Evidence-based effects and studies
Detailed analysis of research findings
A 12-week within-subject controlled clinical trial (one eye treated, the other as control) found the eye cream containing RFF, N-acetylneuraminic acid and peptides increased periorbital hydration, collagen density and skin elasticity with high participant satisfaction and no adverse effects.
Daily intake of a fish-collagen + Djulis drink for 8 weeks produced measurable improvements in multiple skin appearance and hydration measures versus placebo.
A 90-day randomized trial found that ortho-silicic acid stabilized by hydrolyzed marine collagen improved skin firmness, hydration, and texture by clinical assessment.
Adults took caviar extract, a caviar+collagen combo, or placebo for 8 weeks; treatment groups showed improved skin moisture, elasticity, whitening and reduced wrinkles with no serious adverse events.
Randomized placebo‑controlled 12‑week trial in 72 women: daily drinkable collagen peptides + dermonutrients improved objective measures of skin appearance versus placebo.
12-week randomized double-blind placebo-controlled study found 1650 mg/day of collagen peptide (CPNS) improved skin desquamation, hydration, wrinkling, and elasticity in women with no reported side effects.
Randomized double-blind placebo-controlled 12-week trial of an oral plant-derived 'collagen alternative' (VC-H1) showing improvements in skin hydration, barrier function, and elasticity.
Oral low-molecular-weight collagen peptide (1 g/day) for 12 weeks improved skin hydration, reduced wrinkles, and increased elasticity in middle-aged women.
Randomized double-blind placebo-controlled 12-week trial of an oral plant-derived 'collagen alternative' (VC-H1) showing improvements in skin hydration, barrier function, and elasticity.
In older inpatients, daily oral supplement with 10 g collagen peptides for 8 weeks increased forearm skin hydration and elasticity versus control.
Daily 5 g collagen peptides enriched in Hyp‑containing motifs for 42 days increased skin elasticity versus normal collagen hydrolysate and showed higher small‑peptide fraction and cellular uptake in digestion/transport models.
Randomized placebo‑controlled 12‑week trial in 72 women: daily drinkable collagen peptides + dermonutrients improved objective measures of skin appearance versus placebo.
Randomized placebo‑controlled 12‑week trial in 72 women: daily drinkable collagen peptides + dermonutrients improved objective measures of skin appearance versus placebo.
Monthly oral ibandronate increased lumbar spine and hip BMD and reduced bone turnover markers in postmenopausal women on glucocorticoids; vitamin D and calcium were provided to all.
Randomized double-blind placebo-controlled trial of collagen peptide supplement in postmenopausal women; calcium and vitamin D intake were recommended but not controlled; collagen peptides increased BMD and bone formation markers.
Once-weekly alendronate significantly increased bone mineral density and reduced bone turnover markers versus calcium alone over one year.
Alendronate prevented glucocorticoid-induced bone loss, increasing BMD at spine and hip sites over 24 weeks compared with calcium alone.
Ibandronate and alendronate both increased BMD over 1 year; all women also received daily calcium and vitamin D 200 IU.
Long-term alfacalcidol (vitamin D analog) increased bone mineral density at spine and hip and lowered parathyroid hormone and bone turnover markers in pre-dialysis CRF patients.
In Chinese postmenopausal women, daily fortified milk (1200 mg calcium + vitamin D + FOS-inulin) for 52 weeks increased 25(OH)D, suppressed bone turnover markers and preserved femoral neck BMD compared with regular milk.
Randomized double-blind placebo-controlled trial of collagen peptide supplement in postmenopausal women; calcium and vitamin D intake were recommended but not controlled; collagen peptides increased BMD and bone formation markers.
Oral alendronate and yearly zoledronic acid similarly increased bone density and strongly reduced bone resorption biomarkers in adults with osteogenesis imperfecta.
Randomized double-blind trial in thalassemia patients: weekly alendronate for 12 months increased lumbar (L1–L4) BMD and reduced bone turnover markers versus placebo.
Intermittent senolytic therapy did not reduce overall bone resorption but transiently increased a bone formation marker and showed benefit in a high-senescent-burden subgroup.
Randomized double-blind placebo-controlled trial of collagen peptide supplement in postmenopausal women; calcium and vitamin D intake were recommended but not controlled; collagen peptides increased BMD and bone formation markers.
In elderly sedentary men, recreational football increased proximal femur BMD and markers of bone formation and turnover over 12 months.
Pyridoxamine tended to raise a bone formation marker, increased femoral neck BMD, and slightly lowered HbA1c in older women with T2D.
16‑week randomized double‑blind trial (90 enrolled, 87 completed) in women: 5 g/day collagen (± HA + vit C) increased dermal density and reduced roughness and wrinkle severity versus placebo.
16‑week randomized double‑blind trial (90 enrolled, 87 completed) in women: 5 g/day collagen (± HA + vit C) increased dermal density and reduced roughness and wrinkle severity versus placebo.
16‑week randomized double‑blind trial (90 enrolled, 87 completed) in women: 5 g/day collagen (± HA + vit C) increased dermal density and reduced roughness and wrinkle severity versus placebo.
8‑week double‑blind placebo‑controlled study in 114 women showing specific bioactive collagen peptides (2.5 g/day) reduced eye wrinkle volume and increased dermal procollagen I and elastin.
8‑week double‑blind placebo‑controlled study in 114 women showing specific bioactive collagen peptides (2.5 g/day) reduced eye wrinkle volume and increased dermal procollagen I and elastin.
8‑week double‑blind placebo‑controlled study in 114 women showing specific bioactive collagen peptides (2.5 g/day) reduced eye wrinkle volume and increased dermal procollagen I and elastin.
Both microneedling and fractional CO2 laser improved scar clinical scores and histochemical collagen/elastin; fractional CO2 laser produced larger increases in collagen (neocollagenesis).
Randomized double‑blind placebo‑controlled study in middle‑aged active adults (86 randomized, 75 completed) testing 0/10/20 g/day collagen peptides showing dose‑ and time‑dependent improvements in function, pain, and mental/physical QoL in subgroups.
Randomized double‑blind placebo‑controlled study in middle‑aged active adults (86 randomized, 75 completed) testing 0/10/20 g/day collagen peptides showing dose‑ and time‑dependent improvements in function, pain, and mental/physical QoL in subgroups.
Randomized double‑blind placebo‑controlled study in middle‑aged active adults (86 randomized, 75 completed) testing 0/10/20 g/day collagen peptides showing dose‑ and time‑dependent improvements in function, pain, and mental/physical QoL in subgroups.
12‑week randomized triple‑blind placebo‑controlled study (50 randomized, 45 completed) in women showing fish‑derived hydrolyzed collagen (10 g/day) reduced nasolabial wrinkle scores and improved self‑reported skin parameters; elasticity improved in younger subgroup.
12‑week randomized triple‑blind placebo‑controlled study (50 randomized, 45 completed) in women showing fish‑derived hydrolyzed collagen (10 g/day) reduced nasolabial wrinkle scores and improved self‑reported skin parameters; elasticity improved in younger subgroup.
12‑week randomized triple‑blind placebo‑controlled study (50 randomized, 45 completed) in women showing fish‑derived hydrolyzed collagen (10 g/day) reduced nasolabial wrinkle scores and improved self‑reported skin parameters; elasticity improved in younger subgroup.
Randomized double-blind placebo-controlled trial found that 12 weeks of low-molecular-weight collagen peptide supplementation improved wrinkles, skin roughness, elasticity, hydration, and barrier function.
Randomized double-blind placebo-controlled trial found that 12 weeks of low-molecular-weight collagen peptide supplementation improved wrinkles, skin roughness, elasticity, hydration, and barrier function.
Randomized double-blind placebo-controlled trial found that 12 weeks of low-molecular-weight collagen peptide supplementation improved wrinkles, skin roughness, elasticity, hydration, and barrier function.
12-week randomized double-blind placebo-controlled study showing low-molecular-weight collagen peptides improved skin roughness, elasticity, hydration, and skin whitening measures without adverse events.
12-week randomized double-blind placebo-controlled study showing low-molecular-weight collagen peptides improved skin roughness, elasticity, hydration, and skin whitening measures without adverse events.
12-week randomized double-blind placebo-controlled study showing low-molecular-weight collagen peptides improved skin roughness, elasticity, hydration, and skin whitening measures without adverse events.
Adults took caviar extract, a caviar+collagen combo, or placebo for 8 weeks; treatment groups showed improved skin moisture, elasticity, whitening and reduced wrinkles with no serious adverse events.
A 12-week oral chicken sternal cartilage (BioCell Collagen) supplement increased skin collagen and elasticity and reduced wrinkle severity versus placebo.
Daily oral nutricosmeceutical (collagen peptides + antioxidants) for 90 days improved skin elasticity and texture versus placebo.
In 30 women, combined acupotomy subcision plus hyaluronic acid produced greater increases in skin collagen and elasticity and greater wrinkle improvement than either treatment alone.
Adding topical PRP to fractional laser improved patient satisfaction, increased skin elasticity, collagen amount, and fibroblast number on biopsy compared with laser alone.
Topical meristem-cell-based serums applied for 4 weeks improved skin hydration, elasticity and increased dermal collagen markers (hydroxyproline) with reduced lipid peroxidation.
90-day randomized placebo-controlled trial of a multi-ingredient nutraceutical containing hydrolyzed fish collagen plus other actives showed large improvements in skin elasticity and joint symptoms.
Daily collagen hydrolysate (2.5 or 5 g) for 8 weeks improved skin elasticity versus placebo in middle-aged women; other skin parameters showed nonsignificant trends.
Multicenter randomized trial comparing standard skin grafts vs grafts plus cultured autologous epidermal cells seeded in a collagen carrier; assessed healing and scar quality.
90-day randomized placebo-controlled trial of a multi-ingredient nutraceutical containing hydrolyzed fish collagen plus other actives showed large improvements in skin elasticity and joint symptoms.
90-day randomized placebo-controlled trial of a multi-ingredient nutraceutical containing hydrolyzed fish collagen plus other actives showed large improvements in skin elasticity and joint symptoms.
12-week triple-blind randomized placebo-controlled trial in women showed that a drinkable supplement containing collagen peptides and dermonutrients improved dermal collagen structure and subjective skin measures without adverse events.
12-week triple-blind randomized placebo-controlled trial in women showed that a drinkable supplement containing collagen peptides and dermonutrients improved dermal collagen structure and subjective skin measures without adverse events.
12-week randomized double-blind placebo-controlled study found 1650 mg/day of collagen peptide (CPNS) improved skin desquamation, hydration, wrinkling, and elasticity in women with no reported side effects.
12-week randomized double-blind placebo-controlled study found 1650 mg/day of collagen peptide (CPNS) improved skin desquamation, hydration, wrinkling, and elasticity in women with no reported side effects.
Daily 5 g collagen peptides for up to 84 days improved dermal density and skin moisture versus placebo and produced earlier improvements in elasticity, wrinkle visibility, nail color, and beauty perception.
In vivo dermatological evaluation of topical formulations containing lyophilized hydrolyzed blue shark cartilage (collagen) applied to inner wrists of volunteers with skin measurements at baseline, 10 min and 20 min.
Daily collagen hydrolysate (2.5 or 5 g) for 8 weeks improved skin elasticity versus placebo in middle-aged women; other skin parameters showed nonsignificant trends.
Daily collagen hydrolysate (2.5 or 5 g) for 8 weeks improved skin elasticity versus placebo in middle-aged women; other skin parameters showed nonsignificant trends.
In recreational athletes, 30 g collagen protein taken after resistance exercise increased circulating glycine/proline but did not increase myofibrillar or muscle connective protein synthesis versus placebo over 5 h.
In recreational athletes, 30 g collagen protein taken after resistance exercise increased circulating glycine/proline but did not increase myofibrillar or muscle connective protein synthesis versus placebo over 5 h.
Fifteen grams hydrolyzed collagen twice daily during 1 week of intense resistance training raised some plasma collagen-related amino acids but did not increase muscle myofibrillar or connective protein synthesis rates.
In recreational athletes, 30 g collagen protein taken after resistance exercise increased circulating glycine/proline but did not increase myofibrillar or muscle connective protein synthesis versus placebo over 5 h.
Daily 2.5 g bioactive collagen peptides for 6 months reduced cellulite severity and improved skin waviness and dermal density, with stronger effects in normal-weight women.
Daily 5 g collagen peptides for up to 84 days improved dermal density and skin moisture versus placebo and produced earlier improvements in elasticity, wrinkle visibility, nail color, and beauty perception.
Daily syrup containing fish collagen (4 g) plus CoQ10 for 12 weeks increased dermis density and reduced periorbital wrinkles and overall wrinkle score vs placebo.
Daily 5 g collagen peptides for up to 84 days improved dermal density and skin moisture versus placebo and produced earlier improvements in elasticity, wrinkle visibility, nail color, and beauty perception.
Daily 2.5 g bioactive collagen peptides for 6 months reduced cellulite severity and improved skin waviness and dermal density, with stronger effects in normal-weight women.
Daily 2.5 g bioactive collagen peptides for 6 months reduced cellulite severity and improved skin waviness and dermal density, with stronger effects in normal-weight women.
Randomized double-blind placebo-controlled trial: 5 g/day specific collagen peptides for 12 weeks reduced activity-related knee pain versus placebo in physically active young adults.
Daily 5 g bioactive collagen peptides for 12 weeks in athletic adults reduced activity-related knee pain versus placebo (significant VAS improvement) and reduced use of additional therapies.
Daily 5 g bioactive collagen peptides for 12 weeks in athletic adults reduced activity-related knee pain versus placebo (significant VAS improvement) and reduced use of additional therapies.
Daily 5 g bioactive collagen peptides for 12 weeks in athletic adults reduced activity-related knee pain versus placebo (significant VAS improvement) and reduced use of additional therapies.
Daily 500 mg hydrolyzed fish cartilage for 90 days improved dermis echogenicity and thickness and reduced facial wrinkles and pore measures versus placebo in middle-aged women.
Adults took caviar extract, a caviar+collagen combo, or placebo for 8 weeks; treatment groups showed improved skin moisture, elasticity, whitening and reduced wrinkles with no serious adverse events.
Daily 500 mg hydrolyzed fish cartilage for 90 days improved dermis echogenicity and thickness and reduced facial wrinkles and pore measures versus placebo in middle-aged women.
Randomised double-blind study comparing porcine/bovine collagen fillers and hyaluronic acid for upper lip wrinkles; all treatments increased lip volume and reduced wrinkles, Perlane showed greatest and most sustained volume.
Split-face trial in which hyaluronic acid fillers improved nasolabial/crow's-feet wrinkles and showed increased local collagen synthesis and good tolerability up to 180 days.
Daily 500 mg hydrolyzed fish cartilage for 90 days improved dermis echogenicity and thickness and reduced facial wrinkles and pore measures versus placebo in middle-aged women.
Adding type‑1 collagen particles plus i‑PRF to periapical surgery did not improve bone‑defect healing compared with surgery alone; both groups showed large lesion reductions at 12 months.
Adding type‑1 collagen particles plus i‑PRF to periapical surgery did not improve bone‑defect healing compared with surgery alone; both groups showed large lesion reductions at 12 months.
Adding type‑1 collagen particles plus i‑PRF to periapical surgery did not improve bone‑defect healing compared with surgery alone; both groups showed large lesion reductions at 12 months.
Porcine collagen matrix (CM) and free gingival graft (FGG) produced comparable 3D tissue thickness changes, but FGG yielded larger gains in keratinized tissue width; CM had less analgesic use and shorter surgical time.
Porcine collagen matrix (CM) and free gingival graft (FGG) produced comparable 3D tissue thickness changes, but FGG yielded larger gains in keratinized tissue width; CM had less analgesic use and shorter surgical time.
Porcine collagen matrix (CM) and free gingival graft (FGG) produced comparable 3D tissue thickness changes, but FGG yielded larger gains in keratinized tissue width; CM had less analgesic use and shorter surgical time.
Collagen matrix (VCMX) produced similar buccal volume gains and better patient‑reported outcomes (less pain) but failed to demonstrate non‑inferiority to connective tissue graft (SCTG) for crestal mucosal thickness at the primary endpoint.
Collagen matrix (VCMX) produced similar buccal volume gains and better patient‑reported outcomes (less pain) but failed to demonstrate non‑inferiority to connective tissue graft (SCTG) for crestal mucosal thickness at the primary endpoint.
Collagen matrix (VCMX) produced similar buccal volume gains and better patient‑reported outcomes (less pain) but failed to demonstrate non‑inferiority to connective tissue graft (SCTG) for crestal mucosal thickness at the primary endpoint.
Use of a collagen membrane with bovine bone graft improved periodontal pocket depth and attachment over 12 months compared with flap procedure alone.
Both access flap alone and access flap with xenograft plus collagen membrane produced similar clinical improvements at 12 months; no significant advantage from adding GBR/collagen membrane.
L-PRF+IBB was non-inferior to collagen membrane+IBB for clinical attachment gain and produced less gingival recession, though it had slightly less probing-depth reduction.
In periodontal defects, GTR using collagen membranes and autogenous periosteal+bone chip treatment both improved probing depth, attachment level, and bone defect fill more than debridement alone; autogenous periosteal approach gave greatest bone gain.
Both access flap alone and access flap with xenograft plus collagen membrane produced similar clinical improvements at 12 months; no significant advantage from adding GBR/collagen membrane.
Both access flap alone and access flap with xenograft plus collagen membrane produced similar clinical improvements at 12 months; no significant advantage from adding GBR/collagen membrane.
Daily 5 g collagen peptides enriched in Hyp‑containing motifs for 42 days increased skin elasticity versus normal collagen hydrolysate and showed higher small‑peptide fraction and cellular uptake in digestion/transport models.
Daily 5 g collagen peptides enriched in Hyp‑containing motifs for 42 days increased skin elasticity versus normal collagen hydrolysate and showed higher small‑peptide fraction and cellular uptake in digestion/transport models.
Daily low‑molecular‑weight collagen peptide (1,650 mg/day) for 8 weeks improved wrinkles, skin elasticity, hydration, dermal density, pore metrics and reduced sebum versus placebo, with sustained effects after washout and no adverse events.
Daily low‑molecular‑weight collagen peptide (1,650 mg/day) for 8 weeks improved wrinkles, skin elasticity, hydration, dermal density, pore metrics and reduced sebum versus placebo, with sustained effects after washout and no adverse events.
A 12-week within-subject controlled clinical trial (one eye treated, the other as control) found the eye cream containing RFF, N-acetylneuraminic acid and peptides increased periorbital hydration, collagen density and skin elasticity with high participant satisfaction and no adverse effects.
Daily low‑molecular‑weight collagen peptide (1,650 mg/day) for 8 weeks improved wrinkles, skin elasticity, hydration, dermal density, pore metrics and reduced sebum versus placebo, with sustained effects after washout and no adverse events.
Daily 5 g specific collagen peptides during 14 weeks of high-load resistance training increased patellar tendon cross-sectional area (hypertrophy) versus placebo; tendon stiffness, muscle CSA and strength improved with training but were not affected by supplementation.
Daily intake of a fish-collagen + Djulis drink for 8 weeks produced measurable improvements in multiple skin appearance and hydration measures versus placebo.
Daily intake of a fish-collagen + Djulis drink for 8 weeks produced measurable improvements in multiple skin appearance and hydration measures versus placebo.
A 90-day randomized trial found that ortho-silicic acid stabilized by hydrolyzed marine collagen improved skin firmness, hydration, and texture by clinical assessment.
Daily intake of a fish-collagen + Djulis drink for 8 weeks produced measurable improvements in multiple skin appearance and hydration measures versus placebo.
Daily intake of a fish-collagen + Djulis drink for 8 weeks produced measurable improvements in multiple skin appearance and hydration measures versus placebo.
In patients with long-standing facial palsy, adding in-situ collagen injections to rehabilitative therapy improved some electromyographic measures and patient-reported disease perception versus rehab alone.
In patients with long-standing facial palsy, adding in-situ collagen injections to rehabilitative therapy improved some electromyographic measures and patient-reported disease perception versus rehab alone.
In patients with long-standing facial palsy, adding in-situ collagen injections to rehabilitative therapy improved some electromyographic measures and patient-reported disease perception versus rehab alone.
Twelve weeks of low-dose oral bovine type II collagen did not produce a statistically significant improvement in early rheumatoid arthritis vs placebo, though numerically more responders occurred in collagen groups.
Daily 5 g specific collagen peptides during 14 weeks of high-load resistance training increased patellar tendon cross-sectional area (hypertrophy) versus placebo; tendon stiffness, muscle CSA and strength improved with training but were not affected by supplementation.
In older adults, 12 months heavy resistance training increased patellar tendon stiffness and preserved material properties compared with moderate/no training; tendon cross-sectional area increased with both training loads, but collagen content and cross-links did not change.
Daily 5 g specific collagen peptides during 14 weeks of high-load resistance training increased patellar tendon cross-sectional area (hypertrophy) versus placebo; tendon stiffness, muscle CSA and strength improved with training but were not affected by supplementation.
Topical fish collagen gel applied to periwound skin (12 weeks) produced higher healing rates, larger quality-of-life gains, and slightly greater pain reduction than placebo, though many between-group differences were not statistically significant.
Multicenter randomized trial comparing a living skin-equivalent (Graftskin, a collagen-containing product) versus moist gauze for chronic diabetic foot ulcers; assessed healing at 12 weeks.
Topical fish collagen gel applied to periwound skin (12 weeks) produced higher healing rates, larger quality-of-life gains, and slightly greater pain reduction than placebo, though many between-group differences were not statistically significant.
Collagen injections (alone or with PRP) and PRP alone all improved pain and function over time, with no clear advantage of collagen over PRP or combined therapy at 24 weeks.
Topical fish collagen gel applied to periwound skin (12 weeks) produced higher healing rates, larger quality-of-life gains, and slightly greater pain reduction than placebo, though many between-group differences were not statistically significant.
Combined UC-II and hydrolysed collagen (daily) for 12 weeks produced improvements in pain and function similar to placebo; no significant between-group differences were observed.
Combined UC-II and hydrolysed collagen (daily) for 12 weeks produced improvements in pain and function similar to placebo; no significant between-group differences were observed.
Combined UC-II and hydrolysed collagen (daily) for 12 weeks produced improvements in pain and function similar to placebo; no significant between-group differences were observed.
Stentoplasty using resorbable calcium-salt bone fillers in older adults with a single vertebral compression fracture reduced pain and disability and promoted bone formation over 3 years, with slight early loss of restored vertebral height.
In athletes with early knee arthritis, 12 weeks of collagen supplementation reduced pain from baseline but was not superior to exercise; combined collagen+exercise improved several functional outcomes.
A 6-month randomized trial found the product containing undenatured type II collagen (Artneo) improved pain, stiffness, and some MRI signs of synovitis and was not inferior to glucosamine+chondroitin.
Adding leukocyte- and platelet-rich fibrin (with or without occlusive membrane including collagen membrane stratum) to root-end surgery did not improve patient-reported pain, symptoms, activity impairment, or medication use in the first postoperative week.
Randomized, double-blind 24-week pilot trial in knee OA patients comparing HC-II (type II collagen hydrolysate), EC-HC-II (chicken essence + HC-II), glucosamine, and placebo; HC-II reduced early pain and EC-HC-II increased fat-free mass and grip strength versus some comparators.
A single intra-articular injection of type I atelocollagen reduced knee pain (VAS) more than saline at 24 weeks; functional scores (WOMAC, SF-36) improved from baseline but differences versus placebo were not significant.
Multicenter double-blind randomized trial (stage III knee OA subgroup) showing undenatured type II chicken collagen (NK2/Artneo) improved pain, stiffness, function and quality of life vs placebo over 180 days.
Intra-articular porcine-collagen product (MD-Knee) was non-inferior to sodium hyaluronate in improving function and pain in knee osteoarthritis up to 6 months.
Adding native/hydrolyzed collagen to a combo of CS/GL/MSM/HA produced larger pain reductions and better function than the same regimen without collagen in knee OA exacerbations.
Oral chicken type II collagen (0.1 mg/day) reduced pain, stiffness and joint counts in RA patients but was less effective than methotrexate and had fewer/milder side effects.
Randomized double-blind 30-day trial (67 completers) found Aflapin reduced knee pain and improved function; collagen type II cleavage biomarker (C2C) and inflammatory biomarkers decreased.
Adding i-PRF to autogenous demineralized dentin graft did not change alveolar ridge width loss but reduced patient-reported pain and better preserved keratinized tissue at 6 months.
A single intra-articular injection of type I atelocollagen reduced knee pain (VAS) more than saline at 24 weeks; functional scores (WOMAC, SF-36) improved from baseline but differences versus placebo were not significant.
Adding rhPDGF to a porcine cross-linked collagen matrix improved root coverage, gingival thickness and aesthetic scores at 6 months versus collagen matrix with saline.
Adding cross-linked hyaluronic acid to connective tissue grafts did not change root coverage but increased elastic fibers and produced a modest (non-significant) increase in collagen density.
In older women, collagen peptide supplementation (30 g twice daily for 6 days) did not increase longer-term muscle protein synthesis (MPS), whereas whey protein did; collagen produced only a small acute MPS increase with exercise.
In older women, collagen peptide supplementation (30 g twice daily for 6 days) did not increase longer-term muscle protein synthesis (MPS), whereas whey protein did; collagen produced only a small acute MPS increase with exercise.
Compared connective tissue graft (CTG) versus a collagen matrix (CMX) at single implant sites; CTG produced greater long-term buccal soft tissue gain and less bone loss.
At 1 year CTG produced greater buccal soft tissue increase and less graft shrinkage and marginal bone loss than collagen matrix (CMX).
At 3 months CTG produced numerically larger buccal soft tissue gains than CMX with some measures of worse peri-implant bone and recession for CMX.
At 1 year CTG produced greater buccal soft tissue increase and less graft shrinkage and marginal bone loss than collagen matrix (CMX).
Compared connective tissue graft (CTG) versus a collagen matrix (CMX) at single implant sites; CTG produced greater long-term buccal soft tissue gain and less bone loss.
Randomized study of immediate molar implants using autologous bone chips, a collagen membrane (Ossix), or both; after 12 months all groups had similar modest marginal bone loss.
At 3 months CTG produced numerically larger buccal soft tissue gains than CMX with some measures of worse peri-implant bone and recession for CMX.
At 12 months both transcrestal and lateral sinus floor elevation (latter with a resorbable collagen membrane) achieved near-complete radiographic implant embedding and minimal marginal bone loss.
Compared connective tissue graft (CTG) versus a collagen matrix (CMX) at single implant sites; CTG produced greater long-term buccal soft tissue gain and less bone loss.
Tested Bio-Oss Collagen versus no grafting during sinus floor elevation; after 1 year there were no differences in implant survival, bone loss or patient-reported outcomes.
22 patients received vertical bone augmentation with either resorbable collagen barriers or nonresorbable barriers; both showed minimal and similar bone loss at 3 years.
Tested Bio-Oss Collagen versus no grafting during sinus floor elevation; after 1 year there were no differences in implant survival, bone loss or patient-reported outcomes.
Tested Bio-Oss Collagen versus no grafting during sinus floor elevation; after 1 year there were no differences in implant survival, bone loss or patient-reported outcomes.
Compared topical collagen dressings to hydrocolloid for pressure ulcers over 8 weeks and found similar healing rates and times; collagen was more expensive.
Compared topical collagen dressings to hydrocolloid for pressure ulcers over 8 weeks and found similar healing rates and times; collagen was more expensive.
Randomized trial in chronic diabetic foot ulcers: a porcine-derived purified reconstituted bilayer matrix (ECM product) produced higher 12-week healing rates, faster healing, and much greater wound area reduction than standard collagen-alginate dressing.
Compared topical collagen dressings to hydrocolloid for pressure ulcers over 8 weeks and found similar healing rates and times; collagen was more expensive.
Compared subepithelial connective tissue graft (SCTG) to xenogeneic collagen matrix (XCM) for buccal soft tissue augmentation; SCTG yielded greater thickness gain while XCM reduced operation time.
Using a resorbable collagen membrane did not reduce horizontal bone resorption; piezosurgery showed no clinical advantage over rotative instruments and took longer.
Compared subepithelial connective tissue graft (SCTG) to xenogeneic collagen matrix (XCM) for buccal soft tissue augmentation; SCTG yielded greater thickness gain while XCM reduced operation time.
Compared subepithelial connective tissue graft (SCTG) to xenogeneic collagen matrix (XCM) for buccal soft tissue augmentation; SCTG yielded greater thickness gain while XCM reduced operation time.
Adding porcine atelocollagen patch during rotator cuff repair lowered retear rates at 1 year but did not change shoulder function scores.
Adding porcine atelocollagen patch during rotator cuff repair lowered retear rates at 1 year but did not change shoulder function scores.
At 1 year CTG produced greater buccal soft tissue increase and less graft shrinkage and marginal bone loss than collagen matrix (CMX).
At 3 months CTG produced numerically larger buccal soft tissue gains than CMX with some measures of worse peri-implant bone and recession for CMX.
Porcine collagen matrix used with a tunnel technique reduced surgery time and morbidity but provided less complete root coverage than palatal connective tissue grafts; both improved gingival measures at 12 months.
Using a collagen matrix or enamel matrix with flap surgery improved gum root coverage and gingival thickness compared with flap alone.
Porcine-derived collagen matrix (PDCM) produced better root coverage and less pain/time than connective tissue grafts in smokers.
Adding rhPDGF to a porcine cross-linked collagen matrix improved root coverage, gingival thickness and aesthetic scores at 6 months versus collagen matrix with saline.
Adding rhPDGF to a porcine cross-linked collagen matrix improved root coverage, gingival thickness and aesthetic scores at 6 months versus collagen matrix with saline.
In a split-mouth RCT, xenogeneic collagen matrix (XCM) improved root coverage and quality of life but CTG produced greater final gingival thickness and slightly better root-coverage metrics at 18 months.
Daily oral collagen oligopeptides for 84 days increased dermal ECM gene expression in vitro and was tested in a double-blind randomized trial in women; clinical hydration changes did not reach significance.
Daily oral collagen oligopeptides for 84 days increased dermal ECM gene expression in vitro and was tested in a double-blind randomized trial in women; clinical hydration changes did not reach significance.
Daily oral collagen oligopeptides for 84 days increased dermal ECM gene expression in vitro and was tested in a double-blind randomized trial in women; clinical hydration changes did not reach significance.
Periapical surgery with or without a resorbable collagen membrane produced substantial lesion size reduction at 12 months with no significant difference between groups.
Periapical surgery with or without a resorbable collagen membrane produced substantial lesion size reduction at 12 months with no significant difference between groups.
Periapical surgery with or without a resorbable collagen membrane produced substantial lesion size reduction at 12 months with no significant difference between groups.
Porcine type I collagen dressing for diabetic foot ulcers increased complete healing rate and accelerated wound healing versus foam dressing alone.
Porcine type I collagen dressing for diabetic foot ulcers increased complete healing rate and accelerated wound healing versus foam dressing alone.
Porcine type I collagen dressing for diabetic foot ulcers increased complete healing rate and accelerated wound healing versus foam dressing alone.
Multicenter randomized trial found collagen injections less effective than surgery for cure at 12 months but with fewer and less severe complications and similar quality-of-life.
Multicenter randomized trial found collagen injections less effective than surgery for cure at 12 months but with fewer and less severe complications and similar quality-of-life.
Multicenter randomized trial found collagen injections less effective than surgery for cure at 12 months but with fewer and less severe complications and similar quality-of-life.
Randomized multicenter interim study comparing two collagen membranes for guided bone regeneration found the new membrane non-inferior to reference, with similar safety and a trend to greater bone gain and lower exposure rate.
Randomized multicenter interim study comparing two collagen membranes for guided bone regeneration found the new membrane non-inferior to reference, with similar safety and a trend to greater bone gain and lower exposure rate.
Randomized multicenter interim study comparing two collagen membranes for guided bone regeneration found the new membrane non-inferior to reference, with similar safety and a trend to greater bone gain and lower exposure rate.
Sealing extraction sockets with a porcine collagen matrix gave similar 1-year implant and bone outcomes as connective tissue graft, avoiding a donor site.
Pilot RCT (27 patients) comparing PRF membranes versus standard DBBM plus resorbable collagen membrane for augmented sites; implant survival similar and PRF group had a slightly better peri-implant marginal bone level at 2-year follow-up.
Both guided bone regeneration approaches produced sufficient horizontal ridge augmentation for implants; mean horizontal bone width gains at 18 months were similar and implant survival was 100% in both groups.
Use of a collagen membrane (Bio-Gide) in ridge augmentation did not meaningfully change marginal gingiva or marginal bone levels or implant survival during the first year.
Large cohort study showing that lower serum procollagen type I C-terminal propeptide (PICP) is associated with greater left ventricular reverse remodeling and better heart-failure outcomes.
Large cohort study showing that lower serum procollagen type I C-terminal propeptide (PICP) is associated with greater left ventricular reverse remodeling and better heart-failure outcomes.
Collagen hemostatic sponge reduced postoperative bleeding, transfusions, and hospital stay versus gelatin sponge; topical TXA reduced bleeding more than collagen.
Randomized trial in post-thyroidectomy bleeding showed the oxidised regenerated cellulose–collagen hemostatic agent is non-inferior to carrier-bound fibrin sealant for hemostasis and had no safety concerns.
Randomized trial in post-thyroidectomy bleeding showed the oxidised regenerated cellulose–collagen hemostatic agent is non-inferior to carrier-bound fibrin sealant for hemostasis and had no safety concerns.
Adding a collagen membrane plus bone mineral resulted in more radiographic bone fill but no differences in clinical signs or patient-reported outcomes at 12 months.
Within-subject randomized trial in children found single-application bovine collagen dressings were safe and as effective as human amniotic membrane for superficial partial-thickness burns (healing time and scarring similar).
Randomized multicenter study in patients with diabetic foot: adding Collost (collagen biomaterial) to standard therapy improved ulcer healing over 4 weeks.
A protease-modulating collagen-containing dressing led to more frequent and faster healing of neuropathic diabetic foot ulcers versus standard care over 6 weeks.
Within-subject randomized trial in children found single-application bovine collagen dressings were safe and as effective as human amniotic membrane for superficial partial-thickness burns (healing time and scarring similar).
EpiFix (dehydrated amnion/chorion containing collagen and growth factors) produced faster and higher rates of complete healing and lower product costs than Apligraf or standard care in diabetic foot ulcers.
PACK-CXL added to antimicrobials did not shorten healing time but had fewer serious complications (no perforations or recurrences) than antimicrobials alone.
Within-subject randomized trial in children found single-application bovine collagen dressings were safe and as effective as human amniotic membrane for superficial partial-thickness burns (healing time and scarring similar).
Randomized clinical trial (45 patients) comparing porcine-derived collagen matrix to connective tissue graft with immediate implants; esthetic scores and clinical parameters were comparable at 1 year.
Randomized clinical trial comparing collagen plug, demineralized bone matrix (Grafton) and particulate autogenous+DBBM (MinerOss X) with vestibular socket therapy in immediate implants; all groups had good esthetic outcomes and increased facial bone thickness, with no significant differences between groups.
In 74 postmenopausal women, bisphosphonate therapy (clodronate or yearly zoledronate) reduced bone turnover markers and produced differential effects on Wnt inhibitors (transient DKK1 increases with zoledronate; delayed SOST increase with clodronate).
Randomized trial in 40 patients showed similar overall patient-reported recovery and OHRQL with Bio-Oss collagen vs no grafting material, but the collagen group had slightly more days of eating/sleep disturbances and pain.
Randomized trial in 40 patients showed similar overall patient-reported recovery and OHRQL with Bio-Oss collagen vs no grafting material, but the collagen group had slightly more days of eating/sleep disturbances and pain.
Randomized trial in 40 patients showed similar overall patient-reported recovery and OHRQL with Bio-Oss collagen vs no grafting material, but the collagen group had slightly more days of eating/sleep disturbances and pain.
Randomized trial in spinal surgery patients showing the collagen-based topical hemostat CollaStat was noninferior to Floseal for stopping surgical bleeding with no device-related serious adverse events.
Randomized trial of a collagen-based arterial closure device showing faster hemostasis and earlier discharge with similar complication rates.
Randomized trial in spinal surgery patients showing the collagen-based topical hemostat CollaStat was noninferior to Floseal for stopping surgical bleeding with no device-related serious adverse events.
Percutaneous collagen device (VasoSeal) achieved faster hemostasis but had more minor local complications and lower technical success than mechanical compression.
Collagen plug (VasoSeal) after PTCA markedly shortened time to hemostasis but overall local complication rates were similar, with a possible increase in large hematomas.
Collagen plug (VasoSeal) markedly shortened time to hemostasis after PTCA versus manual compression, with similar overall local complication rates.
Using a collagen plug after catheterization shortened bleeding time and caused less pain with similar complication rates.
A collagen-derived hemostatic gel (Floseal) produced faster hemostasis, less blood loss, and quicker return to diet than cautery in children having adenoidectomy.
Replacing methotrexate with daily oral collagen type II (0.5 mg) worsened disease activity in patients with long-standing rheumatoid arthritis.
A collagen corneal shield gave worse device performance and more adverse events than a hydrogel bandage, while pain scores were similar.
Randomized trial in spinal surgery patients showing the collagen-based topical hemostat CollaStat was noninferior to Floseal for stopping surgical bleeding with no device-related serious adverse events.
Injecting collagen into masseter trigger points reduced pain and muscle activity more than lidocaine or saline over a 2-week observation.
Artecoll (PMMA microspheres + bovine collagen) produced greater and longer-lasting wrinkle augmentation and higher satisfaction than standard collagen filler with acceptable safety.
In patients with active rheumatoid arthritis, oral chicken type II collagen (CCII) was effective but less so than methotrexate (MTX) over 24 weeks and was associated with fewer and milder adverse events.
Randomized clinical trial (30 patients) comparing open flap debridement, L-PRF, and L-PRF plus collagen membrane; all groups improved clinically, and the collagen-membrane group had greater radiographic defect fill but no sustained difference in crevicular PDGF/VEGF levels.
12-month RCT (51 subjects) showed guided tissue regeneration with collagen membrane improved probing depth and clinical attachment versus open flap debridement, but collagen membrane increased gingival recession compared with other treatments.
Both HA/collagen (Biostite) and bovine HA (Bio-Oss) grafts produced similar, significant improvements in pocket depth, clinical attachment, and defect fill at 12 months.
In 45 patients with bilateral impacted lower third molars, use of bovine porous bone mineral with or without a collagen membrane reduced pocket depth and gained attachment versus untreated controls over long follow‑up.
Using a bovine bone graft plus a collagen membrane improved pocket depth and attachment in people with one intrabony periodontal defect after 1 year.
Randomized trial in periodontitis patients showed similar pocket depth and attachment gains for both barriers but greater bone fill with the collagen membrane at 6 months.
Randomized clinical trial (30 patients) comparing open flap debridement, L-PRF, and L-PRF plus collagen membrane; all groups improved clinically, and the collagen-membrane group had greater radiographic defect fill but no sustained difference in crevicular PDGF/VEGF levels.
Randomized clinical trial (30 patients) comparing open flap debridement, L-PRF, and L-PRF plus collagen membrane; all groups improved clinically, and the collagen-membrane group had greater radiographic defect fill but no sustained difference in crevicular PDGF/VEGF levels.
Double-blind RCT in 99 women showing daily oral collagen peptides for 12 weeks increased skin water content and natural moisturizing factor and reduced transepidermal water loss; elasticity and thickness unchanged.
Double-blind RCT in 99 women showing daily oral collagen peptides for 12 weeks increased skin water content and natural moisturizing factor and reduced transepidermal water loss; elasticity and thickness unchanged.
Small randomized double‑blind placebo‑controlled trial of an oral fish‑derived collagen peptide plus ornithine drink given nightly for 8 weeks in adults with low skin moisture/elasticity, measuring skin elasticity, TEWL, pores, and IGF‑1.
Daily oral collagen tripeptide (3 g) improved skin hydration and elasticity and tended to reduce transepidermal water loss over 12 weeks compared with no supplement.
Topical product containing collagen tripeptide improved objective skin barrier measures and reduced symptoms of sensitive atopic skin versus placebo over 4 weeks.
Randomized double-blind placebo-controlled 12-week trial of an oral plant-derived 'collagen alternative' (VC-H1) showing improvements in skin hydration, barrier function, and elasticity.
Double-blind RCT in 99 women showing daily oral collagen peptides for 12 weeks increased skin water content and natural moisturizing factor and reduced transepidermal water loss; elasticity and thickness unchanged.
Randomized trial (44 patients) comparing a volume-stable collagen matrix (VCMX) to connective tissue graft (CTG) during implant placement at sites with small buccal dehiscences: both increased soft-tissue volume, CTG gave slightly more stable gains and greater keratinized tissue width while VCMX caused less short-term pain/bleeding.
Randomized trial (44 patients) comparing a volume-stable collagen matrix (VCMX) to connective tissue graft (CTG) during implant placement at sites with small buccal dehiscences: both increased soft-tissue volume, CTG gave slightly more stable gains and greater keratinized tissue width while VCMX caused less short-term pain/bleeding.
Randomized trial (44 patients) comparing a volume-stable collagen matrix (VCMX) to connective tissue graft (CTG) during implant placement at sites with small buccal dehiscences: both increased soft-tissue volume, CTG gave slightly more stable gains and greater keratinized tissue width while VCMX caused less short-term pain/bleeding.
Within-patient randomized study (30 patients) comparing volume-stable collagen matrix (VCMX) to autogenous connective tissue graft (CTG) for root coverage: CTG achieved higher percent root coverage while VCMX caused less postoperative pain and was preferred by patients.
Both techniques with acellular dermal matrix improved root coverage; coronally positioned flap gave higher mean coverage than the tunnel technique at 4 months.
Within-patient randomized study (30 patients) comparing volume-stable collagen matrix (VCMX) to autogenous connective tissue graft (CTG) for root coverage: CTG achieved higher percent root coverage while VCMX caused less postoperative pain and was preferred by patients.
Within-patient randomized study (30 patients) comparing volume-stable collagen matrix (VCMX) to autogenous connective tissue graft (CTG) for root coverage: CTG achieved higher percent root coverage while VCMX caused less postoperative pain and was preferred by patients.
Randomized trial comparing PRF membrane versus collagen membrane after oral mucosal excision; PRF showed less pain and faster healing at early time points.
Randomized clinical study (60 patients) comparing PRF, PRF+collagen plug, and control after tooth extraction; evaluated ridge dimensions and postoperative pain.
Randomized clinical trial (63 enrolled, 58 available for follow-up) comparing apically positioned flap, free gingival graft (FGG), and a collagen matrix to increase keratinized mucosa before implant prosthesis; outcomes at 4 weeks.
In infants with deep second-degree facial/neck burns, topical medical collagen sponge had similar or slightly faster healing but higher wound bacterial positivity compared with rhGM-CSF; combination therapy (rhGM-CSF + collagen sponge) performed best.
Randomized trial: topical recombinant human EGF accelerated healing of diabetic foot ulcers, with greater collagen/fibroblast development in treated wounds.
Randomised trial showing primary closure with collagen‑gentamicin implant reduced surgical wound infections and shortened healing time versus open wound care in contaminated abdominal wounds.
In infants with deep second-degree facial/neck burns, topical medical collagen sponge had similar or slightly faster healing but higher wound bacterial positivity compared with rhGM-CSF; combination therapy (rhGM-CSF + collagen sponge) performed best.
In infants with deep second-degree facial/neck burns, topical medical collagen sponge had similar or slightly faster healing but higher wound bacterial positivity compared with rhGM-CSF; combination therapy (rhGM-CSF + collagen sponge) performed best.
In open tibia fractures with bone defects, rhBMP-2 delivered on an absorbable collagen sponge showed lower radiographic union and clinical healing rates and more complications than autologous bone graft.
In open tibia fractures with bone defects, rhBMP-2 delivered on an absorbable collagen sponge showed lower radiographic union and clinical healing rates and more complications than autologous bone graft.
Multicenter randomized trial showing a percutaneous collagen hemostasis device substantially reduced puncture-site hemostasis time and shortened time to ambulation versus manual compression, without increasing major complications.
Small randomized trial comparing resorbable collagen barriers supported by plates versus titanium-reinforced nonresorbable barriers for vertical ridge augmentation; both achieved bone gain but complications occurred in both groups.
In open tibia fractures with bone defects, rhBMP-2 delivered on an absorbable collagen sponge showed lower radiographic union and clinical healing rates and more complications than autologous bone graft.
Topical high‑molecular‑weight hyaluronic acid after third molar extraction reduced local inflammatory cell infiltration and increased angiogenesis at 1 week, with no change in pain or oxidative stress markers at that time point.
In this interim analysis, standard collagen alginate dressing (control) had substantially lower 12-week ulcer closure rates than acellular fish skin graft (31.3% vs 63.0%).
In this interim analysis, standard collagen alginate dressing (control) had substantially lower 12-week ulcer closure rates than acellular fish skin graft (31.3% vs 63.0%).
In this interim analysis, standard collagen alginate dressing (control) had substantially lower 12-week ulcer closure rates than acellular fish skin graft (31.3% vs 63.0%).
A xenogeneic collagen matrix increased keratinized mucosa width and reduced patient pain compared with autologous grafts, but gained less KM (1.6 mm vs 2.5 mm); probing depth reductions were similar.
Both PRF and PLA-PGA membranes combined with hydroxyapatite crystal collagen-fiber graft led to significant defect improvement at 6 months, with no significant difference between membranes.
A xenogeneic collagen matrix increased keratinized mucosa width and reduced patient pain compared with autologous grafts, but gained less KM (1.6 mm vs 2.5 mm); probing depth reductions were similar.
A xenogeneic collagen matrix increased keratinized mucosa width and reduced patient pain compared with autologous grafts, but gained less KM (1.6 mm vs 2.5 mm); probing depth reductions were similar.
Topical thrombin-collagen combined with autologous PRP did not reduce perioperative blood loss or transfusion rates in primary total hip arthroplasty compared with standard care.
Topical thrombin-collagen combined with autologous PRP did not reduce perioperative blood loss or transfusion rates in primary total hip arthroplasty compared with standard care.
Topical thrombin-collagen combined with autologous PRP did not reduce perioperative blood loss or transfusion rates in primary total hip arthroplasty compared with standard care.
12-week randomized placebo-controlled trial: small-dose undenatured type II collagen improved knee flexibility, reduced joint discomfort, and improved motor function versus placebo.
Daily collagen hydrolysate (10 g) for 6 months reduced knee pain and improved joint comfort in people with knee osteoarthritis.
After HA injection, adding an oral collagen-containing viscosupplement tended to improve symptoms and reduced patients' use of painkillers more than HA alone.
12 weeks of collagen peptide (10 g/day) did not reduce knee pain or change biomarkers versus placebo in active middle-aged to older adults.
12 weeks of collagen peptide (10 g/day) did not reduce knee pain or change biomarkers versus placebo in active middle-aged to older adults.
12 weeks of collagen peptide (10 g/day) did not reduce knee pain or change biomarkers versus placebo in active middle-aged to older adults.
Xenogeneic collagen matrix (XCM) produced similar keratinized mucosa width but thinner mucosa, higher shrinkage, and better esthetics than free gingival graft at 6 months.
Xenogeneic collagen matrix (XCM) produced similar keratinized mucosa width but thinner mucosa, higher shrinkage, and better esthetics than free gingival graft at 6 months.
Xenogeneic collagen matrix (XCM) produced similar keratinized mucosa width but thinner mucosa, higher shrinkage, and better esthetics than free gingival graft at 6 months.
For small head-and-neck skin defects, xenogeneic collagen matrix produced non-inferior scar outcomes at 6 months compared with skin grafts.
In men with idiopathic osteoporosis, daily intranasal salmon calcitonin increased lumbar spine BMD and suppressed bone resorption markers over 12 months.
Long‑term extension of ibandronate treatment showing sustained increases in lumbar spine and hip BMD and persistent reductions in type I collagen turnover markers over 3 years.
Five years of risedronate reduced bone turnover markers and increased lumbar spine BMD, with no pathologic biopsy findings.
Alendronate prevented periprosthetic BMD loss around femoral implants and reduced serum N-terminal telopeptides of type-1 collagen; alfacalcidol preserved lumbar spine BMD but did not prevent periprosthetic loss.
Multicenter randomized trial of once-weekly alendronate in postmenopausal Chinese women; not designed to test Vitamin D effects.
Twelve weeks of maximal squat strength training increased lumbar spine and hip BMD and raised a bone formation marker and strength outcomes in young women.
Randomized trial of neridronate vs control in thalassaemia-associated osteoporosis; both groups received calcium + 400 IU vitamin D daily; neridronate increased BMD and reduced bone turnover and back pain.
Ibandronate and alendronate both increased BMD over 1 year; all women also received daily calcium and vitamin D 200 IU.
Alendronate prevented glucocorticoid-induced bone loss, increasing BMD at spine and hip sites over 24 weeks compared with calcium alone.
Oral alendronate and yearly zoledronic acid similarly increased bone density and strongly reduced bone resorption biomarkers in adults with osteogenesis imperfecta.
Short-term (3-month) patient-reported satisfaction favored Alloderm over Dermacell, but differences were not present at 12 months.
Short-term (3-month) patient-reported satisfaction favored Alloderm over Dermacell, but differences were not present at 12 months.
Short-term (3-month) patient-reported satisfaction favored Alloderm over Dermacell, but differences were not present at 12 months.
Both treatments improved peri-implantitis clinical and radiographic outcomes, with the collagen membrane group showing better PD, CAL and vertical defect depth at 12 months.
Both treatments improved peri-implantitis clinical and radiographic outcomes, with the collagen membrane group showing better PD, CAL and vertical defect depth at 12 months.
Both treatments improved peri-implantitis clinical and radiographic outcomes, with the collagen membrane group showing better PD, CAL and vertical defect depth at 12 months.
Protein-enhancing strategies (including hydrolysed collagen) increased daily protein intake shortly after bariatric surgery; hydrolysed collagen had the best tolerability and satisfaction but whey produced the largest intake increase.
Protein-enhancing strategies (including hydrolysed collagen) increased daily protein intake shortly after bariatric surgery; hydrolysed collagen had the best tolerability and satisfaction but whey produced the largest intake increase.
Protein-enhancing strategies (including hydrolysed collagen) increased daily protein intake shortly after bariatric surgery; hydrolysed collagen had the best tolerability and satisfaction but whey produced the largest intake increase.
Higher blood markers of collagen turnover were linked to worse walking distance and higher risk of death or hospitalization in chronic heart failure patients.
In 30 patients, combining a free gingival graft strip with a xenogeneic collagen matrix increased keratinized mucosa; gains were significant versus baseline but between-group differences in width were not significant, while esthetics and morbidity favored the combination.
In 30 patients, combining a free gingival graft strip with a xenogeneic collagen matrix increased keratinized mucosa; gains were significant versus baseline but between-group differences in width were not significant, while esthetics and morbidity favored the combination.
In 30 patients, combining a free gingival graft strip with a xenogeneic collagen matrix increased keratinized mucosa; gains were significant versus baseline but between-group differences in width were not significant, while esthetics and morbidity favored the combination.
Secondary analysis of 33 patients (48 implants) found defect angle strongly predicted radiographic bone gain after reconstructive therapy using allograft ± collagen membrane, while other defect metrics did not.
In periodontal intraosseous defects, adding a collagen membrane to enamel matrix protein therapy did not improve clinical or radiographic outcomes compared with either therapy alone.
Minimally invasive periodontal surgery produced clinical attachment gains at 1 year; adding deproteinized bovine bone mineral plus a collagen membrane did not improve 1-year outcomes versus surgery alone.
Secondary analysis of 33 patients (48 implants) found defect angle strongly predicted radiographic bone gain after reconstructive therapy using allograft ± collagen membrane, while other defect metrics did not.
In 36 split-mouth patients, both pinhole technique with collagen membrane and coronally advanced flap with connective tissue graft achieved comparable root coverage at 1 year with no significant difference in efficacy.
Adding a collagen matrix to flap surgery for gingival recession with cervical lesions gave similar coverage but increased keratinized tissue width and thickness.
In 36 split-mouth patients, both pinhole technique with collagen membrane and coronally advanced flap with connective tissue graft achieved comparable root coverage at 1 year with no significant difference in efficacy.
In 36 split-mouth patients, both pinhole technique with collagen membrane and coronally advanced flap with connective tissue graft achieved comparable root coverage at 1 year with no significant difference in efficacy.
In 32 patients, a xenogeneic collagen matrix (VXCM) produced greater soft tissue thickness gain at 3 months but less gain at 6 months compared with connective tissue graft (SCTG); SCTG had better aesthetic scores and early pain was higher with SCTG.
In 32 patients, a xenogeneic collagen matrix (VXCM) produced greater soft tissue thickness gain at 3 months but less gain at 6 months compared with connective tissue graft (SCTG); SCTG had better aesthetic scores and early pain was higher with SCTG.
In 32 patients, a xenogeneic collagen matrix (VXCM) produced greater soft tissue thickness gain at 3 months but less gain at 6 months compared with connective tissue graft (SCTG); SCTG had better aesthetic scores and early pain was higher with SCTG.
In a randomized double-blind trial (initial n=90, 81 completed), daily 2000 mg skate-derived collagen peptides for 12 weeks produced small but statistically significant reductions in body fat versus placebo.
In a randomized double-blind trial (initial n=90, 81 completed), daily 2000 mg skate-derived collagen peptides for 12 weeks produced small but statistically significant reductions in body fat versus placebo.
In a randomized double-blind trial (initial n=90, 81 completed), daily 2000 mg skate-derived collagen peptides for 12 weeks produced small but statistically significant reductions in body fat versus placebo.
Using a collagen matrix or enamel matrix with flap surgery improved gum root coverage and gingival thickness compared with flap alone.
Using a collagen matrix or enamel matrix with flap surgery improved gum root coverage and gingival thickness compared with flap alone.
Daily collagen hydrolysate (10 g) for 6 months reduced knee pain and improved joint comfort in people with knee osteoarthritis.
Different antihypertensive regimens produced divergent changes in circulating natriuretic peptides and some collagen turnover markers over years.
Different antihypertensive regimens produced divergent changes in circulating natriuretic peptides and some collagen turnover markers over years.
Polychromatic red/near‑infrared light therapy twice weekly improved skin appearance and increased intradermal collagen density versus controls.
Polychromatic red/near‑infrared light therapy twice weekly improved skin appearance and increased intradermal collagen density versus controls.
In women taking monophasic oral contraceptives, a transient decrease in a type I collagen synthesis marker (PICP) was observed with the lower-ethinyl-estradiol formulation after three cycles and normalized by six months; degradation marker (ICTP) was unchanged.
Changes in serum markers of type I collagen (ICTP and PICP) correlated with treatment response in patients with bone metastases from breast cancer.
In 39 older sedentary adults, 10 weeks of moderate or higher-intensity aerobic training did not change serum markers of collagen synthesis or degradation.
Changes in serum markers of type I collagen (ICTP and PICP) correlated with treatment response in patients with bone metastases from breast cancer.
Adding a collagen matrix to flap surgery for gingival recession with cervical lesions gave similar coverage but increased keratinized tissue width and thickness.
Adding a collagen matrix to flap surgery for gingival recession with cervical lesions gave similar coverage but increased keratinized tissue width and thickness.
In early RA, higher baseline RANKL:OPG ratio and collagen degradation markers predicted faster radiological joint damage over 11 years.
