
In 26 patients undergoing tooth extraction, povidone-iodine gingival irrigation significantly reduced post-extraction bacteremia compared with placebo.
In 26 patients undergoing tooth extraction, povidone-iodine gingival irrigation significantly reduced post-extraction bacteremia compared with placebo.
Multicenter randomized double-blind trial: oral povidone-iodine vs placebo in high-risk ventilated patients showed no reduction in ventilator-associated pneumonia and a possible increase in ARDS.
Multicenter randomized double-blind trial: oral povidone-iodine vs placebo in high-risk ventilated patients showed no reduction in ventilator-associated pneumonia and a possible increase in ARDS.
Multicenter randomized double-blind trial: oral povidone-iodine vs placebo in high-risk ventilated patients showed no reduction in ventilator-associated pneumonia and a possible increase in ARDS.
Randomized trial in metastatic breast cancer patients found povidone-iodine pleurodesis provided similar symptom relief and recurrence rates to talc but shorter hospital stay.
Randomized trial in metastatic breast cancer patients found povidone-iodine pleurodesis provided similar symptom relief and recurrence rates to talc but shorter hospital stay.
Randomized trial in metastatic breast cancer patients found povidone-iodine pleurodesis provided similar symptom relief and recurrence rates to talc but shorter hospital stay.
Randomized clinical trial in 65 adults found applying povidone-iodine at surgery end did not reduce suture colonization rates.
Randomized clinical trial in 65 adults found applying povidone-iodine at surgery end did not reduce suture colonization rates.
Randomized clinical trial in 65 adults found applying povidone-iodine at surgery end did not reduce suture colonization rates.
Large multicentre RCT in LMICs comparing 2% alcoholic chlorhexidine versus 10% povidone‑iodine (and triclosan vs non‑coated sutures): no evidence that povidone‑iodine was inferior or superior to chlorhexidine for preventing surgical site infection.
Randomized trial in 220 gynecologic surgery patients found warming povidone-iodine reduced SSI compared with room-temperature povidone-iodine; overall PI and chlorhexidine had similar SSI rates.
Randomized trial in 220 gynecologic surgery patients found warming povidone-iodine reduced SSI compared with room-temperature povidone-iodine; overall PI and chlorhexidine had similar SSI rates.
Randomized trial in 220 gynecologic surgery patients found warming povidone-iodine reduced SSI compared with room-temperature povidone-iodine; overall PI and chlorhexidine had similar SSI rates.
Prospective randomized imaging study showed that virtual monochromatic low-energy images with ~50% reduced iodine contrast provided diagnostic aortoiliac CTA with higher intravascular attenuation and lower radiation dose-length product.
Prospective randomized imaging study showed that virtual monochromatic low-energy images with ~50% reduced iodine contrast provided diagnostic aortoiliac CTA with higher intravascular attenuation and lower radiation dose-length product.
Randomized high-risk COVID-19 outpatients to nasal irrigation with povidone-iodine vs alkalinization; few hospitalizations occurred and twice-daily irrigation was associated with better symptom resolution regardless of additive.
Randomized high-risk COVID-19 outpatients to nasal irrigation with povidone-iodine vs alkalinization; few hospitalizations occurred and twice-daily irrigation was associated with better symptom resolution regardless of additive.
Randomized high-risk COVID-19 outpatients to nasal irrigation with povidone-iodine vs alkalinization; few hospitalizations occurred and twice-daily irrigation was associated with better symptom resolution regardless of additive.
Povidone-iodine was used intraoperatively to reveal wound leaks during cataract surgery; leaks were sutured and re-operations decreased.
Povidone-iodine was used intraoperatively to reveal wound leaks during cataract surgery; leaks were sutured and re-operations decreased.
Compared topical antibiotics and 5% povidone-iodine for conjunctival flora; moxifloxacin was more effective and combination with povidone-iodine showed synergy.
Povidone-iodine/fluoride foam did not outperform fluoride foam alone for reducing cariogenic bacteria or caries indicators over one year.
Povidone-iodine/fluoride foam did not outperform fluoride foam alone for reducing cariogenic bacteria or caries indicators over one year.
Preoperative vaginal cleansing with 10% povidone-iodine reduced overall post-cesarean infectious morbidity, mainly by lowering endometritis rates.
Preoperative vaginal cleansing with 10% povidone-iodine reduced overall post-cesarean infectious morbidity, mainly by lowering endometritis rates.
Preoperative vaginal cleansing with 10% povidone-iodine reduced overall post-cesarean infectious morbidity, mainly by lowering endometritis rates.
In post-surgery CRS exacerbations, 1% povidone-iodine irrigations were well tolerated but had lower culture-negative rates than mupirocin.
Povidone-iodine and chlorhexidine procedures had comparable rapid in vivo bactericidal activity on skin flora up to 2 hours after application.
In post-surgery CRS exacerbations, 1% povidone-iodine irrigations were well tolerated but had lower culture-negative rates than mupirocin.
In post-surgery CRS exacerbations, 1% povidone-iodine irrigations were well tolerated but had lower culture-negative rates than mupirocin.
Povidone-iodine scrub-and-paint alone was less effective at sterilizing incision-site bacteria than protocols combining chlorhexidine.
Povidone-iodine scrub-and-paint alone was less effective at sterilizing incision-site bacteria than protocols combining chlorhexidine.
Contact lens wearers using a povidone-iodine disinfecting solution had no increase in ocular symptoms; some conjunctival signs decreased after lens wear.
Contact lens wearers using a povidone-iodine disinfecting solution had no increase in ocular symptoms; some conjunctival signs decreased after lens wear.
Contact lens wearers using a povidone-iodine disinfecting solution had no increase in ocular symptoms; some conjunctival signs decreased after lens wear.
Betadine (povidone-iodine) skin prep took longer and cost more than Chloraprep in a small prospective comparison.
Betadine (povidone-iodine) skin prep took longer and cost more than Chloraprep in a small prospective comparison.
In high-risk joint arthroplasty patients, dilute povidone-iodine (alone or with vancomycin) did not change 3‑month infection or wound complication rates compared with control.
In high-risk joint arthroplasty patients, dilute povidone-iodine (alone or with vancomycin) did not change 3‑month infection or wound complication rates compared with control.
In high-risk joint arthroplasty patients, dilute povidone-iodine (alone or with vancomycin) did not change 3‑month infection or wound complication rates compared with control.
Higher iodine concentration combined with a higher iodine delivery rate produced the best CT pulmonary angiography image quality and fewer beam-hardening artifacts.
Higher iodine concentration combined with a higher iodine delivery rate produced the best CT pulmonary angiography image quality and fewer beam-hardening artifacts.
Patients undergoing CABG had sternotomy wounds irrigated with either Dermacyn or povidone-iodine; Dermacyn group had fewer infections.
Compared fixed vs weight-adjusted iodine contrast dosing for cardiac CT; weight-adjusted dosing produced more consistent vascular enhancement and better image quality.
Compared fixed vs weight-adjusted iodine contrast dosing for cardiac CT; weight-adjusted dosing produced more consistent vascular enhancement and better image quality.
Compared fixed vs weight-adjusted iodine contrast dosing for cardiac CT; weight-adjusted dosing produced more consistent vascular enhancement and better image quality.
Term and preterm infants randomized to povidone-iodine or chlorhexidine-alcohol showed similar sepsis rates, but povidone-iodine was associated with higher neonatal TSH.
Term and preterm infants randomized to povidone-iodine or chlorhexidine-alcohol showed similar sepsis rates, but povidone-iodine was associated with higher neonatal TSH.
Preoperative conjunctival irrigation with povidone-iodine reduced bacterial load; 10% concentration was more effective than 1% or 5%.
In adults undergoing clean-contaminated surgery, skin preparation with povidone-iodine had a higher rate of surgical-site infection than chlorhexidine-alcohol.
Subgroup analysis comparing antiseptic agents in implant surgery showed similar surgical site infection rates between povidone-iodine regimens and chlorhexidine-alcohol.
Combination povidone-iodine+dexamethasone improved vision scores, reduced infiltrate severity, and lowered recurrence compared with either agent alone.
Combination povidone-iodine+dexamethasone improved vision scores, reduced infiltrate severity, and lowered recurrence compared with either agent alone.
Combination povidone-iodine+dexamethasone improved vision scores, reduced infiltrate severity, and lowered recurrence compared with either agent alone.
In ICU catheter dressings, povidone-iodine dressings had higher catheter-related bloodstream infection and exit-site infection signs than hypochlorous-acid dressings.
In ICU catheter dressings, povidone-iodine dressings had higher catheter-related bloodstream infection and exit-site infection signs than hypochlorous-acid dressings.
Irrigating the conjunctival sac with 1% povidone-iodine markedly reduced conjunctival bacterial load before cataract surgery.
Randomized comparison of three eye‑washing methods before cataract surgery; a single drop of 5% povidone‑iodine reduced conjunctival bacteria immediately after washing.
Irrigating the conjunctival sac with 1% povidone-iodine markedly reduced conjunctival bacterial load before cataract surgery.
Irrigating the conjunctival sac with 1% povidone-iodine markedly reduced conjunctival bacterial load before cataract surgery.
Postoperative topical povidone-iodine ointment did not significantly reduce the need for revision surgery compared with control; lipid Amphotericin-B gel was effective.
Use of iodinated contrast (iohexol) was associated with increases in creatinine and a measurable rate of contrast-induced nephropathy compared with gadodiamide mixed with a small amount of iohexol.
Reapplying an iodophor-containing surgical site preparation (including povidone-iodine components) before draping significantly lowered superficial surgical site infection after joint arthroplasty.
Reapplying an iodophor-containing surgical site preparation (including povidone-iodine components) before draping significantly lowered superficial surgical site infection after joint arthroplasty.
Exposure to high-osmolal iodinated contrast (ioxitalamate) was associated with substantial rates of contrast-induced AKI; adding NAC or sodium bicarbonate to saline hydration provided no clear additional protection versus saline alone.
Exposure to high-osmolal iodinated contrast (ioxitalamate) was associated with substantial rates of contrast-induced AKI; adding NAC or sodium bicarbonate to saline hydration provided no clear additional protection versus saline alone.
Exposure to high-osmolal iodinated contrast (ioxitalamate) was associated with substantial rates of contrast-induced AKI; adding NAC or sodium bicarbonate to saline hydration provided no clear additional protection versus saline alone.
Using 10% povidone-iodine as the cooling liquid during ultrasonic non-surgical periodontal therapy gave limited additional clinical benefit but reduced certain microbiological markers and the proportion of deep pockets at 6 months.
Using 10% povidone-iodine as the cooling liquid during ultrasonic non-surgical periodontal therapy gave limited additional clinical benefit but reduced certain microbiological markers and the proportion of deep pockets at 6 months.
Using 10% povidone-iodine as the cooling liquid during ultrasonic non-surgical periodontal therapy gave limited additional clinical benefit but reduced certain microbiological markers and the proportion of deep pockets at 6 months.
Preoperative skin preparation with chlorhexidine reduced bacterial colonization and postoperative wound infections more than povidone-iodine.
Preoperative skin preparation with chlorhexidine reduced bacterial colonization and postoperative wound infections more than povidone-iodine.
Compared lavender oil to povidone-iodine for episiotomy care; povidone-iodine was associated with more redness while pain and complication rates were similar.
Using povidone-iodine as an irrigant after third-molar removal was associated with more pain, alveolar osteitis, swelling, and trismus compared with chlorhexidine.
Low-concentration povidone-iodine irrigation during third molar extraction reduced postoperative swelling and trismus but did not significantly change pain; higher patient satisfaction reported for the PVI-treated side.
Compared lavender oil to povidone-iodine for episiotomy care; povidone-iodine was associated with more redness while pain and complication rates were similar.
Compared lavender oil to povidone-iodine for episiotomy care; povidone-iodine was associated with more redness while pain and complication rates were similar.
Sterile saline and 1% povidone-iodine had similar antimicrobial effectiveness and surgical success for VVF repair, but povidone-iodine was associated with more irritation symptoms.
Sterile saline and 1% povidone-iodine had similar antimicrobial effectiveness and surgical success for VVF repair, but povidone-iodine was associated with more irritation symptoms.
Sterile saline and 1% povidone-iodine had similar antimicrobial effectiveness and surgical success for VVF repair, but povidone-iodine was associated with more irritation symptoms.
Compared shower+saline skin prep vs traditional scrub with povidone-iodine/chlorhexidine in outpatient plastic surgery; no wound infections occurred in either group.
Randomized trial comparing CO2 vs iodinated contrast for ilio-femoral angioplasty: iodinated contrast gave similar technical success and no worsening of renal function, with higher contrast costs and uniformly good image ratings.
In a small randomized study, CO2 contrast produced comparable angiographic images and clinical outcomes to iodine contrast without worsening kidney function and reduced contrast costs.
Randomized trial comparing CO2 vs iodinated contrast for ilio-femoral angioplasty: iodinated contrast gave similar technical success and no worsening of renal function, with higher contrast costs and uniformly good image ratings.
Randomized trial comparing CO2 vs iodinated contrast for ilio-femoral angioplasty: iodinated contrast gave similar technical success and no worsening of renal function, with higher contrast costs and uniformly good image ratings.
Double-blind RCT in toddlers comparing single topical 10% PVP-I vs 0.2% CHX gel vs water: PVP-I reduced plaque at Day 3 but was not superior to CHX or placebo by Day 7 after single application.
Double-blind RCT in toddlers comparing single topical 10% PVP-I vs 0.2% CHX gel vs water: PVP-I reduced plaque at Day 3 but was not superior to CHX or placebo by Day 7 after single application.
Prospective randomized trial in children prior to catheterization comparing sterile water vs 10% povidone-iodine periurethral cleansing: no difference in positive urine cultures.
Randomized study of 5% povidone-iodine conjunctival irrigation for varying durations before cataract surgery: 2.0 min and 3.5 min reduced conjunctival bacterial culture positivity more than 30 s or 1.0 min; 2.0 min balanced efficacy and lower short-term corneal epithelial injury compared with 3.5 min.
Randomized study of 5% povidone-iodine conjunctival irrigation for varying durations before cataract surgery: 2.0 min and 3.5 min reduced conjunctival bacterial culture positivity more than 30 s or 1.0 min; 2.0 min balanced efficacy and lower short-term corneal epithelial injury compared with 3.5 min.
A single intranasal application of a povidone-iodine solution sharply reduced nasal bacterial load without impairing mucociliary function and produced modest changes in microbial composition at 24 h.
A single intranasal application of a povidone-iodine solution sharply reduced nasal bacterial load without impairing mucociliary function and produced modest changes in microbial composition at 24 h.
A single intranasal application of a povidone-iodine solution sharply reduced nasal bacterial load without impairing mucociliary function and produced modest changes in microbial composition at 24 h.
Combination PVP-I 1% plus dexamethasone accelerated symptom resolution and viral clearance in adenoviral keratoconjunctivitis versus controls and reduced later complications.
Combination PVP-I 1% plus dexamethasone accelerated symptom resolution and viral clearance in adenoviral keratoconjunctivitis versus controls and reduced later complications.
Combination PVP-I 1% plus dexamethasone accelerated symptom resolution and viral clearance in adenoviral keratoconjunctivitis versus controls and reduced later complications.
Both subgingival irrigation with 1% PVP-I and 0.75% boric acid reduced periodontal pathogens and improved clinical parameters, but boric acid produced greater pocket depth and attachment gains over 12 months.
Both subgingival irrigation with 1% PVP-I and 0.75% boric acid reduced periodontal pathogens and improved clinical parameters, but boric acid produced greater pocket depth and attachment gains over 12 months.
Both subgingival irrigation with 1% PVP-I and 0.75% boric acid reduced periodontal pathogens and improved clinical parameters, but boric acid produced greater pocket depth and attachment gains over 12 months.
Povidone-iodine skin prep left a higher rate of positive post-preparation cultures than chlorhexidine-alcohol in genitourinary prosthetic surgery patients.
Povidone-iodine skin prep left a higher rate of positive post-preparation cultures than chlorhexidine-alcohol in genitourinary prosthetic surgery patients.
Oral rinsing with povidone-iodine during radiochemotherapy markedly reduced incidence, severity and duration of oral mucositis compared with control rinsing.
Oral rinsing with povidone-iodine during radiochemotherapy markedly reduced incidence, severity and duration of oral mucositis compared with control rinsing.
Oral rinsing with povidone-iodine during radiochemotherapy markedly reduced incidence, severity and duration of oral mucositis compared with control rinsing.
Topical liposome PVP-I hydrogel accelerated healing of partial-thickness burns and yielded better cosmetic outcomes versus silver-sulfadiazine cream.
Topical liposome PVP-I hydrogel accelerated healing of partial-thickness burns and yielded better cosmetic outcomes versus silver-sulfadiazine cream.
Adding extra proparacaine drops did not change patient experience and had higher conjunctival culture positivity than povidone-iodine antisepsis.
Topical ofloxacin reduced conjunctival bacteria and adding preoperative 5% povidone-iodine further reduced conjunctival flora to very low levels; anterior chamber contamination was rare.
Adding extra proparacaine drops did not change patient experience and had higher conjunctival culture positivity than povidone-iodine antisepsis.
Iodixanol-320 at 5.0 mL/s produced better stent image evaluability and fewer artifacts than the other contrast protocols.
Iodixanol-320 at 5.0 mL/s produced better stent image evaluability and fewer artifacts than the other contrast protocols.
Preoperative vaginal disinfection with 10% povidone-iodine did not significantly change endometritis rates but lowered postoperative inflammatory markers.
Preoperative vaginal disinfection with 10% povidone-iodine did not significantly change endometritis rates but lowered postoperative inflammatory markers.
Povidone-iodine meatal antisepsis did not match systemic antibiotic prophylaxis in preventing intraoperative bacteraemia or meatal bacterial growth, and none reduced catheter-related bacteriuria.
Povidone-iodine meatal antisepsis did not match systemic antibiotic prophylaxis in preventing intraoperative bacteraemia or meatal bacterial growth, and none reduced catheter-related bacteriuria.
A povidone-iodine mouth rinse produced a short-term reduction in salivary SARS-CoV-2 viral load as measured by increased RT-PCR Ct values.
A povidone-iodine mouth rinse produced a short-term reduction in salivary SARS-CoV-2 viral load as measured by increased RT-PCR Ct values.
Intraoperative wound irrigation with dilute povidone-iodine markedly reduced surgical site infection rates compared with saline plus gentamicin.
Intraoperative wound irrigation with dilute povidone-iodine markedly reduced surgical site infection rates compared with saline plus gentamicin.
In dirty surgical wounds, packing with oxidized regenerated cellulose reduced bacterial contamination more often than gauze soaked in iodine; no clinical surgical-site infections occurred in either group.
In patients with severely impaired renal function, iodinated contrast (iohexol) produced a mean GFR decline at 48 h and a high incidence of acute renal failure, with no benefit over gadolinium.
In patients with severely impaired renal function, iodinated contrast (iohexol) produced a mean GFR decline at 48 h and a high incidence of acute renal failure, with no benefit over gadolinium.
Using lean body weight to calculate iodine dose for CT provided more consistent hepatic enhancement across patients and reduced variability compared with dosing by total body weight or estimated blood volume.
Using lean body weight to calculate iodine dose for CT provided more consistent hepatic enhancement across patients and reduced variability compared with dosing by total body weight or estimated blood volume.
In adults undergoing clean-contaminated surgery, skin preparation with povidone-iodine had a higher rate of surgical-site infection than chlorhexidine-alcohol.
In 28 healthy volunteers, adding alcohol to povidone-iodine increased reduction of bacterial load on the foot, but nailfolds remained contaminated with all methods.
In elective foot and ankle surgery patients, povidone-iodine skin prep resulted in more positive cultures than chlorhexidine with alcohol.
Giving a second povidone-iodine eye drop within the first day did not reduce neonatal conjunctivitis compared with a single drop; double dosing had slightly more eyelid swelling.
A preoperative vaginal wash with povidone-iodine before C-section reduced postoperative infectious events compared with no wash, but the difference was not statistically significant.
A 1-minute povidone-iodine scrub followed by alcohol foam produced similar or fewer skin bacterial colonies than a 5-minute povidone-iodine scrub.
Preoperative PVP-iodine was superior to topical antibiotics for eye prep, reducing bacterial counts substantially and eliminating fungi.
Preoperative PVP-iodine was superior to topical antibiotics for eye prep, reducing bacterial counts substantially and eliminating fungi.
Using povidone-iodine as an irrigant after third-molar removal was associated with more pain, alveolar osteitis, swelling, and trismus compared with chlorhexidine.
Chlorhexidine-based skin antisepsis halved catheter colonization rates compared with alcohol-based povidone-iodine and showed a trend toward fewer bloodstream infections.
Randomized trial comparing 2% chlorhexidine-alcohol versus 10% povidone-iodine for pin-site care; no difference in pin-site infection rates, and infection risk rose with longer fixator duration.
Randomized trial comparing 2% chlorhexidine-alcohol versus 10% povidone-iodine for pin-site care; no difference in pin-site infection rates, and infection risk rose with longer fixator duration.
Randomized study of preoperative topical ciprofloxacin with routine 10% povidone-iodine surgical field preparation; povidone-iodine substantially reduced conjunctival culture positivity immediately after application.
Randomized study of preoperative topical ciprofloxacin with routine 10% povidone-iodine surgical field preparation; povidone-iodine substantially reduced conjunctival culture positivity immediately after application.
Randomized controlled trial comparing daily topical 10% PVP-I plus saline dressing versus saline alone for Ilizarov wire/pin sites; no reduction in superficial infection incidence with PVP-I.
Randomized controlled trial comparing daily topical 10% PVP-I plus saline dressing versus saline alone for Ilizarov wire/pin sites; no reduction in superficial infection incidence with PVP-I.
Randomized trial of full-mouth ultrasonic debridement using 10% povidone-iodine versus saline as irrigant in generalized aggressive periodontitis; no additional clinical, immunological or broad microbiological benefit, though Aa levels in deep pockets decreased.
Randomized trial of full-mouth ultrasonic debridement using 10% povidone-iodine versus saline as irrigant in generalized aggressive periodontitis; no additional clinical, immunological or broad microbiological benefit, though Aa levels in deep pockets decreased.
Double-blind randomized study of four mouthwashes including povidone-iodine used for two weeks in chronic gingivitis; povidone-iodine reduced plaque/gingival indices and pro-inflammatory cytokines IL-2 and IFN-γ significantly.
Double-blind randomized study of four mouthwashes including povidone-iodine used for two weeks in chronic gingivitis; povidone-iodine reduced plaque/gingival indices and pro-inflammatory cytokines IL-2 and IFN-γ significantly.
Double-blind randomized study of four mouthwashes including povidone-iodine used for two weeks in chronic gingivitis; povidone-iodine reduced plaque/gingival indices and pro-inflammatory cytokines IL-2 and IFN-γ significantly.
Pilot comparative study of DSIG (contains iodine glycerin) cream versus topical mouth rinse for chemotherapy-induced oral mucositis; DSIG produced lower OAG severity scores and faster complete regression.
Pilot comparative study of DSIG (contains iodine glycerin) cream versus topical mouth rinse for chemotherapy-induced oral mucositis; DSIG produced lower OAG severity scores and faster complete regression.
Pilot comparative study of DSIG (contains iodine glycerin) cream versus topical mouth rinse for chemotherapy-induced oral mucositis; DSIG produced lower OAG severity scores and faster complete regression.
Randomized trial comparing daily 225 μg iodine capsules versus adequately iodized salt for 26 weeks in lactating women; maternal TSH and goiter prevalence decreased with supplementation and infants in the iodized salt arm showed higher novelty preference (memory) scores.
Randomized trial comparing daily 225 μg iodine capsules versus adequately iodized salt for 26 weeks in lactating women; maternal TSH and goiter prevalence decreased with supplementation and infants in the iodized salt arm showed higher novelty preference (memory) scores.
Randomized trial comparing daily 225 μg iodine capsules versus adequately iodized salt for 26 weeks in lactating women; maternal TSH and goiter prevalence decreased with supplementation and infants in the iodized salt arm showed higher novelty preference (memory) scores.
Adding dilute povidone-iodine (0.02%) to sterile water splash basins eliminated intraoperative basin contamination during joint arthroplasty.
Partially replacing animal proteins with plant proteins for 12 weeks lowered iodine intake and urinary iodine excretion in healthy adults.
Using 5% povidone-iodine drops at the end of cataract surgery caused less immediate postoperative pain than subconjunctival injection and produced similar inflammation and visual outcomes.
Using 5% povidone-iodine drops at the end of cataract surgery caused less immediate postoperative pain than subconjunctival injection and produced similar inflammation and visual outcomes.
Coating PEG tubes with 10% povidone-iodine did not reduce infections but reduced short-term inflammatory markers after the procedure.
Coating PEG tubes with 10% povidone-iodine did not reduce infections but reduced short-term inflammatory markers after the procedure.
Coating PEG tubes with 10% povidone-iodine did not reduce infections but reduced short-term inflammatory markers after the procedure.
Intraoperative irrigation with 10% aqueous povidone-iodine did not reduce incisional surgical-site infections compared with saline.
Rinsing with povidone-iodine reduced how often and how bad mouth sores were during cancer radiochemotherapy.
In head-and-neck cancer patients receiving radiochemotherapy, adding povidone-iodine oral rinses reduced how often, how severe, and how long oral mucositis occurred compared with sterile water.
In head-and-neck cancer patients receiving radiochemotherapy, adding povidone-iodine oral rinses reduced how often, how severe, and how long oral mucositis occurred compared with sterile water.
Rinsing with povidone-iodine reduced how often and how bad mouth sores were during cancer radiochemotherapy.
Rinsing with povidone-iodine reduced how often and how bad mouth sores were during cancer radiochemotherapy.
PVP-I plus alcohol produced rapid bacterial reductions but its antimicrobial persistence was shorter (up to 96 h) than chlorhexidine+alcohol (up to 7 days) in healthy volunteers.
PVP-I plus alcohol produced rapid bacterial reductions but its antimicrobial persistence was shorter (up to 96 h) than chlorhexidine+alcohol (up to 7 days) in healthy volunteers.
Alcoholic 5% povidone-iodine significantly reduced skin bacterial counts with all application modes; back-and-forth friction gave slightly better reduction than concentric circles.
Alcoholic 5% povidone-iodine significantly reduced skin bacterial counts with all application modes; back-and-forth friction gave slightly better reduction than concentric circles.
Sixty volunteers compared hand sanitizers (including povidone-iodine); alcohol-based products worked well and rings only worsened outcomes with povidone-iodine.
Sixty volunteers compared hand sanitizers (including povidone-iodine); alcohol-based products worked well and rings only worsened outcomes with povidone-iodine.
Twenty-four patients had root canals treated and filled with iodine-potassium-iodide dressing; microbial samples showed partial reduction of microbes with IKI but no difference between preparation methods.
Twenty-four patients had root canals treated and filled with iodine-potassium-iodide dressing; microbial samples showed partial reduction of microbes with IKI but no difference between preparation methods.
Forty patients underwent CT angiography with a low-iodine contrast protocol; image quality remained diagnostic while iodine dose and radiation dose were reduced.
Low tube voltage + low-concentration contrast and iterative reconstruction produced similar image quality with lower radiation and iodine dose.
Randomized study in obese patients comparing conventional CT protocol vs a 'double-low' protocol (lower kVp and lower-concentration iodine) plus AIIR reconstruction, assessing image quality, radiation dose, and iodine intake.
Using spectral CT with a lower‑concentration iodinated contrast reduced total iodine dose by ~28% while achieving equal or better vascular image quality than conventional CTA.
Forty patients underwent CT angiography with a low-iodine contrast protocol; image quality remained diagnostic while iodine dose and radiation dose were reduced.
Fifty patients randomized to nasal disinfection with benzalkonium chloride or povidone-iodine showed that PVI gave a stronger immediate reduction in nasal bacteria but BZK provided more sustained suppression after intubation.
Fifty patients randomized to nasal disinfection with benzalkonium chloride or povidone-iodine showed that PVI gave a stronger immediate reduction in nasal bacteria but BZK provided more sustained suppression after intubation.
Fifty patients randomized to nasal disinfection with benzalkonium chloride or povidone-iodine showed that PVI gave a stronger immediate reduction in nasal bacteria but BZK provided more sustained suppression after intubation.
Sixty women were randomized to periurethral cleansing with water or povidone-iodine before catheter insertion; no difference was found in bacteriuria or UTI rates.
Rectal cleansing with 10% povidone-iodine plus formalin dipping of the needle tip reduced infectious complications after transrectal prostate biopsy.
Sixty women were randomized to periurethral cleansing with water or povidone-iodine before catheter insertion; no difference was found in bacteriuria or UTI rates.
Iodopovidone and doxycycline had similar pleurodesis success rates; iodopovidone caused higher chest pain scores but similar complication rates.
Randomized trial in patients with malignant pleural effusion found povidone-iodine pleurodesis had similar success and complication rates to talc.
Randomized trial in patients with malignant pleural effusion found povidone-iodine pleurodesis had similar success and complication rates to talc.
Randomized trial in patients with malignant pleural effusion found povidone-iodine pleurodesis had similar success and complication rates to talc.
Randomized trial comparing turmeric gargle to povidone-iodine gargle during radiotherapy found povidone-iodine was less effective than turmeric at delaying and reducing mucositis.
Randomized trial comparing turmeric gargle to povidone-iodine gargle during radiotherapy found povidone-iodine was less effective than turmeric at delaying and reducing mucositis.
Prospective randomized trial found povidone-iodine skin prep was associated with more surgical-site infections and wound-healing disorders than chlorhexidine in lower limb trauma surgery.
Irrigating the fornices with 5% povidone-iodine before eye surgery reduced positive conjunctival bacterial cultures compared with two drops.
Chlorhexidine reduced early intraoperative vaginal bacterial contamination more than povidone-iodine; differences later during surgery were not significant.
Using chlorhexidine/propanol followed by povidone-iodine for skin disinfection before CVC insertion produced much lower catheter tip bacterial colonization than either agent alone.
Topical dexamethasone 0.1% with povidone-iodine 0.4% shortened conjunctivitis duration by about 2.4 days but caused more stinging than artificial tears.
Topical dexamethasone 0.1% with povidone-iodine 0.4% shortened conjunctivitis duration by about 2.4 days but caused more stinging than artificial tears.
When total iodine delivery rate and dose were kept constant per body surface area, CT and PET quantitative and visual results did not differ between contrast media with 300 mg/ml and 370 mg/ml iodine.
Gargling with povidone-iodine did not change SARS-CoV-2 Ct values overall, though more patients converted from positive to negative after antiseptic gargle in some analyses.
Gargling with povidone-iodine did not change SARS-CoV-2 Ct values overall, though more patients converted from positive to negative after antiseptic gargle in some analyses.
Cadexomer iodine paste healed venous leg ulcers faster and reduced ulcer size more than comparators.
Cadexomer iodine paste healed venous leg ulcers faster and reduced ulcer size more than comparators.
Cadexomer iodine paste healed venous leg ulcers faster and reduced ulcer size more than comparators.
Povidone-iodine caused more immediate pain and corneal surface damage than aqueous chlorhexidine, with no difference in microbial culture rates.
Povidone-iodine caused more immediate pain and corneal surface damage than aqueous chlorhexidine, with no difference in microbial culture rates.
Povidone-iodine caused more immediate pain and corneal surface damage than aqueous chlorhexidine, with no difference in microbial culture rates.
Higher iodine concentration (400 mg/mL) produced greater liver and vascular enhancement and better image quality than 350 mg/mL in chronic liver disease patients.
Higher iodine concentration (400 mg/mL) produced greater liver and vascular enhancement and better image quality than 350 mg/mL in chronic liver disease patients.
Higher iodine concentration (400 mg/mL) produced greater liver and vascular enhancement and better image quality than 350 mg/mL in chronic liver disease patients.
Preoperative oral antiseptic washes reduced intra-oral bacterial counts; povidone-iodine worked well for procedures up to 1 hour but chlorhexidine and cetrimide had longer effects.
Preoperative oral antiseptic washes reduced intra-oral bacterial counts; povidone-iodine worked well for procedures up to 1 hour but chlorhexidine and cetrimide had longer effects.
Using Dynamic Coronary Roadmap guidance significantly reduced the volume of iodinated contrast and number of cineangiography runs during PCI.
Using Dynamic Coronary Roadmap guidance significantly reduced the volume of iodinated contrast and number of cineangiography runs during PCI.
Randomized trial (n=142) showed that adding PVI 10% plus levofloxacin 1 hour pre-op substantially reduced conjunctival culture positivity immediately before surgery.
Randomized trial (n=142) showed that adding PVI 10% plus levofloxacin 1 hour pre-op substantially reduced conjunctival culture positivity immediately before surgery.
Randomized trial (n=142) showed that adding PVI 10% plus levofloxacin 1 hour pre-op substantially reduced conjunctival culture positivity immediately before surgery.
Randomized trial (n=100) comparing rectal sterilization with 10% povidone-iodine versus control found a higher number of positive blood cultures in the PVI group in the reported results.
Randomized trial (n=126) testing dissolvable punctal plugs after intravitreal injection prep with PVI found no overall reduction in ocular surface symptoms, but benefit in subgroup with objective dry eye.
Randomized trial (n=126) testing dissolvable punctal plugs after intravitreal injection prep with PVI found no overall reduction in ocular surface symptoms, but benefit in subgroup with objective dry eye.
Large randomized study (n=516) comparing cord care agents found chlorhexidine reduced cord colonization but prolonged cord separation time; povidone-iodine did not show superior colonization reduction.
Large randomized study (n=516) comparing cord care agents found chlorhexidine reduced cord colonization but prolonged cord separation time; povidone-iodine did not show superior colonization reduction.
Large randomized study (n=516) comparing cord care agents found chlorhexidine reduced cord colonization but prolonged cord separation time; povidone-iodine did not show superior colonization reduction.
In head-and-neck cancer patients receiving radiochemotherapy, adding povidone-iodine oral rinses reduced how often, how severe, and how long oral mucositis occurred compared with sterile water.
Instilling three 5% povidone-iodine drops over ~28 minutes (PI plus) reduced conjunctival bacterial cultures more than a single drop, without detectable corneal toxicity.
Instilling three 5% povidone-iodine drops over ~28 minutes (PI plus) reduced conjunctival bacterial cultures more than a single drop, without detectable corneal toxicity.
Using 10% PVP-iodine rinsing before and during subgingival ultrasonic scaling substantially reduced the prevalence and magnitude of oral-derived bacteraemia compared with water.
Using 10% PVP-iodine rinsing before and during subgingival ultrasonic scaling substantially reduced the prevalence and magnitude of oral-derived bacteraemia compared with water.
Shortening injection time with higher-concentration iodine increased arterial (aortic) enhancement on liver CT while portal and hepatic enhancement were unchanged.
Shortening injection time with higher-concentration iodine increased arterial (aortic) enhancement on liver CT while portal and hepatic enhancement were unchanged.
Shortening injection time with higher-concentration iodine increased arterial (aortic) enhancement on liver CT while portal and hepatic enhancement were unchanged.
Adding vancomycin to irrigating fluid reduced positive intraocular cultures after cataract surgery; intracameral vancomycin has a half-life under 2 hours.
Adding vancomycin to irrigating fluid reduced positive intraocular cultures after cataract surgery; intracameral vancomycin has a half-life under 2 hours.
Nasal povidone-iodine around surgery produced similar overall deep SSI rates to mupirocin, but per-protocol analysis showed elimination of S. aureus deep SSIs in the povidone group.
Nasal povidone-iodine around surgery produced similar overall deep SSI rates to mupirocin, but per-protocol analysis showed elimination of S. aureus deep SSIs in the povidone group.
One-visit treatment including a 10-min 5% iodine-potassium-iodide dressing left residual microbes in 29% of teeth, similar to 36% after two-visit treatment.
One-visit treatment including a 10-min 5% iodine-potassium-iodide dressing left residual microbes in 29% of teeth, similar to 36% after two-visit treatment.
Povidone iodine 0.2% was as effective as 1% silver nitrate for renal pelvic sclerotherapy with similar recurrence and slightly higher immediate clearance and less flank pain.