In early rheumatoid arthritis, increases in disease activity were immediately followed by increases in urinary markers of collagen type II (cartilage) and type I (bone) degradation.
In early RA, higher baseline RANKL:OPG ratio and collagen degradation markers predicted faster radiological joint damage over 11 years.
In early rheumatoid arthritis, increases in disease activity were immediately followed by increases in urinary markers of collagen type II (cartilage) and type I (bone) degradation.
Using a collagen matrix on the dura during hemicraniectomy reduced combined operating time and cerebrospinal fluid (CSF) complications without changing rehabilitation outcome.
Using a collagen matrix on the dura during hemicraniectomy reduced combined operating time and cerebrospinal fluid (CSF) complications without changing rehabilitation outcome.
Using a collagen matrix on the dura during hemicraniectomy reduced combined operating time and cerebrospinal fluid (CSF) complications without changing rehabilitation outcome.
Daily syrup containing fish collagen (4 g) plus CoQ10 for 12 weeks increased dermis density and reduced periorbital wrinkles and overall wrinkle score vs placebo.
Daily syrup containing fish collagen (4 g) plus CoQ10 for 12 weeks increased dermis density and reduced periorbital wrinkles and overall wrinkle score vs placebo.
In peri-implantitis surgery, both collagen matrix and autologous free gingival grafts reduced pocket depth and bleeding; autologous grafts produced greater keratinized mucosa gain at 3 years.
Adding a collagen membrane plus bone mineral resulted in more radiographic bone fill but no differences in clinical signs or patient-reported outcomes at 12 months.
Randomized trial in periodontitis patients showed similar pocket depth and attachment gains for both barriers but greater bone fill with the collagen membrane at 6 months.
Randomized trial comparing DBBM vs DBBM + 10% collagen for alveolar ridge preservation; overall mid-facial mucosal level and long-term tissue stability similar between materials, with some early soft tissue thickness advantage for DBBM alone.
At 3 years, Ti-meshes covered with collagen membranes performed similarly to Ti-reinforced d-PTFE membranes for vertical ridge augmentation around implants.
At 3 years, Ti-meshes covered with collagen membranes performed similarly to Ti-reinforced d-PTFE membranes for vertical ridge augmentation around implants.
At 3 years, Ti-meshes covered with collagen membranes performed similarly to Ti-reinforced d-PTFE membranes for vertical ridge augmentation around implants.
Cross-sectional study measuring serum collagen formation and degradation biomarkers in 617 healthy adults shows age- and sex-dependent patterns of collagen turnover (type I, III, IV).
Cross-sectional study measuring serum collagen formation and degradation biomarkers in 617 healthy adults shows age- and sex-dependent patterns of collagen turnover (type I, III, IV).
Cross-sectional study measuring serum collagen formation and degradation biomarkers in 617 healthy adults shows age- and sex-dependent patterns of collagen turnover (type I, III, IV).
Adding leukocyte- and platelet-rich fibrin (with or without occlusive membrane including collagen membrane stratum) to root-end surgery did not improve patient-reported pain, symptoms, activity impairment, or medication use in the first postoperative week.
Adding leukocyte- and platelet-rich fibrin (with or without occlusive membrane including collagen membrane stratum) to root-end surgery did not improve patient-reported pain, symptoms, activity impairment, or medication use in the first postoperative week.
A collagen-based vascular closure device (Vascade) markedly shortened time to hemostasis, ambulation, and discharge and reduced minor access-site complications versus manual compression.
A collagen-based vascular closure device (Vascade) markedly shortened time to hemostasis, ambulation, and discharge and reduced minor access-site complications versus manual compression.
A collagen-based vascular closure device (Vascade) markedly shortened time to hemostasis, ambulation, and discharge and reduced minor access-site complications versus manual compression.
A collagen-based vascular closure device (Vascade) markedly shortened time to hemostasis, ambulation, and discharge and reduced minor access-site complications versus manual compression.
Twelve months of high-impact exercise lowered basal serum PTH but did not change bone turnover markers in premenopausal women.
Twelve-week randomized study: calcium- and vitamin D–fortified milk (higher calcium + vitamin D + FOS-inulin) reduced bone resorption markers and PTH more than regular milk, especially in postmenopausal women.
In people with relapsing-remitting MS, weekly high-dose vitamin D raised vitamin D levels but did not meaningfully change common blood markers of bone formation or resorption over 96 weeks.
Using a bovine type I collagen membrane produced similar vital bone formation and ridge dimensions compared with a human amnion-chorion membrane in ridge preservation.
Using a bovine type I collagen membrane produced similar vital bone formation and ridge dimensions compared with a human amnion-chorion membrane in ridge preservation.
Daily oral collagen tripeptide (3 g) improved skin hydration and elasticity and tended to reduce transepidermal water loss over 12 weeks compared with no supplement.
Daily oral collagen tripeptide (3 g) improved skin hydration and elasticity and tended to reduce transepidermal water loss over 12 weeks compared with no supplement.
In 45 patients with bilateral impacted lower third molars, use of bovine porous bone mineral with or without a collagen membrane reduced pocket depth and gained attachment versus untreated controls over long follow‑up.
Reconstructive surgery for peri-implantitis using a bovine collagen membrane or concentrated growth factor both improved clinical and radiographic outcomes; collagen membrane yielded significantly greater reductions in probing depth and vertical defect depth at 1 and 3 years.
Prospective randomized (non-blinded) trial comparing autogenous demineralized dentin matrix with bio-collagen membrane versus natural healing after lower third molar extraction; test group showed better probing depth and radiographic bone density but slightly greater early swelling.
Residual defect height >1 mm after guided bone regeneration was associated with higher bleeding on probing and tended to increase mucosal recession at 4 years.
Using a bovine bone graft plus a collagen membrane improved pocket depth and attachment in people with one intrabony periodontal defect after 1 year.
12-month RCT (51 subjects) showed guided tissue regeneration with collagen membrane improved probing depth and clinical attachment versus open flap debridement, but collagen membrane increased gingival recession compared with other treatments.
Reconstructive surgery for peri-implantitis using a bovine collagen membrane or concentrated growth factor both improved clinical and radiographic outcomes; collagen membrane yielded significantly greater reductions in probing depth and vertical defect depth at 1 and 3 years.
Residual defect height >1 mm after guided bone regeneration was associated with higher bleeding on probing and tended to increase mucosal recession at 4 years.
In peri-implantitis surgery, both collagen matrix and autologous free gingival grafts reduced pocket depth and bleeding; autologous grafts produced greater keratinized mucosa gain at 3 years.
Reconstructive surgery for peri-implantitis using a bovine collagen membrane or concentrated growth factor both improved clinical and radiographic outcomes; collagen membrane yielded significantly greater reductions in probing depth and vertical defect depth at 1 and 3 years.
In Asian patients with partial meniscal defects, implantation of a collagen meniscal scaffold led to measurable meniscal tissue regeneration over 12 months but clinical scores were similar to partial meniscectomy.
In Asian patients with partial meniscal defects, implantation of a collagen meniscal scaffold led to measurable meniscal tissue regeneration over 12 months but clinical scores were similar to partial meniscectomy.
In Asian patients with partial meniscal defects, implantation of a collagen meniscal scaffold led to measurable meniscal tissue regeneration over 12 months but clinical scores were similar to partial meniscectomy.
In patients undergoing vascular groin incisions, gentamicin-containing collagen implants did not significantly reduce overall surgical site infection (SSI) rates, but post-hoc analysis showed a large reduction in SSIs at high-risk centers.
In patients undergoing vascular groin incisions, gentamicin-containing collagen implants did not significantly reduce overall surgical site infection (SSI) rates, but post-hoc analysis showed a large reduction in SSIs at high-risk centers.
In patients undergoing vascular groin incisions, gentamicin-containing collagen implants did not significantly reduce overall surgical site infection (SSI) rates, but post-hoc analysis showed a large reduction in SSIs at high-risk centers.
Injectable bovine collagen hydrogel carrying mesenchymal stromal cells given at CABG was safe and associated with reduced infarct scar size at 12 months and improved LVEF in patients with low baseline LVEF.
Injectable bovine collagen hydrogel carrying mesenchymal stromal cells given at CABG was safe and associated with reduced infarct scar size at 12 months and improved LVEF in patients with low baseline LVEF.
Injectable bovine collagen hydrogel carrying mesenchymal stromal cells given at CABG was safe and associated with reduced infarct scar size at 12 months and improved LVEF in patients with low baseline LVEF.
Adding a resorbable collagen membrane over customized titanium mesh did not significantly change histological measures of augmented bone after 6 months compared with mesh alone.
Adding a resorbable collagen membrane over customized titanium mesh did not significantly change histological measures of augmented bone after 6 months compared with mesh alone.
In patients with major burns, daily collagen hydrolysate (40 g) with or without omega-3 accelerated wound healing, reduced days to near-complete and complete healing, and improved scar scores versus placebo over four weeks.
In patients with major burns, daily collagen hydrolysate (40 g) with or without omega-3 accelerated wound healing, reduced days to near-complete and complete healing, and improved scar scores versus placebo over four weeks.
A porcine collagen-elastin dermal substitute plus STSG slowed early graft take and epithelialization versus STSG alone but showed improved scar elasticity at 12 months.
In patients with major burns, daily collagen hydrolysate (40 g) with or without omega-3 accelerated wound healing, reduced days to near-complete and complete healing, and improved scar scores versus placebo over four weeks.
Adding cyanoacrylate over a hemostatic collagen sponge on palatal donor sites reduced postoperative pain and analgesic use after graft harvesting.
Using different wound dressings (including a collagen plug control) after palatal graft harvest changed pain and painkiller use; stents and biologic dressings reduced pain and analgesic use.
In 40 patients undergoing sinus augmentation, covering the lateral window with a collagen membrane produced comparable bone formation, surgical outcomes, and patient discomfort to bony wall repositioning.
Daily intake of a specific collagen peptide supplement plus standard periodontal maintenance reduced gum inflammation more than placebo over 3 months.
Daily intake of a specific collagen peptide supplement plus standard periodontal maintenance reduced gum inflammation more than placebo over 3 months.
Daily intake of a specific collagen peptide supplement plus standard periodontal maintenance reduced gum inflammation more than placebo over 3 months.
Placing a resorbable collagen membrane over a bone graft in peri-implant reconstructive surgery did not improve clinical or radiographic outcomes at 12 months and was associated with more short-term complications and pain.
Placing a resorbable collagen membrane over a bone graft in peri-implant reconstructive surgery did not improve clinical or radiographic outcomes at 12 months and was associated with more short-term complications and pain.
Placing a resorbable collagen membrane over a bone graft in peri-implant reconstructive surgery did not improve clinical or radiographic outcomes at 12 months and was associated with more short-term complications and pain.
Oral collagen hydrolysate high in bioactive dipeptides (CH-b) significantly improved pressure ulcer healing (PUSH, PSST, wound area) versus placebo over 16 weeks; a lower-dipeptide product (CH-a) showed smaller benefits.
Oral collagen hydrolysate high in bioactive dipeptides (CH-b) significantly improved pressure ulcer healing (PUSH, PSST, wound area) versus placebo over 16 weeks; a lower-dipeptide product (CH-a) showed smaller benefits.
Oral collagen hydrolysate high in bioactive dipeptides (CH-b) significantly improved pressure ulcer healing (PUSH, PSST, wound area) versus placebo over 16 weeks; a lower-dipeptide product (CH-a) showed smaller benefits.
Oral type II collagen (various low doses) was tested in active rheumatoid arthritis; the lowest dose (20 µg/day) showed a statistically significant increase in response by one composite criterion (Paulus) but overall effects were modest.
Oral type II collagen (various low doses) was tested in active rheumatoid arthritis; the lowest dose (20 µg/day) showed a statistically significant increase in response by one composite criterion (Paulus) but overall effects were modest.
Randomized trial in diabetic foot ulcers compared oxidized regenerated cellulose/collagen dressing, autologous growth factors, and their combination over 8 weeks.
Oral type II collagen (various low doses) was tested in active rheumatoid arthritis; the lowest dose (20 µg/day) showed a statistically significant increase in response by one composite criterion (Paulus) but overall effects were modest.
In 372 adults, autologous fibroblast injections significantly improved nasolabial fold wrinkles versus placebo with mostly mild adverse events.
In patients with ischaemic cardiomyopathy, CRT improved measures of collagen metabolism and cardiac function compared with medical therapy alone.
In patients with ischaemic cardiomyopathy, CRT improved measures of collagen metabolism and cardiac function compared with medical therapy alone.
In patients with ischaemic cardiomyopathy, CRT improved measures of collagen metabolism and cardiac function compared with medical therapy alone.
In postmenopausal women, alendronate produced larger short-term changes in bone turnover markers (including collagen propeptide) than DXA over 6 months.
In postmenopausal women, alendronate produced larger short-term changes in bone turnover markers (including collagen propeptide) than DXA over 6 months.
In postmenopausal women, alendronate produced larger short-term changes in bone turnover markers (including collagen propeptide) than DXA over 6 months.
In children with ALL, intensive chemotherapy and glucocorticoids suppressed bone and collagen turnover markers, with rebound increases after steroid cessation modified by methotrexate.
In children with ALL, intensive chemotherapy and glucocorticoids suppressed bone and collagen turnover markers, with rebound increases after steroid cessation modified by methotrexate.
In children with ALL, intensive chemotherapy and glucocorticoids suppressed bone and collagen turnover markers, with rebound increases after steroid cessation modified by methotrexate.
In 30 women, combined acupotomy subcision plus hyaluronic acid produced greater increases in skin collagen and elasticity and greater wrinkle improvement than either treatment alone.
In 30 women, combined acupotomy subcision plus hyaluronic acid produced greater increases in skin collagen and elasticity and greater wrinkle improvement than either treatment alone.
Adding bone marrow aspirate in a hydroxyapatite–collagen sponge led to faster bone regeneration and less postoperative morbidity in maxillofacial cystic defects compared with hydroxyapatite alone.
Adding bone marrow aspirate in a hydroxyapatite–collagen sponge led to faster bone regeneration and less postoperative morbidity in maxillofacial cystic defects compared with hydroxyapatite alone.
Adding bone marrow aspirate in a hydroxyapatite–collagen sponge led to faster bone regeneration and less postoperative morbidity in maxillofacial cystic defects compared with hydroxyapatite alone.
In men with idiopathic osteoporosis, daily intranasal salmon calcitonin increased lumbar spine BMD and suppressed bone resorption markers over 12 months.
In men with idiopathic osteoporosis, daily intranasal salmon calcitonin increased lumbar spine BMD and suppressed bone resorption markers over 12 months.
In 39 older sedentary adults, 10 weeks of moderate or higher-intensity aerobic training did not change serum markers of collagen synthesis or degradation.
In 39 older sedentary adults, 10 weeks of moderate or higher-intensity aerobic training did not change serum markers of collagen synthesis or degradation.
In 72 biliary tract cancer patients, multiple serum collagen-fragment biomarkers were elevated versus controls; PRO-C3 showed excellent diagnostic performance and PRO-C8 strongly predicted worse survival.
In 72 biliary tract cancer patients, multiple serum collagen-fragment biomarkers were elevated versus controls; PRO-C3 showed excellent diagnostic performance and PRO-C8 strongly predicted worse survival.
In 72 biliary tract cancer patients, multiple serum collagen-fragment biomarkers were elevated versus controls; PRO-C3 showed excellent diagnostic performance and PRO-C8 strongly predicted worse survival.
Double-blind RCT: a multi-ingredient supplement (included 300 mg calcium citrate) plus resistance training increased lean body mass and some upper-body muscle size measures more than an isonitrogenous placebo.
In 83 patients undergoing endoanal advancement flap repair, adding local gentamicin-collagen did not significantly improve 1-year healing rates compared to surgery alone.
In cohorts totalling 225 subjects (discovery and validation), specific collagen- and vimentin-derived serum fragments differentiated Crohn's disease from ulcerative colitis and non-IBD controls with good diagnostic accuracy.
In cohorts totalling 225 subjects (discovery and validation), specific collagen- and vimentin-derived serum fragments differentiated Crohn's disease from ulcerative colitis and non-IBD controls with good diagnostic accuracy.
In cohorts totalling 225 subjects (discovery and validation), specific collagen- and vimentin-derived serum fragments differentiated Crohn's disease from ulcerative colitis and non-IBD controls with good diagnostic accuracy.
Adding rhBMP-2 delivered on an absorbable collagen sponge did not significantly accelerate fracture healing and showed a non‑significant trend toward higher infection.
Placing a gentamicin-containing collagen sponge into the wound after pilonidal sinus surgery sped healing and reduced infections and recurrences compared with oral antibiotics alone.
Multicentre RCT comparing dPTFE vs collagen membrane for lateral bone augmentation at anterior maxilla; similar alveolar width outcomes but higher infection with dPTFE.
In 50 patients randomized to ACHA versus Restylane, the amino-acid cross-linked HA filler promoted dermal fibroblast activity, increased skin thickness and collagen generation and provided longer-lasting volume.
Daily low-dose bovine type II collagen (0.5 mg) modestly improved rheumatoid arthritis activity over 6 months.
Oral chicken type II collagen (0.25 mg/day) showed no statistically significant benefit over placebo in active rheumatoid arthritis over 6 months.
Adding low‑dose oral bovine type II collagen to existing rheumatoid arthritis therapy did not improve outcomes versus placebo over 6 months.
Daily low-dose bovine type II collagen (0.5 mg) modestly improved rheumatoid arthritis activity over 6 months.
RCT comparing immediate implants with or without DBBM-C (10% collagen); adding DBBM-C slightly reduced tissue dimensional changes with one significant benefit at the distal papilla.
Exogenous growth hormone increased blood markers of bone and collagen turnover in healthy adults in a dose-dependent manner.
Exogenous growth hormone increased blood markers of bone and collagen turnover in healthy adults in a dose-dependent manner.
Short randomized trial showing rosiglitazone reduces biochemical markers of bone formation (including a procollagen marker) and decreases hip BMD in postmenopausal women.
In ART‑naive HIV patients who completed follow‑up, starting antiretroviral therapy (especially PI‑containing regimens) was associated with early fat mass gain and an early drop in lumbar spine BMD; vitamin D was measured but not an intervention.
In Mexican postmenopausal women with osteoporosis, bazedoxifene markedly reduced bone turnover markers including a collagen resorption marker versus placebo at 12 months.
Exogenous growth hormone increased blood markers of bone and collagen turnover in healthy adults in a dose-dependent manner.
Daily marine collagen peptides (13 g) for 3 months improved blood glucose, lipid profile, and some inflammatory/adipokine markers in patients with type 2 diabetes.
Daily marine collagen peptides (13 g) for 3 months improved blood glucose, lipid profile, and some inflammatory/adipokine markers in patients with type 2 diabetes.
Daily marine collagen peptides (13 g) for 3 months improved blood glucose, lipid profile, and some inflammatory/adipokine markers in patients with type 2 diabetes.
Artecoll (PMMA microspheres + bovine collagen) produced greater and longer-lasting wrinkle augmentation and higher satisfaction than standard collagen filler with acceptable safety.
Artecoll (PMMA microspheres + bovine collagen) produced greater and longer-lasting wrinkle augmentation and higher satisfaction than standard collagen filler with acceptable safety.
Transdermal estradiol+levonorgestrel increased BMD (lumbar spine, hip, total body) and reduced bone turnover markers over 2 years.
In osteopenic postmenopausal women receiving calcium/magnesium/calcitriol, red clover extract plus probiotics reduced lumbar spine BMD loss and improved bone turnover and estrogen metabolite profile versus placebo.
PTH therapy increased early collagen-formation markers and larger short-term increases predicted greater spine and hip BMD gains at 1 year.
In people ≥50 years with joint pain, 1200 mg/day collagen hydrolysate increased the proportion of clinical responders at 6 months versus placebo.
In people ≥50 years with joint pain, 1200 mg/day collagen hydrolysate increased the proportion of clinical responders at 6 months versus placebo.
Double‑blind RCT of hydrolyzed chicken type II collagen (2.5 g/day) versus placebo in adults with joint discomfort over 8 weeks; assessed pain, stiffness, and function.
In patients with knee/hip OA, BioCell Collagen (2 g/day) over 70 days reduced pain and improved WOMAC and physical function versus placebo.
Four weeks of an oral supplement containing hydrolyzed collagen type II plus HA and CS reduced pain scores and decreased some inflammatory cytokines in synovial fluid of knee OA patients.
In patients with knee/hip OA, BioCell Collagen (2 g/day) over 70 days reduced pain and improved WOMAC and physical function versus placebo.
In patients with knee/hip OA, BioCell Collagen (2 g/day) over 70 days reduced pain and improved WOMAC and physical function versus placebo.
In oral soft tissue repair, a gelatin/polycaprolactone membrane was noninferior to a collagen membrane for Grade A healing at 1 month, with similar secondary outcomes and adverse events.
In oral soft tissue repair, a gelatin/polycaprolactone membrane was noninferior to a collagen membrane for Grade A healing at 1 month, with similar secondary outcomes and adverse events.
A collagen fleece (Sangustop) was noninferior to a carrier-bound fibrin sealant for achieving surgical hemostasis after liver resection; safety was similar.
A collagen fleece (Sangustop) was noninferior to a carrier-bound fibrin sealant for achieving surgical hemostasis after liver resection; safety was similar.
A collagen fleece (Sangustop) was noninferior to a carrier-bound fibrin sealant for achieving surgical hemostasis after liver resection; safety was similar.
Placement of a collagen hemostatic sponge in palatal donor sites yielded similar early wound healing, bleeding, and pain whether sutured or not.
Placement of a collagen hemostatic sponge in palatal donor sites yielded similar early wound healing, bleeding, and pain whether sutured or not.
Placement of a collagen hemostatic sponge in palatal donor sites yielded similar early wound healing, bleeding, and pain whether sutured or not.
Using different wound dressings (including a collagen plug control) after palatal graft harvest changed pain and painkiller use; stents and biologic dressings reduced pain and analgesic use.
Using different wound dressings (including a collagen plug control) after palatal graft harvest changed pain and painkiller use; stents and biologic dressings reduced pain and analgesic use.
Randomized trial in 120 children (9–12 y): a protein-rich multi-nutrient drink plus rope-skipping attenuated seasonal forearm BMD loss vs rope-skipping alone and modulated PTH and IGF-1 changes.
Single 1000 mg calcium dose from milk or calcium carbonate acutely reduced bone resorption (CTX-1) and lowered PTH in postmenopausal women regardless of visceral fat.
Drinking bicarbonate-rich (alkaline) mineral water for 2–4 weeks reduced serum CTX and PTH compared with an acidic calcium-rich water in young women.
Human-derived collagen injections improved nasolabial wrinkles, but improvements were smaller and less durable than with injectable PLLA.
In a randomized study of 47 hips, two bone cements showed similar clinical performance; collagen‑related bone turnover markers (PICP, ICTP) rose similarly after surgery at 6 weeks and 6 months.
Study of postmenopausal RA patients (both groups received vitamin D3 and calcium) found resistin associated with markers of inflammation and reduced BMD; HRT transiently increased resistin in year 1.
Minimally invasive periodontal surgery produced clinical attachment gains at 1 year; adding deproteinized bovine bone mineral plus a collagen membrane did not improve 1-year outcomes versus surgery alone.
In combined surgical therapy of peri-implantitis with bone graft and collagen membrane, the choice of debridement/decontamination method (Er:YAG laser vs curets+saline) did not significantly affect 6-month clinical or radiographic outcomes.
Use of a collagen membrane with bovine bone graft improved periodontal pocket depth and attachment over 12 months compared with flap procedure alone.
Adding anorganic bovine bone to a collagen membrane (CPRT) produced greater attachment gains and more vertical bone gain than collagen membrane alone after 1 year.
Adding autogenous bone (with or without bioactive glass) to a collagen membrane led to greater periodontal defect healing than collagen membrane alone.
L-PRF+IBB was non-inferior to collagen membrane+IBB for clinical attachment gain and produced less gingival recession, though it had slightly less probing-depth reduction.
In periodontal defects, GTR using collagen membranes and autogenous periosteal+bone chip treatment both improved probing depth, attachment level, and bone defect fill more than debridement alone; autogenous periosteal approach gave greatest bone gain.
Marine collagen peptide supplementation for 3 months improved glucose control, lipids, insulin sensitivity, and some renal and inflammatory markers in patients with T2DM and hypertension.
Marine collagen peptide supplementation for 3 months improved glucose control, lipids, insulin sensitivity, and some renal and inflammatory markers in patients with T2DM and hypertension.
Marine collagen peptide supplementation for 3 months improved glucose control, lipids, insulin sensitivity, and some renal and inflammatory markers in patients with T2DM and hypertension.
In 88 patients with moderate or severe diabetic foot infections, adding a topical gentamicin-collagen sponge to systemic antibiotics did not significantly change overall clinical cure/improvement or pathogen eradication versus systemic antibiotics alone.
In 88 patients with moderate or severe diabetic foot infections, adding a topical gentamicin-collagen sponge to systemic antibiotics did not significantly change overall clinical cure/improvement or pathogen eradication versus systemic antibiotics alone.
In 88 patients with moderate or severe diabetic foot infections, adding a topical gentamicin-collagen sponge to systemic antibiotics did not significantly change overall clinical cure/improvement or pathogen eradication versus systemic antibiotics alone.
Randomized trial in 120 children (9–12 y): a protein-rich multi-nutrient drink plus rope-skipping attenuated seasonal forearm BMD loss vs rope-skipping alone and modulated PTH and IGF-1 changes.
Multicenter randomized trial of once-weekly alendronate in postmenopausal Chinese women; not designed to test Vitamin D effects.
Urinary NTx tracked antiresorptive effects of HRT and predicted subsequent changes in lumbar and hip BMD in recently postmenopausal women.
Randomized multicenter split-face trial comparing porcine collagen filler (Dermicol-P35) with NASHA; both improved nasolabial fold scores with similar durability at 6 months.
Randomized multicenter split-face trial comparing porcine collagen filler (Dermicol-P35) with NASHA; both improved nasolabial fold scores with similar durability at 6 months.
Randomized clinical trial placing a resorbable collagen barrier in canals of resorbing primary molars; test group had fewer extrusions but the difference was not statistically significant.
In adults with major burns, two weeks of hydrolyzed collagen (with or without fish oil) altered some gut bacterial measures; adding omega-3 prevented loss of Bifidobacterium but overall between-group differences were not significant.
In adults with major burns, two weeks of hydrolyzed collagen (with or without fish oil) altered some gut bacterial measures; adding omega-3 prevented loss of Bifidobacterium but overall between-group differences were not significant.
In adults with major burns, two weeks of hydrolyzed collagen (with or without fish oil) altered some gut bacterial measures; adding omega-3 prevented loss of Bifidobacterium but overall between-group differences were not significant.
In young fit males undergoing eccentric training, replacing part of whey with collagen peptides (20 g) produced no additional benefit versus whey alone for muscle damage markers or recovery of function.
In young fit males undergoing eccentric training, replacing part of whey with collagen peptides (20 g) produced no additional benefit versus whey alone for muscle damage markers or recovery of function.
In young fit males undergoing eccentric training, replacing part of whey with collagen peptides (20 g) produced no additional benefit versus whey alone for muscle damage markers or recovery of function.
In patients with cataract and open‑angle glaucoma, adding a biodegradable collagen‑GAG (Ologen) implant to phaco‑viscocanalostomy produced greater long‑term IOP reduction and higher complete success rates than surgery without the implant.
In patients with cataract and open‑angle glaucoma, adding a biodegradable collagen‑GAG (Ologen) implant to phaco‑viscocanalostomy produced greater long‑term IOP reduction and higher complete success rates than surgery without the implant.
In patients with cataract and open‑angle glaucoma, adding a biodegradable collagen‑GAG (Ologen) implant to phaco‑viscocanalostomy produced greater long‑term IOP reduction and higher complete success rates than surgery without the implant.
Activated collagen (and PRP) produced early wound-score improvements, less blood loss, and fewer complications in high‑risk patients after joint arthroplasty.
Activated collagen (and PRP) produced early wound-score improvements, less blood loss, and fewer complications in high‑risk patients after joint arthroplasty.
Activated collagen (and PRP) produced early wound-score improvements, less blood loss, and fewer complications in high‑risk patients after joint arthroplasty.
Adding a porcine collagen matrix to coronally advanced flap surgery produced similar root coverage but a small increase in soft tissue thickness at 6 months.
In a split-mouth RCT, xenogeneic collagen matrix (XCM) improved root coverage and quality of life but CTG produced greater final gingival thickness and slightly better root-coverage metrics at 18 months.
Adding a porcine collagen matrix to coronally advanced flap surgery produced similar root coverage but a small increase in soft tissue thickness at 6 months.
Adding a porcine collagen matrix to coronally advanced flap surgery produced similar root coverage but a small increase in soft tissue thickness at 6 months.
Using a collagen matrix with a flap slightly increased gum thickness and keratinized tissue but did not significantly improve overall root coverage at 6 months.
Split-mouth randomized trial comparing rhPDGF-BB + beta-TCP + bioabsorbable collagen dressing versus connective tissue graft for gingival recession; both improved clinically, with some measures favoring CTG and others favoring the test.
Adding a xenogeneic collagen matrix to coronally advanced flap surgery increased keratinized tissue width and gingival thickness vs flap alone, while root coverage and patient satisfaction were similar at 12 months.
Using a collagen matrix with a flap slightly increased gum thickness and keratinized tissue but did not significantly improve overall root coverage at 6 months.
Using a collagen matrix with a flap slightly increased gum thickness and keratinized tissue but did not significantly improve overall root coverage at 6 months.
Adding a collagen matrix or an acellular dermal matrix to a coronally advanced flap gave similar root coverage; both matrices increased gingival thickness more than flap alone.
Comparing CGF membrane (sticky bone) to native collagen membrane showed no significant difference in horizontal bone gain at 6 months; CGF membrane was less predictable clinically.
Comparing CGF membrane (sticky bone) to native collagen membrane showed no significant difference in horizontal bone gain at 6 months; CGF membrane was less predictable clinically.
Comparing CGF membrane (sticky bone) to native collagen membrane showed no significant difference in horizontal bone gain at 6 months; CGF membrane was less predictable clinically.
Blood biomarkers of collagen type-3 and type-6 synthesis were higher in IPF patients and were consistently higher in patients with progressive disease; some degradation markers predicted mortality.
Blood biomarkers of collagen type-3 and type-6 synthesis were higher in IPF patients and were consistently higher in patients with progressive disease; some degradation markers predicted mortality.
Blood biomarkers of collagen type-3 and type-6 synthesis were higher in IPF patients and were consistently higher in patients with progressive disease; some degradation markers predicted mortality.
Both PRF and PLA-PGA membranes combined with hydroxyapatite crystal collagen-fiber graft led to significant defect improvement at 6 months, with no significant difference between membranes.
Both PRF and PLA-PGA membranes combined with hydroxyapatite crystal collagen-fiber graft led to significant defect improvement at 6 months, with no significant difference between membranes.
Spironolactone treatment was associated with reductions in serum collagen synthesis biomarkers (notably PICP and, in some analyses, PIIINP), suggesting reduced myocardial collagen synthesis.
Spironolactone treatment was associated with reductions in serum collagen synthesis biomarkers (notably PICP and, in some analyses, PIIINP), suggesting reduced myocardial collagen synthesis.
Adding a collagen matrix or an acellular dermal matrix to a coronally advanced flap gave similar root coverage; both matrices increased gingival thickness more than flap alone.
Adding a collagen matrix or an acellular dermal matrix to a coronally advanced flap gave similar root coverage; both matrices increased gingival thickness more than flap alone.
Adding a collagen/thrombin hemostatic agent during knee replacement reduced the need for blood transfusion compared with standard care.
Injection of lab-expanded, skin-derived collagen-producing cells improved pain and function (VISA score) faster and more than plasma alone in refractory patellar tendinopathy.
Injection of lab-expanded, skin-derived collagen-producing cells improved pain and function (VISA score) faster and more than plasma alone in refractory patellar tendinopathy.
Split-face randomized trial in older women showed microneedle radiofrequency increased non-senescent fibroblasts and procollagen, reduced senescent fibroblasts, and produced greater improvements in wrinkles, elasticity and hydration versus microneedling alone.
Split-face randomized trial in older women showed microneedle radiofrequency increased non-senescent fibroblasts and procollagen, reduced senescent fibroblasts, and produced greater improvements in wrinkles, elasticity and hydration versus microneedling alone.
Split-face randomized trial in older women showed microneedle radiofrequency increased non-senescent fibroblasts and procollagen, reduced senescent fibroblasts, and produced greater improvements in wrinkles, elasticity and hydration versus microneedling alone.
In older adults, 12 months heavy resistance training increased patellar tendon stiffness and preserved material properties compared with moderate/no training; tendon cross-sectional area increased with both training loads, but collagen content and cross-links did not change.
In older adults, 12 months heavy resistance training increased patellar tendon stiffness and preserved material properties compared with moderate/no training; tendon cross-sectional area increased with both training loads, but collagen content and cross-links did not change.
Measured corneal haze after transepithelial corneal collagen cross-linking in keratoconus; haze rose transiently and returned to baseline by one year.
After corneal collagen crosslinking, transient central corneal haze peaked at 1 month and returned to baseline by 6 months.
Transepithelial (epi-on) CXL in keratoconus produced a small but statistically significant flattening of maximum K (−0.9 D) and improved CDVA at 6 months in this small cohort.
Using donor corneas pretreated with corneal collagen cross-linking led to better visual acuity and less myopia/astigmatism after penetrating keratoplasty over 3 years.
Corneal collagen crosslinking improved vision and corneal curvature over one year versus sham (riboflavin alone), with many patients gaining lines of vision and mean K values decreasing.
Two corneal cross-linking procedures stabilized keratoconus over 12 months with modest differences; iontophoresis transepithelial treatment gave significant visual gains but slightly less corneal flattening than standard protocol.
In keratoconus patients, both conventional and accelerated corneal collagen cross-linking using methylcellulose-riboflavin improved visual acuity and maximum keratometry at 2 years with no difference between protocols.
Two CXL methods in progressive keratoconus were compared over 24 months; both stabilized disease but standard (epi-off) CXL produced greater corneal flattening and deeper stromal effects.
Corneal collagen crosslinking reduced keratoconus progression and improved visual acuity at 1 year, with corneal haze as the most common adverse finding.
Prospective randomized study comparing CXL protocols in 138 keratoconus patients found significant improvements in visual and refractive outcomes for several accelerated and conventional protocols at 12 months, with some protocols performing better than others.
In 179 subjects with post-refractive corneal ectasia, corneal collagen crosslinking (CXL) reduced progression and improved vision at 1 year versus sham.
After corneal collagen crosslinking, transient central corneal haze peaked at 1 month and returned to baseline by 6 months.
Clinical trial of corneal collagen cross-linking showing greater corneal flattening and vision improvement when the ectatic cone was centrally located.
In knee OA patients, IA-HA increased urinary CTX-II while NSAID decreased it; both improved symptoms.
Oral Gly‑X‑Y repeat sequences did not show clinically significant benefit versus placebo in active RA.
Oral Gly‑X‑Y repeat sequences did not show clinically significant benefit versus placebo in active RA.
Daily high-calcium mineral water (596 mg Ca) for 6 months lowered PTH and multiple bone turnover markers; adding 400 IU vitamin D provided no additional reduction.
Randomized double-blind trial in postmenopausal women showed risedronate (daily or once-weekly) strongly reduced bone formation and resorption markers over 6 months.
A 12-week within-subject controlled clinical trial (one eye treated, the other as control) found the eye cream containing RFF, N-acetylneuraminic acid and peptides increased periorbital hydration, collagen density and skin elasticity with high participant satisfaction and no adverse effects.
In this randomized, double-blind trial, MAL plus red light increased dermal thickness and showed trends toward improved collagen and elastic tissue histology in photodamaged facial skin, though between-group differences were often non-significant, possibly due to low power.
Five years of risedronate reduced bone turnover markers and increased lumbar spine BMD, with no pathologic biopsy findings.
Randomized trial of neridronate vs control in thalassaemia-associated osteoporosis; both groups received calcium + 400 IU vitamin D daily; neridronate increased BMD and reduced bone turnover and back pain.
Long‑term extension of ibandronate treatment showing sustained increases in lumbar spine and hip BMD and persistent reductions in type I collagen turnover markers over 3 years.
Alendronate increased bone mineral density over 2.5 years; all subjects received calcium and vitamin D but the study did not test vitamin D effects.
Short randomized trial showing rosiglitazone reduces biochemical markers of bone formation (including a procollagen marker) and decreases hip BMD in postmenopausal women.
Once-weekly alendronate significantly increased bone mineral density and reduced bone turnover markers versus calcium alone over one year.
In a small double‑blind RCT, multispectral LED treatment did not show overall superiority vs sham for grade‑2 sacral pressure ulcers; LED increased epidermal thickness and basement membrane measures but wound area changes were similar.
Small double-blind randomized trial in males: short-term collagen peptide supplementation modestly improved jump recovery and tended to reduce muscle soreness but did not affect inflammation or bone turnover markers.
Bovine collagen injections provided temporary wrinkle correction but were less durable and required more volume than hyaluronic acid; side-effect profiles were similar.
Randomized trial comparing bovine collagen (Zyplast) versus hyaluronic acid (Perlane) for nasolabial fold correction; Perlane maintained results longer and caused fewer local reactions.
Randomized trial comparing bovine collagen (Zyplast) versus hyaluronic acid (Perlane) for nasolabial fold correction; Perlane maintained results longer and caused fewer local reactions.
Bovine collagen injections provided temporary wrinkle correction but were less durable and required more volume than hyaluronic acid; side-effect profiles were similar.
Randomized trial comparing bovine collagen (Zyplast) versus hyaluronic acid (Perlane) for nasolabial fold correction; Perlane maintained results longer and caused fewer local reactions.
Intense pulsed light significantly improved clinical photoaging scores and increased collagen fibers on the treated side versus untreated control side.
Collagen cross-linking reduced corneal thickness short-term but provided no sustained improvement in pain, clarity, or vision and had higher rates of recurrent epithelial defects.
Randomized clinical trial in 23 patients with bullous keratopathy comparing accelerated corneal collagen crosslinking (CXL) versus hypertonic saline drops; CXL produced transient thinning of corneal thickness and transiently reduced irritation.
Randomized clinical trial in 23 patients with bullous keratopathy comparing accelerated corneal collagen crosslinking (CXL) versus hypertonic saline drops; CXL produced transient thinning of corneal thickness and transiently reduced irritation.
Randomized clinical trial in 23 patients with bullous keratopathy comparing accelerated corneal collagen crosslinking (CXL) versus hypertonic saline drops; CXL produced transient thinning of corneal thickness and transiently reduced irritation.
Randomized study in chronic periodontitis patients: scaling/root planing plus local minocycline microspheres produced short-term reductions in a collagen degradation product (ICTP) and IL-1 in gingival crevicular fluid.
Randomized study in chronic periodontitis patients: scaling/root planing plus local minocycline microspheres produced short-term reductions in a collagen degradation product (ICTP) and IL-1 in gingival crevicular fluid.
Clinical comparison of antibiotic-containing bovine collagen composite (Targobone) versus autologous bone grafts for mandibular defects; both reduced defect area over 24 weeks, autograft achieved greater final closure.
Randomized trial in 64 nursing-home residents: supplemental oral fluids increased intake but did not increase hydroxyproline (collagen deposition), total body water, or subcutaneous oxygen over 5 days.
Randomized trial in 64 nursing-home residents: supplemental oral fluids increased intake but did not increase hydroxyproline (collagen deposition), total body water, or subcutaneous oxygen over 5 days.
Randomized trial in 64 nursing-home residents: supplemental oral fluids increased intake but did not increase hydroxyproline (collagen deposition), total body water, or subcutaneous oxygen over 5 days.
Multicenter randomized trial comparing rhPDGF-BB combined with beta-tricalcium phosphate–collagen matrix (a calcium phosphate graft substitute) versus autograft for ankle/hindfoot fusion; demonstrated noninferiority.
Multicenter randomized trial comparing rhPDGF-BB combined with beta-tricalcium phosphate–collagen matrix (a calcium phosphate graft substitute) versus autograft for ankle/hindfoot fusion; demonstrated noninferiority.
Multicenter randomized trial comparing rhPDGF-BB combined with beta-tricalcium phosphate–collagen matrix (a calcium phosphate graft substitute) versus autograft for ankle/hindfoot fusion; demonstrated noninferiority.
Atelocollagen injections for partial supraspinatus tears provided greater and more sustained pain relief and better MRI-documented structural improvement than prolotherapy at 3 months.
Randomized trial of trapeziectomy with or without porcine collagen (Permacol) implant; collagen group had frequent adverse reactions and worse clinical outcomes.
Urinary NTx tracked antiresorptive effects of HRT and predicted subsequent changes in lumbar and hip BMD in recently postmenopausal women.
Daily enzymatic hydrolysed collagen (Colatech®) improved knee OA pain and function and was superior to glucosamine over 13 weeks.
Daily enzymatic hydrolysed collagen (Colatech®) improved knee OA pain and function and was superior to glucosamine over 13 weeks.
Daily enzymatic hydrolysed collagen (Colatech®) improved knee OA pain and function and was superior to glucosamine over 13 weeks.
Both membrane strategies supported bone augmentation; nonresorbable membranes produced higher bone density and thinner pseudo‑periosteum than titanium-mesh plus cross-linked collagen membrane.
Small randomized trial comparing resorbable collagen barriers supported by plates versus titanium-reinforced nonresorbable barriers for vertical ridge augmentation; both achieved bone gain but complications occurred in both groups.
Both membrane strategies supported bone augmentation; nonresorbable membranes produced higher bone density and thinner pseudo‑periosteum than titanium-mesh plus cross-linked collagen membrane.
Both membrane strategies supported bone augmentation; nonresorbable membranes produced higher bone density and thinner pseudo‑periosteum than titanium-mesh plus cross-linked collagen membrane.
Tendon samples from torn and uninjured rotator cuffs were compared by FTIR and torn tendons showed altered collagen structure and other chemical changes.
Tendon samples from torn and uninjured rotator cuffs were compared by FTIR and torn tendons showed altered collagen structure and other chemical changes.
Tendon samples from torn and uninjured rotator cuffs were compared by FTIR and torn tendons showed altered collagen structure and other chemical changes.
After extraction, placing a resorbable collagen membrane improved periodontal healing distal to the second molar at 6 months compared with suture alone.
After extraction, placing a resorbable collagen membrane improved periodontal healing distal to the second molar at 6 months compared with suture alone.
After extraction, placing a resorbable collagen membrane improved periodontal healing distal to the second molar at 6 months compared with suture alone.
Single IV zoledronate transiently reduced urinary markers of type II collagen breakdown and markedly suppressed type I collagen resorption markers in Paget's disease patients.
Single IV zoledronate transiently reduced urinary markers of type II collagen breakdown and markedly suppressed type I collagen resorption markers in Paget's disease patients.
Serum NTx shows diurnal variation and is reduced by alendronate (~25% lower over 24 h), demonstrating responsiveness of this collagen-derived bone resorption marker to therapy.
Serum NTx shows diurnal variation and is reduced by alendronate (~25% lower over 24 h), demonstrating responsiveness of this collagen-derived bone resorption marker to therapy.
In elderly osteoporotic women, alendronate increased lumbar BMD and reduced bone resorption more than etidronate; both treatments reduced back pain.
Ospemifene dose-dependently reduced bone resorption and formation markers (collagen-related biochemical markers) over 3 months in postmenopausal women.
In postmenopausal breast cancer patients, tamoxifen reduced markers of bone resorption and formation and increased spine and femoral BMD, whereas toremifene showed smaller effects.
Ospemifene dose-dependently reduced bone resorption and formation markers (collagen-related biochemical markers) over 3 months in postmenopausal women.
Ospemifene dose-dependently reduced bone resorption and formation markers (collagen-related biochemical markers) over 3 months in postmenopausal women.
Corneal collagen crosslinking effectively reduced progression of keratoconus over 5 years, with treated eyes showing decreased keratometry compared to progression in control eyes.
Two corneal cross-linking procedures stabilized keratoconus over 12 months with modest differences; iontophoresis transepithelial treatment gave significant visual gains but slightly less corneal flattening than standard protocol.
Epithelium‑off corneal collagen cross‑linking halted keratoconus progression and reduced maximum K, while transepithelial treatment was less effective and many patients progressed.
Transepithelial (epi-on) CXL in keratoconus produced a small but statistically significant flattening of maximum K (−0.9 D) and improved CDVA at 6 months in this small cohort.
In pediatric keratoconus, both conventional and accelerated CXL improved vision and reduced corneal steepness with no progression over 3 years; differences were most evident at 1 year.
Corneal collagen crosslinking reduced keratoconus progression and improved visual acuity at 1 year, with corneal haze as the most common adverse finding.
Corneal collagen cross-linking improved vision and reduced corneal curvature at 6 months versus sham, with expected cellular changes on confocal microscopy.
Prospective study showing modest flattening of maximum keratometry and regularization of epithelial thickness profile 6 months after epithelium-off CXL.
In keratoconus patients, both conventional and accelerated corneal collagen cross-linking using methylcellulose-riboflavin improved visual acuity and maximum keratometry at 2 years with no difference between protocols.
Adding a biodegradable collagen implant (Ologen) to MMC did not improve IOP lowering compared with MMC alone over 12 months.
Randomized trial comparing atelocollagen implant vs mitomycin C during trabeculectomy; the collagen implant group had less pressure reduction and lower surgical success than MMC.
A porcine collagen implant (Ologen) used during trabeculectomy lowered intraocular pressure similarly to mitomycin‑C over 5 years with comparable safety.
Adding a biodegradable collagen implant (Ologen) to MMC did not improve IOP lowering compared with MMC alone over 12 months.
Oral chicken type II collagen (0.25 mg/day) showed no statistically significant benefit over placebo in active rheumatoid arthritis over 6 months.
Oral chicken type II collagen (0.25 mg/day) showed no statistically significant benefit over placebo in active rheumatoid arthritis over 6 months.
Secondary closure had less swelling and better early mouth opening; membrane-based primary closure was similar to primary closure for immediate discomfort but showed minimal dehiscence and no alveolitis.
Secondary closure had less swelling and better early mouth opening; membrane-based primary closure was similar to primary closure for immediate discomfort but showed minimal dehiscence and no alveolitis.
Secondary closure had less swelling and better early mouth opening; membrane-based primary closure was similar to primary closure for immediate discomfort but showed minimal dehiscence and no alveolitis.
Randomized clinical trial measuring corneal biomechanics up to 1 year after corneal collagen cross-linking (CXL); no meaningful change in measured biomechanical indices at 1 year.
Thrombolytic therapy increased markers of collagen degradation (type III aminoterminal propeptide), with larger rises after streptokinase than tPA; type I propeptide showed transient early decrease then secondary rise.
Thrombolytic therapy increased markers of collagen degradation (type III aminoterminal propeptide), with larger rises after streptokinase than tPA; type I propeptide showed transient early decrease then secondary rise.
Patients post-anterior MI randomized to an aldosterone inhibitor had lower markers of collagen synthesis and less LV dilation over 12 months compared with placebo.
Patients post-anterior MI randomized to an aldosterone inhibitor had lower markers of collagen synthesis and less LV dilation over 12 months compared with placebo.
Randomized trial (2:1) showed the collagen-alginate dressing reduced wound size more than saline gauze and had higher rates of marked reduction and complete healing over 8 weeks.
Randomized trial (2:1) showed the collagen-alginate dressing reduced wound size more than saline gauze and had higher rates of marked reduction and complete healing over 8 weeks.
Randomized trial (2:1) showed the collagen-alginate dressing reduced wound size more than saline gauze and had higher rates of marked reduction and complete healing over 8 weeks.
In randomized carotid endarterectomy, collagen-impregnated Dacron (Hemashield) patching was associated with higher perioperative stroke, thrombosis, and early restenosis rates compared with PTFE, but had shorter hemostasis time.
Randomized trial comparing PTFE patch versus collagen-impregnated Dacron patch during carotid endarterectomy found similar early neurologic event rates but different hemostasis times.
Randomized trial comparing PTFE patch versus collagen-impregnated Dacron patch during carotid endarterectomy found similar early neurologic event rates but different hemostasis times.
Randomized trial comparing PTFE patch versus collagen-impregnated Dacron patch during carotid endarterectomy found similar early neurologic event rates but different hemostasis times.
Six months of inhaled beclomethasone reduced subepithelial type III collagen deposition and MMP-9 while increasing TIMP-1 in bronchial biopsies from asthmatic subjects.
Six months of inhaled beclomethasone reduced subepithelial type III collagen deposition and MMP-9 while increasing TIMP-1 in bronchial biopsies from asthmatic subjects.
Six months of inhaled beclomethasone reduced subepithelial type III collagen deposition and MMP-9 while increasing TIMP-1 in bronchial biopsies from asthmatic subjects.
Prospective human study testing two formats of cross-linked collagen implants for anal fistula repair; both were safe and collagen-fibrin glue had higher long-term healing than solid implant.
Prospective human study testing two formats of cross-linked collagen implants for anal fistula repair; both were safe and collagen-fibrin glue had higher long-term healing than solid implant.
Prospective human study testing two formats of cross-linked collagen implants for anal fistula repair; both were safe and collagen-fibrin glue had higher long-term healing than solid implant.
Multicenter randomized study comparing Juvéderm (HA) to Zyplast collagen for nasolabial fold correction; HA maintained correction longer while Zyplast collagen did not sustain clinically significant correction >9 months.
Multicenter randomized study comparing Juvéderm (HA) to Zyplast collagen for nasolabial fold correction; HA maintained correction longer while Zyplast collagen did not sustain clinically significant correction >9 months.
A randomized trial showing Promogran dressing reduced wound surface area more than control and had a higher (but not statistically significant) healing proportion.
Randomized trial comparing PRF membrane versus collagen membrane after oral mucosal excision; PRF showed less pain and faster healing at early time points.
A protease-modulating collagen-containing dressing led to more frequent and faster healing of neuropathic diabetic foot ulcers versus standard care over 6 weeks.
ORC/collagen matrix applied to pressure sores accelerated healing and reduced protease (elastase and plasmin) activity in wound exudate versus foam dressing control.
A randomized trial showing Promogran dressing reduced wound surface area more than control and had a higher (but not statistically significant) healing proportion.
Within-subject randomized injection study showing porcine and bovine atelocollagen similarly improved nasolabial wrinkle scores at 6 months with manageable local redness.
Within-subject randomized injection study showing porcine and bovine atelocollagen similarly improved nasolabial wrinkle scores at 6 months with manageable local redness.
Randomized study of Ologen (porcine atelocollagen matrix) in DCR surgery showing improved dye clearance and a numerically higher clinical success rate versus control.
Randomized study of Ologen (porcine atelocollagen matrix) in DCR surgery showing improved dye clearance and a numerically higher clinical success rate versus control.
Randomized multicenter study showing porcine-derived ribose-cross-linked collagen filler maintained corrective effect in most subjects up to 9 months and in many up to 12 months.
Randomized multicenter study showing porcine-derived ribose-cross-linked collagen filler maintained corrective effect in most subjects up to 9 months and in many up to 12 months.
Randomized double-blind trial in postmenopausal women showing daily 10 g collagen hydrolysate for 24 weeks did not alter biochemical markers of bone turnover versus placebo.
In 74 postmenopausal women, bisphosphonate therapy (clodronate or yearly zoledronate) reduced bone turnover markers and produced differential effects on Wnt inhibitors (transient DKK1 increases with zoledronate; delayed SOST increase with clodronate).
Randomized double-blind trial in postmenopausal women showing daily 10 g collagen hydrolysate for 24 weeks did not alter biochemical markers of bone turnover versus placebo.
Randomized trial comparing two acellular dermal matrices used in immediate breast reconstruction; clinical outcomes, histology, satisfaction, and costs were similar between groups.
Using a collagen plug after catheterization shortened bleeding time and caused less pain with similar complication rates.
Randomized trial comparing two acellular dermal matrices used in immediate breast reconstruction; clinical outcomes, histology, satisfaction, and costs were similar between groups.
Randomized trial comparing two acellular dermal matrices used in immediate breast reconstruction; clinical outcomes, histology, satisfaction, and costs were similar between groups.
Randomized comparative study showing similar peri-implant buccal bone stability at one year between autogenous bone+DBBM (with collagen membrane) and FDBA (with collagen membrane).
Randomized comparative study showing similar peri-implant buccal bone stability at one year between autogenous bone+DBBM (with collagen membrane) and FDBA (with collagen membrane).
Randomized comparative study showing similar peri-implant buccal bone stability at one year between autogenous bone+DBBM (with collagen membrane) and FDBA (with collagen membrane).
Double-blind randomized placebo-controlled trial (25 men): daily 15 g collagen peptides during 12 weeks resistance training increased absorption marker, fat-free mass, and produced broader proteomic adaptations versus placebo.
Randomized, double-blind 24-week pilot trial in knee OA patients comparing HC-II (type II collagen hydrolysate), EC-HC-II (chicken essence + HC-II), glucosamine, and placebo; HC-II reduced early pain and EC-HC-II increased fat-free mass and grip strength versus some comparators.
Double-blind randomized placebo-controlled trial (25 men): daily 15 g collagen peptides during 12 weeks resistance training increased absorption marker, fat-free mass, and produced broader proteomic adaptations versus placebo.
Twelve weeks of resistance training plus 15 g/day specific collagen peptides increased fat-free mass, reduced fat mass, and improved hand-grip strength more than placebo.
Double-blind randomized placebo-controlled trial (25 men): daily 15 g collagen peptides during 12 weeks resistance training increased absorption marker, fat-free mass, and produced broader proteomic adaptations versus placebo.
Randomized study (30 elderly women) comparing midurethral vs bladder-neck transurethral collagen injections; both improved urethral function and satisfaction with a small advantage for midurethral placement.
Randomized study (30 elderly women) comparing midurethral vs bladder-neck transurethral collagen injections; both improved urethral function and satisfaction with a small advantage for midurethral placement.
Randomised double-blind study comparing porcine/bovine collagen fillers and hyaluronic acid for upper lip wrinkles; all treatments increased lip volume and reduced wrinkles, Perlane showed greatest and most sustained volume.
Randomized study (30 elderly women) comparing midurethral vs bladder-neck transurethral collagen injections; both improved urethral function and satisfaction with a small advantage for midurethral placement.
Double-blind randomized trial of tretinoin 0.05% lotion vs vehicle (vehicle contained soluble collagen among other hydrators) for chest photorejuvenation; both active and vehicle groups improved similarly by 180 days with mild, transient erythema higher in active at day 90.
RCT comparing no graft, connective tissue graft, and xenogeneic collagen matrix at implant placement; no significant differences in esthetic outcomes or peri-implant health at 12 months.
Randomized clinical trial (24 patients) comparing VISTA+A-PRF vs VISTA+collagen matrix: both improved recession outcomes but A-PRF produced larger gains; collagen matrix group showed clinically meaningful but smaller improvements.
Randomized clinical trial (24 patients) comparing VISTA+A-PRF vs VISTA+collagen matrix: both improved recession outcomes but A-PRF produced larger gains; collagen matrix group showed clinically meaningful but smaller improvements.
Randomized clinical trial (24 patients) comparing VISTA+A-PRF vs VISTA+collagen matrix: both improved recession outcomes but A-PRF produced larger gains; collagen matrix group showed clinically meaningful but smaller improvements.
Topical bovine type I collagen matrix (WCM) applied once accelerated healing of refractory diabetic foot ulcers compared with daily saline dressings.
Topical bovine type I collagen matrix (WCM) applied once accelerated healing of refractory diabetic foot ulcers compared with daily saline dressings.
Topical bovine type I collagen matrix (WCM) applied once accelerated healing of refractory diabetic foot ulcers compared with daily saline dressings.
Collagen matrix + flap gave slightly less root coverage than connective tissue graft + flap but similar esthetic satisfaction and keratinized tissue gains.
Collagen matrix + flap gave slightly less root coverage than connective tissue graft + flap but similar esthetic satisfaction and keratinized tissue gains.
Collagen matrix + flap gave slightly less root coverage than connective tissue graft + flap but similar esthetic satisfaction and keratinized tissue gains.
Adding enamel matrix derivative to a collagen membrane did not improve root coverage outcomes compared with collagen membrane alone at 6 months.
Adding enamel matrix derivative to a collagen membrane did not improve root coverage outcomes compared with collagen membrane alone at 6 months.
Adding enamel matrix derivative to a collagen membrane did not improve root coverage outcomes compared with collagen membrane alone at 6 months.
Daily 5 g specific collagen peptides for 6 months improved athletes' self-reported ankle function and reduced re-injury rate, without changing measured mechanical stiffness.
Daily 5 g specific collagen peptides for 6 months improved athletes' self-reported ankle function and reduced re-injury rate, without changing measured mechanical stiffness.
Daily 5 g specific collagen peptides for 6 months improved athletes' self-reported ankle function and reduced re-injury rate, without changing measured mechanical stiffness.
Daily 5 g specific collagen peptides for 6 months improved athletes' self-reported ankle function and reduced re-injury rate, without changing measured mechanical stiffness.
In 45 postmenopausal osteopenic women, a 12-week supervised walking program improved function and increased bone turnover markers (P1NP, CTX) with osteocalcin rising in the exercise group; both groups received vitamin D and calcium.
In two randomized placebo‑controlled studies in 81 postmenopausal women, bedtime GLP‑2 injections produced a dose‑related reduction in the bone resorption marker s‑CTX and a trend toward increased osteocalcin.
Use of a gentamicin-impregnated collagen sponge after marsupialization did not reduce infection, hemorrhage, or healing time compared with control.
A gentamicin-collagen implant used during CABG slightly lowered sternal wound infections but the differences were not statistically significant.
A gentamicin-collagen implant used during CABG slightly lowered sternal wound infections but the differences were not statistically significant.
Randomized study of gentamicin-collagen implant vs control in CABG patients showed a small, nonsignificant reduction in sternal wound infections and mediastinitis with the implant; treatment was safe.
In a randomized study of 47 hips, two bone cements showed similar clinical performance; collagen‑related bone turnover markers (PICP, ICTP) rose similarly after surgery at 6 weeks and 6 months.
Among older adults at risk for heart failure, diabetes was associated with altered collagen biomarkers and diastolic function; spironolactone had modest short-term effects on collagen turnover markers but no major differential long-term effects by diabetes/CAD status.
Adults with GH deficiency had reduced BMD in some subgroups; GH replacement increased bone turnover over 12 months.
Randomized trial in 120 children (9–12 y): a protein-rich multi-nutrient drink plus rope-skipping attenuated seasonal forearm BMD loss vs rope-skipping alone and modulated PTH and IGF-1 changes.
In AGHD patients receiving GH replacement, adding oral phosphate or alendronate increased markers of bone activity and produced greater BMD increases compared with GH alone; vitamin D was not studied.
Graftskin plus compression healed venous ulcers faster and more often than compression alone in a randomized multicenter trial; study concerns a bioengineered skin product rather than collagen supplementation.
Graftskin plus compression healed venous ulcers faster and more often than compression alone in a randomized multicenter trial; study concerns a bioengineered skin product rather than collagen supplementation.
Corneal collagen crosslinking improved vision and corneal curvature over one year versus sham (riboflavin alone), with many patients gaining lines of vision and mean K values decreasing.
Corneal collagen cross-linking improved vision and reduced corneal curvature at 6 months versus sham, with expected cellular changes on confocal microscopy.
Clinical trial of corneal collagen cross-linking showing greater corneal flattening and vision improvement when the ectatic cone was centrally located.
Adding intrastromal collagen cross-linking to hyperopic LASIK reduced long-term regression and gave better uncorrected vision than LASIK alone at 2 years.
In 179 subjects with post-refractive corneal ectasia, corneal collagen crosslinking (CXL) reduced progression and improved vision at 1 year versus sham.
Applying fibrin glue plus a collagen patch after axillary lymphadenectomy reduced seroma size and duration and reduced required evacuative punctures.
Applying fibrin glue plus a collagen patch after axillary lymphadenectomy reduced seroma size and duration and reduced required evacuative punctures.
Applying fibrin glue plus a collagen patch after axillary lymphadenectomy reduced seroma size and duration and reduced required evacuative punctures.
Multicenter randomized trial showing a percutaneous collagen hemostasis device substantially reduced puncture-site hemostasis time and shortened time to ambulation versus manual compression, without increasing major complications.
In peri-implantitis surgery, both collagen matrix and autologous free gingival grafts reduced pocket depth and bleeding; autologous grafts produced greater keratinized mucosa gain at 3 years.
The biodegradable collagen implant (Ologen) provided similar long-term intraocular pressure control to mitomycin-C, with higher bleb height and no observed adverse reaction.
A collagen-based Ologen implant provided similar intraocular pressure control and complication rates as mitomycin‑C over 12 months after trabeculectomy.
In 33 children, adding Ologen (a collagen matrix) to Ahmed valve implantation lowered intraocular pressure more than valve alone over follow-up without added safety issues.
Randomized study of nonpenetrating deep sclerectomy with a collagen implant, comparing adjunctive mitomycin C versus no MMC in glaucoma patients.
Reinforcing anterior colporrhaphy with a bovine pericardium (collagen) graft did not result in a statistically significant improvement in anterior vaginal wall support at 1- or 2-year follow-up.
A collagen-based Ologen implant provided similar intraocular pressure control and complication rates as mitomycin‑C over 12 months after trabeculectomy.
Adding low‑dose oral bovine type II collagen to existing rheumatoid arthritis therapy did not improve outcomes versus placebo over 6 months.
EpiFix (dehydrated amnion/chorion containing collagen and growth factors) produced faster and higher rates of complete healing and lower product costs than Apligraf or standard care in diabetic foot ulcers.
EpiFix (dehydrated amnion/chorion containing collagen and growth factors) produced faster and higher rates of complete healing and lower product costs than Apligraf or standard care in diabetic foot ulcers.
A single application of formulated collagen gel increased early wound‑healing rates in neuropathic diabetic foot ulcers during the first 1–2 weeks compared with standard care, though final closure rates were not significantly different in this exploratory Phase 2 trial.
A single application of formulated collagen gel increased early wound‑healing rates in neuropathic diabetic foot ulcers during the first 1–2 weeks compared with standard care, though final closure rates were not significantly different in this exploratory Phase 2 trial.
Six months of oestradiol in postmenopausal women decreased total vaginal collagen and markers of aged collagen while increasing immature cross-links and MMP-2 expression, indicating stimulated collagen turnover.
Tissue from cesarean hysterotomy edges was compared; the lower edge had higher collagen content but similar biomechanical properties to the upper edge.
Tissue from cesarean hysterotomy edges was compared; the lower edge had higher collagen content but similar biomechanical properties to the upper edge.
Tissue from cesarean hysterotomy edges was compared; the lower edge had higher collagen content but similar biomechanical properties to the upper edge.
Split-face study: fractional CO2 laser + PRP versus hyaluronic acid showed significant clinical improvement on both sides; histology showed increased collagen and elastic fibers, more favorable with PRP.
Split-face study: fractional CO2 laser + PRP versus hyaluronic acid showed significant clinical improvement on both sides; histology showed increased collagen and elastic fibers, more favorable with PRP.
Using DBBM plus a porcine collagen membrane or matrix resulted in less new bone formation at 4 months than unassisted socket healing.
In postmenopausal women, higher ibandronate exposure was associated with larger reductions in bone turnover markers (including collagen C-telopeptides) and greater spine BMD response at 12 months.
In postmenopausal women, higher ibandronate exposure was associated with larger reductions in bone turnover markers (including collagen C-telopeptides) and greater spine BMD response at 12 months.
Once-weekly alendronate significantly increased bone mineral density and reduced bone turnover markers versus calcium alone over one year.
In postmenopausal women, higher ibandronate exposure was associated with larger reductions in bone turnover markers (including collagen C-telopeptides) and greater spine BMD response at 12 months.
Long-term alfacalcidol (vitamin D analog) increased bone mineral density at spine and hip and lowered parathyroid hormone and bone turnover markers in pre-dialysis CRF patients.
Bovine collagen dermal filler provided shorter-lasting nasolabial fold correction than newer HA fillers; most subjects preferred HA.
Bovine collagen dermal filler provided shorter-lasting nasolabial fold correction than newer HA fillers; most subjects preferred HA.
Bio-Oss powder and Bio-Oss collagen produced similar site preservation outcomes after tooth extraction.
Bio-Oss powder and Bio-Oss collagen produced similar site preservation outcomes after tooth extraction.
Percutaneous collagen device (VasoSeal) achieved faster hemostasis but had more minor local complications and lower technical success than mechanical compression.
Percutaneous collagen device (VasoSeal) achieved faster hemostasis but had more minor local complications and lower technical success than mechanical compression.
A collagen-chitosan matrix dressing sped healing of hard-to-heal diabetic foot ulcers compared with saline-moistened gauze.
A collagen-chitosan matrix dressing sped healing of hard-to-heal diabetic foot ulcers compared with saline-moistened gauze.
Collagen plug (VasoSeal) after PTCA markedly shortened time to hemostasis but overall local complication rates were similar, with a possible increase in large hematomas.
Collagen plug (VasoSeal) after PTCA markedly shortened time to hemostasis but overall local complication rates were similar, with a possible increase in large hematomas.
Using a collagen-containing dermal matrix (Integra) with negative pressure wound therapy improved graft take and shortened time to definitive coverage versus Integra alone.
Using a collagen-containing dermal matrix (Integra) with negative pressure wound therapy improved graft take and shortened time to definitive coverage versus Integra alone.
In elective colorectal surgery, adding a gentamicin-collagen sponge to systemic antibiotics lowered postoperative wound infection rates compared with systemic antibiotics alone.
Randomized double-blind pilot trial in men with 20–30% TBSA burns testing an oral hydrolyzed collagen supplement versus isocaloric placebo for 4 weeks; supplement improved markers and wound-healing rate.
Using a collagen-containing dermal matrix (Integra) with negative pressure wound therapy improved graft take and shortened time to definitive coverage versus Integra alone.
Once-monthly oral ibandronate substantially reduced bone resorption markers over 3 months and was well tolerated compared with placebo.
Once-monthly oral ibandronate substantially reduced bone resorption markers over 3 months and was well tolerated compared with placebo.
rbFGF on an absorbable collagen sponge increased closure rates and sped healing of chronic traumatic ulcers without more side effects.
A skin graft product containing a collagen matrix helped long-standing venous leg ulcers heal faster and in more people than standard compression alone.
rbFGF on an absorbable collagen sponge increased closure rates and sped healing of chronic traumatic ulcers without more side effects.
rbFGF on an absorbable collagen sponge increased closure rates and sped healing of chronic traumatic ulcers without more side effects.
ArteFill (PMMA microspheres + bovine collagen) produced greater wrinkle correction than collagen filler at 6 months and durable improvement to 4–5 years with low late adverse-event rates.
ArteFill (PMMA microspheres + bovine collagen) produced greater wrinkle correction than collagen filler at 6 months and durable improvement to 4–5 years with low late adverse-event rates.
ArteFill (PMMA microspheres + bovine collagen) produced greater wrinkle correction than collagen filler at 6 months and durable improvement to 4–5 years with low late adverse-event rates.
Daily 15 g specific collagen peptides plus 12-week resistance training increased fat-free mass and reduced fat mass more than placebo in overweight middle-aged men.
Sixty patients receiving either gelatin-sealed (Gelseal) or collagen-sealed (Hemashield) aortic grafts: gelatin group showed higher leukocyte counts in the second week, differences resolved by day 21.
Randomized comparison of femoral closure devices including AngioSeal (anchor + collagen sponge) showed no device-related differences in systemic inflammatory markers; IL-6 rose at 6 hours in all groups.
Using a collagen plug after catheterization shortened bleeding time and caused less pain with similar complication rates.
Five years of risedronate reduced bone turnover markers and increased lumbar spine BMD, with no pathologic biopsy findings.
Postmenopausal women received varying doses of ibandronate; higher doses increased BMD and reduced biochemical markers of bone turnover including type I collagen breakdown products.
Cross-linked collagen membranes persisted longer but had higher exposure rates; non-cross-linked membranes degraded faster and were often undetectable.
Cross-linked collagen membranes persisted longer but had higher exposure rates; non-cross-linked membranes degraded faster and were often undetectable.
Cross-linked collagen membranes persisted longer but had higher exposure rates; non-cross-linked membranes degraded faster and were often undetectable.
Antibody responses after using a bovine‑thrombin/collagen hemostat were similar to expected literature values and were not linked to adverse reactions.
Randomized multicenter study in patients with diabetic foot: adding Collost (collagen biomaterial) to standard therapy improved ulcer healing over 4 weeks.
Randomized multicenter study in patients with diabetic foot: adding Collost (collagen biomaterial) to standard therapy improved ulcer healing over 4 weeks.
Randomized trial of trapeziectomy with or without porcine collagen (Permacol) implant; collagen group had frequent adverse reactions and worse clinical outcomes.
Randomized trial of trapeziectomy with or without porcine collagen (Permacol) implant; collagen group had frequent adverse reactions and worse clinical outcomes.
Risedronate (daily or weekly) markedly lowered bone turnover markers (CTX and bone ALP) over 3–6 months in postmenopausal women with osteoporosis.
In dialysis patients with early secondary hyperparathyroidism, intermittent intravenous calcitriol prevented parathyroid gland enlargement compared with daily oral calcitriol over 12 months.
Double-blind randomized study in postmenopausal women: sublingual hormone therapy reduced bone turnover including type I collagen N-telopeptide and increased spine and hip BMD over 12 months.
Bazedoxifene/conjugated estrogens increased spine and hip bone mineral density and reduced bone turnover markers versus placebo in postmenopausal women at risk for osteoporosis.
Injecting collagen into masseter trigger points reduced pain and muscle activity more than lidocaine or saline over a 2-week observation.
Injecting collagen into masseter trigger points reduced pain and muscle activity more than lidocaine or saline over a 2-week observation.
Collagen injections (alone or with PRP) and PRP alone all improved pain and function over time, with no clear advantage of collagen over PRP or combined therapy at 24 weeks.
Collagen injections (alone or with PRP) and PRP alone all improved pain and function over time, with no clear advantage of collagen over PRP or combined therapy at 24 weeks.
Use of a gentamicin-containing collagen fleece with primary closure substantially shortened wound healing time versus open treatment.
Adding a gentamicin–collagen sponge to primary excision reduced early (1-week) postoperative complications but did not change long-term recurrence.
Use of a gentamicin-containing collagen fleece with primary closure substantially shortened wound healing time versus open treatment.
In this trial Contigen (bovine collagen-based injection) produced improvement in stress urinary incontinence, though Macroplastique outperformed it at 12 months.
In this trial Contigen (bovine collagen-based injection) produced improvement in stress urinary incontinence, though Macroplastique outperformed it at 12 months.
In this trial Contigen (bovine collagen-based injection) produced improvement in stress urinary incontinence, though Macroplastique outperformed it at 12 months.
In 50 elderly men, 6 months of raloxifene showed no overall change in bone turnover or lipids, but reductions in urinary type I collagen NTX occurred in a subset with low baseline estradiol.
Placing an Ologen collagen matrix with Ahmed glaucoma valve implantation lowered early postoperative IOP and reduced the hypertensive phase frequency but did not change long-term success rates.
Three ARP approaches (including use of collagen membrane) produced similar horizontal ridge preservation; some differences in vertical mid-crestal measurements and mucosal thickness were observed.
Three ARP approaches (including use of collagen membrane) produced similar horizontal ridge preservation; some differences in vertical mid-crestal measurements and mucosal thickness were observed.
Three ARP approaches (including use of collagen membrane) produced similar horizontal ridge preservation; some differences in vertical mid-crestal measurements and mucosal thickness were observed.
Applying gentamicin-collagen sponges or collagen-only sponges to the extraction-site wound did not significantly reduce 30-day surgical site infections compared with no sponge.
Applying gentamicin-collagen sponges or collagen-only sponges to the extraction-site wound did not significantly reduce 30-day surgical site infections compared with no sponge.
In a split-mouth RCT, xenogeneic collagen matrix (XCM) improved root coverage and quality of life but CTG produced greater final gingival thickness and slightly better root-coverage metrics at 18 months.
Atelocollagen injections for partial supraspinatus tears provided greater and more sustained pain relief and better MRI-documented structural improvement than prolotherapy at 3 months.
Atelocollagen injections for partial supraspinatus tears provided greater and more sustained pain relief and better MRI-documented structural improvement than prolotherapy at 3 months.
Adding a xenogeneic collagen matrix to coronally advanced flap increased gingival thickness but did not improve root coverage versus flap alone at 1 year.
Using two types of xenogeneic collagen matrices with bone graft helped maintain soft tissues and limited ridge resorption after tooth extraction, with small increases in gingival thickness.
Adding a xenogeneic collagen matrix to coronally advanced flap increased gingival thickness but did not improve root coverage versus flap alone at 1 year.
Adding a xenogeneic collagen matrix to coronally advanced flap surgery increased keratinized tissue width and gingival thickness vs flap alone, while root coverage and patient satisfaction were similar at 12 months.
Adding a xenogeneic collagen matrix to coronally advanced flap increased gingival thickness but did not improve root coverage versus flap alone at 1 year.
Intra-articular porcine-collagen product (MD-Knee) was non-inferior to sodium hyaluronate in improving function and pain in knee osteoarthritis up to 6 months.
Intra-articular porcine-collagen product (MD-Knee) was non-inferior to sodium hyaluronate in improving function and pain in knee osteoarthritis up to 6 months.
In patients with open-angle glaucoma, very deep sclerectomy with a collagen implant provided good IOP control similar to standard deep sclerectomy over 2 years, with lower day-1 IOP in the very deep method.
In a randomized multicenter trial, adding an Ologen collagen matrix to Ahmed valve surgery did not improve IOP control, medication need, hypertensive phase incidence, or 1-year success compared with standard surgery.
Collagen implants in deep sclerectomy produced intraocular pressure lowering and medication reduction comparable to a PMMA implant—no significant differences between implants.
In phacotrabeculectomy, the collagen matrix implant and mitomycin C produced similar intraocular pressure lowering and success rates at 12 months.
In 64 patients, equine-derived collagenated xenogeneic bone blocks were non-inferior to autogenous bone blocks for horizontal ridge augmentation, with less early post-op pain.
Putting a collagen sponge into extraction sockets reduced pain after wisdom tooth surgery and may slightly lower dry-socket rates.
Putting a collagen sponge into extraction sockets reduced pain after wisdom tooth surgery and may slightly lower dry-socket rates.
Putting a collagen sponge into extraction sockets reduced pain after wisdom tooth surgery and may slightly lower dry-socket rates.
Daylight photodynamic therapy with pretreatment CO2 laser improved clinical and histologic outcomes for photodamaged facial skin, including a significant increase in collagen type I and reduced solar elastosis.
In postmenopausal breast cancer patients, tamoxifen reduced markers of bone resorption and formation and increased spine and femoral BMD, whereas toremifene showed smaller effects.
Human collagen injections produced rapid improvement in nasolabial folds but the effect mostly disappeared by 13 months; PLLA showed longer-lasting improvement.
Human collagen injections produced rapid improvement in nasolabial folds but the effect mostly disappeared by 13 months; PLLA showed longer-lasting improvement.
Adding collagen augmentation to microfracture improved biopsy-based cartilage repair quality at 1 year but clinical pain/function scores did not differ.
Adding collagen augmentation to microfracture improved biopsy-based cartilage repair quality at 1 year but clinical pain/function scores did not differ.
Adding collagen augmentation to microfracture improved biopsy-based cartilage repair quality at 1 year but clinical pain/function scores did not differ.
In older inpatients, daily oral supplement with 10 g collagen peptides for 8 weeks increased forearm skin hydration and elasticity versus control.
Two single-center 28-day topical lotion studies (5% and 20% TBFE) in adults showed improved skin tone, reduced water loss, increased hydration and reduced wrinkles.
Resorbable collagen membrane produced similar augmented bone volumetric loss as platelet-rich fibrin at 6 months.
Resorbable collagen membrane produced similar augmented bone volumetric loss as platelet-rich fibrin at 6 months.
Compared polyglycolic acid (Neoveil) versus collagen sponge (TachoSil); Neoveil showed faster median air-leak closure and lower early air-loss AUC and lower PAL incidence, but differences were not statistically significant.
Compared polyglycolic acid (Neoveil) versus collagen sponge (TachoSil); Neoveil showed faster median air-leak closure and lower early air-loss AUC and lower PAL incidence, but differences were not statistically significant.
Compared polyglycolic acid (Neoveil) versus collagen sponge (TachoSil); Neoveil showed faster median air-leak closure and lower early air-loss AUC and lower PAL incidence, but differences were not statistically significant.
At 6 months there were no statistically significant differences in functional and symptomatic outcomes between autologous cartilage and bovine/porcine acellular dermal matrix spacer grafts.
At 6 months there were no statistically significant differences in functional and symptomatic outcomes between autologous cartilage and bovine/porcine acellular dermal matrix spacer grafts.
Eight-week double-blind RCT: hydrolysed collagen supplementation did not reduce android fat or increase nesfatin; the collagen group had a small BMI increase while whey reduced android fat and increased nesfatin.
Eight-week double-blind RCT: hydrolysed collagen supplementation did not reduce android fat or increase nesfatin; the collagen group had a small BMI increase while whey reduced android fat and increased nesfatin.
Eight-week double-blind RCT: hydrolysed collagen supplementation did not reduce android fat or increase nesfatin; the collagen group had a small BMI increase while whey reduced android fat and increased nesfatin.
Apligraf (a collagen-containing living skin substitute) applied over meshed autografts improved long-term cosmetic and functional wound outcomes versus control.
Apligraf (a collagen-containing living skin substitute) applied over meshed autografts improved long-term cosmetic and functional wound outcomes versus control.
Apligraf (a collagen-containing living skin substitute) applied over meshed autografts improved long-term cosmetic and functional wound outcomes versus control.
Twelve weeks of resistance training plus 15 g/day specific collagen peptides increased fat-free mass, reduced fat mass, and improved hand-grip strength more than placebo.
Twelve weeks of resistance training plus 15 g/day specific collagen peptides increased fat-free mass, reduced fat mass, and improved hand-grip strength more than placebo.
Daily willow bark (salicin) modestly reduced platelet aggregation compared with placebo but far less than aspirin; no effect on collagen-induced aggregation.
In healthy men, single IV doses of Revacept dose-dependently inhibited collagen-induced platelet aggregation without affecting bleeding time or general hemostasis.
Patterns of platelet inhibition differed by treatment; ER-DP+ASA caused later reductions in multiple platelet activation markers, while clopidogrel (with ASA) inhibited collagen-induced aggregation earlier.
In a double-blind crossover trial of elderly hypertensive patients, manidipine reduced thrombin/ADP- and collagen-induced platelet aggregation—particularly in those with type II diabetes—whereas atenolol did not.
A prospective controlled trial found a novel collagen-based hemostatic composite (CoStasis) achieved faster and more frequent rapid hemostasis than a collagen sponge after tumor resection.
The collagen-based CoStasis hemostat produced higher hemostatic success and much faster bleeding control than standard manual compression across multiple surgical specialties.
A prospective controlled trial found a novel collagen-based hemostatic composite (CoStasis) achieved faster and more frequent rapid hemostasis than a collagen sponge after tumor resection.
In damaged tooth sockets grafted and covered with a collagen membrane, both bovine and porcine deproteinized bone produced similar amounts of new bone and residual material after 4 months.
Randomized clinical trial comparing flapped vs flapless socket grafting with porcine bone and collagen membrane found similar histological outcomes after 3 months.
In damaged tooth sockets grafted and covered with a collagen membrane, both bovine and porcine deproteinized bone produced similar amounts of new bone and residual material after 4 months.
In damaged tooth sockets grafted and covered with a collagen membrane, both bovine and porcine deproteinized bone produced similar amounts of new bone and residual material after 4 months.
Adding PMMA-collagen gel injections after microneedling produced greater improvement in atrophic acne scars at 24 and 36 weeks compared with microneedling alone.
The biodegradable collagen implant (Ologen) provided similar long-term intraocular pressure control to mitomycin-C, with higher bleb height and no observed adverse reaction.
Compared two xenograft ridge-preservation protocols in humans; the protocol using a cross-linked bovine collagen sponge produced more vital bone than the other, while clinical dimensional changes were similar.
Pilot RCT (27 patients) comparing PRF membrane vs standard graft coverage with deproteinized bovine bone and a resorbable collagen membrane; both showed similarly low bone vitality at 6 months.
Pilot RCT (27 patients) comparing PRF membrane vs standard graft coverage with deproteinized bovine bone and a resorbable collagen membrane; both showed similarly low bone vitality at 6 months.
Randomized trial (30 participants) showing argon plasma-treated abutments reduced plaque/inflammation and increased connective tissue healing and collagen content at 2 months.
Randomized trial (30 participants) showing argon plasma-treated abutments reduced plaque/inflammation and increased connective tissue healing and collagen content at 2 months.
Prospective comparative clinical study comparing two accelerated corneal collagen cross-linking radiances (5.4 vs 7.2 J/cm2) showing similar visual and topographic outcomes at 12 months.
In 50 patients with bilateral progressive keratoconus, continuous and pulsed accelerated corneal collagen cross-linking with supplemental oxygen produced comparable improvements in corneal topography and biomechanics at one year.
Prospective comparative clinical study comparing two accelerated corneal collagen cross-linking radiances (5.4 vs 7.2 J/cm2) showing similar visual and topographic outcomes at 12 months.
Postmenopausal women received varying doses of ibandronate; higher doses increased BMD and reduced biochemical markers of bone turnover including type I collagen breakdown products.
Large randomized trial: adding collagen-gentamicin sponges during sternotomy closure halved sternal wound infection rates.
In cardiac surgery patients, adding collagen–gentamicin sponges to standard prophylaxis halved sternal wound infection rates (4.3% vs 9.0%) but increased early reoperation for bleeding.
Large randomized trial: adding collagen-gentamicin sponges during sternotomy closure halved sternal wound infection rates.
Multicenter RCT found Promogran (collagen/ORC) produced numerically more healed diabetic foot ulcers overall and in recent ulcers, but primary outcome was not statistically significant.
Multicenter RCT found Promogran (collagen/ORC) produced numerically more healed diabetic foot ulcers overall and in recent ulcers, but primary outcome was not statistically significant.
Randomised trial comparing ARP techniques found that groups using bone graft plus collagen sponge or free gingival graft had less vertical and horizontal bone resorption than graftless treatment after 4 months.
Randomised trial comparing ARP techniques found that groups using bone graft plus collagen sponge or free gingival graft had less vertical and horizontal bone resorption than graftless treatment after 4 months.
Using a resorbable collagen membrane did not reduce horizontal bone resorption; piezosurgery showed no clinical advantage over rotative instruments and took longer.
Intermittent senolytic therapy did not reduce overall bone resorption but transiently increased a bone formation marker and showed benefit in a high-senescent-burden subgroup.
Randomized double-blind trial in women >60: yogurt fortified with vitamin D3 (400 IU) and additional calcium increased 25OHD and decreased PTH and bone resorption markers over 12 weeks.
Randomized double-blind trial in thalassemia patients: weekly alendronate for 12 months increased lumbar (L1–L4) BMD and reduced bone turnover markers versus placebo.
Randomized double-blind trial comparing isolated bioinductive repair (implant that induces collagen deposition) versus sutured repair for small/medium full-thickness rotator cuff tears: bioinductive repair yielded superior collagen organization, greater tendon thickness increase, 100% MRI healing at 12/24 months, better PROs and faster return to work.
Randomized trial comparing coronally advanced flap with or without xenogenous collagen matrix and/or enamel matrix derivative for gingival recession; patients reported less dentin sensitivity and improved esthetics and oral-health quality of life after 6 months.
Randomized trial comparing coronally advanced flap with or without xenogenous collagen matrix and/or enamel matrix derivative for gingival recession; patients reported less dentin sensitivity and improved esthetics and oral-health quality of life after 6 months.
Randomized trial comparing coronally advanced flap with or without xenogenous collagen matrix and/or enamel matrix derivative for gingival recession; patients reported less dentin sensitivity and improved esthetics and oral-health quality of life after 6 months.
Randomized trial of percutaneous collagen plug implantation vs conventional haemostasis after coronary procedures showed dramatic reduction in manual compression time but increased access-site complications (notably after PTCA).
Randomized trial of percutaneous collagen plug implantation vs conventional haemostasis after coronary procedures showed dramatic reduction in manual compression time but increased access-site complications (notably after PTCA).
Randomized trial of percutaneous collagen plug implantation vs conventional haemostasis after coronary procedures showed dramatic reduction in manual compression time but increased access-site complications (notably after PTCA).
In patients with diabetic foot ulcers, local collagen dressings reduced wound area and depth more than standard care and similarly to NPWT.
In a small double‑blind RCT, multispectral LED treatment did not show overall superiority vs sham for grade‑2 sacral pressure ulcers; LED increased epidermal thickness and basement membrane measures but wound area changes were similar.
In patients with diabetic foot ulcers, local collagen dressings reduced wound area and depth more than standard care and similarly to NPWT.
In patients with diabetic foot ulcers, local collagen dressings reduced wound area and depth more than standard care and similarly to NPWT.
Self-controlled randomized trial in bilateral TKA: adding mineralized (recombinant) collagen to PMMA cement was safe and produced a small short-term functional advantage (better KS function score at 1 year) but otherwise comparable outcomes to standard PMMA.
Self-controlled randomized trial in bilateral TKA: adding mineralized (recombinant) collagen to PMMA cement was safe and produced a small short-term functional advantage (better KS function score at 1 year) but otherwise comparable outcomes to standard PMMA.
Self-controlled randomized trial in bilateral TKA: adding mineralized (recombinant) collagen to PMMA cement was safe and produced a small short-term functional advantage (better KS function score at 1 year) but otherwise comparable outcomes to standard PMMA.
Biomarker subanalysis in CRT recipients found that lower baseline PIIINP (a collagen turnover marker) predicted favorable echocardiographic response and lower long-term mortality/MACE risk.
Biomarker subanalysis in CRT recipients found that lower baseline PIIINP (a collagen turnover marker) predicted favorable echocardiographic response and lower long-term mortality/MACE risk.
Biomarker subanalysis in CRT recipients found that lower baseline PIIINP (a collagen turnover marker) predicted favorable echocardiographic response and lower long-term mortality/MACE risk.
Topical estradiol or genistein applied to facial skin of postmenopausal women for 24 weeks increased type I and III collagen; estradiol produced a larger increase.
Topical estradiol or genistein applied to facial skin of postmenopausal women for 24 weeks increased type I and III collagen; estradiol produced a larger increase.
Topical estradiol or genistein applied to facial skin of postmenopausal women for 24 weeks increased type I and III collagen; estradiol produced a larger increase.
In children undergoing secondary alveolar bone grafting, using a collagen membrane as an interpositional layer improved bone formation and density versus no membrane, similar to platelet-rich fibrin.
In children undergoing secondary alveolar bone grafting, using a collagen membrane as an interpositional layer improved bone formation and density versus no membrane, similar to platelet-rich fibrin.
In patients with progressive bilateral keratoconus, corneal collagen cross-linking of one eye halted progression and in many eyes improved topography and vision over 18 months compared with the untreated fellow eye.
In patients with progressive bilateral keratoconus, corneal collagen cross-linking of one eye halted progression and in many eyes improved topography and vision over 18 months compared with the untreated fellow eye.
Corneal collagen cross-linking stabilized progressive keratoconus and reduced corneal steepness over 12 months.
In patients with progressive bilateral keratoconus, corneal collagen cross-linking of one eye halted progression and in many eyes improved topography and vision over 18 months compared with the untreated fellow eye.
In this pilot RCT, collagen hydrolysate supplementation produced region-specific increases in dGEMRIC T1 (suggesting increased proteoglycan) in medial and lateral tibial cartilage at 24 weeks versus declines with placebo; no other MRI, clinical, or T2 changes were seen.
In this pilot RCT, collagen hydrolysate supplementation produced region-specific increases in dGEMRIC T1 (suggesting increased proteoglycan) in medial and lateral tibial cartilage at 24 weeks versus declines with placebo; no other MRI, clinical, or T2 changes were seen.
In this pilot RCT, collagen hydrolysate supplementation produced region-specific increases in dGEMRIC T1 (suggesting increased proteoglycan) in medial and lateral tibial cartilage at 24 weeks versus declines with placebo; no other MRI, clinical, or T2 changes were seen.
In randomized carotid endarterectomy, collagen-impregnated Dacron (Hemashield) patching was associated with higher perioperative stroke, thrombosis, and early restenosis rates compared with PTFE, but had shorter hemostasis time.
In randomized carotid endarterectomy, collagen-impregnated Dacron (Hemashield) patching was associated with higher perioperative stroke, thrombosis, and early restenosis rates compared with PTFE, but had shorter hemostasis time.
In randomized carotid endarterectomy, collagen-impregnated Dacron (Hemashield) patching was associated with higher perioperative stroke, thrombosis, and early restenosis rates compared with PTFE, but had shorter hemostasis time.
Use of a fibrinogen/coagulation-factor coated collagen patch (TachoSil) at lymphadenectomy sites was associated with lower drainage volume and fewer lymphoceles compared with historical controls.
Collagen hemostatic sponge reduced postoperative bleeding, transfusions, and hospital stay versus gelatin sponge; topical TXA reduced bleeding more than collagen.
Double‑blind RCT testing a topical collagen/thrombin/autologous platelet haemostatic agent in primary cementless THA to reduce transfusions and blood loss.
Double‑blind RCT testing a topical collagen/thrombin/autologous platelet haemostatic agent in primary cementless THA to reduce transfusions and blood loss.
Randomized trial comparing ridge preservation with non‑crosslinked collagen membrane (submerged) versus crosslinked collagen membrane left exposed plus allograft; assessed soft and hard tissue dimensional outcomes at 6 months.
Randomized trial comparing ridge preservation with non‑crosslinked collagen membrane (submerged) versus crosslinked collagen membrane left exposed plus allograft; assessed soft and hard tissue dimensional outcomes at 6 months.
Randomized trial comparing ridge preservation with non‑crosslinked collagen membrane (submerged) versus crosslinked collagen membrane left exposed plus allograft; assessed soft and hard tissue dimensional outcomes at 6 months.
Small randomized double‑blind placebo‑controlled trial of an oral fish‑derived collagen peptide plus ornithine drink given nightly for 8 weeks in adults with low skin moisture/elasticity, measuring skin elasticity, TEWL, pores, and IGF‑1.
Small randomized double‑blind placebo‑controlled trial of an oral fish‑derived collagen peptide plus ornithine drink given nightly for 8 weeks in adults with low skin moisture/elasticity, measuring skin elasticity, TEWL, pores, and IGF‑1.
Bovine collagen injections provided temporary wrinkle correction but were less durable and required more volume than hyaluronic acid; side-effect profiles were similar.
Higher baseline serum NTx (a bone collagen breakdown marker) was associated with shorter clinical benefit duration, shorter time to progression, and shorter overall survival.
Higher baseline serum NTx (a bone collagen breakdown marker) was associated with shorter clinical benefit duration, shorter time to progression, and shorter overall survival.
Higher baseline serum NTx (a bone collagen breakdown marker) was associated with shorter clinical benefit duration, shorter time to progression, and shorter overall survival.
Single‑center randomized trial: placing a gentamicin‑collagen implant in the pelvis at surgery was associated with a lower 5‑year cumulative incidence of distant metastases versus control.
Adding cyanoacrylate over a hemostatic collagen sponge on palatal donor sites reduced postoperative pain and analgesic use after graft harvesting.
Adding cyanoacrylate over a hemostatic collagen sponge on palatal donor sites reduced postoperative pain and analgesic use after graft harvesting.
Daily willow bark (salicin) modestly reduced platelet aggregation compared with placebo but far less than aspirin; no effect on collagen-induced aggregation.
Adding clopidogrel to aspirin significantly reduced multiple measures of platelet activation versus aspirin alone in heart failure patients with heightened platelet activity.
Using donor corneas pretreated with corneal collagen cross-linking led to better visual acuity and less myopia/astigmatism after penetrating keratoplasty over 3 years.
Prospective randomized study comparing CXL protocols in 138 keratoconus patients found significant improvements in visual and refractive outcomes for several accelerated and conventional protocols at 12 months, with some protocols performing better than others.
Prospective randomized study comparing CXL protocols in 138 keratoconus patients found significant improvements in visual and refractive outcomes for several accelerated and conventional protocols at 12 months, with some protocols performing better than others.
Multi-center analysis of 59 Class II furcation pairs found bioabsorbable collagen membrane improved vertical defect fill, percent defect resolution, and horizontal furcation fill versus debridement and performed similarly to ePTFE.
Multi-center analysis of 59 Class II furcation pairs found bioabsorbable collagen membrane improved vertical defect fill, percent defect resolution, and horizontal furcation fill versus debridement and performed similarly to ePTFE.
Multi-center analysis of 59 Class II furcation pairs found bioabsorbable collagen membrane improved vertical defect fill, percent defect resolution, and horizontal furcation fill versus debridement and performed similarly to ePTFE.
Randomized comparative study of 60 patients found that combining hyaluronic acid with collagen reduced the Tyndall effect and that differences in aesthetic/tear trough scores emerged by 3 months between groups.
Randomized comparative study of 60 patients found that combining hyaluronic acid with collagen reduced the Tyndall effect and that differences in aesthetic/tear trough scores emerged by 3 months between groups.
Randomized comparative study of 60 patients found that combining hyaluronic acid with collagen reduced the Tyndall effect and that differences in aesthetic/tear trough scores emerged by 3 months between groups.
Adding a collagen membrane plus bone mineral resulted in more radiographic bone fill but no differences in clinical signs or patient-reported outcomes at 12 months.
Filling extraction/implant defects with a hydroxyapatite–collagen material led to more implant sites covered by new bone-like tissue than leaving defects empty.
Filling extraction/implant defects with a hydroxyapatite–collagen material led to more implant sites covered by new bone-like tissue than leaving defects empty.
A collagen-based dermal template increased complete wound closure rates and sped healing compared with standard care in chronic diabetic foot ulcers.
A collagen-based dermal template increased complete wound closure rates and sped healing compared with standard care in chronic diabetic foot ulcers.
A collagen-based dermal template increased complete wound closure rates and sped healing compared with standard care in chronic diabetic foot ulcers.
Randomized feeding study: the DASH diet lowered bone turnover markers and sodium reduction decreased calcium excretion and some bone markers; vitamin D was discussed but not tested.
12-week randomized dietary supplement trial in adults with abdominal obesity; whey protein increased urinary calcium but did not change bone turnover markers or BMD.
Post-hoc analysis of a multicenter randomized trial comparing a collagen gel versus hydrogel for urethral injection showed overall rates of cure/improvement at 1 year and identified patient factors linked to success.
Post-hoc analysis of a multicenter randomized trial comparing a collagen gel versus hydrogel for urethral injection showed overall rates of cure/improvement at 1 year and identified patient factors linked to success.
Post-hoc analysis of a multicenter randomized trial comparing a collagen gel versus hydrogel for urethral injection showed overall rates of cure/improvement at 1 year and identified patient factors linked to success.
Randomized trial in diabetic foot ulcers compared oxidized regenerated cellulose/collagen dressing, autologous growth factors, and their combination over 8 weeks.
Randomized clinical trial evaluated histologic and imaging outcomes at 3, 6, and 9 months after socket preservation with deproteinized bovine bone mineral with collagen and a porcine collagen matrix.
Randomized clinical trial evaluated histologic and imaging outcomes at 3, 6, and 9 months after socket preservation with deproteinized bovine bone mineral with collagen and a porcine collagen matrix.
Randomized clinical trial evaluated histologic and imaging outcomes at 3, 6, and 9 months after socket preservation with deproteinized bovine bone mineral with collagen and a porcine collagen matrix.
Adding deproteinized bovine bone with collagen during immediate dental implant placement improved soft tissue height and buccolingual ridge width vs implant alone.
Adding deproteinized bovine bone with collagen during immediate dental implant placement improved soft tissue height and buccolingual ridge width vs implant alone.
Using donor corneas pretreated with corneal collagen cross-linking led to better visual acuity and less myopia/astigmatism after penetrating keratoplasty over 3 years.
Placing an Ologen collagen matrix with Ahmed glaucoma valve implantation lowered early postoperative IOP and reduced the hypertensive phase frequency but did not change long-term success rates.
Compared a synthetic bone sealant to a collagen fleece for stopping bleeding after iliac crest bone harvesting; both were safe and had similar wound-healing.
Compared a synthetic bone sealant to a collagen fleece for stopping bleeding after iliac crest bone harvesting; both were safe and had similar wound-healing.
Compared a synthetic bone sealant to a collagen fleece for stopping bleeding after iliac crest bone harvesting; both were safe and had similar wound-healing.
Randomized trial in patients with bone defects: porous hydroxyapatite/collagen implant produced superior radiographic bone regeneration versus porous β-TCP by 18–24 weeks, with more (non-serious) adverse events.
Compared acellular dermal graft (collagen-containing) to silastic implants for empty nose syndrome; both groups showed marked symptom improvement.
Oral chicken collagen hydrolysate (2.9 g/day) for 18 weeks reduced arterial stiffness and blood pressure and increased serum nitric oxide versus placebo.
Oral chicken collagen hydrolysate (2.9 g/day) for 18 weeks reduced arterial stiffness and blood pressure and increased serum nitric oxide versus placebo.
Oral chicken collagen hydrolysate (2.9 g/day) for 18 weeks reduced arterial stiffness and blood pressure and increased serum nitric oxide versus placebo.
GH dosing altered bone density and increased biochemical collagen markers over 12 months in adults with GH deficiency.
GH dosing altered bone density and increased biochemical collagen markers over 12 months in adults with GH deficiency.
GH dosing altered bone density and increased biochemical collagen markers over 12 months in adults with GH deficiency.
Daily fish-derived collagen peptides for 12 weeks lowered skin/vessel AGEs and slightly improved insulin resistance versus placebo.
Daily fish-derived collagen peptides for 12 weeks lowered skin/vessel AGEs and slightly improved insulin resistance versus placebo.
Daily fish-derived collagen peptides for 12 weeks lowered skin/vessel AGEs and slightly improved insulin resistance versus placebo.
Collagen plug (VasoSeal) markedly shortened time to hemostasis after PTCA versus manual compression, with similar overall local complication rates.
Collagen plug (VasoSeal) markedly shortened time to hemostasis after PTCA versus manual compression, with similar overall local complication rates.
Bio-Oss Collagen placed into extraction sockets produced earlier-stage bone formation and denser tissue allowing implant placement after eight weeks.
Bio-Oss Collagen placed into extraction sockets produced earlier-stage bone formation and denser tissue allowing implant placement after eight weeks.
Bio-Oss Collagen placed into extraction sockets produced earlier-stage bone formation and denser tissue allowing implant placement after eight weeks.
Alendronate reduced pain and improved pain-related quality of life and increased lumbar BMD more than alfacalcidol in postmenopausal osteoporotic women.
Randomized trial in chronic diabetic foot ulcers: a porcine-derived purified reconstituted bilayer matrix (ECM product) produced higher 12-week healing rates, faster healing, and much greater wound area reduction than standard collagen-alginate dressing.
Porcine acellular dermal (Strattice™) mesh gave similar early complication and 3-month pain scores to synthetic mesh, with less immediate postoperative pain days 1–3.
Porcine acellular dermal (Strattice™) mesh gave similar early complication and 3-month pain scores to synthetic mesh, with less immediate postoperative pain days 1–3.
Porcine acellular dermal (Strattice™) mesh gave similar early complication and 3-month pain scores to synthetic mesh, with less immediate postoperative pain days 1–3.
ORC/collagen matrix applied to pressure sores accelerated healing and reduced protease (elastase and plasmin) activity in wound exudate versus foam dressing control.
ORC/collagen matrix applied to pressure sores accelerated healing and reduced protease (elastase and plasmin) activity in wound exudate versus foam dressing control.
Adjunctive collagen+alginate dressing with compression increased granulation tissue and reduced ulcer area more than alginate alone over 12 weeks.
Adjunctive collagen+alginate dressing with compression increased granulation tissue and reduced ulcer area more than alginate alone over 12 weeks.
Adjunctive collagen+alginate dressing with compression increased granulation tissue and reduced ulcer area more than alginate alone over 12 weeks.
Randomised double-blind study comparing porcine/bovine collagen fillers and hyaluronic acid for upper lip wrinkles; all treatments increased lip volume and reduced wrinkles, Perlane showed greatest and most sustained volume.
Porcine-derived collagen matrix (PDCM) produced better root coverage and less pain/time than connective tissue grafts in smokers.
Randomised comparison in high-bleeding-risk cardiac surgery showing microfibrillar collagen powder (Colgel) substantially reduced early and total postoperative chest drainage versus Surgicel.
Randomised comparison in high-bleeding-risk cardiac surgery showing microfibrillar collagen powder (Colgel) substantially reduced early and total postoperative chest drainage versus Surgicel.
Randomised comparison in high-bleeding-risk cardiac surgery showing microfibrillar collagen powder (Colgel) substantially reduced early and total postoperative chest drainage versus Surgicel.
Randomised trial showing primary closure with collagen‑gentamicin implant reduced surgical wound infections and shortened healing time versus open wound care in contaminated abdominal wounds.
Randomised trial showing primary closure with collagen‑gentamicin implant reduced surgical wound infections and shortened healing time versus open wound care in contaminated abdominal wounds.
Randomised trial comparing ARP techniques found that groups using bone graft plus collagen sponge or free gingival graft had less vertical and horizontal bone resorption than graftless treatment after 4 months.
Collagen cross-linking provided short-term symptomatic relief, reduced central corneal thickness and caused anterior stromal compaction in PBK patients.
Corneal collagen cross-linking improved vision and reduced corneal curvature at 6 months versus sham, with expected cellular changes on confocal microscopy.
Accelerated and standard corneal collagen crosslinking produced similar 6-month outcomes for keratoconus (visual acuity, refraction, topography); central corneal thickness was higher in the standard group.
Corneal collagen cross-linking stabilized progressive keratoconus and reduced corneal steepness over 12 months.
Contralateral randomized trial in Down syndrome patients with keratoconus comparing standard vs accelerated corneal cross-linking over 3 years; both flattened corneas similarly but standard better preserved corneal stiffness.
Contralateral randomized trial in Down syndrome patients with keratoconus comparing standard vs accelerated corneal cross-linking over 3 years; both flattened corneas similarly but standard better preserved corneal stiffness.
Contralateral randomized trial in Down syndrome patients with keratoconus comparing standard vs accelerated corneal cross-linking over 3 years; both flattened corneas similarly but standard better preserved corneal stiffness.
In older adults under energy restriction and reduced activity, collagen peptides did not prevent leg muscle loss or restore muscle protein synthesis during recovery; whey protein did restore these measures.
In older adults under energy restriction and reduced activity, collagen peptides did not prevent leg muscle loss or restore muscle protein synthesis during recovery; whey protein did restore these measures.
Pivotal randomized FDA IDE trial comparing i-Factor (P‑15 synthetic collagen fragment bone graft) versus local autograft in single-level anterior cervical fusion with 2-year follow-up; similar clinical outcomes and fusion rates, with a higher composite overall success for i-Factor.
A randomized multicenter FDA IDE trial found the i-Factor bone graft (contains a synthetic collagen fragment P-15) noninferior to autograft for single-level ACDF with high fusion rates and similar safety; overall composite success was higher with i-Factor.
MIV-711 did not improve pain but significantly reduced bone area progression, reduced cartilage thinning, and lowered collagen biomarker levels.
Adding a gentamicin‑collagen implant (Gentacoll) to clindamycin did not reduce abscess/fistula recurrence compared with clindamycin alone.
Smokers had smaller, more superficial punch wounds and lower vitamin C and PINP (a collagen synthesis marker); smoking cessation increased wound depth, vitamin C, and PINP; nicotine patch had no detectable effect.
Smokers had smaller, more superficial punch wounds and lower vitamin C and PINP (a collagen synthesis marker); smoking cessation increased wound depth, vitamin C, and PINP; nicotine patch had no detectable effect.
Smokers had smaller, more superficial punch wounds and lower vitamin C and PINP (a collagen synthesis marker); smoking cessation increased wound depth, vitamin C, and PINP; nicotine patch had no detectable effect.
Daily oral nutricosmeceutical (collagen peptides + antioxidants) for 90 days improved skin elasticity and texture versus placebo.
Daily oral nutricosmeceutical (collagen peptides + antioxidants) for 90 days improved skin elasticity and texture versus placebo.
In adults needing tooth extraction, DBBMC+native bilayer collagen membrane preserved more horizontal ridge width and healed with smaller incision gaps than DFDBA+cross-linked collagen after 6 months.
In adults needing tooth extraction, DBBMC+native bilayer collagen membrane preserved more horizontal ridge width and healed with smaller incision gaps than DFDBA+cross-linked collagen after 6 months.
In adults needing tooth extraction, DBBMC+native bilayer collagen membrane preserved more horizontal ridge width and healed with smaller incision gaps than DFDBA+cross-linked collagen after 6 months.
Human (injectable) collagen produced early improvement in nasolabial folds that largely wore off by 13 months, whereas poly-L-lactic acid maintained improvement much longer.
Human (injectable) collagen produced early improvement in nasolabial folds that largely wore off by 13 months, whereas poly-L-lactic acid maintained improvement much longer.
At 16 weeks, the hydroxyapatite–sugar cross-linked porcine collagen matrix group showed more vital bone formation than the bovine-derived xenograft+collagen matrix group; ridge dimensions were similar.
At 16 weeks, the hydroxyapatite–sugar cross-linked porcine collagen matrix group showed more vital bone formation than the bovine-derived xenograft+collagen matrix group; ridge dimensions were similar.
Split-mouth randomized trial comparing rhPDGF-BB + beta-TCP + bioabsorbable collagen dressing versus connective tissue graft for gingival recession; both improved clinically, with some measures favoring CTG and others favoring the test.
Corneal collagen cross-linking stabilized progressive keratoconus and reduced corneal steepness over 12 months.
Daily C. rabens extract (180 mg) for 4 weeks improved several skin-aging measures including reduced wrinkles and increased collagen-associated parameters compared with placebo.
Submucosal collagen injection (Permacol®) produced small improvement in incontinence but was markedly less effective than sacral neuromodulation at 6 months.
Submucosal collagen injection (Permacol®) produced small improvement in incontinence but was markedly less effective than sacral neuromodulation at 6 months.
Submucosal collagen injection (Permacol®) produced small improvement in incontinence but was markedly less effective than sacral neuromodulation at 6 months.
Use of a bovine bone graft plus a bioabsorbable collagen barrier led to greater soft- and hard-tissue improvement than open-flap debridement over the study period.
Adding autogenous bone (with or without bioactive glass) to a collagen membrane led to greater periodontal defect healing than collagen membrane alone.
A novel non-cross-linked collagen membrane (CXP) showed similar clinical performance to a reference membrane for guided bone regeneration at implant sites up to 1 year.
A novel non-cross-linked collagen membrane (CXP) showed similar clinical performance to a reference membrane for guided bone regeneration at implant sites up to 1 year.
Use of a collagen matrix implant in trabeculectomy produced similar IOP-lowering efficacy to mitomycin-C but a significantly lower risk of sustained hypotony.
Use of a collagen matrix implant in trabeculectomy produced similar IOP-lowering efficacy to mitomycin-C but a significantly lower risk of sustained hypotony.
In patients starting glucocorticoids, alfacalcidol (a vitamin D analog) increased some bone formation markers but BMD fell with alfacalcidol while it increased with alendronate over 18 months.
In ridge preservation, both collagen barrier types allowed some soft-tissue contour loss; the collagen matrix seal showed slightly less loss than the collagen sponge but differences were not statistically significant.
In ridge preservation, both collagen barrier types allowed some soft-tissue contour loss; the collagen matrix seal showed slightly less loss than the collagen sponge but differences were not statistically significant.
In ridge preservation, both collagen barrier types allowed some soft-tissue contour loss; the collagen matrix seal showed slightly less loss than the collagen sponge but differences were not statistically significant.
Adding collagen peptides to calcium + vitamin D for 12 months increased trabecular bone mass and vBMD at the tibia, prevented spine aBMD decline, and reduced bone turnover versus calcium + vitamin D alone.
Adding collagen peptides to calcium + vitamin D for 12 months increased trabecular bone mass and vBMD at the tibia, prevented spine aBMD decline, and reduced bone turnover versus calcium + vitamin D alone.
Adding collagen peptides to calcium + vitamin D for 12 months increased trabecular bone mass and vBMD at the tibia, prevented spine aBMD decline, and reduced bone turnover versus calcium + vitamin D alone.
Epithelium-off CXL produced greater flattening of maximum keratometry at 24 months than transepithelial CXL, with no significant difference in corrected visual acuity.
Corneal collagen cross-linking halted progression of keratoconus over 3 years, flattening Kmax and improving visual acuity compared with controls.
Epithelium-off CXL produced greater flattening of maximum keratometry at 24 months than transepithelial CXL, with no significant difference in corrected visual acuity.
Split-mouth randomized study in 40 patients comparing scaling/root planing alone versus adjunctive collagen-based tetracycline fibers for chronic periodontitis over 3 months.
Collagen membranes (native vs ribosome-crosslinked) gave similar clinical improvements in periodontal defect regeneration at 6 months.
Topical product containing collagen tripeptide improved objective skin barrier measures and reduced symptoms of sensitive atopic skin versus placebo over 4 weeks.
Double-blind randomized trial of tretinoin 0.05% lotion vs vehicle (vehicle contained soluble collagen among other hydrators) for chest photorejuvenation; both active and vehicle groups improved similarly by 180 days with mild, transient erythema higher in active at day 90.
RCT comparing ADM with vs without basement membrane in immediate prepectoral breast reconstruction: no significant differences in overall complications or shape change; seromas more frequent with basement membrane (10% vs 0%).
Randomized trial comparing two acellular dermal matrices (used as collagen-containing grafts) in staged breast reconstruction; similar complication rates but AlloDerm allowed faster expansion.
Randomized trial comparing two acellular dermal matrices (used as collagen-containing grafts) in staged breast reconstruction; similar complication rates but AlloDerm allowed faster expansion.
Randomized trial comparing two acellular dermal matrices (used as collagen-containing grafts) in staged breast reconstruction; similar complication rates but AlloDerm allowed faster expansion.
Prospective study showing modest flattening of maximum keratometry and regularization of epithelial thickness profile 6 months after epithelium-off CXL.
Pulsed accelerated corneal cross-linking produced a deeper stromal demarcation line than continuous accelerated CXL at 3 months.