Povidone iodine 0.2% was as effective as 1% silver nitrate for renal pelvic sclerotherapy with similar recurrence and slightly higher immediate clearance and less flank pain.
Povidone iodine 0.2% was as effective as 1% silver nitrate for renal pelvic sclerotherapy with similar recurrence and slightly higher immediate clearance and less flank pain.
Using povidone-iodine spray for CAPD exit care did not meaningfully reduce exit infections or peritonitis; it altered organism profile and caused rash in some patients.
Polyhexanide tended to reduce exit-site infections and peritonitis rates compared with povidone-iodine, but differences were not statistically significant.
Using povidone-iodine spray for CAPD exit care did not meaningfully reduce exit infections or peritonitis; it altered organism profile and caused rash in some patients.
Using povidone-iodine spray for CAPD exit care did not meaningfully reduce exit infections or peritonitis; it altered organism profile and caused rash in some patients.
Irrigating the gingival sulcus with povidone-iodine before dental treatment reduced post-treatment bacteremia compared with chlorhexidine or water.
Randomized study comparing three skin-prep solutions for shoulder surgery cultures; chlorhexidine performed best overall.
Randomized study comparing three skin-prep solutions for shoulder surgery cultures; chlorhexidine performed best overall.
Randomized comparison of two high-iodine contrast agents showing higher standardized attenuation for iopromide 370 but similar subjective image quality.
Randomized comparison of two high-iodine contrast agents showing higher standardized attenuation for iopromide 370 but similar subjective image quality.
Randomized trial showing lower wound inflammation signs and lower pain when combined alcohol-based antiseptic plus povidone-iodine was used versus povidone-iodine alone.
Randomized trial showing lower wound inflammation signs and lower pain when combined alcohol-based antiseptic plus povidone-iodine was used versus povidone-iodine alone.
Randomized trial showing lower wound inflammation signs and lower pain when combined alcohol-based antiseptic plus povidone-iodine was used versus povidone-iodine alone.
Randomized trial showing lower wound inflammation signs and lower pain when combined alcohol-based antiseptic plus povidone-iodine was used versus povidone-iodine alone.
Large randomized trial that found a non-statistically-significant reduction in infectious complications with povidone-iodine rectal cleansing before prostate biopsy.
Large randomized trial that found a non-statistically-significant reduction in infectious complications with povidone-iodine rectal cleansing before prostate biopsy.
Randomized double-blind study showing similar coronary and chamber enhancement using 300 mg I/ml vs 400 mg I/ml protocols with adjusted volumes/flows.
People with differentiated thyroid cancer ate less vegetables, fruit, saltwater fish and cottage cheese than controls; diets rich in those foods may be protective.
People with differentiated thyroid cancer ate less vegetables, fruit, saltwater fish and cottage cheese than controls; diets rich in those foods may be protective.
People with differentiated thyroid cancer ate less vegetables, fruit, saltwater fish and cottage cheese than controls; diets rich in those foods may be protective.
Applying 5% povidone-iodine to the eye markedly reduced conjunctival bacteria; at least 30 seconds exposure needed; lid speculum had no effect.
Applying 5% povidone-iodine to the eye markedly reduced conjunctival bacteria; at least 30 seconds exposure needed; lid speculum had no effect.
No difference found between 10% povidone-iodine and 0.5% chlorhexidine ethanol in catheter site or tip colonization for short-term epidural catheters.
Using FloShield resulted in fewer laparoscope removals than the reference water + povidone-iodine technique, with no difference in vision quality or cleaning time.
Using FloShield resulted in fewer laparoscope removals than the reference water + povidone-iodine technique, with no difference in vision quality or cleaning time.
Preoperative intraoral preparation with povidone-iodine significantly and sustainably reduced oral aerobic and anaerobic bacteria compared with saline or no preparation.
Polyhexanide tended to reduce exit-site infections and peritonitis rates compared with povidone-iodine, but differences were not statistically significant.
In this small randomized pilot, adding povidone-iodine dressing plus mupirocin did not clearly reduce exit-site infections compared to mupirocin alone; peritonitis occurred sooner in the dressing group.
Adding three drops of 10% povidone-iodine before cataract surgery further reduced conjunctival bacterial contamination compared with standard 1% irrigation alone.
Alginate mesh and polyvidone-iodine mesh produced similar stoma healing at 28 days, but the polyvidone-iodine group required more meshes.
Alginate mesh and polyvidone-iodine mesh produced similar stoma healing at 28 days, but the polyvidone-iodine group required more meshes.
Alginate mesh and polyvidone-iodine mesh produced similar stoma healing at 28 days, but the polyvidone-iodine group required more meshes.
Use of nonsterile ultrasound gel before antisepsis did not significantly affect biopsy-site bacterial contamination after povidone-iodine antisepsis.
Use of nonsterile ultrasound gel before antisepsis did not significantly affect biopsy-site bacterial contamination after povidone-iodine antisepsis.
Povidone-iodine 1.25% was as effective as topical antibiotic for bacterial conjunctivitis and showed marginally better early chlamydial cure, but was ineffective for viral conjunctivitis.
Povidone-iodine 1.25% was as effective as topical antibiotic for bacterial conjunctivitis and showed marginally better early chlamydial cure, but was ineffective for viral conjunctivitis.
No antiseptic solution (alcohol-based chlorhexidine, alcohol-based povidone-iodine, or water-based povidone-iodine) reduced surgical site infection rates compared with the others in gynecological laparoscopy.
No antiseptic solution (alcohol-based chlorhexidine, alcohol-based povidone-iodine, or water-based povidone-iodine) reduced surgical site infection rates compared with the others in gynecological laparoscopy.
Postoperative 0.1% povidone-iodine nasal irrigation provided no additional benefit over normal saline for sinonasal surgery recovery.
Postoperative 0.1% povidone-iodine nasal irrigation provided no additional benefit over normal saline for sinonasal surgery recovery.
Adding topical PVP-I to non-surgical periodontal therapy provided no additional benefit over control at 6 months.
Adding topical PVP-I to non-surgical periodontal therapy provided no additional benefit over control at 6 months.
Adding topical PVP-I to non-surgical periodontal therapy provided no additional benefit over control at 6 months.
Ocular safety (corneal punctate keratitis and conjunctival hyperemia) was similar between Amukine and 5% povidone-iodine.
Ocular safety (corneal punctate keratitis and conjunctival hyperemia) was similar between Amukine and 5% povidone-iodine.
Adding lithium to radioactive iodine therapy produced earlier and greater reductions in serum T4 compared with RAI alone.
Adding lithium to radioactive iodine therapy produced earlier and greater reductions in serum T4 compared with RAI alone.
Minocycline ointment produced greater improvement than the control treatment (10% iodine applied around teeth) in plaque index, probing depth, and sulcus bleeding index for early peri-implantitis.
Scaling and root planing combined with subgingival irrigation using a 10% iodised solution produced greater clinical improvements than other techniques.
Scaling and root planing combined with subgingival irrigation using a 10% iodised solution produced greater clinical improvements than other techniques.
Povidone-iodine based skin preparation left substantial residual bacterial contamination at foot sites and did not reliably eliminate pathogens.
Povidone-iodine based skin preparation left substantial residual bacterial contamination at foot sites and did not reliably eliminate pathogens.
Povidone-iodine based skin preparation left substantial residual bacterial contamination at foot sites and did not reliably eliminate pathogens.
Adults randomized to water gargling, povidone-iodine gargling, or usual care; water gargling reduced new URTIs.
Adults randomized to water gargling, povidone-iodine gargling, or usual care; water gargling reduced new URTIs.
Adults randomized to water gargling, povidone-iodine gargling, or usual care; water gargling reduced new URTIs.
Small randomized clinical proof-of-concept in patients with mesh grafts showing the PVP-I liposome hydrogel improved antimicrobial effect and wound epithelial healing.
Small randomized clinical proof-of-concept in patients with mesh grafts showing the PVP-I liposome hydrogel improved antimicrobial effect and wound epithelial healing.
Small randomized clinical proof-of-concept in patients with mesh grafts showing the PVP-I liposome hydrogel improved antimicrobial effect and wound epithelial healing.
Among HPV-positive women who attended follow-up, adding Lugol's iodine to VIA increased sensitivity for detecting CIN2+ but was not statistically superior to VIA alone in this underpowered sample.
Among HPV-positive women who attended follow-up, adding Lugol's iodine to VIA increased sensitivity for detecting CIN2+ but was not statistically superior to VIA alone in this underpowered sample.
Among HPV-positive women who attended follow-up, adding Lugol's iodine to VIA increased sensitivity for detecting CIN2+ but was not statistically superior to VIA alone in this underpowered sample.
All patients received 5% povidone-iodine preoperatively; mupirocin nasal ointment markedly reduced conjunctival culture positivity compared with control.
All patients received 5% povidone-iodine preoperatively; mupirocin nasal ointment markedly reduced conjunctival culture positivity compared with control.
Large randomized trial showed chlorhexidine+alcohol reduced catheter colonization and local infections compared with povidone-iodine+alcohol; device innovations increased catheter dwell time.
Large randomized trial showed chlorhexidine+alcohol reduced catheter colonization and local infections compared with povidone-iodine+alcohol; device innovations increased catheter dwell time.
Large randomized trial showed chlorhexidine+alcohol reduced catheter colonization and local infections compared with povidone-iodine+alcohol; device innovations increased catheter dwell time.
Higher iodine concentration in contrast agent produced stronger CT enhancement of abdominal vessels and pancreas but did not improve detection of hypovascular pancreatic tumors.
Higher iodine concentration in contrast agent produced stronger CT enhancement of abdominal vessels and pancreas but did not improve detection of hypovascular pancreatic tumors.
A double-low CT protocol reduced radiation and iodine dose while maintaining similar image quality for aortic CTA.
Povidone-iodine and chlorhexidine had similar nasal decolonization efficacy; povidone-iodine caused more nasal discomfort.
Povidone-iodine and chlorhexidine had similar nasal decolonization efficacy; povidone-iodine caused more nasal discomfort.
Povidone-iodine and chlorhexidine had similar nasal decolonization efficacy; povidone-iodine caused more nasal discomfort.
A PVP-iodine liposomal hydrogel accelerated wound epithelialization, improved healing quality and reduced graft loss compared with chlorhexidine gauze.
A PVP-iodine liposomal hydrogel accelerated wound epithelialization, improved healing quality and reduced graft loss compared with chlorhexidine gauze.
Using povidone-iodine (betadine) vaginal scrub left in place during egg retrieval did not change most IVF outcomes but was associated with a higher chemical pregnancy rate.
Using povidone-iodine (betadine) vaginal scrub left in place during egg retrieval did not change most IVF outcomes but was associated with a higher chemical pregnancy rate.
Chlorhexidine-containing rinses were more effective than povidone-iodine mouthwash for reducing surgery-related oral malodor in the first postoperative week.
Chlorhexidine-containing rinses were more effective than povidone-iodine mouthwash for reducing surgery-related oral malodor in the first postoperative week.
Pregnant women given 150 µg/day iodine had higher urinary iodine but no clear differences in child development or thyroid hormones at follow-up.
Pregnant women given 150 µg/day iodine had higher urinary iodine but no clear differences in child development or thyroid hormones at follow-up.
Pregnant women given 150 µg/day iodine had higher urinary iodine but no clear differences in child development or thyroid hormones at follow-up.
Hydrofiber Ag dressings led to better pain management, comfort and exudate handling than povidone-iodine gauze; healing rates were numerically higher but not statistically significant.
Hydrofiber Ag dressings led to better pain management, comfort and exudate handling than povidone-iodine gauze; healing rates were numerically higher but not statistically significant.
Hydrofiber Ag dressings led to better pain management, comfort and exudate handling than povidone-iodine gauze; healing rates were numerically higher but not statistically significant.
0.5% PVP-I rinse produced lower postoperative pain, less mucosal irritation and less staining than 0.12% CHX with similar early wound healing.
0.5% PVP-I rinse produced lower postoperative pain, less mucosal irritation and less staining than 0.12% CHX with similar early wound healing.
0.5% PVP-I rinse produced lower postoperative pain, less mucosal irritation and less staining than 0.12% CHX with similar early wound healing.
A single 2.5% povidone-iodine ophthalmic drop at birth reduced infectious neonatal conjunctivitis compared with silver nitrate or erythromycin and had lower noninfectious conjunctivitis rates.
A single 2.5% povidone-iodine ophthalmic drop at birth reduced infectious neonatal conjunctivitis compared with silver nitrate or erythromycin and had lower noninfectious conjunctivitis rates.
In clean-contaminated surgery, aqueous povidone-iodine was associated with higher 30-day SSI (13%) than olanexidine (7%); adverse skin reactions were similar.
In clean-contaminated surgery, aqueous povidone-iodine was associated with higher 30-day SSI (13%) than olanexidine (7%); adverse skin reactions were similar.
In patients after high-dose chemotherapy, diluted povidone-iodine mouthwash showed no benefit over saline for mouth sores and was less well tolerated.
In patients after high-dose chemotherapy, diluted povidone-iodine mouthwash showed no benefit over saline for mouth sores and was less well tolerated.
In patients after high-dose chemotherapy, diluted povidone-iodine mouthwash showed no benefit over saline for mouth sores and was less well tolerated.
Regular povidone-iodine ointment at catheter exit sites delayed early dialysis-related infections and greatly reduced Staphylococcus aureus infections during the first 140 days.
Regular povidone-iodine ointment at catheter exit sites delayed early dialysis-related infections and greatly reduced Staphylococcus aureus infections during the first 140 days.
In middle-aged and elderly patients with endemic goitre, daily iodide reduced thyroid volume over 12 months by about 16%, similar to levothyroxine, without inducing thyroid antibodies.
In this small pilot, povidone-iodine applied intermittently after dental rehab did not significantly change S. mutans suppression at 6 months versus control, but showed a non-significant trend to fewer new caries at 1 year.
In this small pilot, povidone-iodine applied intermittently after dental rehab did not significantly change S. mutans suppression at 6 months versus control, but showed a non-significant trend to fewer new caries at 1 year.
Povidone-iodine mouth rinse showed a large median drop in salivary SARS-CoV-2 RNA at 60 min versus no-rinse, but only a small number of PVP‑I patients were analyzed.
A PVP‑iodine hydrogel dressing (Repithel) sped graft epithelialization and lowered graft loss compared with standard dressing.
Iodine-impregnated dressing (Inadine) showed no advantage over non-iodine dressings for ulcer healing at 24 weeks; costs differed between products.
A PVP‑iodine hydrogel dressing (Repithel) sped graft epithelialization and lowered graft loss compared with standard dressing.
A PVP‑iodine hydrogel dressing (Repithel) sped graft epithelialization and lowered graft loss compared with standard dressing.
Iodide substitution after thyroid surgery was as effective as L‑thyroxine at preventing goiter recurrence over one year.
Early repeated PVP‑I gargling increased saliva viral clearance at day 5 and reduced detectable infectious virus compared with later gargling with water then PVP‑I.
Early repeated PVP‑I gargling increased saliva viral clearance at day 5 and reduced detectable infectious virus compared with later gargling with water then PVP‑I.
In this pilot RCT, intraoperative povidone‑iodine irrigation showed a probable reduction in postoperative abscesses and shorter hospital stays.
In this pilot RCT, intraoperative povidone‑iodine irrigation showed a probable reduction in postoperative abscesses and shorter hospital stays.
Comparing two iodine-containing contrast agents, iodixanol-320 required a different flow/iodine-delivery protocol to reach equivalent arterial enhancement.
Comparing two iodine-containing contrast agents, iodixanol-320 required a different flow/iodine-delivery protocol to reach equivalent arterial enhancement.
Preoperative vaginal preparation with povidone‑iodine halved postcesarean endometritis compared with no vaginal prep.
Preoperative vaginal preparation with povidone‑iodine halved postcesarean endometritis compared with no vaginal prep.
Rectal cleansing with 10% povidone-iodine plus formalin dipping of the needle tip reduced infectious complications after transrectal prostate biopsy.
Rectal cleansing with 10% povidone-iodine plus formalin dipping of the needle tip reduced infectious complications after transrectal prostate biopsy.
Gadolinium-based contrast with dual-energy reconstructions can yield good pulmonary CT angiography; iodine-based iohexol gave highest attenuation but more SVC artifacts.
Alcoholic povidone-iodine skin disinfection reduced catheter colonization and catheter-related infection compared with aqueous povidone-iodine in an ICU unit-crossover trial.
Using 2% chlorhexidine in alcohol for skin disinfection was associated with a lower risk of catheter-related infection compared with alcoholic povidone-iodine in ICU patients.
In ICU adults, chlorhexidine-alcohol reduced short-term catheter-related infections versus povidone-iodine-alcohol; scrubbing provided no benefit and chlorhexidine caused more skin reactions.
Room-temperature iodinated contrast was noninferior to prewarmed contrast for abdominal CT image quality and produced slightly higher liver attenuation and better comfort.
Room-temperature iodinated contrast was noninferior to prewarmed contrast for abdominal CT image quality and produced slightly higher liver attenuation and better comfort.
Alcoholic povidone-iodine skin disinfection reduced catheter colonization and catheter-related infection compared with aqueous povidone-iodine in an ICU unit-crossover trial.
Alcohol-based chlorhexidine (0.5% and 1.0%) reduced catheter-tip colonization compared with 10% aqueous povidone-iodine; no significant difference in bloodstream infection rates.
Alcoholic povidone-iodine skin disinfection reduced catheter colonization and catheter-related infection compared with aqueous povidone-iodine in an ICU unit-crossover trial.
A single application of 10% povidone-iodine reduced oral mutans streptococci and lactobacilli for up to 3 months but did not reduce new caries at one year.
A single application of 10% povidone-iodine reduced oral mutans streptococci and lactobacilli for up to 3 months but did not reduce new caries at one year.
A single application of 10% povidone-iodine reduced oral mutans streptococci and lactobacilli for up to 3 months but did not reduce new caries at one year.
Applying 20 cc povidone-iodine gel at the vaginal apex modestly lowered overall post-operative infections and prevented pelvic abscess after abdominal hysterectomy.
Applying 20 cc povidone-iodine gel at the vaginal apex modestly lowered overall post-operative infections and prevented pelvic abscess after abdominal hysterectomy.