Adding allograft plus collagen membrane increased labial bone regeneration at 1 year compared with surgery alone.
Adding allograft plus collagen membrane increased labial bone regeneration at 1 year compared with surgery alone.
Adding allograft plus collagen membrane increased labial bone regeneration at 1 year compared with surgery alone.
Both treatments increased tissue thickness, but connective tissue graft gave greater thickness gain while the collagen matrix resulted in less pain, shorter chair time, and higher satisfaction.
Both treatments increased tissue thickness, but connective tissue graft gave greater thickness gain while the collagen matrix resulted in less pain, shorter chair time, and higher satisfaction.
Both treatments increased tissue thickness, but connective tissue graft gave greater thickness gain while the collagen matrix resulted in less pain, shorter chair time, and higher satisfaction.
Daily willow bark (salicin) modestly reduced platelet aggregation compared with placebo but far less than aspirin; no effect on collagen-induced aggregation.
Randomized substudy comparing tamoxifen, exemestane, and anastrozole over 2 years; tamoxifen was associated with lower bone turnover markers (NTX and BAP) versus the two aromatase inhibitors, with BMD trends favoring tamoxifen though not always significant.
IV zoledronic acid after ACDF shortened time to osteogenesis, promoted fusion, lowered a collagen degradation marker (CTX) and increased lumbar spine BMD, with improved neck disability scores.
Randomized placebo-controlled trial of 50 mg DHEA daily for 1 year showing hormonal changes and modest bone benefits in women but not men.
Using a collagen matrix gave good root coverage but resulted in less complete coverage than connective tissue grafts at 6 months.
Using a collagen matrix gave good root coverage but resulted in less complete coverage than connective tissue grafts at 6 months.
Using a collagen matrix gave good root coverage but resulted in less complete coverage than connective tissue grafts at 6 months.
In post-MI patients, eplerenone lowered a blood marker of collagen turnover (PIIINP) when baseline levels were high.
In mild-moderate heart failure, spironolactone lowered BNP and a blood marker of collagen turnover (PIIINP) but worsened renal function and self-reported quality of life over 3 months.
Randomized study comparing a synthetic PEG hydrogel membrane vs standard collagen membrane for guided bone regeneration around implants; regenerated bone was similar and both membranes performed comparably after 6 months.
Randomized feeding study: the DASH diet lowered bone turnover markers and sodium reduction decreased calcium excretion and some bone markers; vitamin D was discussed but not tested.
PLLA injections (a collagen-stimulating filler) reduced stretch-mark area and volume and increased type III collagen without notable inflammation.
PLLA injections (a collagen-stimulating filler) reduced stretch-mark area and volume and increased type III collagen without notable inflammation.
PLLA injections (a collagen-stimulating filler) reduced stretch-mark area and volume and increased type III collagen without notable inflammation.
In healthy adults, 8 weeks of high-dose simvastatin (80 mg/day) lowered a serum bone formation marker but did not change a urinary collagen resorption marker.
Collagen plug repair had a substantially higher fistula recurrence rate than advancement flap at 12 months; pain improved in both groups.
Collagen plug repair had a substantially higher fistula recurrence rate than advancement flap at 12 months; pain improved in both groups.
Collagen plug repair had a substantially higher fistula recurrence rate than advancement flap at 12 months; pain improved in both groups.
Losartan prevented increases in ultrasonic fibrosis signal seen with other agents and reduced a serum marker ratio consistent with decreased type I collagen turnover.
Losartan prevented increases in ultrasonic fibrosis signal seen with other agents and reduced a serum marker ratio consistent with decreased type I collagen turnover.
Losartan prevented increases in ultrasonic fibrosis signal seen with other agents and reduced a serum marker ratio consistent with decreased type I collagen turnover.
Randomized double-blind trial in postmenopausal women showed risedronate (daily or once-weekly) strongly reduced bone formation and resorption markers over 6 months.
Risedronate (daily or weekly) markedly lowered bone turnover markers (CTX and bone ALP) over 3–6 months in postmenopausal women with osteoporosis.
In elderly osteoporotic women, alendronate increased lumbar BMD and reduced bone resorption more than etidronate; both treatments reduced back pain.
Alendronate reduced pain and improved pain-related quality of life and increased lumbar BMD more than alfacalcidol in postmenopausal osteoporotic women.
Compared CaHA vs bovine dermal collagen injections for female stress urinary incontinence; both tolerated and showed improvement at 12 months.
Compared CaHA vs bovine dermal collagen injections for female stress urinary incontinence; both tolerated and showed improvement at 12 months.
Compared CaHA vs bovine dermal collagen injections for female stress urinary incontinence; both tolerated and showed improvement at 12 months.
Daily high-calcium mineral water (596 mg Ca) for 6 months lowered PTH and multiple bone turnover markers; adding 400 IU vitamin D provided no additional reduction.
Randomized trial comparing xenogenic collagen matrix vs connective tissue graft for gingival recession over 36 months; collagen matrix provided less root coverage and was not non-inferior to graft.
Randomized trial comparing xenogenic collagen matrix vs connective tissue graft for gingival recession over 36 months; collagen matrix provided less root coverage and was not non-inferior to graft.
Randomized trial comparing xenogenic collagen matrix vs connective tissue graft for gingival recession over 36 months; collagen matrix provided less root coverage and was not non-inferior to graft.
Immediate implants with buccal defects filled using DBBM + collagen membrane versus tuberosity bone showed similar ridge alterations, clinical parameters and patient-reported outcomes at 1 year.
Randomized clinical study of two graft materials with the same collagen barrier showed 100% implant survival and similar clinical and radiographic outcomes at 1-year post-loading.
Randomized trial of equine-derived collagenated xenogeneic bone block (CXBB) versus autogenous bone block (ABB) for lateral ridge augmentation; 1-year implant survival and clinical/aesthetic outcomes showed no statistically significant differences.
Immediate implants with buccal defects filled using DBBM + collagen membrane versus tuberosity bone showed similar ridge alterations, clinical parameters and patient-reported outcomes at 1 year.
Immediate implants with buccal defects filled using DBBM + collagen membrane versus tuberosity bone showed similar ridge alterations, clinical parameters and patient-reported outcomes at 1 year.
Randomized clinical trial measuring corneal biomechanics up to 1 year after corneal collagen cross-linking (CXL); no meaningful change in measured biomechanical indices at 1 year.
Patients receiving PTFE vascular grafts were randomized to collagen-containing TachoComb H patches or standard compression; time to haemostasis was shorter with the patch.
Randomized multicentre trial in vascular surgery showing collagen patch with fibrin components reduced time to haemostasis and local blood loss versus compresses.
Randomized multicentre trial in vascular surgery showing collagen patch with fibrin components reduced time to haemostasis and local blood loss versus compresses.
Randomized trial comparing woven vs collagen-impregnated knitted Dacron arterial grafts; knitted grafts had lower intraoperative blood loss but otherwise similar performance and patency at 1 year.
Using rhBMP-2 on an absorbable collagen sponge with interbody cages yielded higher fusion rates and less operative time and blood loss than autograft, avoiding donor-site morbidity.
Multicenter randomized trial showing a percutaneous collagen hemostasis device substantially reduced puncture-site hemostasis time and shortened time to ambulation versus manual compression, without increasing major complications.
Observer-masked RCT in adolescents showing corneal cross-linking (CXL) substantially slowed keratoconus progression and improved keratometry and visual acuity at 18 months versus standard care.
Observer-masked RCT in adolescents showing corneal cross-linking (CXL) substantially slowed keratoconus progression and improved keratometry and visual acuity at 18 months versus standard care.
Observer-masked RCT in adolescents showing corneal cross-linking (CXL) substantially slowed keratoconus progression and improved keratometry and visual acuity at 18 months versus standard care.
Small double-blind randomized trial in males: short-term collagen peptide supplementation modestly improved jump recovery and tended to reduce muscle soreness but did not affect inflammation or bone turnover markers.
Small double-blind randomized trial in males: short-term collagen peptide supplementation modestly improved jump recovery and tended to reduce muscle soreness but did not affect inflammation or bone turnover markers.
Two CXL methods in progressive keratoconus were compared over 24 months; both stabilized disease but standard (epi-off) CXL produced greater corneal flattening and deeper stromal effects.
Two CXL methods in progressive keratoconus were compared over 24 months; both stabilized disease but standard (epi-off) CXL produced greater corneal flattening and deeper stromal effects.
In pediatric keratoconus, both conventional and accelerated CXL improved vision and reduced corneal steepness with no progression over 3 years; differences were most evident at 1 year.
In pediatric keratoconus, both conventional and accelerated CXL improved vision and reduced corneal steepness with no progression over 3 years; differences were most evident at 1 year.
Adding a porcine-derived collagen scaffold (C-ACT) to microfracture led to better MRI repair (defect filling, integration) and improved pain/function outcomes versus microfracture alone through 24 months.
Adding a porcine-derived collagen scaffold (C-ACT) to microfracture led to better MRI repair (defect filling, integration) and improved pain/function outcomes versus microfracture alone through 24 months.
Adding a porcine-derived collagen scaffold (C-ACT) to microfracture led to better MRI repair (defect filling, integration) and improved pain/function outcomes versus microfracture alone through 24 months.
Both accelerated and conventional corneal collagen cross-linking increased corneal density at 6 months, especially in anterior and middle layers, with no major difference between methods.
Both accelerated and conventional corneal collagen cross-linking increased corneal density at 6 months, especially in anterior and middle layers, with no major difference between methods.
Both accelerated and conventional corneal collagen cross-linking increased corneal density at 6 months, especially in anterior and middle layers, with no major difference between methods.
Fifteen grams hydrolyzed collagen twice daily during 1 week of intense resistance training raised some plasma collagen-related amino acids but did not increase muscle myofibrillar or connective protein synthesis rates.
Fifteen grams hydrolyzed collagen twice daily during 1 week of intense resistance training raised some plasma collagen-related amino acids but did not increase muscle myofibrillar or connective protein synthesis rates.
At 12 months both transcrestal and lateral sinus floor elevation (latter with a resorbable collagen membrane) achieved near-complete radiographic implant embedding and minimal marginal bone loss.
At 12 months both transcrestal and lateral sinus floor elevation (latter with a resorbable collagen membrane) achieved near-complete radiographic implant embedding and minimal marginal bone loss.
Both bovine collagen injections and hylan B gel improved patients' voice and glottal closure at 12 months; collagen showed improvement but hylan B gel preserved vibration and increased phonation time more.
Both bovine collagen injections and hylan B gel improved patients' voice and glottal closure at 12 months; collagen showed improvement but hylan B gel preserved vibration and increased phonation time more.
Randomized trial comparing hylan B gel vs bovine cross-linked collagen injections for glottal insufficiency showed both improved voice and glottal closure; collagen showed more resorption/trend to more loss.
Both bovine collagen injections and hylan B gel improved patients' voice and glottal closure at 12 months; collagen showed improvement but hylan B gel preserved vibration and increased phonation time more.
The collagen-based CoStasis hemostat produced higher hemostatic success and much faster bleeding control than standard manual compression across multiple surgical specialties.
A sprayable collagen-thrombin-plasma composite stopped diffuse liver bleeding faster and more reliably than a collagen sponge applied with pressure.
The collagen-based CoStasis hemostat produced higher hemostatic success and much faster bleeding control than standard manual compression across multiple surgical specialties.
A sprayable collagen-thrombin-plasma composite stopped diffuse liver bleeding faster and more reliably than a collagen sponge applied with pressure.
In this randomized trial, PTFE patching had fewer ipsilateral strokes and less late recurrent stenosis than collagen-impregnated Dacron (Hemashield).
In this randomized trial, PTFE patching had fewer ipsilateral strokes and less late recurrent stenosis than collagen-impregnated Dacron (Hemashield).
In this randomized trial, PTFE patching had fewer ipsilateral strokes and less late recurrent stenosis than collagen-impregnated Dacron (Hemashield).
At 1 year, titanium meshes plus collagen membranes and reinforced PTFE membranes showed similar peri-implant bone loss and stable hard/soft tissues.
At 1 year, titanium meshes plus collagen membranes and reinforced PTFE membranes showed similar peri-implant bone loss and stable hard/soft tissues.
At 1 year, titanium meshes plus collagen membranes and reinforced PTFE membranes showed similar peri-implant bone loss and stable hard/soft tissues.
Topical collagen sealing after femoral artery access reduced compression time, shortened bedrest, and lowered bleeding rates versus pressure dressing.
Topical collagen sealing after femoral artery access reduced compression time, shortened bedrest, and lowered bleeding rates versus pressure dressing.
Topical collagen sealing after femoral artery access reduced compression time, shortened bedrest, and lowered bleeding rates versus pressure dressing.
One year after corneal collagen crosslinking, several corneal shape indices improved significantly, indicating improved corneal shape though visual acuity changes did not correlate.
One year after corneal collagen crosslinking, several corneal shape indices improved significantly, indicating improved corneal shape though visual acuity changes did not correlate.
One year after corneal collagen crosslinking, several corneal shape indices improved significantly, indicating improved corneal shape though visual acuity changes did not correlate.
Collagen membranes (native vs ribosome-crosslinked) gave similar clinical improvements in periodontal defect regeneration at 6 months.
Use of a dual anti-collagen membrane for guided tissue regeneration produced greater 1-year clinical attachment gains and bone density increases than an atelocollagen membrane; results were stable to 6 years.
Using a collagen membrane with bone graft produced similar tooth-supporting tissue gain as the alternative treatment over 12 months.
Collagen membranes (native vs ribosome-crosslinked) gave similar clinical improvements in periodontal defect regeneration at 6 months.
Topical collagen biomaterial (Collost) plus standard care produced greater wound area reduction and higher rates of epithelialization vs standard therapy over 4 weeks.
Topical collagen biomaterial (Collost) plus standard care produced greater wound area reduction and higher rates of epithelialization vs standard therapy over 4 weeks.
Topical collagen biomaterial (Collost) plus standard care produced greater wound area reduction and higher rates of epithelialization vs standard therapy over 4 weeks.
ARP using collagen-containing DBBM-C and collagen matrix did not change 1-year marginal bone loss compared with natural healing but had more early soft-tissue exposure.
ARP using collagen-containing DBBM-C and collagen matrix did not change 1-year marginal bone loss compared with natural healing but had more early soft-tissue exposure.
ARP using collagen-containing DBBM-C and collagen matrix did not change 1-year marginal bone loss compared with natural healing but had more early soft-tissue exposure.
Multicentre RCT comparing dPTFE vs collagen membrane for lateral bone augmentation at anterior maxilla; similar alveolar width outcomes but higher infection with dPTFE.
Multicentre RCT comparing dPTFE vs collagen membrane for lateral bone augmentation at anterior maxilla; similar alveolar width outcomes but higher infection with dPTFE.
In keratoconus patients, both conventional and accelerated corneal collagen cross-linking using methylcellulose-riboflavin improved visual acuity and maximum keratometry at 2 years with no difference between protocols.
Low-dose oral isotretinoin given thrice weekly for 3 months increased dermal collagen content and improved clinical signs of photoaging in women.
Low-dose oral isotretinoin given thrice weekly for 3 months increased dermal collagen content and improved clinical signs of photoaging in women.
Low-dose oral isotretinoin given thrice weekly for 3 months increased dermal collagen content and improved clinical signs of photoaging in women.
In patients needing large vertical maxillary augmentation, composite grafts containing rhBMP-2 on an acellular collagen sponge performed similarly to 100% autogenous grafts with slightly more viable new bone and less donor-site morbidity.
In patients needing large vertical maxillary augmentation, composite grafts containing rhBMP-2 on an acellular collagen sponge performed similarly to 100% autogenous grafts with slightly more viable new bone and less donor-site morbidity.
In patients needing large vertical maxillary augmentation, composite grafts containing rhBMP-2 on an acellular collagen sponge performed similarly to 100% autogenous grafts with slightly more viable new bone and less donor-site morbidity.
Using two types of xenogeneic collagen matrices with bone graft helped maintain soft tissues and limited ridge resorption after tooth extraction, with small increases in gingival thickness.
A xenogeneic collagen matrix worked as well as connective tissue graft to produce keratinized gum tissue and patients reported less pain and shorter surgery time.
Adding a xenogeneic collagen matrix to coronally advanced flap surgery increased keratinized tissue width and gingival thickness vs flap alone, while root coverage and patient satisfaction were similar at 12 months.
Adding i-PRF to autogenous demineralized dentin graft did not change alveolar ridge width loss but reduced patient-reported pain and better preserved keratinized tissue at 6 months.
A xenogeneic collagen matrix worked as well as connective tissue graft to produce keratinized gum tissue and patients reported less pain and shorter surgery time.
A xenogeneic collagen matrix worked as well as connective tissue graft to produce keratinized gum tissue and patients reported less pain and shorter surgery time.
Placing a gentamicin-containing collagen sponge into the wound after pilonidal sinus surgery sped healing and reduced infections and recurrences compared with oral antibiotics alone.
A matrix therapy agent (RGTA) after corneal collagen cross-linking sped corneal epithelial wound healing compared with hyaluronic acid drops.
A matrix therapy agent (RGTA) after corneal collagen cross-linking sped corneal epithelial wound healing compared with hyaluronic acid drops.
Adding cross-linked hyaluronic acid to connective tissue grafts did not change root coverage but increased elastic fibers and produced a modest (non-significant) increase in collagen density.
Adding cross-linked hyaluronic acid to connective tissue grafts did not change root coverage but increased elastic fibers and produced a modest (non-significant) increase in collagen density.
Randomized triple-blind trial: plasma (argon) cleaning of titanium abutments increased cell-covered area, altered collagen fiber density/orientation, and reduced contamination versus untreated abutments.
Alendronate prevented periprosthetic BMD loss around femoral implants and reduced serum N-terminal telopeptides of type-1 collagen; alfacalcidol preserved lumbar spine BMD but did not prevent periprosthetic loss.
Low-dose cyclical gallium nitrate reduced serum alkaline phosphatase and urinary markers of collagen turnover at higher doses in Paget's disease.
Losartan reduced myocardial collagen content and serum PIP compared with amlodipine, suggesting inhibition of collagen type I synthesis and regression of myocardial fibrosis.
Losartan reduced myocardial collagen content and serum PIP compared with amlodipine, suggesting inhibition of collagen type I synthesis and regression of myocardial fibrosis.
Losartan reduced myocardial collagen content and serum PIP compared with amlodipine, suggesting inhibition of collagen type I synthesis and regression of myocardial fibrosis.
In a randomized multicenter trial, adding an Ologen collagen matrix to Ahmed valve surgery did not improve IOP control, medication need, hypertensive phase incidence, or 1-year success compared with standard surgery.
In a randomized multicenter trial, adding an Ologen collagen matrix to Ahmed valve surgery did not improve IOP control, medication need, hypertensive phase incidence, or 1-year success compared with standard surgery.
Accelerated and standard corneal collagen crosslinking produced similar 6-month outcomes for keratoconus (visual acuity, refraction, topography); central corneal thickness was higher in the standard group.
Collagen cross-linking provided short-term symptomatic relief, reduced central corneal thickness and caused anterior stromal compaction in PBK patients.
Randomized study of nonpenetrating deep sclerectomy with a collagen implant, comparing adjunctive mitomycin C versus no MMC in glaucoma patients.
Accelerated and standard corneal collagen crosslinking produced similar 6-month outcomes for keratoconus (visual acuity, refraction, topography); central corneal thickness was higher in the standard group.
Randomized study comparing porcine collagen graft (Pelvicol) vs conventional repair showed no improvement in POP-Q stage at 12 months despite slightly better Ba point improvement with graft.
Randomized study comparing porcine collagen graft (Pelvicol) vs conventional repair showed no improvement in POP-Q stage at 12 months despite slightly better Ba point improvement with graft.
Randomized study comparing porcine collagen graft (Pelvicol) vs conventional repair showed no improvement in POP-Q stage at 12 months despite slightly better Ba point improvement with graft.
Adding a collagen-enriched bovine-derived xenograft to M-MIST improved probing depth reduction, clinical attachment gain and radiographic bone volume at 2 years versus M-MIST alone.
Adding a collagen-enriched bovine-derived xenograft to M-MIST improved probing depth reduction, clinical attachment gain and radiographic bone volume at 2 years versus M-MIST alone.
Adding a collagen-enriched bovine-derived xenograft to M-MIST improved probing depth reduction, clinical attachment gain and radiographic bone volume at 2 years versus M-MIST alone.
In 40 patients undergoing sinus augmentation, covering the lateral window with a collagen membrane produced comparable bone formation, surgical outcomes, and patient discomfort to bony wall repositioning.
No statistically significant differences were found between Alloderm-RTU and DermACELL in drain duration or rates of minor/major complications in immediate subpectoral implant-based breast reconstruction.
No statistically significant differences were found between Alloderm-RTU and DermACELL in drain duration or rates of minor/major complications in immediate subpectoral implant-based breast reconstruction.
No statistically significant differences were found between Alloderm-RTU and DermACELL in drain duration or rates of minor/major complications in immediate subpectoral implant-based breast reconstruction.
Higher peripheral collagen turnover markers were associated with increased composite death/hospitalization in univariable analyses but were not independent predictors in multivariable models.
Higher peripheral collagen turnover markers were associated with increased composite death/hospitalization in univariable analyses but were not independent predictors in multivariable models.
Higher peripheral collagen turnover markers were associated with increased composite death/hospitalization in univariable analyses but were not independent predictors in multivariable models.
Trabeculectomy with porcine Ologen collagen implant produced similar overall success rates to MMC-augmented trabeculectomy, with comparable IOP control but more transient hyphema in the Ologen group.
Trabeculectomy with porcine Ologen collagen implant produced similar overall success rates to MMC-augmented trabeculectomy, with comparable IOP control but more transient hyphema in the Ologen group.
Trabeculectomy with porcine Ologen collagen implant produced similar overall success rates to MMC-augmented trabeculectomy, with comparable IOP control but more transient hyphema in the Ologen group.
Collagen gel injections reduced urinary leakage and incontinence in women with stress urinary incontinence with similar efficacy to a hydrogel at 12 months.
Collagen gel injections reduced urinary leakage and incontinence in women with stress urinary incontinence with similar efficacy to a hydrogel at 12 months.
Collagen gel injections reduced urinary leakage and incontinence in women with stress urinary incontinence with similar efficacy to a hydrogel at 12 months.
Adding 10% collagen to deproteinized bovine bone mineral produced similar dimensional and histological outcomes to the material without collagen after 5 months.
Adding 10% collagen to deproteinized bovine bone mineral produced similar dimensional and histological outcomes to the material without collagen after 5 months.
An anchor-collagen based closure device (Angio-Seal) had high deployment success, low vascular complications, and reduced nursing time compared with manual compression.
An anchor-collagen based closure device (Angio-Seal) had high deployment success, low vascular complications, and reduced nursing time compared with manual compression.
An anchor-collagen based closure device (Angio-Seal) had high deployment success, low vascular complications, and reduced nursing time compared with manual compression.
Corneal collagen cross-linking slowed or halted keratoconus progression in treated eyes versus the untreated contralateral eyes at 1 year.
Corneal collagen cross-linking slowed or halted keratoconus progression in treated eyes versus the untreated contralateral eyes at 1 year.
Corneal collagen cross-linking slowed or halted keratoconus progression in treated eyes versus the untreated contralateral eyes at 1 year.
Socket sealing with collagen matrix or membrane produced similar dimensional and histologic outcomes to other sealing approaches over 4–6 months.
Socket sealing with collagen matrix or membrane produced similar dimensional and histologic outcomes to other sealing approaches over 4–6 months.
Long-term follow-up in patients comparing collagen matrix to traditional graft; collagen matrix performed similarly for preventing recession and had better tissue match and patient preference.
Long-term follow-up in patients comparing collagen matrix to traditional graft; collagen matrix performed similarly for preventing recession and had better tissue match and patient preference.
Long-term follow-up in patients comparing collagen matrix to traditional graft; collagen matrix performed similarly for preventing recession and had better tissue match and patient preference.
Clinical trial of corneal collagen cross-linking showing greater corneal flattening and vision improvement when the ectatic cone was centrally located.
In patients with keratoconus, intracorneal ring segments plus corneal collagen crosslinking improved corneal topography and vision substantially; concurrent versus sequential timing showed equivalent outcomes.
In 179 subjects with post-refractive corneal ectasia, corneal collagen crosslinking (CXL) reduced progression and improved vision at 1 year versus sham.
Replacing methotrexate with daily oral collagen type II (0.5 mg) worsened disease activity in patients with long-standing rheumatoid arthritis.
Specific collagen peptide supplementation (5 g/day) combined with resistance training increased Achilles tendon size and muscle thickness more than placebo in young men.
Specific collagen peptide supplementation (5 g/day) combined with resistance training increased Achilles tendon size and muscle thickness more than placebo in young men.
Specific collagen peptide supplementation (5 g/day) combined with resistance training increased Achilles tendon size and muscle thickness more than placebo in young men.
Traditional corneal cross-linking produced greater corneal structural changes (decreased keratocyte density, more edema/activation, deeper persistent stromal line) than transepithelial CXL.
Traditional corneal cross-linking produced greater corneal structural changes (decreased keratocyte density, more edema/activation, deeper persistent stromal line) than transepithelial CXL.
Traditional corneal cross-linking produced greater corneal structural changes (decreased keratocyte density, more edema/activation, deeper persistent stromal line) than transepithelial CXL.
Eight weeks of daily Shilajit (500 or 1000 mg) increased serum pro-c1α1, a marker of type I collagen synthesis, compared with placebo.
Eight weeks of daily Shilajit (500 or 1000 mg) increased serum pro-c1α1, a marker of type I collagen synthesis, compared with placebo.
Compared conventional (Dresden) vs accelerated corneal collagen cross-linking in progressive keratoconus; conventional protocol produced greater topographic flattening and some visual improvement at 6 months.
Compared conventional (Dresden) vs accelerated corneal collagen cross-linking in progressive keratoconus; conventional protocol produced greater topographic flattening and some visual improvement at 6 months.
Compared conventional (Dresden) vs accelerated corneal collagen cross-linking in progressive keratoconus; conventional protocol produced greater topographic flattening and some visual improvement at 6 months.
In keratoconus patients, corneal collagen cross-linking combined with intrastromal ring segments produced additional refractive and uncorrected visual acuity benefits at 1 year compared with cross-linking alone.
In keratoconus patients, corneal collagen cross-linking combined with intrastromal ring segments produced additional refractive and uncorrected visual acuity benefits at 1 year compared with cross-linking alone.
In keratoconus patients, corneal collagen cross-linking combined with intrastromal ring segments produced additional refractive and uncorrected visual acuity benefits at 1 year compared with cross-linking alone.
Randomized study of extraction socket treatments found that collagen plug alone (control) had more new bone and organic matrix at 8 weeks than grafted sites; adding growth factors led to faster graft particle turnover.
Randomized clinical trial comparing flapped vs flapless socket grafting with porcine bone and collagen membrane found similar histological outcomes after 3 months.
Randomized study of extraction socket treatments found that collagen plug alone (control) had more new bone and organic matrix at 8 weeks than grafted sites; adding growth factors led to faster graft particle turnover.
Randomized study of extraction socket treatments found that collagen plug alone (control) had more new bone and organic matrix at 8 weeks than grafted sites; adding growth factors led to faster graft particle turnover.
Using a collagen membrane to cover sinus grafts improved implant survival, particularly for implants loaded at 6–9 months.
Porcine collagen membrane performed as well as a PEG membrane for guided bone regeneration around single-tooth implants at 5 years.
Porcine collagen membrane performed as well as a PEG membrane for guided bone regeneration around single-tooth implants at 5 years.
Porcine collagen membrane performed as well as a PEG membrane for guided bone regeneration around single-tooth implants at 5 years.
Corneal collagen cross-linking led to significant epithelial thinning and a more regular epithelial thickness profile, with no consistent stromal changes at 1–3 months.
Corneal collagen cross-linking led to significant epithelial thinning and a more regular epithelial thickness profile, with no consistent stromal changes at 1–3 months.
Corneal collagen cross-linking led to significant epithelial thinning and a more regular epithelial thickness profile, with no consistent stromal changes at 1–3 months.
Daily 15 g specific collagen peptides plus 12-week resistance training increased fat-free mass and reduced fat mass more than placebo in overweight middle-aged men.
Daily 15 g specific collagen peptides plus 12-week resistance training increased fat-free mass and reduced fat mass more than placebo in overweight middle-aged men.
A post-exercise beverage containing 25 g whey plus 5 g collagen increased plasma amino acids and raised myofibrillar and muscle connective protein synthesis at rest; after exercise it increased myofibrillar but not connective synthesis.
A post-exercise beverage containing 25 g whey plus 5 g collagen increased plasma amino acids and raised myofibrillar and muscle connective protein synthesis at rest; after exercise it increased myofibrillar but not connective synthesis.
A post-exercise beverage containing 25 g whey plus 5 g collagen increased plasma amino acids and raised myofibrillar and muscle connective protein synthesis at rest; after exercise it increased myofibrillar but not connective synthesis.
Rehab plus oral collagen-containing supplement produced greater and more sustained improvements in pain, disability, and physical QoL than rehab alone.
Rehab plus oral collagen-containing supplement produced greater and more sustained improvements in pain, disability, and physical QoL than rehab alone.
Rehab plus oral collagen-containing supplement produced greater and more sustained improvements in pain, disability, and physical QoL than rehab alone.
Collagen cross-linking reduced corneal thickness short-term but provided no sustained improvement in pain, clarity, or vision and had higher rates of recurrent epithelial defects.
Collagen cross-linking reduced corneal thickness short-term but provided no sustained improvement in pain, clarity, or vision and had higher rates of recurrent epithelial defects.
Adding intrastromal collagen cross-linking to hyperopic LASIK reduced long-term regression and gave better uncorrected vision than LASIK alone at 2 years.
Adding intrastromal collagen cross-linking to hyperopic LASIK reduced long-term regression and gave better uncorrected vision than LASIK alone at 2 years.
Adding gentamicin-collagen sponges did not reduce surgical site infections after hemiarthroplasty in elderly patients.
Adding gentamicin-collagen sponges did not reduce surgical site infections after hemiarthroplasty in elderly patients.
Adding gentamicin-collagen sponges did not reduce surgical site infections after hemiarthroplasty in elderly patients.
Porcine-derived collagen matrix (PDCM) produced better root coverage and less pain/time than connective tissue grafts in smokers.
Collagen cross-linking provided short-term symptomatic relief, reduced central corneal thickness and caused anterior stromal compaction in PBK patients.
A collagen-based composite (CoStasis) achieved faster and more complete hemostasis than manual compression with a collagen sponge.
A collagen-based composite (CoStasis) achieved faster and more complete hemostasis than manual compression with a collagen sponge.
A collagen-based composite (CoStasis) achieved faster and more complete hemostasis than manual compression with a collagen sponge.
Adding UV-A/riboflavin corneal collagen cross-linking sped healing and shortened treatment time for moderate bacterial corneal ulcers.
Adding UV-A/riboflavin corneal collagen cross-linking sped healing and shortened treatment time for moderate bacterial corneal ulcers.
Adding UV-A/riboflavin corneal collagen cross-linking sped healing and shortened treatment time for moderate bacterial corneal ulcers.
Corneal collagen crosslinking and riboflavin application altered corneal surface temperature; pre-heated oxygen raised temperature more markedly.
Corneal collagen crosslinking and riboflavin application altered corneal surface temperature; pre-heated oxygen raised temperature more markedly.
Corneal collagen crosslinking and riboflavin application altered corneal surface temperature; pre-heated oxygen raised temperature more markedly.
In elderly osteoporotic women, alendronate increased lumbar BMD and reduced bone resorption more than etidronate; both treatments reduced back pain.
Randomized trial comparing phenol deep peel vs percutaneous collagen induction + TCA for atrophic post-acne scars; both treatments produced large scar improvements.
Randomized trial comparing a collagen-based vascular hemostasis device (VasoSeal) to manual compression after PTCA; VasoSeal reduced hemostasis time, ambulation time, and hospital/nursing resource use.
Randomized trial comparing a collagen-based vascular hemostasis device (VasoSeal) to manual compression after PTCA; VasoSeal reduced hemostasis time, ambulation time, and hospital/nursing resource use.
Randomized trial comparing a collagen-based vascular hemostasis device (VasoSeal) to manual compression after PTCA; VasoSeal reduced hemostasis time, ambulation time, and hospital/nursing resource use.
Genetic association studies showing COL3A1 polymorphisms influence coronary disease risk; certain alleles were protective while others modified treatment response.
Genetic association studies showing COL3A1 polymorphisms influence coronary disease risk; certain alleles were protective while others modified treatment response.
Genetic association studies showing COL3A1 polymorphisms influence coronary disease risk; certain alleles were protective while others modified treatment response.
In older men, twice-daily whey or pea protein (2×25 g) increased integrated muscle protein synthesis by ~9%, whereas twice-daily collagen (2×25 g) did not change integrated MPS.
In older men, twice-daily whey or pea protein (2×25 g) increased integrated muscle protein synthesis by ~9%, whereas twice-daily collagen (2×25 g) did not change integrated MPS.
In older men, twice-daily whey or pea protein (2×25 g) increased integrated muscle protein synthesis by ~9%, whereas twice-daily collagen (2×25 g) did not change integrated MPS.
Use of a hyaluronic acid spray containing amino acids that are collagen precursors (Mucosamin®), especially with professional oral hygiene, reduced severity and duration of oral mucositis after stem cell transplant.
Use of a hyaluronic acid spray containing amino acids that are collagen precursors (Mucosamin®), especially with professional oral hygiene, reduced severity and duration of oral mucositis after stem cell transplant.
Use of a hyaluronic acid spray containing amino acids that are collagen precursors (Mucosamin®), especially with professional oral hygiene, reduced severity and duration of oral mucositis after stem cell transplant.
In elective colorectal surgery, adding a gentamicin-collagen sponge to systemic antibiotics lowered postoperative wound infection rates compared with systemic antibiotics alone.
Large randomized trial showing gentamicin-laced collagen tampons placed over prosthetic mesh reduced postoperative wound infections after groin hernia repair.
In elective colorectal surgery, adding a gentamicin-collagen sponge to systemic antibiotics lowered postoperative wound infection rates compared with systemic antibiotics alone.
Using an absorbable gentamicin‑impregnated collagen matrix to seal extraction sockets produced very small bone width loss and more blood vessel ingrowth but no statistically significant reduction in resorption overall.
Using an absorbable gentamicin‑impregnated collagen matrix to seal extraction sockets produced very small bone width loss and more blood vessel ingrowth but no statistically significant reduction in resorption overall.
Epithelium‑off corneal collagen cross‑linking halted keratoconus progression and reduced maximum K, while transepithelial treatment was less effective and many patients progressed.
Longer left atrial epicardial conduction time (LAECT) was associated with more AF recurrences; higher interstitial collagen fibre density correlated with shorter LAECT.
Longer left atrial epicardial conduction time (LAECT) was associated with more AF recurrences; higher interstitial collagen fibre density correlated with shorter LAECT.
Longer left atrial epicardial conduction time (LAECT) was associated with more AF recurrences; higher interstitial collagen fibre density correlated with shorter LAECT.
Teriparatide treatment produced bone with lower matrix mineralization, lower mineral crystallinity and reduced collagen cross‑link ratio compared with placebo, resembling younger bone matrix characteristics.
Teriparatide treatment produced bone with lower matrix mineralization, lower mineral crystallinity and reduced collagen cross‑link ratio compared with placebo, resembling younger bone matrix characteristics.
Teriparatide treatment produced bone with lower matrix mineralization, lower mineral crystallinity and reduced collagen cross‑link ratio compared with placebo, resembling younger bone matrix characteristics.
Adding anorganic bovine bone to a collagen membrane (CPRT) produced greater attachment gains and more vertical bone gain than collagen membrane alone after 1 year.
Randomized clinical trial in 40 patients comparing d-PTFE (non-resorbable) membranes versus Ti-mesh covered with cross-linked collagen membrane for guided bone regeneration; both achieved similar vertical bone gain and comparable healing complication rates.
In this randomized trial, covering customized titanium mesh with a resorbable (cross-linked collagen) membrane tended to reduce healing complications and improve regenerated bone volume compared with mesh alone, though differences were not statistically significant.
Randomized clinical trial in 40 patients comparing d-PTFE (non-resorbable) membranes versus Ti-mesh covered with cross-linked collagen membrane for guided bone regeneration; both achieved similar vertical bone gain and comparable healing complication rates.
Randomized clinical trial in 40 patients comparing d-PTFE (non-resorbable) membranes versus Ti-mesh covered with cross-linked collagen membrane for guided bone regeneration; both achieved similar vertical bone gain and comparable healing complication rates.
Pilot RCT (27 patients) comparing PRF membranes versus standard DBBM plus resorbable collagen membrane for augmented sites; implant survival similar and PRF group had a slightly better peri-implant marginal bone level at 2-year follow-up.
Split-mouth RCT (30 patients enrolled; 24 completed at 5 years) comparing conventional total-etch adhesive versus dentine deproteinization with 10% NaOCl (collagen removal); no difference in clinical performance after 5 years.
A sprayable collagen-thrombin-plasma composite stopped diffuse liver bleeding faster and more reliably than a collagen sponge applied with pressure.
In vivo dermatological evaluation of topical formulations containing lyophilized hydrolyzed blue shark cartilage (collagen) applied to inner wrists of volunteers with skin measurements at baseline, 10 min and 20 min.
In vivo dermatological evaluation of topical formulations containing lyophilized hydrolyzed blue shark cartilage (collagen) applied to inner wrists of volunteers with skin measurements at baseline, 10 min and 20 min.
Double-blind placebo-controlled randomized trial in recreationally active young men testing 15 g/day collagen peptides vs placebo during 15 weeks of lower-body resistance training; measured tendon size and mechanical properties.
Double-blind placebo-controlled randomized trial in recreationally active young men testing 15 g/day collagen peptides vs placebo during 15 weeks of lower-body resistance training; measured tendon size and mechanical properties.
Double-blind placebo-controlled randomized trial in recreationally active young men testing 15 g/day collagen peptides vs placebo during 15 weeks of lower-body resistance training; measured tendon size and mechanical properties.
Randomized trial comparing ridge preservation techniques including demineralized bovine bone mineral with 10% collagen plus collagen matrix or soft-tissue graft versus controls; CBCT assessed ridge changes after 6 months.
Randomized trial comparing ridge preservation techniques including demineralized bovine bone mineral with 10% collagen plus collagen matrix or soft-tissue graft versus controls; CBCT assessed ridge changes after 6 months.
Randomized trial comparing atelocollagen implant vs mitomycin C during trabeculectomy; the collagen implant group had less pressure reduction and lower surgical success than MMC.
In phacotrabeculectomy, the collagen matrix implant and mitomycin C produced similar intraocular pressure lowering and success rates at 12 months.
Postoperative oral prednisolone lowered serum markers of collagen synthesis systemically but did not improve surgical success of Molteno implantation over 6 months.
A multicentre randomized trial found collagen meniscus implants supported new meniscus-like tissue growth and improved activity and reoperation rates in patients with chronic meniscal injury.
A multicentre randomized trial found collagen meniscus implants supported new meniscus-like tissue growth and improved activity and reoperation rates in patients with chronic meniscal injury.
A multicentre randomized trial found collagen meniscus implants supported new meniscus-like tissue growth and improved activity and reoperation rates in patients with chronic meniscal injury.
In patients with keratoconus, intracorneal ring segments plus corneal collagen crosslinking improved corneal topography and vision substantially; concurrent versus sequential timing showed equivalent outcomes.
Alendronate increased bone mineral density over 2.5 years; all subjects received calcium and vitamin D but the study did not test vitamin D effects.
Alendronate increased bone mineral density over 2.5 years; all subjects received calcium and vitamin D but the study did not test vitamin D effects.
A 90-day randomized trial found that ortho-silicic acid stabilized by hydrolyzed marine collagen improved skin firmness, hydration, and texture by clinical assessment.
Randomized double-blind vehicle-controlled 12-week trial of a topical firming/toning lotion (FTB) in 54 women showed significant improvements in skin firmness, texture, and cellulite and preclinical evidence of increased collagen and elastic fiber formation.
Using Alloderm (acellular dermal matrix) in hypospadias repair reduced postoperative fistula rates compared with standard repair.
Using Alloderm (acellular dermal matrix) in hypospadias repair reduced postoperative fistula rates compared with standard repair.
Using Alloderm (acellular dermal matrix) in hypospadias repair reduced postoperative fistula rates compared with standard repair.
Volume-stable collagen matrix was as effective as connective tissue graft for papilla reconstruction and caused less post-operative pain.
Volume-stable collagen matrix was as effective as connective tissue graft for papilla reconstruction and caused less post-operative pain.
Volume-stable collagen matrix was as effective as connective tissue graft for papilla reconstruction and caused less post-operative pain.
Randomized comparison of femoral closure devices including AngioSeal (anchor + collagen sponge) showed no device-related differences in systemic inflammatory markers; IL-6 rose at 6 hours in all groups.
A skin graft product containing a collagen matrix helped long-standing venous leg ulcers heal faster and in more people than standard compression alone.
A skin graft product containing a collagen matrix helped long-standing venous leg ulcers heal faster and in more people than standard compression alone.
At 6 years, using a resorbable collagen barrier gave similar bone levels and no more complications than a nonresorbable titanium-reinforced barrier.
At 6 years, using a resorbable collagen barrier gave similar bone levels and no more complications than a nonresorbable titanium-reinforced barrier.
Randomized, double-blind 24-week pilot trial in knee OA patients comparing HC-II (type II collagen hydrolysate), EC-HC-II (chicken essence + HC-II), glucosamine, and placebo; HC-II reduced early pain and EC-HC-II increased fat-free mass and grip strength versus some comparators.
Topical type I collagen powder showed a non-significant trend to less overall drainage; in patients with >10 nodes removed it significantly reduced lymphorrhea volume and duration.
Randomized prospective single-center study testing a collagen-based sealant patch (TachoSil) versus standard care in RLND for melanoma; patch reduced drainage duration and increased % drainage-free at day 21.
Randomized prospective single-center study testing a collagen-based sealant patch (TachoSil) versus standard care in RLND for melanoma; patch reduced drainage duration and increased % drainage-free at day 21.
Randomized prospective single-center study testing a collagen-based sealant patch (TachoSil) versus standard care in RLND for melanoma; patch reduced drainage duration and increased % drainage-free at day 21.
Randomized pilot study in endometrial cancer patients undergoing pelvic lymphadenectomy: application of a collagen patch (TachoSil) reduced lymphocele formation and symptomatic cases.
Use of a fibrinogen/coagulation-factor coated collagen patch (TachoSil) at lymphadenectomy sites was associated with lower drainage volume and fewer lymphoceles compared with historical controls.
Randomized pilot study in endometrial cancer patients undergoing pelvic lymphadenectomy: application of a collagen patch (TachoSil) reduced lymphocele formation and symptomatic cases.
Use of a fibrinogen/coagulation-factor coated collagen patch (TachoSil) at lymphadenectomy sites was associated with lower drainage volume and fewer lymphoceles compared with historical controls.
Randomized pilot study in endometrial cancer patients undergoing pelvic lymphadenectomy: application of a collagen patch (TachoSil) reduced lymphocele formation and symptomatic cases.
Porcine collagen matrix used with a tunnel technique reduced surgery time and morbidity but provided less complete root coverage than palatal connective tissue grafts; both improved gingival measures at 12 months.
In PAOO patients, collagen barrier membrane (control) increased gingival thickness modestly at 6 months, but CGF membrane produced a larger increase; both groups showed bone parameter changes.
Porcine collagen matrix used with a tunnel technique reduced surgery time and morbidity but provided less complete root coverage than palatal connective tissue grafts; both improved gingival measures at 12 months.
A collagen-laminin dermal matrix (Dermalix) accelerated wound closure and reduced oxidative stress markers versus standard wound care in Wagner 1–2 diabetic foot ulcers over 4 weeks.
A collagen-laminin dermal matrix (Dermalix) accelerated wound closure and reduced oxidative stress markers versus standard wound care in Wagner 1–2 diabetic foot ulcers over 4 weeks.
A collagen-laminin dermal matrix (Dermalix) accelerated wound closure and reduced oxidative stress markers versus standard wound care in Wagner 1–2 diabetic foot ulcers over 4 weeks.
In bullous pemphigoid patients, higher IgG autoantibodies against BP180 (a noncollagenous domain of type XVII collagen) were associated with lower functional status and higher 1-year mortality.
In bullous pemphigoid patients, higher IgG autoantibodies against BP180 (a noncollagenous domain of type XVII collagen) were associated with lower functional status and higher 1-year mortality.
In bullous pemphigoid patients, higher IgG autoantibodies against BP180 (a noncollagenous domain of type XVII collagen) were associated with lower functional status and higher 1-year mortality.
In patients with keratoconus, intracorneal ring segments plus corneal collagen crosslinking improved corneal topography and vision substantially; concurrent versus sequential timing showed equivalent outcomes.
In chronic hepatitis C patients, drinking 4 cups of coffee/day reduced markers of oxidative damage and serum collagen levels, and increased telomere length versus abstinence over 30 days.
In chronic hepatitis C patients, drinking 4 cups of coffee/day reduced markers of oxidative damage and serum collagen levels, and increased telomere length versus abstinence over 30 days.
In chronic hepatitis C patients, drinking 4 cups of coffee/day reduced markers of oxidative damage and serum collagen levels, and increased telomere length versus abstinence over 30 days.
Corneal cross-linking reduced goblet cell density on the superior conjunctiva; topical riboflavin improved epithelial cell morphology in another group, with no difference in total scores between groups.
Corneal cross-linking reduced goblet cell density on the superior conjunctiva; topical riboflavin improved epithelial cell morphology in another group, with no difference in total scores between groups.
Corneal cross-linking reduced goblet cell density on the superior conjunctiva; topical riboflavin improved epithelial cell morphology in another group, with no difference in total scores between groups.
Six months of oestradiol in postmenopausal women decreased total vaginal collagen and markers of aged collagen while increasing immature cross-links and MMP-2 expression, indicating stimulated collagen turnover.
Six months of oestradiol in postmenopausal women decreased total vaginal collagen and markers of aged collagen while increasing immature cross-links and MMP-2 expression, indicating stimulated collagen turnover.
Two collagen-based topical hemostatic sponges achieved similar rates of hemostasis during cardiothoracic surgery; one had better handling characteristics.
Two collagen-based topical hemostatic sponges achieved similar rates of hemostasis during cardiothoracic surgery; one had better handling characteristics.
Corneal collagen crosslinking improved vision and corneal curvature over one year versus sham (riboflavin alone), with many patients gaining lines of vision and mean K values decreasing.
Local gentamicin–collagen applied during abdominoperineal resection did not reduce perineal wound complications nor change cancer recurrence rates.
Local gentamicin–collagen applied during abdominoperineal resection did not reduce perineal wound complications nor change cancer recurrence rates.
31 renal-allograft recipients randomized to cyclosporine reduction with or without rapamycin; rapamycin group had a fall in GFR and increases in collagen III expression and TIMP-2 without histological improvement in interstitial fibrosis.
Mechanical skin stimulation produced clinically improved radiance/relief and increased fibroblast migration and MMP-9 synthesis, with a trend toward improved sagging.
Mechanical skin stimulation produced clinically improved radiance/relief and increased fibroblast migration and MMP-9 synthesis, with a trend toward improved sagging.
Mechanical skin stimulation produced clinically improved radiance/relief and increased fibroblast migration and MMP-9 synthesis, with a trend toward improved sagging.
At 4 years, standard corneal cross-linking produced greater anterior corneal flattening than accelerated CXL (especially for peripheral cones); differences in visual acuity were not statistically significant.
Adding transepithelial corneal collagen cross-linking to intracorneal ring surgery improved vision and reduced spherical refractive error more than ring surgery alone.
At 4 years, standard corneal cross-linking produced greater anterior corneal flattening than accelerated CXL (especially for peripheral cones); differences in visual acuity were not statistically significant.
At 4 years, standard corneal cross-linking produced greater anterior corneal flattening than accelerated CXL (especially for peripheral cones); differences in visual acuity were not statistically significant.
Permacol (porcine dermal collagen) injections improved urinary stress incontinence measures more than Macroplastique, with effects sustained to 6 months.
Permacol (porcine dermal collagen) injections improved urinary stress incontinence measures more than Macroplastique, with effects sustained to 6 months.
Permacol (porcine dermal collagen) injections improved urinary stress incontinence measures more than Macroplastique, with effects sustained to 6 months.
Using two types of xenogeneic collagen matrices with bone graft helped maintain soft tissues and limited ridge resorption after tooth extraction, with small increases in gingival thickness.
A 12-week oral chicken sternal cartilage (BioCell Collagen) supplement increased skin collagen and elasticity and reduced wrinkle severity versus placebo.
A 12-week oral chicken sternal cartilage (BioCell Collagen) supplement increased skin collagen and elasticity and reduced wrinkle severity versus placebo.
Randomized trial comparing hylan B gel vs bovine cross-linked collagen injections for glottal insufficiency showed both improved voice and glottal closure; collagen showed more resorption/trend to more loss.
Randomized trial comparing hylan B gel vs bovine cross-linked collagen injections for glottal insufficiency showed both improved voice and glottal closure; collagen showed more resorption/trend to more loss.
Two weeks of calf intermittent pneumatic compression (IPC) during immobilization markedly increased markers of collagen type I production in healing Achilles tendons but did not change clinical outcomes at 3 or 12 months.
Two weeks of calf intermittent pneumatic compression (IPC) during immobilization markedly increased markers of collagen type I production in healing Achilles tendons but did not change clinical outcomes at 3 or 12 months.
Two weeks of calf intermittent pneumatic compression (IPC) during immobilization markedly increased markers of collagen type I production in healing Achilles tendons but did not change clinical outcomes at 3 or 12 months.
Small randomized study in postmenopausal osteopenic women: adding bioactive collagen peptides to calcium+vitamin D lowered bone turnover markers over 3 months compared with calcium+vitamin D alone.
In 45 postmenopausal osteopenic women, a 12-week supervised walking program improved function and increased bone turnover markers (P1NP, CTX) with osteocalcin rising in the exercise group; both groups received vitamin D and calcium.
Small randomized study in postmenopausal osteopenic women: adding bioactive collagen peptides to calcium+vitamin D lowered bone turnover markers over 3 months compared with calcium+vitamin D alone.
A designed tetrapeptide (GEKG) increased collagen production in vitro and showed significant reduction in skin roughness (wrinkles) in a 30-participant clinical evaluation.
A designed tetrapeptide (GEKG) increased collagen production in vitro and showed significant reduction in skin roughness (wrinkles) in a 30-participant clinical evaluation.
4-year randomized trial (SONIA 2) in alkaptonuria patients showing nitisinone alters trajectories of type I (bone) and type II (cartilage) collagen turnover biomarkers.
In postmenopausal volunteers with low vitamin D, oral calcium produced marked suppression of bone resorption marker CTX (greater than vitamin D alone); vitamin D alone raised serum 25OHD but had smaller CTX effects.
Compared salivary CTXI and implant stability (Periotest) in 40 patients randomized to early vs delayed implant loading; CTXI was essentially undetectable while early loading showed improved mechanical stability at 1 month.
Compared salivary CTXI and implant stability (Periotest) in 40 patients randomized to early vs delayed implant loading; CTXI was essentially undetectable while early loading showed improved mechanical stability at 1 month.
Randomized double-blind placebo-controlled trial (72 women) of daily 5 g tuna collagen peptides for 8 weeks: improved skin hydration, reduced TEWL, increased elasticity and skin density versus placebo; effects partly sustained 2 weeks after stopping.
Randomized double-blind placebo-controlled trial (72 women) of daily 5 g tuna collagen peptides for 8 weeks: improved skin hydration, reduced TEWL, increased elasticity and skin density versus placebo; effects partly sustained 2 weeks after stopping.
Randomized double-blind placebo-controlled trial (72 women) of daily 5 g tuna collagen peptides for 8 weeks: improved skin hydration, reduced TEWL, increased elasticity and skin density versus placebo; effects partly sustained 2 weeks after stopping.
Cohort study of corneal collagen crosslinking (CXL) finding that worse preoperative vision and higher maximum K predict greater improvement after CXL.
Cohort study of corneal collagen crosslinking (CXL) finding that worse preoperative vision and higher maximum K predict greater improvement after CXL.
Cohort study of corneal collagen crosslinking (CXL) finding that worse preoperative vision and higher maximum K predict greater improvement after CXL.
Randomized feeding study: the DASH diet lowered bone turnover markers and sodium reduction decreased calcium excretion and some bone markers; vitamin D was discussed but not tested.
4-year randomized trial (SONIA 2) in alkaptonuria patients showing nitisinone alters trajectories of type I (bone) and type II (cartilage) collagen turnover biomarkers.
4-year randomized trial (SONIA 2) in alkaptonuria patients showing nitisinone alters trajectories of type I (bone) and type II (cartilage) collagen turnover biomarkers.
PACK-CXL added to antimicrobials did not shorten healing time but had fewer serious complications (no perforations or recurrences) than antimicrobials alone.
PACK-CXL added to antimicrobials did not shorten healing time but had fewer serious complications (no perforations or recurrences) than antimicrobials alone.
L-PRF+IBB was non-inferior to collagen membrane+IBB for clinical attachment gain and produced less gingival recession, though it had slightly less probing-depth reduction.
Eplerenone did not improve exercise capacity but significantly reduced serum markers of collagen turnover and improved diastolic function.
Eplerenone did not improve exercise capacity but significantly reduced serum markers of collagen turnover and improved diastolic function.
Eplerenone did not improve exercise capacity but significantly reduced serum markers of collagen turnover and improved diastolic function.
Eplerenone did not improve exercise capacity but significantly reduced serum markers of collagen turnover and improved diastolic function.
MK-677 raised IGF-I and bone-turnover markers and, when combined with alendronate, lessened alendronate's suppression of bone formation and increased femoral neck BMD more than alendronate alone.
MK-677 raised IGF-I and bone-turnover markers and, when combined with alendronate, lessened alendronate's suppression of bone formation and increased femoral neck BMD more than alendronate alone.
In renal transplant recipients, adding alendronate to calcium and calcitriol increased femoral neck BMD and decreased bone resorption marker NTx versus calcium+calcitriol alone in the short term.
Pyridoxamine tended to raise a bone formation marker, increased femoral neck BMD, and slightly lowered HbA1c in older women with T2D.
MK-677 raised IGF-I and bone-turnover markers and, when combined with alendronate, lessened alendronate's suppression of bone formation and increased femoral neck BMD more than alendronate alone.
Transdermal estradiol+levonorgestrel increased BMD (lumbar spine, hip, total body) and reduced bone turnover markers over 2 years.
Transdermal estradiol+levonorgestrel increased BMD (lumbar spine, hip, total body) and reduced bone turnover markers over 2 years.
Corneal collagen crosslinking significantly reduced corneal and ocular higher-order aberrations at 1 year, suggesting improved corneal shape.
Corneal collagen crosslinking significantly reduced corneal and ocular higher-order aberrations at 1 year, suggesting improved corneal shape.
Corneal collagen crosslinking significantly reduced corneal and ocular higher-order aberrations at 1 year, suggesting improved corneal shape.
Adding transepithelial corneal collagen cross-linking to intracorneal ring surgery improved vision and reduced spherical refractive error more than ring surgery alone.
Adding transepithelial corneal collagen cross-linking to intracorneal ring surgery improved vision and reduced spherical refractive error more than ring surgery alone.
An exercise program (10,000 steps plus jumps) decreased bone resorption markers and increased bone mineral density over 6 months in premenopausal women.
An exercise program (10,000 steps plus jumps) decreased bone resorption markers and increased bone mineral density over 6 months in premenopausal women.
An exercise program (10,000 steps plus jumps) decreased bone resorption markers and increased bone mineral density over 6 months in premenopausal women.
Using cold (4°C) riboflavin during corneal cross-linking significantly reduced early postoperative pain and related symptoms versus room-temperature riboflavin.
Using cold (4°C) riboflavin during corneal cross-linking significantly reduced early postoperative pain and related symptoms versus room-temperature riboflavin.
Using cold (4°C) riboflavin during corneal cross-linking significantly reduced early postoperative pain and related symptoms versus room-temperature riboflavin.
A topical ω-3 fatty acid microemulsion after epi-off corneal cross-linking sped nerve fiber regeneration and improved symptoms faster than hyaluronic acid alone.
A topical ω-3 fatty acid microemulsion after epi-off corneal cross-linking sped nerve fiber regeneration and improved symptoms faster than hyaluronic acid alone.
A topical ω-3 fatty acid microemulsion after epi-off corneal cross-linking sped nerve fiber regeneration and improved symptoms faster than hyaluronic acid alone.
Corneal collagen cross-linking halted progression of keratoconus over 3 years, flattening Kmax and improving visual acuity compared with controls.
Corneal collagen cross-linking halted progression of keratoconus over 3 years, flattening Kmax and improving visual acuity compared with controls.
Both techniques with acellular dermal matrix improved root coverage; coronally positioned flap gave higher mean coverage than the tunnel technique at 4 months.
Durasphere and bovine collagen produced equivalent improvements in continence at 12 months, with Durasphere requiring less injected volume.
Durasphere and bovine collagen produced equivalent improvements in continence at 12 months, with Durasphere requiring less injected volume.
After corneal collagen crosslinking, high‑molecular‑weight hyaluronic acid eye drops accelerated nerve regeneration and faster recovery of corneal sensitivity compared with low‑molecular‑weight HA or no tears.
After corneal collagen crosslinking, high‑molecular‑weight hyaluronic acid eye drops accelerated nerve regeneration and faster recovery of corneal sensitivity compared with low‑molecular‑weight HA or no tears.
After corneal collagen crosslinking, high‑molecular‑weight hyaluronic acid eye drops accelerated nerve regeneration and faster recovery of corneal sensitivity compared with low‑molecular‑weight HA or no tears.
Topical high‑molecular‑weight hyaluronic acid after third molar extraction reduced local inflammatory cell infiltration and increased angiogenesis at 1 week, with no change in pain or oxidative stress markers at that time point.
Topical high‑molecular‑weight hyaluronic acid after third molar extraction reduced local inflammatory cell infiltration and increased angiogenesis at 1 week, with no change in pain or oxidative stress markers at that time point.
Collagen-impregnated polyester grafts had slightly lower 2-year primary patency than saphenous vein, but differences were not statistically significant.
Collagen-impregnated polyester grafts had slightly lower 2-year primary patency than saphenous vein, but differences were not statistically significant.
Collagen-impregnated polyester grafts had slightly lower 2-year primary patency than saphenous vein, but differences were not statistically significant.
After corneal collagen crosslinking the cornea thinned at 1 month then partially recovered; at 12 months apex and pupil-center thickness returned to baseline but the thinnest pachymetry remained slightly decreased.
After corneal collagen crosslinking the cornea thinned at 1 month then partially recovered; at 12 months apex and pupil-center thickness returned to baseline but the thinnest pachymetry remained slightly decreased.
After corneal collagen crosslinking the cornea thinned at 1 month then partially recovered; at 12 months apex and pupil-center thickness returned to baseline but the thinnest pachymetry remained slightly decreased.
Autologous myoblast/fibroblast injections cured most patients with stress urinary incontinence, whereas collagen injections cured only two patients.
Autologous myoblast/fibroblast injections cured most patients with stress urinary incontinence, whereas collagen injections cured only two patients.
Autologous myoblast/fibroblast injections cured most patients with stress urinary incontinence, whereas collagen injections cured only two patients.
Corneal collagen crosslinking effectively reduced progression of keratoconus over 5 years, with treated eyes showing decreased keratometry compared to progression in control eyes.
Corneal collagen crosslinking effectively reduced progression of keratoconus over 5 years, with treated eyes showing decreased keratometry compared to progression in control eyes.
Patients reported improvements in several subjective visual symptoms (night driving, reading, diplopia, glare, halo, starbursts, foreign-body sensation) one year after corneal collagen crosslinking.
Patients reported improvements in several subjective visual symptoms (night driving, reading, diplopia, glare, halo, starbursts, foreign-body sensation) one year after corneal collagen crosslinking.
Patients reported improvements in several subjective visual symptoms (night driving, reading, diplopia, glare, halo, starbursts, foreign-body sensation) one year after corneal collagen crosslinking.
26 participants in a 10-week resistance training study; a multi-ingredient supplement (including calcium citrate) increased type II muscle fiber size more than collagen, with similar satellite cell content.
26 participants in a 10-week resistance training study; a multi-ingredient supplement (including calcium citrate) increased type II muscle fiber size more than collagen, with similar satellite cell content.
26 participants in a 10-week resistance training study; a multi-ingredient supplement (including calcium citrate) increased type II muscle fiber size more than collagen, with similar satellite cell content.
Randomized trial comparing two acellular dermal matrices (both collagen-containing) found no difference in overall reconstructive failure or patient-reported outcomes; AlloDerm associated with higher seroma odds.
Insertion of Gentacoll (collagen sponge with gentamicin) after mastectomy reduced infections, seromas, drainage volumes and hospital stay versus control.
Randomized trial comparing two acellular dermal matrices (both collagen-containing) found no difference in overall reconstructive failure or patient-reported outcomes; AlloDerm associated with higher seroma odds.
Randomized trial comparing two acellular dermal matrices (both collagen-containing) found no difference in overall reconstructive failure or patient-reported outcomes; AlloDerm associated with higher seroma odds.
Randomized trial found a sheet-type absorbable topical collagen hemostat reduced postoperative pulmonary fistula incidence compared with a combined fibrin-glue-based approach.
Randomized trial found a sheet-type absorbable topical collagen hemostat reduced postoperative pulmonary fistula incidence compared with a combined fibrin-glue-based approach.
Dissolvable collagen punctal plugs in 62 patients with aqueous-deficient dry eye reduced symptoms and increased tear stability and volume within 12 days.
Dissolvable collagen punctal plugs in 62 patients with aqueous-deficient dry eye reduced symptoms and increased tear stability and volume within 12 days.
Dissolvable collagen punctal plugs in 62 patients with aqueous-deficient dry eye reduced symptoms and increased tear stability and volume within 12 days.
A single teriparatide injection caused short-term changes in calcium metabolism and biphasic changes in bone turnover markers; vitamin D metabolites (1,25(OH)2D) rose transiently but Vitamin D was not the intervention.
Adding calcitriol to esomeprazole did not improve bone mineral density; only minor changes in calcium and bone markers were observed.
Matched serum and tissue from UNIFI trial patients (n=97) show specific serum collagen fragments (C1M, Pro-Collagen 22, CTX-III, ELP-3) correlate with intestinal inflammatory-activated fibroblasts and change with ustekinumab response.
Matched serum and tissue from UNIFI trial patients (n=97) show specific serum collagen fragments (C1M, Pro-Collagen 22, CTX-III, ELP-3) correlate with intestinal inflammatory-activated fibroblasts and change with ustekinumab response.
Matched serum and tissue from UNIFI trial patients (n=97) show specific serum collagen fragments (C1M, Pro-Collagen 22, CTX-III, ELP-3) correlate with intestinal inflammatory-activated fibroblasts and change with ustekinumab response.
Split-face trial in which hyaluronic acid fillers improved nasolabial/crow's-feet wrinkles and showed increased local collagen synthesis and good tolerability up to 180 days.
In 50 patients randomized to ACHA versus Restylane, the amino-acid cross-linked HA filler promoted dermal fibroblast activity, increased skin thickness and collagen generation and provided longer-lasting volume.
In 50 patients randomized to ACHA versus Restylane, the amino-acid cross-linked HA filler promoted dermal fibroblast activity, increased skin thickness and collagen generation and provided longer-lasting volume.
Randomized controlled trial (161 patients) found that adding a gentamicin-containing collagen sponge (Collatamp®) to pilonidal excision with primary suture did not significantly change wound infection rates, wound healing, or recurrence at 1 year.
In children with partial-thickness burns, collagenase ointment and silver sulfadiazine produced similar clinical outcomes and need for grafting; collagenase had more wound infections (trend) and higher product cost.
Implanting a gentamycin-containing collagen sponge under the wound did not reduce wound infection after ileostomy closure compared with an identical collagen sponge without antibiotic.
Randomized controlled trial (161 patients) found that adding a gentamicin-containing collagen sponge (Collatamp®) to pilonidal excision with primary suture did not significantly change wound infection rates, wound healing, or recurrence at 1 year.
Randomized controlled trial (161 patients) found that adding a gentamicin-containing collagen sponge (Collatamp®) to pilonidal excision with primary suture did not significantly change wound infection rates, wound healing, or recurrence at 1 year.
Sealing extraction sockets with a porcine collagen matrix gave similar 1-year implant and bone outcomes as connective tissue graft, avoiding a donor site.
Sealing extraction sockets with a porcine collagen matrix gave similar 1-year implant and bone outcomes as connective tissue graft, avoiding a donor site.
Adding autogenous bone (with or without bioactive glass) to a collagen membrane led to greater periodontal defect healing than collagen membrane alone.
In periodontal intraosseous defects, adding a collagen membrane to enamel matrix protein therapy did not improve clinical or radiographic outcomes compared with either therapy alone.
In people recovering from COVID-19, intramuscular polymerised type I collagen reduced inflammatory markers and sped systemic recovery of physiological networks, with stronger effects in women.
In people recovering from COVID-19, intramuscular polymerised type I collagen reduced inflammatory markers and sped systemic recovery of physiological networks, with stronger effects in women.
Corneal cross-linking (riboflavin+UVA) slowed progression of keratoconus (flattened Kmax) but caused more transient corneal haze and epithelial erosions.
Corneal cross-linking (riboflavin+UVA) slowed progression of keratoconus (flattened Kmax) but caused more transient corneal haze and epithelial erosions.
After tooth extraction, placement of deproteinized bovine bone mineral (with or without adjuncts) reduced buccal contour loss compared with no treatment, but overall differences among tested modalities were not statistically significant.
After tooth extraction, placement of deproteinized bovine bone mineral (with or without adjuncts) reduced buccal contour loss compared with no treatment, but overall differences among tested modalities were not statistically significant.
Using a resorbable collagen membrane with primary closure after lower third molar extraction improved distal alveolar bone level of the adjacent second molar and improved periodontal measures compared with secondary closure.
Using a resorbable collagen membrane with primary closure after lower third molar extraction improved distal alveolar bone level of the adjacent second molar and improved periodontal measures compared with secondary closure.
Ancillary analysis measuring preoperative vitamin D showed vitamin D levels had low predictive accuracy for mid-urethral sling surgical success; urinary NTx was a better predictor.
In multiple adjacent gingival recessions, xenogenic collagen matrix reduced surgical time and sped patient recovery but provided less root coverage and keratinized tissue gain than autologous connective tissue graft.
In multiple adjacent gingival recessions, xenogenic collagen matrix reduced surgical time and sped patient recovery but provided less root coverage and keratinized tissue gain than autologous connective tissue graft.
In multiple adjacent gingival recessions, xenogenic collagen matrix reduced surgical time and sped patient recovery but provided less root coverage and keratinized tissue gain than autologous connective tissue graft.
Randomized trial of 60 implants comparing synthetic PLA vs collagen membranes with biphasic calcium phosphate graft: similar facial bone thickness loss at 6 months and all implants osseointegrated.
Treatment of venous leg ulcers with an ORC/collagen matrix significantly reduced protease activities in wound exudate compared with standard care over 12 weeks.
Treatment of venous leg ulcers with an ORC/collagen matrix significantly reduced protease activities in wound exudate compared with standard care over 12 weeks.
Treatment of venous leg ulcers with an ORC/collagen matrix significantly reduced protease activities in wound exudate compared with standard care over 12 weeks.
Treatment of venous leg ulcers with an ORC/collagen matrix significantly reduced protease activities in wound exudate compared with standard care over 12 weeks.
In 27 children, halving inhaled steroid dose and adding formoterol sped short-term leg growth and increased collagen turnover markers without worsening asthma control.
Randomized trial (n=28) comparing collagen matrix seal vs collagen sponge with bone allograft for alveolar ridge preservation found both materials minimized ridge resorption with no significant differences.
Randomized trial (n=28) comparing collagen matrix seal vs collagen sponge with bone allograft for alveolar ridge preservation found both materials minimized ridge resorption with no significant differences.
Randomized trial (n=28) comparing collagen matrix seal vs collagen sponge with bone allograft for alveolar ridge preservation found both materials minimized ridge resorption with no significant differences.
Women who previously received zoledronate had higher BMD and persistently lower bone turnover markers over 5 years compared with controls.
Women who previously received zoledronate had higher BMD and persistently lower bone turnover markers over 5 years compared with controls.
Women who previously received zoledronate had higher BMD and persistently lower bone turnover markers over 5 years compared with controls.
Use of a porcine collagen (Pelvicol) implant at anterior repair reduced anatomical anterior prolapse recurrence at 1 year compared with repair alone.
Use of a porcine collagen (Pelvicol) implant at anterior repair reduced anatomical anterior prolapse recurrence at 1 year compared with repair alone.
All cemented prosthesis designs led to early proximal femoral bone loss and transient increases in bone turnover markers; patterns were similar across designs.
Oral risedronate increased lumbar spine BMD and reduced clinical fractures in children with osteogenesis imperfecta at 1 year.
Oral risedronate increased lumbar spine BMD and reduced clinical fractures in children with osteogenesis imperfecta at 1 year.
RGTA eye drops after epi-off CXL sped corneal epithelial healing and reduced ocular symptoms faster than control.
RGTA eye drops after epi-off CXL sped corneal epithelial healing and reduced ocular symptoms faster than control.
RGTA eye drops after epi-off CXL sped corneal epithelial healing and reduced ocular symptoms faster than control.
Adding a collagen–elastin dermal matrix (Matriderm) to skin grafts improved nasal-tip contour versus full-thickness grafts, but two fistulae occurred in the Matriderm group.
Adding a collagen–elastin dermal matrix (Matriderm) to skin grafts improved nasal-tip contour versus full-thickness grafts, but two fistulae occurred in the Matriderm group.
Two non‑surgical treatments (fractional radiofrequency and microneedling) improved vulvar appearance and symptoms and increased markers of collagen remodeling.
Two non‑surgical treatments (fractional radiofrequency and microneedling) improved vulvar appearance and symptoms and increased markers of collagen remodeling.
Two non‑surgical treatments (fractional radiofrequency and microneedling) improved vulvar appearance and symptoms and increased markers of collagen remodeling.
Two corneal cross-linking procedures stabilized keratoconus over 12 months with modest differences; iontophoresis transepithelial treatment gave significant visual gains but slightly less corneal flattening than standard protocol.
Immediate implants with platform switching and grafting (including bovine bone + collagen) showed less early crestal bone loss than controls.
Immediate implants with platform switching and grafting (including bovine bone + collagen) showed less early crestal bone loss than controls.
In high‑risk vascular foot wounds, topical negative pressure showed greater reduction in wound depth at 14 days but no significant difference in wound volume or hydroxyproline (collagen surrogate).
In high‑risk vascular foot wounds, topical negative pressure showed greater reduction in wound depth at 14 days but no significant difference in wound volume or hydroxyproline (collagen surrogate).
In high‑risk vascular foot wounds, topical negative pressure showed greater reduction in wound depth at 14 days but no significant difference in wound volume or hydroxyproline (collagen surrogate).
Implantation of a gentamicin‑collagen product into the pelvic cavity reduced organ‑space surgical site infection when anastomotic leakage did not occur.
Implantation of a gentamicin‑collagen product into the pelvic cavity reduced organ‑space surgical site infection when anastomotic leakage did not occur.
In periodontitis patients, EDTA root etching increased doxycycline availability from a biodegradable collagen membrane compared with membrane alone.
In periodontitis patients, EDTA root etching increased doxycycline availability from a biodegradable collagen membrane compared with membrane alone.
In hypertensive patients with heart failure, higher circulating collagen turnover markers were associated with lower left ventricular twist, suggesting loss of myocardial collagen scaffolding is linked to impaired deformation.
In hypertensive patients with heart failure, higher circulating collagen turnover markers were associated with lower left ventricular twist, suggesting loss of myocardial collagen scaffolding is linked to impaired deformation.
In hypertensive patients with heart failure, higher circulating collagen turnover markers were associated with lower left ventricular twist, suggesting loss of myocardial collagen scaffolding is linked to impaired deformation.
Prospective randomized (non-blinded) trial comparing autogenous demineralized dentin matrix with bio-collagen membrane versus natural healing after lower third molar extraction; test group showed better probing depth and radiographic bone density but slightly greater early swelling.
Orthodontic force increased markers in gum tissue and fluid over 4 weeks (higher force → higher marker levels).
Orthodontic force increased markers in gum tissue and fluid over 4 weeks (higher force → higher marker levels).
Orthodontic force increased markers in gum tissue and fluid over 4 weeks (higher force → higher marker levels).
In patients at risk of heart failure, spironolactone reduced left atrial volume index and NT-proBNP mainly in those with biomarkers indicating lower collagen cross-linking.
In patients at risk of heart failure, spironolactone reduced left atrial volume index and NT-proBNP mainly in those with biomarkers indicating lower collagen cross-linking.
In patients at risk of heart failure, spironolactone reduced left atrial volume index and NT-proBNP mainly in those with biomarkers indicating lower collagen cross-linking.
Collagen-containing bone grafts showed slightly less buccal soft-tissue loss at 6 months vs other treatments, but differences were not statistically significant.
In 104 patients undergoing deep sclerectomy, adding a collagen implant improved long-term intraocular pressure control, increased success rates, and reduced need for glaucoma medications over ~44 months.
Using bovine porous bone mineral plus a porcine-derived collagen membrane led to greater pocket-depth reduction, attachment gain, and defect fill vs flap debridement at 6 months.
Using bovine porous bone mineral plus a porcine-derived collagen membrane led to greater pocket-depth reduction, attachment gain, and defect fill vs flap debridement at 6 months.
Using bovine porous bone mineral plus a porcine-derived collagen membrane led to greater pocket-depth reduction, attachment gain, and defect fill vs flap debridement at 6 months.
Placing a gentamicin-containing collagen sponge into the wound after pilonidal sinus surgery sped healing and reduced infections and recurrences compared with oral antibiotics alone.
Collagen-coated transvaginal mesh gave a much higher objective cure rate for anterior wall prolapse at 12 months but had notable mesh exposure complications.
Collagen-coated transvaginal mesh gave a much higher objective cure rate for anterior wall prolapse at 12 months but had notable mesh exposure complications.
Collagen-coated transvaginal mesh gave a much higher objective cure rate for anterior wall prolapse at 12 months but had notable mesh exposure complications.
Use of a lateral collagen meniscus implant improved function, activity and pain scores over 2 years in patients with partial lateral meniscal defects, with some device-related adverse events in a minority.
Use of a lateral collagen meniscus implant improved function, activity and pain scores over 2 years in patients with partial lateral meniscal defects, with some device-related adverse events in a minority.
Use of a lateral collagen meniscus implant improved function, activity and pain scores over 2 years in patients with partial lateral meniscal defects, with some device-related adverse events in a minority.
Corneal crosslinking sometimes increased corneal rigidity as measured by a Schiøtz tonometer, but results were operator-dependent and variable.
Corneal crosslinking sometimes increased corneal rigidity as measured by a Schiøtz tonometer, but results were operator-dependent and variable.
Collagen-coated Dacron aortic grafts had similar long-term patency and complication rates to gelatine-coated Dacron and PTFE grafts over ~8 years.
Collagen-coated Dacron aortic grafts had similar long-term patency and complication rates to gelatine-coated Dacron and PTFE grafts over ~8 years.
Both HA/collagen (Biostite) and bovine HA (Bio-Oss) grafts produced similar, significant improvements in pocket depth, clinical attachment, and defect fill at 12 months.
Both HA/collagen (Biostite) and bovine HA (Bio-Oss) grafts produced similar, significant improvements in pocket depth, clinical attachment, and defect fill at 12 months.
Porcine-derived xenograft showed equal or better dimensional stability than bovine-derived xenograft in horizontal ridge augmentation and socket preservation at 6 months.
Porcine-derived xenograft showed equal or better dimensional stability than bovine-derived xenograft in horizontal ridge augmentation and socket preservation at 6 months.
Porcine-derived xenograft showed equal or better dimensional stability than bovine-derived xenograft in horizontal ridge augmentation and socket preservation at 6 months.
Randomized patients received prostheses coated with gelatin, collagen (Hemashield), or albumin; no significant differences in patency or late complications over 5 years.
Randomized patients received prostheses coated with gelatin, collagen (Hemashield), or albumin; no significant differences in patency or late complications over 5 years.
Randomized patients received prostheses coated with gelatin, collagen (Hemashield), or albumin; no significant differences in patency or late complications over 5 years.
Using a collagen membrane to cover sinus grafts improved implant survival, particularly for implants loaded at 6–9 months.
Four weeks of daily 10 g porcine collagen did not change overall daytime glucose but raised glucose variability and markers of insulin resistance.
Four weeks of daily 10 g porcine collagen did not change overall daytime glucose but raised glucose variability and markers of insulin resistance.
Four weeks of daily 10 g porcine collagen did not change overall daytime glucose but raised glucose variability and markers of insulin resistance.
Collagen meniscus implant plus osteotomy showed similar clinical scores to osteotomy alone at 2 years, with one implant dislocation reported.
Collagen meniscus implant plus osteotomy showed similar clinical scores to osteotomy alone at 2 years, with one implant dislocation reported.
In 104 patients undergoing deep sclerectomy, adding a collagen implant improved long-term intraocular pressure control, increased success rates, and reduced need for glaucoma medications over ~44 months.
In 104 patients undergoing deep sclerectomy, adding a collagen implant improved long-term intraocular pressure control, increased success rates, and reduced need for glaucoma medications over ~44 months.
In 96 active adults with activity-related knee discomfort, 40 mg daily undenatured type II collagen (UC-II) for 24 weeks modestly improved knee flexion range of motion versus placebo and was well tolerated.
In 96 active adults with activity-related knee discomfort, 40 mg daily undenatured type II collagen (UC-II) for 24 weeks modestly improved knee flexion range of motion versus placebo and was well tolerated.
Oral bovine type I collagen did not improve skin scores overall in diffuse cutaneous systemic sclerosis, but a late-phase subgroup showed greater skin score improvement at month 15.
In 96 active adults with activity-related knee discomfort, 40 mg daily undenatured type II collagen (UC-II) for 24 weeks modestly improved knee flexion range of motion versus placebo and was well tolerated.
In healthy adults, 8 weeks of high-dose simvastatin (80 mg/day) lowered a serum bone formation marker but did not change a urinary collagen resorption marker.
Endoscopic collagen injections provided little improvement for stress urinary incontinence compared with autologous cell injections; most women treated with collagen remained incontinent at 12 months.
Endoscopic collagen injections provided little improvement for stress urinary incontinence compared with autologous cell injections; most women treated with collagen remained incontinent at 12 months.
Endoscopic collagen injections provided little improvement for stress urinary incontinence compared with autologous cell injections; most women treated with collagen remained incontinent at 12 months.
Biopsies from extraction sockets (some augmented with Bio-Oss collagen) showed peak osteoblastic activity at 4 weeks with reduced mature osteoblast markers and vascularity by 12 weeks.
Biopsies from extraction sockets (some augmented with Bio-Oss collagen) showed peak osteoblastic activity at 4 weeks with reduced mature osteoblast markers and vascularity by 12 weeks.
Biopsies from extraction sockets (some augmented with Bio-Oss collagen) showed peak osteoblastic activity at 4 weeks with reduced mature osteoblast markers and vascularity by 12 weeks.
Use of a gentamicin-impregnated collagen sponge after marsupialization did not reduce infection, hemorrhage, or healing time compared with control.
Use of a gentamicin-impregnated collagen sponge after marsupialization did not reduce infection, hemorrhage, or healing time compared with control.
Collagen implants in deep sclerectomy produced intraocular pressure lowering and medication reduction comparable to a PMMA implant—no significant differences between implants.
Randomized study of nonpenetrating deep sclerectomy with a collagen implant, comparing adjunctive mitomycin C versus no MMC in glaucoma patients.
Collagen implants in deep sclerectomy produced intraocular pressure lowering and medication reduction comparable to a PMMA implant—no significant differences between implants.
In 77 men with bone-metastatic prostate cancer on zoledronic acid, most bone turnover markers fell after treatment; several markers were higher in patients with progressive bone disease.
In 45 postmenopausal osteopenic women, a 12-week supervised walking program improved function and increased bone turnover markers (P1NP, CTX) with osteocalcin rising in the exercise group; both groups received vitamin D and calcium.
In 27 children, halving inhaled steroid dose and adding formoterol sped short-term leg growth and increased collagen turnover markers without worsening asthma control.
In 27 children, halving inhaled steroid dose and adding formoterol sped short-term leg growth and increased collagen turnover markers without worsening asthma control.
In 50 elderly men, 6 months of raloxifene showed no overall change in bone turnover or lipids, but reductions in urinary type I collagen NTX occurred in a subset with low baseline estradiol.
In 50 elderly men, 6 months of raloxifene showed no overall change in bone turnover or lipids, but reductions in urinary type I collagen NTX occurred in a subset with low baseline estradiol.
In patients with diabetic foot ulcers, topical collagen/ORC/silver increased early healing responders and reduced withdrawals for infection versus standard care.
In patients with diabetic foot ulcers, topical collagen/ORC/silver increased early healing responders and reduced withdrawals for infection versus standard care.
In patients with diabetic foot ulcers, topical collagen/ORC/silver increased early healing responders and reduced withdrawals for infection versus standard care.
In 40 patients undergoing sinus augmentation, covering the lateral window with a collagen membrane produced comparable bone formation, surgical outcomes, and patient discomfort to bony wall repositioning.
In 144 randomized patients, chondrocyte implantation on a porcine collagen membrane (MACI) produced sustained superior pain and function outcomes at 5 years versus microfracture for symptomatic knee cartilage defects.
In 144 randomized patients, chondrocyte implantation on a porcine collagen membrane (MACI) produced sustained superior pain and function outcomes at 5 years versus microfracture for symptomatic knee cartilage defects.
In 144 randomized patients, chondrocyte implantation on a porcine collagen membrane (MACI) produced sustained superior pain and function outcomes at 5 years versus microfracture for symptomatic knee cartilage defects.
Stentoplasty using resorbable calcium-salt bone fillers in older adults with a single vertebral compression fracture reduced pain and disability and promoted bone formation over 3 years, with slight early loss of restored vertebral height.
Stentoplasty using resorbable calcium-salt bone fillers in older adults with a single vertebral compression fracture reduced pain and disability and promoted bone formation over 3 years, with slight early loss of restored vertebral height.
Randomized double-blind pilot trial in men with 20–30% TBSA burns testing an oral hydrolyzed collagen supplement versus isocaloric placebo for 4 weeks; supplement improved markers and wound-healing rate.
Randomized double-blind pilot trial in men with 20–30% TBSA burns testing an oral hydrolyzed collagen supplement versus isocaloric placebo for 4 weeks; supplement improved markers and wound-healing rate.
Prospective randomized trial comparing collagen versus silicone punctal plugs for dry eye; both plug types produced similar short-term improvements in tear metrics and retention.
Prospective randomized trial comparing collagen versus silicone punctal plugs for dry eye; both plug types produced similar short-term improvements in tear metrics and retention.
Prospective randomized trial comparing collagen versus silicone punctal plugs for dry eye; both plug types produced similar short-term improvements in tear metrics and retention.
Clinical study evaluating a single topical device composed of 95% collagen + 5% metronidazole as adjunct to debridement in adult periodontitis patients, showing reductions in several microbial measures.
Clinical study evaluating a single topical device composed of 95% collagen + 5% metronidazole as adjunct to debridement in adult periodontitis patients, showing reductions in several microbial measures.
Clinical study evaluating a single topical device composed of 95% collagen + 5% metronidazole as adjunct to debridement in adult periodontitis patients, showing reductions in several microbial measures.
Randomized comparative study (n=45; 3 groups of 15) testing periodontal dressings: collagen dressing showed greater symptomatic relief and improved clinical wound-healing indices versus light-cure and non-eugenol dressings.
Using deproteinised bovine bone mineral plus a resorbable collagen membrane after impacted third molar extraction improved alveolar bone dimensions and periodontal status versus natural healing.
Randomized comparative study (n=45; 3 groups of 15) testing periodontal dressings: collagen dressing showed greater symptomatic relief and improved clinical wound-healing indices versus light-cure and non-eugenol dressings.
Comparative clinical study (1-year) showing collagen-containing regenerative technique (CPRT) achieved high root coverage and increased gingival thickness versus GTR.
Comparative clinical study (1-year) showing collagen-containing regenerative technique (CPRT) achieved high root coverage and increased gingival thickness versus GTR.
Comparative clinical study (1-year) showing collagen-containing regenerative technique (CPRT) achieved high root coverage and increased gingival thickness versus GTR.
In periodontal intraosseous defects, adding a collagen membrane to enamel matrix protein therapy did not improve clinical or radiographic outcomes compared with either therapy alone.
Collagen hemostatic sponge reduced postoperative bleeding, transfusions, and hospital stay versus gelatin sponge; topical TXA reduced bleeding more than collagen.
Collagen hemostatic sponge reduced postoperative bleeding, transfusions, and hospital stay versus gelatin sponge; topical TXA reduced bleeding more than collagen.
In adults with gastric ulcer, adding hydrotalcite to esomeprazole improved tissue maturity with greater collagen deposition and markers of angiogenesis versus esomeprazole alone.
In adults with gastric ulcer, adding hydrotalcite to esomeprazole improved tissue maturity with greater collagen deposition and markers of angiogenesis versus esomeprazole alone.
In adults with gastric ulcer, adding hydrotalcite to esomeprazole improved tissue maturity with greater collagen deposition and markers of angiogenesis versus esomeprazole alone.
Randomized trial of two whole-body vibration frequencies (20 Hz vs 30 Hz) in chronic stroke patients; both increased knee strength and reduced bone resorption (NTx), with 30 Hz showing greater paretic eccentric strength gains.
In patients with open-angle glaucoma, very deep sclerectomy with a collagen implant provided good IOP control similar to standard deep sclerectomy over 2 years, with lower day-1 IOP in the very deep method.
In patients with open-angle glaucoma, very deep sclerectomy with a collagen implant provided good IOP control similar to standard deep sclerectomy over 2 years, with lower day-1 IOP in the very deep method.
In this phase II randomized trial, oltipraz treatment showed no significant overall histological benefit versus placebo, though the 60 mg bid group showed a trend toward decreased hepatic collagen area and plasma TGF-β1 that correlated with histologic improvement.
In this phase II randomized trial, oltipraz treatment showed no significant overall histological benefit versus placebo, though the 60 mg bid group showed a trend toward decreased hepatic collagen area and plasma TGF-β1 that correlated with histologic improvement.
In this phase II randomized trial, oltipraz treatment showed no significant overall histological benefit versus placebo, though the 60 mg bid group showed a trend toward decreased hepatic collagen area and plasma TGF-β1 that correlated with histologic improvement.
Adding prophylactic high-fluence corneal collagen crosslinking to high-myopic LASIK improved refractive and keratometric stability over two years compared with LASIK alone.
Adding prophylactic high-fluence corneal collagen crosslinking to high-myopic LASIK improved refractive and keratometric stability over two years compared with LASIK alone.
Adding prophylactic high-fluence corneal collagen crosslinking to high-myopic LASIK improved refractive and keratometric stability over two years compared with LASIK alone.
In this randomized, double-blind trial, MAL plus red light increased dermal thickness and showed trends toward improved collagen and elastic tissue histology in photodamaged facial skin, though between-group differences were often non-significant, possibly due to low power.
In this randomized, double-blind trial, MAL plus red light increased dermal thickness and showed trends toward improved collagen and elastic tissue histology in photodamaged facial skin, though between-group differences were often non-significant, possibly due to low power.
In patients with active rheumatoid arthritis, oral chicken type II collagen (CCII) was effective but less so than methotrexate (MTX) over 24 weeks and was associated with fewer and milder adverse events.
In patients with active rheumatoid arthritis, oral chicken type II collagen (CCII) was effective but less so than methotrexate (MTX) over 24 weeks and was associated with fewer and milder adverse events.
Use of a collagen membrane (Bio-Gide) in ridge augmentation did not meaningfully change marginal gingiva or marginal bone levels or implant survival during the first year.
Use of a collagen membrane (Bio-Gide) in ridge augmentation did not meaningfully change marginal gingiva or marginal bone levels or implant survival during the first year.
Adding atelocollagen to arthroscopic microfracture improved MRI-assessed cartilage quality and yielded hyaline-like cartilage with abundant type II collagen; pain and functional scores improved in both groups with no significant between-group clinical differences at 2 years.
Adding atelocollagen to arthroscopic microfracture improved MRI-assessed cartilage quality and yielded hyaline-like cartilage with abundant type II collagen; pain and functional scores improved in both groups with no significant between-group clinical differences at 2 years.
Adding atelocollagen to arthroscopic microfracture improved MRI-assessed cartilage quality and yielded hyaline-like cartilage with abundant type II collagen; pain and functional scores improved in both groups with no significant between-group clinical differences at 2 years.
In women taking monophasic oral contraceptives, a transient decrease in a type I collagen synthesis marker (PICP) was observed with the lower-ethinyl-estradiol formulation after three cycles and normalized by six months; degradation marker (ICTP) was unchanged.
Oral and transdermal postmenopausal estrogen therapy decreased a urine cartilage-degradation marker (uCTX-II) by ~19–30% after 1 year and strongly suppressed bone resorption marker (uCTX-I), suggesting protective effects on cartilage and bone.
Oral and transdermal postmenopausal estrogen therapy decreased a urine cartilage-degradation marker (uCTX-II) by ~19–30% after 1 year and strongly suppressed bone resorption marker (uCTX-I), suggesting protective effects on cartilage and bone.
Oral and transdermal postmenopausal estrogen therapy decreased a urine cartilage-degradation marker (uCTX-II) by ~19–30% after 1 year and strongly suppressed bone resorption marker (uCTX-I), suggesting protective effects on cartilage and bone.
Using deproteinized bovine bone with 10% collagen plus collagen membrane (test) after molar/premolar extraction preserved ridge width and vertical bone better than natural healing at 4 months.
Using deproteinized bovine bone with 10% collagen plus collagen membrane (test) after molar/premolar extraction preserved ridge width and vertical bone better than natural healing at 4 months.
Using deproteinized bovine bone with 10% collagen plus collagen membrane (test) after molar/premolar extraction preserved ridge width and vertical bone better than natural healing at 4 months.
At 6 months, resorbable collagen membranes showed greater buccal bone loss (~0.8 mm) but an accompanying soft tissue thickness gain (~+0.6 mm) compared with non-resorbable membranes (bone ~0.1 mm loss, soft tissue ~0.0 mm).
At 6 months, resorbable collagen membranes showed greater buccal bone loss (~0.8 mm) but an accompanying soft tissue thickness gain (~+0.6 mm) compared with non-resorbable membranes (bone ~0.1 mm loss, soft tissue ~0.0 mm).
At 6 months, resorbable collagen membranes showed greater buccal bone loss (~0.8 mm) but an accompanying soft tissue thickness gain (~+0.6 mm) compared with non-resorbable membranes (bone ~0.1 mm loss, soft tissue ~0.0 mm).
Small prospective study found better healing of through-and-through lesions when GTR with bovine bone plus a collagen membrane was used.
Small prospective study found better healing of through-and-through lesions when GTR with bovine bone plus a collagen membrane was used.
Randomized trial in periodontitis patients showed similar pocket depth and attachment gains for both barriers but greater bone fill with the collagen membrane at 6 months.
In elderly sedentary men, recreational football increased proximal femur BMD and markers of bone formation and turnover over 12 months.
In elderly sedentary men, recreational football increased proximal femur BMD and markers of bone formation and turnover over 12 months.
Single 1000 mg calcium dose from milk or calcium carbonate acutely reduced bone resorption (CTX-1) and lowered PTH in postmenopausal women regardless of visceral fat.
Randomized study in metastatic bone disease showed greater symptomatic pain improvement and suppression of biochemical bone resorption with IV pamidronate versus oral clodronate.
Randomized study in metastatic bone disease showed greater symptomatic pain improvement and suppression of biochemical bone resorption with IV pamidronate versus oral clodronate.
Infliximab induction increased markers of bone formation and resorption in children with Crohn's disease and these changes associated with improved growth and disease activity.
Split-mouth randomized study in 40 patients comparing scaling/root planing alone versus adjunctive collagen-based tetracycline fibers for chronic periodontitis over 3 months.
Oral chicken type II collagen (0.1 mg/day) reduced pain, stiffness and joint counts in RA patients but was less effective than methotrexate and had fewer/milder side effects.
Oral chicken type II collagen (0.1 mg/day) reduced pain, stiffness and joint counts in RA patients but was less effective than methotrexate and had fewer/milder side effects.
Adding native/hydrolyzed collagen to a combo of CS/GL/MSM/HA produced larger pain reductions and better function than the same regimen without collagen in knee OA exacerbations.
Adding native/hydrolyzed collagen to a combo of CS/GL/MSM/HA produced larger pain reductions and better function than the same regimen without collagen in knee OA exacerbations.
Use of a dual anti-collagen membrane for guided tissue regeneration produced greater 1-year clinical attachment gains and bone density increases than an atelocollagen membrane; results were stable to 6 years.
Use of a dual anti-collagen membrane for guided tissue regeneration produced greater 1-year clinical attachment gains and bone density increases than an atelocollagen membrane; results were stable to 6 years.
Deep sclerectomy with a collagen implant produced lower early post-operative anterior chamber inflammation than standard trabeculectomy, with significant differences up to 1 month.
Deep sclerectomy with a collagen implant produced lower early post-operative anterior chamber inflammation than standard trabeculectomy, with significant differences up to 1 month.
A native collagen membrane produced similar vertical bone fill and soft-tissue outcomes to a synthetic PEG membrane at 6 months and 18 months; differences were not statistically significant and non-inferiority was not conclusively demonstrated.
A native collagen membrane produced similar vertical bone fill and soft-tissue outcomes to a synthetic PEG membrane at 6 months and 18 months; differences were not statistically significant and non-inferiority was not conclusively demonstrated.
A native collagen membrane produced similar vertical bone fill and soft-tissue outcomes to a synthetic PEG membrane at 6 months and 18 months; differences were not statistically significant and non-inferiority was not conclusively demonstrated.
In vitro and two randomized healthy-volunteer trials showed near-complete Lp-PLA2 inhibition but no clinically relevant enhancement of platelet aggregation to collagen, ADP, or PAF.
Randomized double-blind placebo-controlled trial (8 weeks) in 32 patients with grade 1–2 meniscal tears; multi-ingredient product containing type I/III and type II collagen (plus glucosamine, chondroitin, hyaluronic acid, vitamin C) improved pain and several quality-of-life and function scores versus placebo.
Randomized double-blind placebo-controlled trial (8 weeks) in 32 patients with grade 1–2 meniscal tears; multi-ingredient product containing type I/III and type II collagen (plus glucosamine, chondroitin, hyaluronic acid, vitamin C) improved pain and several quality-of-life and function scores versus placebo.
Randomized double-blind placebo-controlled trial (8 weeks) in 32 patients with grade 1–2 meniscal tears; multi-ingredient product containing type I/III and type II collagen (plus glucosamine, chondroitin, hyaluronic acid, vitamin C) improved pain and several quality-of-life and function scores versus placebo.
Randomized 1-year nutrition intervention in older adults comparing twice-daily sachets of whey, collagen hydrolysate, or carbohydrate; collagen supplementation (1.3 µg B12/day) did not change plasma B12, holoTC, or MMA after 12 months compared with baseline.
Randomized 1-year nutrition intervention in older adults comparing twice-daily sachets of whey, collagen hydrolysate, or carbohydrate; collagen supplementation (1.3 µg B12/day) did not change plasma B12, holoTC, or MMA after 12 months compared with baseline.
Randomized 1-year nutrition intervention in older adults comparing twice-daily sachets of whey, collagen hydrolysate, or carbohydrate; collagen supplementation (1.3 µg B12/day) did not change plasma B12, holoTC, or MMA after 12 months compared with baseline.
In PCI patients, using a collagen plug vascular closure device did not change the reduction in major bleeding seen with bivalirudin versus heparin+abciximab.
In PCI patients, using a collagen plug vascular closure device did not change the reduction in major bleeding seen with bivalirudin versus heparin+abciximab.
A collagen corneal shield gave worse device performance and more adverse events than a hydrogel bandage, while pain scores were similar.
A collagen corneal shield gave worse device performance and more adverse events than a hydrogel bandage, while pain scores were similar.
Compared two graft materials after tooth extraction; putty allograft produced more new vital bone than bovine xenograft.
Compared two graft materials after tooth extraction; putty allograft produced more new vital bone than bovine xenograft.
Topical estrogen patches improved wound healing in elderly subjects, increasing collagen and wound strength and reducing inflammation.
Topical estrogen patches improved wound healing in elderly subjects, increasing collagen and wound strength and reducing inflammation.
Topical estrogen patches improved wound healing in elderly subjects, increasing collagen and wound strength and reducing inflammation.
Composite graft using acellular dermal matrix plus thin split-thickness skin improved skin organization, functional scores, and reduced scarring versus skin alone.
Composite graft using acellular dermal matrix plus thin split-thickness skin improved skin organization, functional scores, and reduced scarring versus skin alone.
Composite graft using acellular dermal matrix plus thin split-thickness skin improved skin organization, functional scores, and reduced scarring versus skin alone.
Adding a gentamicin-collagen sponge to standard care increased clinical cure and pathogen eradication rates in moderately infected diabetic foot ulcers.
Adding a gentamicin-collagen sponge to standard care increased clinical cure and pathogen eradication rates in moderately infected diabetic foot ulcers.
Adding a gentamicin-collagen sponge to standard care increased clinical cure and pathogen eradication rates in moderately infected diabetic foot ulcers.
Implanting acellular dermal matrix at parotidectomy reduced postoperative depressed deformities and markedly reduced Frey's syndrome compared with controls.
Implanting acellular dermal matrix at parotidectomy reduced postoperative depressed deformities and markedly reduced Frey's syndrome compared with controls.
29 healthy volunteers received gelatin-based collagen peptide mixtures (with or without Trp); CP-Trp lowered plasma tryptophan, CP+Trp produced a large increase in plasma tryptophan; no other significant effects on mood or cortisol.
29 healthy volunteers received gelatin-based collagen peptide mixtures (with or without Trp); CP-Trp lowered plasma tryptophan, CP+Trp produced a large increase in plasma tryptophan; no other significant effects on mood or cortisol.
29 healthy volunteers received gelatin-based collagen peptide mixtures (with or without Trp); CP-Trp lowered plasma tryptophan, CP+Trp produced a large increase in plasma tryptophan; no other significant effects on mood or cortisol.
Use of a bovine bone graft plus a bioabsorbable collagen barrier led to greater soft- and hard-tissue improvement than open-flap debridement over the study period.
Use of a bovine bone graft plus a bioabsorbable collagen barrier led to greater soft- and hard-tissue improvement than open-flap debridement over the study period.
Extraction sockets grafted with Bio-Oss Collagen showed less new bone formation at 12 weeks than ungrafted sockets.
Extraction sockets grafted with Bio-Oss Collagen showed less new bone formation at 12 weeks than ungrafted sockets.
Randomized multicenter trial comparing collagen-coated Dacron, gelatin-coated Dacron, and PTFE grafts in abdominal aortic bifurcation surgery; long-term patency similar but infections occurred only with Dacron grafts.
Randomized multicenter trial comparing collagen-coated Dacron, gelatin-coated Dacron, and PTFE grafts in abdominal aortic bifurcation surgery; long-term patency similar but infections occurred only with Dacron grafts.
Randomized multicenter trial comparing collagen-coated Dacron, gelatin-coated Dacron, and PTFE grafts in abdominal aortic bifurcation surgery; long-term patency similar but infections occurred only with Dacron grafts.
In combined surgical therapy of peri-implantitis with bone graft and collagen membrane, the choice of debridement/decontamination method (Er:YAG laser vs curets+saline) did not significantly affect 6-month clinical or radiographic outcomes.
Addition of deproteinized bovine bone mineral plus a collagen membrane produced greater radiographic bone fill of intrabony periodontal defects at 1 year versus flap surgery alone.
Randomized controlled trial of transurethral radiofrequency collagen micro-remodeling vs sham for female stress urinary incontinence showing improved quality-of-life scores and increased leak point pressure at 12 months.
Randomized controlled trial of transurethral radiofrequency collagen micro-remodeling vs sham for female stress urinary incontinence showing improved quality-of-life scores and increased leak point pressure at 12 months.
Prospective clinical trial using anorganic bovine bone covered with a resorbable collagen membrane versus no graft/membrane in large periapical lesions; no significant benefit of the collagen membrane approach was found at one year.
Prospective clinical trial using anorganic bovine bone covered with a resorbable collagen membrane versus no graft/membrane in large periapical lesions; no significant benefit of the collagen membrane approach was found at one year.
Prospective case series testing a thermosensitive atelocollagen punctal plug with/without preheating; preheating (41°C) improved solidification and produced greater improvements in signs and symptoms of dry eye at 1 month.
Prospective case series testing a thermosensitive atelocollagen punctal plug with/without preheating; preheating (41°C) improved solidification and produced greater improvements in signs and symptoms of dry eye at 1 month.
Prospective case series testing a thermosensitive atelocollagen punctal plug with/without preheating; preheating (41°C) improved solidification and produced greater improvements in signs and symptoms of dry eye at 1 month.
Prospective case series testing a thermosensitive atelocollagen punctal plug with/without preheating; preheating (41°C) improved solidification and produced greater improvements in signs and symptoms of dry eye at 1 month.
Prospective randomized (non-blinded) trial comparing autogenous demineralized dentin matrix with bio-collagen membrane versus natural healing after lower third molar extraction; test group showed better probing depth and radiographic bone density but slightly greater early swelling.
A 24-week randomized phase 2 trial (n=72) found selonsertib-treated patients had higher rates of fibrosis improvement and reductions in hepatic collagen content versus simtuzumab alone.
Single-center randomized controlled trial in patients with thin peri-implant mucosa showed that placement of an allogenic collagen scaffold at implant placement produced modest but statistically significant soft-tissue thickening versus no grafting; marginal bone loss differences were small and not significant.
Single-center randomized controlled trial in patients with thin peri-implant mucosa showed that placement of an allogenic collagen scaffold at implant placement produced modest but statistically significant soft-tissue thickening versus no grafting; marginal bone loss differences were small and not significant.
Single-center randomized controlled trial in patients with thin peri-implant mucosa showed that placement of an allogenic collagen scaffold at implant placement produced modest but statistically significant soft-tissue thickening versus no grafting; marginal bone loss differences were small and not significant.
A randomized study testing absorbable membranes (including bovine collagen membrane) during bone grafting found membranes increased bone thickness gain.
A randomized study testing absorbable membranes (including bovine collagen membrane) during bone grafting found membranes increased bone thickness gain.
IV zoledronic acid after ACDF shortened time to osteogenesis, promoted fusion, lowered a collagen degradation marker (CTX) and increased lumbar spine BMD, with improved neck disability scores.
Hypertensive patients with LVH were randomized to losartan or atenolol to compare effects on myocardial collagen assessed by ultrasound echoreflectivity and serum collagen markers.
Hypertensive patients with LVH were randomized to losartan or atenolol to compare effects on myocardial collagen assessed by ultrasound echoreflectivity and serum collagen markers.
Postmenopausal women received varying doses of ibandronate; higher doses increased BMD and reduced biochemical markers of bone turnover including type I collagen breakdown products.
Oral low-molecular-weight collagen peptide (1 g/day) for 12 weeks improved skin hydration, reduced wrinkles, and increased elasticity in middle-aged women.
Oral low-molecular-weight collagen peptide (1 g/day) for 12 weeks improved skin hydration, reduced wrinkles, and increased elasticity in middle-aged women.
Patients undergoing VRAM flap reconstruction were randomized to collagen mesh-assisted closure or conventional closure; no significant reduction in incisional hernia at 1 year was found.
Multicentre RCT: adding a non‑crosslinked porcine collagen biological mesh at stoma closure reduced clinically detectable hernias at 2 years.
Multicentre RCT: adding a non‑crosslinked porcine collagen biological mesh at stoma closure reduced clinically detectable hernias at 2 years.
Multicentre RCT: adding a non‑crosslinked porcine collagen biological mesh at stoma closure reduced clinically detectable hernias at 2 years.
Single‑center randomized trial: placing a gentamicin‑collagen implant in the pelvis at surgery was associated with a lower 5‑year cumulative incidence of distant metastases versus control.
Single‑center randomized trial: placing a gentamicin‑collagen implant in the pelvis at surgery was associated with a lower 5‑year cumulative incidence of distant metastases versus control.
Randomized trial (15 per arm): rhBMP‑2 on an absorbable collagen sponge plus allograft showed similar healing rates to autograft with less blood loss and comparable functional improvement.
Randomized trial (15 per arm): rhBMP‑2 on an absorbable collagen sponge plus allograft showed similar healing rates to autograft with less blood loss and comparable functional improvement.
Randomized trial (15 per arm): rhBMP‑2 on an absorbable collagen sponge plus allograft showed similar healing rates to autograft with less blood loss and comparable functional improvement.
Intermittent senolytic therapy did not reduce overall bone resorption but transiently increased a bone formation marker and showed benefit in a high-senescent-burden subgroup.
Preoperative local vaginal estrogen increased vaginal wall thickness and markedly increased collagen I expression while decreasing collagen-degrading enzyme activity.
Preoperative local vaginal estrogen increased vaginal wall thickness and markedly increased collagen I expression while decreasing collagen-degrading enzyme activity.
Preoperative local vaginal estrogen increased vaginal wall thickness and markedly increased collagen I expression while decreasing collagen-degrading enzyme activity.
Intra-articular polymerized type I collagen injections improved pain and function in knee osteoarthritis versus placebo and were well tolerated.
Intra-articular polymerized type I collagen injections improved pain and function in knee osteoarthritis versus placebo and were well tolerated.
Intra-articular polymerized type I collagen injections improved pain and function in knee osteoarthritis versus placebo and were well tolerated.
Greater early decreases in serum CTx were associated with larger lumbar spine BMD increases at 12 months in postmenopausal women on monthly ibandronate.
Greater early decreases in serum CTx were associated with larger lumbar spine BMD increases at 12 months in postmenopausal women on monthly ibandronate.
Adding dehydrated amniotic membrane allograft to standard care increased the proportion of chronic diabetic foot ulcers completely closed by 6 weeks versus standard care alone.
Twelve weeks of maximal squat strength training increased lumbar spine and hip BMD and raised a bone formation marker and strength outcomes in young women.
Twelve weeks of maximal squat strength training increased lumbar spine and hip BMD and raised a bone formation marker and strength outcomes in young women.
Collagenated porcine bone graft reduced ridge volume loss and basal surface shrinkage compared with cortical porcine bone after 3 months.
Collagenated porcine bone graft reduced ridge volume loss and basal surface shrinkage compared with cortical porcine bone after 3 months.
Collagenated porcine bone graft reduced ridge volume loss and basal surface shrinkage compared with cortical porcine bone after 3 months.
Adding deproteinized bovine bone mineral and a collagen membrane around block grafts reduced graft resorption but increased complication frequency.
Adding deproteinized bovine bone mineral and a collagen membrane around block grafts reduced graft resorption but increased complication frequency.
Adding deproteinized bovine bone mineral and a collagen membrane around block grafts reduced graft resorption but increased complication frequency.
Primary flap closure tended to reduce soft tissue shrinkage after alveolar ridge preservation, but differences were not statistically significant.
Primary flap closure tended to reduce soft tissue shrinkage after alveolar ridge preservation, but differences were not statistically significant.
Primary flap closure tended to reduce soft tissue shrinkage after alveolar ridge preservation, but differences were not statistically significant.
Histological study comparing collagen I/III ratios in skin and aponeurosis found much lower I/III ratios in patients with ventral hernias versus controls.
Histological study comparing collagen I/III ratios in skin and aponeurosis found much lower I/III ratios in patients with ventral hernias versus controls.
Histological study comparing collagen I/III ratios in skin and aponeurosis found much lower I/III ratios in patients with ventral hernias versus controls.
Randomized trial showed a collagen-based composite plus autologous plasma produced faster and more complete hemostasis at sternal and iliac crest bone sites than standard methods.
Randomized trial showed a collagen-based composite plus autologous plasma produced faster and more complete hemostasis at sternal and iliac crest bone sites than standard methods.
Randomized trial showed a collagen-based composite plus autologous plasma produced faster and more complete hemostasis at sternal and iliac crest bone sites than standard methods.
Randomized trial in chronic diabetic foot ulcers: a porcine-derived purified reconstituted bilayer matrix (ECM product) produced higher 12-week healing rates, faster healing, and much greater wound area reduction than standard collagen-alginate dressing.
Randomized double-blind trial testing etanercept vs placebo after heart transplant; measured LV mass and myocardial collagen deposition.
Randomized double-blind trial testing etanercept vs placebo after heart transplant; measured LV mass and myocardial collagen deposition.
In ART‑naive HIV patients who completed follow‑up, starting antiretroviral therapy (especially PI‑containing regimens) was associated with early fat mass gain and an early drop in lumbar spine BMD; vitamin D was measured but not an intervention.
In ART‑naive HIV patients who completed follow‑up, starting antiretroviral therapy (especially PI‑containing regimens) was associated with early fat mass gain and an early drop in lumbar spine BMD; vitamin D was measured but not an intervention.
Randomized nonblinded multicenter pilot comparing rhBMP-2 on an absorbable collagen sponge versus autograft for single-level posterior lumbar interbody fusion.
Using rhBMP-2 on an absorbable collagen sponge with interbody cages yielded higher fusion rates and less operative time and blood loss than autograft, avoiding donor-site morbidity.
Randomized nonblinded multicenter pilot comparing rhBMP-2 on an absorbable collagen sponge versus autograft for single-level posterior lumbar interbody fusion.
Multicenter double-blind randomized trial (stage III knee OA subgroup) showing undenatured type II chicken collagen (NK2/Artneo) improved pain, stiffness, function and quality of life vs placebo over 180 days.
Multicenter double-blind randomized trial (stage III knee OA subgroup) showing undenatured type II chicken collagen (NK2/Artneo) improved pain, stiffness, function and quality of life vs placebo over 180 days.
Split-mouth randomized trial comparing rhPDGF-BB + beta-TCP + bioabsorbable collagen dressing versus connective tissue graft for gingival recession; both improved clinically, with some measures favoring CTG and others favoring the test.
In early RA, higher baseline RANKL:OPG ratio and collagen degradation markers predicted faster radiological joint damage over 11 years.