Applying 20 cc povidone-iodine gel at the vaginal apex modestly lowered overall post-operative infections and prevented pelvic abscess after abdominal hysterectomy.
Needleless connectors had lower internal luer contamination than standard caps; disinfecting connectors with povidone-iodine or chlorhexidine/alcohol reduced external contamination compared with isopropyl alcohol.
Needleless connectors had lower internal luer contamination than standard caps; disinfecting connectors with povidone-iodine or chlorhexidine/alcohol reduced external contamination compared with isopropyl alcohol.
Povidone-iodine enemas had similar infection rates to sodium hypochlorite but were better tolerated with less abdominal pain and fewer discontinuations.
Povidone-iodine enemas had similar infection rates to sodium hypochlorite but were better tolerated with less abdominal pain and fewer discontinuations.
Povidone-iodine enemas had similar infection rates to sodium hypochlorite but were better tolerated with less abdominal pain and fewer discontinuations.
Two long-term dietary patterns affected several serum minerals over 24 months; serum calcium showed no significant change while other minerals (selenium, manganese, magnesium) increased and serum zinc decreased.
Fortified salt containing iodine and other micronutrients given to children and women for 8 months improved iron and zinc status and reduced anemia; urinary iodine was maintained in the fortified group.
A prospective randomized study comparing low iodine dose/injection rate and low radiation (with AI denoising) versus standard protocol showed higher vascular CT attenuation, lower iodine intake, and substantially lower radiation dose with maintained diagnostic image quality.
Randomized double-blind multicenter trial found povidone iodine and dequalinium chloride equivalently improved vaginal infection symptoms with good tolerability.
Randomized double-blind multicenter trial found povidone iodine and dequalinium chloride equivalently improved vaginal infection symptoms with good tolerability.
In children receiving epidural catheters, skin prep with alcoholic chlorhexidine yielded fewer catheter colonizations than aqueous povidone iodine.
Comparing full-mouth versus quadrant-wise debridement (including a povidone-iodine arm), full-mouth treatments caused immediate rises in IL-6 and decreases in soluble thrombomodulin, indicating greater short-term systemic vascular effects.
Comparing full-mouth versus quadrant-wise debridement (including a povidone-iodine arm), full-mouth treatments caused immediate rises in IL-6 and decreases in soluble thrombomodulin, indicating greater short-term systemic vascular effects.
Compared visual inspection with acetic acid (VIA) and Lugol's iodine (VILI); VILI was less accurate than VIA, especially in HIV-positive women.
Compared visual inspection with acetic acid (VIA) and Lugol's iodine (VILI); VILI was less accurate than VIA, especially in HIV-positive women.
A single-application povidone-iodine applicator used much less solution and was non-inferior to conventional sterilization for wound infection after abdominal surgery.
A single-application povidone-iodine applicator used much less solution and was non-inferior to conventional sterilization for wound infection after abdominal surgery.
Topical povidone-iodine (betadine) and clotrimazole had similar recovery rates for otomycosis at days 4, 10 and 20.
Topical povidone-iodine (betadine) and clotrimazole had similar recovery rates for otomycosis at days 4, 10 and 20.
Topical povidone-iodine (betadine) and clotrimazole had similar recovery rates for otomycosis at days 4, 10 and 20.
Adding povidone-iodine to standard antibiotic therapy for corneal ulcers did not improve visual outcomes at 2–4 months.
Adding povidone-iodine to standard antibiotic therapy for corneal ulcers did not improve visual outcomes at 2–4 months.
Adding povidone-iodine to standard antibiotic therapy for corneal ulcers did not improve visual outcomes at 2–4 months.
Combining systemic cefuroxime with povidone-iodine spray reduced stomal infections after PEG more than either treatment alone.
Combining systemic cefuroxime with povidone-iodine spray reduced stomal infections after PEG more than either treatment alone.
No significant difference between 10% povidone-iodine and 0.5% chlorhexidine for prevention of catheter-related bacteremia or colonization; trend toward fewer exit-site infections with chlorhexidine.
No significant difference between 10% povidone-iodine and 0.5% chlorhexidine for prevention of catheter-related bacteremia or colonization; trend toward fewer exit-site infections with chlorhexidine.
No significant difference between 10% povidone-iodine and 0.5% chlorhexidine for prevention of catheter-related bacteremia or colonization; trend toward fewer exit-site infections with chlorhexidine.
In infertile women, management guided by HyFoSy or HSG produced similar live-birth rates, while HyFoSy caused significantly less pain.
Randomized study comparing povidone‑iodine lavage + lidocaine gel vs ceftriaxone + lavage for prostate biopsy; no difference in pain or infection rates.
Randomized study comparing povidone‑iodine lavage + lidocaine gel vs ceftriaxone + lavage for prostate biopsy; no difference in pain or infection rates.
Randomized placebo‑controlled pilot trial in hospitalized COVID‑19 patients: PVP‑I 1% mouthrinse produced the largest immediate reduction in oral SARS‑CoV‑2 RNA compared with other rinses and placebo.
Randomized placebo‑controlled pilot trial in hospitalized COVID‑19 patients: PVP‑I 1% mouthrinse produced the largest immediate reduction in oral SARS‑CoV‑2 RNA compared with other rinses and placebo.
Prospective randomized trial before cesarean: povidone‑iodine vaginal prep reduced aerobic and anaerobic bacterial colony counts more than chlorhexidine or saline.
Randomized study showed adding iodinated hyperosmolar contrast (Gastrografin) and/or effervescent agent to barium shortens small bowel transit time without reducing exam quality.
Large cohort used to derive and validate a preprocedural risk score for unplanned postprocedural renal replacement therapy following invasive coronary procedures involving iodinated contrast exposure.
Large cohort used to derive and validate a preprocedural risk score for unplanned postprocedural renal replacement therapy following invasive coronary procedures involving iodinated contrast exposure.
Randomized, blinded trial assessing remote ischemic preconditioning (RIPC) vs sham before coronary angiography: biomarker responses favored RIPC, suggesting nephroprotection against contrast‑induced injury.
Randomized, blinded trial assessing remote ischemic preconditioning (RIPC) vs sham before coronary angiography: biomarker responses favored RIPC, suggesting nephroprotection against contrast‑induced injury.
Randomized trial after mastectomy comparing talc, povidone‑iodine and standard care; iodine arm was stopped for increased drain output; talc did not reduce seroma frequency.
Randomized trial after mastectomy comparing talc, povidone‑iodine and standard care; iodine arm was stopped for increased drain output; talc did not reduce seroma frequency.
Randomized trial after mastectomy comparing talc, povidone‑iodine and standard care; iodine arm was stopped for increased drain output; talc did not reduce seroma frequency.
Multicentre randomized study in cataract patients comparing diluted povidone‑iodine vs polyvinyl alcohol‑iodine and different durations of topical levofloxacin; 3‑day levofloxacin plus iodine wash gave best disinfection.
Multicentre randomized study in cataract patients comparing diluted povidone‑iodine vs polyvinyl alcohol‑iodine and different durations of topical levofloxacin; 3‑day levofloxacin plus iodine wash gave best disinfection.
Randomized trial comparing routine pin‑site care with additional antiseptics (including povidone‑iodine); no antiseptic improved pin‑site infection rates over control.
Randomized trial comparing routine pin‑site care with additional antiseptics (including povidone‑iodine); no antiseptic improved pin‑site infection rates over control.
Randomized study of standard preoperative prep with povidone‑iodine with or without added alcohol for foot/ankle surgery; addition of alcohol did not reduce residual aerobic cultures.
Randomized trial comparing reduced‑concentration (1.25%) povidone‑iodine plus levofloxacin versus standard 5% PI before intravitreal injection; similar reductions in conjunctival culture positivity.
Randomized trial comparing reduced‑concentration (1.25%) povidone‑iodine plus levofloxacin versus standard 5% PI before intravitreal injection; similar reductions in conjunctival culture positivity.
Randomized comparison of hydrogel dressing versus standard conservative care (gauze with povidone‑iodine) for pressure ulcers in spinal‑cord injury patients; hydrogel increased epithelialisation rate.
Randomized comparison of hydrogel dressing versus standard conservative care (gauze with povidone‑iodine) for pressure ulcers in spinal‑cord injury patients; hydrogel increased epithelialisation rate.
Randomized prospective study in Kenya comparing eye prophylaxis agents in newborns; maternal vaginitis raised risk of gonococcal eye infection.
Randomized prospective study in Kenya comparing eye prophylaxis agents in newborns; maternal vaginitis raised risk of gonococcal eye infection.
Randomized prospective study in Kenya comparing eye prophylaxis agents in newborns; maternal vaginitis raised risk of gonococcal eye infection.
6-week RCT in healthy men replacing most red/processed meat with legumes; studied nutrient intakes and biomarkers including iodine intake and urinary iodine excretion.
6-week RCT in healthy men replacing most red/processed meat with legumes; studied nutrient intakes and biomarkers including iodine intake and urinary iodine excretion.
4-year prospective, blinded study where each patient received both textured and smooth implants and saline or Betadine irrigation to assess capsular contracture incidence.
4-year prospective, blinded study where each patient received both textured and smooth implants and saline or Betadine irrigation to assess capsular contracture incidence.
4-year prospective, blinded study where each patient received both textured and smooth implants and saline or Betadine irrigation to assess capsular contracture incidence.
Wet silver dressings healed skin wounds faster, reduced dressing changes and pain compared with povidone-iodine dressings.
Test bolus curve parameters (PD and AUC) and patient weight predict main-bolus contrast density in cardiac CT.
Both 1% and 5% PVP-I preparations similarly reduced recoverable organisms from donor eyes; 1% is preferred to limit toxicity.
Both 1% and 5% PVP-I preparations similarly reduced recoverable organisms from donor eyes; 1% is preferred to limit toxicity.
Iomeprol 400 (higher iodine concentration) produced greater arterial attenuation on 16-row CT than iopromide 370.
2.5% povidone-iodine (betadine) eye drops reduced newborn conjunctivitis compared with erythromycin or no prophylaxis.
No difference in catheter-related bloodstream infection between chlorhexidine-alcohol and povidone-iodine, but povidone-iodine was linked to more thyroid dysfunction.
No difference in catheter-related bloodstream infection between chlorhexidine-alcohol and povidone-iodine, but povidone-iodine was linked to more thyroid dysfunction.
Povidone-iodine preparation before intravitreal injection reduced conjunctival bacterial cultures to low rates; 3-day topical gatifloxacin lowered pre-prep flora but provided no additional benefit after povidone-iodine.
Povidone-iodine preparation before intravitreal injection reduced conjunctival bacterial cultures to low rates; 3-day topical gatifloxacin lowered pre-prep flora but provided no additional benefit after povidone-iodine.
150 patients randomized to postoperative levothyroxine (LT4) vs no LT4 after thyroid lobectomy: over 20 years LT4 greatly reduced recurrence of nodular goiter and need for further surgery, especially in iodine-deficient patients.
150 patients randomized to postoperative levothyroxine (LT4) vs no LT4 after thyroid lobectomy: over 20 years LT4 greatly reduced recurrence of nodular goiter and need for further surgery, especially in iodine-deficient patients.
150 patients randomized to postoperative levothyroxine (LT4) vs no LT4 after thyroid lobectomy: over 20 years LT4 greatly reduced recurrence of nodular goiter and need for further surgery, especially in iodine-deficient patients.
In lumbar fusion surgery, intraoperative povidone-iodine soaking reduced superficial tissue bacterial contamination but not deep tissues or implants; chlorhexidine soaked implants showed the greatest reduction of implant contamination; SSI rates were low and similar.
In lumbar fusion surgery, intraoperative povidone-iodine soaking reduced superficial tissue bacterial contamination but not deep tissues or implants; chlorhexidine soaked implants showed the greatest reduction of implant contamination; SSI rates were low and similar.
Large multicenter randomized trial found no difference between chlorhexidine-alcohol and povidone-iodine-alcohol for reoperation, surgical site infection, mediastinitis, or mortality after major cardiac surgery.
Large multicenter randomized trial found no difference between chlorhexidine-alcohol and povidone-iodine-alcohol for reoperation, surgical site infection, mediastinitis, or mortality after major cardiac surgery.
Repeated 1% povidone-iodine irrigations on the eye reduced bacteria and caused less corneal surface damage than a single 5% application.
Repeated 1% povidone-iodine irrigations on the eye reduced bacteria and caused less corneal surface damage than a single 5% application.
Uniphasic contrast injection gave better hepatic enhancement than biphasic; lower iodine doses can still give adequate enhancement, especially in thinner patients.
Uniphasic contrast injection gave better hepatic enhancement than biphasic; lower iodine doses can still give adequate enhancement, especially in thinner patients.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Spraying 2% vitamin C after Lugol iodine reduced acute and late mucosal irritation and sped fading of the iodine stain compared with saline; effects were similar or better than sodium thiosulfate for several symptoms.
Higher-concentration iodine contrast (370 mg I/mL) produced substantially greater vascular enhancement and higher image-quality scores than lower concentration (300 mg I/mL) with similar adverse reactions and modest cost savings.
Higher-concentration iodine contrast (370 mg I/mL) produced substantially greater vascular enhancement and higher image-quality scores than lower concentration (300 mg I/mL) with similar adverse reactions and modest cost savings.
Higher-concentration iodine contrast (370 mg I/mL) produced substantially greater vascular enhancement and higher image-quality scores than lower concentration (300 mg I/mL) with similar adverse reactions and modest cost savings.
Higher-concentration iodine contrast (370 mg I/mL) produced substantially greater vascular enhancement and higher image-quality scores than lower concentration (300 mg I/mL) with similar adverse reactions and modest cost savings.
Higher-concentration iodine contrast (370 mg I/mL) produced substantially greater vascular enhancement and higher image-quality scores than lower concentration (300 mg I/mL) with similar adverse reactions and modest cost savings.
Betadine cold sore paint markedly reduced detectable infectious HSV on lip lesions at 2 hours compared with Stoxil topical ointment.
Preoperative vaginal douching with 1% povidone-iodine reduced postoperative infectious morbidity after total abdominal hysterectomy compared with no douching.
Giving a second povidone-iodine eye drop within the first day did not reduce neonatal conjunctivitis compared with a single drop; double dosing had slightly more eyelid swelling.
Giving a second povidone-iodine eye drop within the first day did not reduce neonatal conjunctivitis compared with a single drop; double dosing had slightly more eyelid swelling.
Povidone-iodine (alcohol or aqueous) performed similarly to chlorhexidine-alcohol for 30-day surgical site infection, complications, and hospital stay after colorectal surgery.
Povidone-iodine (alcohol or aqueous) performed similarly to chlorhexidine-alcohol for 30-day surgical site infection, complications, and hospital stay after colorectal surgery.
Povidone-iodine and chlorhexidine procedures had comparable rapid in vivo bactericidal activity on skin flora up to 2 hours after application.
Povidone-iodine and chlorhexidine procedures had comparable rapid in vivo bactericidal activity on skin flora up to 2 hours after application.
Adding topical levofloxacin before povidone-iodine irrigation reduced conjunctival bacterial cultures more than povidone-iodine irrigation alone in patients undergoing intraocular surgery.
Adding topical levofloxacin before povidone-iodine irrigation reduced conjunctival bacterial cultures more than povidone-iodine irrigation alone in patients undergoing intraocular surgery.
Different povidone-iodine–based periocular preparation techniques did not meaningfully change needle or suture contamination rates during strabismus surgery.
Intraoperative diluted betadine irrigation was associated with no infected wounds compared with two superficial infections in the no-irrigation group.
Randomized trial comparing povidone-iodine versus soap+methylated spirit for skin prep before hernia repair; infection rates were similar.
Iodopovidone and doxycycline had similar pleurodesis success rates; iodopovidone caused higher chest pain scores but similar complication rates.
Iodopovidone and doxycycline had similar pleurodesis success rates; iodopovidone caused higher chest pain scores but similar complication rates.
Povidone-iodine had similar short-term efficacy but was 6% less effective than chloramphenicol from days 3–15 and nearly doubled risk of chlamydial conjunctivitis.
Povidone-iodine had similar short-term efficacy but was 6% less effective than chloramphenicol from days 3–15 and nearly doubled risk of chlamydial conjunctivitis.
Povidone-iodine had similar short-term efficacy but was 6% less effective than chloramphenicol from days 3–15 and nearly doubled risk of chlamydial conjunctivitis.
Topical 0.1% PVP-iodine used with mechanical therapy improved pocket depth and attachment level gains compared with mechanical therapy alone.
Topical 0.1% PVP-iodine used with mechanical therapy improved pocket depth and attachment level gains compared with mechanical therapy alone.
Topical 0.1% PVP-iodine used with mechanical therapy improved pocket depth and attachment level gains compared with mechanical therapy alone.
In a randomized wound dressing trial, hypochlorous acid (100 μg/mL) reduced bacterial load and promoted granulation better than povidone-iodine dressings.
In a randomized wound dressing trial, hypochlorous acid (100 μg/mL) reduced bacterial load and promoted granulation better than povidone-iodine dressings.
In infertile women, management guided by HyFoSy or HSG produced similar live-birth rates, while HyFoSy caused significantly less pain.
In infertile women, management guided by HyFoSy or HSG produced similar live-birth rates, while HyFoSy caused significantly less pain.
Randomized trial in COVID-19 outpatients found nasal irrigation with 1% PVP-I plus hypertonic alkaline solution reduced nasopharyngeal viral load more than other arms.
Randomized trial in COVID-19 outpatients found nasal irrigation with 1% PVP-I plus hypertonic alkaline solution reduced nasopharyngeal viral load more than other arms.
In ICU adults, chlorhexidine-alcohol reduced short-term catheter-related infections versus povidone-iodine-alcohol; scrubbing provided no benefit and chlorhexidine caused more skin reactions.
In ICU adults, chlorhexidine-alcohol reduced short-term catheter-related infections versus povidone-iodine-alcohol; scrubbing provided no benefit and chlorhexidine caused more skin reactions.
Aqueous povidone-iodine had higher catheter colonization (24.7%) than chlorhexidine solutions (~14–16%); bacteremia rates were similar across groups.
In this small neonatal pilot RCT, catheter colonization rates were similar between povidone-iodine and chlorhexidine groups; no dermatitis observed at chlorhexidine sites and chlorhexidine was detectable in some infants' blood.
In this small neonatal pilot RCT, catheter colonization rates were similar between povidone-iodine and chlorhexidine groups; no dermatitis observed at chlorhexidine sites and chlorhexidine was detectable in some infants' blood.
Topical 5% povidone-iodine ear drops were similarly effective to ciprofloxacin drops for chronic suppurative otitis media (approx. 88% vs 90% clinical improvement) and showed no in vitro resistance.
Topical 5% povidone-iodine ear drops were similarly effective to ciprofloxacin drops for chronic suppurative otitis media (approx. 88% vs 90% clinical improvement) and showed no in vitro resistance.
Crossover trial in NICU nurses found alcohol rub and povidone-iodine scrub reduced hand bacterial counts more than plain soap.
Small randomized study where intensive oral care including povidone-iodine gargle reduced oral bacterial species and was associated with fewer worsening pulmonary sounds.
Small randomized study where intensive oral care including povidone-iodine gargle reduced oral bacterial species and was associated with fewer worsening pulmonary sounds.
Among patients receiving radiotherapy, alcohol-free 1% povidone-iodine mouthwash reduced severity and delayed onset of oral mucositis compared with control.
Randomized trial showing povidone-iodine scrub reduces eyelid skin bacterial load similarly to baby shampoo and isopropyl alcohol.
Small randomized trial found a single application of 5% povidone-iodine did not reduce corneal ulcer bacterial load more than placebo/scraping.
Randomized study found nasal inhalation plus gargling with 1% PVP-I removed potentially pathogenic pharyngeal bacteria more often than gargling alone.
Randomized noninferiority study showing an iodine-only (Iopamidol) bowel-tagging regimen produced bowel cleansing comparable to an alternative minimal-prep regimen.
Randomized trial found 1% PVP-I mouthwash plus scaling/root planing improved clinical, microbial, and inflammatory periodontal indicators short-term and was not inferior to chlorhexidine while being better tolerated.
Soaking dropped ACL graft pieces in 10% povidone-iodine reduced but did not eliminate bacterial contamination.
Using a contrast containing 30 g of iodine, a monophasic 4 ml/s injection provided the best liver and portal vein enhancement on CT.
Using a contrast containing 30 g of iodine, a monophasic 4 ml/s injection provided the best liver and portal vein enhancement on CT.
Preprocedural mouthwashes (including 1% povidone-iodine) reduced the overall prevalence and number of detectable respiratory viruses in saliva, though no mouthwash was superior.
Preprocedural mouthwashes (including 1% povidone-iodine) reduced the overall prevalence and number of detectable respiratory viruses in saliva, though no mouthwash was superior.
Preoperative conjunctival irrigation with 5% povidone-iodine reduced conjunctival bacterial counts more than 1% povidone-iodine.
Large randomized trial comparing two iodine-based contrast agents (low-osmolar vs iso-osmolar) in high-risk patients; measured contrast-induced nephropathy (CIN), dialysis, and 30-day outcomes.
Large randomized trial comparing two iodine-based contrast agents (low-osmolar vs iso-osmolar) in high-risk patients; measured contrast-induced nephropathy (CIN), dialysis, and 30-day outcomes.
Randomized trial (n=40 COVID-19 patients) testing four mouthrinses including 0.5% povidone-iodine; primary outcome was reduction in salivary SARS-CoV-2 load at 15 minutes.
Randomized study in 60 laboring women comparing povidone iodine (PI) versus DuraPrep (iodophor in isopropyl alcohol) for skin antisepsis before epidural catheter insertion, assessing skin cultures and catheter colonization.
Randomized study in 60 laboring women comparing povidone iodine (PI) versus DuraPrep (iodophor in isopropyl alcohol) for skin antisepsis before epidural catheter insertion, assessing skin cultures and catheter colonization.
Randomized trial (n=36) comparing single-visit full-mouth ultrasonic debridement (one arm used povidone iodine) versus quadrant-wise therapy for chronic periodontitis; clinical and microbiological outcomes assessed up to 6 months.
Randomized trial (n=36) comparing single-visit full-mouth ultrasonic debridement (one arm used povidone iodine) versus quadrant-wise therapy for chronic periodontitis; clinical and microbiological outcomes assessed up to 6 months.
In this small randomized pilot, adding povidone-iodine dressing plus mupirocin did not clearly reduce exit-site infections compared to mupirocin alone; peritonitis occurred sooner in the dressing group.
Self-reported goiter (a proxy for iodine deficiency) was associated with about double the risk of noncardia gastric adenocarcinoma in this large cohort.
Self-reported goiter (a proxy for iodine deficiency) was associated with about double the risk of noncardia gastric adenocarcinoma in this large cohort.
Self-reported goiter (a proxy for iodine deficiency) was associated with about double the risk of noncardia gastric adenocarcinoma in this large cohort.
In obese patients, calculating lean body weight with the Boer formula to dose iodinated contrast resulted in higher liver enhancement than using the James formula.
In obese patients, calculating lean body weight with the Boer formula to dose iodinated contrast resulted in higher liver enhancement than using the James formula.
In obese patients, calculating lean body weight with the Boer formula to dose iodinated contrast resulted in higher liver enhancement than using the James formula.
In adults suspected of appendicitis, use of oral or IV iodinated contrast did not meaningfully improve diagnostic correctness or appendix visualization compared with reader variability.
In adults suspected of appendicitis, use of oral or IV iodinated contrast did not meaningfully improve diagnostic correctness or appendix visualization compared with reader variability.
Image fusion of pre-procedural CT and live fluoroscopy is feasible in TAVI and helped navigation without increasing iodinated contrast use or radiation exposure.
Image fusion of pre-procedural CT and live fluoroscopy is feasible in TAVI and helped navigation without increasing iodinated contrast use or radiation exposure.
Iodixanol and iohexol produced essentially equivalent image quality and safety profiles for adult excretory urography.
Iodixanol and iohexol produced essentially equivalent image quality and safety profiles for adult excretory urography.
In HCC patients receiving hepatic arterial chemotherapy with iodinated poppy seed oil emulsion, larger IPSO microdroplets led to substantially greater short-term declines in AFP.
Modeling based on the CLEAN trial indicates povidone-iodine (one-time application) was less effective and less cost-effective than chlorhexidine–alcohol at preventing catheter-related bloodstream infections in ICU patients.
Modeling based on the CLEAN trial indicates povidone-iodine (one-time application) was less effective and less cost-effective than chlorhexidine–alcohol at preventing catheter-related bloodstream infections in ICU patients.
Iodopovidone pleurodesis in malignant pleural effusion caused frequent adverse events and raised CRP; efficacy and quality of life were similar for 1% and 2% doses.
Iodopovidone pleurodesis in malignant pleural effusion caused frequent adverse events and raised CRP; efficacy and quality of life were similar for 1% and 2% doses.
Iodixanol had fewer mild-to-moderate adverse events and less injection pain than ioxaglate, with equivalent angiographic image quality.
Iodixanol had fewer mild-to-moderate adverse events and less injection pain than ioxaglate, with equivalent angiographic image quality.
In a small randomized study, CO2 contrast produced comparable angiographic images and clinical outcomes to iodine contrast without worsening kidney function and reduced contrast costs.
Iodixanol had fewer mild-to-moderate adverse events and less injection pain than ioxaglate, with equivalent angiographic image quality.
Higher iodine concentration in contrast material produced significantly higher vascular attenuation in the descending aorta and coronary arteries.
Using povidone-iodine for surgical hand rubbing reduced median bacterial counts but chlorhexidine reduced to zero; sterile water and brushes were not necessary.
Using povidone-iodine for surgical hand rubbing reduced median bacterial counts but chlorhexidine reduced to zero; sterile water and brushes were not necessary.
Randomized trial with >10-year follow-up (analyzed n=151) comparing total thyroidectomy alone vs with prophylactic central compartment lymph node dissection: no differences in oncologic outcomes or rates of permanent hypocalcemia or serum calcium at long-term follow-up.
Randomized trial with >10-year follow-up (analyzed n=151) comparing total thyroidectomy alone vs with prophylactic central compartment lymph node dissection: no differences in oncologic outcomes or rates of permanent hypocalcemia or serum calcium at long-term follow-up.
Double-masked pilot RCT in adults with adenoviral conjunctivitis: single in‑office 5% povidone‑iodine reduced viral load and hastened clinical improvement at day 4 compared with artificial tears.
Double-masked pilot RCT in adults with adenoviral conjunctivitis: single in‑office 5% povidone‑iodine reduced viral load and hastened clinical improvement at day 4 compared with artificial tears.
Double‑masked randomized study assessing safety/tolerability of one‑time 5% povidone‑iodine for adenoviral conjunctivitis: treatment was well tolerated with only transient corneal staining and no vision loss.
Double‑masked randomized study assessing safety/tolerability of one‑time 5% povidone‑iodine for adenoviral conjunctivitis: treatment was well tolerated with only transient corneal staining and no vision loss.
Triple‑blind RCT comparing povidone‑iodine, hydrogen peroxide, and chlorhexidine mouthrinses for pre‑procedural use: high satisfaction and acceptability overall and no difference between mouthrinses.
Triple‑blind RCT comparing povidone‑iodine, hydrogen peroxide, and chlorhexidine mouthrinses for pre‑procedural use: high satisfaction and acceptability overall and no difference between mouthrinses.
Randomized comparison of water (neutral) vs 2% iodinated enteral contrast in 40 patients: water improved detection of abnormal bowel wall enhancement and overall diagnostic accuracy, while iodinated contrast better visualized the ileocaecal junction.
Randomized comparison of water (neutral) vs 2% iodinated enteral contrast in 40 patients: water improved detection of abnormal bowel wall enhancement and overall diagnostic accuracy, while iodinated contrast better visualized the ileocaecal junction.
Randomized comparison of water (neutral) vs 2% iodinated enteral contrast in 40 patients: water improved detection of abnormal bowel wall enhancement and overall diagnostic accuracy, while iodinated contrast better visualized the ileocaecal junction.
Compared iopamidol and iodixanol in 122 diabetic patients undergoing angiography and found similar rates of contrast-induced nephropathy between agents.
Randomized clinical and phantom study (88 patients) showing 100 kVp CT protocol increases venous enhancement and CNR and allows comparable venous attenuation with ~19% less iodine compared with conventional 120 kVp.
Randomized clinical and phantom study (88 patients) showing 100 kVp CT protocol increases venous enhancement and CNR and allows comparable venous attenuation with ~19% less iodine compared with conventional 120 kVp.
Randomized clinical and phantom study (88 patients) showing 100 kVp CT protocol increases venous enhancement and CNR and allows comparable venous attenuation with ~19% less iodine compared with conventional 120 kVp.
Randomized trial in 40 patients comparing a super-oxidized wound solution to povidone iodine; the super-oxidized solution had higher healing rates and faster culture clearance than povidone iodine.
Randomized trial in 40 patients comparing a super-oxidized wound solution to povidone iodine; the super-oxidized solution had higher healing rates and faster culture clearance than povidone iodine.
Randomized trial in 40 patients comparing a super-oxidized wound solution to povidone iodine; the super-oxidized solution had higher healing rates and faster culture clearance than povidone iodine.
Prospective study of 140 patients comparing 370 vs 300 mgI/mL contrast (identical total iodine load) showing higher arterial enhancement with 300 mgI/mL, no venous difference, and increased SUV values with contrast-enhanced vs non-enhanced PET/CT.
Prospective study of 140 patients comparing 370 vs 300 mgI/mL contrast (identical total iodine load) showing higher arterial enhancement with 300 mgI/mL, no venous difference, and increased SUV values with contrast-enhanced vs non-enhanced PET/CT.
Prospective study of 140 patients comparing 370 vs 300 mgI/mL contrast (identical total iodine load) showing higher arterial enhancement with 300 mgI/mL, no venous difference, and increased SUV values with contrast-enhanced vs non-enhanced PET/CT.
A PVP-iodine liposomal hydrogel (Repithel) applied to mesh graft wounds sped healing and reduced graft loss versus lipid gauze alone.
A PVP-iodine liposomal hydrogel (Repithel) applied to mesh graft wounds sped healing and reduced graft loss versus lipid gauze alone.
A PVP-iodine liposomal hydrogel (Repithel) applied to mesh graft wounds sped healing and reduced graft loss versus lipid gauze alone.
Pre-cleaning skin with warm 5% NaHCO3 reduced patient pain and increased satisfaction versus 75% alcohol; bacterial counts after subsequent iodine disinfection were similar.
Pre-cleaning skin with warm 5% NaHCO3 reduced patient pain and increased satisfaction versus 75% alcohol; bacterial counts after subsequent iodine disinfection were similar.
Pre-cleaning skin with warm 5% NaHCO3 reduced patient pain and increased satisfaction versus 75% alcohol; bacterial counts after subsequent iodine disinfection were similar.
Using multiple micronutrient-fortified salt in school meals improved markers of iron status but did not change urinary iodine or serum ferritin over one year.
Mechanical plus povidone-iodine oral cleansing before surgery reduced detection rates and counts of several potential respiratory pathogens versus no oral cleansing.
Topical 2% povidone-iodine twice daily improved paronychia severity versus vehicle control and reduced nail pain in patients with cancer therapy-associated paronychia.
Topical 2% povidone-iodine twice daily improved paronychia severity versus vehicle control and reduced nail pain in patients with cancer therapy-associated paronychia.
In patients at risk for contrast-induced nephropathy, withholding prophylactic IV hydration was non-inferior to IV hydration for preventing creatinine-defined nephropathy after iodinated contrast and was cost-saving.
In ICU patients receiving ≥100 mL iodinated contrast, theophylline reduced incidence of contrast-induced nephropathy more than acetylcysteine.
In patients at risk for contrast-induced nephropathy, withholding prophylactic IV hydration was non-inferior to IV hydration for preventing creatinine-defined nephropathy after iodinated contrast and was cost-saving.
After Lugol's iodine staining during endoscopy, spraying 5% sodium thiosulfate reduced mucosal irritation lasting >30 minutes compared with no treatment.
Randomized comparison of two iodinated contrast agent concentrations showed similar diagnostic image quality; few transient adverse effects observed.
Randomized comparison of two iodinated contrast agent concentrations showed similar diagnostic image quality; few transient adverse effects observed.
Full-mouth ultrasonic debridement (including a povidone-iodine group) led to earlier reductions in some serum IgG titres and increased antibody avidity at 3 months in the povidone group.
Full-mouth ultrasonic debridement (including a povidone-iodine group) led to earlier reductions in some serum IgG titres and increased antibody avidity at 3 months in the povidone group.
In patients with bacterially burdened leg ulcers, cadexomer iodine and nanocrystalline silver produced comparable overall healing rates at 12 weeks, though silver showed faster early healing in certain wound subgroups.
In patients with bacterially burdened leg ulcers, cadexomer iodine and nanocrystalline silver produced comparable overall healing rates at 12 weeks, though silver showed faster early healing in certain wound subgroups.
In patients undergoing coronary angiography with iodinated contrast, nebivolol pretreatment showed a nonsignificant trend toward less creatinine rise and slightly lower CIN incidence versus controls.
In this multicenter pilot RCT of pediatric posterior spine fusion, povidone-iodine wound soak produced similar pre- and post-irrigation tissue culture positivity and similar short-term infection rates compared with sterile saline.
In this multicenter pilot RCT of pediatric posterior spine fusion, povidone-iodine wound soak produced similar pre- and post-irrigation tissue culture positivity and similar short-term infection rates compared with sterile saline.
In this multicenter pilot RCT of pediatric posterior spine fusion, povidone-iodine wound soak produced similar pre- and post-irrigation tissue culture positivity and similar short-term infection rates compared with sterile saline.
In neonates requiring central venous catheters, skin disinfection with 10% povidone-iodine was as effective as a chlorhexidine-impregnated dressing for preventing bloodstream infections, but had higher catheter-tip colonization and no contact dermatitis.
Preoperative vaginal cleansing with 1% povidone-iodine before unscheduled cesarean delivery did not reduce postoperative infectious morbidity compared with no vaginal cleansing.
Irrigation of spinal surgical wounds with dilute povidone-iodine (betadine) before closure markedly reduced postoperative wound infections compared with no betadine irrigation.
Irrigation of spinal surgical wounds with dilute povidone-iodine (betadine) before closure markedly reduced postoperative wound infections compared with no betadine irrigation.
Topical povidone-iodine and purified human placental extract produced similar overall wound healing after orthopaedic surgery, but povidone-iodine had more wound induration at day 7.
Topical povidone-iodine and purified human placental extract produced similar overall wound healing after orthopaedic surgery, but povidone-iodine had more wound induration at day 7.
In chemotherapy-induced oral mucositis, the povidone-iodine–containing antiseptic regimen (AA) was associated with longer symptom duration and slower lesion remission than topical GM-CSF.
In poorly controlled T2D patients, nonsurgical periodontal therapy including subgingival irrigation with 10% povidone-iodine significantly improved periodontal status and reduced HbA1c versus control.
In children with early childhood caries, topical 10% povidone-iodine applied twice significantly reduced S. mutans counts versus control, though fluoride varnish showed the greatest reduction.
Conjunctival disinfection with 5% povidone-iodine before vitreoretinal surgery produced near-complete bacterial eradication regardless of preoperative levofloxacin duration.
Topical povidone-iodine 0.6% combined with dexamethasone improved clinical resolution and accelerated adenoviral eradication versus vehicle in acute adenoviral conjunctivitis.
Topical povidone-iodine 0.6% combined with dexamethasone improved clinical resolution and accelerated adenoviral eradication versus vehicle in acute adenoviral conjunctivitis.
Topical povidone-iodine 0.6% combined with dexamethasone improved clinical resolution and accelerated adenoviral eradication versus vehicle in acute adenoviral conjunctivitis.
Compared Praneem tablets to Betadine (povidone-iodine) vaginal pessary in women with abnormal vaginal discharge; both reduced symptoms, Betadine relieved symptoms in 81.6% of women.
Compared Praneem tablets to Betadine (povidone-iodine) vaginal pessary in women with abnormal vaginal discharge; both reduced symptoms, Betadine relieved symptoms in 81.6% of women.