After corneal collagen crosslinking, oral ketorolac and gabapentin provided similar pain control and similar adverse event profiles.
After corneal collagen crosslinking, oral ketorolac and gabapentin provided similar pain control and similar adverse event profiles.
Compared immediate implant placement versus delayed placement with socket preservation using bovine bone and a resorbable collagen barrier; immediate placement had more complications but similar aesthetics and patient satisfaction.
PCA increased type I collagen synthesis in vitro and, in a 8-week lotion trial in women, significantly reduced facial wrinkle measures.
In 81 hepatitis B patients randomized to Kangxian Baogan Decoction or standard care, the decoction group showed reductions in serum fibrosis markers and improved liver pathology.
Adding Clostridium butyricum to rosuvastatin in NAFLD patients improved gut microbiota composition and reduced lipids, liver enzymes, fibrosis markers and inflammatory cytokines compared with rosuvastatin alone.
Simvastatin reduced plaque inflammation and MMP activity and increased plaque collagen content, consistent with plaque stabilization.
In cardiac surgery patients, adding collagen–gentamicin sponges to standard prophylaxis halved sternal wound infection rates (4.3% vs 9.0%) but increased early reoperation for bleeding.
In cardiac surgery patients, adding collagen–gentamicin sponges to standard prophylaxis halved sternal wound infection rates (4.3% vs 9.0%) but increased early reoperation for bleeding.
Two randomized treatment groups of postmenopausal women showed that certain bisphosphonate doses halved a urine cartilage collagen degradation marker (CTX-II) and markedly lowered a bone collagen marker (CTX-I).
Two randomized treatment groups of postmenopausal women showed that certain bisphosphonate doses halved a urine cartilage collagen degradation marker (CTX-II) and markedly lowered a bone collagen marker (CTX-I).
Teriparatide substantially reduced fracture incidence versus placebo across subgroups defined by bone turnover markers.
In patients with type 2 diabetes, eplerenone reduced adipose tissue fibrosis and lowered collagen I/VI production compared with placebo.
In patients with type 2 diabetes, eplerenone reduced adipose tissue fibrosis and lowered collagen I/VI production compared with placebo.
In patients with severe carotid stenosis, Qingre Quyu Granule plus standard care increased plaque collagen and reduced inflammatory and matrix-degrading markers versus control.
In patients with severe carotid stenosis, Qingre Quyu Granule plus standard care increased plaque collagen and reduced inflammatory and matrix-degrading markers versus control.
In patients with severe carotid stenosis, Qingre Quyu Granule plus standard care increased plaque collagen and reduced inflammatory and matrix-degrading markers versus control.
In knee OA patients, IA-HA increased urinary CTX-II while NSAID decreased it; both improved symptoms.
In type 2 diabetic patients, marine collagen peptides (MCPs) improved multiple metabolic/inflammatory biomarkers versus placebo over 3 months.
In type 2 diabetic patients, marine collagen peptides (MCPs) improved multiple metabolic/inflammatory biomarkers versus placebo over 3 months.
In type 2 diabetic patients, marine collagen peptides (MCPs) improved multiple metabolic/inflammatory biomarkers versus placebo over 3 months.
Using a bovine bone graft plus absorbable collagen membrane preserved alveolar ridge height, width, and volume better than no treatment.
Using a bovine bone graft plus absorbable collagen membrane preserved alveolar ridge height, width, and volume better than no treatment.
Using a bovine bone graft plus absorbable collagen membrane preserved alveolar ridge height, width, and volume better than no treatment.
In healthy men, single IV doses of Revacept dose-dependently inhibited collagen-induced platelet aggregation without affecting bleeding time or general hemostasis.
Phase 3 randomized trial: adding a gentamicin-collagen sponge at wound closure increased surgical-site infections compared with standard care.
Phase 3 randomized trial: adding a gentamicin-collagen sponge at wound closure increased surgical-site infections compared with standard care.
Phase 3 randomized trial: adding a gentamicin-collagen sponge at wound closure increased surgical-site infections compared with standard care.
Four-year randomized substudy comparing losartan vs atenolol: no long-term differences in circulating collagen markers or LV mass, though first-year PICP change predicted later LV mass regression with losartan.
Four-year randomized substudy comparing losartan vs atenolol: no long-term differences in circulating collagen markers or LV mass, though first-year PICP change predicted later LV mass regression with losartan.
Four-year randomized substudy comparing losartan vs atenolol: no long-term differences in circulating collagen markers or LV mass, though first-year PICP change predicted later LV mass regression with losartan.
Small clinical comparison: 3 months of pravastatin before carotid endarterectomy increased plaque collagen and TIMP-1 and decreased lipid, inflammation, MMP-2, and cell death.
Small clinical comparison: 3 months of pravastatin before carotid endarterectomy increased plaque collagen and TIMP-1 and decreased lipid, inflammation, MMP-2, and cell death.
Small clinical comparison: 3 months of pravastatin before carotid endarterectomy increased plaque collagen and TIMP-1 and decreased lipid, inflammation, MMP-2, and cell death.
Double-blind randomized study in postmenopausal women: sublingual hormone therapy reduced bone turnover including type I collagen N-telopeptide and increased spine and hip BMD over 12 months.
Bazedoxifene/conjugated estrogens increased spine and hip bone mineral density and reduced bone turnover markers versus placebo in postmenopausal women at risk for osteoporosis.
Double-blind randomized study in postmenopausal women: sublingual hormone therapy reduced bone turnover including type I collagen N-telopeptide and increased spine and hip BMD over 12 months.
Weekly injections of polymerized type I collagen reduced inflammatory signals and improved skin structure in patients with localized scleroderma.
Weekly injections of polymerized type I collagen reduced inflammatory signals and improved skin structure in patients with localized scleroderma.
Weekly injections of polymerized type I collagen reduced inflammatory signals and improved skin structure in patients with localized scleroderma.
Weekly injections of polymerized type I collagen reduced inflammatory signals and improved skin structure in patients with localized scleroderma.
Weekly injections of polymerized type I collagen reduced inflammatory signals and improved skin structure in patients with localized scleroderma.
Oral bovine type I collagen did not improve skin scores overall in diffuse cutaneous systemic sclerosis, but a late-phase subgroup showed greater skin score improvement at month 15.
Oral bovine type I collagen did not improve skin scores overall in diffuse cutaneous systemic sclerosis, but a late-phase subgroup showed greater skin score improvement at month 15.
A collagen-plug closure device (Angio-Seal) produced slightly higher immediate hemostasis and total success than a suture device, with similar complication rates.
A collagen-plug closure device (Angio-Seal) produced slightly higher immediate hemostasis and total success than a suture device, with similar complication rates.
A collagen-plug closure device (Angio-Seal) produced slightly higher immediate hemostasis and total success than a suture device, with similar complication rates.
Topical type I collagen powder showed a non-significant trend to less overall drainage; in patients with >10 nodes removed it significantly reduced lymphorrhea volume and duration.
Topical type I collagen powder showed a non-significant trend to less overall drainage; in patients with >10 nodes removed it significantly reduced lymphorrhea volume and duration.
Topical type I collagen powder showed a non-significant trend to less overall drainage; in patients with >10 nodes removed it significantly reduced lymphorrhea volume and duration.
Randomized trial comparing periosteum cover vs type I/III collagen membrane for knee chondral repair; 2-year follow-up.
Randomized trial comparing periosteum cover vs type I/III collagen membrane for knee chondral repair; 2-year follow-up.
Oral alendronate and yearly zoledronic acid similarly increased bone density and strongly reduced bone resorption biomarkers in adults with osteogenesis imperfecta.
Double-blind placebo-controlled trial: intramuscular porcine type I collagen-PVP vs placebo in active rheumatoid arthritis over 6 months.
Double-blind placebo-controlled trial: intramuscular porcine type I collagen-PVP vs placebo in active rheumatoid arthritis over 6 months.
Double-blind placebo-controlled trial: intramuscular porcine type I collagen-PVP vs placebo in active rheumatoid arthritis over 6 months.
Biomarker sub-study of an RCT in RA showing tocilizumab reduces collagen-degradation biomarkers and CRP more than methotrexate by week 8.
12-week randomized placebo-controlled trial: small-dose undenatured type II collagen improved knee flexibility, reduced joint discomfort, and improved motor function versus placebo.
12-week randomized placebo-controlled trial: small-dose undenatured type II collagen improved knee flexibility, reduced joint discomfort, and improved motor function versus placebo.
Placing acellular dermis during parotidectomy markedly reduced objective Frey's syndrome on starch-iodine testing but increased some postoperative complications.
Placing acellular dermis during parotidectomy markedly reduced objective Frey's syndrome on starch-iodine testing but increased some postoperative complications.
Placing acellular dermis during parotidectomy markedly reduced objective Frey's syndrome on starch-iodine testing but increased some postoperative complications.
24-week randomized, double-blind trial in athletes: collagen hydrolysate reduced several measures of activity-related joint pain versus placebo, with stronger effects in a knee-arthralgia subgroup.
24-week randomized, double-blind trial in athletes: collagen hydrolysate reduced several measures of activity-related joint pain versus placebo, with stronger effects in a knee-arthralgia subgroup.
24-week randomized, double-blind trial in athletes: collagen hydrolysate reduced several measures of activity-related joint pain versus placebo, with stronger effects in a knee-arthralgia subgroup.
Higher baseline endotrophin (a procollagen VI fragment) identified patients who showed better glycemic responses and fewer PPARγ-related adverse effects.
Higher baseline endotrophin (a procollagen VI fragment) identified patients who showed better glycemic responses and fewer PPARγ-related adverse effects.
Higher baseline endotrophin (a procollagen VI fragment) identified patients who showed better glycemic responses and fewer PPARγ-related adverse effects.
Infliximab induction increased markers of bone formation and resorption in children with Crohn's disease and these changes associated with improved growth and disease activity.
Infliximab induction increased markers of bone formation and resorption in children with Crohn's disease and these changes associated with improved growth and disease activity.
Residual defect height >1 mm after guided bone regeneration was associated with higher bleeding on probing and tended to increase mucosal recession at 4 years.
All cemented prosthesis designs led to early proximal femoral bone loss and transient increases in bone turnover markers; patterns were similar across designs.
All cemented prosthesis designs led to early proximal femoral bone loss and transient increases in bone turnover markers; patterns were similar across designs.
Addition of deproteinized bovine bone mineral plus a collagen membrane produced greater radiographic bone fill of intrabony periodontal defects at 1 year versus flap surgery alone.
Tocilizumab plus methotrexate rapidly reduced cartilage turnover and proteolytic markers and reduced bone resorption while increasing bone formation markers in RA patients.
Tocilizumab plus methotrexate rapidly reduced cartilage turnover and proteolytic markers and reduced bone resorption while increasing bone formation markers in RA patients.
Tocilizumab plus methotrexate rapidly reduced cartilage turnover and proteolytic markers and reduced bone resorption while increasing bone formation markers in RA patients.
In 30 patients (32 sockets) grafted with biphasic calcium phosphate, sites covered by a PEG synthetic membrane lost less labial and coronal bone percentage than sites covered by porcine collagen membrane at 22 weeks.
In 30 patients (32 sockets) grafted with biphasic calcium phosphate, sites covered by a PEG synthetic membrane lost less labial and coronal bone percentage than sites covered by porcine collagen membrane at 22 weeks.
RCT comparing porcine-derived bioabsorbable collagen membrane versus ePTFE for GBR around implants; both membranes reduced defect dimensions, with some differences by metric.
RCT comparing porcine-derived bioabsorbable collagen membrane versus ePTFE for GBR around implants; both membranes reduced defect dimensions, with some differences by metric.
RCT comparing porcine-derived bioabsorbable collagen membrane versus ePTFE for GBR around implants; both membranes reduced defect dimensions, with some differences by metric.
Absorbable plain gut (collagen-derived) sutures produced similar or slightly better long-term cosmetic outcomes than nylon sutures in children.
Using a collagen membrane with bone graft produced similar tooth-supporting tissue gain as the alternative treatment over 12 months.
Using a collagen membrane with bone graft produced similar tooth-supporting tissue gain as the alternative treatment over 12 months.
A collagen scaffold seeded with hUC-MSCs led to a non-significant higher live-birth rate and significantly increased endometrial thickness; two patients developed transient urticaria.
A collagen scaffold seeded with hUC-MSCs led to a non-significant higher live-birth rate and significantly increased endometrial thickness; two patients developed transient urticaria.
A collagen scaffold seeded with hUC-MSCs led to a non-significant higher live-birth rate and significantly increased endometrial thickness; two patients developed transient urticaria.
In 81 hepatitis B patients randomized to Kangxian Baogan Decoction or standard care, the decoction group showed reductions in serum fibrosis markers and improved liver pathology.
In 81 hepatitis B patients randomized to Kangxian Baogan Decoction or standard care, the decoction group showed reductions in serum fibrosis markers and improved liver pathology.
Two randomized double‑blind placebo‑controlled studies showed oral salmon calcitonin exposure varied between and within individuals; higher exposure correlated strongly with greater suppression of serum CTX‑I (bone resorption marker).
Two randomized double‑blind placebo‑controlled studies showed oral salmon calcitonin exposure varied between and within individuals; higher exposure correlated strongly with greater suppression of serum CTX‑I (bone resorption marker).
In two randomized placebo‑controlled studies in 81 postmenopausal women, bedtime GLP‑2 injections produced a dose‑related reduction in the bone resorption marker s‑CTX and a trend toward increased osteocalcin.
Placing a gentamycin-containing collagen sponge after rectal cancer surgery reduced early postoperative complications and improved 3-year survival.
Placing a gentamycin-containing collagen sponge after rectal cancer surgery reduced early postoperative complications and improved 3-year survival.
Placing a gentamycin-containing collagen sponge after rectal cancer surgery reduced early postoperative complications and improved 3-year survival.
Double-blind RCT comparing bovine bone + membrane vs pure β-tricalcium phosphate (a calcium phosphate) + membrane for horizontal augmentation: no major differences, with a small (0.24 mm) less peri-implant radiographic bone loss favoring the β-TCP group.
Randomized trial (78 enrolled, 8 excluded/dropouts = 70 completed) comparing internal socket grafting alone versus with additional buccal augmentation covered by collagen resorbable membranes; no significant differences at 6 months.
Double-blind RCT comparing bovine bone + membrane vs pure β-tricalcium phosphate (a calcium phosphate) + membrane for horizontal augmentation: no major differences, with a small (0.24 mm) less peri-implant radiographic bone loss favoring the β-TCP group.
Double-blind RCT comparing bovine bone + membrane vs pure β-tricalcium phosphate (a calcium phosphate) + membrane for horizontal augmentation: no major differences, with a small (0.24 mm) less peri-implant radiographic bone loss favoring the β-TCP group.
Double-blind RCT comparing bovine bone + membrane vs pure β-tricalcium phosphate (a calcium phosphate) + membrane for horizontal augmentation: no major differences, with a small (0.24 mm) less peri-implant radiographic bone loss favoring the β-TCP group.
When consumed for three days after downhill running, collagen hydrolysate did not improve muscle soreness, muscle function, or blood markers of muscle damage compared with dairy protein or placebo.
When consumed for three days after downhill running, collagen hydrolysate did not improve muscle soreness, muscle function, or blood markers of muscle damage compared with dairy protein or placebo.
When consumed for three days after downhill running, collagen hydrolysate did not improve muscle soreness, muscle function, or blood markers of muscle damage compared with dairy protein or placebo.
Multicenter randomized trial comparing rhOP-1 delivered in a type I collagen carrier versus autograft for tibial nonunions; clinical and radiographic healing were similar between groups.
Multicenter randomized trial comparing rhOP-1 delivered in a type I collagen carrier versus autograft for tibial nonunions; clinical and radiographic healing were similar between groups.
Multicenter randomized trial comparing rhOP-1 delivered in a type I collagen carrier versus autograft for tibial nonunions; clinical and radiographic healing were similar between groups.
In Chinese postmenopausal women, daily fortified milk (1200 mg calcium + vitamin D + FOS-inulin) for 52 weeks increased 25(OH)D, suppressed bone turnover markers and preserved femoral neck BMD compared with regular milk.
In Chinese postmenopausal women, daily fortified milk (1200 mg calcium + vitamin D + FOS-inulin) for 52 weeks increased 25(OH)D, suppressed bone turnover markers and preserved femoral neck BMD compared with regular milk.
In Chinese postmenopausal women, daily fortified milk (1200 mg calcium + vitamin D + FOS-inulin) for 52 weeks increased 25(OH)D, suppressed bone turnover markers and preserved femoral neck BMD compared with regular milk.
Analysis of two RCTs (including one of oral type I collagen) assessing sensitivity of MRSS body sites; total MRSS showed large effect sizes and some sites (hands, forearms, chest) were more sensitive to change.
Analysis of two RCTs (including one of oral type I collagen) assessing sensitivity of MRSS body sites; total MRSS showed large effect sizes and some sites (hands, forearms, chest) were more sensitive to change.
Analysis of two RCTs (including one of oral type I collagen) assessing sensitivity of MRSS body sites; total MRSS showed large effect sizes and some sites (hands, forearms, chest) were more sensitive to change.
Randomized study of immediate molar implants using autologous bone chips, a collagen membrane (Ossix), or both; after 12 months all groups had similar modest marginal bone loss.
Randomized study of immediate molar implants using autologous bone chips, a collagen membrane (Ossix), or both; after 12 months all groups had similar modest marginal bone loss.
A porcine collagen implant (Ologen) used during trabeculectomy lowered intraocular pressure similarly to mitomycin‑C over 5 years with comparable safety.
A porcine collagen implant (Ologen) used during trabeculectomy lowered intraocular pressure similarly to mitomycin‑C over 5 years with comparable safety.
Guided tissue regeneration with a collagen membrane plus Bio‑Oss produced clinical improvements similar to a PLA/PGA membrane at 1 year.
Guided tissue regeneration with a collagen membrane plus Bio‑Oss produced clinical improvements similar to a PLA/PGA membrane at 1 year.
Cross‑linked collagen membrane supported bone regeneration comparable to a native collagen membrane; premature membrane exposure was linked to soft‑tissue inflammation.
Cross‑linked collagen membrane supported bone regeneration comparable to a native collagen membrane; premature membrane exposure was linked to soft‑tissue inflammation.
Cross‑linked collagen membrane supported bone regeneration comparable to a native collagen membrane; premature membrane exposure was linked to soft‑tissue inflammation.
500 mg daily natural eggshell membrane (contains collagen I) vs placebo for 2 weeks reduced cartilage degradation and improved recovery from exercise-induced pain and stiffness in healthy postmenopausal women.
500 mg daily natural eggshell membrane (contains collagen I) vs placebo for 2 weeks reduced cartilage degradation and improved recovery from exercise-induced pain and stiffness in healthy postmenopausal women.
500 mg daily natural eggshell membrane (contains collagen I) vs placebo for 2 weeks reduced cartilage degradation and improved recovery from exercise-induced pain and stiffness in healthy postmenopausal women.
500 mg daily natural eggshell membrane (contains collagen I) vs placebo for 2 weeks reduced cartilage degradation and improved recovery from exercise-induced pain and stiffness in healthy postmenopausal women.
500 mg daily natural eggshell membrane (contains collagen I) vs placebo for 2 weeks reduced cartilage degradation and improved recovery from exercise-induced pain and stiffness in healthy postmenopausal women.
Randomized clinical assessment of guided-tissue regeneration using anorganic bovine bone plus a resorbable collagen membrane in periapical surgery; overall 1-year healing reported with possible benefit of GTR for transosseous (two-wall) lesions.
Randomized clinical assessment of guided-tissue regeneration using anorganic bovine bone plus a resorbable collagen membrane in periapical surgery; overall 1-year healing reported with possible benefit of GTR for transosseous (two-wall) lesions.
Randomized clinical assessment of guided-tissue regeneration using anorganic bovine bone plus a resorbable collagen membrane in periapical surgery; overall 1-year healing reported with possible benefit of GTR for transosseous (two-wall) lesions.
Collagen-coated mesh gave better objective anatomical repair than conventional repair at 1 and 3 years, but patient-reported symptoms were similar.
Collagen-coated mesh gave better objective anatomical repair than conventional repair at 1 and 3 years, but patient-reported symptoms were similar.
Using DBBM plus a porcine collagen membrane or matrix resulted in less new bone formation at 4 months than unassisted socket healing.
Alveolar ridge preservation using demineralized bovine bone with 10% collagen plus a collagen matrix reduced the need for additional bone grafting and attenuated ridge changes versus unassisted healing.
Alveolar ridge preservation using demineralized bovine bone with 10% collagen plus a collagen matrix reduced the need for additional bone grafting and attenuated ridge changes versus unassisted healing.
In third-trimester pregnant women, a bedtime 1200 mg calcium supplement reduced urinary markers of type I collagen breakdown (NTX) by about 14%.
In mandibular reconstruction, grafts with higher CD34+ cell concentrations (≥~200/mL) produced substantially better bone regeneration, higher radiographic density, and greater trabecular bone area; an absorbable collagen sponge was used as scaffold but CD34+ dose was the main variable.
In mandibular reconstruction, grafts with higher CD34+ cell concentrations (≥~200/mL) produced substantially better bone regeneration, higher radiographic density, and greater trabecular bone area; an absorbable collagen sponge was used as scaffold but CD34+ dose was the main variable.
In mandibular reconstruction, grafts with higher CD34+ cell concentrations (≥~200/mL) produced substantially better bone regeneration, higher radiographic density, and greater trabecular bone area; an absorbable collagen sponge was used as scaffold but CD34+ dose was the main variable.
A randomized multicentre trial (PP n=100) found the coll-HA osteochondral scaffold safe and—while overall similar to bone marrow stimulation—superior in predefined subgroups of complex osteochondral lesions.
A randomized multicentre trial (PP n=100) found the coll-HA osteochondral scaffold safe and—while overall similar to bone marrow stimulation—superior in predefined subgroups of complex osteochondral lesions.
A randomized multicentre trial (PP n=100) found the coll-HA osteochondral scaffold safe and—while overall similar to bone marrow stimulation—superior in predefined subgroups of complex osteochondral lesions.
Using a resorbable collagen membrane did not reduce horizontal bone resorption; piezosurgery showed no clinical advantage over rotative instruments and took longer.
Applying gentamicin-impregnated collagen fleeces after surgery reduced pathogen presence and postoperative perineal/sacral infections.
Applying gentamicin-impregnated collagen fleeces after surgery reduced pathogen presence and postoperative perineal/sacral infections.
Applying gentamicin-impregnated collagen fleeces after surgery reduced pathogen presence and postoperative perineal/sacral infections.
Adding a resorbable collagen membrane to bovine bone graft in extraction sockets increased the fraction of new bone compared with graft alone.
Adding a resorbable collagen membrane to bovine bone graft in extraction sockets increased the fraction of new bone compared with graft alone.
Adding a resorbable collagen membrane to bovine bone graft in extraction sockets increased the fraction of new bone compared with graft alone.
Compared immediate implant placement versus delayed placement with socket preservation using bovine bone and a resorbable collagen barrier; immediate placement had more complications but similar aesthetics and patient satisfaction.
Randomized multicenter trial comparing immediate post-extractive implants vs delayed implants (delayed group received socket preservation with bovine bone and a resorbable collagen barrier); aesthetics similar, more complications with immediate implants.
Compared immediate implant placement versus delayed placement with socket preservation using bovine bone and a resorbable collagen barrier; immediate placement had more complications but similar aesthetics and patient satisfaction.
Compared collagen-coated polyester patch closure versus direct closure in carotid surgery and found no significant differences in vessel occlusion, morbidity, or mortality at 12 months.
Compared collagen-coated polyester patch closure versus direct closure in carotid surgery and found no significant differences in vessel occlusion, morbidity, or mortality at 12 months.
Compared collagen-coated polyester patch closure versus direct closure in carotid surgery and found no significant differences in vessel occlusion, morbidity, or mortality at 12 months.
12-month RCT (51 subjects) showed guided tissue regeneration with collagen membrane improved probing depth and clinical attachment versus open flap debridement, but collagen membrane increased gingival recession compared with other treatments.
Postoperative oral prednisolone lowered serum markers of collagen synthesis systemically but did not improve surgical success of Molteno implantation over 6 months.
Undenatured chicken type II collagen (Artneo) taken daily for 180 days reduced pain and stiffness and improved joint function and quality of life versus placebo in knee OA.
Undenatured chicken type II collagen (Artneo) taken daily for 180 days reduced pain and stiffness and improved joint function and quality of life versus placebo in knee OA.
Undenatured chicken type II collagen (Artneo) taken daily for 180 days reduced pain and stiffness and improved joint function and quality of life versus placebo in knee OA.
PRP, PRP plus collagen sponge, and collagen membrane yielded similar high healing rates for apicomarginal defects over 1 year.
PRP, PRP plus collagen sponge, and collagen membrane yielded similar high healing rates for apicomarginal defects over 1 year.
Randomized allocation of 30 defects in 25 patients to graft alone, graft+PRP, and graft+PRP+membrane; all treatments improved clinical measures similarly with no added clinical benefit from PRP.
In women undergoing abdominoplasty, PRP and nanofat injections increased type I collagen in stretch-mark tissue; combined PRP+nanofat produced the largest increase and better clinical improvement.
In women undergoing abdominoplasty, PRP and nanofat injections increased type I collagen in stretch-mark tissue; combined PRP+nanofat produced the largest increase and better clinical improvement.
PCA increased type I collagen synthesis in vitro and, in a 8-week lotion trial in women, significantly reduced facial wrinkle measures.
PCA increased type I collagen synthesis in vitro and, in a 8-week lotion trial in women, significantly reduced facial wrinkle measures.
In periodontal defects, GTR using collagen membranes and autogenous periosteal+bone chip treatment both improved probing depth, attachment level, and bone defect fill more than debridement alone; autogenous periosteal approach gave greatest bone gain.
Randomized trial (78 enrolled, 8 excluded/dropouts = 70 completed) comparing internal socket grafting alone versus with additional buccal augmentation covered by collagen resorbable membranes; no significant differences at 6 months.
Randomized trial in ischemic foot wounds showed a collagen-based tissue-engineered skin graft substantially improved and accelerated wound healing versus moist dressings.
22 patients received vertical bone augmentation with either resorbable collagen barriers or nonresorbable barriers; both showed minimal and similar bone loss at 3 years.
22 patients received vertical bone augmentation with either resorbable collagen barriers or nonresorbable barriers; both showed minimal and similar bone loss at 3 years.
Multicenter randomized trial comparing a living skin-equivalent (Graftskin, a collagen-containing product) versus moist gauze for chronic diabetic foot ulcers; assessed healing at 12 weeks.
Multicenter randomized trial comparing a living skin-equivalent (Graftskin, a collagen-containing product) versus moist gauze for chronic diabetic foot ulcers; assessed healing at 12 weeks.
In people with relapsing-remitting MS, weekly high-dose vitamin D raised vitamin D levels but did not meaningfully change common blood markers of bone formation or resorption over 96 weeks.
Adding a 3D collagen graft to rotator cuff repair reduced tendon retears and improved shoulder scores at 12 months; final-function differences were not significant at longest follow-up.
Adding a 3D collagen graft to rotator cuff repair reduced tendon retears and improved shoulder scores at 12 months; final-function differences were not significant at longest follow-up.
Adding a 3D collagen graft to rotator cuff repair reduced tendon retears and improved shoulder scores at 12 months; final-function differences were not significant at longest follow-up.
In postmenopausal volunteers with low vitamin D, oral calcium produced marked suppression of bone resorption marker CTX (greater than vitamin D alone); vitamin D alone raised serum 25OHD but had smaller CTX effects.
In postmenopausal volunteers with low vitamin D, oral calcium produced marked suppression of bone resorption marker CTX (greater than vitamin D alone); vitamin D alone raised serum 25OHD but had smaller CTX effects.
In adults with knee pain, a multi‑component supplement containing glucosamine, chondroitin, quercetin, imidazole peptides and 200 IU vitamin D increased serum 25‑OHD and improved some measures of locomotor function versus placebo over 16 weeks.
Pregnant women in an individualized high-dairy-protein diet plus walking program had higher dietary calcium and protein intakes which was associated with reduced bone resorption and preserved bone formation during pregnancy and postpartum.
Pregnant women in an individualized high-dairy-protein diet plus walking program had higher dietary calcium and protein intakes which was associated with reduced bone resorption and preserved bone formation during pregnancy and postpartum.
Four-month randomized double-blind trial in prepubertal children found daily hydrolyzed collagen (with or without added calcium) increased markers related to bone modeling—most notably IGF-1 and alkaline phosphatase when collagen was given with calcium.
Pregnant women in an individualized high-dairy-protein diet plus walking program had higher dietary calcium and protein intakes which was associated with reduced bone resorption and preserved bone formation during pregnancy and postpartum.
In guided bone regeneration, early membrane exposure occurred in 10 of 29 sites; incision location and palatal/lingual gingival thickness influenced flap survival and membrane exposure, with collagen membranes among the tested materials.
In guided bone regeneration, early membrane exposure occurred in 10 of 29 sites; incision location and palatal/lingual gingival thickness influenced flap survival and membrane exposure, with collagen membranes among the tested materials.
In guided bone regeneration, early membrane exposure occurred in 10 of 29 sites; incision location and palatal/lingual gingival thickness influenced flap survival and membrane exposure, with collagen membranes among the tested materials.
In a biomarker subgroup of a randomized trial, higher baseline CTX-I (a type I collagen breakdown marker) predicted greater likelihood of clinical remission/response to abatacept+MTX, and abatacept+MTX produced greater reductions in several ECM/collagen-related biomarkers versus placebo+MTX.
In a biomarker subgroup of a randomized trial, higher baseline CTX-I (a type I collagen breakdown marker) predicted greater likelihood of clinical remission/response to abatacept+MTX, and abatacept+MTX produced greater reductions in several ECM/collagen-related biomarkers versus placebo+MTX.
In a biomarker subgroup of a randomized trial, higher baseline CTX-I (a type I collagen breakdown marker) predicted greater likelihood of clinical remission/response to abatacept+MTX, and abatacept+MTX produced greater reductions in several ECM/collagen-related biomarkers versus placebo+MTX.
A collagen shield presoaked with ofloxacin produced higher anterior chamber antibiotic concentrations than topical drops before cataract surgery.
A collagen shield presoaked with ofloxacin produced higher anterior chamber antibiotic concentrations than topical drops before cataract surgery.
In ~82 women >40, 24 weeks of the herbal mixture improved facial wrinkles and increased type I procollagen expression in skin compared with placebo.
In ~82 women >40, 24 weeks of the herbal mixture improved facial wrinkles and increased type I procollagen expression in skin compared with placebo.
In ~82 women >40, 24 weeks of the herbal mixture improved facial wrinkles and increased type I procollagen expression in skin compared with placebo.
Denosumab increased bone mineral density more than risedronate over 24 months; all participants received daily calcium and vitamin D as background therapy.
Denosumab increased bone mineral density more than risedronate over 24 months; all participants received daily calcium and vitamin D as background therapy.
Denosumab increased bone mineral density more than risedronate over 24 months; all participants received daily calcium and vitamin D as background therapy.
In 54 patients with decompensated cirrhosis, 28 days of rifaximin‑α produced no significant changes in macrophage activation markers or neoepitope collagen remodeling markers compared with placebo.
In 54 patients with decompensated cirrhosis, 28 days of rifaximin‑α produced no significant changes in macrophage activation markers or neoepitope collagen remodeling markers compared with placebo.
In 54 patients with decompensated cirrhosis, 28 days of rifaximin‑α produced no significant changes in macrophage activation markers or neoepitope collagen remodeling markers compared with placebo.
In 45 patients with bilateral impacted lower third molars, use of bovine porous bone mineral with or without a collagen membrane reduced pocket depth and gained attachment versus untreated controls over long follow‑up.
Randomized trial of neridronate vs control in thalassaemia-associated osteoporosis; both groups received calcium + 400 IU vitamin D daily; neridronate increased BMD and reduced bone turnover and back pain.
Randomized clinical comparison found the new collagen barrier membrane produced similar histologic bone regeneration to standard e-PTFE membrane.
Randomized clinical comparison found the new collagen barrier membrane produced similar histologic bone regeneration to standard e-PTFE membrane.
Randomized clinical comparison found the new collagen barrier membrane produced similar histologic bone regeneration to standard e-PTFE membrane.
In post-MI patients with LV dysfunction, collagen turnover biomarkers predicted outcomes and eplerenone reduced procollagen levels over follow-up.
In post-MI patients with LV dysfunction, collagen turnover biomarkers predicted outcomes and eplerenone reduced procollagen levels over follow-up.
Four-month randomized double-blind trial in prepubertal children found daily hydrolyzed collagen (with or without added calcium) increased markers related to bone modeling—most notably IGF-1 and alkaline phosphatase when collagen was given with calcium.
Four-month randomized double-blind trial in prepubertal children found daily hydrolyzed collagen (with or without added calcium) increased markers related to bone modeling—most notably IGF-1 and alkaline phosphatase when collagen was given with calcium.
Four-month randomized double-blind trial in prepubertal children found daily hydrolyzed collagen (with or without added calcium) increased markers related to bone modeling—most notably IGF-1 and alkaline phosphatase when collagen was given with calcium.
Compared two acellular dermal matrix products in bilateral breast reconstruction; AlloDerm had more seromas and slightly lower incorporation than DermACELL.
Compared two acellular dermal matrix products in bilateral breast reconstruction; AlloDerm had more seromas and slightly lower incorporation than DermACELL.
Compared two acellular dermal matrix products in bilateral breast reconstruction; AlloDerm had more seromas and slightly lower incorporation than DermACELL.
Ridge preservation using corticocancellous porcine bone plus a collagen membrane significantly limited horizontal and vertical ridge resorption and increased mineralized bone versus extraction alone after 7 months.
Ridge preservation using corticocancellous porcine bone plus a collagen membrane significantly limited horizontal and vertical ridge resorption and increased mineralized bone versus extraction alone after 7 months.
Ridge preservation using corticocancellous porcine bone plus a collagen membrane significantly limited horizontal and vertical ridge resorption and increased mineralized bone versus extraction alone after 7 months.
In combined surgical therapy of peri-implantitis with bone graft and collagen membrane, the choice of debridement/decontamination method (Er:YAG laser vs curets+saline) did not significantly affect 6-month clinical or radiographic outcomes.
Among abstinent smokers who completed the protocol (n=39), 10 days of transdermal nicotine increased type I procollagen levels compared with placebo.
Among abstinent smokers who completed the protocol (n=39), 10 days of transdermal nicotine increased type I procollagen levels compared with placebo.
In 833 glucocorticoid-treated patients, annual zoledronic acid reduced bone turnover markers more than daily risedronate over 12 months.
Multicenter randomized trial found rhBMP-2 on an absorbable collagen sponge produced substantial new bone and comparable implant outcomes to autograft, with less donor-site morbidity.
Multicenter randomized trial found rhBMP-2 on an absorbable collagen sponge produced substantial new bone and comparable implant outcomes to autograft, with less donor-site morbidity.
Multicenter randomized trial found rhBMP-2 on an absorbable collagen sponge produced substantial new bone and comparable implant outcomes to autograft, with less donor-site morbidity.
In advanced NSCLC, higher tumor COL4A3 mRNA expression was associated with shorter overall survival after cisplatin–gemcitabine chemotherapy.
In advanced NSCLC, higher tumor COL4A3 mRNA expression was associated with shorter overall survival after cisplatin–gemcitabine chemotherapy.
In advanced NSCLC, higher tumor COL4A3 mRNA expression was associated with shorter overall survival after cisplatin–gemcitabine chemotherapy.
Randomized study comparing a synthetic PEG hydrogel membrane vs standard collagen membrane for guided bone regeneration around implants; regenerated bone was similar and both membranes performed comparably after 6 months.
Randomized study comparing a synthetic PEG hydrogel membrane vs standard collagen membrane for guided bone regeneration around implants; regenerated bone was similar and both membranes performed comparably after 6 months.
Randomized controlled trial of socket preservation using bovine bone mineral plus porcine collagen membrane vs extraction alone; collagen membrane with graft markedly limited horizontal and vertical ridge resorption at 4 months.
Randomized controlled trial of socket preservation using bovine bone mineral plus porcine collagen membrane vs extraction alone; collagen membrane with graft markedly limited horizontal and vertical ridge resorption at 4 months.
Randomized controlled trial of socket preservation using bovine bone mineral plus porcine collagen membrane vs extraction alone; collagen membrane with graft markedly limited horizontal and vertical ridge resorption at 4 months.
Prospective randomized study comparing preoperative tobramycin-dexamethasone drops vs a pre-soaked collagen shield in cataract patients; aqueous antibiotic concentrations were similar and both below MIC, with no adverse effects from the collagen shield.
Prospective randomized study comparing preoperative tobramycin-dexamethasone drops vs a pre-soaked collagen shield in cataract patients; aqueous antibiotic concentrations were similar and both below MIC, with no adverse effects from the collagen shield.
Proof-of-principle randomized study of collagen scaffolds with/without autologous BM-MSCs for periodontal defects: all treatments led to significant clinical improvements over 12 months with no adverse healing events; radiographic bone fill was less in scaffold-only group.
In adults with knee pain, a multi‑component supplement containing glucosamine, chondroitin, quercetin, imidazole peptides and 200 IU vitamin D increased serum 25‑OHD and improved some measures of locomotor function versus placebo over 16 weeks.
In adults with knee pain, a multi‑component supplement containing glucosamine, chondroitin, quercetin, imidazole peptides and 200 IU vitamin D increased serum 25‑OHD and improved some measures of locomotor function versus placebo over 16 weeks.
Eight weeks of split-face home device use improved skin-aging measures and increased type I collagen expression while decreasing MMP-1, with no adverse effects.
Measured urine type II collagen neoepitope and related it to radiographic knee joint narrowing over 30 months in 120 women with unilateral knee OA.
Measured urine type II collagen neoepitope and related it to radiographic knee joint narrowing over 30 months in 120 women with unilateral knee OA.
Higher plasma LBP and sTLR4 were associated with worse knee OA progression and increased urinary collagen-breakdown marker over 16–18 months.
In patients starting glucocorticoids, alfacalcidol (a vitamin D analog) increased some bone formation markers but BMD fell with alfacalcidol while it increased with alendronate over 18 months.
In patients starting glucocorticoids, alfacalcidol (a vitamin D analog) increased some bone formation markers but BMD fell with alfacalcidol while it increased with alendronate over 18 months.
Subgroup analysis from a large randomized trial showing strontium ranelate lowered urinary CTX‑II (cartilage collagen II degradation marker) over 3 years in postmenopausal women.
Double‑blind RCT of hydrolyzed chicken type II collagen (2.5 g/day) versus placebo in adults with joint discomfort over 8 weeks; assessed pain, stiffness, and function.
Double‑blind RCT of hydrolyzed chicken type II collagen (2.5 g/day) versus placebo in adults with joint discomfort over 8 weeks; assessed pain, stiffness, and function.
Randomized study in paraquat poisoning patients testing Xuebijing plus conventional therapy versus conventional therapy; measured TGF‑β1, procollagen III peptide, and mortality.
Randomized study in paraquat poisoning patients testing Xuebijing plus conventional therapy versus conventional therapy; measured TGF‑β1, procollagen III peptide, and mortality.
Randomized study in paraquat poisoning patients testing Xuebijing plus conventional therapy versus conventional therapy; measured TGF‑β1, procollagen III peptide, and mortality.
Randomized trial in patients with bone defects: porous hydroxyapatite/collagen implant produced superior radiographic bone regeneration versus porous β-TCP by 18–24 weeks, with more (non-serious) adverse events.
Randomized trial in patients with bone defects: porous hydroxyapatite/collagen implant produced superior radiographic bone regeneration versus porous β-TCP by 18–24 weeks, with more (non-serious) adverse events.
12-week randomized double-blind pilot of a multinutrient supplement containing collagen (type II and collagen complex) showed within-group improvements in KOOS subscores and QoL, but did not significantly outperform placebo on the primary endpoint.
12-week randomized double-blind pilot of a multinutrient supplement containing collagen (type II and collagen complex) showed within-group improvements in KOOS subscores and QoL, but did not significantly outperform placebo on the primary endpoint.
12-week randomized double-blind pilot of a multinutrient supplement containing collagen (type II and collagen complex) showed within-group improvements in KOOS subscores and QoL, but did not significantly outperform placebo on the primary endpoint.
Multicenter randomized comparison of yearly zoledronic acid vs weekly alendronate in ~600 postmenopausal women assessing bone turnover markers (NTx, P1NP): zoledronic acid produced a greater and faster reduction in both markers.
Multicenter randomized comparison of yearly zoledronic acid vs weekly alendronate in ~600 postmenopausal women assessing bone turnover markers (NTx, P1NP): zoledronic acid produced a greater and faster reduction in both markers.
Short randomized trial showing rosiglitazone reduces biochemical markers of bone formation (including a procollagen marker) and decreases hip BMD in postmenopausal women.
PTH therapy increased early collagen-formation markers and larger short-term increases predicted greater spine and hip BMD gains at 1 year.
In 24 patients, rhBMP-2 delivered on an absorbable collagen sponge (ACS) produced greater immediate subcrestal radiographic horizontal bone gain than autogenous graft; clinical gains at 6 months were similar.
In 24 patients, rhBMP-2 delivered on an absorbable collagen sponge (ACS) produced greater immediate subcrestal radiographic horizontal bone gain than autogenous graft; clinical gains at 6 months were similar.
Inflammatory hand OA patients showed biomarker variation; prednisolone did not change most collagen-related biomarkers over 6 weeks.
Compared two xenograft ridge-preservation protocols in humans; the protocol using a cross-linked bovine collagen sponge produced more vital bone than the other, while clinical dimensional changes were similar.
rhBMP-2 on an absorbable collagen sponge regenerated more buccal bone and preserved ridge dimensions better than collagen sponge alone after flapless extraction.
rhBMP-2 on an absorbable collagen sponge regenerated more buccal bone and preserved ridge dimensions better than collagen sponge alone after flapless extraction.
rhBMP-2 on an absorbable collagen sponge regenerated more buccal bone and preserved ridge dimensions better than collagen sponge alone after flapless extraction.
Immediate implants with or without anorganic bovine bone + resorbable collagen barrier were compared over 3 years; no difference in implant failures but graft+collagen group showed greater marginal bone loss and worse esthetic/patient satisfaction.
Randomized multicenter trial comparing immediate post-extractive implants vs delayed implants (delayed group received socket preservation with bovine bone and a resorbable collagen barrier); aesthetics similar, more complications with immediate implants.
Measured circulating collagen neo-peptides in patients with metastatic pancreatic cancer and found that a high C3M/PRO-C3 ratio predicted better response (PFS, OS, ORR) to pegvorhyaluronidase alfa plus chemotherapy.
Combination DMARD therapy suppressed a serum marker of type I collagen degradation (ICTP) early and was linked to less radiographic joint damage over 2 years.
Combination DMARD therapy suppressed a serum marker of type I collagen degradation (ICTP) early and was linked to less radiographic joint damage over 2 years.
Randomized comparison of femoral closure devices including AngioSeal (anchor + collagen sponge) showed no device-related differences in systemic inflammatory markers; IL-6 rose at 6 hours in all groups.
Topical product containing collagen tripeptide improved objective skin barrier measures and reduced symptoms of sensitive atopic skin versus placebo over 4 weeks.
Randomized double-blind placebo-controlled trial: 5 g/day specific collagen peptides for 12 weeks reduced activity-related knee pain versus placebo in physically active young adults.
Randomized double-blind placebo-controlled trial: 5 g/day specific collagen peptides for 12 weeks reduced activity-related knee pain versus placebo in physically active young adults.
rhPDGF-BB combined with a β-TCP–collagen matrix (osteoconductive, calcium phosphate–based) produced higher fusion rates, faster time to fusion, and higher clinical success versus autograft in ankle/hindfoot fusions.
rhPDGF-BB combined with a β-TCP–collagen matrix (osteoconductive, calcium phosphate–based) produced higher fusion rates, faster time to fusion, and higher clinical success versus autograft in ankle/hindfoot fusions.
rhPDGF-BB combined with a β-TCP–collagen matrix (osteoconductive, calcium phosphate–based) produced higher fusion rates, faster time to fusion, and higher clinical success versus autograft in ankle/hindfoot fusions.
Ibandronate and alendronate both increased BMD over 1 year; all women also received daily calcium and vitamin D 200 IU.
In 96 uncontrolled hypertensive patients, antihypertensive treatment reduced MMP-9 and increased TIMP-1, indicating altered collagen/ECM turnover after therapy.
In 96 uncontrolled hypertensive patients, antihypertensive treatment reduced MMP-9 and increased TIMP-1, indicating altered collagen/ECM turnover after therapy.
In 78 overweight schizophrenia patients with prediabetes, 16 weeks of liraglutide did not change bone turnover markers (CTX, P1NP) versus placebo.
In 78 overweight schizophrenia patients with prediabetes, 16 weeks of liraglutide did not change bone turnover markers (CTX, P1NP) versus placebo.
12-week randomized dietary supplement trial in adults with abdominal obesity; whey protein increased urinary calcium but did not change bone turnover markers or BMD.
In 77 men with bone-metastatic prostate cancer on zoledronic acid, most bone turnover markers fell after treatment; several markers were higher in patients with progressive bone disease.
In 31 stable chronic heart failure patients, spironolactone reduced a circulating procollagen III peptide and improved heart rate variability and early-morning heart rate.
In 31 stable chronic heart failure patients, spironolactone reduced a circulating procollagen III peptide and improved heart rate variability and early-morning heart rate.
In 31 stable chronic heart failure patients, spironolactone reduced a circulating procollagen III peptide and improved heart rate variability and early-morning heart rate.
In 585 RA patients, serum C1M (MMP-degraded type I collagen) correlated with disease activity and predicted radiographic progression; tocilizumab dose-dependently reduced C1M (rapid ~49% drop at 2 weeks with sustained lowering at higher dose).
In 585 RA patients, serum C1M (MMP-degraded type I collagen) correlated with disease activity and predicted radiographic progression; tocilizumab dose-dependently reduced C1M (rapid ~49% drop at 2 weeks with sustained lowering at higher dose).
Multicenter randomized trial of once-weekly alendronate in postmenopausal Chinese women; not designed to test Vitamin D effects.
Randomized substudy comparing tamoxifen, exemestane, and anastrozole over 2 years; tamoxifen was associated with lower bone turnover markers (NTX and BAP) versus the two aromatase inhibitors, with BMD trends favoring tamoxifen though not always significant.
Lower baseline PRO-C2 (a marker of type II collagen formation) identifies patients with faster radiographic knee OA progression and higher odds of progression.
Lower baseline PRO-C2 (a marker of type II collagen formation) identifies patients with faster radiographic knee OA progression and higher odds of progression.
Lower baseline PRO-C2 (a marker of type II collagen formation) identifies patients with faster radiographic knee OA progression and higher odds of progression.
High levels of a collagen breakdown marker (NTX) predicted worse bone outcomes and death; zoledronic acid reduced mortality risk in patients with high NTX.
High levels of a collagen breakdown marker (NTX) predicted worse bone outcomes and death; zoledronic acid reduced mortality risk in patients with high NTX.
A daily combined massage and physical activity protocol increased a serum bone formation marker but did not reduce markers of bone resorption in preterm infants.
A daily combined massage and physical activity protocol increased a serum bone formation marker but did not reduce markers of bone resorption in preterm infants.
Tocilizumab monotherapy reduced 1‑year radiographic erosion and joint‑space narrowing most markedly in patients classified as high‑risk by collagen and other biomarkers.
Tocilizumab monotherapy reduced 1‑year radiographic erosion and joint‑space narrowing most markedly in patients classified as high‑risk by collagen and other biomarkers.
In Mexican postmenopausal women with osteoporosis, bazedoxifene markedly reduced bone turnover markers including a collagen resorption marker versus placebo at 12 months.
High serum bone turnover markers (including collagen‑related markers) predicted much worse survival in CRPC with bone metastases; a small high‑marker subgroup derived survival benefit from atrasentan.
High serum bone turnover markers (including collagen‑related markers) predicted much worse survival in CRPC with bone metastases; a small high‑marker subgroup derived survival benefit from atrasentan.
Measured circulating collagen neo-peptides in patients with metastatic pancreatic cancer and found that a high C3M/PRO-C3 ratio predicted better response (PFS, OS, ORR) to pegvorhyaluronidase alfa plus chemotherapy.
Measured circulating collagen neo-peptides in patients with metastatic pancreatic cancer and found that a high C3M/PRO-C3 ratio predicted better response (PFS, OS, ORR) to pegvorhyaluronidase alfa plus chemotherapy.
Four weeks of an oral supplement containing hydrolyzed collagen type II plus HA and CS reduced pain scores and decreased some inflammatory cytokines in synovial fluid of knee OA patients.
Four weeks of an oral supplement containing hydrolyzed collagen type II plus HA and CS reduced pain scores and decreased some inflammatory cytokines in synovial fluid of knee OA patients.
Risedronate plus calcium reduced objective pain measure and was associated with a decrease in urinary type II collagen fragments compared with calcium alone.
Risedronate plus calcium reduced objective pain measure and was associated with a decrease in urinary type II collagen fragments compared with calcium alone.
Six months of low-dose roxithromycin reduced airway inflammation, sputum type IV collagen, airway wall thickness, and exacerbations versus control.
Six months of low-dose roxithromycin reduced airway inflammation, sputum type IV collagen, airway wall thickness, and exacerbations versus control.
Six months of low-dose roxithromycin reduced airway inflammation, sputum type IV collagen, airway wall thickness, and exacerbations versus control.
Alendronate suppressed bone turnover (NTX, ALP) more than elcatonin and produced greater reductions in back pain and improved quality of life over 6 months.
Alendronate suppressed bone turnover (NTX, ALP) more than elcatonin and produced greater reductions in back pain and improved quality of life over 6 months.
Alendronate suppressed bone turnover (NTX, ALP) more than elcatonin and produced greater reductions in back pain and improved quality of life over 6 months.
Two years of transdermal DHT did not affect prostate growth but increased the aminoterminal propeptide of type I procollagen and altered body composition and blood parameters.
Two years of transdermal DHT did not affect prostate growth but increased the aminoterminal propeptide of type I procollagen and altered body composition and blood parameters.
Two years of transdermal DHT did not affect prostate growth but increased the aminoterminal propeptide of type I procollagen and altered body composition and blood parameters.
Drinking bicarbonate-rich (alkaline) mineral water for 2–4 weeks reduced serum CTX and PTH compared with an acidic calcium-rich water in young women.
Spironolactone reduced ventricular extrasystoles, shortened QT interval, and lowered a collagen synthesis marker (PIIINP) in ischemic heart disease patients without heart failure.
Spironolactone reduced ventricular extrasystoles, shortened QT interval, and lowered a collagen synthesis marker (PIIINP) in ischemic heart disease patients without heart failure.
Spironolactone reduced ventricular extrasystoles, shortened QT interval, and lowered a collagen synthesis marker (PIIINP) in ischemic heart disease patients without heart failure.
A 6-month randomized trial found the product containing undenatured type II collagen (Artneo) improved pain, stiffness, and some MRI signs of synovitis and was not inferior to glucosamine+chondroitin.
A 6-month randomized trial found the product containing undenatured type II collagen (Artneo) improved pain, stiffness, and some MRI signs of synovitis and was not inferior to glucosamine+chondroitin.
A multicenter randomized double-blind trial of undenatured type II collagen (UC-II) in knee OA (mITT n=186) showed significant reductions in total WOMAC and subscale scores, less rescue medication use, and was well tolerated.
A multicenter randomized double-blind trial of undenatured type II collagen (UC-II) in knee OA (mITT n=186) showed significant reductions in total WOMAC and subscale scores, less rescue medication use, and was well tolerated.
A multicenter randomized double-blind trial of undenatured type II collagen (UC-II) in knee OA (mITT n=186) showed significant reductions in total WOMAC and subscale scores, less rescue medication use, and was well tolerated.
Pyridoxamine tended to raise a bone formation marker, increased femoral neck BMD, and slightly lowered HbA1c in older women with T2D.
Randomized double-blind 30-day trial (67 completers) found Aflapin reduced knee pain and improved function; collagen type II cleavage biomarker (C2C) and inflammatory biomarkers decreased.
IFN-beta-1a therapy reduced liver inflammation, fibrosis, and collagen III levels in patients with chronic hepatitis C.
IFN-beta-1a therapy reduced liver inflammation, fibrosis, and collagen III levels in patients with chronic hepatitis C.
IFN-beta-1a therapy reduced liver inflammation, fibrosis, and collagen III levels in patients with chronic hepatitis C.
In AGHD patients receiving GH replacement, adding oral phosphate or alendronate increased markers of bone activity and produced greater BMD increases compared with GH alone; vitamin D was not studied.
In AGHD patients receiving GH replacement, adding oral phosphate or alendronate increased markers of bone activity and produced greater BMD increases compared with GH alone; vitamin D was not studied.
Combination lisinopril+verapamil reduced angiogenic markers and albuminuria in hypertensive T2DM patients with microalbuminuria.
Combination lisinopril+verapamil reduced angiogenic markers and albuminuria in hypertensive T2DM patients with microalbuminuria.
Combination lisinopril+verapamil reduced angiogenic markers and albuminuria in hypertensive T2DM patients with microalbuminuria.
Zoledronic acid produced larger reductions in type I collagen resorption marker and bone formation marker than raloxifene in postmenopausal women with low bone density.
Zoledronic acid produced larger reductions in type I collagen resorption marker and bone formation marker than raloxifene in postmenopausal women with low bone density.
In athletes with early knee arthritis, 12 weeks of collagen supplementation reduced pain from baseline but was not superior to exercise; combined collagen+exercise improved several functional outcomes.
Placebo-controlled RCT of AR7 (contains sternum collagen type II among other ingredients) for 3 months showed reduced joint pain and improved body pain scores.
Placebo-controlled RCT of AR7 (contains sternum collagen type II among other ingredients) for 3 months showed reduced joint pain and improved body pain scores.
Placebo-controlled RCT of AR7 (contains sternum collagen type II among other ingredients) for 3 months showed reduced joint pain and improved body pain scores.
In a cross-sectional analysis of participants from the VIDEO trial (n≈447 with serum data; n=136 with CE‑MRI), site-specific CE‑MRI synovitis (medial perimeniscal, suprapatellar) associated with worse knee pain/function, and certain serum matrix-turnover markers (C3M, CRPM) showed negative associations with pain.
In a cross-sectional analysis of participants from the VIDEO trial (n≈447 with serum data; n=136 with CE‑MRI), site-specific CE‑MRI synovitis (medial perimeniscal, suprapatellar) associated with worse knee pain/function, and certain serum matrix-turnover markers (C3M, CRPM) showed negative associations with pain.
In a cross-sectional analysis of participants from the VIDEO trial (n≈447 with serum data; n=136 with CE‑MRI), site-specific CE‑MRI synovitis (medial perimeniscal, suprapatellar) associated with worse knee pain/function, and certain serum matrix-turnover markers (C3M, CRPM) showed negative associations with pain.
In dialysis patients with early secondary hyperparathyroidism, intermittent intravenous calcitriol prevented parathyroid gland enlargement compared with daily oral calcitriol over 12 months.
In dialysis patients with early secondary hyperparathyroidism, intermittent intravenous calcitriol prevented parathyroid gland enlargement compared with daily oral calcitriol over 12 months.