Compared Praneem tablets to Betadine (povidone-iodine) vaginal pessary in women with abnormal vaginal discharge; both reduced symptoms, Betadine relieved symptoms in 81.6% of women.
Randomized study of right vs left arm IV injection of iodinated contrast for head/neck CT; right-arm injection reduced perivenous artifacts and retrograde flow and produced slightly higher vascular attenuation (not statistically significant for CA/IJV).
Randomized study of right vs left arm IV injection of iodinated contrast for head/neck CT; right-arm injection reduced perivenous artifacts and retrograde flow and produced slightly higher vascular attenuation (not statistically significant for CA/IJV).
Randomized study of right vs left arm IV injection of iodinated contrast for head/neck CT; right-arm injection reduced perivenous artifacts and retrograde flow and produced slightly higher vascular attenuation (not statistically significant for CA/IJV).
Randomized trial comparing sesame oil, nitroglycerin ointment, and alcohol/Betadine for prevention of chemotherapy-induced phlebitis; no statistically significant differences between groups in phlebitis incidence.
Randomized trial comparing sesame oil, nitroglycerin ointment, and alcohol/Betadine for prevention of chemotherapy-induced phlebitis; no statistically significant differences between groups in phlebitis incidence.
Prospective recording of acute adverse reactions to five iodinated contrast agents in 8,931 CT patients; overall reaction rate 2.7% with higher rates for iomeprol (3.9%) and iopromide (3.5%).
Prospective recording of acute adverse reactions to five iodinated contrast agents in 8,931 CT patients; overall reaction rate 2.7% with higher rates for iomeprol (3.9%) and iopromide (3.5%).
Prospective recording of acute adverse reactions to five iodinated contrast agents in 8,931 CT patients; overall reaction rate 2.7% with higher rates for iomeprol (3.9%) and iopromide (3.5%).
Assessed point-of-care devices versus laboratory eGFR before IV iodinated contrast; POC devices were moderately accurate, did not miss high-risk patients but underreported some eGFR values.
Assessed point-of-care devices versus laboratory eGFR before IV iodinated contrast; POC devices were moderately accurate, did not miss high-risk patients but underreported some eGFR values.
Assessed point-of-care devices versus laboratory eGFR before IV iodinated contrast; POC devices were moderately accurate, did not miss high-risk patients but underreported some eGFR values.
Topical varnish containing 10% povidone-iodine + fluoride applied every 3 months reduced new caries in primary molars compared with fluoride alone; no harms reported.
Topical varnish containing 10% povidone-iodine + fluoride applied every 3 months reduced new caries in primary molars compared with fluoride alone; no harms reported.
Cord-blood substudy (n=333) of a large cluster-randomized trial comparing antenatal multiple micronutrient (MM) supplementation (includes vitamin D) versus iron–folic acid (IFA); MM increased newborn vitamin D, ferritin, and zinc vs IFA.
Cord-blood substudy (n=333) of a large cluster-randomized trial comparing antenatal multiple micronutrient (MM) supplementation (includes vitamin D) versus iron–folic acid (IFA); MM increased newborn vitamin D, ferritin, and zinc vs IFA.
Cord-blood substudy (n=333) of a large cluster-randomized trial comparing antenatal multiple micronutrient (MM) supplementation (includes vitamin D) versus iron–folic acid (IFA); MM increased newborn vitamin D, ferritin, and zinc vs IFA.
Topical levofloxacin for 1 or 3 days reduced conjunctival culture positivity similarly; subsequent application of 5% povidone‑iodine further reduced positive cultures to 20%.
Topical levofloxacin for 1 or 3 days reduced conjunctival culture positivity similarly; subsequent application of 5% povidone‑iodine further reduced positive cultures to 20%.
Phase 3 randomized trial: combination PVP‑I/DEX did not show statistically significant clinical or bacteriologic superiority to placebo at day 5 and had higher rates of treatment‑emergent adverse events.
Phase 3 randomized trial: combination PVP‑I/DEX did not show statistically significant clinical or bacteriologic superiority to placebo at day 5 and had higher rates of treatment‑emergent adverse events.
Phase 3 randomized trial: combination PVP‑I/DEX did not show statistically significant clinical or bacteriologic superiority to placebo at day 5 and had higher rates of treatment‑emergent adverse events.
Applying 10% povidone-iodine to teeth of high-risk toddlers markedly reduced early childhood caries over 12 months compared with placebo.
Improved oral care using 0.1% povidone-iodine (plus toothbrush and suction) reduced oral bacteria and lowered ventilator-associated pneumonia compared with routine saline care.
Improved oral care using 0.1% povidone-iodine (plus toothbrush and suction) reduced oral bacteria and lowered ventilator-associated pneumonia compared with routine saline care.
Improved oral care using 0.1% povidone-iodine (plus toothbrush and suction) reduced oral bacteria and lowered ventilator-associated pneumonia compared with routine saline care.
Iodopovidone used for chemical pleurodesis in malignant pleural effusion achieved high overall success (88.4%), with similar results using small or large tubes.
Iodopovidone used for chemical pleurodesis in malignant pleural effusion achieved high overall success (88.4%), with similar results using small or large tubes.
Using a lower-iodine concentration contrast agent produced image quality similar to a higher-iodine agent and had slightly fewer adverse events.
Different scrub protocols were compared; alcohol-based antiseptics and some antiseptic scrubs produced greater bacterial reductions and were not more damaging to skin.
Antiseptic soaps (including povidone iodine) and alcohol-based handrub reduced fingertip bacterial counts more than non-antiseptic soap; alcohol rub had the largest reduction.
Different scrub protocols were compared; alcohol-based antiseptics and some antiseptic scrubs produced greater bacterial reductions and were not more damaging to skin.
Different scrub protocols were compared; alcohol-based antiseptics and some antiseptic scrubs produced greater bacterial reductions and were not more damaging to skin.
Lower tube voltage plus iterative reconstruction allowed a ~26% lower iodine load and ~35% lower radiation dose while keeping image quality similar.
In high-risk PCI patients given iodinated contrast, IV prostaglandin E1 reduced the incidence of contrast-induced nephropathy versus control hydration alone.
Antiseptic soaps (including povidone iodine) and alcohol-based handrub reduced fingertip bacterial counts more than non-antiseptic soap; alcohol rub had the largest reduction.
Antiseptic soaps (including povidone iodine) and alcohol-based handrub reduced fingertip bacterial counts more than non-antiseptic soap; alcohol rub had the largest reduction.
Different iodine-containing CT contrast protocols were compared; high flow prewarmed contrast was safe and comfortable.
Different iodine-containing CT contrast protocols were compared; high flow prewarmed contrast was safe and comfortable.
Different iodine-containing CT contrast protocols were compared; high flow prewarmed contrast was safe and comfortable.
A cluster RCT in 342 pregnant women showed the P4HP empowerment programme modestly improved overall diet quality and some nutrient components by the third trimester.
A cluster RCT in 342 pregnant women showed the P4HP empowerment programme modestly improved overall diet quality and some nutrient components by the third trimester.
A cluster RCT in 342 pregnant women showed the P4HP empowerment programme modestly improved overall diet quality and some nutrient components by the third trimester.
Daily consumption of yoghurt fortified with multiple micronutrients (including iodine) for 12 months reduced declines in iodine status and improved hemoglobin and linear growth in schoolchildren.
Daily consumption of yoghurt fortified with multiple micronutrients (including iodine) for 12 months reduced declines in iodine status and improved hemoglobin and linear growth in schoolchildren.
Daily consumption of yoghurt fortified with multiple micronutrients (including iodine) for 12 months reduced declines in iodine status and improved hemoglobin and linear growth in schoolchildren.
Four iodinated CT contrast agents were compared for liver enhancement; enhancement profiles differed between agents.
Four iodinated CT contrast agents were compared for liver enhancement; enhancement profiles differed between agents.
In 306 patients randomized to iodixanol or iopromide for coronary CTA, lumen opacification and image quality were comparable and cardiovascular effects were monitored without major differences.
In 306 patients randomized to iodixanol or iopromide for coronary CTA, lumen opacification and image quality were comparable and cardiovascular effects were monitored without major differences.
Prospective double-blind randomized multicenter trial comparing two low-osmolar iodinated contrast agents for abdominal CT focusing on adverse events and diagnostic efficacy.
Randomized study in obese patients comparing conventional CT protocol vs a 'double-low' protocol (lower kVp and lower-concentration iodine) plus AIIR reconstruction, assessing image quality, radiation dose, and iodine intake.
Randomized study in obese patients comparing conventional CT protocol vs a 'double-low' protocol (lower kVp and lower-concentration iodine) plus AIIR reconstruction, assessing image quality, radiation dose, and iodine intake.
Large prospective randomized trials reporting endophthalmitis rates after intravitreal injections using a standardized protocol that included topical povidone-iodine but did not require topical antibiotics.
Large prospective randomized trials reporting endophthalmitis rates after intravitreal injections using a standardized protocol that included topical povidone-iodine but did not require topical antibiotics.
Neurosurgical patients given intra-arterial iodinated contrast had a high rate of kidney injury (~23%) with no difference between low- and iso-osmolar agents.
Neurosurgical patients given intra-arterial iodinated contrast had a high rate of kidney injury (~23%) with no difference between low- and iso-osmolar agents.
In a randomized trial of leg ulcer dressings, silver dressings improved early (first 2 weeks) healing compared with cadexomer iodine under certain low-burden bacterial conditions.
In a randomized trial of leg ulcer dressings, silver dressings improved early (first 2 weeks) healing compared with cadexomer iodine under certain low-burden bacterial conditions.
Using fusion imaging guidance did not significantly change radiation exposure or the volume of iodinated contrast used during lower extremity endovascular procedures.
Using fusion imaging guidance did not significantly change radiation exposure or the volume of iodinated contrast used during lower extremity endovascular procedures.
Increasing injectate volume (4, 6, 8 mL) did not change pain relief or disability outcomes, and the pattern of iodinated contrast spread was similar across volumes.
Increasing injectate volume (4, 6, 8 mL) did not change pain relief or disability outcomes, and the pattern of iodinated contrast spread was similar across volumes.
Using lower-concentration iodine contrast with lower tube voltage reduced radiation and kept acceptable image quality.
Using lower-concentration iodine contrast with lower tube voltage reduced radiation and kept acceptable image quality.
Preventive dental protocols (including topical sodium iodide) reduced cariogenic bacteria and candidosis compared with no preventive care, but chlorhexidine worked best.
Preventive dental protocols (including topical sodium iodide) reduced cariogenic bacteria and candidosis compared with no preventive care, but chlorhexidine worked best.
Preventive dental protocols (including topical sodium iodide) reduced cariogenic bacteria and candidosis compared with no preventive care, but chlorhexidine worked best.
In children with normal renal function, iobitridol was noninferior to iodixanol for creatinine clearance change and rates of contrast-induced nephropathy were not significantly different.
Povidone-iodine irrigation during wet-to-moist cleansing significantly reduced wound bacterial burden compared with saline.
At lower iodine doses, iodixanol provided higher diagnostic quality and less discomfort than iohexol in intravenous urography.
At lower iodine doses, iodixanol provided higher diagnostic quality and less discomfort than iohexol in intravenous urography.
At lower iodine doses, iodixanol provided higher diagnostic quality and less discomfort than iohexol in intravenous urography.
In healthy volunteers, iodixanol (dimer) at a lower iodine dose produced similar renal enhancement curves to iopromide (monomer), but produced higher renal pelvic density up to 10 minutes.
In healthy volunteers, iodixanol (dimer) at a lower iodine dose produced similar renal enhancement curves to iopromide (monomer), but produced higher renal pelvic density up to 10 minutes.
In patients with chronic renal insufficiency undergoing angiography, iodixanol did not significantly reduce renal deterioration compared with ioxaglate.
In patients with chronic renal insufficiency undergoing angiography, iodixanol did not significantly reduce renal deterioration compared with ioxaglate.
Post-hoc analysis (n=246) of patients receiving iodinated contrast media: MBL deficiency was associated with lower rates of early cystatin-C–based renal injury but not with creatinine-defined CIN.
Post-hoc analysis (n=246) of patients receiving iodinated contrast media: MBL deficiency was associated with lower rates of early cystatin-C–based renal injury but not with creatinine-defined CIN.
Post-hoc analysis (n=246) of patients receiving iodinated contrast media: MBL deficiency was associated with lower rates of early cystatin-C–based renal injury but not with creatinine-defined CIN.
Compared two iodine-containing contrast agents for safety and image quality; similar efficacy and safety, with fewer cases of contrast-related kidney injury after iosimenol.
Compared two iodine-containing contrast agents for safety and image quality; similar efficacy and safety, with fewer cases of contrast-related kidney injury after iosimenol.
In patients with chronic kidney disease undergoing procedures with iodinated contrast, adding systemic hypothermia did not reduce risk of contrast-induced kidney injury.
In patients with chronic kidney disease undergoing procedures with iodinated contrast, adding systemic hypothermia did not reduce risk of contrast-induced kidney injury.
Providing salt fortified with both iron and iodine increased dietary iron intake compared with iodine-only salt but did not change energy, other nutrient intakes, or anthropometric measures.
Providing salt fortified with both iron and iodine increased dietary iron intake compared with iodine-only salt but did not change energy, other nutrient intakes, or anthropometric measures.
Providing salt fortified with both iron and iodine increased dietary iron intake compared with iodine-only salt but did not change energy, other nutrient intakes, or anthropometric measures.
In a small randomized study, CO2 contrast produced comparable angiographic images and clinical outcomes to iodine contrast without worsening kidney function and reduced contrast costs.
In peritoneal dialysis patients, daily care with polyhexanide reduced exit-site infections compared with traditional saline plus povidone-iodine care.
In peritoneal dialysis patients, daily care with polyhexanide reduced exit-site infections compared with traditional saline plus povidone-iodine care.
In peritoneal dialysis patients, daily care with polyhexanide reduced exit-site infections compared with traditional saline plus povidone-iodine care.
Povidone-iodine hand scrub left more bacteria after surgical disinfection than chlorhexidine scrub or a waterless hand rub.
Povidone-iodine hand scrub left more bacteria after surgical disinfection than chlorhexidine scrub or a waterless hand rub.
Different iodinated contrast agents produced different pain and image quality during lower-limb angiography.
Different iodinated contrast agents produced different pain and image quality during lower-limb angiography.
Low-voltage CT angiography using a lower iodine dose provided reliable diagnostic images with less iodine exposure.
Low-voltage CT angiography using a lower iodine dose provided reliable diagnostic images with less iodine exposure.
Longer delay after contrast injection (60 s) increased liver enhancement; iodine dose and volume affected vascular attenuation.
Longer delay after contrast injection (60 s) increased liver enhancement; iodine dose and volume affected vascular attenuation.
Both ionic and non-ionic iodinated contrast agents reduced thrombin generation after diagnostic angiography with no differential effects between agents.
Both ionic and non-ionic iodinated contrast agents reduced thrombin generation after diagnostic angiography with no differential effects between agents.
In children after circumcision, application of wound induction gel resulted in fewer glans scabs and slightly faster wound healing than povidone-iodine application.
Randomized trial comparing radioactive I-125 seed-loaded biliary stents versus conventional stents found higher early postoperative biliary tract infection with the I-125 stent.
Randomized trial comparing radioactive I-125 seed-loaded biliary stents versus conventional stents found higher early postoperative biliary tract infection with the I-125 stent.
Observational analysis of diet in women with gestational diabetes found many had inadequate intakes of several nutrients including vitamin D.
Statistical analysis plan for a planned randomized cluster-crossover trial comparing 10% povidone-iodine versus 4% chlorhexidine for preventing surgical site infections in open fractures.
Twice‑RDA multiple micronutrient supplement (including iodine) for six months did not change 12‑month mortality, growth, or CD4 counts versus standard multivitamins.
In patients with moderately reduced renal function, post-angiography hemodialysis removed plasma contrast but did not reduce contrast-induced nephrotoxicity or change renal clearance outcomes.
In patients with moderately reduced renal function, post-angiography hemodialysis removed plasma contrast but did not reduce contrast-induced nephrotoxicity or change renal clearance outcomes.
In patients with moderately reduced renal function, post-angiography hemodialysis removed plasma contrast but did not reduce contrast-induced nephrotoxicity or change renal clearance outcomes.
In poorly controlled T2D patients, nonsurgical periodontal therapy including subgingival irrigation with 10% povidone-iodine significantly improved periodontal status and reduced HbA1c versus control.
Minocycline ointment produced greater improvement than the control treatment (10% iodine applied around teeth) in plaque index, probing depth, and sulcus bleeding index for early peri-implantitis.
Minocycline ointment produced greater improvement than the control treatment (10% iodine applied around teeth) in plaque index, probing depth, and sulcus bleeding index for early peri-implantitis.
Adding potassium bromide to methimazole produced faster symptom relief and normalized thyroid hormone levels more rapidly than methimazole alone.
Adding potassium bromide to methimazole produced faster symptom relief and normalized thyroid hormone levels more rapidly than methimazole alone.
Spectral CT at 60 keV with ASiR allowed about 25% less iodine contrast while maintaining or improving portal-venous image quality.
127 patients randomized to standard vs BMI-based individualized DECT CTPA: individualized protocol substantially reduced radiation and iodine doses (about 34% and ~57% respectively), improved SNR/CNR and reduced superior vena cava artifacts while maintaining or improving diagnostic image quality.
Spectral CT at 60 keV with ASiR allowed about 25% less iodine contrast while maintaining or improving portal-venous image quality.
Iodixanol and iohexol provided similar radiographic quality in children, but iodixanol caused fewer adverse events (mainly diarrhea).
Iodixanol and iohexol provided similar radiographic quality in children, but iodixanol caused fewer adverse events (mainly diarrhea).
Universal decolonization with chlorhexidine bathing plus nasal povidone-iodine reduced infection-related and all-cause hospital transfers among nursing home residents.
Universal decolonization with chlorhexidine bathing plus nasal povidone-iodine reduced infection-related and all-cause hospital transfers among nursing home residents.
Randomized trial testing extra preoperative umbilicus preparation (in addition to standard povidone-iodine skin disinfection) versus control for incision infection and healing after TU-LESS.
Randomized trial testing extra preoperative umbilicus preparation (in addition to standard povidone-iodine skin disinfection) versus control for incision infection and healing after TU-LESS.
Randomized trial testing extra preoperative umbilicus preparation (in addition to standard povidone-iodine skin disinfection) versus control for incision infection and healing after TU-LESS.
Prospective randomized study testing different volumes of iodine-containing contrast medium for high-pitch CT coronary angiography and effects on vessel attenuation and image quality.
Prospective randomized study testing different volumes of iodine-containing contrast medium for high-pitch CT coronary angiography and effects on vessel attenuation and image quality.
Prospective randomized study testing different volumes of iodine-containing contrast medium for high-pitch CT coronary angiography and effects on vessel attenuation and image quality.
Eating farmed Atlantic salmon three times weekly for 16 weeks increased EPA/DHA biomarkers and modestly improved two raw cognitive subtest scores but did not change global IQ scores in preschool children.
Eating farmed Atlantic salmon three times weekly for 16 weeks increased EPA/DHA biomarkers and modestly improved two raw cognitive subtest scores but did not change global IQ scores in preschool children.
Two double-blind randomized studies (216 patients) found no significant effects of different iodinated contrast media on heart rate or arterial/LV pressures, though non-serious adverse events were reported more often with iodixanol in coronary angiography.
Two double-blind randomized studies (216 patients) found no significant effects of different iodinated contrast media on heart rate or arterial/LV pressures, though non-serious adverse events were reported more often with iodixanol in coronary angiography.
Two double-blind randomized studies (216 patients) found no significant effects of different iodinated contrast media on heart rate or arterial/LV pressures, though non-serious adverse events were reported more often with iodixanol in coronary angiography.
In a double-blind crossover study of 50 patients, two iodinated contrast agents produced similar angiographic image quality; iodixanol caused a tendency toward less warmth on injection.
In a double-blind crossover study of 50 patients, two iodinated contrast agents produced similar angiographic image quality; iodixanol caused a tendency toward less warmth on injection.
Gadolinium-based contrast with dual-energy reconstructions can yield good pulmonary CT angiography; iodine-based iohexol gave highest attenuation but more SVC artifacts.
In a double-blind crossover study of 50 patients, two iodinated contrast agents produced similar angiographic image quality; iodixanol caused a tendency toward less warmth on injection.
Adding subcutaneous povidone-iodine disinfection during shoulder surgery significantly reduced positive cultures for C. acnes and overall microbial contamination.
Adding subcutaneous povidone-iodine disinfection during shoulder surgery significantly reduced positive cultures for C. acnes and overall microbial contamination.
Adding subcutaneous povidone-iodine disinfection during shoulder surgery significantly reduced positive cultures for C. acnes and overall microbial contamination.
In 120 patients, low-iodine-concentration contrast (iodixanol 270 mgI/ml) with low tube voltage and iterative reconstruction achieved comparable image quality to higher-concentration contrast while substantially reducing radiation dose.
In 135 patients, higher total iodine dose per kg improved tumor-liver contrast and lesion conspicuity for hypervascular HCC on dynamic CT; doses ≥525 mg I/kg recommended for best depiction.
In 135 patients, higher total iodine dose per kg improved tumor-liver contrast and lesion conspicuity for hypervascular HCC on dynamic CT; doses ≥525 mg I/kg recommended for best depiction.
In 97 patients, tailoring iodine dose to estimated lean body weight produced similar mean aortic enhancement as total body weight dosing but reduced interpatient variability.
130 patients randomized to patient-specific iodine dose (p-COP) vs standard protocol for hepatic CT; p-COP reduced interpatient variability of aortic enhancement and increased the proportion achieving acceptable aortic enhancement without changing hepatic enhancement mean.
In 97 patients, tailoring iodine dose to estimated lean body weight produced similar mean aortic enhancement as total body weight dosing but reduced interpatient variability.
Compared artificial dermis + rb‑FGF versus standard povidone‑iodine gauze for residual infected burn wounds; artificial dermis + rb‑FGF showed better healing and bacterial clearance.
Compared artificial dermis + rb‑FGF versus standard povidone‑iodine gauze for residual infected burn wounds; artificial dermis + rb‑FGF showed better healing and bacterial clearance.
A 12‑week dietary intervention to increase protein meals in older adults raised overall protein and several micronutrient intakes, including iodine, driven by more animal‑derived protein foods.
A 12‑week dietary intervention to increase protein meals in older adults raised overall protein and several micronutrient intakes, including iodine, driven by more animal‑derived protein foods.
Lower tube voltage (80 kVp) increased venous attenuation and allowed reducing iodine contrast dose to 400 mgI/kg while maintaining image quality comparable to standard 600 mgI/kg at 120 kVp.
Lower tube voltage (80 kVp) increased venous attenuation and allowed reducing iodine contrast dose to 400 mgI/kg while maintaining image quality comparable to standard 600 mgI/kg at 120 kVp.
Lower-strength iodine contrast produced diagnostically excellent neck CTs with fewer immediate minor side effects than higher-strength contrast.
Lower-strength iodine contrast produced diagnostically excellent neck CTs with fewer immediate minor side effects than higher-strength contrast.
Derived and tested a formula to predict liver CT enhancement from iodine dose and patient weight; accuracy similar to an existing formula.
Derived and tested a formula to predict liver CT enhancement from iodine dose and patient weight; accuracy similar to an existing formula.
A personalized diluted contrast protocol with a test bolus produced diagnostic craniocervical CTA while significantly reducing radiation dose and iodine uptake.
A personalized diluted contrast protocol with a test bolus produced diagnostic craniocervical CTA while significantly reducing radiation dose and iodine uptake.
In patients with renal insufficiency receiving iodine contrast for emergency CT, IV NAC was associated with fewer creatinine-defined nephrotoxic events but no change by cystatin C.
In patients with renal insufficiency receiving iodine contrast for emergency CT, IV NAC was associated with fewer creatinine-defined nephrotoxic events but no change by cystatin C.
Randomized trial in 40 HSCT patients comparing a supersaturated calcium phosphate rinse to routine oral care (control regimen included povidone‑iodine among other agents); SCPR group had less and shorter mucositis and less mouth pain and TPN use.
Randomized trial in 40 HSCT patients comparing a supersaturated calcium phosphate rinse to routine oral care (control regimen included povidone‑iodine among other agents); SCPR group had less and shorter mucositis and less mouth pain and TPN use.
Randomized trial in 40 HSCT patients comparing a supersaturated calcium phosphate rinse to routine oral care (control regimen included povidone‑iodine among other agents); SCPR group had less and shorter mucositis and less mouth pain and TPN use.
Randomized trial in 70 BPH surgery patients comparing 0.5% povidone‑iodine skin antisepsis to alcohol‑based chlorhexidine; no difference in surgical site infection risk was observed between antiseptics.
Randomized multicenter pilot trial comparing turpentine ointment (verum), placebo, and a comparator disinfectant containing povidone‑iodine in 70 patients with acute folliculitis; primary endpoint differences were not statistically significant for the comparator (povidone‑iodine) vs placebo.
Randomized multicenter pilot trial comparing turpentine ointment (verum), placebo, and a comparator disinfectant containing povidone‑iodine in 70 patients with acute folliculitis; primary endpoint differences were not statistically significant for the comparator (povidone‑iodine) vs placebo.
Eating the iodine- and chromium-enriched Laminaria jam for 6 months led to larger weight loss, lower blood pressure, and better cholesterol than standard therapy.
Eating the iodine- and chromium-enriched Laminaria jam for 6 months led to larger weight loss, lower blood pressure, and better cholesterol than standard therapy.
During angiography, iomeprol caused less heat/pain sensation than iopentol by patient VAS scores.
Nonionic iodine contrast caused less patient motion and improved CT scan quality compared with ionic contrast.
Nonionic iodine contrast caused less patient motion and improved CT scan quality compared with ionic contrast.
In mothers with borderline thyroid function, high maternal perchlorate in early pregnancy was linked to higher odds of low IQ in their children at age 3.
In mothers with borderline thyroid function, high maternal perchlorate in early pregnancy was linked to higher odds of low IQ in their children at age 3.
Two different iodine contrast concentrations produced similar stent image quality on coronary CT; image quality mainly influenced by stent diameter, heart rate variation, and LAI ratio.
Two different iodine contrast concentrations produced similar stent image quality on coronary CT; image quality mainly influenced by stent diameter, heart rate variation, and LAI ratio.
Using lower tube voltage with proportionally lower iodine dose maintained or improved CT image quality while substantially reducing contrast dose and injection rate.
Using lower tube voltage with proportionally lower iodine dose maintained or improved CT image quality while substantially reducing contrast dose and injection rate.
Using lower tube voltage with proportionally lower iodine dose maintained or improved CT image quality while substantially reducing contrast dose and injection rate.
Sentinel lymph node biopsy detected occult lateral metastases but did not change stimulated thyroglobulin after ablation or recurrence rates at median 39-month follow-up.
Low-dose iodide (0.2 mg/day) for 12 months reduced thyroid size in adults with endemic goiter but triggered reversible thyroid autoimmunity/dysfunction in a minority.
Low-dose iodide (0.2 mg/day) for 12 months reduced thyroid size in adults with endemic goiter but triggered reversible thyroid autoimmunity/dysfunction in a minority.
Compared a sequential thyroid defunctionalization preoperative method to conventional antithyroid drugs plus iodine; the test method reduced bleeding and complications.
Pregnant women randomized to eat 400 g cod/week for 16 weeks had slightly higher hair mercury levels overall, but levels remained generally low.
Pregnant women randomized to eat 400 g cod/week for 16 weeks had slightly higher hair mercury levels overall, but levels remained generally low.
Higher iodine dose and faster injection rate of iodinated contrast produced greater pancreatic enhancement (higher HU) on CT.
Randomized trial (MEBO versus standard therapy using povidone iodine plus bepanthenol) in ~211 hospitalized patients with partial-thickness burns: MEBO reduced hospital stay, time to 50% wound healing (superficial burns), and pain/analgesic use compared with the povidone-iodine standard.
Randomized trial (MEBO versus standard therapy using povidone iodine plus bepanthenol) in ~211 hospitalized patients with partial-thickness burns: MEBO reduced hospital stay, time to 50% wound healing (superficial burns), and pain/analgesic use compared with the povidone-iodine standard.
Randomized trial (MEBO versus standard therapy using povidone iodine plus bepanthenol) in ~211 hospitalized patients with partial-thickness burns: MEBO reduced hospital stay, time to 50% wound healing (superficial burns), and pain/analgesic use compared with the povidone-iodine standard.
130 patients randomized to patient-specific iodine dose (p-COP) vs standard protocol for hepatic CT; p-COP reduced interpatient variability of aortic enhancement and increased the proportion achieving acceptable aortic enhancement without changing hepatic enhancement mean.
130 patients randomized to patient-specific iodine dose (p-COP) vs standard protocol for hepatic CT; p-COP reduced interpatient variability of aortic enhancement and increased the proportion achieving acceptable aortic enhancement without changing hepatic enhancement mean.
127 patients randomized to standard vs BMI-based individualized DECT CTPA: individualized protocol substantially reduced radiation and iodine doses (about 34% and ~57% respectively), improved SNR/CNR and reduced superior vena cava artifacts while maintaining or improving diagnostic image quality.
127 patients randomized to standard vs BMI-based individualized DECT CTPA: individualized protocol substantially reduced radiation and iodine doses (about 34% and ~57% respectively), improved SNR/CNR and reduced superior vena cava artifacts while maintaining or improving diagnostic image quality.
Reducing injection rate and contrast dose (iodine-containing agent) in 3D DSA was feasible and produced satisfactory images.
Reducing injection rate and contrast dose (iodine-containing agent) in 3D DSA was feasible and produced satisfactory images.
Using 80 kVp plus iterative reconstruction allowed reduction of iodine contrast dose while maintaining or improving some image metrics and lowering radiation dose.
Timing after iodine contrast threshold (50 H in aorta) of 10–15 s and 45–55 s optimizes arterial and portal venous phases for detecting hypervascular HCCs.
Timing after iodine contrast threshold (50 H in aorta) of 10–15 s and 45–55 s optimizes arterial and portal venous phases for detecting hypervascular HCCs.
Timing after iodine contrast threshold (50 H in aorta) of 10–15 s and 45–55 s optimizes arterial and portal venous phases for detecting hypervascular HCCs.
In patients undergoing abdominal MDCT, shorter (25 s) contrast injection increased early aortic/arterial enhancement while longer (35 s) injection increased liver enhancement; pancreas unchanged.
In patients undergoing abdominal MDCT, shorter (25 s) contrast injection increased early aortic/arterial enhancement while longer (35 s) injection increased liver enhancement; pancreas unchanged.
In patients undergoing abdominal MDCT, shorter (25 s) contrast injection increased early aortic/arterial enhancement while longer (35 s) injection increased liver enhancement; pancreas unchanged.
Observational analysis of diet in women with gestational diabetes found many had inadequate intakes of several nutrients including vitamin D.
In selected patients, 70 kVp CCTA with half the usual contrast volume produced higher vessel attenuation, higher image noise and lower SNR/CNR in some coronary vessels, but achieved substantially lower radiation dose and diagnostic image quality in most cases.
In selected patients, 70 kVp CCTA with half the usual contrast volume produced higher vessel attenuation, higher image noise and lower SNR/CNR in some coronary vessels, but achieved substantially lower radiation dose and diagnostic image quality in most cases.
In selected patients, 70 kVp CCTA with half the usual contrast volume produced higher vessel attenuation, higher image noise and lower SNR/CNR in some coronary vessels, but achieved substantially lower radiation dose and diagnostic image quality in most cases.
In randomized PET/CT protocols, single-phase CT during normal expiration (protocol B) produced the best organ coregistration (least misalignment) and, along with protocol D, the best CT image quality compared with multiphase approaches.
In randomized PET/CT protocols, single-phase CT during normal expiration (protocol B) produced the best organ coregistration (least misalignment) and, along with protocol D, the best CT image quality compared with multiphase approaches.
Large cohort study of brachytherapy for localized prostate cancer; Iodine-125 seed monotherapy produced excellent 5-year biochemical control, and higher delivered dose (D90>140 Gy) was associated with better outcomes.
Large cohort study of brachytherapy for localized prostate cancer; Iodine-125 seed monotherapy produced excellent 5-year biochemical control, and higher delivered dose (D90>140 Gy) was associated with better outcomes.
Using 80 kVp low-iodine contrast protocol with IMR in CABG patients reduced radiation and iodine load and improved image quality for aorta, left ventricle and venous grafts.
Iodixanol 320 provided similar arterial vascular/myocardial enhancement to iohexol 350 but produced greater delayed LV myocardial enhancement.
Iodixanol 320 provided similar arterial vascular/myocardial enhancement to iohexol 350 but produced greater delayed LV myocardial enhancement.
Topical antibiotics combined with 2.5% povidone-iodine (PVI) irrigation substantially reduced conjunctival bacterial carriage immediately prior to cataract surgery.
Topical antibiotics combined with 2.5% povidone-iodine (PVI) irrigation substantially reduced conjunctival bacterial carriage immediately prior to cataract surgery.
Expanded periurethral cleansing with povidone-iodine reduced catheter-associated urinary infections versus usual cleansing in comatose ICU patients.
Expanded periurethral cleansing with povidone-iodine reduced catheter-associated urinary infections versus usual cleansing in comatose ICU patients.
Expanded periurethral cleansing with povidone-iodine reduced catheter-associated urinary infections versus usual cleansing in comatose ICU patients.
In a small randomized subsample, an 8-week whole-food plant-based diet reduced weight, HbA1c and several cardiometabolic risk factors but decreased intake of some micronutrients including vitamin D and calcium.
Rectal washout with povidone-iodine reduced rectal mucosa contamination but did not reduce contamination of the stapler pin or postoperative infection rates.
Rectal washout with povidone-iodine reduced rectal mucosa contamination but did not reduce contamination of the stapler pin or postoperative infection rates.
Rectal washout with povidone-iodine reduced rectal mucosa contamination but did not reduce contamination of the stapler pin or postoperative infection rates.
Iomeprol-400 produced greater arterial and portal venous enhancement on MDCT than iodixanol-320 with similar safety profiles.
Iomeprol-400 produced greater arterial and portal venous enhancement on MDCT than iodixanol-320 with similar safety profiles.
CO2 contrast produced similar procedural outcomes to iodine contrast for EVAR in patients without contraindications to iodine, though many procedures required supplemental iodine contrast.
CO2 contrast produced similar procedural outcomes to iodine contrast for EVAR in patients without contraindications to iodine, though many procedures required supplemental iodine contrast.
CO2 contrast produced similar procedural outcomes to iodine contrast for EVAR in patients without contraindications to iodine, though many procedures required supplemental iodine contrast.
Two long-term dietary patterns affected several serum minerals over 24 months; serum calcium showed no significant change while other minerals (selenium, manganese, magnesium) increased and serum zinc decreased.
Double-blind randomized trial of two iodine-containing contrast agents in cerebral angiography found similar diagnostic efficacy and no significant difference in adverse event rates.
Study of children with minor school injuries comparing topical treatments found the novel gel reduced clinical infections; povidone-iodine was a comparator.
Randomized study in cataract surgery patients found that 3-day preoperative topical antibiotic reduced knife contamination compared with single pre-op dose; all patients also received povidone-iodine perioperatively.
Economic analysis based on a randomized study found iodixanol (isosmolar, iodine-based) was associated with fewer serious adverse reactions (notably acute renal failure) and lower costs than iohexol in high-risk patients.
Economic analysis based on a randomized study found iodixanol (isosmolar, iodine-based) was associated with fewer serious adverse reactions (notably acute renal failure) and lower costs than iohexol in high-risk patients.
Double-blind randomized trial in pregnant women showed that a micronutrient-fortified beverage (including iodine) increased hemoglobin and ferritin and reduced risk of anemia and iron deficiency.
Double-blind randomized trial in pregnant women showed that a micronutrient-fortified beverage (including iodine) increased hemoglobin and ferritin and reduced risk of anemia and iron deficiency.
School lunch seasoning fortified with multiple micronutrients (including 50 μg iodine per serving) reduced respiratory and diarrheal morbidity and slightly improved a visual recall test, but did not change growth.