In people with type 2 diabetes, higher circulating PIIINP marks expanded visceral fat and an inflammatory adipose-tissue profile.
In people with type 2 diabetes, higher circulating PIIINP marks expanded visceral fat and an inflammatory adipose-tissue profile.
In people with type 2 diabetes, higher circulating PIIINP marks expanded visceral fat and an inflammatory adipose-tissue profile.
Among breast cancer patients with bone metastases, early normalization of urinary NTX during zoledronic acid therapy was linked to fewer skeletal events and lower mortality.
Among breast cancer patients with bone metastases, early normalization of urinary NTX during zoledronic acid therapy was linked to fewer skeletal events and lower mortality.
Bazedoxifene/conjugated estrogens increased spine and hip bone mineral density and reduced bone turnover markers versus placebo in postmenopausal women at risk for osteoporosis.
Shockwave lithotripsy caused prolonged increases in a urinary renal fibrosis marker (PIIINP) for up to ~18 months and modest persistent serum creatinine elevation at 2 years.
Shockwave lithotripsy caused prolonged increases in a urinary renal fibrosis marker (PIIINP) for up to ~18 months and modest persistent serum creatinine elevation at 2 years.
In 200 CRF patients randomized to autologous MSCs vs N-acetylcysteine, MSCs produced greater improvements in renal function markers and oxidative stress over 8 weeks.
Shockwave lithotripsy caused prolonged increases in a urinary renal fibrosis marker (PIIINP) for up to ~18 months and modest persistent serum creatinine elevation at 2 years.
In GH-deficient adults, IGF-I and GH therapy produced distinct changes in bone alkaline phosphatase isoforms and increased several bone turnover markers, indicating stimulation of type I collagen synthesis.
In GH-deficient adults, IGF-I and GH therapy produced distinct changes in bone alkaline phosphatase isoforms and increased several bone turnover markers, indicating stimulation of type I collagen synthesis.
In GH-deficient adults, IGF-I and GH therapy produced distinct changes in bone alkaline phosphatase isoforms and increased several bone turnover markers, indicating stimulation of type I collagen synthesis.
In patients with elevated urinary N-telopeptide despite IV bisphosphonates, denosumab more frequently normalized uNTx and was associated with fewer on-study SREs than continuing IV bisphosphonates.
In patients with elevated urinary N-telopeptide despite IV bisphosphonates, denosumab more frequently normalized uNTx and was associated with fewer on-study SREs than continuing IV bisphosphonates.
Observational cohort (n=142) showing higher baseline serum PIIINP (type III procollagen N-peptide) in patients with AF recurrence and that PIIINP independently predicted recurrence after cardioversion.
Randomized study in 93 AMI patients undergoing PCI reporting that Shenfu injection (plus PCI) reduced post-AMI rise in BNP versus PCI alone and was interpreted as ameliorating myocardial injury and preventing fibrosis.
In osteopenic postmenopausal women receiving calcium/magnesium/calcitriol, red clover extract plus probiotics reduced lumbar spine BMD loss and improved bone turnover and estrogen metabolite profile versus placebo.
In osteopenic postmenopausal women receiving calcium/magnesium/calcitriol, red clover extract plus probiotics reduced lumbar spine BMD loss and improved bone turnover and estrogen metabolite profile versus placebo.
In 35 HFpEF patients with diabetes, 9 months of torasemide did not change serum PIP compared with furosemide — no effect on collagen synthesis marker or clinical measures.
In 35 HFpEF patients with diabetes, 9 months of torasemide did not change serum PIP compared with furosemide — no effect on collagen synthesis marker or clinical measures.
Ossein-hydroxyapatite compound (contains collagen) slowed peripheral trabecular bone loss more than calcium carbonate over 20 months in postmenopausal osteoporotic women.
Ancillary case–control analysis (n=166) found higher second-trimester amniotic fluid procollagen, osteopontin, IL-19 and increased positive IL-33 and TNFα in women who later had spontaneous preterm birth, especially late preterm.
Ancillary case–control analysis (n=166) found higher second-trimester amniotic fluid procollagen, osteopontin, IL-19 and increased positive IL-33 and TNFα in women who later had spontaneous preterm birth, especially late preterm.
Ancillary case–control analysis (n=166) found higher second-trimester amniotic fluid procollagen, osteopontin, IL-19 and increased positive IL-33 and TNFα in women who later had spontaneous preterm birth, especially late preterm.
Ancillary case–control analysis (n=166) found higher second-trimester amniotic fluid procollagen, osteopontin, IL-19 and increased positive IL-33 and TNFα in women who later had spontaneous preterm birth, especially late preterm.
Ancillary case–control analysis (n=166) found higher second-trimester amniotic fluid procollagen, osteopontin, IL-19 and increased positive IL-33 and TNFα in women who later had spontaneous preterm birth, especially late preterm.
Observational cohort (n=142) showing higher baseline serum PIIINP (type III procollagen N-peptide) in patients with AF recurrence and that PIIINP independently predicted recurrence after cardioversion.
Randomized double-blind trial in women >60: yogurt fortified with vitamin D3 (400 IU) and additional calcium increased 25OHD and decreased PTH and bone resorption markers over 12 weeks.
Randomized double-blind trial in women >60: yogurt fortified with vitamin D3 (400 IU) and additional calcium increased 25OHD and decreased PTH and bone resorption markers over 12 weeks.
Twelve-week randomized study: calcium- and vitamin D–fortified milk (higher calcium + vitamin D + FOS-inulin) reduced bone resorption markers and PTH more than regular milk, especially in postmenopausal women.
Randomized double-blind trial in women >60: yogurt fortified with vitamin D3 (400 IU) and additional calcium increased 25OHD and decreased PTH and bone resorption markers over 12 weeks.
Twelve-week randomized study: calcium- and vitamin D–fortified milk (higher calcium + vitamin D + FOS-inulin) reduced bone resorption markers and PTH more than regular milk, especially in postmenopausal women.
Twelve-week randomized study: calcium- and vitamin D–fortified milk (higher calcium + vitamin D + FOS-inulin) reduced bone resorption markers and PTH more than regular milk, especially in postmenopausal women.
Randomized study in 93 AMI patients undergoing PCI reporting that Shenfu injection (plus PCI) reduced post-AMI rise in BNP versus PCI alone and was interpreted as ameliorating myocardial injury and preventing fibrosis.
Adding Korean Red Ginseng to antiviral therapy in chronic hepatitis B reduced some non‑invasive fibrosis markers (hyaluronic acid and TGF‑β) compared with antivirals alone.
In 200 CRF patients randomized to autologous MSCs vs N-acetylcysteine, MSCs produced greater improvements in renal function markers and oxidative stress over 8 weeks.
In >1,100 HFpEF patients sacubitril/valsartan (vs valsartan) favorably altered circulating extracellular matrix/collagen-related biomarkers at 16 weeks.
In post-MI patients, eplerenone lowered a blood marker of collagen turnover (PIIINP) when baseline levels were high.
Eight weeks of budesonide produced higher short-term clinical response and reduced lamina propria inflammatory infiltrate in collagenous colitis.
Eight weeks of budesonide produced higher short-term clinical response and reduced lamina propria inflammatory infiltrate in collagenous colitis.
Eight weeks of budesonide produced higher short-term clinical response and reduced lamina propria inflammatory infiltrate in collagenous colitis.
Topical DHEA increased androgen receptor expression and procollagen (type I and III) mRNA in skin of postmenopausal women.
Topical DHEA increased androgen receptor expression and procollagen (type I and III) mRNA in skin of postmenopausal women.
Topical DHEA increased androgen receptor expression and procollagen (type I and III) mRNA in skin of postmenopausal women.
Twelve months of high-impact exercise lowered basal serum PTH but did not change bone turnover markers in premenopausal women.
Twelve months of high-impact exercise lowered basal serum PTH but did not change bone turnover markers in premenopausal women.
All patients received vitamin D3 and calcium; HRT (vs no HRT) decreased serum sRAGE and associated with increased BMD and reduced bone/cartilage turnover.
All patients received vitamin D3 and calcium; HRT (vs no HRT) decreased serum sRAGE and associated with increased BMD and reduced bone/cartilage turnover.
All patients received vitamin D3 and calcium; HRT (vs no HRT) decreased serum sRAGE and associated with increased BMD and reduced bone/cartilage turnover.
Randomized study in NSCLC patients found recombinant human endostatin (a collagen-derived fragment) given during a normalization window with radiotherapy increased response rates and median survival versus radiotherapy alone, but did not significantly improve long-term overall survival.
Randomized study in NSCLC patients found recombinant human endostatin (a collagen-derived fragment) given during a normalization window with radiotherapy increased response rates and median survival versus radiotherapy alone, but did not significantly improve long-term overall survival.
Randomized study in NSCLC patients found recombinant human endostatin (a collagen-derived fragment) given during a normalization window with radiotherapy increased response rates and median survival versus radiotherapy alone, but did not significantly improve long-term overall survival.
Bovine pericardial membrane placed after parotidectomy reduced Frey's syndrome compared with SMAS flap at 12-month follow-up.
Bovine pericardial membrane placed after parotidectomy reduced Frey's syndrome compared with SMAS flap at 12-month follow-up.
Application of a fibrinogen/thrombin-coated collagen patch did not significantly reduce clinically relevant pancreatic fistulas or hospital stay.
Randomized trial of 36 necrotic teeth using four scaffolds (periapical bleeding, PRF, collagen, hydroxyapatite); collagen scaffold showed intermediate rates of cold-test sensibility recovery and all groups had good radiographic periapical healing at 12 months.
Randomized trial of 36 necrotic teeth using four scaffolds (periapical bleeding, PRF, collagen, hydroxyapatite); collagen scaffold showed intermediate rates of cold-test sensibility recovery and all groups had good radiographic periapical healing at 12 months.
Use of Bio‑Oss Collagen with early implant placement (8–10 weeks) preserved alveolar bone levels better than collagen alone or no treatment.
Use of Bio‑Oss Collagen with early implant placement (8–10 weeks) preserved alveolar bone levels better than collagen alone or no treatment.
In athletes with early knee arthritis, 12 weeks of collagen supplementation reduced pain from baseline but was not superior to exercise; combined collagen+exercise improved several functional outcomes.
Randomized trial found collagen hemostatic sponge reduced postoperative drainage volume and calculated drainage blood compared with gelatin sponge in posterior lumbar fusion.
Randomized trial found collagen hemostatic sponge reduced postoperative drainage volume and calculated drainage blood compared with gelatin sponge in posterior lumbar fusion.
Randomized trial found collagen hemostatic sponge reduced postoperative drainage volume and calculated drainage blood compared with gelatin sponge in posterior lumbar fusion.
In a randomized trial of diabetic foot ulcers, collagen dressings had longer median time-to-heal and lower 12‑week healing rates than PLA matrices.
In a randomized trial of diabetic foot ulcers, collagen dressings had longer median time-to-heal and lower 12‑week healing rates than PLA matrices.
Adding an oral supplement containing hydrolysed marine collagen plus amino acids and micronutrients to standard hair-loss treatments improved blinded clinician-rated hair outcomes over 12 weeks versus treatments alone and was well tolerated.
Adding an oral supplement containing hydrolysed marine collagen plus amino acids and micronutrients to standard hair-loss treatments improved blinded clinician-rated hair outcomes over 12 weeks versus treatments alone and was well tolerated.
Adding an oral supplement containing hydrolysed marine collagen plus amino acids and micronutrients to standard hair-loss treatments improved blinded clinician-rated hair outcomes over 12 weeks versus treatments alone and was well tolerated.
Both percutaneous collagen induction and focal 100% TCA (CROSS) improved atrophic acne scars substantially; no significant difference between the two methods.
Randomized clinical study (60 patients) comparing PRF, PRF+collagen plug, and control after tooth extraction; evaluated ridge dimensions and postoperative pain.
Randomized clinical trial (63 enrolled, 58 available for follow-up) comparing apically positioned flap, free gingival graft (FGG), and a collagen matrix to increase keratinized mucosa before implant prosthesis; outcomes at 4 weeks.
Topical meristem-cell-based serums applied for 4 weeks improved skin hydration, elasticity and increased dermal collagen markers (hydroxyproline) with reduced lipid peroxidation.
Topical meristem-cell-based serums applied for 4 weeks improved skin hydration, elasticity and increased dermal collagen markers (hydroxyproline) with reduced lipid peroxidation.
Compared collagen-stabilized bovine bone (ABBM-C) to composite graft (ABBM+autogenous bone) for sinus augmentation; similar new bone but ABBM-C showed lower osseointegration and less mature bone in some zones.
Compared collagen-stabilized bovine bone (ABBM-C) to composite graft (ABBM+autogenous bone) for sinus augmentation; similar new bone but ABBM-C showed lower osseointegration and less mature bone in some zones.
Compared collagen-stabilized bovine bone (ABBM-C) to composite graft (ABBM+autogenous bone) for sinus augmentation; similar new bone but ABBM-C showed lower osseointegration and less mature bone in some zones.
Multicenter randomized trial: intraoperative collagen-fibrin patch did not reduce symptomatic or asymptomatic lymphocele rates after pelvic lymphadenectomy.
Multicenter randomized trial: intraoperative collagen-fibrin patch did not reduce symptomatic or asymptomatic lymphocele rates after pelvic lymphadenectomy.
Randomized triple-blind trial: plasma (argon) cleaning of titanium abutments increased cell-covered area, altered collagen fiber density/orientation, and reduced contamination versus untreated abutments.
Randomized triple-blind trial: plasma (argon) cleaning of titanium abutments increased cell-covered area, altered collagen fiber density/orientation, and reduced contamination versus untreated abutments.
RCT comparing FDBA + collagen membrane versus combined FDBA+autogenous bone + collagen membrane for horizontal ridge augmentation: both produced significant ridge width gains with no difference in new bone amount or connective tissue.
RCT comparing FDBA + collagen membrane versus combined FDBA+autogenous bone + collagen membrane for horizontal ridge augmentation: both produced significant ridge width gains with no difference in new bone amount or connective tissue.
After HA injection, adding an oral collagen-containing viscosupplement tended to improve symptoms and reduced patients' use of painkillers more than HA alone.
Glucocorticoid (oral ± local injection) treatment after esophageal ESD reduced post‑operative stenosis and lowered TGF‑β1 and collagen‑I expression in mucosal tissue.
Glucocorticoid (oral ± local injection) treatment after esophageal ESD reduced post‑operative stenosis and lowered TGF‑β1 and collagen‑I expression in mucosal tissue.
Glucocorticoid (oral ± local injection) treatment after esophageal ESD reduced post‑operative stenosis and lowered TGF‑β1 and collagen‑I expression in mucosal tissue.
TTFCA treatment (60 mg TID) for 12 months increased femoral plaque echogenicity (GSM) and homogeneity, consistent with increased collagen/stroma within plaques and plaque stabilization.
TTFCA treatment (60 mg TID) for 12 months increased femoral plaque echogenicity (GSM) and homogeneity, consistent with increased collagen/stroma within plaques and plaque stabilization.
TTFCA treatment (60 mg TID) for 12 months increased femoral plaque echogenicity (GSM) and homogeneity, consistent with increased collagen/stroma within plaques and plaque stabilization.
Both microneedling and fractional CO2 laser improved scar clinical scores and histochemical collagen/elastin; fractional CO2 laser produced larger increases in collagen (neocollagenesis).
Both microneedling and fractional CO2 laser improved scar clinical scores and histochemical collagen/elastin; fractional CO2 laser produced larger increases in collagen (neocollagenesis).
Adding topical PRP to fractional laser improved patient satisfaction, increased skin elasticity, collagen amount, and fibroblast number on biopsy compared with laser alone.
Adding topical PRP to fractional laser improved patient satisfaction, increased skin elasticity, collagen amount, and fibroblast number on biopsy compared with laser alone.
40 women randomized; treated group (Giovina supplement) over 4 months showed lower clinical aging score, reduced skin redness, and fewer visible wrinkles than controls.
40 women randomized; treated group (Giovina supplement) over 4 months showed lower clinical aging score, reduced skin redness, and fewer visible wrinkles than controls.
40 women randomized; treated group (Giovina supplement) over 4 months showed lower clinical aging score, reduced skin redness, and fewer visible wrinkles than controls.
60 patients randomized; primary closure over a gentamicin-impregnated collagen sponge led to less pain, faster healing, and lower overall cost than open excision, with similar 5-year recurrence.
60 patients randomized; primary closure over a gentamicin-impregnated collagen sponge led to less pain, faster healing, and lower overall cost than open excision, with similar 5-year recurrence.
60 patients randomized; primary closure over a gentamicin-impregnated collagen sponge led to less pain, faster healing, and lower overall cost than open excision, with similar 5-year recurrence.
In this randomized trial, covering customized titanium mesh with a resorbable (cross-linked collagen) membrane tended to reduce healing complications and improve regenerated bone volume compared with mesh alone, though differences were not statistically significant.
In this randomized trial, covering customized titanium mesh with a resorbable (cross-linked collagen) membrane tended to reduce healing complications and improve regenerated bone volume compared with mesh alone, though differences were not statistically significant.
In post-MI patients, measures of collagen-related biomarkers one month after MI predicted adverse LV remodeling and higher cardiovascular events over follow-up.
In post-MI patients, measures of collagen-related biomarkers one month after MI predicted adverse LV remodeling and higher cardiovascular events over follow-up.
In post-MI patients, measures of collagen-related biomarkers one month after MI predicted adverse LV remodeling and higher cardiovascular events over follow-up.
Randomized clinical trial (nested) in orthodontic patients: decortication and porcine 3D collagen matrix tended to shorten alignment/total treatment times, while IL‑1β allele 2 had no clear effect.
Randomized clinical trial (nested) in orthodontic patients: decortication and porcine 3D collagen matrix tended to shorten alignment/total treatment times, while IL‑1β allele 2 had no clear effect.
Randomized clinical trial (nested) in orthodontic patients: decortication and porcine 3D collagen matrix tended to shorten alignment/total treatment times, while IL‑1β allele 2 had no clear effect.
Split-face RCT in humans found both MFR+topical insulin and MFR+placebo significantly improved acne scars and scar volume; insulin produced earlier improvement but final outcomes were similar between sides.
Split-face RCT in humans found both MFR+topical insulin and MFR+placebo significantly improved acne scars and scar volume; insulin produced earlier improvement but final outcomes were similar between sides.
Randomized double-blind trial comparing isolated bioinductive repair (implant that induces collagen deposition) versus sutured repair for small/medium full-thickness rotator cuff tears: bioinductive repair yielded superior collagen organization, greater tendon thickness increase, 100% MRI healing at 12/24 months, better PROs and faster return to work.
Randomized double-blind trial comparing isolated bioinductive repair (implant that induces collagen deposition) versus sutured repair for small/medium full-thickness rotator cuff tears: bioinductive repair yielded superior collagen organization, greater tendon thickness increase, 100% MRI healing at 12/24 months, better PROs and faster return to work.
Randomized study of gentamicin-collagen implant vs control in CABG patients showed a small, nonsignificant reduction in sternal wound infections and mediastinitis with the implant; treatment was safe.
In older men doing home-based resistance exercise, obesity/metabolic risk reduced anabolic response; a higher-quality multi-ingredient supplement (which included calcium) produced better lean-mass, strength and bone marker outcomes than a lower-quality supplement.
In older men doing home-based resistance exercise, obesity/metabolic risk reduced anabolic response; a higher-quality multi-ingredient supplement (which included calcium) produced better lean-mass, strength and bone marker outcomes than a lower-quality supplement.
In older men doing home-based resistance exercise, obesity/metabolic risk reduced anabolic response; a higher-quality multi-ingredient supplement (which included calcium) produced better lean-mass, strength and bone marker outcomes than a lower-quality supplement.
Proof-of-principle randomized study of collagen scaffolds with/without autologous BM-MSCs for periodontal defects: all treatments led to significant clinical improvements over 12 months with no adverse healing events; radiographic bone fill was less in scaffold-only group.
Proof-of-principle randomized study of collagen scaffolds with/without autologous BM-MSCs for periodontal defects: all treatments led to significant clinical improvements over 12 months with no adverse healing events; radiographic bone fill was less in scaffold-only group.
Steroid pulses altered bone turnover markers; adding alendronate reduced steroid-induced bone resorption.
Steroid pulses altered bone turnover markers; adding alendronate reduced steroid-induced bone resorption.
Steroid pulses altered bone turnover markers; adding alendronate reduced steroid-induced bone resorption.
Adding calcitriol to esomeprazole did not improve bone mineral density; only minor changes in calcium and bone markers were observed.
Adding calcitriol to esomeprazole did not improve bone mineral density; only minor changes in calcium and bone markers were observed.
Biomarker sub-study of an RCT in RA showing tocilizumab reduces collagen-degradation biomarkers and CRP more than methotrexate by week 8.
Clustering of blood ECM (including collagen) biomarkers identified three patient endotypes with different disease activity and differential response to adalimumab.
Clustering of blood ECM (including collagen) biomarkers identified three patient endotypes with different disease activity and differential response to adalimumab.
Clustering of blood ECM (including collagen) biomarkers identified three patient endotypes with different disease activity and differential response to adalimumab.
All treatments improved symptoms short-term; heavy slow resistance training gave better long-term outcomes and increased collagen network turnover.
All treatments improved symptoms short-term; heavy slow resistance training gave better long-term outcomes and increased collagen network turnover.
All treatments improved symptoms short-term; heavy slow resistance training gave better long-term outcomes and increased collagen network turnover.
Inflammatory hand OA patients showed biomarker variation; prednisolone did not change most collagen-related biomarkers over 6 weeks.
Inflammatory hand OA patients showed biomarker variation; prednisolone did not change most collagen-related biomarkers over 6 weeks.
Prospective randomized pilot study testing alveolar ridge preservation with DBBM (particulate) or DBBM-C (DBBM stabilized in 10% porcine type I collagen) versus unassisted healing; ARP maintained mid-ridge height and reduced sinus pneumatization and the need for lateral sinus augmentation.
Prospective randomized pilot study testing alveolar ridge preservation with DBBM (particulate) or DBBM-C (DBBM stabilized in 10% porcine type I collagen) versus unassisted healing; ARP maintained mid-ridge height and reduced sinus pneumatization and the need for lateral sinus augmentation.
Prospective randomized pilot study testing alveolar ridge preservation with DBBM (particulate) or DBBM-C (DBBM stabilized in 10% porcine type I collagen) versus unassisted healing; ARP maintained mid-ridge height and reduced sinus pneumatization and the need for lateral sinus augmentation.
Double-blind randomized trial of tretinoin 0.05% lotion vs vehicle (vehicle contained soluble collagen among other hydrators) for chest photorejuvenation; both active and vehicle groups improved similarly by 180 days with mild, transient erythema higher in active at day 90.
Randomized clinical trial comparing collagen plug, demineralized bone matrix (Grafton) and particulate autogenous+DBBM (MinerOss X) with vestibular socket therapy in immediate implants; all groups had good esthetic outcomes and increased facial bone thickness, with no significant differences between groups.
Randomized clinical trial comparing collagen plug, demineralized bone matrix (Grafton) and particulate autogenous+DBBM (MinerOss X) with vestibular socket therapy in immediate implants; all groups had good esthetic outcomes and increased facial bone thickness, with no significant differences between groups.
Randomized clinical trial comparing flapped vs flapless socket grafting with porcine bone and collagen membrane found similar histological outcomes after 3 months.
Randomized double-blind trial of a multi-nutrient supplement (including collagen type II) vs placebo for lumbar osteochondrosis; no differences in patient-reported outcomes, but supplement group showed significant increases in 3D-measured intervertebral disc (IVD) volumes.
A mineralized cancellous allograft (with or without a collagen membrane) improved vertical bone fill versus open flap debridement in mandibular Class II furcation defects.
A mineralized cancellous allograft (with or without a collagen membrane) improved vertical bone fill versus open flap debridement in mandibular Class II furcation defects.
At 1 month collagen matrix sealing showed greater early buccal volumetric loss than customized abutments, but at 1 year there were no significant differences between groups.
At 1 month collagen matrix sealing showed greater early buccal volumetric loss than customized abutments, but at 1 year there were no significant differences between groups.
At 1 month collagen matrix sealing showed greater early buccal volumetric loss than customized abutments, but at 1 year there were no significant differences between groups.
2 months of simvastatin (40 mg/day) in hypercholesterolemic patients reduced multiple inflammatory markers and platelet aggregation and increased platelet sensitivity to aspirin.
2 months of simvastatin (40 mg/day) in hypercholesterolemic patients reduced multiple inflammatory markers and platelet aggregation and increased platelet sensitivity to aspirin.
2 months of simvastatin (40 mg/day) in hypercholesterolemic patients reduced multiple inflammatory markers and platelet aggregation and increased platelet sensitivity to aspirin.
In this RCT of early implant placement, use of a collagen-containing ARP material produced similar one-year esthetic, clinical and patient-reported outcomes compared with ARP with palatal graft or no ARP.
In this RCT of early implant placement, use of a collagen-containing ARP material produced similar one-year esthetic, clinical and patient-reported outcomes compared with ARP with palatal graft or no ARP.
Randomized clinical study of two graft materials with the same collagen barrier showed 100% implant survival and similar clinical and radiographic outcomes at 1-year post-loading.
In this RCT of early implant placement, use of a collagen-containing ARP material produced similar one-year esthetic, clinical and patient-reported outcomes compared with ARP with palatal graft or no ARP.
Compared two xenograft ridge-preservation protocols in humans; the protocol using a cross-linked bovine collagen sponge produced more vital bone than the other, while clinical dimensional changes were similar.
Randomized trial comparing electrocautery plus a collagen patch sealant versus stapler for lobectomy; the collagen-patch group had fewer and shorter air leaks and lower costs.
Randomized trial comparing electrocautery plus a collagen patch sealant versus stapler for lobectomy; the collagen-patch group had fewer and shorter air leaks and lower costs.
Randomized trial comparing electrocautery plus a collagen patch sealant versus stapler for lobectomy; the collagen-patch group had fewer and shorter air leaks and lower costs.
RCT comparing no graft, connective tissue graft, and xenogeneic collagen matrix at implant placement; no significant differences in esthetic outcomes or peri-implant health at 12 months.
RCT comparing no graft, connective tissue graft, and xenogeneic collagen matrix at implant placement; no significant differences in esthetic outcomes or peri-implant health at 12 months.
Randomized blinded trial of a collagen sponge coated with human coagulation factors after axillary lymphadenectomy; use was associated with a lower incidence of postoperative seroma.
Randomized double-blind trial of a multi-nutrient supplement (including collagen type II) vs placebo for lumbar osteochondrosis; no differences in patient-reported outcomes, but supplement group showed significant increases in 3D-measured intervertebral disc (IVD) volumes.
Randomized double-blind trial of a multi-nutrient supplement (including collagen type II) vs placebo for lumbar osteochondrosis; no differences in patient-reported outcomes, but supplement group showed significant increases in 3D-measured intervertebral disc (IVD) volumes.
In this randomized double-blind placebo-controlled trial, injections of collagenase improved clinician- and patient-rated cellulite severity and patient satisfaction versus placebo and were generally well tolerated.
In this randomized double-blind placebo-controlled trial, injections of collagenase improved clinician- and patient-rated cellulite severity and patient satisfaction versus placebo and were generally well tolerated.
In this randomized double-blind placebo-controlled trial, injections of collagenase improved clinician- and patient-rated cellulite severity and patient satisfaction versus placebo and were generally well tolerated.
In 39 patients with atrophic acne scars, combined alternating sessions of fractional laser and percutaneous collagen induction + TCA produced greater mean scar‑severity improvement than either treatment alone.
In 39 patients with atrophic acne scars, combined alternating sessions of fractional laser and percutaneous collagen induction + TCA produced greater mean scar‑severity improvement than either treatment alone.
In 39 patients with atrophic acne scars, combined alternating sessions of fractional laser and percutaneous collagen induction + TCA produced greater mean scar‑severity improvement than either treatment alone.
Randomized trial of sandwich bone augmentation with a collagen (bovine pericardium) barrier membrane showed preserved bone volume but delayed outer-layer maturation and less mineralization versus no membrane.
Both techniques (non-resorbable membrane vs titanium mesh + collagen membrane) produced ~30% newly formed bone by micro-CT with no significant differences between groups.
Daily C. rabens extract (180 mg) for 4 weeks improved several skin-aging measures including reduced wrinkles and increased collagen-associated parameters compared with placebo.
Daily C. rabens extract (180 mg) for 4 weeks improved several skin-aging measures including reduced wrinkles and increased collagen-associated parameters compared with placebo.
Alendronate prevented periprosthetic BMD loss around femoral implants and reduced serum N-terminal telopeptides of type-1 collagen; alfacalcidol preserved lumbar spine BMD but did not prevent periprosthetic loss.
Treatment with acellular porcine dermis (PD) or polynucleotides-added hyaluronic acid (PAHA) healed chronic ulcers faster and increased markers of tissue repair compared with polyurethane foam.
Treatment with acellular porcine dermis (PD) or polynucleotides-added hyaluronic acid (PAHA) healed chronic ulcers faster and increased markers of tissue repair compared with polyurethane foam.
Treatment with acellular porcine dermis (PD) or polynucleotides-added hyaluronic acid (PAHA) healed chronic ulcers faster and increased markers of tissue repair compared with polyurethane foam.
Grafting fresh extraction sockets with Bio-Oss Collagen largely preserved cross-sectional ridge area compared with no grafting over 4 months.
Grafting fresh extraction sockets with Bio-Oss Collagen largely preserved cross-sectional ridge area compared with no grafting over 4 months.
Grafting fresh extraction sockets with Bio-Oss Collagen largely preserved cross-sectional ridge area compared with no grafting over 4 months.
Sixty women randomized to topical peptides, oral hydrolyzed collagen, or placebo: oral collagen improved skin elasticity, increased dermis echogenicity, and reduced pores after 90 days.
Sixty women randomized to topical peptides, oral hydrolyzed collagen, or placebo: oral collagen improved skin elasticity, increased dermis echogenicity, and reduced pores after 90 days.
Sixty women randomized to topical peptides, oral hydrolyzed collagen, or placebo: oral collagen improved skin elasticity, increased dermis echogenicity, and reduced pores after 90 days.
Analysis of serum collagen-related ECM markers (eg, Pro-C3) in PSC patients showing correlations with fibrosis stage and prognosis.
Analysis of serum collagen-related ECM markers (eg, Pro-C3) in PSC patients showing correlations with fibrosis stage and prognosis.
Analysis of serum collagen-related ECM markers (eg, Pro-C3) in PSC patients showing correlations with fibrosis stage and prognosis.
Large multicenter randomized trial testing gentamicin-collagen sponge versus no sponge to prevent sternal wound infection in high-risk cardiac surgery patients.
Large multicenter randomized trial testing gentamicin-collagen sponge versus no sponge to prevent sternal wound infection in high-risk cardiac surgery patients.
Large multicenter randomized trial testing gentamicin-collagen sponge versus no sponge to prevent sternal wound infection in high-risk cardiac surgery patients.
Randomized human trial comparing coronally advanced flap (CAF) with or without a xenogeneic collagen matrix (CMX): adding CMX produced slightly greater objective SEI change but differences were not statistically significant at 1 year.
Randomized human trial comparing coronally advanced flap (CAF) with or without a xenogeneic collagen matrix (CMX): adding CMX produced slightly greater objective SEI change but differences were not statistically significant at 1 year.
Randomized human study: grafting sockets with collagenated bovine-derived bone plus collagen membrane markedly reduced horizontal shrinkage and volume loss versus spontaneous healing at 12 months.
Randomized human study: grafting sockets with collagenated bovine-derived bone plus collagen membrane markedly reduced horizontal shrinkage and volume loss versus spontaneous healing at 12 months.
Using a collagenated bovine bone mineral and a resorbable collagen membrane for ridge preservation reduced post-extraction ridge shrinkage and volumetric loss compared with spontaneous healing.
Randomized human study: grafting sockets with collagenated bovine-derived bone plus collagen membrane markedly reduced horizontal shrinkage and volume loss versus spontaneous healing at 12 months.
A topical eye cream (56 days, 33 women) increased collagen IV and elastin markers ex vivo and reduced periorbital wrinkle depth and improved hydration instrumentally and clinically.
A topical eye cream (56 days, 33 women) increased collagen IV and elastin markers ex vivo and reduced periorbital wrinkle depth and improved hydration instrumentally and clinically.
A topical eye cream (56 days, 33 women) increased collagen IV and elastin markers ex vivo and reduced periorbital wrinkle depth and improved hydration instrumentally and clinically.
Topical DHEA increased expression of multiple collagen genes and altered keratinocyte-related genes in postmenopausal women's skin.
Topical DHEA increased expression of multiple collagen genes and altered keratinocyte-related genes in postmenopausal women's skin.
Topical DHEA increased expression of multiple collagen genes and altered keratinocyte-related genes in postmenopausal women's skin.
Use of a collagen membrane with bovine bone graft improved periodontal pocket depth and attachment over 12 months compared with flap procedure alone.
Six months of inhaled beclomethasone reduced airway mucosal vascularity and was associated with changes in subepithelial collagen III thickness in asthmatic patients.
Six months of inhaled beclomethasone reduced airway mucosal vascularity and was associated with changes in subepithelial collagen III thickness in asthmatic patients.
Pilot RCT comparing two collagen barrier membranes for guided bone regeneration: both membranes showed graft volume loss and no significant differences between them.
Pilot RCT comparing two collagen barrier membranes for guided bone regeneration: both membranes showed graft volume loss and no significant differences between them.
Pilot RCT comparing two collagen barrier membranes for guided bone regeneration: both membranes showed graft volume loss and no significant differences between them.
Compared alveolar ridge preservation methods after extraction and found that bovine bone mineral with collagen membrane and PRGF reduced horizontal and vertical bone loss versus spontaneous healing.
Compared alveolar ridge preservation methods after extraction and found that bovine bone mineral with collagen membrane and PRGF reduced horizontal and vertical bone loss versus spontaneous healing.
In patients with chronic heart failure and persistent atrial fibrillation, adding omega‑3 PUFA improved arterial elastic properties and reduced a collagen‑matrix marker (TIMP‑1) over 6 months.
In patients with chronic heart failure and persistent atrial fibrillation, adding omega‑3 PUFA improved arterial elastic properties and reduced a collagen‑matrix marker (TIMP‑1) over 6 months.
Daylight photodynamic therapy with pretreatment CO2 laser improved clinical and histologic outcomes for photodamaged facial skin, including a significant increase in collagen type I and reduced solar elastosis.
Both guided bone regeneration approaches produced sufficient horizontal ridge augmentation for implants; mean horizontal bone width gains at 18 months were similar and implant survival was 100% in both groups.
Adding Korean Red Ginseng to antiviral therapy in chronic hepatitis B reduced some non‑invasive fibrosis markers (hyaluronic acid and TGF‑β) compared with antivirals alone.
Adding Korean Red Ginseng to antiviral therapy in chronic hepatitis B reduced some non‑invasive fibrosis markers (hyaluronic acid and TGF‑β) compared with antivirals alone.
Single-session split-face trial found both lasers improved acne scar appearance and increased dermal collagen/elastic fibers by 3 months, with fewer PIH events on picosecond side.
Fractional CO2 laser produced greater scar improvement than hyaluronidase injections (larger volume reduction, better histologic collagen reorganization and markers of remodeling) in early scars.
Fractional CO2 laser produced greater scar improvement than hyaluronidase injections (larger volume reduction, better histologic collagen reorganization and markers of remodeling) in early scars.
Fractional CO2 laser produced greater scar improvement than hyaluronidase injections (larger volume reduction, better histologic collagen reorganization and markers of remodeling) in early scars.
Randomized clinical trial (26 completers) comparing synthetic bone substitute vs bovine-derived xenograft, both covered with a collagen membrane; both preserved ridge height but bucco-lingual width decreased less with the synthetic material.
Randomized clinical trial (26 completers) comparing synthetic bone substitute vs bovine-derived xenograft, both covered with a collagen membrane; both preserved ridge height but bucco-lingual width decreased less with the synthetic material.
Randomized clinical trial (26 completers) comparing synthetic bone substitute vs bovine-derived xenograft, both covered with a collagen membrane; both preserved ridge height but bucco-lingual width decreased less with the synthetic material.
Large randomized study (n=852) comparing collagen-plug closure device, clip device, and wound dressing after femoral artery access; collagen plug had the lowest complication rates.
Large randomized study (n=852) comparing collagen-plug closure device, clip device, and wound dressing after femoral artery access; collagen plug had the lowest complication rates.
In children with new atopic asthma, adding vitamin D to high-dose inhaled corticosteroids improved markers of calcium-phosphorus balance and reduced a urine marker of bone degradation over 6 months.
In children with new atopic asthma, adding vitamin D to high-dose inhaled corticosteroids improved markers of calcium-phosphorus balance and reduced a urine marker of bone degradation over 6 months.
Genetic variants in collagen-family genes were associated with both risk of uterine fibroids and increased tumor size in a large premenopausal cohort.
Genetic variants in collagen-family genes were associated with both risk of uterine fibroids and increased tumor size in a large premenopausal cohort.
Both ACI with a porcine type I/III collagen cover and MACI (collagen bilayer) produced comparable clinical, arthroscopic and histological improvements at one year.
Both ACI with a porcine type I/III collagen cover and MACI (collagen bilayer) produced comparable clinical, arthroscopic and histological improvements at one year.
Both ACI with a porcine type I/III collagen cover and MACI (collagen bilayer) produced comparable clinical, arthroscopic and histological improvements at one year.
In immediate implant placement, connective tissue grafts prevented marginal peri-implant recession and improved soft tissue contour and thickness; a collagen matrix group was included but its effects were not clearly reported in the abstract.
In immediate implant placement, connective tissue grafts prevented marginal peri-implant recession and improved soft tissue contour and thickness; a collagen matrix group was included but its effects were not clearly reported in the abstract.
In hip surgery patients, surgery increased thrombin generation and platelet activation causing reduced aggregation overall; albumin infusion specifically inhibited collagen‑induced platelet aggregation.
In hypertensive patients, quinapril (ACE inhibitor) improved measures of platelet function including parameters of collagen‑induced aggregation and reduced beta‑thromboglobulin, whereas nifedipine did not.
In hip surgery patients, surgery increased thrombin generation and platelet activation causing reduced aggregation overall; albumin infusion specifically inhibited collagen‑induced platelet aggregation.
In hip surgery patients, surgery increased thrombin generation and platelet activation causing reduced aggregation overall; albumin infusion specifically inhibited collagen‑induced platelet aggregation.
After CABG, low‑dose aspirin (50 mg/day) produced sustained inhibition of platelet aggregation induced by collagen and markedly reduced thromboxane B2 synthesis in vitro.
After CABG, low‑dose aspirin (50 mg/day) produced sustained inhibition of platelet aggregation induced by collagen and markedly reduced thromboxane B2 synthesis in vitro.
After CABG, low‑dose aspirin (50 mg/day) produced sustained inhibition of platelet aggregation induced by collagen and markedly reduced thromboxane B2 synthesis in vitro.
In hypertensive patients, quinapril (ACE inhibitor) improved measures of platelet function including parameters of collagen‑induced aggregation and reduced beta‑thromboglobulin, whereas nifedipine did not.
Obese women had lower serum 25-hydroxyvitamin D and higher PTH; low vitamin D was not associated with comorbid conditions except osteoarthritis.
Obese women had lower serum 25-hydroxyvitamin D and higher PTH; low vitamin D was not associated with comorbid conditions except osteoarthritis.
Obese women had lower serum 25-hydroxyvitamin D and higher PTH; low vitamin D was not associated with comorbid conditions except osteoarthritis.
Exploratory RCT: using DBBM-C (xenogenic bone with 10% collagen) ± collagen matrix for ridge preservation increased soft tissue thickness and reduced invaginations and need for augmentation versus spontaneous healing at 8 weeks.
Exploratory RCT: using DBBM-C (xenogenic bone with 10% collagen) ± collagen matrix for ridge preservation increased soft tissue thickness and reduced invaginations and need for augmentation versus spontaneous healing at 8 weeks.
Exploratory RCT: using DBBM-C (xenogenic bone with 10% collagen) ± collagen matrix for ridge preservation increased soft tissue thickness and reduced invaginations and need for augmentation versus spontaneous healing at 8 weeks.
Randomized controlled trial comparing DBBM-C + collagen matrix, DBBM-C + palatal graft, and spontaneous healing: ARP with collagen matrix reduced horizontal/vertical bone loss and reduced need for additional augmentation at 8 weeks.
Randomized controlled trial comparing DBBM-C + collagen matrix, DBBM-C + palatal graft, and spontaneous healing: ARP with collagen matrix reduced horizontal/vertical bone loss and reduced need for additional augmentation at 8 weeks.
Randomized controlled trial comparing DBBM-C + collagen matrix, DBBM-C + palatal graft, and spontaneous healing: ARP with collagen matrix reduced horizontal/vertical bone loss and reduced need for additional augmentation at 8 weeks.
Adding rhBMP-2 delivered on an absorbable collagen sponge did not significantly accelerate fracture healing and showed a non‑significant trend toward higher infection.
Adding rhBMP-2 delivered on an absorbable collagen sponge did not significantly accelerate fracture healing and showed a non‑significant trend toward higher infection.
Randomized trial after hip replacement: added activity increased DNA content in subcutaneous implant but did not improve collagen markers or wound-healing measures.
Randomized trial after hip replacement: added activity increased DNA content in subcutaneous implant but did not improve collagen markers or wound-healing measures.
Randomized trial after hip replacement: added activity increased DNA content in subcutaneous implant but did not improve collagen markers or wound-healing measures.
Prospective randomized trial of a fibrin-glue coated collagen patch vs standard closure after axillary lymphadenectomy found no significant differences in drainage duration, drainage volume, hospital stay, local inflammation, or seroma formation.
Prospective randomized trial of a fibrin-glue coated collagen patch vs standard closure after axillary lymphadenectomy found no significant differences in drainage duration, drainage volume, hospital stay, local inflammation, or seroma formation.
Prospective randomized trial of a fibrin-glue coated collagen patch vs standard closure after axillary lymphadenectomy found no significant differences in drainage duration, drainage volume, hospital stay, local inflammation, or seroma formation.
Randomized clinical study of two graft materials with the same collagen barrier showed 100% implant survival and similar clinical and radiographic outcomes at 1-year post-loading.
Some patients had modest lasting cosmetic improvement and no long-term side effects up to three years after treatment.
Compared autogenous basilic-brachial AVF to collagen-polyester prosthetic graft (Omniflow II) for hemodialysis access; prosthetic graft had quicker use but worse long-term outcomes.
Some patients had modest lasting cosmetic improvement and no long-term side effects up to three years after treatment.
Both grafting approaches using a collagen membrane produced stable clinical and esthetic results with all implants clinically successful at 1 year.
Both grafting approaches using a collagen membrane produced stable clinical and esthetic results with all implants clinically successful at 1 year.
After tooth extraction, using DBBM with a soft tissue punch or adding an absorbable collagen membrane limited bucco-oral tissue loss compared with DBBM alone or no treatment at 6 months.
After tooth extraction, using DBBM with a soft tissue punch or adding an absorbable collagen membrane limited bucco-oral tissue loss compared with DBBM alone or no treatment at 6 months.
After tooth extraction, using DBBM with a soft tissue punch or adding an absorbable collagen membrane limited bucco-oral tissue loss compared with DBBM alone or no treatment at 6 months.
Combination of botulinum toxin type A and full-face broadband light produced better cosmetic improvement than light alone and skin biopsies showed increased dermal collagen.
Both low-dose oral isotretinoin and topical retinoic acid improved photoaging and were associated with increased dermal collagen type I on immunohistochemistry, with no difference between treatments.
12-week randomized double-blind trial of water-soluble eggshell membrane (contains collagen and GAGs) in knee OA found early reduction in stiffness (day 5) and improved individual 6-minute walk performance by day 84, but no between-group difference in overall WOMAC composite scores.
12-week randomized double-blind trial of water-soluble eggshell membrane (contains collagen and GAGs) in knee OA found early reduction in stiffness (day 5) and improved individual 6-minute walk performance by day 84, but no between-group difference in overall WOMAC composite scores.
12-week randomized double-blind trial of water-soluble eggshell membrane (contains collagen and GAGs) in knee OA found early reduction in stiffness (day 5) and improved individual 6-minute walk performance by day 84, but no between-group difference in overall WOMAC composite scores.
Randomized trial comparing woven vs collagen-impregnated knitted Dacron arterial grafts; knitted grafts had lower intraoperative blood loss but otherwise similar performance and patency at 1 year.
Randomized trial comparing woven vs collagen-impregnated knitted Dacron arterial grafts; knitted grafts had lower intraoperative blood loss but otherwise similar performance and patency at 1 year.
Randomized trial comparing DBBM vs DBBM + 10% collagen for alveolar ridge preservation; overall mid-facial mucosal level and long-term tissue stability similar between materials, with some early soft tissue thickness advantage for DBBM alone.
Acellular dermal matrix (ADM) produced more collagen fibers but showed greater tissue shrinkage and delayed healing compared with free gingival grafts.
RCT comparing immediate implants with or without DBBM-C (10% collagen); adding DBBM-C slightly reduced tissue dimensional changes with one significant benefit at the distal papilla.
Randomized trial comparing DBBM vs DBBM + 10% collagen for alveolar ridge preservation; overall mid-facial mucosal level and long-term tissue stability similar between materials, with some early soft tissue thickness advantage for DBBM alone.
In a 15-week randomized double-blind trial, daily 15 g collagen peptide supplementation with resistance training increased muscle hypertrophy and evoked twitch torque but did not augment voluntary strength versus placebo.
In a 15-week randomized double-blind trial, daily 15 g collagen peptide supplementation with resistance training increased muscle hypertrophy and evoked twitch torque but did not augment voluntary strength versus placebo.
In a 15-week randomized double-blind trial, daily 15 g collagen peptide supplementation with resistance training increased muscle hypertrophy and evoked twitch torque but did not augment voluntary strength versus placebo.
In controlled absorption studies in women, purified collagen (and other isolated animal proteins) did not change heme iron bioavailability, whereas red blood cell concentrate increased it and mixing heme with fish or chicken reduced it.
In controlled absorption studies in women, purified collagen (and other isolated animal proteins) did not change heme iron bioavailability, whereas red blood cell concentrate increased it and mixing heme with fish or chicken reduced it.
In controlled absorption studies in women, purified collagen (and other isolated animal proteins) did not change heme iron bioavailability, whereas red blood cell concentrate increased it and mixing heme with fish or chicken reduced it.
In 22 patients, autologous concentrated growth factor (CGF) membranes produced faster soft-tissue healing and higher microvessel density than Bio-Gide collagen membranes, while alveolar bone preservation was similar between groups.
Enzyme (collagenase) injections that break down excess collagen reduced finger contractures and were safe in most patients.
Higher blood markers of collagen turnover were linked to worse walking distance and higher risk of death or hospitalization in chronic heart failure patients.
Long-term alfacalcidol (vitamin D analog) increased bone mineral density at spine and hip and lowered parathyroid hormone and bone turnover markers in pre-dialysis CRF patients.
Immediate implants with or without anorganic bovine bone + resorbable collagen barrier were compared over 3 years; no difference in implant failures but graft+collagen group showed greater marginal bone loss and worse esthetic/patient satisfaction.
Immediate implants with or without anorganic bovine bone + resorbable collagen barrier were compared over 3 years; no difference in implant failures but graft+collagen group showed greater marginal bone loss and worse esthetic/patient satisfaction.
Insertion of Gentacoll (collagen sponge with gentamicin) after mastectomy reduced infections, seromas, drainage volumes and hospital stay versus control.
Insertion of Gentacoll (collagen sponge with gentamicin) after mastectomy reduced infections, seromas, drainage volumes and hospital stay versus control.
Insertion of Gentacoll (collagen sponge with gentamicin) after mastectomy reduced infections, seromas, drainage volumes and hospital stay versus control.
In 50 patients with bilateral progressive keratoconus, continuous and pulsed accelerated corneal collagen cross-linking with supplemental oxygen produced comparable improvements in corneal topography and biomechanics at one year.
In 50 patients with bilateral progressive keratoconus, continuous and pulsed accelerated corneal collagen cross-linking with supplemental oxygen produced comparable improvements in corneal topography and biomechanics at one year.
In 50 patients with bilateral progressive keratoconus, continuous and pulsed accelerated corneal collagen cross-linking with supplemental oxygen produced comparable improvements in corneal topography and biomechanics at one year.
In 50 patients with bilateral progressive keratoconus, continuous and pulsed accelerated corneal collagen cross-linking with supplemental oxygen produced comparable improvements in corneal topography and biomechanics at one year.
A single teriparatide injection caused short-term changes in calcium metabolism and biphasic changes in bone turnover markers; vitamin D metabolites (1,25(OH)2D) rose transiently but Vitamin D was not the intervention.
A single teriparatide injection caused short-term changes in calcium metabolism and biphasic changes in bone turnover markers; vitamin D metabolites (1,25(OH)2D) rose transiently but Vitamin D was not the intervention.
In 50 volunteers with matched 5-mm wounds, autograft and decellularized dermis treatments yielded reduced dermal fibrosis and different remodeling compared with control and collagen-GAG scaffold over 28 days.
In 50 volunteers with matched 5-mm wounds, autograft and decellularized dermis treatments yielded reduced dermal fibrosis and different remodeling compared with control and collagen-GAG scaffold over 28 days.
In 50 volunteers with matched 5-mm wounds, autograft and decellularized dermis treatments yielded reduced dermal fibrosis and different remodeling compared with control and collagen-GAG scaffold over 28 days.
In 74 postmenopausal women, bisphosphonate therapy (clodronate or yearly zoledronate) reduced bone turnover markers and produced differential effects on Wnt inhibitors (transient DKK1 increases with zoledronate; delayed SOST increase with clodronate).
Analysis of 119 ACL-injured patients showed early ACL reconstruction prolonged elevated synovial inflammatory cytokines versus optional/delayed reconstruction over multiple timepoints, while collagen degradation markers did not differ between treatments over 5 years.
Analysis of 119 ACL-injured patients showed early ACL reconstruction prolonged elevated synovial inflammatory cytokines versus optional/delayed reconstruction over multiple timepoints, while collagen degradation markers did not differ between treatments over 5 years.
Randomized comparative study (n=45; 3 groups of 15) testing periodontal dressings: collagen dressing showed greater symptomatic relief and improved clinical wound-healing indices versus light-cure and non-eugenol dressings.
In renal transplant recipients, adding alendronate to calcium and calcitriol increased femoral neck BMD and decreased bone resorption marker NTx versus calcium+calcitriol alone in the short term.
RCT comparing immediate implants with or without DBBM-C (10% collagen); adding DBBM-C slightly reduced tissue dimensional changes with one significant benefit at the distal papilla.
Randomized double-blind vehicle-controlled 12-week trial of a topical firming/toning lotion (FTB) in 54 women showed significant improvements in skin firmness, texture, and cellulite and preclinical evidence of increased collagen and elastic fiber formation.
Randomized double-blind vehicle-controlled 12-week trial of a topical firming/toning lotion (FTB) in 54 women showed significant improvements in skin firmness, texture, and cellulite and preclinical evidence of increased collagen and elastic fiber formation.
31 renal-allograft recipients randomized to cyclosporine reduction with or without rapamycin; rapamycin group had a fall in GFR and increases in collagen III expression and TIMP-2 without histological improvement in interstitial fibrosis.
31 renal-allograft recipients randomized to cyclosporine reduction with or without rapamycin; rapamycin group had a fall in GFR and increases in collagen III expression and TIMP-2 without histological improvement in interstitial fibrosis.
In human volunteers undergoing 35–90 days of simulated microgravity with or without resistance exercise, quadriceps muscle volume changed but major contractile and connective proteins in the vastus lateralis (including collagen) were preserved.
In human volunteers undergoing 35–90 days of simulated microgravity with or without resistance exercise, quadriceps muscle volume changed but major contractile and connective proteins in the vastus lateralis (including collagen) were preserved.
In human volunteers undergoing 35–90 days of simulated microgravity with or without resistance exercise, quadriceps muscle volume changed but major contractile and connective proteins in the vastus lateralis (including collagen) were preserved.
In vitro and two randomized healthy-volunteer trials showed near-complete Lp-PLA2 inhibition but no clinically relevant enhancement of platelet aggregation to collagen, ADP, or PAF.
In vitro and two randomized healthy-volunteer trials showed near-complete Lp-PLA2 inhibition but no clinically relevant enhancement of platelet aggregation to collagen, ADP, or PAF.
In cardiac reoperations, harvesting and reinfusing autologous platelet concentrate reduced bleeding and increased platelet counts and collagen-induced whole blood platelet aggregation compared with autologous whole blood.
In cardiac reoperations, harvesting and reinfusing autologous platelet concentrate reduced bleeding and increased platelet counts and collagen-induced whole blood platelet aggregation compared with autologous whole blood.
In cardiac reoperations, harvesting and reinfusing autologous platelet concentrate reduced bleeding and increased platelet counts and collagen-induced whole blood platelet aggregation compared with autologous whole blood.
In postmenopausal breast cancer patients, tamoxifen reduced markers of bone resorption and formation and increased spine and femoral BMD, whereas toremifene showed smaller effects.
In a 14-day randomized trial, transnasal budesonide reduced polyp size and eosinophilic inflammation but increased collagen deposition and TIMP levels in nasal polyps versus placebo.
In a 14-day randomized trial, transnasal budesonide reduced polyp size and eosinophilic inflammation but increased collagen deposition and TIMP levels in nasal polyps versus placebo.
In a 14-day randomized trial, transnasal budesonide reduced polyp size and eosinophilic inflammation but increased collagen deposition and TIMP levels in nasal polyps versus placebo.
DBBM with 10% collagen (DBBM-C) was non-inferior to DBBM alone for maintaining alveolar ridge width 4 months after extraction.
DBBM with 10% collagen (DBBM-C) was non-inferior to DBBM alone for maintaining alveolar ridge width 4 months after extraction.
DBBM with 10% collagen (DBBM-C) was non-inferior to DBBM alone for maintaining alveolar ridge width 4 months after extraction.
Injection of autologous skin-derived collagen-producing fibroblasts improved pain and function in refractory Achilles tendinosis at six months.
In mild-moderate heart failure, spironolactone lowered BNP and a blood marker of collagen turnover (PIIINP) but worsened renal function and self-reported quality of life over 3 months.
In mild-moderate heart failure, spironolactone lowered BNP and a blood marker of collagen turnover (PIIINP) but worsened renal function and self-reported quality of life over 3 months.
ONO-5334 produced dose-dependent, large reductions in a bone collagen resorption marker (urinary C-terminal telopeptide of type I collagen) with minimal effects on bone-formation markers.
ONO-5334 produced dose-dependent, large reductions in a bone collagen resorption marker (urinary C-terminal telopeptide of type I collagen) with minimal effects on bone-formation markers.
ONO-5334 produced dose-dependent, large reductions in a bone collagen resorption marker (urinary C-terminal telopeptide of type I collagen) with minimal effects on bone-formation markers.
Randomized trial comparing LigaSure (creates a collagen seal) versus conventional clips/ties in thyroidectomy; no change in operative time, improved postoperative VHI with LigaSure, but substantially higher device cost.
Using rhBMP-2 on an absorbable collagen sponge with interbody cages yielded higher fusion rates and less operative time and blood loss than autograft, avoiding donor-site morbidity.