School lunch seasoning fortified with multiple micronutrients (including 50 μg iodine per serving) reduced respiratory and diarrheal morbidity and slightly improved a visual recall test, but did not change growth.
Study evaluated visual inspection with Lugol's iodine (VILI) and acetic acid (VIA) versus Pap cytology for cervical cancer screening in 1,528 women in Kinshasa.
Study evaluated visual inspection with Lugol's iodine (VILI) and acetic acid (VIA) versus Pap cytology for cervical cancer screening in 1,528 women in Kinshasa.
Study evaluated visual inspection with Lugol's iodine (VILI) and acetic acid (VIA) versus Pap cytology for cervical cancer screening in 1,528 women in Kinshasa.
Four-week randomized diet trial in women showing the Paleolithic diet led to greater short-term weight and fat loss and reduced dietary calcium intake compared to guidelines-based diet.
Individualized dietary counseling in older caregivers increased protein intake, raised calcium intake modestly, and greatly increased use of vitamin D supplementation over 6 months.
Individualized dietary counseling in older caregivers increased protein intake, raised calcium intake modestly, and greatly increased use of vitamin D supplementation over 6 months.
Single-center randomized trial in patients with renal dysfunction receiving iodinated contrast showed N-acetylcysteine (NAC) reduced occurrence of contrast-induced acute kidney injury (CIAKI).
Single-center randomized trial in patients with renal dysfunction receiving iodinated contrast showed N-acetylcysteine (NAC) reduced occurrence of contrast-induced acute kidney injury (CIAKI).
An 8-week intensive lifestyle program in children with abdominal obesity increased diet quality and improved some micronutrient intakes including calcium and vitamin D, and reduced BMI-SDS.
An 8-week intensive lifestyle program in children with abdominal obesity increased diet quality and improved some micronutrient intakes including calcium and vitamin D, and reduced BMI-SDS.
Randomized study in 180 patients (174 analyzed) comparing 24G side-hole vs 22G end-hole catheters for MDCT contrast (iodine) administration found similar safety and contrast enhancement but higher injection pressure with 24G.
Randomized study in 180 patients (174 analyzed) comparing 24G side-hole vs 22G end-hole catheters for MDCT contrast (iodine) administration found similar safety and contrast enhancement but higher injection pressure with 24G.
Randomized study in 180 patients (174 analyzed) comparing 24G side-hole vs 22G end-hole catheters for MDCT contrast (iodine) administration found similar safety and contrast enhancement but higher injection pressure with 24G.
Compared two timing methods for iodinated contrast injection in CT angiography; bolus-tracking gave slightly higher vessel contrast but no significant difference.
Compared two timing methods for iodinated contrast injection in CT angiography; bolus-tracking gave slightly higher vessel contrast but no significant difference.
Compared two timing methods for iodinated contrast injection in CT angiography; bolus-tracking gave slightly higher vessel contrast but no significant difference.
Pregnant women received additional antimicrobial care including topical iodine; their children had lower caries prevalence by age 2.
Pregnant women received additional antimicrobial care including topical iodine; their children had lower caries prevalence by age 2.
Tested different iodinated contrast injection rates for head/neck CT; 2 mL/s provided the longest duration of adequate vessel enhancement.
Tested different iodinated contrast injection rates for head/neck CT; 2 mL/s provided the longest duration of adequate vessel enhancement.
Tested different iodinated contrast injection rates for head/neck CT; 2 mL/s provided the longest duration of adequate vessel enhancement.
Power-Doppler ultrasound showed high thyroid blood flow in Graves' disease and that preoperative Lugol's iodine reduced thyroid parenchymal blood flow.
Power-Doppler ultrasound showed high thyroid blood flow in Graves' disease and that preoperative Lugol's iodine reduced thyroid parenchymal blood flow.
A weight- and concentration-adjusted iodine-dose protocol for CT produced more consistent vessel enhancement and reduced total contrast volume versus a fixed protocol.
A weight- and concentration-adjusted iodine-dose protocol for CT produced more consistent vessel enhancement and reduced total contrast volume versus a fixed protocol.
A weight- and concentration-adjusted iodine-dose protocol for CT produced more consistent vessel enhancement and reduced total contrast volume versus a fixed protocol.
Twice‑RDA multiple micronutrient supplement (including iodine) for six months did not change 12‑month mortality, growth, or CD4 counts versus standard multivitamins.
Twice‑RDA multiple micronutrient supplement (including iodine) for six months did not change 12‑month mortality, growth, or CD4 counts versus standard multivitamins.
Biphasic contrast injection provided better liver and infrarenal IVC enhancement and fewer SVC artifacts than a uniphasic protocol in whole-body CT screening.
Biphasic contrast injection provided better liver and infrarenal IVC enhancement and fewer SVC artifacts than a uniphasic protocol in whole-body CT screening.
Biphasic contrast injection provided better liver and infrarenal IVC enhancement and fewer SVC artifacts than a uniphasic protocol in whole-body CT screening.
In this randomized substudy, antenatal multiple micronutrients (including vitamin D) improved maternal micronutrient biomarkers in late pregnancy but many deficiencies persisted.
In this randomized substudy, antenatal multiple micronutrients (including vitamin D) improved maternal micronutrient biomarkers in late pregnancy but many deficiencies persisted.
In this randomized substudy, antenatal multiple micronutrients (including vitamin D) improved maternal micronutrient biomarkers in late pregnancy but many deficiencies persisted.
Multimicronutrient tablets (which included 5 µg vitamin D) modestly reduced Schistosoma mansoni reinfection intensity but did not affect other helminth reinfections.
Multimicronutrient tablets (which included 5 µg vitamin D) modestly reduced Schistosoma mansoni reinfection intensity but did not affect other helminth reinfections.
Tested four mouthwashes (including povidone-iodine) in hospitalized COVID-19 patients and found no significant overall reduction in salivary viral RNA compared with baseline or control.
Tested four mouthwashes (including povidone-iodine) in hospitalized COVID-19 patients and found no significant overall reduction in salivary viral RNA compared with baseline or control.
Tested four mouthwashes (including povidone-iodine) in hospitalized COVID-19 patients and found no significant overall reduction in salivary viral RNA compared with baseline or control.
In high-risk patients undergoing coronary angiography/PCI, short peri-procedural low-dose tolvaptan plus hydration reduced early cystatin-C–based CI-AKI incidence and renal medullary contrast retention measured by iodine concentration on spectral CT.
In high-risk patients undergoing coronary angiography/PCI, short peri-procedural low-dose tolvaptan plus hydration reduced early cystatin-C–based CI-AKI incidence and renal medullary contrast retention measured by iodine concentration on spectral CT.
In high-risk patients undergoing coronary angiography/PCI, short peri-procedural low-dose tolvaptan plus hydration reduced early cystatin-C–based CI-AKI incidence and renal medullary contrast retention measured by iodine concentration on spectral CT.
Compared three skin-prep solutions; chlorhexidine plus alcohol (ChloraPrep) eliminated bacteria from the forefoot more effectively than povidone-iodine–containing DuraPrep or chloroxylenol.
Compared three skin-prep solutions; chlorhexidine plus alcohol (ChloraPrep) eliminated bacteria from the forefoot more effectively than povidone-iodine–containing DuraPrep or chloroxylenol.
Compared three skin-prep solutions; chlorhexidine plus alcohol (ChloraPrep) eliminated bacteria from the forefoot more effectively than povidone-iodine–containing DuraPrep or chloroxylenol.
In 186 men undergoing testosterone pellet implantation, soaking pellets in gentamicin did not significantly reduce extrusion rates; povidone-iodine skin disinfectant was associated with fewer extrusions than mixed alcohol.
In 186 men undergoing testosterone pellet implantation, soaking pellets in gentamicin did not significantly reduce extrusion rates; povidone-iodine skin disinfectant was associated with fewer extrusions than mixed alcohol.
Iodinated contrast boluses produce short-lived increases in myocardial blood flow and contrast-derived indices can predict adenosine test results, reducing adenosine use.
Iodinated contrast boluses produce short-lived increases in myocardial blood flow and contrast-derived indices can predict adenosine test results, reducing adenosine use.
Iodinated contrast boluses produce short-lived increases in myocardial blood flow and contrast-derived indices can predict adenosine test results, reducing adenosine use.
Remote ischemic preconditioning did not change creatinine overall after iodinated contrast exposure, but in very high-risk patients (Mehran ≥11) it was associated with a smaller rise in creatinine.
Remote ischemic preconditioning did not change creatinine overall after iodinated contrast exposure, but in very high-risk patients (Mehran ≥11) it was associated with a smaller rise in creatinine.
Remote ischemic preconditioning did not change creatinine overall after iodinated contrast exposure, but in very high-risk patients (Mehran ≥11) it was associated with a smaller rise in creatinine.
Dose-dependent nephrotoxic effects of two iodinated contrast agents were quantified; iobitridol showed a steeper load-to-damage slope than iodixanol, and diabetics had much higher slopes.
Dose-dependent nephrotoxic effects of two iodinated contrast agents were quantified; iobitridol showed a steeper load-to-damage slope than iodixanol, and diabetics had much higher slopes.
Dose-dependent nephrotoxic effects of two iodinated contrast agents were quantified; iobitridol showed a steeper load-to-damage slope than iodixanol, and diabetics had much higher slopes.
Iodine-impregnated dressing (Inadine) showed no advantage over non-iodine dressings for ulcer healing at 24 weeks; costs differed between products.
Iodine-impregnated dressing (Inadine) showed no advantage over non-iodine dressings for ulcer healing at 24 weeks; costs differed between products.
Large randomised trial comparing supplemental breast imaging in women with dense breasts; contrast-enhanced mammography (iodinated contrast) and abbreviated MRI detected more cancers than ABUS but iodinated contrast caused allergic/reaction events.
Large randomised trial comparing supplemental breast imaging in women with dense breasts; contrast-enhanced mammography (iodinated contrast) and abbreviated MRI detected more cancers than ABUS but iodinated contrast caused allergic/reaction events.
Large randomised trial comparing supplemental breast imaging in women with dense breasts; contrast-enhanced mammography (iodinated contrast) and abbreviated MRI detected more cancers than ABUS but iodinated contrast caused allergic/reaction events.
In patients receiving iodinated contrast, peri‑procedure hydration with sodium bicarbonate reduced occurrence of contrast‑induced nephropathy compared with sodium chloride.
In patients receiving iodinated contrast, peri‑procedure hydration with sodium bicarbonate reduced occurrence of contrast‑induced nephropathy compared with sodium chloride.
Using spectral CT with a lower‑concentration iodinated contrast reduced total iodine dose by ~28% while achieving equal or better vascular image quality than conventional CTA.
Using spectral CT with a lower‑concentration iodinated contrast reduced total iodine dose by ~28% while achieving equal or better vascular image quality than conventional CTA.
In high-risk toddlers, topical 10% povidone-iodine applied to teeth reduced the development of early childhood caries compared with placebo.
In CKD patients undergoing contrast CT, rates of contrast-induced nephropathy were low and similar between iodixanol-320 and iopamidol-370, with small numeric differences.
In CKD patients undergoing contrast CT, rates of contrast-induced nephropathy were low and similar between iodixanol-320 and iopamidol-370, with small numeric differences.
In CKD patients, intravenous iodixanol-320 was associated with a higher incidence of contrast-induced nephropathy and a greater mean rise in serum creatinine than iomeprol-400.
In CKD patients, intravenous iodixanol-320 was associated with a higher incidence of contrast-induced nephropathy and a greater mean rise in serum creatinine than iomeprol-400.
A one-stop-shop CT protocol reduced the required iodinated contrast volume, scan time, and radiation dose while preserving image quality compared with the traditional separate-protocol approach in suspected acute ischemic stroke patients.
A one-stop-shop CT protocol reduced the required iodinated contrast volume, scan time, and radiation dose while preserving image quality compared with the traditional separate-protocol approach in suspected acute ischemic stroke patients.
A one-stop-shop CT protocol reduced the required iodinated contrast volume, scan time, and radiation dose while preserving image quality compared with the traditional separate-protocol approach in suspected acute ischemic stroke patients.
Phase III RCT comparing R-BEAM vs B-BEAM (with I-131 tositumomab) before autologous transplant; similar 2-year PFS and OS, higher mucositis with radioimmunotherapy arm.
Phase III RCT comparing R-BEAM vs B-BEAM (with I-131 tositumomab) before autologous transplant; similar 2-year PFS and OS, higher mucositis with radioimmunotherapy arm.
Phase III RCT comparing R-BEAM vs B-BEAM (with I-131 tositumomab) before autologous transplant; similar 2-year PFS and OS, higher mucositis with radioimmunotherapy arm.
Randomized study: using higher iodine concentration contrast plus reduced tube current cut radiation dose ~42% while maintaining image quality.
Randomized study: using higher iodine concentration contrast plus reduced tube current cut radiation dose ~42% while maintaining image quality.
Randomized study: using higher iodine concentration contrast plus reduced tube current cut radiation dose ~42% while maintaining image quality.
Small randomized pilot comparing single-fraction HDR vs I-125 LDR brachytherapy: LDR produced lower PSA nadir and more patients reached PSA <0.4 ng/mL; toxicity similar.
Small randomized pilot comparing single-fraction HDR vs I-125 LDR brachytherapy: LDR produced lower PSA nadir and more patients reached PSA <0.4 ng/mL; toxicity similar.
Small randomized pilot comparing single-fraction HDR vs I-125 LDR brachytherapy: LDR produced lower PSA nadir and more patients reached PSA <0.4 ng/mL; toxicity similar.
Large RCT comparing EBRT+BT vs BT alone: addition of EBRT did not improve 5‑year freedom from progression but increased late GU/GI toxicity.
Large RCT comparing EBRT+BT vs BT alone: addition of EBRT did not improve 5‑year freedom from progression but increased late GU/GI toxicity.
Compared ciNPWT versus standard sterile gauze with an iodine disinfectant after ventral hernia repair; ciNPWT reduced infections numerically but increased hospital stay.
Compared ciNPWT versus standard sterile gauze with an iodine disinfectant after ventral hernia repair; ciNPWT reduced infections numerically but increased hospital stay.
In poorly controlled T2D patients, nonsurgical periodontal therapy including subgingival irrigation with 10% povidone-iodine significantly improved periodontal status and reduced HbA1c versus control.
Two double-blind RCTs tested multiple antiseptic rinses including povidone iodine; only the CPC-containing rinse significantly reduced salivary SARS-CoV-2 viral load at 30 min, while povidone iodine did not show a significant effect in these trials.
Cross-sectional study showing long-term environmental cadmium exposure alters urinary mineral balance, including increased urinary calcium.
Large randomized equivalence trial found hand-rubbing with 75% aqueous alcohol was as effective as traditional hand-scrubbing with antiseptic soap containing 4% povidone iodine or 4% chlorhexidine in preventing 30-day surgical site infections, with better tolerance and compliance for hand-rubbing.
Preschool children given fatty fish 3×/week for 16 weeks had higher urinary iodine, higher n‑3 fatty acids, and higher hair mercury than children given meat.
Preschool children given fatty fish 3×/week for 16 weeks had higher urinary iodine, higher n‑3 fatty acids, and higher hair mercury than children given meat.
In patients with stage 3 CKD undergoing iodinated contrast CT, withholding prehydration was noninferior for mean relative creatinine change and had similar low rates of postcontrast AKI.
In patients with stage 3 CKD undergoing iodinated contrast CT, withholding prehydration was noninferior for mean relative creatinine change and had similar low rates of postcontrast AKI.
Phase-3 randomized trial in healthy volunteers comparing two iodinated contrast agents found iohexol-380 increased ascending aorta enhancement but had similar coronary enhancement and similar mild adverse reaction rates.
Phase-3 randomized trial in healthy volunteers comparing two iodinated contrast agents found iohexol-380 increased ascending aorta enhancement but had similar coronary enhancement and similar mild adverse reaction rates.
Randomized double-blind multicenter trial comparing iodixanol (iso-osmolar iodinated contrast) vs iohexol (low-osmolar iodinated contrast) in diabetic patients with impaired renal function; iodixanol produced smaller rises in serum creatinine and fewer clinically significant creatinine increases.
Randomized double-blind multicenter trial comparing iodixanol (iso-osmolar iodinated contrast) vs iohexol (low-osmolar iodinated contrast) in diabetic patients with impaired renal function; iodixanol produced smaller rises in serum creatinine and fewer clinically significant creatinine increases.
Randomized double-blind multicenter trial comparing iodixanol (iso-osmolar iodinated contrast) vs iohexol (low-osmolar iodinated contrast) in diabetic patients with impaired renal function; iodixanol produced smaller rises in serum creatinine and fewer clinically significant creatinine increases.
Randomized trial found that placing an iodine-125 seed-loaded irradiation stent before TACE improved survival and reduced liver failure versus sorafenib+TACE.
Randomized trial found that placing an iodine-125 seed-loaded irradiation stent before TACE improved survival and reduced liver failure versus sorafenib+TACE.
Phase II randomized biomarker study showed that 131I-MIBG therapy alters peripheral radiation biomarkers and that radiosensitizers modify the extent of biomarker changes; some biomarker changes associated with hematologic toxicity.
Phase II randomized biomarker study showed that 131I-MIBG therapy alters peripheral radiation biomarkers and that radiosensitizers modify the extent of biomarker changes; some biomarker changes associated with hematologic toxicity.
Phase II randomized biomarker study showed that 131I-MIBG therapy alters peripheral radiation biomarkers and that radiosensitizers modify the extent of biomarker changes; some biomarker changes associated with hematologic toxicity.
Cross-sectional analysis found that participants with highest metabolic syndrome severity had higher iodine (and sodium) intake compared with those with lowest severity.
Long-term follow-up of SWOG S0016 showed improved 10-year PFS with CHOP plus I-131 tositumomab consolidation but no overall survival benefit; increased MDS/AML incidence with RIT.
Long-term follow-up of SWOG S0016 showed improved 10-year PFS with CHOP plus I-131 tositumomab consolidation but no overall survival benefit; increased MDS/AML incidence with RIT.
Long-term follow-up of SWOG S0016 showed improved 10-year PFS with CHOP plus I-131 tositumomab consolidation but no overall survival benefit; increased MDS/AML incidence with RIT.