In healthy postmenopausal women (three dosing cohorts totaling 81), a single 0.8 mg oral salmon calcitonin dose significantly suppressed serum CTX (a collagen type I degradation marker), with pre-dinner dosing producing the largest overall suppression.
In healthy postmenopausal women (three dosing cohorts totaling 81), a single 0.8 mg oral salmon calcitonin dose significantly suppressed serum CTX (a collagen type I degradation marker), with pre-dinner dosing producing the largest overall suppression.
In healthy postmenopausal women (three dosing cohorts totaling 81), a single 0.8 mg oral salmon calcitonin dose significantly suppressed serum CTX (a collagen type I degradation marker), with pre-dinner dosing producing the largest overall suppression.
Plasma gel injections, alone or combined with microneedling, improved atrophic acne scars and increased collagen and elastic fiber formation on histology.
Plasma gel injections, alone or combined with microneedling, improved atrophic acne scars and increased collagen and elastic fiber formation on histology.
Plasma gel injections, alone or combined with microneedling, improved atrophic acne scars and increased collagen and elastic fiber formation on histology.
A multimodal scar prevention program (including occlusive tape with active agents targeting hydration, inflammation, and collagen maturation) improved scar outcomes at 6 months across treated groups.
A multimodal scar prevention program (including occlusive tape with active agents targeting hydration, inflammation, and collagen maturation) improved scar outcomes at 6 months across treated groups.
A multimodal scar prevention program (including occlusive tape with active agents targeting hydration, inflammation, and collagen maturation) improved scar outcomes at 6 months across treated groups.
In 200 CRF patients randomized to autologous MSCs vs N-acetylcysteine, MSCs produced greater improvements in renal function markers and oxidative stress over 8 weeks.
In 86 immediate-implant sites, placing DBBM-C (contains 10% collagen) in the implant-bone gap reduced horizontal buccal bone loss at 16 weeks compared with no graft.
In 86 immediate-implant sites, placing DBBM-C (contains 10% collagen) in the implant-bone gap reduced horizontal buccal bone loss at 16 weeks compared with no graft.
Use of a collagen-containing hemostatic sealant (TachoSil) at the staple line reduced postoperative blood loss compared with no sealant.
Use of a collagen-containing hemostatic sealant (TachoSil) at the staple line reduced postoperative blood loss compared with no sealant.
Use of a collagen-containing hemostatic sealant (TachoSil) at the staple line reduced postoperative blood loss compared with no sealant.
Both techniques (non-resorbable membrane vs titanium mesh + collagen membrane) produced ~30% newly formed bone by micro-CT with no significant differences between groups.
Both techniques (non-resorbable membrane vs titanium mesh + collagen membrane) produced ~30% newly formed bone by micro-CT with no significant differences between groups.
Eight weeks of split-face home device use improved skin-aging measures and increased type I collagen expression while decreasing MMP-1, with no adverse effects.
In 33 children, adding Ologen (a collagen matrix) to Ahmed valve implantation lowered intraocular pressure more than valve alone over follow-up without added safety issues.
In 33 children, adding Ologen (a collagen matrix) to Ahmed valve implantation lowered intraocular pressure more than valve alone over follow-up without added safety issues.
Two single-center 28-day topical lotion studies (5% and 20% TBFE) in adults showed improved skin tone, reduced water loss, increased hydration and reduced wrinkles.
Two single-center 28-day topical lotion studies (5% and 20% TBFE) in adults showed improved skin tone, reduced water loss, increased hydration and reduced wrinkles.
Randomized trial (n=126) testing dissolvable punctal plugs after intravitreal injection prep with PVI found no overall reduction in ocular surface symptoms, but benefit in subgroup with objective dry eye.
Randomized trial (n=126) testing dissolvable punctal plugs after intravitreal injection prep with PVI found no overall reduction in ocular surface symptoms, but benefit in subgroup with objective dry eye.
Randomized trial (n=126) testing dissolvable punctal plugs after intravitreal injection prep with PVI found no overall reduction in ocular surface symptoms, but benefit in subgroup with objective dry eye.
In 64 patients, equine-derived collagenated xenogeneic bone blocks were non-inferior to autogenous bone blocks for horizontal ridge augmentation, with less early post-op pain.
In 64 patients, equine-derived collagenated xenogeneic bone blocks were non-inferior to autogenous bone blocks for horizontal ridge augmentation, with less early post-op pain.
In 833 glucocorticoid-treated patients, annual zoledronic acid reduced bone turnover markers more than daily risedronate over 12 months.
In 833 glucocorticoid-treated patients, annual zoledronic acid reduced bone turnover markers more than daily risedronate over 12 months.
PTH therapy increased early collagen-formation markers and larger short-term increases predicted greater spine and hip BMD gains at 1 year.
Single-session split-face trial found both lasers improved acne scar appearance and increased dermal collagen/elastic fibers by 3 months, with fewer PIH events on picosecond side.
Single-session split-face trial found both lasers improved acne scar appearance and increased dermal collagen/elastic fibers by 3 months, with fewer PIH events on picosecond side.
Randomized paired trial comparing intralesional verapamil (a calcium-channel blocker) versus triamcinolone for keloids; steroids improved scars, verapamil showed no significant benefit.
Randomized paired trial comparing intralesional verapamil (a calcium-channel blocker) versus triamcinolone for keloids; steroids improved scars, verapamil showed no significant benefit.
Randomized paired trial comparing intralesional verapamil (a calcium-channel blocker) versus triamcinolone for keloids; steroids improved scars, verapamil showed no significant benefit.
Injections for nasolabial folds showed PLLA (not CaHA) upregulated adipocyte-regeneration genes, suggesting a unique adipocyte-mediated regenerative signature absent with calcium hydroxylapatite.
Injections for nasolabial folds showed PLLA (not CaHA) upregulated adipocyte-regeneration genes, suggesting a unique adipocyte-mediated regenerative signature absent with calcium hydroxylapatite.
Injections for nasolabial folds showed PLLA (not CaHA) upregulated adipocyte-regeneration genes, suggesting a unique adipocyte-mediated regenerative signature absent with calcium hydroxylapatite.
In 52 postmenopausal osteoporotic women on alendronate, twice-weekly WBV improved flexibility, balance, and walking speed, while collagen turnover markers changed similarly in both groups.
In 52 postmenopausal osteoporotic women on alendronate, twice-weekly WBV improved flexibility, balance, and walking speed, while collagen turnover markers changed similarly in both groups.
In 52 postmenopausal osteoporotic women on alendronate, twice-weekly WBV improved flexibility, balance, and walking speed, while collagen turnover markers changed similarly in both groups.
In 372 adults, autologous fibroblast injections significantly improved nasolabial fold wrinkles versus placebo with mostly mild adverse events.
In 372 adults, autologous fibroblast injections significantly improved nasolabial fold wrinkles versus placebo with mostly mild adverse events.
Randomized trial: topical recombinant human EGF accelerated healing of diabetic foot ulcers, with greater collagen/fibroblast development in treated wounds.
Randomized trial: topical recombinant human EGF accelerated healing of diabetic foot ulcers, with greater collagen/fibroblast development in treated wounds.
Simvastatin reduced plaque inflammation and MMP activity and increased plaque collagen content, consistent with plaque stabilization.
Simvastatin reduced plaque inflammation and MMP activity and increased plaque collagen content, consistent with plaque stabilization.
Adding clopidogrel to aspirin significantly reduced multiple measures of platelet activation versus aspirin alone in heart failure patients with heightened platelet activity.
Adding clopidogrel to aspirin significantly reduced multiple measures of platelet activation versus aspirin alone in heart failure patients with heightened platelet activity.
Three years of combined GH and GnRHa slowed bone maturation and increased predicted adult height, while collagen propeptide markers did not change.
Three years of combined GH and GnRHa slowed bone maturation and increased predicted adult height, while collagen propeptide markers did not change.
Three years of combined GH and GnRHa slowed bone maturation and increased predicted adult height, while collagen propeptide markers did not change.
Indobufen and aspirin similarly suppressed thromboxane production and platelet aggregation but indobufen spared prostacyclin production relative to aspirin.
Indobufen and aspirin similarly suppressed thromboxane production and platelet aggregation but indobufen spared prostacyclin production relative to aspirin.
Indobufen and aspirin similarly suppressed thromboxane production and platelet aggregation but indobufen spared prostacyclin production relative to aspirin.
Low-dose cyclical gallium nitrate reduced serum alkaline phosphatase and urinary markers of collagen turnover at higher doses in Paget's disease.
Low-dose cyclical gallium nitrate reduced serum alkaline phosphatase and urinary markers of collagen turnover at higher doses in Paget's disease.
Randomized trial of equine-derived collagenated xenogeneic bone block (CXBB) versus autogenous bone block (ABB) for lateral ridge augmentation; 1-year implant survival and clinical/aesthetic outcomes showed no statistically significant differences.
Randomized trial of equine-derived collagenated xenogeneic bone block (CXBB) versus autogenous bone block (ABB) for lateral ridge augmentation; 1-year implant survival and clinical/aesthetic outcomes showed no statistically significant differences.
Multicenter randomized study of two bovine bone xenografts for socket preservation; all sites covered with a resorbable collagen membrane for 6 months, with similar histologic bone formation between groups.
Multicenter randomized study of two bovine bone xenografts for socket preservation; all sites covered with a resorbable collagen membrane for 6 months, with similar histologic bone formation between groups.
Using deproteinised bovine bone mineral plus a resorbable collagen membrane after impacted third molar extraction improved alveolar bone dimensions and periodontal status versus natural healing.
Using deproteinised bovine bone mineral plus a resorbable collagen membrane after impacted third molar extraction improved alveolar bone dimensions and periodontal status versus natural healing.
Guided bone regeneration using particulate bone graft and a resorbable collagen membrane resulted in horizontal ridge width reduction during 6 months of healing; vertical level influenced reduction more than healing strategy.
Guided bone regeneration using particulate bone graft and a resorbable collagen membrane resulted in horizontal ridge width reduction during 6 months of healing; vertical level influenced reduction more than healing strategy.
In this randomized trial, covering customized titanium mesh with a resorbable collagen membrane produced a small, non-significant increase in percentage of bone and a trend toward less residual graft material compared with mesh alone at 6 months.
In this randomized trial, covering customized titanium mesh with a resorbable collagen membrane produced a small, non-significant increase in percentage of bone and a trend toward less residual graft material compared with mesh alone at 6 months.
In this randomized trial, covering customized titanium mesh with a resorbable collagen membrane produced a small, non-significant increase in percentage of bone and a trend toward less residual graft material compared with mesh alone at 6 months.
Compared autogenous basilic-brachial AVF to collagen-polyester prosthetic graft (Omniflow II) for hemodialysis access; prosthetic graft had quicker use but worse long-term outcomes.
Compared autogenous basilic-brachial AVF to collagen-polyester prosthetic graft (Omniflow II) for hemodialysis access; prosthetic graft had quicker use but worse long-term outcomes.
Examined scalp hair from patients receiving PUVA or narrowband UVB and found greater hair damage and disorganized perifollicular collagen after UV exposure, especially PUVA.
Examined scalp hair from patients receiving PUVA or narrowband UVB and found greater hair damage and disorganized perifollicular collagen after UV exposure, especially PUVA.
Examined scalp hair from patients receiving PUVA or narrowband UVB and found greater hair damage and disorganized perifollicular collagen after UV exposure, especially PUVA.
Oral clodronate for 2 years lowered type I collagen turnover biomarkers but did not change radiographic joint damage progression.
Oral clodronate for 2 years lowered type I collagen turnover biomarkers but did not change radiographic joint damage progression.
Oral clodronate for 2 years lowered type I collagen turnover biomarkers but did not change radiographic joint damage progression.
Adding a gentamicin–collagen sponge to primary excision reduced early (1-week) postoperative complications but did not change long-term recurrence.
Adding a gentamicin–collagen sponge to primary excision reduced early (1-week) postoperative complications but did not change long-term recurrence.
Randomized trial of a collagen-based arterial closure device showing faster hemostasis and earlier discharge with similar complication rates.
Randomized trial of a collagen-based arterial closure device showing faster hemostasis and earlier discharge with similar complication rates.
A collagen-containing powder (CP) achieved hemostasis more often and faster preparation than a control hemostatic matrix in cardiothoracic surgery.
A collagen-containing powder (CP) achieved hemostasis more often and faster preparation than a control hemostatic matrix in cardiothoracic surgery.
A collagen-containing powder (CP) achieved hemostasis more often and faster preparation than a control hemostatic matrix in cardiothoracic surgery.
Topical cyclized collagen-derived peptide (CHP-9) applied twice daily for 56 days improved wrinkles, elasticity, pigmentation, hydration and barrier function and outperformed low-dose retinol and vehicle without reported adverse events.
Topical cyclized collagen-derived peptide (CHP-9) applied twice daily for 56 days improved wrinkles, elasticity, pigmentation, hydration and barrier function and outperformed low-dose retinol and vehicle without reported adverse events.
Topical cyclized collagen-derived peptide (CHP-9) applied twice daily for 56 days improved wrinkles, elasticity, pigmentation, hydration and barrier function and outperformed low-dose retinol and vehicle without reported adverse events.
Compared tendon and muscle stretch during walking in long-term diabetes patients versus controls; tendon length changes were reduced in diabetes and related to diabetes duration.
Compared tendon and muscle stretch during walking in long-term diabetes patients versus controls; tendon length changes were reduced in diabetes and related to diabetes duration.
Compared tendon and muscle stretch during walking in long-term diabetes patients versus controls; tendon length changes were reduced in diabetes and related to diabetes duration.
Randomized trial in anticoagulated patients undergoing simple dental extractions; local hemostasis with resorbable collagen sponges was used in the group maintaining oral anticoagulation.
Randomized trial in anticoagulated patients undergoing simple dental extractions; local hemostasis with resorbable collagen sponges was used in the group maintaining oral anticoagulation.
Randomized trial in anticoagulated patients undergoing simple dental extractions; local hemostasis with resorbable collagen sponges was used in the group maintaining oral anticoagulation.
Examined how heparinization and storage conditions affect platelet aggregation responses to collagen in patients undergoing coronary bypass; platelet macroaggregation to collagen was depressed after heparin and by storage.
Examined how heparinization and storage conditions affect platelet aggregation responses to collagen in patients undergoing coronary bypass; platelet macroaggregation to collagen was depressed after heparin and by storage.
Double-blind RCT: a multi-ingredient supplement (included 300 mg calcium citrate) plus resistance training increased lean body mass and some upper-body muscle size measures more than an isonitrogenous placebo.
Randomized trial of two whole-body vibration frequencies (20 Hz vs 30 Hz) in chronic stroke patients; both increased knee strength and reduced bone resorption (NTx), with 30 Hz showing greater paretic eccentric strength gains.
Randomized trial of two whole-body vibration frequencies (20 Hz vs 30 Hz) in chronic stroke patients; both increased knee strength and reduced bone resorption (NTx), with 30 Hz showing greater paretic eccentric strength gains.
Compared thumb trapeziectomy using patient's tendon versus a human dermal collagen allograft; both improved hand outcome scores similarly but the allograft group had more complications.
Compared thumb trapeziectomy using patient's tendon versus a human dermal collagen allograft; both improved hand outcome scores similarly but the allograft group had more complications.
Compared thumb trapeziectomy using patient's tendon versus a human dermal collagen allograft; both improved hand outcome scores similarly but the allograft group had more complications.
Weekly IV BMS-986263 (HSP47 siRNA LNP) for 12 weeks produced target engagement and fibrosis improvement in some patients with advanced hepatic fibrosis and was generally well tolerated.
Weekly IV BMS-986263 (HSP47 siRNA LNP) for 12 weeks produced target engagement and fibrosis improvement in some patients with advanced hepatic fibrosis and was generally well tolerated.
Weekly IV BMS-986263 (HSP47 siRNA LNP) for 12 weeks produced target engagement and fibrosis improvement in some patients with advanced hepatic fibrosis and was generally well tolerated.
RCT comparing ADM with vs without basement membrane in immediate prepectoral breast reconstruction: no significant differences in overall complications or shape change; seromas more frequent with basement membrane (10% vs 0%).
RCT comparing ADM with vs without basement membrane in immediate prepectoral breast reconstruction: no significant differences in overall complications or shape change; seromas more frequent with basement membrane (10% vs 0%).
In >1,100 HFpEF patients sacubitril/valsartan (vs valsartan) favorably altered circulating extracellular matrix/collagen-related biomarkers at 16 weeks.
In >1,100 HFpEF patients sacubitril/valsartan (vs valsartan) favorably altered circulating extracellular matrix/collagen-related biomarkers at 16 weeks.
Adding Clostridium butyricum to rosuvastatin in NAFLD patients improved gut microbiota composition and reduced lipids, liver enzymes, fibrosis markers and inflammatory cytokines compared with rosuvastatin alone.
Adding Clostridium butyricum to rosuvastatin in NAFLD patients improved gut microbiota composition and reduced lipids, liver enzymes, fibrosis markers and inflammatory cytokines compared with rosuvastatin alone.
Randomized double-blind 30-day trial (67 completers) found Aflapin reduced knee pain and improved function; collagen type II cleavage biomarker (C2C) and inflammatory biomarkers decreased.
A 12-week study in women with photodamaged skin showing improved skin hydration and increased HA and collagen gene expression after topical serum use.
A 12-week study in women with photodamaged skin showing improved skin hydration and increased HA and collagen gene expression after topical serum use.
A 12-week study in women with photodamaged skin showing improved skin hydration and increased HA and collagen gene expression after topical serum use.
Randomized trial comparing AMIC (uses a type I/III collagen membrane) versus microfracture for knee cartilage lesions; AMIC showed sustained clinical benefit at 5 years.
Randomized trial comparing AMIC (uses a type I/III collagen membrane) versus microfracture for knee cartilage lesions; AMIC showed sustained clinical benefit at 5 years.
Prospective randomized trial comparing donor-site dressings including an equine collagen foil; collagen foil showed similar healing time and scarring to other dressings.
Prospective randomized trial comparing donor-site dressings including an equine collagen foil; collagen foil showed similar healing time and scarring to other dressings.
Adding collagenase to trypsin during hair follicle cell suspension preparation increased pigment-cell retrieval and led to greater repigmentation of vitiligo patches over 6 months.
Adding collagenase to trypsin during hair follicle cell suspension preparation increased pigment-cell retrieval and led to greater repigmentation of vitiligo patches over 6 months.
Adding collagenase to trypsin during hair follicle cell suspension preparation increased pigment-cell retrieval and led to greater repigmentation of vitiligo patches over 6 months.
In 22 patients, autologous concentrated growth factor (CGF) membranes produced faster soft-tissue healing and higher microvessel density than Bio-Gide collagen membranes, while alveolar bone preservation was similar between groups.
In 22 patients, autologous concentrated growth factor (CGF) membranes produced faster soft-tissue healing and higher microvessel density than Bio-Gide collagen membranes, while alveolar bone preservation was similar between groups.
Study of postmenopausal RA patients (both groups received vitamin D3 and calcium) found resistin associated with markers of inflammation and reduced BMD; HRT transiently increased resistin in year 1.
Study of postmenopausal RA patients (both groups received vitamin D3 and calcium) found resistin associated with markers of inflammation and reduced BMD; HRT transiently increased resistin in year 1.
In 30 patients, ridge preservation using deproteinized bovine bone mineral plus a collagen matrix reduced coronal horizontal bone loss vs spontaneous healing; immediate implant placement did not add further benefit.
In 30 patients, ridge preservation using deproteinized bovine bone mineral plus a collagen matrix reduced coronal horizontal bone loss vs spontaneous healing; immediate implant placement did not add further benefit.
In 30 patients, ridge preservation using deproteinized bovine bone mineral plus a collagen matrix reduced coronal horizontal bone loss vs spontaneous healing; immediate implant placement did not add further benefit.
One-year randomized trial including a daily bovine collagen supplement arm; assessed muscle protein synthesis and muscle metabolome.
One-year randomized trial including a daily bovine collagen supplement arm; assessed muscle protein synthesis and muscle metabolome.
In people with relapsing-remitting MS, weekly high-dose vitamin D raised vitamin D levels but did not meaningfully change common blood markers of bone formation or resorption over 96 weeks.
In 96 KOA patients, acupuncture±moxibustion improved symptoms and reduced markers of cartilage turnover and MMP/TIMP imbalance.
In 96 KOA patients, acupuncture±moxibustion improved symptoms and reduced markers of cartilage turnover and MMP/TIMP imbalance.
In 96 KOA patients, acupuncture±moxibustion improved symptoms and reduced markers of cartilage turnover and MMP/TIMP imbalance.
In a large NAFLD biopsy cohort, automated dual‑photon measurements of collagen-related features accurately quantified fibrosis stage and predicted outcomes.
In a large NAFLD biopsy cohort, automated dual‑photon measurements of collagen-related features accurately quantified fibrosis stage and predicted outcomes.
In a large NAFLD biopsy cohort, automated dual‑photon measurements of collagen-related features accurately quantified fibrosis stage and predicted outcomes.
In a small double‑blind RCT, multispectral LED treatment did not show overall superiority vs sham for grade‑2 sacral pressure ulcers; LED increased epidermal thickness and basement membrane measures but wound area changes were similar.
In 31 postmenopausal women, RF and hybrid fractional laser produced subjective improvements in vulvovaginal symptoms and sexual function domains; biopsies showed decreased expression of collagen I and other ECM genes.
In 31 postmenopausal women, RF and hybrid fractional laser produced subjective improvements in vulvovaginal symptoms and sexual function domains; biopsies showed decreased expression of collagen I and other ECM genes.
In 31 postmenopausal women, RF and hybrid fractional laser produced subjective improvements in vulvovaginal symptoms and sexual function domains; biopsies showed decreased expression of collagen I and other ECM genes.
Sixty patients receiving either gelatin-sealed (Gelseal) or collagen-sealed (Hemashield) aortic grafts: gelatin group showed higher leukocyte counts in the second week, differences resolved by day 21.
Sixty patients receiving either gelatin-sealed (Gelseal) or collagen-sealed (Hemashield) aortic grafts: gelatin group showed higher leukocyte counts in the second week, differences resolved by day 21.
Randomized multicenter trial comparing collagen-coated polypropylene mesh versus anterior colporrhaphy for anterior vaginal wall prolapse; mesh had higher 1-year anatomical success but some mesh-related morbidity.
Randomized multicenter trial comparing collagen-coated polypropylene mesh versus anterior colporrhaphy for anterior vaginal wall prolapse; mesh had higher 1-year anatomical success but some mesh-related morbidity.
Randomized multicenter trial comparing collagen-coated polypropylene mesh versus anterior colporrhaphy for anterior vaginal wall prolapse; mesh had higher 1-year anatomical success but some mesh-related morbidity.
Randomized trial comparing LigaSure (creates a collagen seal) versus conventional clips/ties in thyroidectomy; no change in operative time, improved postoperative VHI with LigaSure, but substantially higher device cost.
Randomized trial comparing LigaSure (creates a collagen seal) versus conventional clips/ties in thyroidectomy; no change in operative time, improved postoperative VHI with LigaSure, but substantially higher device cost.
Randomized allocation of 30 defects in 25 patients to graft alone, graft+PRP, and graft+PRP+membrane; all treatments improved clinical measures similarly with no added clinical benefit from PRP.
Randomized allocation of 30 defects in 25 patients to graft alone, graft+PRP, and graft+PRP+membrane; all treatments improved clinical measures similarly with no added clinical benefit from PRP.
Multicenter randomized trial of an absorbable fibrin sealant patch (collagen sponge coated with fibrin) versus standard treatment after pulmonary resection; AFSP reduced intraoperative leak intensity and postoperative leak duration and was well tolerated.
Multicenter randomized trial of an absorbable fibrin sealant patch (collagen sponge coated with fibrin) versus standard treatment after pulmonary resection; AFSP reduced intraoperative leak intensity and postoperative leak duration and was well tolerated.
Multicenter randomized trial of an absorbable fibrin sealant patch (collagen sponge coated with fibrin) versus standard treatment after pulmonary resection; AFSP reduced intraoperative leak intensity and postoperative leak duration and was well tolerated.
Randomized substudy comparing tamoxifen, exemestane, and anastrozole over 2 years; tamoxifen was associated with lower bone turnover markers (NTX and BAP) versus the two aromatase inhibitors, with BMD trends favoring tamoxifen though not always significant.
Randomized study of Qianggan Capsule with or without lamivudine in chronic hepatitis B patients showed marked decreases in serum fibrosis markers (hyaluronic acid, collagen N, laminin) and higher inflammation improvement with combination therapy; fibrosis improvement rates were similar between groups.
Randomized study of Qianggan Capsule with or without lamivudine in chronic hepatitis B patients showed marked decreases in serum fibrosis markers (hyaluronic acid, collagen N, laminin) and higher inflammation improvement with combination therapy; fibrosis improvement rates were similar between groups.
Randomized study of Qianggan Capsule with or without lamivudine in chronic hepatitis B patients showed marked decreases in serum fibrosis markers (hyaluronic acid, collagen N, laminin) and higher inflammation improvement with combination therapy; fibrosis improvement rates were similar between groups.
Reinforcing anterior colporrhaphy with a bovine pericardium (collagen) graft did not result in a statistically significant improvement in anterior vaginal wall support at 1- or 2-year follow-up.
Reinforcing anterior colporrhaphy with a bovine pericardium (collagen) graft did not result in a statistically significant improvement in anterior vaginal wall support at 1- or 2-year follow-up.
Randomized trial comparing lightweight titanium-coated mesh versus medium-weight collagen-polyester composite mesh found less short-term pain and faster return to activities with the lightweight mesh; recurrence similar at 2 years.
Randomized trial comparing lightweight titanium-coated mesh versus medium-weight collagen-polyester composite mesh found less short-term pain and faster return to activities with the lightweight mesh; recurrence similar at 2 years.
Randomized trial comparing lightweight titanium-coated mesh versus medium-weight collagen-polyester composite mesh found less short-term pain and faster return to activities with the lightweight mesh; recurrence similar at 2 years.
In children with partial-thickness burns, collagenase ointment and silver sulfadiazine produced similar clinical outcomes and need for grafting; collagenase had more wound infections (trend) and higher product cost.
In children with partial-thickness burns, collagenase ointment and silver sulfadiazine produced similar clinical outcomes and need for grafting; collagenase had more wound infections (trend) and higher product cost.
Pilot randomized trial in COPD patients showed that adding a collagen patch (TachoSil) during upper lobectomy reduced postoperative air-leak, chest-drain duration, and hospital stay versus standard stapling.
Pilot randomized trial in COPD patients showed that adding a collagen patch (TachoSil) during upper lobectomy reduced postoperative air-leak, chest-drain duration, and hospital stay versus standard stapling.
Pilot randomized trial in COPD patients showed that adding a collagen patch (TachoSil) during upper lobectomy reduced postoperative air-leak, chest-drain duration, and hospital stay versus standard stapling.
Three lateral sinus-elevation procedures (including use of a collagen membrane) produced similar new bone formation by micro-CT at 7 months.
Three lateral sinus-elevation procedures (including use of a collagen membrane) produced similar new bone formation by micro-CT at 7 months.
Three lateral sinus-elevation procedures (including use of a collagen membrane) produced similar new bone formation by micro-CT at 7 months.
Injection of autologous skin-derived collagen-producing fibroblasts improved pain and function in refractory Achilles tendinosis at six months.
In hemodialysis patients with SHPT, both vitamin D analogs lowered PTH similarly; 22-oxacalcitriol also decreased several bone metabolic markers including collagen-related markers.
In hemodialysis patients with SHPT, both vitamin D analogs lowered PTH similarly; 22-oxacalcitriol also decreased several bone metabolic markers including collagen-related markers.
In hemodialysis patients with SHPT, both vitamin D analogs lowered PTH similarly; 22-oxacalcitriol also decreased several bone metabolic markers including collagen-related markers.
Randomized trial in ischemic foot wounds showed a collagen-based tissue-engineered skin graft substantially improved and accelerated wound healing versus moist dressings.
Randomized trial in ischemic foot wounds showed a collagen-based tissue-engineered skin graft substantially improved and accelerated wound healing versus moist dressings.
LED photobiomodulation (with or without dermocosmetic) reduced abdominal fat measurements and increased collagen/fibroblast deposition in treated abdominal tissue.
LED photobiomodulation (with or without dermocosmetic) reduced abdominal fat measurements and increased collagen/fibroblast deposition in treated abdominal tissue.
LED photobiomodulation (with or without dermocosmetic) reduced abdominal fat measurements and increased collagen/fibroblast deposition in treated abdominal tissue.
Topical PRP gel after pilonidal sinus surgery markedly shortened wound-healing time and time to return to activities, and reduced pain and antibiotic use.
Topical PRP gel after pilonidal sinus surgery markedly shortened wound-healing time and time to return to activities, and reduced pain and antibiotic use.
Topical PRP gel after pilonidal sinus surgery markedly shortened wound-healing time and time to return to activities, and reduced pain and antibiotic use.
Among 639 postmenopausal Chinese women, a GGPPS SNP (rs10925503) was associated with baseline serum β-CTX (a collagen breakdown marker) but GGPPS polymorphisms did not affect bone mineral density or biochemical response to alendronate.
Among 639 postmenopausal Chinese women, a GGPPS SNP (rs10925503) was associated with baseline serum β-CTX (a collagen breakdown marker) but GGPPS polymorphisms did not affect bone mineral density or biochemical response to alendronate.
IV zoledronic acid after ACDF shortened time to osteogenesis, promoted fusion, lowered a collagen degradation marker (CTX) and increased lumbar spine BMD, with improved neck disability scores.
Adding i-PRF to autogenous demineralized dentin graft did not change alveolar ridge width loss but reduced patient-reported pain and better preserved keratinized tissue at 6 months.
Eight weeks of split-face home device use improved skin-aging measures and increased type I collagen expression while decreasing MMP-1, with no adverse effects.
12-week randomized dietary supplement trial in adults with abdominal obesity; whey protein increased urinary calcium but did not change bone turnover markers or BMD.
Salmeterol improved clinical asthma measures but did not change airway inflammation or collagen deposition in biopsies after 6 weeks.
Salmeterol improved clinical asthma measures but did not change airway inflammation or collagen deposition in biopsies after 6 weeks.
Salmeterol improved clinical asthma measures but did not change airway inflammation or collagen deposition in biopsies after 6 weeks.
Adults with GH deficiency had reduced BMD in some subgroups; GH replacement increased bone turnover over 12 months.
Using a collagen-based closure device immediately after PTCA was effective and safe; shortening deployment time from 30 to 5 minutes did not increase complications.
Using a collagen-based closure device immediately after PTCA was effective and safe; shortening deployment time from 30 to 5 minutes did not increase complications.
Using a collagen-based closure device immediately after PTCA was effective and safe; shortening deployment time from 30 to 5 minutes did not increase complications.
Propranolol reduced an osteoblast marker (osteocalcin) and modestly reduced a bone resorption marker (urinary deoxypyridinoline) without changing bone density over 3 months.
Propranolol reduced an osteoblast marker (osteocalcin) and modestly reduced a bone resorption marker (urinary deoxypyridinoline) without changing bone density over 3 months.
Propranolol reduced an osteoblast marker (osteocalcin) and modestly reduced a bone resorption marker (urinary deoxypyridinoline) without changing bone density over 3 months.
A 24-week randomized phase 2 trial (n=72) found selonsertib-treated patients had higher rates of fibrosis improvement and reductions in hepatic collagen content versus simtuzumab alone.
A 24-week randomized phase 2 trial (n=72) found selonsertib-treated patients had higher rates of fibrosis improvement and reductions in hepatic collagen content versus simtuzumab alone.
Among older adults at risk for heart failure, diabetes was associated with altered collagen biomarkers and diastolic function; spironolactone had modest short-term effects on collagen turnover markers but no major differential long-term effects by diabetes/CAD status.
Among older adults at risk for heart failure, diabetes was associated with altered collagen biomarkers and diastolic function; spironolactone had modest short-term effects on collagen turnover markers but no major differential long-term effects by diabetes/CAD status.
In this double-blind, placebo-controlled cross-over trial subgroup, radon spa treatment reduced osteoclast activity and RANKL and increased regulatory T cells versus baseline, suggesting reduced bone resorption; some systemic collagen fragment (CTX) measures were unchanged.
In this double-blind, placebo-controlled cross-over trial subgroup, radon spa treatment reduced osteoclast activity and RANKL and increased regulatory T cells versus baseline, suggesting reduced bone resorption; some systemic collagen fragment (CTX) measures were unchanged.
In this double-blind, placebo-controlled cross-over trial subgroup, radon spa treatment reduced osteoclast activity and RANKL and increased regulatory T cells versus baseline, suggesting reduced bone resorption; some systemic collagen fragment (CTX) measures were unchanged.
Acellular bladder (collagen-based) matrix grafts worked well in patients with a healthy urethral bed but performed worse than buccal mucosa in patients with an unhealthy bed; both groups showed improved urine flow.
Acellular bladder (collagen-based) matrix grafts worked well in patients with a healthy urethral bed but performed worse than buccal mucosa in patients with an unhealthy bed; both groups showed improved urine flow.
Acellular bladder (collagen-based) matrix grafts worked well in patients with a healthy urethral bed but performed worse than buccal mucosa in patients with an unhealthy bed; both groups showed improved urine flow.
A collagen-coated patch (TachoComb) was safe and, in patients with mild–moderate intra-operative leaks, reduced leak intensity and shortened postoperative leak duration compared with standard treatment.
A collagen-coated patch (TachoComb) was safe and, in patients with mild–moderate intra-operative leaks, reduced leak intensity and shortened postoperative leak duration compared with standard treatment.
A collagen-coated patch (TachoComb) was safe and, in patients with mild–moderate intra-operative leaks, reduced leak intensity and shortened postoperative leak duration compared with standard treatment.
A collagen-coated patch (TachoComb) was safe and, in patients with mild–moderate intra-operative leaks, reduced leak intensity and shortened postoperative leak duration compared with standard treatment.
Phase III randomized, double‑blind trial of a bovine type I collagen matrix implant (INL‑001) delivering bupivacaine versus placebo collagen matrix in abdominoplasty patients assessing postoperative pain and opioid use.
Phase III randomized, double‑blind trial of a bovine type I collagen matrix implant (INL‑001) delivering bupivacaine versus placebo collagen matrix in abdominoplasty patients assessing postoperative pain and opioid use.
Phase III randomized, double‑blind trial of a bovine type I collagen matrix implant (INL‑001) delivering bupivacaine versus placebo collagen matrix in abdominoplasty patients assessing postoperative pain and opioid use.
Using a collagenated bovine bone and resorbable collagen membrane after upper back tooth extraction preserved vertical bone height better than no grafting over 6 months.
Using a collagenated bovine bone and resorbable collagen membrane after upper back tooth extraction preserved vertical bone height better than no grafting over 6 months.
Using a collagenated bovine bone and resorbable collagen membrane after upper back tooth extraction preserved vertical bone height better than no grafting over 6 months.
A collagen-containing fibrinogen/thrombin sponge applied to gastrointestinal sutures reduced anastomotic leaks in high-risk oncology patients.
Using a collagenated bovine bone mineral and a resorbable collagen membrane for ridge preservation reduced post-extraction ridge shrinkage and volumetric loss compared with spontaneous healing.
Using a collagenated bovine bone mineral and a resorbable collagen membrane for ridge preservation reduced post-extraction ridge shrinkage and volumetric loss compared with spontaneous healing.
Terutroban improved endothelial function and blocked TP receptor–mediated platelet aggregation in high-cardiovascular-risk patients on aspirin.
Terutroban improved endothelial function and blocked TP receptor–mediated platelet aggregation in high-cardiovascular-risk patients on aspirin.
Progressive high-impact exercise increased bone mass and improved balance and muscle function but did not change MRI-estimated cartilage biochemical composition in postmenopausal women.
Progressive high-impact exercise increased bone mass and improved balance and muscle function but did not change MRI-estimated cartilage biochemical composition in postmenopausal women.
Progressive high-impact exercise increased bone mass and improved balance and muscle function but did not change MRI-estimated cartilage biochemical composition in postmenopausal women.
Alendronate reduced pain and improved pain-related quality of life and increased lumbar BMD more than alfacalcidol in postmenopausal osteoporotic women.
Alendronate prevented glucocorticoid-induced bone loss, increasing BMD at spine and hip sites over 24 weeks compared with calcium alone.
Daily high-calcium mineral water (596 mg Ca) for 6 months lowered PTH and multiple bone turnover markers; adding 400 IU vitamin D provided no additional reduction.
Compared replacement formulas; the formula containing hydrolysed soya plus bovine collagen had fewer sensitivity reactions and similar time to tolerance.
Compared replacement formulas; the formula containing hydrolysed soya plus bovine collagen had fewer sensitivity reactions and similar time to tolerance.
Glyaderm (acellular dermis composed of collagen) showed good graft take and improved scar elasticity/quality versus STSG alone.
Glyaderm (acellular dermis composed of collagen) showed good graft take and improved scar elasticity/quality versus STSG alone.
Biomarker sub-study of an RCT in RA showing tocilizumab reduces collagen-degradation biomarkers and CRP more than methotrexate by week 8.
Monthly oral ibandronate increased lumbar spine and hip BMD and reduced bone turnover markers in postmenopausal women on glucocorticoids; vitamin D and calcium were provided to all.
Monthly oral ibandronate increased lumbar spine and hip BMD and reduced bone turnover markers in postmenopausal women on glucocorticoids; vitamin D and calcium were provided to all.
Experimental challenge study in asthma showing repeated bronchoconstriction (with allergen or methacholine) increases subepithelial collagen deposition and mucus changes independent of eosinophilic inflammation.
Experimental challenge study in asthma showing repeated bronchoconstriction (with allergen or methacholine) increases subepithelial collagen deposition and mucus changes independent of eosinophilic inflammation.
Long‑term extension of ibandronate treatment showing sustained increases in lumbar spine and hip BMD and persistent reductions in type I collagen turnover markers over 3 years.
Clinical study of mandibular Class II furcation defects showing bone graft improves vertical defect fill and that adding a bioabsorbable collagen membrane did not further enhance regeneration.
Clinical study of mandibular Class II furcation defects showing bone graft improves vertical defect fill and that adding a bioabsorbable collagen membrane did not further enhance regeneration.
First-in-human randomized placebo-controlled study: bersiporocin lowered the serum collagen synthesis biomarker Pro-C3 and caused mostly mild gastrointestinal adverse events.
First-in-human randomized placebo-controlled study: bersiporocin lowered the serum collagen synthesis biomarker Pro-C3 and caused mostly mild gastrointestinal adverse events.
First-in-human randomized placebo-controlled study: bersiporocin lowered the serum collagen synthesis biomarker Pro-C3 and caused mostly mild gastrointestinal adverse events.
In PAOO patients, collagen barrier membrane (control) increased gingival thickness modestly at 6 months, but CGF membrane produced a larger increase; both groups showed bone parameter changes.
In PAOO patients, collagen barrier membrane (control) increased gingival thickness modestly at 6 months, but CGF membrane produced a larger increase; both groups showed bone parameter changes.
Pivotal randomized FDA IDE trial comparing i-Factor (P‑15 synthetic collagen fragment bone graft) versus local autograft in single-level anterior cervical fusion with 2-year follow-up; similar clinical outcomes and fusion rates, with a higher composite overall success for i-Factor.
Pivotal randomized FDA IDE trial comparing i-Factor (P‑15 synthetic collagen fragment bone graft) versus local autograft in single-level anterior cervical fusion with 2-year follow-up; similar clinical outcomes and fusion rates, with a higher composite overall success for i-Factor.
Floseal, a collagen-derived hemostatic sealant, was more effective, easier to use, better tolerated, and had lower short-term rebleeding rates than nasal packing for anterior epistaxis.
Floseal, a collagen-derived hemostatic sealant, was more effective, easier to use, better tolerated, and had lower short-term rebleeding rates than nasal packing for anterior epistaxis.
Floseal, a collagen-derived hemostatic sealant, was more effective, easier to use, better tolerated, and had lower short-term rebleeding rates than nasal packing for anterior epistaxis.
Randomized trial (78 enrolled, 8 excluded/dropouts = 70 completed) comparing internal socket grafting alone versus with additional buccal augmentation covered by collagen resorbable membranes; no significant differences at 6 months.
Multicenter randomized trial comparing standard skin grafts vs grafts plus cultured autologous epidermal cells seeded in a collagen carrier; assessed healing and scar quality.
Multicenter randomized trial comparing standard skin grafts vs grafts plus cultured autologous epidermal cells seeded in a collagen carrier; assessed healing and scar quality.
Grafting extraction sockets with DBBM-C (deproteinized bovine bone mineral with 10% porcine collagen) preserved buccal crest height and ridge width significantly better than no graft over 1 year.
Grafting extraction sockets with DBBM-C (deproteinized bovine bone mineral with 10% porcine collagen) preserved buccal crest height and ridge width significantly better than no graft over 1 year.
Grafting extraction sockets with DBBM-C (deproteinized bovine bone mineral with 10% porcine collagen) preserved buccal crest height and ridge width significantly better than no graft over 1 year.
Injecting patients' own dermal fibroblasts between tendon and bone during rotator cuff repair reduced retear rate but did not change shoulder function scores at 6–12 months.
Injecting patients' own dermal fibroblasts between tendon and bone during rotator cuff repair reduced retear rate but did not change shoulder function scores at 6–12 months.
Acellular dermal matrix (ADM) produced more collagen fibers but showed greater tissue shrinkage and delayed healing compared with free gingival grafts.
Acellular dermal matrix (ADM) produced more collagen fibers but showed greater tissue shrinkage and delayed healing compared with free gingival grafts.
In randomized patients, collagen-sealed warp-knitted polyester grafts showed greater early dilation than gelatin-sealed Köper-knitted grafts at day 8; dilation did not increase further at 3 and 6 months.
In randomized patients, collagen-sealed warp-knitted polyester grafts showed greater early dilation than gelatin-sealed Köper-knitted grafts at day 8; dilation did not increase further at 3 and 6 months.
In randomized patients, collagen-sealed warp-knitted polyester grafts showed greater early dilation than gelatin-sealed Köper-knitted grafts at day 8; dilation did not increase further at 3 and 6 months.
Multicenter randomized trial comparing collagen conduit versus processed nerve allograft (PNA) for digital nerve repair: similar results for short gaps but collagen conduits were inferior for long-gap repairs.
Multicenter randomized trial comparing collagen conduit versus processed nerve allograft (PNA) for digital nerve repair: similar results for short gaps but collagen conduits were inferior for long-gap repairs.
Multicenter randomized trial comparing collagen conduit versus processed nerve allograft (PNA) for digital nerve repair: similar results for short gaps but collagen conduits were inferior for long-gap repairs.
Randomized double-blind trial in thalassemia patients: weekly alendronate for 12 months increased lumbar (L1–L4) BMD and reduced bone turnover markers versus placebo.
Randomized trial of sandwich bone augmentation with a collagen (bovine pericardium) barrier membrane showed preserved bone volume but delayed outer-layer maturation and less mineralization versus no membrane.
Randomized trial of sandwich bone augmentation with a collagen (bovine pericardium) barrier membrane showed preserved bone volume but delayed outer-layer maturation and less mineralization versus no membrane.
100 diabetic patients with chronic lower extremity ulcers were randomized to bioengineered skin substitute (BSS), dHACM, or standard wound care using collagen‑alginate dressings; dHACM produced the highest and fastest healing.
100 diabetic patients with chronic lower extremity ulcers were randomized to bioengineered skin substitute (BSS), dHACM, or standard wound care using collagen‑alginate dressings; dHACM produced the highest and fastest healing.
30 patients underwent transcrestal sinus floor elevation randomized to DBBM or synthetic hydroxyapatite in a collagen matrix (S‑HA); both maintained lift, but S‑HA produced greater graft height and sinus lift at 6 months.
30 patients underwent transcrestal sinus floor elevation randomized to DBBM or synthetic hydroxyapatite in a collagen matrix (S‑HA); both maintained lift, but S‑HA produced greater graft height and sinus lift at 6 months.
30 patients underwent transcrestal sinus floor elevation randomized to DBBM or synthetic hydroxyapatite in a collagen matrix (S‑HA); both maintained lift, but S‑HA produced greater graft height and sinus lift at 6 months.
Randomized trial in premenopausal women receiving chemotherapy testing intermittent IV clodronate for prevention of rapid bone loss; biochemical bone turnover marker decreased during therapy but no clear prevention of bone loss.
Randomized trial in premenopausal women receiving chemotherapy testing intermittent IV clodronate for prevention of rapid bone loss; biochemical bone turnover marker decreased during therapy but no clear prevention of bone loss.
Large biomarker study in advanced HCC measuring multiple circulating proteins (including collagen IV) and tissue markers to assess prognosis and etiologic differences.
Large biomarker study in advanced HCC measuring multiple circulating proteins (including collagen IV) and tissue markers to assess prognosis and etiologic differences.
Large biomarker study in advanced HCC measuring multiple circulating proteins (including collagen IV) and tissue markers to assess prognosis and etiologic differences.
Pharmacodynamic substudy of vorapaxar versus placebo showing potent inhibition of PAR-1–mediated platelet aggregation in ACS patients.
Pharmacodynamic substudy of vorapaxar versus placebo showing potent inhibition of PAR-1–mediated platelet aggregation in ACS patients.
Pharmacodynamic substudy of vorapaxar versus placebo showing potent inhibition of PAR-1–mediated platelet aggregation in ACS patients.
Randomized placebo-controlled trial of 50 mg DHEA daily for 1 year showing hormonal changes and modest bone benefits in women but not men.
Polylactic acid injections improved facial appearance, patient self-perception, and anxiety/depression scores in HIV-associated facial lipoatrophy.
Polylactic acid injections improved facial appearance, patient self-perception, and anxiety/depression scores in HIV-associated facial lipoatrophy.
Polylactic acid injections improved facial appearance, patient self-perception, and anxiety/depression scores in HIV-associated facial lipoatrophy.
Randomized multicenter trial comparing immediate post-extractive implants vs delayed implants (delayed group received socket preservation with bovine bone and a resorbable collagen barrier); aesthetics similar, more complications with immediate implants.
Randomized multicenter trial (100 subjects) comparing bioactive split‑thickness skin allograft (contains native collagen and living cells) plus SOC versus SOC alone for diabetic foot ulcers: allograft markedly increased 12‑week healing rates and accelerated healing.
Randomized multicenter trial (100 subjects) comparing bioactive split‑thickness skin allograft (contains native collagen and living cells) plus SOC versus SOC alone for diabetic foot ulcers: allograft markedly increased 12‑week healing rates and accelerated healing.
Randomized multicenter trial (100 subjects) comparing bioactive split‑thickness skin allograft (contains native collagen and living cells) plus SOC versus SOC alone for diabetic foot ulcers: allograft markedly increased 12‑week healing rates and accelerated healing.
1-year randomized trial in healthy adults >65 testing twice-daily protein supplements (including a collagen protein arm); collagen supplementation alone did not improve muscle size, strength, function, or body composition versus carbohydrate control.
1-year randomized trial in healthy adults >65 testing twice-daily protein supplements (including a collagen protein arm); collagen supplementation alone did not improve muscle size, strength, function, or body composition versus carbohydrate control.
1-year randomized trial in healthy adults >65 testing twice-daily protein supplements (including a collagen protein arm); collagen supplementation alone did not improve muscle size, strength, function, or body composition versus carbohydrate control.
Large multicenter randomized trial testing a fibrin–collagen sealant sponge (TachoSil) on pancreatic remnant closure; TachoSil did not reduce rate or severity of postoperative pancreatic fistula.
Large multicenter randomized trial testing a fibrin–collagen sealant sponge (TachoSil) on pancreatic remnant closure; TachoSil did not reduce rate or severity of postoperative pancreatic fistula.
Observational cohort relating baseline bone-derived biomarkers (including CTX-1, a collagen type I turnover marker) to subsequent cognitive decline; higher CTX-1 associated with greater cognitive decline over 18 months.
Observational cohort relating baseline bone-derived biomarkers (including CTX-1, a collagen type I turnover marker) to subsequent cognitive decline; higher CTX-1 associated with greater cognitive decline over 18 months.
Observational cohort relating baseline bone-derived biomarkers (including CTX-1, a collagen type I turnover marker) to subsequent cognitive decline; higher CTX-1 associated with greater cognitive decline over 18 months.
Higher serum LOXL2 levels (an enzyme promoting collagen cross-linking) were associated with increased risk of IPF progression and higher mortality in two cohorts.
Higher serum LOXL2 levels (an enzyme promoting collagen cross-linking) were associated with increased risk of IPF progression and higher mortality in two cohorts.
Higher serum LOXL2 levels (an enzyme promoting collagen cross-linking) were associated with increased risk of IPF progression and higher mortality in two cohorts.
A randomized multicenter FDA IDE trial found the i-Factor bone graft (contains a synthetic collagen fragment P-15) noninferior to autograft for single-level ACDF with high fusion rates and similar safety; overall composite success was higher with i-Factor.
A randomized multicenter FDA IDE trial found the i-Factor bone graft (contains a synthetic collagen fragment P-15) noninferior to autograft for single-level ACDF with high fusion rates and similar safety; overall composite success was higher with i-Factor.
Proteomic analysis of urine from TOPCAT participants identified multiple urinary proteins (including collagen-derived peptides) associated with lower or higher risk of death or HF admission.
Proteomic analysis of urine from TOPCAT participants identified multiple urinary proteins (including collagen-derived peptides) associated with lower or higher risk of death or HF admission.
Proteomic analysis of urine from TOPCAT participants identified multiple urinary proteins (including collagen-derived peptides) associated with lower or higher risk of death or HF admission.
In patients undergoing tooth extraction and socket grafting, a PLGA‑coated β‑tricalcium phosphate graft produced less new mineralized tissue at 20 weeks than freeze‑dried bone allograft, though implant placement and short‑term implant outcomes were comparable.
In patients undergoing tooth extraction and socket grafting, a PLGA‑coated β‑tricalcium phosphate graft produced less new mineralized tissue at 20 weeks than freeze‑dried bone allograft, though implant placement and short‑term implant outcomes were comparable.
In patients undergoing tooth extraction and socket grafting, a PLGA‑coated β‑tricalcium phosphate graft produced less new mineralized tissue at 20 weeks than freeze‑dried bone allograft, though implant placement and short‑term implant outcomes were comparable.
Higher GCF inflammation and collagen-breakdown biomarkers predicted later periodontal attachment and bone loss; subantimicrobial-dose doxycycline modified risk.
Higher GCF inflammation and collagen-breakdown biomarkers predicted later periodontal attachment and bone loss; subantimicrobial-dose doxycycline modified risk.
Higher GCF inflammation and collagen-breakdown biomarkers predicted later periodontal attachment and bone loss; subantimicrobial-dose doxycycline modified risk.
Application of a fibrinogen/thrombin-coated collagen patch did not significantly reduce clinically relevant pancreatic fistulas or hospital stay.
Application of a fibrinogen/thrombin-coated collagen patch did not significantly reduce clinically relevant pancreatic fistulas or hospital stay.
Aldafermin reduced liver fat and lowered a type III collagen biomarker, with trends toward fibrosis improvement.
Aldafermin reduced liver fat and lowered a type III collagen biomarker, with trends toward fibrosis improvement.
Aldafermin reduced liver fat and lowered a type III collagen biomarker, with trends toward fibrosis improvement.
MIV-711 did not improve pain but significantly reduced bone area progression, reduced cartilage thinning, and lowered collagen biomarker levels.
MIV-711 did not improve pain but significantly reduced bone area progression, reduced cartilage thinning, and lowered collagen biomarker levels.
Patterns of platelet inhibition differed by treatment; ER-DP+ASA caused later reductions in multiple platelet activation markers, while clopidogrel (with ASA) inhibited collagen-induced aggregation earlier.
Patterns of platelet inhibition differed by treatment; ER-DP+ASA caused later reductions in multiple platelet activation markers, while clopidogrel (with ASA) inhibited collagen-induced aggregation earlier.
Spironolactone reduced multiple plasma biomarkers including those of collagen metabolism, suggesting antifibrotic effects.
Spironolactone reduced multiple plasma biomarkers including those of collagen metabolism, suggesting antifibrotic effects.
Spironolactone reduced multiple plasma biomarkers including those of collagen metabolism, suggesting antifibrotic effects.
A collagen-derived hemostatic gel (Floseal) produced faster hemostasis, less blood loss, and quicker return to diet than cautery in children having adenoidectomy.
A collagen-derived hemostatic gel (Floseal) produced faster hemostasis, less blood loss, and quicker return to diet than cautery in children having adenoidectomy.
Absorbable plain gut (collagen-derived) sutures produced similar or slightly better long-term cosmetic outcomes than nylon sutures in children.
Absorbable plain gut (collagen-derived) sutures produced similar or slightly better long-term cosmetic outcomes than nylon sutures in children.
3-month randomized placebo-controlled trial in postmenopausal women: oral salmon calcitonin reduced bone resorption markers markedly acutely and modestly at 3 months; all participants received calcium plus 400 IU vitamin D daily but vitamin D effect was not evaluated.
3-month randomized placebo-controlled trial in postmenopausal women: oral salmon calcitonin reduced bone resorption markers markedly acutely and modestly at 3 months; all participants received calcium plus 400 IU vitamin D daily but vitamin D effect was not evaluated.
3-month randomized placebo-controlled trial in postmenopausal women: oral salmon calcitonin reduced bone resorption markers markedly acutely and modestly at 3 months; all participants received calcium plus 400 IU vitamin D daily but vitamin D effect was not evaluated.
Higher plasma LBP and sTLR4 were associated with worse knee OA progression and increased urinary collagen-breakdown marker over 16–18 months.
Higher plasma LBP and sTLR4 were associated with worse knee OA progression and increased urinary collagen-breakdown marker over 16–18 months.
ART initiation increased bone turnover markers; 25(OH)D levels decreased modestly over time in both arms but this was an observational measurement, not a vitamin D intervention.
ART initiation increased bone turnover markers; 25(OH)D levels decreased modestly over time in both arms but this was an observational measurement, not a vitamin D intervention.
ART initiation increased bone turnover markers; 25(OH)D levels decreased modestly over time in both arms but this was an observational measurement, not a vitamin D intervention.
Phase-II randomized trial where a type-I collagen scaffold (NeoCart) seeded with autologous chondrocytes improved several knee outcomes vs microfracture over two years.
Phase-II randomized trial where a type-I collagen scaffold (NeoCart) seeded with autologous chondrocytes improved several knee outcomes vs microfracture over two years.
Phase-II randomized trial where a type-I collagen scaffold (NeoCart) seeded with autologous chondrocytes improved several knee outcomes vs microfracture over two years.
A porcine collagen-elastin dermal substitute plus STSG slowed early graft take and epithelialization versus STSG alone but showed improved scar elasticity at 12 months.
A porcine collagen-elastin dermal substitute plus STSG slowed early graft take and epithelialization versus STSG alone but showed improved scar elasticity at 12 months.
Minimally invasive periodontal surgery produced clinical attachment gains at 1 year; adding deproteinized bovine bone mineral plus a collagen membrane did not improve 1-year outcomes versus surgery alone.
Two types of absorbable collagen membranes (porcine SIS and bovine pericardium) produced similar buccal horizontal bone gain and similar wound healing after single-tooth GBR in diabetic patients at 6 months.
Two types of absorbable collagen membranes (porcine SIS and bovine pericardium) produced similar buccal horizontal bone gain and similar wound healing after single-tooth GBR in diabetic patients at 6 months.